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PMC11802929
PG1-specific cells were dominated by naïve-like phenotypes and exhibited less clonal expansion relative to the other two groups (Supplementary Fig. 6d).
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PMC11727000
We validated the association of USP44 with BRCA2, one of the proteins identified in our study—uncovering a previously unknown function of USP44 in the Fanconi anemia DNA repair pathway.
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PMC9429973
Patients received induction treatment according local protocols [Vd (n=11), VTd (n10), CBd (n=3), VAd (n=2), TD (n=1), VTd-PACE (n=1)] followed by autologous stem cell transplant (ASCT).
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PMC11075223
and Cimicifuga heracleifolia Kom.,
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PMC11352311
The PI3K/Akt pathway plays a critical role in the development of cancer and the emergence of chemotherapeutic drug resistance, making it a focal point of research in various cancers, including RCC .
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PMC11721064
Protein concentration was determined using the bicinchoninic acid (BCA) protein assay (Beyotime Biotechnology).
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PMC11708541
There are no conflicts to declare.
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PMC11596967
Similarly, in D. deserti, approximately 39% of 173 novel leaderless transcripts are predicted to code for peptides of 4 to 15 residues .
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PMC11322866
Western blots showing p21 and p-RB (Ser780) levels in RPMI-8226 and OCI-MY5 cells after GSK126 treatment (0, 1, and 2 μM). (
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PMC11476004
These researchers observed many different types of instabilities in the tumours of the animals, and the heterogeneity and resulting variation in the cells contribute to unpredictable changes at the biological level.
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PMC11209164
Given the dual role of NF-κB in both coordinating the antiviral response as well as cell survival and death, it is tempting to speculate that a shift in baseline NF-κB induced by TPF could contribute to the enhanced impact of TPF on oncolytic activity (Figure 4B,D).
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PMC10849234
We find that both cell lines secrete primary granules, secretory vesicles, and CD107a-marked secretory organelles.
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PMC7553912
Furthermore, mRNA expressions of TGF-β (Fig. 7b) and Col1a2 (Fig. 7c) were induced by OSM in the RTECs and renal fibroblasts, respectively.
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PMC11782508
Most women who develop breast cancer in a high-income country will survive; the opposite is true for women in most low-income and middle-income countries.
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PMC11704135
At a concentration of 15 mg/mL, compound 10 inhibited the growth of S. haemolyticus, whereas S. epidermidis and MRSA required a concentration of 30 mg/mL for inhibition.
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PMC9398137
This pattern was, however, observed also in S63845-resistant Burkitt lyphoma cell line Raji (Fig. 3B).
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PMC9429973
Summary/Conclusion: Our series is mainly distinguished by a low frequency of the HIV association – hematological malignancy, but also by the diversity of these hemopathies.
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PMC9275501
However, in the acidic extracellular environment of tumor cells, the PEG layer gradually separated from the PPBV micelles and the volume of the PPBV micelles was reduced.
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PMC6627640
In total, 800–1500 genes were differentially expressed at least 2-fold with an FDR < 0.01 between cisplatin resistant cells and respective parental cells (Figure 2A and Supplementary Figure S1).
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PMC11795610
TRPV4 mRNA level in the high Ca group showed no significant change relative to normal control group, but its expression was markedly increased in the myricetin intervention groups (Figure 5(a)).
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PMC11720808
NF-κB luciferase assay was carried out to further identify the transcriptional activity of NF-κB, and the result revealed that the transcriptional activity of NF-κB was inhibited by SCU (Figure 2F).
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PMC11723210
Figure 3(a4–a6,b4–b6) show the phase recovery results of the BPR method for two selected regions of the cells.
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PMC9429973
However, common subclonal alterations and dynamic changes were observed in a considerable proportion of patients.
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PMC11509278
The linoleic acid metabolic pathway was also one of the five metabolic pathways affected in the orthotopic lung tumor model .
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PMC11402217
While this study has systematically investigated the inhibitory mechanism of XD23 on OS, we must acknowledge certain limitations.
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PMC10808409
However, the further increase in the Pluronics resulted in an improvement in the EE%, which could be attributed to the formation of more micelles at the high Pluronics concentrations, with the consequence of increasing in the encapsulation of the drug.
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PMC11700523
We have proposed such clinical pathogenesis as MR-associated hypertension and its organ damage, in which MR is pathologically activated regardless of plasma aldosterone levels .
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PMC11052306
These different behaviors correlate with the weak anti-proliferative efficiency observed with 2-G3 and the better efficiency of 2-G3-Cu48, which possesses a distinctive mode of action .
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PMC10470467
Consequently, the signature is also beneficial for formulating chemotherapy and immunotherapy treatment strategies.
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PMC11552389
Figure 2FOXN3 mediated suppression of melanoma cell proliferation, migration, and invasion. (
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PMC9386809
These amazing properties and diverse structure of ferrocene derivatives present them as potential candidates as anticancer agents against brain cancer cell lines (A-172).
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PMC11128598
The combination of chloroquine with any of the drugs employed displayed potent synergistic effects on apoptosis induction, with particularly pronounced efficacy observed in glioblastoma and head and neck cancer cell lines.
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PMC3931643
4EBP2 is expressed in VAL cells but does not block formation of the cap-binding complex following mTOR inhibition.
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PMC9895440
Intergenic n = 3405 cells of 5 mice and Snx9 KO n = 3612 cells of 6 mice.
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PMC10376064
Next, we added a 160 µL cell suspension containing either 30,000 cells/well (calcein AM and Hoechst 33342) or 45,000 cells/well (daunorubicin, rhodamine 123, and pheophorbide A) in either phenol red-free RPMI-1640 (A2780/ADR and H69AR) or phenol red-free DMEM (MDCK II BCRP) without further supplements.
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PMC9429973
Of the 16 pts who were marrow NGS MRD+ at 10 after 3 cycles of iFCG, 6/16 had an MRD recurrence in blood in follow-up vs. 0/20 who were NGS MRD negative/indeterminate (p = 0.004).
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PMC11092382
Moreover, sophocarpine concentration-dependently reduced the level of HBV DNA in culture media (Chen et al., 2016).
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PMC11519077
Moreover, the variability in MSC characteristics and secretory profiles based on tissue of origin underscores the need for personalized approaches to MSC therapy in IBD.
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PMC6114978
Histone deacetylases are known to bind to methylated DNA via the MBD2/3 and MeCP2 adaptor proteins .
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PMC9065483
In parallel, normalization of STAT2 nuclear translocation in accordance with rescued STAT2 phosphorylation by gefitinib treatment was also observed.
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PMC11673902
An automated microfluidic technique, deformational cytometry (DC), greatly improves this problem by combining inertial focusing, hydrodynamic stretching, and automated image analysis, allowing single-cell deformations to be detected at a rate of approximately 2000 cells/s .
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PMC10745221
The measurements from the parent 143B are shown in orange, and those from the revertant 143B cells are shown in blue.
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PMC11589157
The assembled Y-chromosome spans 16.06 Mb.
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PMC11683240
F and G, PT (50 ng/ml = 0.000476 μM) and different concentrations of α1AT or the respective amount of solvent (H2O) were added directly to A549 cells in FCS-free medium and incubated for 4 h at 37 °C.
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PMC11575040
Melanoma cells appear to immune escape from such treatments because they carry multiple potential gene mutations that are presumably attributable to different microenvironments .
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PMC9918897
The tumor cells were characterized by marked anisokaryosis, and their nuclei were large, rounded or oval, heterochromatic, and contained large, prominent nucleoli.
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PMC11319300
Location of the MYEOV-3′-putative enhancer.
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PMC9479186
The results of the wound-healing assay showed that, in BEL-7404 cells, after 48 h of culture, the migration rate of cells in the Lv-shNDUFC1 infection group decreased by 38% (P < 0.001) compared with Lv-shCtrl group ( Figures 2 A, B ).
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PMC10114490
The values of reduced glutathione (GSH) and S-Adenosyl-L-methionine (SAM) remained higher in diHLC-T, even at high concentrations of azathioprine and diclofenac (Fig. 6E).
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PMC8010066
While in the biofilm condition, the MIC of carbapenems was between 3 and 7 μg/mL. The increase of carbapenems susceptibility was not similar among four strains of P.aeruginosa.
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PMC10849234
Therefore, we hypothesized that differentiation of promyelocytic cells with Nutridoma would increase the resultant NLCs’ ability to undergo degranulation as well.
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PMC10812665
The reaction products were quantified at 570 nm (most amino acids) and at 440 nm (for the intermediate products in the case of cysteine and proline).
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PMC11767725
At the core of its pathogenesis lies the IL-23/IL-17 axis, driven by Th17 cells and their cytokines, which create a pro-inflammatory environment.
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PMC9635307
This suggests that CEACAM1 expression is increased during the maturation of B cells in BM.
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PMC11721277
One of the most effective Tc chelators is 6-hydrazinylnicotinic acid (HYNIC), which, when combined with various vector molecules, can be used for targeted delivery of radionuclides to tumor tissues.
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PMC9105697
Marking for duplicates and calling somatic mutations including single nucleotide variants and short indels were detected using DRAGEN Somatic Pipeline (BaseSpace, Illumina Inc., San Diego, CA, USA).
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PMC9429973
The mean expression of the inhibitory CLR NKG2A was significantly higher in DLBCL than in HC samples (42%±5.1 vs. 27%±2.3; p<0.001).
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PMC9429973
Exploratory QOL endpoints included mean change from baseline in EuroQol 5-dimension 5-level (EQ-5D-5L) scores, 12-Item Short Form Health Survey (SF-12), Patient Global Impression of Change (PGIC) and Patient Global Impression of Fatigue Severity (PGIS).
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PMC7582629
In some clinical situations, cellular markers can be used to refine this analysis, but it often remains subjective and limited by the use of light microscopy.
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PMC8540611
Uptake in this case decreased by >2.5 times after one day incubation, which might have been due to the mechanisms of utilization by the cells.
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PMC11473750
The p-value is calculated using a two-sided t-test between each subgroup.
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PMC9444294
Fifty microliters of the sheared lysate was used to confirm shearing efficiency and quantify DNA concentration.
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PMC9910796
Beads were washed five times with 0.1% Triton in PBS and bound proteins were eluted in 30 μl of 2X Laemmli buffer and boiled at 95°C for 3 min.
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PMC8708099
To show differences between quantitative values, an ordinary two-way ANOVA followed by Dunnett’s or Tukey’s multiple comparison tests were performed.
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PMC11306019
Our findings not only revealed structural features important for the antagonistic effects of polyphenols but also provide valuable insights that could significantly contribute to future research in this area.
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PMC9429973
Chromosome-banding analysis was performed using RHG and GTG banding techniques.
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PMC10823017
The PKC-ζ level was reduced to 44% ( Figure 4 ).
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PMC11774112
The flow cytometry results showed that the uptake rates of DTIC and miRNA 34a were greater in PHRD compared to the control.
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PMC10344560
The highest prevalence of fungal peritonitis had been reported in a tropical country such as India, where the rates were as high as 14.3% of all peritonitis episodes (0.09 episodes per patient year) up to 23.8% of all peritonitis episodes.
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PMC9143157
In this study, in the cisplatin-resistant A2780/cis tumor model, we found that P-THP was strongly effective and exhibited a much better anticancer effect than not only cisplatin, but also paclitaxel (Figure 3D).
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PMC10778532
In contrast, no difference was observed for WT VHL cells following sunitinib treatment versus untreated WT VHL cells.
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PMC11319300
Data is visualised on IGV.
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PMC9429973
Pooled risk ratios (RR) with 95% confidence intervals (CI) were calculated using the Mantel-Haenszel method of the fixed-effect model.
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PMC11640419
This allows the cell to initiate a repair program, even if unsuccessful, ultimately leading to apoptosis.
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PMC11429241
The slight increase in COL1A1, SMAD3, and TWIST1 in the SKOV3 cells grown on the OrmoClear printed scaffolds can be explained given that OrmoClear may hinder cell–cell adhesion and provoke the expression of proteins that are required for cell support.
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PMC9429973
Leukemia progression was followed by weekly blood sampling and bioluminescent imaging after injection of luciferin.
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PMC9429973
H. Erba, P. Montesinos, R. Vrhovac, E. Patkowska, H.-J. Kim, P. Zak, P.-N. Wang, T. Mitov, J. Hanyok, L. Liu, A. Benzohra, A. Lesegretain, J. Cortes, A. Perl, M. Sekeres, H. Dombret, S. Amadori, J. Wang, M. Levis, R. Schlenk Duke Cancer Institute, Durham, NC, United States of America; La Fe University and Polytechnic Hospital, Valencia, Spain; University Hospital Centre Zagreb, Zagreb, Croatia; Institute of Hematology and Blood Transfusion, Warsaw, Poland; The Catholic University of Korea, Seoul St. Mary’s Hospital, Seoul, South Korea; University Hospital Hradec Kralove, Hradec Kralove, Czechia; Chang Gung Medical Foundation, Linkou, Taiwan; Daiichi Sankyo UK Ltd, Uxbridge, United Kingdom; Daiichi Sankyo, Inc, Basking Ridge, NJ; Augusta University Medical Center, Augusta, GA; University of Pennsylvania, Philadelphia, PA; University of Miami Health System, Miami, FL, United States of America; Saint Louis Hospital, University of Paris, Paris, France; Tor Vergata Polyclinic Hospital Rome, Rome, Italy; Institute of Hematology and Blood Diseases Hospital, Tianjin, China; Johns Hopkins University, Baltimore, MD, United States of America; Heidelberg University Hospital and German Cancer Research Center, Heidelberg, Germany Background: Quizartinib (Quiz) is an oral, highly potent, and selective type II FLT3 inhibitor with single-agent activity in relapsed/refractory FLT3–internal tandem duplication positive (FLT3-ITD+) acute myeloid leukemia (AML).
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PMC9436459
In this study, the cleavage of the methoxy groups of the heptamethyl ether precursor of ( ±)-kuwanon Y was not attempted due to its unavailable as well as because of the completed total synthesis of kuwanon Y by Lei group.
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PMC11757230
After incubation, the medium was removed, and CLC, CLK, Ema, CL-1, UL-1, and GL-1 cells were added either to the top of the wells with or without cADSCs, or to the bottom of the Transwell membranes with or without cADSCs, at a density of 5 × 10 cells/well in 0.1 mL RPMI complete medium.
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PMC11727145
Indeed, human skin is composed of multiple layers of keratinocytes attached to the underlying dermis, with the inner layers containing proliferating cells in direct contact with the dermis.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11532793
The edgeR function catchSalmon imports transcript counts and associated Gibbs resamples from Salmon to estimate the transcript-specific RTA-dispersions.
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PMC11723947
f Absolute number of spleen cells 21 days after engraftment.
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PMC11459296
Online supplemental table S1 shows the HLA matching loci between the A673 cell line, B-ALL cells, and CB-MNCs.
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PMC11592008
These findings are essential for identifying an in vitro model suitable for studying inflammasome signaling.
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PMC11612794
Right: Electrostatic potential of Mis12C, except for the basic motif of Dsn1, mapped on the surface representation.
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PMC5600151
DEP docetaxel has shown good progress and promising results, and the success in its clinical trials could encourage more investment to take other dendrimer platforms to next phases.
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PMC7039683
Regional plot showing OFC-risk-associated single nucleotide polymorphism (SNPs) near KRT18 from this study.
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PMC11748335
Additionally, we find that genes upregulated in tumors following the loss of short LOCKs are typically poised promoter genes in normal cells, and their transcription is regulated by the ETS1 transcription factor.
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PMC11365427
Row values were quantified by ImageJ to calculate the relative protein abundance.
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PMC11775197
Furthermore, the expression of PPARβ/δ and COX-2 in CRC may promote angiogenesis and the risk of venous vessel invasion .
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PMC11799620
The lipid peroxidation inhibition varied between 45.9 to 86.2% (Figure 4).
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PMC8345486
This in vitro phenomenon in OVCAR-3 cells has been previously reported by others .
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PMC11635087
Research on photosynthetic therapy has been conducted to treat diseases via the induction of photosynthesis in animal tissues and organs using injected algae or thylakoid membranes.
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PMC11755519
It then evaluated the effects of normoxic and hypoxic exosomes secreted by 5637 cells (grade: G2) on the proliferation, migration, and invasion of UMUC2 bladder cancer cells (grade: CIS).
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PMC11489351
For example, the glycolytic enzymes pyruvate kinase muscle isoform and hexokinase 2 and the cell cycle regulator Wee1 were found to be upregulated at low pHi compared to control pHi in Putney’s mouse fibroblast microarray dataset.
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PMC11676169
197–198) are necessary for these interactions.
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PMC11773391
Our study has demonstrated that one of the mechanisms by which tumour cells develop resistance to drugs is through TMZ promoting the transcription of MGMT, which is achieved by activating the ERK pathway.
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PMC11575040
Melanoma cells were transfected with RNAi oligonucleotides directed against LINC00094 (Invitrogen), and random sequence siRNA oligonucleotides (Invitrogen) were used as a negative control.
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PMC11755467
However, both reports documented a vast majority of unaffected miRNAs upon Enoxacin treatment and out of the differentially expressed ones only 8–14% were induced and some miRNAs (up 3%) were even negatively affected.
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PMC11310713
As an ovarian endocrine cell donor for fabrication of GC/TC-laden microbeads (GTBs), 21-day-old immature female Sprague–Dawley rats were subcutaneously injected with 17β-estradiol (E2; Sigma-Aldrich, St. Louis, MO, USA) dissolved in cottonseed oil (1.5 mg/0.2 ml) for 3 consecutive days.
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