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PMC11180402
Additionally, high expression of SOX2 significantly enhances the growth and invasion of ovarian cancer, breast cancer, and hepatocellular carcinoma cells .
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PMC11194678
We sought to investigate whether excessive STAU1 LLPS-mediated translational enhancement of mTOR ultimately resulted in autophagy dysfunction.
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PMC9105697
To enable detection of minute amounts of SS tumor DNA with extreme accuracy, we investigated whether addition of point mutations to the panel increases sensitivity.
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PMC11655498
Although the deletion of GRP78 does not affect the expression of EBV cleavage genes, it reduces the production of viral particles (Chen L. -W. et al., 2021).
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PMC7823217
Therefore, design stage is key for generating optimal and specific 3D cancer tissues representative of physiological tumours.
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PMC10490530
In the SKOV3NPp cell, a highly significant p53 stabilization effect was evident in the presence of doxorubicin, but this effect was somewhat less pronounced in both doxorubicin and TNFα (Supplementary Figure S7a).
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PMC11225860
During metaphase, TPX2 localizes and allosterically activates AK-A. The allosteric binding of TPX2, induces a conformational change that not only activates AK-A, but also prevents deactivation through phosphatase activity .
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PMC6684588
Data are means ± SEM (n = 7–11). ***
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PMC8633974
After formulation, rLNPs were collected and immediately diluted in 40x volume of PBS and subsequently concentrated using an Amicon® Ultra-15 (Millipore® # C7715, MWCO 10kDa) centrifugation filter to remove any residual ethanol from the formulation.
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PMC11343332
The migration distance of cells in the pycnogenol group decreased compared with that observed in the control group (Figure 5).
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PMC9454178
The majority of GISTs harbour activating mutations in KIT (75–80%) or platelet-derived growth factor receptor alpha (PDGFRa) (10–15%) [3–5].
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PMC11066331
Fig. 4 Reduction of batch effects using the median-centered data; PCA of non-centered (A) and median-centered (B) spectral data recorded from SKOV3scrambled shRNA and SKOV3TUSC3 shRNA in technical pentaplicates from five independent measurements.
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PMC9429973
Methods: CARDINAL was an open-label, single-arm, multicenter study for patients with a recent blood transfusion.
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PMC11380454
Many malignant cells express PD-L1.
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PMC10419319
Table 1 provides the primer sequences.
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PMC11666785
This indicates that DoL of SMLM is relatively larger than corrSMLM.
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PMC10840195
Target cells were collected, and the total cell lysates were prepared separately.
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PMC10502403
In our study, αβ-TCR-transduced γδ-T cells showed promising persistence in vitro and in vivo.
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PMC7841067
Tumor volumes were measured with calipers every 1 week and calculated according to the following formula: V = L × W /2.
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PMC11615218
It is well-established in a murine model that CAR-T cell manufacturing from purified TN and TSCM populations results in longer and enhanced anti-tumor activity, and reduces the tendency of the cells to cause cytokine release syndrome .
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PMC10882807
For RNase R treatment, 1 µg of total RNA was incubated with or without 0.1 µL RNase R (20 U/µL) and 1µL 10X Reaction Buffer for 0.5 h at 37 °C.
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PMC11320084
In conclusion, NNT1 expression was increased in LC tissues and cells.
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PMC9429973
Patients of Ph+ve ALL and CML were prospectively screened for inclusion (minimum 1 month of drug intake) and exclusion criteria (poor compliance, inappropriate sample collection).
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PMC11615218
Additionally, recent evidence suggests that CAR structure may impact the metabolic program in CAR-T cells.
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PMC11659921
Furthermore, we noted significant differences in immune infiltration and immunotherapy response between cluster 1 and cluster 2.
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PMC11779876
Lymphomas have traditionally been viewed as neoplasms that emerge from mature cells.
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PMC9429973
Of 14 related SAEs, 4 were Grade 2, 9 Grade 3 and 1 Grade 4 (thrombocytopenia).
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PMC11310713
In this study, we tracked the changes in BMD, BMC, and fat in tissue during the experimental period.
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PMC11548041
The use of an in silico modeling approach to design and screen aptamer candidates that bind to a protein target of interest provides an alternative approach that has already led to the discovery of several high affinity EpCAM-targeting RNA aptamers .
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PMC11721295
The average number of lesions was corrected by the size of the lung section (whole lung, half, quarter of the lung) per experimental group by dividing the number of lesions for whole or half lungs.
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PMC11697703
We found that whereas the putative promoter region upstream of the miR-193b∼365 cluster is accessible in callosal projection neurons, it is inaccessible in corticospinal projection neurons (Figure 1B).
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PMC10578720
Meanwhile, other metabolite classes, namely, diazines, organic phosphoric acids and their derivatives, as well as keto acids and their derivatives, exhibited significant differences between groups (Figure 6E).
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PMC11578343
This could potentially aid in identifying differential phenotypes in the viscous G″, as higher frequencies better capture viscous behavior.
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PMC11474209
This is why mutations in the mtDNA can lead to defective energy production, decreased ETC that produces ROS, and increased apoptosis.
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PMC11291490
To elucidate the evolutionary relationship of duCD40L across various species, an evolutionary tree was constructed employing the amino acid (AA) sequence of CD40L (Supplementary Fig. 1a).
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PMC11788920
Stabilizing this PQS with small molecules reduced transcription by approximately two-fold while destabilizing the GQ with site-specific sequence mutations enhanced transcription by approximately three-fold in a Burkitt’s lymphoma cell line .
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PMC11394112
U2932 and VAL cells were plated in 6-well plates at a cell density of 2.5 × 10/mL and equilibrated overnight.
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PMC11279598
Animals were randomized by weight and tumor size at the start of the experiment, with 5–7 animals included in each treatment group.
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PMC11787381
Currently, AD treatments predominantly comprise AChE inhibitors (AChEIs), which offer symptomatic relief by temporarily restoring the loss of cholinergic neurotransmission, thereby moderately alleviating cognitive disorders.
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PMC9429973
Aims: To provide the Mayo Clinic experience in treating 16 patients with relapsed POEMS syndrome with novel agents (daratumumab, carfilzomib, pomalidomide, and elotuzumab).
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PMC5811757
Subsequently, down-regulation of ABCB1 led to increased doxorubicin drug sensitivity in A2780/ADR cancer cells.
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PMC10761218
The plates were then incubated for 1 hour at 37°C in a 5% CO2 incubator.
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PMC9676986
This result suggests that dual inhibition can enhance the reversal of lineage plasticity.
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PMC11750696
For example, certain UPR molecules, such as CHOP, can reduce naïve T cell numbers and influence their quiescence (28), while IRE1 promotes CD4 T cell activation (29).
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PMC11711063
Pathway and gene network analysis of genes downregulated by Bex + Carv and induced by ZG16B. (
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PMC11765678
While ER may also be a substrate for BCRP , our studies indicated that BCRP-expressing MCF-7/MXR cells were more sensitive to both ER and RSL3 compared to the parent MCF-7 cells (Figure 1B,D), suggesting that ER was not a substrate for BCRP in MCF-7/MXR cells.
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PMC11790599
Instead, they develop traits associated with late endosomes, presumably enroute to a terminal fusion event.
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PMC5363531
MPM mortality rates are estimated to increase by 5–10% per year in most industrialized countries, with an expected peak over the period 2020–2050 .
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PMC10142392
This finding indicated that multi-arm structures are more suitable than other morphologies for the efficient administration of drugs.
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PMC8540611
This effect was not seen in the general population, but in the population of FAM-positive cells the level of early apoptosis significantly changed from 5.9 ± 1.0% to 11.2 ± 1.1%.
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PMC10748106
The warning leverage (h*) is calculated as h = 3 p/n, where n is the number of molecules and p is the number of descriptors in the model plus one.
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PMC11509224
The Spongia sponges produce the most diterpenoid molecules among all genera, accounting for 27%.
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PMC8839885
In addition to chemoresistance resulting from alteration within the cancer cells , an increasing number of studies have also implicated tumor microenvironments (TME) in cancer chemoresistance .
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PMC11638255
Significance was calculated using a two-tailed Mann–Whitney U test with p-values displayed in the figure.
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PMC9429973
Accordingly, genes associated with mitochondrial biogenesis were upregulated in EMCN HSCs as compared to EMCN HSCs, indicating that these cells are metabolically more active.
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PMC11789597
Bortezomib, daratumumab, elotuzumab, lovastatin, simvastatin, bafilomycin A1, V9302, and CB‐839 were purchased from Selleck Chemicals (Houston, TX, USA).
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PMC11283030
Among these ccRCC tissues, 4 pairs of fresh frozen cancer and adjacent non-cancerous tissues were subjected to western blotting (WB) analysis.
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PMC11632064
Related to Fig 6. (
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PMC10198699
Second, she can claim all profits from anyone who sold the cell line, using a general enrichment action. (
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PMC11350568
Determination of PTK7 levels on CCRF-CEM cell membranes post-incubation with AptGs and aptamers by flow cytometry.
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PMC11773391
Immunofluorescence staining was used to detect the effect of vMF on the level of the TMZ‐induced DNA damage protein γ‐H2AX (Figure 6B).
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PMC10212663
The proliferation, invasion, and migration capacities of KRAS‐mt LUAD cells were evaluated.
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PMC7039683
Less than half of the NFRs enriched in GFP-positive cells were marked by H3K27Ac in whole embryo lysates from near the same stage (Bogdanovic et al., 2012).
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PMC10198699
Accordingly, HBM and the genetic information that it contains fall outside the scope of POPIA.
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PMC11775197
This process involves many transcriptional co-activator interactions, including PPARγ co-activator-1 (PGC-1) α and PGC-1β.
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PMC10975211
Although the inhibition or cancer-killing mechanisms are uncertain, there are similarities to those of antimicrobial activity, presenting both cell wall disruptive and non-disruptive mechanisms .
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PMC11740399
According to previous reports, caveolin-1 is known to play critical roles in vesicular endocytosis.
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PMC11803149
Data are pooled from 2 (A) or 4 (B) independent experiments. (
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PMC10748106
This agrees with our QSAR equation since the negative coefficient indicates that increasing the PSA value of the iridoids compared to Genipin will negatively affect its cytotoxic activity against the HeLa cell line.
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PMC11472569
Platelet-derived growth factor receptor-beta (PDGFRβ), a critical factor in resistance, is enriched in EVs released by melanoma cells that are resistant to the BRAF inhibitor PLX4720.
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PMC9780037
Similarly, several protein-based and nanoparticle-based systems have been developed for the therapeutic delivery of cyt c to cancer cells.
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PMC11298021
Other studies have reported that rapamycin can sensitize T-ALL cells to conventional chemotherapeutic agents by enhancing their cytotoxic effects.
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PMC9966931
Organic extracts of C. verum, of which aromatic compounds and carboxylic acids such as cinnamic and benzoic acid are reported as major compounds, also exhibit numerous bioactivities .
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PMC8609870
Recurrent spontaneous abortion (RSA) is one of the common complication of pregnancy, bringing heavy burden to the patients and their families.
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PMC4839679
Mutation of PBRM1 is believed to be an early event in carcinogenesis, however its function as a tumor suppressor is not understood.
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PMC9884169
Moreover, TEM revealed that after knockdown of MCT4, the mitochondria of 5637 cells shrank, were rounded, and vacuolized following erastin treatment (APExBIO) (Figure 2(c)).
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PMC11806818
As shown in Fig. 7B, probe P1 was immobilized on the surface of MoS2-Au@Pt nanozymes via Au-S bonds to form a MoS2-based signal amplified nanoprobes (MNP).
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PMC10204952
For the HCC1937 cells (Fig 3C), significant nucleic alteration was also observed at both S1P concentrations.
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PMC11761919
n=3. *
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PMC11519567
τ(SS18) = 11.76 s, τ(SS18-SSX) = 84.85 s; Data are mean±s.d.,
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PMC11782508
Additionally, its anticancer properties were determined using the MTT assay and cell cycle analysis, revealing a preference for inhibiting the MCF7 breast cancer cell line where breast cancer is most common in Egypt.
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PMC4443654
Overall, more highly ranked features are shared between the two relatively differentiated, hematopoietic cell lines (GM12878 and K562), with the pluripotent ESC line (H1 hESC) showing more distinct characteristics.
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PMC11457557
They discovered that these variations were significantly more strongly associated with CAD in diabetic patients than in non-diabetic ones.
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PMC11172027
This is in contradiction to several previous studies, in which the restriction of methionine significantly reduced cell growth in cancer cells .
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PMC10976516
Given the variety of biological tools at our disposal and our expanding knowledge of tumor biology and cell migration, it is conceivable that, by biologically modifying the carrier cells and/or OVs, a significantly improved boost in cell trafficking and systemic OV delivery can be attained.
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PMC6468656
An investigation of the synergistic effect of hepatocyte growth factor (HGF) and vascular endothelial growth factor (VEGF) in human endothelial cells revealed the increased expression of human AURKA mRNA in cultured cells 24 hours after initial treatment .
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PMC9429973
For I+V CR at any time was 93.4%.
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PMC10490530
Finally, the effect of modulators on the PIK3CA promoter regulation was measured by FLuc2 reporter activity.
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PMC11023271
We extended the analysis to two tumorigenic keratinocyte cell lines, A431 and SCC-1, and found that the reduction of RIPK4 mRNA by FBS was recapitulated in these lines (Fig 1C and 1D).
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PMC10652261
At the end of the incubation period, absorbance values at 420 nm, determined using the Cytation 3 Cell Imaging Multi-Mode Reader (BioTek, Santa Clara, USA), were read as 7 replicates (7 wells, 1 blind) for each concentration.
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PMC8735881
The inhibitory activities of GPI-scFvs against a panel of replication-competent HIV-1 isolates (A), the “global panel” of HIV-1 pseudoviruses (B), and viral Env-mediated cell-cell fusion (C) in Table 1 were summarized for convenient overall view.
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PMC9429973
The prognostic impact of DEL, and BCL2 and MYC overexpression within treatment arms was also explored.
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PMC9727330
The total cellular RNA was obtained using TriZol (Invitrogen, USA) and purified using an RNA purification kit (Invitrogen, USA).
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PMC6114978
LATS1 expression is decreased in 1 of 12 sarcoma cell lines (8%).
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PMC9429973
The parental cell line showed dissociation of antiapoptotic complex MCL-1/BIM after exposure to MCL-1 inhibitor.
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PMC9917080
The method of preparation, doping, and characterization of the obtained nanoparticles and nanocomplexes are described in detail in our previous work .
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PMC11695623
p < 0.05,**p < 0.01, ***p < 0.001.
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PMC11224206
Methodological problems and heat conductivity have also been explored in a fascinating study by Song et al. who reported that thermal conductivity differed within single human cells (HeLa, MCF-7 and MCF-10A) with heat transfer greater at the periphery than the centre.
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PMC11566417
Research into common infections of cows, such as mastitis, is imperative to the livelihood of many farmers.
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PMC11791432
A total of 1 × 10 Cells were plated onto each plate of 6-well plates and cultured in the incubator for 10–12 days.
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