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BioData-CellLine_annotated

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PMC11711663
In this study, we utilized an ensemble feature selection method to refine the input dataset for Cox proportional hazard modeling, addressing challenges associated with high-dimensional data.
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PMC11546117
Images acquisition was obtained using a Zeiss Axioplan 2 microscope, equipped with a Hamamatsu ORCA-spark CMOS C11440-36U camera (Göttingen, Germany).
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PMC9429973
Aims: To report 2-year sutimlimab efficacy and safety from the CARDINAL Part B extension.
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PMC9848491
The ss-GSEA results demonstrate a significant relationship between the prediction signatures and dendritic cell activation, immature dendritic cells, immune status of the Treg, and dendritic cell activation.
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PMC9268183
Altogether, these findings contribute significantly to improve our understanding of traditional plant uses related to cancer management, but also emphasise the power of in-depth surveys at regional and local levels to uncover new potential candidate species, and thus complement global initiatives in cancer research.
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PMC7039683
Heatmap plots of ATAC-seq and E14.5 mouse facial prominence H3K27Ac ChIP-seq (Klein and Andersen, 2015) in tissue-specific NFRs. (
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PMC11576293
As shown in Table 6, the S-alkyl derivatives (19 and 26) showed the lowest p values.
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PMC10758402
All cells were incubated at 37°C in a 5% CO2 humidified incubator and routinely tested for mycoplasma contamination by Hoechst staining and PCR (Diamed, Mississauga, Ontario, Catalog # ABMG238).
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PMC11463018
HR-MS (ESI) calcd.
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PMC10125312
Although this correlation will be prone to fluctuations depending on the laser setup, with the settings used throughout our research (3 W/cm, 3 min, 808 nm), a positive correlation was established between the number of AuNR-PEG incorporated and temperature (r = 0.85).
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PMC10443665
The effects of tragacanthin on the viability of CCRF-CEM cells.
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PMC9429973
Carbogen gas mixture (95% O2 and 5% CO2) & nicotinamide (an amide of vitamin B3) have been recently studied as a radiosensitizer in solid tumors & also improve tumor oxygenation level.
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PMC10366908
Adjuvants are mixed and injected along with antigens to prevent catabolism.
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PMC11721295
Data were analyzed through relative quantification with the –ΔΔCt method.
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PMC11277157
This was further confirmed in prostate cancer .
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PMC3035438
Even after purification with protein G columns, the specificity of chimeric IgG from clone #14 stayed at a much lower level than the IgG from clone #3, although the concentrations of IgG were similar (Figure 3D).
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PMC11525293
Furthermore, thalidomide (Thal), a small molecule drug with many years of history known to cause misery, became a game changer for its multifaceted pharmacological effects such as immunomodulation, anti-inflammation, anti-angiogenesis, and antiviral effects .
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PMC11476004
At the site of errors, exchanges take place between chromatids of the same chromosome.
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PMC10887351
Moreover, the involvement of β3-ARs in immune cells has been studied.
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PMC11565047
Each treatment was done in triplicates, resulting in a total of 12 samples.
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PMC10291556
The results suggest that these Pt(IV) complexes exhibit mechanisms of action typical for Pt(II) complex 1 and DCF, simultaneously.
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PMC11761919
These results suggest that the livers of chickens in the four groups immunized with Fiber2-expressing E. faecalis, especially Micro-E/Fiber2-PINs and Micro-E/Fiber2-inulin, effectively inhibited liver injury caused by FAdV-4 infection.
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PMC11683240
The separation was performed at a flow rate of 12.23 ml/min using the gradient program (min/% B) 0/5, 5.09/5, 28.71/25, 49.55/50, and 70.39/100, being A, 0.1% TFA in water, and B, 0.1% TFA in acetonitrile.
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PMC11626627
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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PMC11684269
The key enzymes and metabolites involved in T cell metabolism metabolically and epigenetically modulate T cells' differentiation, activation, and effector functions, thereby being capable of modulating kidney immune homeostasis.
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PMC9429973
The ACTIVATE-T/LTE analysis assessed transfusion response in the LTE, and transfusion-free duration among pts from ACTIVATE-T who achieved transfusion-free status.
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PMC11721587
The resulting agarose were subjected to sequential Fu(Ulk3)/CK1 kinase assay before finally used as substrates in SUMOylation assay.
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PMC9429973
Methods: This Phase 1/2, single-arm, open-label, multicenter study will enroll pts aged ≥1‒21 years with Ph+ ALL, Ph+ mixed-phenotype acute leukemia, or Ph-like ALL (United States only) who have a targetable kinase-activating lesion and whose disease has relapsed or is resistant/intolerant to ≥1 prior therapy with a BCR::ABL1–targeted TKI or has a BCR::ABL1 T315I mutation.
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PMC11609529
Focus formation, indicative of cell transformation, was evaluated by staining with crystal violet 15 days post-transfection.
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PMC11489351
Notch1 is a unique signaling molecule and the pathway lacks an amplification step during signal transduction (51).
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PMC9429973
Bone marrow (BM) and peripheral blood samples were obtained at screening, and during weeks 9, 17, 25, 33, 41, 53, and every 24 weeks thereafter, and at end of treatment and during EFS follow up.
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PMC11487720
In comparison, apoptosis occurred when UV/cold shock-treated L929S cells were cultured at 37 °C, and the cell thickness reached ~ 15 μm (Video S9).
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PMC6771295
One-way analysis of variance (ANOVA) and Tukey's multiple comparisons post-test were used for the analysis of data.
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PMC9512971
A limitation of this study is that the improvement of the ordinal scale of severity could not be evaluated correctly because most patients were hospitalized for daily viral testing regardless of the presence or absence of symptoms and were hence classified as grade 3.
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PMC9429973
In case an alternative donor was not identified in due time, a search for another donor was allowed.
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PMC11803918
Schematic illustration of tumor implantation and treatment schedule during antitumor study. (
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PMC9429973
An important limit of our case-series is that only 4 patients were auto-transplanted, so we have scant data on engraftment.
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PMC11515150
no significance) (bottom panel).
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PMC10988555
Moreover, deshielding of the H NMR signals of the methyl and amino groups from the ligands of complexes 2 and 4 was also observed upon coordination (Δδ H6 = 0.12 ppm, and Δδ H13 = 0.88 ppm, respectively), being found within their typical range values.
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PMC11055510
p < 0.05. (
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PMC10968586
Similarly, treatment of pancreatic ductal adenocarcinoma cell line PANC-1 with 10 μM, 32 μM, 100 μM, and 320 μM HT for 24, 48, and 72 h reduced cell viability in a dose- and time-dependent fashion; doses as low as 19 μM were able to induce apoptosis (as detected after 24 h), with caspase-9 and Bax upregulation, and MMP-2 and MMP-9 downregulation at mRNA levels after 72 h incubation .
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PMC11705067
Of note, the expression of both FDX1 and DLAT proteins was up-regulated when 786-O and A498 cells were co-treated with 30 nM elesclomol and 1 µM CuCl2 (Fig. 8D, 8E).
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PMC11772585
Combined with this study and the updated database for decoding the m7G epitranscriptome (http://www.rnamd.org/m7GHub2/index.html), we aimed to further confirm that METTL1 targets ATF4 mRNA for m7G modifications.
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PMC7709199
The choice of expression host takes into consideration the capability of the host glycosylation machinery to produce homogeneous glycans. (
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PMC11543885
Replace the Nigericin-containing medium with complete medium supplemented with 500 μM biotin-phenol and incubate the cells for 30 min at 37°C with 5% CO2.
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PMC11612794
Left: Mis12C is shown as a cartoon and color-coded, as indicated in the figure.
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PMC9429973
To investigate the mechanisms underlying the triple mutated mice phenotype, we looked BM leukemic samples from all groups both at transcriptional level by RNA sequencing (RNAseq) and at translational level (protein synthesis capacity of AML blasts) by Ribosome footprinting (Riboseq).
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PMC11640419
Conversely, moderate DNA degradation results in an increase in MDM2, which forms a p53 inhibitory complex.
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PMC9739791
Moreover, two of the five mice in the group were tumor-free by the end of the experiment.
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PMC10878518
Notably, high CAR and hTERT expressions were significantly associated with increased GFP expression between 24 and 48 h after OBP-401 infection (Fig 5).
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PMC2944824
The effect of Hr on apoptosis was examined in COS cells by forcing expression with a transfection protocol using Hr cDNA cloned into the Rk5 expression vector or the empty vector (mock) .
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PMC9429973
To initiate early preventive measures, newborn screening for SCD has been introduced in January 2007 in the Netherlands.
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PMC11711347
UV-Vis Spectral Analysis UV-Vis analysis of the Ni(II)ProDtc complex revealed an absorption band in the range of 212–248 nm, corresponding to the π →π * intraligand transition of the CS2 group (Figure 3).
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PMC9596868
E, F) Percentage cell viability after combination treatment with quercetin and MST-312 in OVCAR3 cells. (
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PMC11388384
We colored each displacement by the implied local diffusion coefficient using −2:+2 localizations to calculate the instantaneous implied local coefficient.
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PMC11791432
ANXA1 expression was observed to be correlated with molecular subtypes of poor prognosis in glioma.
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PMC11723947
Importantly, the adoptive transfer of ex vivo expanded polyclonal Treg protects the transplant from rejection in a dose-dependent manner (Fig. 1b, c).Fig.
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PMC6337547
In this review, we systematically summarized the biosynthesis, phytochemistry, and pharmacology of Chinese Salvia species, which provide a basis for its further development and utilization as a resource.
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PMC9429973
To further investigate the metabolism in each BMF syndrome, untargeted metabolomic screening of ERCC6L2 (n=4), SDS (n=3) and healthy control (n=3) fibroblasts in normal and low-glucose conditions was conducted by liquid chromatography mass spectrometer.
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PMC9429973
We finally correlated additional mutations and clinical data (blood count, splenomegaly, LDH, CD34+ circulating cells), overall survival (OS) and progression to blast phase (BP).
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PMC11718109
Characterization of synaptic function with the calcium indicator Fluo-4 showed basal spontaneous activity within the neuronal population (Fig. 1F, G) while acute depolarization with high K stimulation (30 mM KCL) induced a synchronized rise in calcium levels in these neurons (Fig. 1H, I).
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PMC11499381
Each image is one field of view within a well, imaged at 20x.
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PMC11740207
However, they do not express CD90, CD34, or CD45.
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PMC11708541
A number of aminopyridines have therapeutic efficacies that were either superior to or equal to those of 3,4-DAP.
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PMC11240052
We used the Dual-Luciferase Reporter Assay to further explore whether miR-211-5p directly regulates SIRT-1 expression via interaction with its 3′-UTR.
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PMC10142392
PCL-based materials have been studied for in vitro and in vivo biocompatibility and efficacy, and several PCL drug delivery devices have been approved by the FDA.
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PMC9841531
The reaction mixture was poured into ice-cold water (100 mL), and the respective target compound was extracted with EtOAc (2 × 100 mL).
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PMC9261184
Engine operational practices account for a broad range of safety, reliability, economic, and other environmental constraints, and further work in understanding how methane emission reduction opportunities could fit within these constraints is needed.
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PMC9164404
Obviously, Abplatin treatment resulted in more genetic disorders than cisplatin.
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PMC11023271
To test this, we knocked down RIPK4 in HaCaT and A431 cells by shRNA (Fig 7A and 7D; S4 Fig) and analyzed the cell cycle progression of these knockdown cells upon treatment by LPA, in comparison with the control cells (Fig 7B and 7E).
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PMC11706776
Data are derived from the GSE17679 (see Supplementary Table S2).
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PMC9429973
The principal cause of death was infection (27%).
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PMC11754784
The released Nb can block CD47/SIRP-α signaling between target cells and macrophages and eliminate “don’t eat me” signal to promote phagocytosis, therefore improving the specificity and biosafety of CD47 blockade and providing approaches for enhanced immune therapy.
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PMC9429973
Methods: Of 409 eligible patients in the JCOG0601 randomized controlled trial, we evaluated patients who developed sCNSi at their first progression.
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PMC11699178
1Analysis of ovarian cancer scRNA-seq data based on public databases.
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PMC6835428
Because of this structure, liposomes can entrap hydrophilic molecules in the water compartment and hydrophobic molecules in the lipid layers.
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PMC11323699
ID8 Trp53 Brca2.
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PMC11683240
Pertussis (whooping cough) is a vaccine-preventable but re-emerging, highly infectious respiratory disease caused by Bordetella pertussis.
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PMC5308810
MTS assays were performed on the cells 72 h after incubation with different concentrations (0–100 μM) of the peptide. (
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PMC11740399
Although a clinical study demonstrated that omeprazole, a proton pump inhibitor, was tolerable and inhibited the expression of FASN, no study proved that inhibition of FASN significantly prolonged the survival of patients .
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PMC11638764
However, our study is limited by its focus on protein expression without functional validation of these pathways, highlighting the need for further studies to explore the underlying mechanisms and potential clinical relevance of these findings.
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PMC11657695
Additionally, KCNA2 silencing led to a decrease in YAP expression at the protein level in two ES cell lines (Fig. 6E).
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PMC11740207
Consequently, somatic cells undergoing SDs can undergo a limited number of divisions since their telomeres eventually reach a critically short length, triggering cellular aging.
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PMC10831439
Nevertheless, this novel immunotherapeutic approach has still some considerable limitations such as production failure, side effects, relapse rates and limited use in distinct clinical situations such as allogeneic hematopoietic cell transplantation (HCT).
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PMC11522251
The colony formation area was evaluated and analyzed using ImageJ software. ****
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PMC11496728
A single protocol may improve protein expression; however, in establishing a novel expression system, a synergistic approach is necessary to address the bottleneck of low protein expression level and to improve the yield of recombinant proteins.
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PMC11551844
Taking into consideration the solubility of JDH, JDE and JC-2 in ethyl acetate, the reaction was performed using mixtures of ethyl acetate, absolute ethanol and distilled water.
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PMC11548041
Aptamers are short DNA or RNA sequences that adopt 3D structures and can bind to protein targets with high binding affinity and specificity.
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PMC11604830
A revolutionary applicative aspect is that the signal associated with these molecules can be used to track in vivo the biodistribution of the nanosystem and the delivery of its payload, for example, a drug, without the addition of any further contrast agents, with tremendous applications in the theranostic field.
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PMC11320834
The inhibitory properties were visualized using SynergyFinder 3.0 (https://synergyfinder.fimm.fi). *
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PMC11627398
Vascular barrier breakdown has been observed in patients with sepsis, as evidenced by the upregulation of angiogenic-related gene (e.g. VEGF-A) .
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PMC8143558
In Southern Africa, countries such as South Africa, Zimbabwe, Zambia, Mozambique, Lesotho, Namibia, and Swaziland are reported to contain a floristic wealth of saponin-containing plants.
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PMC5839394
Inverted phase-contrast micrographs Magnification 200X. (
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PMC10243817
Our study underscores a potentially previously unrecognized role of MEX3B in the pathogenesis of CRSwNP.
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PMC11095939
Although we identified Nedd4-mediated ubiquitination of Mecp2 in the cellular model of quiescence exit, we also measured the expression of Nedd4 at the early stages of liver regeneration (Figure 5—figure supplement 1D), which in turn may drive hepatocytes to enter the cell cycle by targeting Mecp2.
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PMC6268318
The results of this laboratory animal study indicate that MAG possesses analgesic and antiinflammatory effects in the mammalian models used.
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PMC9429973
The RFS at 1 and 3 years was 62% (95% CI 61-63%) and 45% (95% CI 43-47%), the cumulative incidence of relapse at 1 and 3 years was 18% (95% CI 11-28%) and 29% (95% CI 19-40%) and the TRM at 1 and 3 years was 21% (95% CI 13-30 %) and 28% (95% CI 19-39%) respectively.
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PMC9429973
Twelve pts were treated with convalescent plasma, 9 received corticosteroids and 1 tocilizumab.
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PMC11701801
The medium was then replaced with medium containing (or not) A-485 or CP-C27 and incubated for 24 hours.
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PMC9966931
Spectroscopic data were acquired in order to corroborate the structural features of the obtained hybrids.
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