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OTAR3088
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BioData-CellLine_annotated

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PMC11380454
PD-L1 expression by cancer cells involves various pathways, all of which activate NFκB, which then binds to the PD-L1 promoter to produce PD-L1.
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PMC11412721
Pre-tumoral splenic cells from Trp53Eμ-Myc males exhibited a higher expression of Ackr4, encoding an atypical chemokine receptor with tumor suppressive effects.
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PMC11509309
After 24 h treatment of CHO-K1 cells, luciferase activity was measured following the addition of 50 µL of Steady Glo lysis buffer (Promega, Madison, WI, USA, #E2510), using a Varioskan microplate reader (Thermo Fisher Scientific, Waltham, MA, USA).
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PMC6379402
The differential expression of a gene between the cancer and the paired control tissues, log2FC, is defined as the difference between the median of the log-transformed expressions in the cancer tissues and the median of the log-transformed expressions in the paired control tissues.
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PMC10994876
The impact of YAP5SA overexpression on the production of both total protein and EPO protein was assessed.
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PMC11727062
This effect significantly inhibits the proliferation of A375 cells and induces apoptosis.
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PMC9429973
Of those, 17 pts remained CH MRD in all samples (median samples per analyzed mutation 6, range 1-13).
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PMC11240448
As a result, these cells are sensitive to EGFR inhibitors and resistant to MEK and ERK inhibitors, which agrees with the experimental data .
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PMC11697703
Importantly, these results are consistent with previous work demonstrating decreased dendritic branching by layer II-III neurons in MapK8 KO mice compared to wild-type.
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PMC8633974
48 hours post electroporation, cells were analysed by flow cytometry and the results were calculated as % GFP-positive of gated singlet cells.
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PMC11787355
k was analyzed with two-tailed paired t-test.
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PMC11790971
Cell line predictions for monoclonal wells and artificial pools in different passages are shown in (g–i), (j–l), and (m–o) for passage 0, passage 1, and passage 2, respectively.
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PMC9884169
All results were obtained from three independent experiments performed in triplicate.
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PMC7369657
Although mice brains were stained with H&E and showed no significant histological lesions, this result may be because CQDs cannot get through the blood-brain barrier.
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PMC10538569
Representative images by Amnis ImageStream Mark-II of single cell GPI-GFP CEMss cells, DiD dyed iDCs, GPI-GFP transfer to DiD dyed iDCs and cell-cell conjugates between DiD dyed iDCs and GPI-GFP CEMss cells.
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PMC11394730
Studies have revealed that the active site, which in turn prevents tumor growth and metastasis, is the ortho-dihydroxyphenyl structure on the B-ring .
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PMC6617630
g The effect on P21, H3K27AC, BCL-XL, and MCL-1 expression was determined by western blotting.
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PMC8973725
ZNF677, which comprises C2H2-type ZFs and a KRAB domain and is a member of the KRAB-ZFP family, is located in the chromosomal region 19q13, where a frequent loss of heterozygosity occurs in cancer .
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PMC9429973
Methods: Our training cohort (TC) included CML-CP pts diagnosed between 2003-2018 receiving imatinib as a first-line TKI therapy.
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PMC9261184
If the engines were kept at 80%, this would approximately halve methane emissions and result in much more efficient engine operation.
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PMC11321678
RNA scope images of each NTR gene marker in representative samples from different subgroups.
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PMC11699178
Further analysis involved extracting data for ovarian serous cystadenocarcinoma from The Cancer Genome Atlas (TCGA) and corresponding normal tissue data from the Genotype-Tissue Expression Project (GTEx) (TCGA_GTEx-OV).
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PMC9429973
Patients’ most trusted sources for information about COVID-19 were healthcare providers and scientists for both groups (90% and 86% reported high levels of trust, respectively).
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PMC11767725
If validated, phage therapy could offer a targeted, microbiome-focused adjunct to existing anti-inflammatory and immunomodulatory treatments, potentially improving outcomes in patients who do not respond well to current therapies .
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PMC10507284
Although immunotherapy has presented excellent effects in treating some solid cancer, such as melanoma and bladder cancer, , , its clinical results are still unsatisfactory in more types of multiple tumors, including STS.
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PMC8956657
An earlier study suggested that an altered ORF4b:IMPα interaction modulates the efficiency of PDE domain-mediated inhibition of the OAS/RNase L pathway.
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PMC11680391
This suggests that the dairy farmers and herd veterinarians perceived the communication of the udder health consultation quite differently.
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PMC11588008
Extracellular regulated protein kinase (ERK) 1/2 is considered the top biological factor that participates in oxidative and ER stress in the Post-Intracerebral Hemorrhage Stroke Rat Brain model .
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PMC8270637
The qPCR results also showed that TGF-β1 significantly increased the mRNA levels of PD-1 and CTLA-4 ( Figure 1C ).
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PMC11345828
Indexing, integration and scaling were performed with HKL2000 (HKL Research), phasing by molecular replacement with Phaser (CCP4) using the structure (PDB: 9BCG) as a model, refinement used Phenix.
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PMC10919056
This study developed a clinical nomogram incorporating patient clinicopathologic characteristics, risk groupings, and GJA5 and GJB1 expressions.
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PMC11794568
It is known that rotenone is a common respiratory complex I inhibitor, and we investigated whether rotenone could reverse the effect of CRIP1-regulated mitochondrial biogenesis by adding rotenone to CRIP1-silenced melanoma cells.
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PMC11615218
Consistently, studies have also shown that higher frequencies of inhibitory receptors in leukapheresis T cells, peripheral or bone marrow T cells, or tumor microenvironment T cells correlate with worse responses in CAR-T cell-treated patients [26–28].
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PMC11721064
However, phosphorylation levels of ERK and P38 MAPK did not exhibit significant differences between LN-KS KPCs and control KPCs (Additional file 1: Fig. S1G and S1H).Fig.
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PMC11656048
These data confirmed that shikonin induced ferroptosis in OS cells via facilitating Nrf2 ubiquitination and degradation.
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PMC8973085
The structures are usually diverse from what we have seen in comparative structures in which the methyl group and fluoro atom are linked to aromatic ring in the pyridine ring system.
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PMC9429973
N. Ruechel, M. Oldenburg, S. Janssen, A. Pandyra, L. Wei, D. Hein, V. Jepsen, U. Fischer, J. Hauer, F. Auer, A. Beer, O. Adams, C. Mackenzie, M. Jaeger, M. Netea, A. Borkhardt, K. Goessling Pediatric Oncology, Hematology and Clinical Immunology, University Hospital Duesseldorf, Duesseldorf; Algorithmic Bioinformatics, Department of Biology and Chemistry, Justus Liebig University, Gießen; Department of Molecular Medicine II, Medical Faculty, Heinrich-Heine University, Duesseldorf; Department of Pediatrics and Children’s Cancer Research Center (CCRC), Technical University (TU), Muenchen; Pediatric Hematology and Oncology, Department of Pediatrics, University Hospital Carl Gustav Carus, Dresden; Institute for Virology, Medical Faculty, University Hospital; Institute of Medical Microbiology and Hospital Hygiene, University Hospital Duesseldorf, Duesseldorf, Germany; Radboudumc, Nijmegen, Department of experimental internal medicine, Radboucumc; Radboudumc, Nijmegen, Department of experimental internal medicine, Radboudumc, Nijmegen, Netherlands Background: B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is the most common subtype of childhood leukemia with a peak during early childhood when children are exposed to viral infections.
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PMC11552389
Different fields of view were randomly selected based on the observed DAPI signal for quantification purposes.
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PMC11773391
Western blotting was performed as previously described .
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PMC10571053
We thus sought to characterize the interactions of FINs with P-gp and ABCG2, which may provide information regarding oral bioavailability and brain penetration and predict drug-drug interactions.
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PMC11190538
Subsequently, the physicochemical properties of nanoparticles were evaluated.
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PMC6182045
The final 3E5 MGAT1 CHO TZ97008 cell line expressed approximately 1200 mg of TZ97008-rgp120 in an 11-day shake flask culture.
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PMC11806182
Progesterone, a hormone frequently used in UCEC treatment, was observed to down-regulate the cell cycle while up-regulating primary metabolism.
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PMC11803149
Epas1-Crispr treatment also did not affect the abundance of CD62L CD44 central memory cells ( Figure 6C , Supplementary Figures S4C–E ).
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PMC11551844
Eqn (2) can be simplified as follows:3where D is the average diameter of the spherical particle (obtained by TEM measurements). (
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PMC9429973
Aims: TKI-induced bone marrow aplasia is a rarely described complication of TKI.
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PMC9587298
To select non-cytotoxic concentrations of elderberry extracts and cytotoxic concentrations of MGO (IC50), the exposure of cells to elderberry extracts (50 – 750 µg/mL) was first evaluated for 24 h and 48 h incubations in both cell lines.
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PMC11486946
The device can also be applied to normal microscopy, especially with high magnification.
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PMC11365427
Our research also clarifies the role of ATF3 in MM apoptosis induced by phenylalanine deprivation.
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PMC9243326
2021; Wu et al., 2021).
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PMC11468365
Finally, for the MultiComb model when attention and relation tasks mechanisms are combined it states the art over the previous three compared models.
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PMC10936243
Participants claimed that having good financial support could help them to improve the welfare of cat patients in clinics. “
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PMC11769522
Similarly to human AD, several cytokines (including IL-4, IL-13, IL-5, IL-13, IFN-γ, and TNF-α) have been reported to be upregulated in spontaneous or experimentally induced AD in dogs .
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PMC11367146
Confocal microscopy image of NF-kβ.
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PMC11596967
This organism’s unique ESDSA mechanism is enhanced by unconventional HR proteins such as RecA and UvrD and Deinococcus-specific proteins likr DdrA and DdrB, setting it apart from typical organisms .
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PMC11487720
COS7 cells were UV irradiated and cultured at 4, 22, or 37 °C for various durations.
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PMC10094712
CytoCalcein 450 was used to detect healthy cells and the cells were visualized with the violet channel (Ex/Em = 405/450 nm).
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PMC2196094
The isolated rat proteases were numbered according to their mouse counterparts: RMCP-5 (MMCP-5), RMCP-6 (MMCP-6), RMCP-7 (MMCP-7), and rat carboxypeptidase A. However, the nomenclature of the rat counterpart to MMCP-4, RMCP-1 cannot be changed due to historical reasons.
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PMC11753435
As a result, numerous approaches have been developed to leverage protein-based binding domains for the design of intracellular protein degraders.
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PMC9325715
Further results of this group were presented in Booyjzsen et al. work where the fibrillation process for recombinant human serum transferrin was presented.
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PMC11747467
From the beginning, artemisinin (ARS) and its derivatives, including ART, have been used as standard treatments for malaria worldwide (41, 42).
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PMC8143558
Dermal toxicity tests that were done for saponins from Sapindus mukorossi Gaertn showed that they are not toxic to the skin .
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PMC11011837
The overall metabolic and lipidic profiles indicate a resemblance between Jurkat and Molt-16.
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PMC10523483
NRF2 is activated in the stressful environment within tumor (13), and tumor-driving mutations like Kras and BRAF directly increased NRF2 expression to elevate NRF2-mediated antioxidant program (41).
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PMC11300085
It is found that OC patients have high levels of chemerin in their ascites, which is higher than serum levels .
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PMC9429973
These treatments affect the patient profoundly due to theiradverse effects.monitor the dynamic changes of symptoms, analyze the cluster phenomenon, and explore the dynamic changes of symptom groups and their correlation with quality of life(QOL), in order to provide reference for medical staff to formulate efficient symptom management strategies.
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PMC11767793
A wider, interlaboratory study, that includes additional kinds of cell viability assays, would be essential to validate these controls as appropriate for reference materials.
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PMC11026382
The initial velocity of DHFR was measured spectrophotometrically by monitoring the consumption of NADPH and DHF (decrease in absorbance at 340 nm, Δε340 = 13.2 mM cm).
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PMC10812665
The accumulation plot display was adopted, from , as this has become a standard in the display of toxicogenomic responses .
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PMC11700247
Data are representative of 3 independent experiments.
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PMC11568601
However, the PERK expression was not affected by TGT in our study.
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PMC11541241
They revealed that MoSNT2 mediated epigenetic control of gene expression through binding the acetylated H3 histone and recruiting histone deacetylase.
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PMC7351993
As shown in this equation, the sort purity varies, depending on the throughput, sort window, and target-particle concentration.
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PMC11252033
All data were analyzed using GraphPad Prism v7 software (GraphPad Prism La Jolla, CA, United States).
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PMC11337594
At present, surgical resection, chemotherapy, targeted therapy and immunotherapy represent the primary modalities of treatment for melanoma .
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PMC10728200
MG132 (5 μM) was added for stabilizing GPX4.
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PMC9429973
The patient did not develop autoimmune neutropenia and AIHA at his relapse.
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PMC10877303
nHowever, the active site for the 3CL from MERS-CoV was obtained from the PDBsum database, which mentioned twenty-one active sites.
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PMC8759873
We aspirate supernatant into a new Eppendorf tube add 600 g of -20C precooled isopropanol to each tube.
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PMC9429973
The main reason of maintenance withdrawal was disease progression.
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PMC8193813
Average plume NOx concentrations were 0.88 ± 0.32 ppm at Midland and 1.22 ppm and 2.41 ppm at the two St. Charles boilers, with an average RSD of 37%, 36%, and 12%, respectively.
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PMC11453018
B Heatmap illustrates the expression profiles of the top five genes from each group identified by NMF clustering.
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PMC9268620
The spectroscopic values of nordamnacanthal and damnacanthal were verified with the literature values .
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PMC11252033
In the present research study, we demonstrated that ASA inhibits the binding of CryZ to the mRNAs of the anti-apoptotic Bcl-2 and Bcl-xL genes.
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PMC9429973
While the world is entering the second wave of COVID-19, clinicians, particularly who manage old-age individuals, need to have insight into this dreadful but manageable complication of COVID-19-related disease.
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PMC9429973
Shiga, Japan Background: The combination therapy of hypomethylating agents (HMAs), azacytidine (AZA) and decitabine (DAC), with venetoclax (VEN), a selective BCL-2 inhibitor, have revolutionized the outcome of elderly patients with acute myeloid leukemia (AML), which have demonstrated the potential effect of HMAs as a combination therapy with molecular targeting agents for myeloid malignancies.
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PMC9509578
The nanocarriers were used at 37 °C (normal body temperature), thereby inhibiting MDR1-mediated cancer drug resistance.
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PMC7802142
Blue indicates nuclei.
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PMC9429973
Safety analyses in all trials included monitoring of thrombotic events.
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PMC9429973
Methods: Data from 1364 consecutive subjects were randomly-assigned 2:1 to training (n=909) and validation (n=455) datasets.
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PMC10470467
The DepMap results showed that CHMP7 is critical for the growth of ES cells.
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PMC8735881
As shown above, GPI-10E8 could endow modified cells with potent resistance to diverse HIV-1 isolates.
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PMC7342409
The detection of alterations in the MAPK pathway in GISTs would be innovative and could be relevant in receptor tyrosine kinase inhibitor resistance or autophagy.
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PMC11590870
Colorectal cancer has been one of the most used models for peptide studies since although enterocytes absorb free amino acids as well as di- and tripeptides through the Ppt1 HfI/peptide cotransporter, these cells can only absorb 0.1% of longer peptides, with the majority going to the large intestine .
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PMC10965315
The individual data points and significant p‐values are shown in each column, and the data are represented as mean ± SD.
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PMC9220170
Another possible explanation for the lack of influence of SELENOM-KD on the proliferative properties of cancer cells is the increased expression of SELENOK and SELENOT, two other selenoproteins localized in the ER.
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PMC10671321
To understand its molecular role, the main approach has been to introduce the sequence of the variants in a WT ColQ coding sequence and express the cDNAs in heterologous cells.
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PMC11388384
Understanding how different transport mechanisms contribute to morphogen gradient formation requires observing and perturbing SHH delivery mechanisms in a context where the gradient can be quantitatively measured.
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PMC11705067
However, resistance to autophagy is largely responsible for the failure of these therapeutic strategies13.
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PMC11604768
Finally, to eliminate redundancy in our candidate list, we removed any resulting motif for which the entire sequence was represented within another motif, resulting in a total of 325 unique binding motifs (Supplementary Data 2).
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