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OTAR3088
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BioData-CellLine_annotated

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PMC9917080
Cell cultures were used from the third passage.
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PMC10079526
Some epigenetic alterations are involved in oncogenic transformation of cells and the reversibility of epigenetic modifications makes them an interesting target for therapy.
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PMC2614416
Pump D is used for sample loading on captrap cartridge (sample concentration and de-salting) at 50 μL/minute for 5 minutes. •
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PMC9429973
The majority of evaluable patients (n=13/15) indicated an improved disease state compared to baseline on the PGIC at Week 135.
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PMC10523483
G and H) GCLC and H1C levels in A549 cells at 24 h after transfection of indicated plasmids. (
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PMC11087301
Low expression of the miR-200 family have also been defined in normal animal and human stem cells and malignant CSCs, amplifying the molecular correlations between normal stem cells, CSCs along with the functions of the miR-200 family in modulating EMT and stemness .
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PMC11792766
The combination of methanol and acetone is compatible for preparing samples via the extraction of food simulant E. The solvents did not show background cytotoxicity responses at a 0.5% v/v combined concentration and can create a homogeneous exposure sample.
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PMC11653533
non-adventitious roots; marginally roughened, cylindrical and greyish or pale dark colored bark; pubescent branchlets, simple palmate, blade obovate, ovate, and thick leaves which are profoundly separated into 3 to 7 primary projections and harsh on the upper surface but delicate and bushy on the underside (Starr et al., 2003, McGovern, 2002, Rashid et al., 2017).
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PMC11679033
To measure the extent of DNA instability in single cells, slides were stained with ethidium bromide (20 µg/mL).
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PMC11756514
The binding of MBL and langerin ECD to S. aureus JE2 WT and its WTA mutants in the presence of either calcium or EDTA was analyzed by flow cytometry.
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PMC5673955
Perhaps, 9 h is a sufficient period for the down‐regulation of hTERT expression to the minimal level and is necessary for RrA to penetrate through cell and nuclei membranes and activation of suppressors of hTERT gene expression or binding regulate elements in promotor region of hTERT gene.
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PMC10818573
EBV, also known as human herpesvirus type IV, belongs to the γ subfamily, genus Lymphocryptovirus .
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PMC11701801
To measure cell viability after siRNA transfection, cells were trypsinized, counted, and reseeded in 24-well plates at a density of 1 to 2 × 10 cells per well.
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PMC11696659
There were no set thresholds pre-defined for evaluation of the models and, by default, it was 0.5.
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PMC4443654
While cell-type-specific prediction accuracy remained high for each method, cross-application between cell types confirmed our random forest approach as that most capable of learning generalizable rules of compartment prediction (Additional file 1: Figure S7).
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PMC5415764
Therefore, drug resistance represents a major obstacle to improving the overall response and survival of cancer patients.
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PMC9429973
Aims: The present study aimed to elucidate the underlying mechanism of ZnO NPs induced apoptosis in acute myeloid leukemia (AML) cells by regulating mitochondrial division.
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PMC11478724
Mitochondria play a vital role in regulating cell growth and death, energy production, and the ROS production.
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PMC11429241
The insights gained from this study highlight the potential of TPP-fabricated scaffolds in cancer research.
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PMC10887351
Our studies have showed the main roles of β3-ARs in different tumors, in particular pediatric ones .
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PMC9918897
Our results indicate the possible negative countereffect of ethanol; however, further investigations are needed.
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PMC11306019
On day 8, the medium was refreshed with 10 mL of the drug-containing medium.
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PMC11568601
For multiple group comparisons, one-way analysis of variance (ANOVA) was performed to test for statistically significant differences, followed by the Bonferroni correction.
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PMC10965680
Furthermore, we included the whole-genome data of 139 goats from six different populations across China for subsequent analysis.
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PMC10988555
Recrystallized from dichloromethane/n-hexane; orange crystals; yield: 56%.
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PMC11766174
To demonstrate the applicability to clinical samples, CA-ICC was used to quantify the activity of TACK to induce cell death of either in vitro infected PBMCs or ex vivo treated PBMCs from PLWHs on cART (Figure 4 and Figure 5).
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PMC11727062
This property suggests that baicalein could serve as a potential targeted therapeutic agent and an adjuvant for tumor cell vaccines in antimelanoma strategies (Liu et al. 2018).
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PMC9429973
In the P/M arm, iron, TSAT, and LIC decreased 24 wks after starting mitapivat (Wk 48 post BL).
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PMC8389560
The nanoparticle size was characterized using a DC24000 analytical centrifuge (CPS Instruments, Prairieville, LA, USA).
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PMC11594588
The occurrence of an acute thrombotic event in patients with cancer is associated with significant morbidity and mortality.
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PMC10222971
One of the earlier events of apoptosis includes the translocation of membrane phosphatidylserine (PS) from the inner side of the plasma membrane to the surface, leading to the loss of plasma membrane asymmetry.
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PMC9813422
EBV genome tethering can be achieved not only through direct recognition of the specific DNA sequences of these two domains but also through association with chromosome-binding proteins such as chromosome-associated EBP2, BRD4, RCC1, HMGB2, and PARP1 (24-28).
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PMC11471157
As shown in Fig. 4, no significant difference was observed in the expression levels of total ERK1/2 between HaCaT cells cultured with DFP (DFP-HaCaT group) and those cultured in standard plastic dishes (PD-HaCaT group).
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PMC8348645
The supernatant was discarded and the RNA pellet was washed by adding 1 mL of 70% ethanol.
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PMC9318744
The cell-free virus supernatant was harvested, stored, and titered as described for the WT virus.
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PMC11766174
Murine blood was collected by retro-orbital bleeding before and after injection of HIV-infected PBMCs.
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PMC11730320
The final set of unique sequences represented by at least 2 reads was filtered and serves as input to the V(D)J reference aligner.
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PMC9429973
Translocation t(11;14) - in 16/18 (88,9%) cases.
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PMC11629461
The human thyroid follicular epithelial cell line SW579 (#1101HUM‐PUMC000264) was from Cell Resource Center, Peking Union Medical College (http://cellresource.cn, Beijing, China).
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PMC11742290
This study also showed that LGR5-KD increased cell motility in an LGR5-transfected clone with LGR5 overexpression .
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PMC11361748
Final data were gated and analyzed using FlowJo.
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PMC11092382
Furthermore, the reported pharmacological studies regarding organ protection by sophocarpine have focused mainly on cardiovascular diseases.
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PMC11541409
40(16_suppl): p. 11513-11513.This reference is of importance because it reports that olverembatinib is a promising drug for SDH-deficient GIST patients.
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PMC11093197
All cells were maintained in a humidified CO2 incubator at 37°C.
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PMC11754784
e Flow cytometry analysis of different cancer cells in clinical human blood samples using DNPs.
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PMC11361748
Individual symbols depict data using neutrophils from different donors (n = 4).
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PMC9429973
The effect of P53 mutation on outcome parameters was estimated with a 95% confidence interval odds ratio.
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PMC11628309
Additionally, the use of various drugs and toxins to replicate neurodegeneration mechanisms in this type of model is essential, as it is important to understand both the mechanisms of action of these toxins and whether the model being used expresses the receptors or molecular machinery necessary for these toxins to induce cellular damage.
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PMC11286266
ATF6α/IRE1 dual reporter cells were transduced with a CHO sgRNA CRISPR knockout (KO) library.
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PMC9429973
Methods: This retrospective analysis identified adult patients diagnosed with RR-DLBCL [01/01/2014 – 03/31/2021] who received CAR-T therapy and experienced a subsequent disease progression or death.
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PMC10329074
P < 0.01, ***P < 0.001.
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PMC11802855
Additionally, a significant co-localization of the expression of CXCL7 and JAK/STAT3 was discerned).
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PMC11739484
These findings align with previous studies that have highlighted the prognostic significance of MMPs in various cancers.
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PMC10317042
Taken together, our findings suggest that SOX10 plays a crucial role in CCS biology.
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PMC11753949
COS-7 cells were fixed in 4% PFA in PBS.
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PMC8193046
Compounds 21 and 25 were shown to be selective ABCB1 and ABCG2 inhibitors, respectively, while compound 20 did inhibit neither of the evaluated transporters.
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PMC10538569
Furthermore, GPI-scFv X5 CEMss cells when cocultured with primary CD4 T cells were not found to pass GPI-scFv X5 from transduced CEMss cells to untransduced primary CD4 T cells ( Figures S4A–C ).
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PMC11381192
Relationships between CSI and clinical characteristics in MM. (
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PMC11670954
Then, BA and LPS were added to the Caco2 cells according to the experimental protocol.
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PMC10940855
Multiple myeloma cells also express EPHB receptors (Supplementary Fig. S3D and S3E), which could interact with EFNB2 and stimulate its reverse signaling capacity.
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PMC11597291
The non-covalent modifications include hydrophobic, electrostatic, hydrogen-bonding, and π–π stacking interactions .
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PMC11462673
E RT-PCR analysis showed that knockout of the identified enhancer sequence resulted in diminished c-Myb RNA expression levels, while there was no statistically significant difference in the expression levels of the AHI1 gene MYB serves as a crucial downstream molecule of LDB1 complex.
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PMC10944868
If predicted non-substrate of the P-glycoprotein (PGP-), the related point is in red.
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PMC11741906
These targets may play crucial roles and affect the cell cycle, apoptosis, cell proliferation, and p53 signaling pathway.
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PMC11401358
A 10-μL aliquot of diluted sample was dropped on a freshly cleaved mica surface (ϕ = 10 mm, Ted Pella, Redding, CA, USA) and dried before imaging.
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PMC11277157
Genomic loci were annotated using GENCODE (release 46).
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PMC11650848
It may also arise through alterations in DNA methylation as a result of the mQTLs within the ZFP57 alternative promoter.
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PMC11093197
After overnight infection, cells were subjected to selection with 1 μg/ml puromycin (#ant‐pr‐1, Invivogen) for 72 h. For H‐RAS induction, cells were subjected to selection with 200 μg/mL hygromycin for 72 h. A total of 1.5 × 10 cells were seeded onto six‐well plates and cultured overnight.
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PMC6133382
With this gene knocked out, complex, sialic acid–containing glycans cannot be formed, and N-linked glycosylation is not processed beyond the oligomannose Man5 structure (Fig 1).
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PMC9429973
In order to determine the changes in expression pattern of NHEJ genes during the course of T-ALL, gene expression was assessed at different time points, including clinical sample at diagnosis, minimal residual diseaseand at relapse.
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PMC10812665
Car is best known for inhibition of acetylcholine esterase, but it may also have other intracellular targets.
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PMC11774747
The manufacturing process is complex and time-consuming, often taking weeks to harvest, engineer, and expand the patient’s own T cells (1).
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PMC11643491
Unmodified spherical 0.8 μm polystyrene particles fluorescing at an excitation/emission of 590/620 nm were used in this assay, together with the particles that had undergone stretching.
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PMC3915447
This result supports the promotion of FA-induced apoptosis by SPIO, which was related to the level of genes and proteins expression.
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PMC11509224
Seven spongian diterpenes, ceylonamides A–F (153–158, Figure 14) and 15α,16-dimethoxyspongi-13-en-19-oic acid (159), were isolated from the Indonesian marine sponge Spongia ceylonensis .
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PMC11461874
Mice (C57BL/6 background) were handled in accordance with the Guidelines for the Care and Use of Laboratory Animals at The University of Tokyo.
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PMC8358006
c Functional enrichment for genes along the H3K27me3 breadth continuum.
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PMC10723784
The cell line is sensitive to cancer chemotherapeutic drugs such as cisplatin and carboplatin that are used in the clinic.
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PMC9503541
Similarly, the ethyl acetate extract showed in vivo chemopreventive effects against azoxymethane-induced colonic aberrant crypt foci (ACF) by significantly lowering the ACF formation in rats .
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PMC11283030
The results demonstrated that both p-mTOR and p-AKT expression levels were rescued when sodium acetate (5 mM) was administered in these ACLY knockdown cells (P = 0.005, P = 0.011 for 786-O, P = 0.030, P = 0.016 for A498, Fig. S7), which indicated ACLY regulate the AKT/mTORC1 pathway through acetyl-CoA, the product of ACLY, in these ACLY knockdown cells.
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PMC11297139
However, PrLD1 Corelet condensates failed to recruit SMARCB1 and SMARCD1.
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PMC11409031
In summary, in-depth research on the mechanism of cell apoptosis in OV can help understand the occurrence and development of tumors.
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PMC7154001
Three hundred and twenty-one out of 830 articles were duplicated or review articles and were initially excluded from the analysis.
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PMC11725127
P < 0.05, P < 0.01, P < 0.001, P < 0.0001 versus control group.
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PMC11437637
Differences between the sample and population means are represented by t or Z, and sample characteristics are expressed as`x±s or M (P25, P75).
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PMC9583612
Figure 4 shows the time series of the same-day measurements of tank emissions as recorded by Bridger and SeekOps across basins A and B. Most measurements occurred within a span of 8 hours at each site and varied by over an order of magnitude within a given day.
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PMC11401350
Subsequently the transduced T cells were co-cultured with BMDM in a ratio 1:1 for 72 h and then analyzed by FACS using staining with anti-CD3 APCcy7 (130–102-306) and F4/80 PE (130–116-499) from Miltenyi Biotec (Paris, France) and staining for death cells with DAPI.
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PMC11011020
Ph.D. Thesis, University of Cambridge, Cambridge, UK, 2019.
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PMC9024365
However, SD1 does not affect the biophysical properties of AMPARs, such as deactivation and desensitization to glutamate (Lovero et al., 2013), indicating SD1 is not a typical auxiliary factor.
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PMC11773391
Overexpression of MGMT attenuates ERK inhibitor‐induced TMZ sensitization. (
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PMC6379402
On our dataset, NG-WSSNMTF’s iterative solver starts diverging after few (≈100) iterations.
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PMC9429973
A total of 111 patients had progression or relapse, 63 after MBVP and 48 after R-MBVP.
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PMC11047729
Retinoic acids are essential in myeloid differentiation.
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PMC11731161
Tet-on shUSP7-U266 myeloma cells (2 × 10) in 100µL of PBS were injected subcutaneously.
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PMC11754436
BC and NC represent Blank Control and Negative Control respectively.
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PMC11607638
Quantitative analysis of calcium peak areas above baseline (per 10 min) from multiple experiments (number shown in brackets at each data point), with typical calcium traces shown in panels (C–H), is summarized (I) (N = 5–7).
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PMC11574271
The addition of MSP further altered cell morphologies from spindle to elongated and polygonal shapes, which appear to have the characteristics of mesenchymal cells.
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PMC11218145
Current therapies are unsatisfactory and novel cures are urgently needed.
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PMC11306331
An additional benefit of optogenetic control is the ability to apply inputs with high spatial precision to nucleate or dissolve droplets at particular positions within the cell.
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PMC11739696
Fig. 3Transmission electron microscope (TEM) imaging of Co3O4NPs.
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