OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC11321678	Bigger and smaller circles indicate TFs and NTR genes, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Bigger", "and", "smaller", "circles", "indicate", "TFs", "and", "NTR", "genes", ",", ...
PMC11758416	Timing: 60–90 min 4.Isolate T cell phenotype of interest according to manufacturer protocol or by FACS.a.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Timing", ":", "60–90", "min", "4.Isolate", ...
PMC9429973	Categorical variables were presented as frequencies with percentages, median and interquartile range (IQR) were used to describe continuous variables.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Categorical", ...
PMC11699465	Then the membrane was washed and incubated with HRP-conjugated secondary antibody (Santa Cruz) at 1:5000 dilution.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Then", "the", "membrane", "was", "wash...
PMC11648299	For the SIR analyses, only tumors included in the Swedish official cancer statistics were analyzed, i.e., in situ carcinomas were excluded.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11502327	Yan et al. (195) prepared polyvinyl alcohol/chitosan nanofibers with complete biocompatibility for DOX delivery.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Yan", "et", "al.", "(", "195", ")", "prepared", ...
PMC9917080	Treatment of astrocytes with SeNPs or SeSo for 24 h led to the suppression of the expression of proapoptotic BAX, BIM, and Cas-3, while the effect on the basic expression of apoptosis genes was more pronounced for SeSo (Figure 6C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10204952	Thus, the downregulation of S1P-S1PR1 signaling by SphK1 inhibitors or S1PR1 antagonists is limited in a very narrow range with low S1P concentration.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11612315	DRG cells were then grown in neurobasal medium supplemented with 10% fetal bovine serum (FBS; Gibco, Waltham, MA), 2% B27 supplement (Invitrogen, Carlsbad, CA), and 1% penicillin/streptomycin for 24 h before the experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	.	[ { "tags": [ "O" ], "tokens": [ "." ] } ]
PMC9429973	In MM patients undergoing SGP, detection of a mutation involving a HCG and with a VAF >30% should prompt referral to genetic counseling for confirmatory testing, as PGV detection can have clear implications for patients and their families.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10818573	The presence of EBV in a single cell line can contaminate other cell lines used in the same laboratory, affecting experimental results.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC11711935	Fibroblasts in vitiligo lesions secrete increased amounts of tenascin C, and its elevated levels in the dermis may promote or exacerbate melanocyte detachment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11470381	Save these ROIs, as cells contained within will be used for tracking and polarity analyses across all time frames in the 2D time-lapse video (Figure 2C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4485648	Data were analyzed with FCS Express version 3.0 (De Novo Software, Ontario, Canada).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "were", "analyzed", "with", "FCS", "...
PMC11637284	It consists of two genetic elements, maxicircles (22 kb, 35 copies each) and minicircles (1 kb, ca.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", ...
PMC11412721	To test this hypothesis, we designed a CRISPR-Cas9 approach to perform the knockout of ACKR4 in Raji cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "To", "test", "this", "hy...
PMC11535726	The connection between the sexual morphs of Kirschsteiniotheliaatra (characterised by cylindrical-clavate, bitunicate, 8-spored or rarely 4-spored asci and ellipsoidal verruculose or smooth ascospores with 1–2 septa, lacking a distinct gelatinous sheath) and the asexual morphs (characterised by macronematous, mononematous and branched conidiophores, monotretic, terminal or intercalary, cylindrical, doliiform conidiogenous cells and acrogenous, solitary, cylindrical, oblong, septate conidia with obtuse ends) were previously established by Hughes (1978).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9895440	n = 8 of n = 3 experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "n", "=", "8", "of", "n", "=", "3", "experiments", "." ] } ]
PMC11700165	In contrast to BTK-SYK and TEL-SYK, which predominantly localized in perinuclear region and cytoplasm respectively, ITK-SYK exhibits a more diverse cellular distribution, being present in the nucleus, cytoplasm and membrane-bound compartments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9611901	The next day, slides were washed with distilled water to remove excess salt, immersed in freshly prepared cold denaturing/electrophoresis buffer (300 mmol/L NaOH, 1 mmol/L EDTA, pH > 13) and incubated in the dark at 4 °C for 40 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11701801	SS18 is included in cBAF and ncBAF.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "SS18", "is", "included", "in", "cBAF", "and", "ncBAF", "." ] } ]
PMC11658074	Scale bars = 50 μm.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bars", "=", "50", "μm", "." ] } ]
PMC11352746	This cytotoxicity may also be due to the higher sensitivity of primary neurons compared to that of other cell types.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "cytotoxicity", "may"...
PMC11604768	Individual barcode responses of each THRB-1 (c) or Mafb (e) promoter in FBS or forskolin treated cells, respectively, relative to controls.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11684821	Curiously, in all but one donor these T cells were found to incorporate a conserved TCR-α chain motif, CAXYGGSQGNLIF (where X represents 3–5 amino acids), because of pairing between 10 different TRAV genes and the TRAJ42 gene segment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9844987	The expression of each tag cluster (CAGE-inferred promoter) in each individual LCL was quantified by aggregating the expression of all CTSSs falling within the defined tag cluster region.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11740207	LT-HSCs are small, comparable in size to small lymphocytes, with a typical diameter of 7–10 µm (Figure 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "LT-HSCs", "a...
PMC11680982	Guide for the Care and Use of Laboratory Animals.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Guide", "for", "the", "Care", "and", "Use", "of", "Laboratory", "Animals", "." ] } ]
PMC11626627	The results demonstrate that TWIST1 can bind to the potential binding site (−896nt∼−884 nt).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "results", "demonstrate", "that", "TWIST1", "can...
PMC9429973	In Year 2, improvements for crossover patients paralleled the olipudase alfa group in the primary analysis and improvements continued for the original olipudase alfa group (Table).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7642379	Even though the gene copy number of the parental HEK293 strain is the same as for 293T and 293-H lineages, the FH mRNA levels of HEK293 was as low as the expression levels of the lineages with only half the number of FH gene copies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "B-CellLine", "O", "O", "O", "O", ...
PMC11788920	All crRNA molecules were tested for off-target sites using the Cas-OFFinder tool .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "crRNA", "molecules", "were", "tested", "for", "off-target", "sites", "usi...
PMC9429973	Dose escalation will proceed using a modified Fibonacci design with 1 patient per cohort, proceeding to a standard 3 + 3 design based on protocol specified criteria.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Methods: We longitudinally profiled the TCR repertoires in 67 children with ALL treated on the frontline Ma-Spore ALL 2010 trial, all of whom receive native L-asparaginase in induction, consolidation, and reinduction.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11591038	Emerging evidence has revealed HIF-1α as a potential therapeutic target for various neurological disorders .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Emerging", "evidence", "has", "revealed", "HIF-1α", "as", "a", "...
PMC10998613	PIE-FCCS measurements were carried out in live cells before adding ligand and after the 20-min incubation time.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PIE-FCCS", "measurements", "were", "carried", "ou...
PMC10958426	The distribution of correlation coefficient between gene expression level and CNV level revealed the existence of two populations of DEGs: DEGs with high CNV-expression correlation and DEGs with no CNV-expression correlation (Fig. 4B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5916734	The noncovalent complex of the factors IXa, VIIIa, and X bound to the phospholipid membrane (tenase) is the key element of the positive feedback loop of the coagulation cascade.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10988555	All manipulations involving air-free syntheses and purifications were carried out under a dinitrogen atmosphere using Schlenk techniques.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "manipulations", "involving", "air-free", "...
PMC11449273	The expression of transfected proteins was validated by immunoblotting of total cell extracts (TCEs) using anti-p53 or -plakoglobin (PG) antibodies (Fig 1A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11670407	a Western blot results and semiquantitative analysis of the band density for U2OS cells transfected with siRNA-OTULIN for 48 h. b-c RT‒qPCR results for 143B cells transfected with OTULIN siRNA or an OTULIN-overexpression plasmid for 48 h. d-g Western blot results and semiquantitative analysis of the band density for 143B or U2OS cells transfected with OTULIN shRNA lentivirus or an OTULIN overexpression plasmid.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "...
PMC9429973	A patient’s best response (per the IMWG myeloma response criteria) following induction therapy prior to ASCT was classified into the following categories: progression of disease, less than PR (partial response), partial response (PR), very good partial response (VGPR), complete response (CR), and stringent complete response (sCR).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10547921	Currently, 20% of the ADCs in development use maytansine derivatives as a payload.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Currently", ",", "20", "%", "of", "the", "ADCs", "in"...
PMC11566417	Methods described previously were used for mass spectrometry and analysis .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", "described", "previously", "were", "used", "for", "mass", "spectrometry", "and", "anal...
PMC9429973	Regarding COVID-19 treatment, 30% received dexamethasone 6 mg/day and 30% received thromboprophylaxis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Regarding", "COVID-19", "treatment", ",", "30", "%", "recei...
PMC8526701	The detection of BRDs was confirmed in almost forty-two different proteins expressed in mammalian cells that are responsible for genetic expression and epigenetic changes through multiple mechanisms .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10587429	To validate the humanized NSG-SGM3 mouse model that we established in evaluating immunotherapy, we compared the efficacy of a potentially effective immunotherapy in treating ES xenograft tumors in humanized and non-humanized NSG-SGM3 mice.	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Eligible patients were those with ≥2 recorded visits in the database between Jan 1, 2011 and Oct 31, 2020, ≥18 years of age at the index date (start of FEDR therapy for patients receiving FEDR and last date of RUX therapy for those not receiving FEDR), with data ≥1 month before and after index, and no record of receiving unclassified clinical study drugs prior to index.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Exclusion criteria were failure to consent, and previous inclusion in the Ri-Schedule study within the past 3 months.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Exclusion", "criteria", "were", "...
PMC11434983	These findings underscore Complexes 2 and 2‘s’ promise as multifaceted anticancer agents, combining effective EGFR inhibition and mitochondrial apoptosis induction, and highlight their potential for radiopharmaceutical applications in overcoming therapeutic limitations in EGFR-overexpressing cancers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC3675084	Immunofluorescence was analyzed on an Olympus IX81 inverted fluorescent microscope.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Immunofluorescence", "was", "analyzed", "on", "an", "Olympus", "IX81", "inverted", "fluorescent", ...
PMC9429973	Underlying conditions causing secondary erythrocytosis was found in 25.5% (128/501).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Underlying", "conditions", "causing", "secondary", "erythrocytosis", "was", "foun...
PMC9872547	The expression of these two viral oncogenes is essential for cervical cancer tumorigenesis (37).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "expression", "of", "these", "two", "viral", ...
PMC11291490	They were stimulated with dusCD40L, DMEM (mock), control, or LPS (5 μg/mL) with 1:8 dilution or 1:16 dilution for 48 h. d–f duPBMCs were inoculated in a 12-well plate, 5×10 cells/well.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10818573	At least six standard concentrations were retained from the measured data, and a standard curve was generated using the cycle threshold (CT) values of plasmids with different concentrations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9964635	The anti-cancer potential of all of the compounds was further investigated by molecular docking studies and the results were in accordance with in-vitro studies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	Methods: The methylation status of the promoter region of CD155 was studied in several MM cell lines from COSMIC database and experimentally validated in four (RPMI-8226, MM.1S, AMO-1 and KMS-12-BM).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10778532	We showed that sunitinib is efficient to slow down healing ability in VHL-C162F cells but also in WT VHL and EV cells regardless of VHL status.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", ...
PMC9065483	dissolved in water and pH adjusted to 10 at 150 μM. For in vivo studies, vanadium sulfate at 50 mg/kg (VOSO4, Sigma-Aldrich, cat.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11574271	Currently, the role of miRNAs in controlling RON expression has not been studied.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Currently", ",", "the", "role", "of", "miRNAs", "in", "controlli...
PMC3675084	2N, cells residing in the G0–G1 phase of cell cycle; 4N, cells in the G2 phase or mitosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "2N", ",", "cells"...
PMC11787651	B, correlation heatmap of all replicates of control, M344, and entinostat.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "B", ",", "correlation", "heatmap", "of", "all", "replicates", "o...
PMC11129910	A total of 50 μg of protein from each sample was loaded onto a 12% SDS polyacrylamide gel and subjected to electrophoresis and western blotting.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC10968586	In addition, HT acted as a PPARγ agonist, promoting its transcriptional activity .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ",", "HT", "acted", "as", "a", "PPARγ", "...
PMC11400680	They were applied only for reference to get the location of cells and nuclei on the assembled BF or PhC images.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "They", "were", "a...
PMC11634027	We also included a C-terminal V5 tag so that the levels and distribution of the encoded Ds proteins could be examined.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "also", "inc...
PMC9429973	The study concluded also some very important findings about the role of treatment and quality of life of SCD patients and the need for other treatment options to improve the outcomes of SCD patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9436459	In addition, compared with traditional ligands such as PPh3 or AsPh3, the use of S-Phos as a bulky and electron-rich ligand in this Suzuki−Miyaura coupling step was proved to be a key condition affecting the yield of the product.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Unfortunately, on December 2020 the patient relapsed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Unfortunately", ",", "on", "December", "2020", "the", "patient", "relapsed", "." ] } ]
PMC10125312	Our findings are in good agreement with the use of low AuNR concentration, laser power, and exposure time to promote apoptosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", ...
PMC11321678	Specifically, the log‐rank test (P < 0.0001) showed six subgroup classifications based on NTR genes of MBs had significant prognosis values (Figure S7E–G, Supporting Information).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9454852	Cell death observed after BOLD-100 treatment occurs in an apoptotic way by the activation of caspase 3/7 as well as caspase 8.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", "deat...
PMC6160470	This greater efficiency suggests that in order to inhibit P-gp effectively, crown ethers require an optimal lipophilicity to enter the cell membrane and an additional conformational plasticity to access P-gp binding sites.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9792775	Changes in tumor volume in each group over time ( ± s). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Changes", "in", "tumor", "volume", "in", "each", "group", "over"...
PMC11271278	Source data are provided as a Source Data file.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Source", "data", "are", "provided", "as", "a", "Source", "Data", "file", "." ] } ]
PMC9429973	Two patients experienced G ≥3 infections that were not related to UCART22.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Two", "patients", "experienced", "G", "≥3", "infections", "that", "were", "not",...
PMC10589262	One-way ANOVA with a post-hoc test was performed to compare multiple means (p < 0.05, p < 0.01, **p < 0.001).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10933092	However, further experiments are required to confirm these findings.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "further", "experiments", "are", "required", "to", "confirm", "these", "findings"...
PMC9429973	The 5-year overall CI of sCNSi was 5.1%, and that in L, I, and H of CNS-IPI was 4.0%, 5.3%, and 11.5%, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11216402	Cells having (1) fewer than 500 detected transcripts, (2) more than 20,000 transcripts, (3) fewer than 500 detected genes, or (4) >10% mitochondrial or hemoglobin genes were filtered out for being low quality.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Thus, it is essential to ensure clearance (or prophylaxis) of the disease including the meningeal compartment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "it", "is", "es...
PMC11742231	Fig. 2Adaptive fusion module structure Adaptive fusion module structure In the last layer, the study combines the representations of the drug and cancer cell line to capture their overall relationship.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "...
PMC9429973	In vivo labeling demonstrated a higher half-life of BT Plt, which accumulate in the circulation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "vivo", "labeling", "demonstrated", "a", "higher"...
PMC10747160	Li Wu and Vineet N. KewalRamani); Raji DC-SIGN+ cells (Homo sapiens, Epstein–Barr Virus (EBV)-positive Burkitt lymphoma line originally obtained from the American Type Culture Collection (ATCC); obtained through the NIH HIV Reagent Program, Division of AIDS, NIAID, NIH: Raji cells, ARP-9945; contributed by Drs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11306331	Box plots show median, hinges represent 25th and 75th percentiles; whiskers represent 1.5x inter-quartile range (IQR).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Box", "plots", "show", ...
PMC10850553	After blocking with 3% donkey serum (#AB_2337258, Jackson ImmunoResearch), slices were incubated with primary antibodies followed by incubation with secondary antibodies conjugated with a fluorescence dye.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11644761	In fact, during interphase, before DNA replication, de novo DNA methylation occurs, whereas after a full cell cycle, maintenance DNA methylation also takes place.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11693599	However, whether CD109 can be used as a secretory biomarker for ovarian CSCs remains unclear.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "whether", "CD109", "can", "be", ...
PMC9780037	The nitration of tyrosine 74 was shown to block the activation of caspase-9, a critical step in the induction of apoptosis .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "nitra...
PMC9429973	All pts received IT chemotherapy, both as a primary-intention treatment in the 3 CNS+ pts, and as prophylaxis in the 2 CNS-negative pts.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973	Aims: To profile GB5121 for selectivity, potency, inactivation kinetics and CNS penetrance in comparison to ibrutinib.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ":", "To", "profile", ...
PMC9429973	The most frequently reported AEs (≥30% across tal + dara cohorts) were CRS (65%; all gr 1/2; median time to onset: 2 days; median duration: 2 days), dysgeusia (57%), thrombocytopenia (35%; gr 3/4: 20%), anemia (39%; gr 3/4: 20%), and dry mouth (44%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6181431	The patients received rapalogs for a median of 9.5 months (range: 5.5–46 months), after which they progressed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "patients", ...
PMC11522251	GenePharma (Shanghai, China) provided the negative control siRNA (NC-siRNA) and the HOXB8-targeting siRNA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "GenePharma", "(", "Shanghai", ",", "Ch...
PMC11682525	Following fixation and blocking steps, cells were incubated overnight at 4 °C with rabbit anti-nestin antibody (1:50; Proteintech, #19483–1-AP) or rabbit anti-SOX10 antibody (1:100; Proteintech, #10422–1-AP).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11758416	Centrifuge the T cells at approximately 450 × g for 5 min at 4°C.d.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Centrifuge", "the", "T", "cells", "at", "approximately...
PMC10565698	Therefore, we hypothesized that TCF12 functions downstream of miR-211-5p.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "we", "hypothesized", "that", "TCF12", "functions", "downstream", ...
PMC11786767	B: RO-3306 treatment for 30 min reduces Ki-67 phosphorylation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "B", ":", "RO-3306", "treatment", "for", "30", "min", "reduces", "Ki-67", "phosphorylation", ...
PMC6948907	After addition of AnnexinV-FITC and propidium iodide (PI, Becton-Dickinson, San Diego, CA), analysis was carried out according to the manufacturer’s protocol (BMS500F1/100CE AnnexinV-FITC, eBiscience, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11321678

Bigger and smaller circles indicate TFs and NTR genes, respectively.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Bigger", "and", "smaller", "circles", "indicate", "TFs", "and", "NTR", "genes", ",", ...

PMC11758416

Timing: 60–90 min 4.Isolate T cell phenotype of interest according to manufacturer protocol or by FACS.a.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Timing", ":", "60–90", "min", "4.Isolate", ...

PMC9429973

Categorical variables were presented as frequencies with percentages, median and interquartile range (IQR) were used to describe continuous variables.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Categorical", ...

PMC11699465

Then the membrane was washed and incubated with HRP-conjugated secondary antibody (Santa Cruz) at 1:5000 dilution.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Then", "the", "membrane", "was", "wash...

PMC11648299

For the SIR analyses, only tumors included in the Swedish official cancer statistics were analyzed, i.e., in situ carcinomas were excluded.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC11502327

Yan et al. (195) prepared polyvinyl alcohol/chitosan nanofibers with complete biocompatibility for DOX delivery.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Yan", "et", "al.", "(", "195", ")", "prepared", ...

PMC9917080

Treatment of astrocytes with SeNPs or SeSo for 24 h led to the suppression of the expression of proapoptotic BAX, BIM, and Cas-3, while the effect on the basic expression of apoptosis genes was more pronounced for SeSo (Figure 6C).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10204952

Thus, the downregulation of S1P-S1PR1 signaling by SphK1 inhibitors or S1PR1 antagonists is limited in a very narrow range with low S1P concentration.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC11612315

DRG cells were then grown in neurobasal medium supplemented with 10% fetal bovine serum (FBS; Gibco, Waltham, MA), 2% B27 supplement (Invitrogen, Carlsbad, CA), and 1% penicillin/streptomycin for 24 h before the experiments.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

.

[ { "tags": [ "O" ], "tokens": [ "." ] } ]

PMC9429973

In MM patients undergoing SGP, detection of a mutation involving a HCG and with a VAF >30% should prompt referral to genetic counseling for confirmatory testing, as PGV detection can have clear implications for patients and their families.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10818573

The presence of EBV in a single cell line can contaminate other cell lines used in the same laboratory, affecting experimental results.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...

PMC11711935

Fibroblasts in vitiligo lesions secrete increased amounts of tenascin C, and its elevated levels in the dermis may promote or exacerbate melanocyte detachment.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC11470381

Save these ROIs, as cells contained within will be used for tracking and polarity analyses across all time frames in the 2D time-lapse video (Figure 2C).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC4485648

Data were analyzed with FCS Express version 3.0 (De Novo Software, Ontario, Canada).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "were", "analyzed", "with", "FCS", "...

PMC11637284

It consists of two genetic elements, maxicircles (22 kb, 35 copies each) and minicircles (1 kb, ca.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", ...

PMC11412721

To test this hypothesis, we designed a CRISPR-Cas9 approach to perform the knockout of ACKR4 in Raji cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "To", "test", "this", "hy...

PMC11535726

The connection between the sexual morphs of Kirschsteiniotheliaatra (characterised by cylindrical-clavate, bitunicate, 8-spored or rarely 4-spored asci and ellipsoidal verruculose or smooth ascospores with 1–2 septa, lacking a distinct gelatinous sheath) and the asexual morphs (characterised by macronematous, mononematous and branched conidiophores, monotretic, terminal or intercalary, cylindrical, doliiform conidiogenous cells and acrogenous, solitary, cylindrical, oblong, septate conidia with obtuse ends) were previously established by Hughes (1978).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9895440

n = 8 of n = 3 experiments.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "n", "=", "8", "of", "n", "=", "3", "experiments", "." ] } ]

PMC11700165

In contrast to BTK-SYK and TEL-SYK, which predominantly localized in perinuclear region and cytoplasm respectively, ITK-SYK exhibits a more diverse cellular distribution, being present in the nucleus, cytoplasm and membrane-bound compartments.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9611901

The next day, slides were washed with distilled water to remove excess salt, immersed in freshly prepared cold denaturing/electrophoresis buffer (300 mmol/L NaOH, 1 mmol/L EDTA, pH > 13) and incubated in the dark at 4 °C for 40 min.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11701801

SS18 is included in cBAF and ncBAF.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "SS18", "is", "included", "in", "cBAF", "and", "ncBAF", "." ] } ]

PMC11658074

Scale bars = 50 μm.

[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bars", "=", "50", "μm", "." ] } ]

PMC11352746

This cytotoxicity may also be due to the higher sensitivity of primary neurons compared to that of other cell types.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "cytotoxicity", "may"...

PMC11604768

Individual barcode responses of each THRB-1 (c) or Mafb (e) promoter in FBS or forskolin treated cells, respectively, relative to controls.

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PMC11684821

Curiously, in all but one donor these T cells were found to incorporate a conserved TCR-α chain motif, CAXYGGSQGNLIF (where X represents 3–5 amino acids), because of pairing between 10 different TRAV genes and the TRAJ42 gene segment.

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PMC9844987

The expression of each tag cluster (CAGE-inferred promoter) in each individual LCL was quantified by aggregating the expression of all CTSSs falling within the defined tag cluster region.

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PMC11740207

LT-HSCs are small, comparable in size to small lymphocytes, with a typical diameter of 7–10 µm (Figure 1).

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PMC11680982

Guide for the Care and Use of Laboratory Animals.

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PMC11626627

The results demonstrate that TWIST1 can bind to the potential binding site (−896nt∼−884 nt).

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PMC9429973

In Year 2, improvements for crossover patients paralleled the olipudase alfa group in the primary analysis and improvements continued for the original olipudase alfa group (Table).

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PMC7642379

Even though the gene copy number of the parental HEK293 strain is the same as for 293T and 293-H lineages, the FH mRNA levels of HEK293 was as low as the expression levels of the lineages with only half the number of FH gene copies.

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PMC11788920

All crRNA molecules were tested for off-target sites using the Cas-OFFinder tool .

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PMC9429973

Dose escalation will proceed using a modified Fibonacci design with 1 patient per cohort, proceeding to a standard 3 + 3 design based on protocol specified criteria.

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PMC9429973

Methods: We longitudinally profiled the TCR repertoires in 67 children with ALL treated on the frontline Ma-Spore ALL 2010 trial, all of whom receive native L-asparaginase in induction, consolidation, and reinduction.

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PMC11591038

Emerging evidence has revealed HIF-1α as a potential therapeutic target for various neurological disorders .

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PMC10998613

PIE-FCCS measurements were carried out in live cells before adding ligand and after the 20-min incubation time.

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PMC10958426

The distribution of correlation coefficient between gene expression level and CNV level revealed the existence of two populations of DEGs: DEGs with high CNV-expression correlation and DEGs with no CNV-expression correlation (Fig. 4B).

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PMC5916734

The noncovalent complex of the factors IXa, VIIIa, and X bound to the phospholipid membrane (tenase) is the key element of the positive feedback loop of the coagulation cascade.

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PMC10988555

All manipulations involving air-free syntheses and purifications were carried out under a dinitrogen atmosphere using Schlenk techniques.

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PMC11449273

The expression of transfected proteins was validated by immunoblotting of total cell extracts (TCEs) using anti-p53 or -plakoglobin (PG) antibodies (Fig 1A).

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PMC11670407

a Western blot results and semiquantitative analysis of the band density for U2OS cells transfected with siRNA-OTULIN for 48 h. b-c RT‒qPCR results for 143B cells transfected with OTULIN siRNA or an OTULIN-overexpression plasmid for 48 h. d-g Western blot results and semiquantitative analysis of the band density for 143B or U2OS cells transfected with OTULIN shRNA lentivirus or an OTULIN overexpression plasmid.

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PMC9429973

A patient’s best response (per the IMWG myeloma response criteria) following induction therapy prior to ASCT was classified into the following categories: progression of disease, less than PR (partial response), partial response (PR), very good partial response (VGPR), complete response (CR), and stringent complete response (sCR).

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PMC10547921

Currently, 20% of the ADCs in development use maytansine derivatives as a payload.

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PMC11566417

Methods described previously were used for mass spectrometry and analysis .

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PMC9429973

Regarding COVID-19 treatment, 30% received dexamethasone 6 mg/day and 30% received thromboprophylaxis.

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PMC8526701

The detection of BRDs was confirmed in almost forty-two different proteins expressed in mammalian cells that are responsible for genetic expression and epigenetic changes through multiple mechanisms .

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PMC10587429

To validate the humanized NSG-SGM3 mouse model that we established in evaluating immunotherapy, we compared the efficacy of a potentially effective immunotherapy in treating ES xenograft tumors in humanized and non-humanized NSG-SGM3 mice.

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PMC9429973

Eligible patients were those with ≥2 recorded visits in the database between Jan 1, 2011 and Oct 31, 2020, ≥18 years of age at the index date (start of FEDR therapy for patients receiving FEDR and last date of RUX therapy for those not receiving FEDR), with data ≥1 month before and after index, and no record of receiving unclassified clinical study drugs prior to index.

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PMC9429973

Exclusion criteria were failure to consent, and previous inclusion in the Ri-Schedule study within the past 3 months.

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PMC11434983

These findings underscore Complexes 2 and 2‘s’ promise as multifaceted anticancer agents, combining effective EGFR inhibition and mitochondrial apoptosis induction, and highlight their potential for radiopharmaceutical applications in overcoming therapeutic limitations in EGFR-overexpressing cancers.

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PMC3675084

Immunofluorescence was analyzed on an Olympus IX81 inverted fluorescent microscope.

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PMC9429973

Underlying conditions causing secondary erythrocytosis was found in 25.5% (128/501).

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PMC9872547

The expression of these two viral oncogenes is essential for cervical cancer tumorigenesis (37).

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PMC11291490

They were stimulated with dusCD40L, DMEM (mock), control, or LPS (5 μg/mL) with 1:8 dilution or 1:16 dilution for 48 h. d–f duPBMCs were inoculated in a 12-well plate, 5×10 cells/well.

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PMC10818573

At least six standard concentrations were retained from the measured data, and a standard curve was generated using the cycle threshold (CT) values of plasmids with different concentrations.

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PMC9964635

The anti-cancer potential of all of the compounds was further investigated by molecular docking studies and the results were in accordance with in-vitro studies.

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PMC9429973

Methods: The methylation status of the promoter region of CD155 was studied in several MM cell lines from COSMIC database and experimentally validated in four (RPMI-8226, MM.1S, AMO-1 and KMS-12-BM).

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PMC10778532

We showed that sunitinib is efficient to slow down healing ability in VHL-C162F cells but also in WT VHL and EV cells regardless of VHL status.

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PMC9065483

dissolved in water and pH adjusted to 10 at 150 μM. For in vivo studies, vanadium sulfate at 50 mg/kg (VOSO4, Sigma-Aldrich, cat.

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PMC11574271

Currently, the role of miRNAs in controlling RON expression has not been studied.

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PMC3675084

2N, cells residing in the G0–G1 phase of cell cycle; 4N, cells in the G2 phase or mitosis.

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PMC11787651

B, correlation heatmap of all replicates of control, M344, and entinostat.

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PMC11129910

A total of 50 μg of protein from each sample was loaded onto a 12% SDS polyacrylamide gel and subjected to electrophoresis and western blotting.

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PMC10968586

In addition, HT acted as a PPARγ agonist, promoting its transcriptional activity .

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PMC11400680

They were applied only for reference to get the location of cells and nuclei on the assembled BF or PhC images.

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PMC11634027

We also included a C-terminal V5 tag so that the levels and distribution of the encoded Ds proteins could be examined.

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PMC9429973

The study concluded also some very important findings about the role of treatment and quality of life of SCD patients and the need for other treatment options to improve the outcomes of SCD patients.

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PMC9436459

In addition, compared with traditional ligands such as PPh3 or AsPh3, the use of S-Phos as a bulky and electron-rich ligand in this Suzuki−Miyaura coupling step was proved to be a key condition affecting the yield of the product.

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PMC9429973

Unfortunately, on December 2020 the patient relapsed.

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PMC10125312

Our findings are in good agreement with the use of low AuNR concentration, laser power, and exposure time to promote apoptosis.

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PMC11321678

Specifically, the log‐rank test (P < 0.0001) showed six subgroup classifications based on NTR genes of MBs had significant prognosis values (Figure S7E–G, Supporting Information).

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PMC9454852

Cell death observed after BOLD-100 treatment occurs in an apoptotic way by the activation of caspase 3/7 as well as caspase 8.

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PMC6160470

This greater efficiency suggests that in order to inhibit P-gp effectively, crown ethers require an optimal lipophilicity to enter the cell membrane and an additional conformational plasticity to access P-gp binding sites.

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PMC9792775

Changes in tumor volume in each group over time ( ± s). (

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PMC11271278

Source data are provided as a Source Data file.

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PMC9429973

Two patients experienced G ≥3 infections that were not related to UCART22.

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PMC10589262

One-way ANOVA with a post-hoc test was performed to compare multiple means (*p < 0.05, **p < 0.01, ***p < 0.001).

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PMC10933092

However, further experiments are required to confirm these findings.

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PMC9429973

The 5-year overall CI of sCNSi was 5.1%, and that in L, I, and H of CNS-IPI was 4.0%, 5.3%, and 11.5%, respectively.

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PMC11216402

Cells having (1) fewer than 500 detected transcripts, (2) more than 20,000 transcripts, (3) fewer than 500 detected genes, or (4) >10% mitochondrial or hemoglobin genes were filtered out for being low quality.

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PMC9429973

Thus, it is essential to ensure clearance (or prophylaxis) of the disease including the meningeal compartment.

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PMC11742231

Fig. 2Adaptive fusion module structure Adaptive fusion module structure In the last layer, the study combines the representations of the drug and cancer cell line to capture their overall relationship.

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PMC9429973

In vivo labeling demonstrated a higher half-life of BT Plt, which accumulate in the circulation.

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PMC10747160

Li Wu and Vineet N. KewalRamani); Raji DC-SIGN+ cells (Homo sapiens, Epstein–Barr Virus (EBV)-positive Burkitt lymphoma line originally obtained from the American Type Culture Collection (ATCC); obtained through the NIH HIV Reagent Program, Division of AIDS, NIAID, NIH: Raji cells, ARP-9945; contributed by Drs.

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PMC11306331

Box plots show median, hinges represent 25th and 75th percentiles; whiskers represent 1.5x inter-quartile range (IQR).

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PMC10850553

After blocking with 3% donkey serum (#AB_2337258, Jackson ImmunoResearch), slices were incubated with primary antibodies followed by incubation with secondary antibodies conjugated with a fluorescence dye.

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PMC11644761

In fact, during interphase, before DNA replication, de novo DNA methylation occurs, whereas after a full cell cycle, maintenance DNA methylation also takes place.

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PMC11693599

However, whether CD109 can be used as a secretory biomarker for ovarian CSCs remains unclear.

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PMC9780037

The nitration of tyrosine 74 was shown to block the activation of caspase-9, a critical step in the induction of apoptosis .

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PMC9429973

All pts received IT chemotherapy, both as a primary-intention treatment in the 3 CNS+ pts, and as prophylaxis in the 2 CNS-negative pts.

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PMC9429973

Aims: To profile GB5121 for selectivity, potency, inactivation kinetics and CNS penetrance in comparison to ibrutinib.

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PMC9429973

The most frequently reported AEs (≥30% across tal + dara cohorts) were CRS (65%; all gr 1/2; median time to onset: 2 days; median duration: 2 days), dysgeusia (57%), thrombocytopenia (35%; gr 3/4: 20%), anemia (39%; gr 3/4: 20%), and dry mouth (44%).

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PMC6181431

The patients received rapalogs for a median of 9.5 months (range: 5.5–46 months), after which they progressed.

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PMC11522251

GenePharma (Shanghai, China) provided the negative control siRNA (NC-siRNA) and the HOXB8-targeting siRNA.

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PMC11682525

Following fixation and blocking steps, cells were incubated overnight at 4 °C with rabbit anti-nestin antibody (1:50; Proteintech, #19483–1-AP) or rabbit anti-SOX10 antibody (1:100; Proteintech, #10422–1-AP).

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PMC11758416

Centrifuge the T cells at approximately 450 × g for 5 min at 4°C.d.

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PMC10565698

Therefore, we hypothesized that TCF12 functions downstream of miR-211-5p.

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PMC11786767

B: RO-3306 treatment for 30 min reduces Ki-67 phosphorylation.

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PMC6948907

After addition of AnnexinV-FITC and propidium iodide (PI, Becton-Dickinson, San Diego, CA), analysis was carried out according to the manufacturer’s protocol (BMS500F1/100CE AnnexinV-FITC, eBiscience, USA).

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