OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC9429973	All CRS cases were rapidly relieved after conventional CRS intervention, including tocilizumab and steroids.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "CRS", "cases", "were", "rapidly", "relieved", "after...
PMC10729469	The X-ray tube was used at 150 μA and 75 kV. Each run obtained 512 projections with an exposure time of 230 ms.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC9577200	This work was funded by County Council of Västerbotten (BS), Cancer Research Foundation in Northern Sweden, Lion's Cancer Research Foundation in Northern Sweden (BS), and Kempestiftelserna (BS).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11615828	With this tool, we monitored the acute effects of IFT immobilization on cilia structure in real time.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "With", "this", "tool", ",", "we", ...
PMC11657744	Two-way ANOVA followed by Dunnett’s multiple comparisons test was conducted. *,	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Two-way", "ANOVA", "followed", "by", "Dunnett", "’s", "multiple", "comparis...
PMC11707577	Spheroids were then washed thrice with PBS 1x, to remove unbound targeting agents, and stained for 15 min with Hoecsht 33342.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Spheroi...
PMC10818573	Farage, CCRF-SB, and MC/CAR are listed as EBV transformants in the NCBI database.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Farage", ",", "CCRF-SB", ",", "and", "MC/CAR", "are", ...
PMC9221284	The cell pellets were washed with PBS (phosphate-buffered saline) twice and then used for either RNA or protein extraction.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cell", "pe...
PMC11593713	It can cause more severe disease, especially in people with weakened immune systems.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "can", "cause", "more", "severe", "disease", ",", "especial...
PMC10538569	The iDCs were prepared as previously described (37).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "iDCs", "were", "prepared", "as", "previously", "described", "(", "37", ")", "." ...
PMC11025866	An approach to separate the HDACi function and teratogenicity from the anti-convulsant activity of VPA became available with the discovery of valpromide (VPM; Fig 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11564322	Similarly, the co-treatment with the c-SRC inhibitor I and the VGVAPG or VVGPGA peptides increased the NFKB2 mRNA expression in the MEG-A2 cell line by 94.10 and 93.30%, respectively, compared to the control (Fig. 3C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", ...
PMC11545737	Caspase-3 acts on GSDME causing its cleavage .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Caspase-3", "acts", "on", "GSDME", "causing", "its", "cleavage", "." ] } ]
PMC9429973	Aims: To assess the effectiveness of frontline AZA in treatment-naive adult patients with HR MDS in a real-world setting.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ":", "To", "ass...
PMC11188874	Mechanistic studies revealed that upon HDAC6 inhibition or genetic ablation, the Ub-like (UBL) protein HR23B which interacts with the HDAC6 C-terminal ubiquitin-binding (BUZ) domain, is released and associates with proteasomes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11502066	The global incidence of cancer has increased each year and will be increasing further.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "global", "incidence", "of", "cancer", "has", "increased", ...
PMC11739484	The GAPDH served as an internal control for normalization purposes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "GAPDH", "served", "as", "an", "internal", "control", "for", "normalization", "purposes", ...
PMC11682525	The amplification conditions were as follows: an initial denaturation at 95 °C for 15 minutes, followed by 40 cycles of denaturation at 95 °C for 20 seconds, and annealing/extension at 60 °C for 60 seconds.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10490530	Also, in the A2780 cell overexpressing p53, a higher binding of p53 on the PIK3CA promoter than the baseline A2780 cell was observed.	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "...
PMC7022782	Dulbecco’s Modified Eagle Medium (DMEM with 4.5 g/L glucose, l-glutamine, and sodium pyruvate) was purchased from Corning (Mediatech Inc. A Corning Subsidiary Manassas, Manassas, VA, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11715644	On surfaces with a gradient of stiffness, epithelial monolayers develop emergent durotaxis through force propagation across cell–cell junctions and seamlessly migrate from soft to stiff regions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11366496	Nevertheless, the involvement of RNF122, particularly in glioma, remains unreported in the literature.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Nevertheless", ",", "the", "involvement", "of", "RNF12...
PMC10079526	In brief, maximum projections were generated from z-stack images, nuclear areas were selected based on Hoechst staining.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "brief", ",", "maximum", ...
PMC9874064	∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001 (ordinary one-way ANOVA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "∗p", "", "<", "0.05", ","...
PMC9681981	The membrane pores (diameter >2 nm) on the surface of mammalian cells facilitate the rapid passage of molecules with less diameter of 1 nm, resulting in the decreased level of intracellular potassium ions and increased levels of intracellular sodium and chlorine ions, associated with membrane permeability disruption (Petit et al., 2003 ▶).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11706776	4Effect of KCNN1 knockdown on ES cell proliferation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "4Effect", "of", "KCNN1", "knockdown", "on", "ES", "cell", "proliferation", "." ] } ]
PMC6102174	Swertia punicea (Zihong Zhangyacai), the congener species of S. mileensis, are used for the treatment of hepatitis in the folk of Yunnan Province.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9118379	The dbSAP database combines sequence variant annotations from public databases such as dbSNP, COSMIC, UniProt, HPMD, MS-CanProVar, and Ensembl.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11345828	All of the compounds exemplified in Table 2 show less than a 2-fold difference NCI-H929 GI50 relative to 19 or 20, and maintain a good selectivity against K562.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11782508	The highest azurin production was observed after 36 h, coinciding with an A625/A280 ratio of approximately 0.54.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "highest", "azurin", "production", ...
PMC11188874	Phoenix E cells were cotransfected with Flag-HA-PSMD14 (plasmid #22557) and helper plasmid pCL-Eco (RRID: Addgene_12371) using lipofectamine-3000 (Thermo Fisher Scientific, catalog no. L3000008).	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11733919	Our data also agree with previously published results on the effects of activation of the autophagy pathway on ferroptosis induction by degradation of ferritin and increased labile iron pool in fibroblasts and cancer cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4485786	Cytotoxic T cell and natural killer (NK) cell responses against RMS can be generated in vitro, with adoptive transfer as a potentially immunotherapeutic option, yet the antitumor activity of immune effector cells has many more facets.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11779993	The analysis found that the major constituents were flavonoid, phenolic, and carotenoid, with values of 102.13 ± 3.11 mg/g QE, 29.06 ± 0.04 mg/g GAE, and 1.45 ± 0.01 mg/g β-carotene, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11267830	A mixture of equal parts 1.2% agarose gel and medium was added to the bottom of a plate, and a mixture of equal parts 0.7% agarose gel and medium was added as a second layer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9917080	On the one hand, ER stress, which plays a key role in tumor pathogenesis, can lead to tumor progression and resistance to chemoradiotherapy .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC10933092	The current mA sequencing results identified mA modifications around the 5′UTR, the start codon, and CDS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "current", "mA", "sequencing", "...
PMC10873328	TGFBI was knocked down by siRNAs in OC cells, CCK8 and in vitro migration and invasion assays were performed to examine the changes in cell proliferation, motility and metastasis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11291490	Furthermore, this study conducted further investigations into which cell types’ proliferation dusCD40L promoted.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "this", "study", "conducted", "further", ...
PMC11594806	The results revealed that in non-chemoresistant (N-CHR) patients, P2X7 expression levels increased and A2AR expression decreased in CD8+ T cells compared to in chemoresistant (CHR) patients, where P2X7 expression was reduced.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11306331	A Schematic of approach.	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "A", "Schematic", "of", "approach", "." ] } ]
PMC11543885	Active interaction sources, including text mining, experiments, and databases, and an interaction score > 0.7 (high confidence interaction) are applied to construct the PPI networks.d.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10178190	Moreover, 2HE2 is a prodrug of 2ME2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "2HE2", "is", "a", "prodrug", "of", "2ME2", "." ] } ]
PMC9429973	The clearance rate might be smoother in group2 than that in group1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "clearance", "rate", "might", "be", "smoother", "in", "group2", "than", ...
PMC9429973	BTK-targeted therapy has been shown to be safe and effective in a variety of B-cell lymphomas, including chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma (SLL), mantle cell lymphoma (MCL), marginal zone lymphoma (MZL), and Waldenström macroglobulinemia (WM).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11788920	After the treatment, the cells were incubated for 24 h. The total RNA from transfected Ramos cells was extracted using the Trizol reagent following a previously optimized protocol.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11599565	Of note, cells with (also partial) EMT-MET phenotypes like cancer stem cells (CSCs) quickly adapt to changing environments because they are intrinsically refractory to chemo or radiation-based treatments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11519567	B Representative images of EGFP, SS18-EGFP and SS18-SSX1-EGFP fusion protein overexpressed via lentiviral infection in BJ fibroblasts.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "B", "Representative", "images", "of", ...
PMC8753818	It has been suggested that caspase-3 is the major mediator of apoptosis, while caspase-7 plays other roles .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "has", "been", "suggested", "that...
PMC4485786	Filled squares indicate expression of up to 12 fragments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Filled", "squares", "indicate", "expression", "of", "up", "to", "12", "fragments", "." ] } ]
PMC11791478	The concentrations of intact 25A3–vedotin (25A3 conjugated with at least one vedotin molecule) were determined by a similar method, except that a biotinylated anti-vedotin antibody was employed as the capture reagent.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Older patients had higher Cmin, particularly prior to dose adjustments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Older", "patients", "had", "higher", "Cmin", ",", "particularly", "prior", "to", "dos...
PMC9429973	Real-life SOC treatments were defined as those used in local clinical practice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Real-life", "SOC", "treatments", "were", "defined", "as", "those", "used", "in",...
PMC11745823	This study utilised the semiquantitative scoring technique immunoreactive score (IRS), which is calculated by multiplying the staining intensity (SI) by the percentage of positive cells (PP%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11740907	The charge, stability, and dispersion capacity of P5W30-BW-SLNs were evaluated using the measurement of the zeta potential, that served as an indication of their stability.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11244823	Once these conditions and parameters were established, it was possible to stratify the results against anamnestic data.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Once", "these", "conditions", "and", "...
PMC9429973	Broviac was placed in both allogenic (53%) and autologous (47%) HSCT.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Broviac", "was", "placed", "in", "both", "a...
PMC11781181	Targeting ferroptosis in keratinocyte may be a therapeutic strategy for preventing SJS/TEN in the future.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Targeting", "ferroptosis", "in", "keratinocyte", "may", "be", ...
PMC11621493	One well of a 6-well plate was transfected according to the following protocol: 125 μl Opti-MEM I Reduced Serum Medium (31985062, Gibco) premixed with 3.75 μl Lipofectamine 3000 was pooled with 125 μl Opti-MEM Reduced Serum Medium containing 2.5 μg plasmid and 5 μl p3000 reagent.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8662250	Moreover, following the SP challenge in vitro, we further detected a huge ablation of RhoA GTPase and the subsequent significative loss of epithelial integrity, highlighted by the progressive reduction of TEER scores and also featured by tight junction proteins ZO‐1 and occludin decrease.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	However, validation of our predictive model through prospective study with a larger number of patients are required.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "validation", "of", "ou...
PMC10376064	After adding a 2.4 mL homogenization buffer to each dish, the cells were scratched from the bottom and transferred into 50 mL reaction tubes (VWR) on ice, subsequently repeating this step.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11342785	Scale bars represent 20 μm.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bars", "represent", "20", "μm", "." ] } ]
PMC11737091	After DBF4 was knocked down with pLKO.1-DBF4-shRNA, 2,000 786-O or A498 RCC cells were seeded in 96-well plates and cultured in complete medium for 3 days.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC9429973	Informed consent was waived.	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "Informed", "consent", "was", "waived", "." ] } ]
PMC7612475	B, Schematic representation of replication fork labeling assay.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "B", ",", "Schematic", "representation", "of", "replication", "fork", "labeling", "assay", "." ] } ]
PMC9516447	Recently, we discovered that haploinsufficiency of a single cellular protein, GRP78, while having no harmful effect on the normal pancreas, is sufficient to suppress acinar-to-ductal metaplasia, ERK and AKT signaling and impede KRAS driven pancreatic tumorigenesis .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11697703	MAPK8 phosphorylates a wide range of nuclear and cytosolic substrates.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MAPK8", "phosphorylates", "a", "wide", "range", "of", "nuclear", "and", "cytosolic", "substrates...
PMC11225860	While restricted to specialized cell types in normal human tissues, polyploidy has been associated with almost all solid and liquid cancers .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "While", "res...
PMC11742864	Increasing researches also showed that supplementation with ω-3 LCPUFAs benefited the therapeutical prognosis of patients with lung cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Increasing", "researches", "also", "showed",...
PMC9275501	The EPR effect was used to effectively target breast tumors, thereby promoting their cellular uptake and tumor deep penetration, and triggering the rapid release of PTX and CUR.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11739484	In order to gain deeper insights into the role and potential mechanisms underlying MMP7, MMP11, and MMP14 expression in SKCM, we examined their functional status in the CancerSEA database.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9927933	Consistently, ectopic overexpression of CDH1 shortened the protein half-life of WT as well as the MT1 and MT2 DEPTOR mutants, but had no effect on the MT3 mutant (Figure 5F and Supplemental Figure 5G).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	BEM+LDAC warrants further evaluation in this population.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "BEM+LDAC", "warrants", "further", "evaluation", "in", "this", "population", "." ] } ]
PMC11155445	Complex (62d) had a scavenging ability of up to 86.19%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Complex", "(", "62d", ")", "had", "a", "scavenging", "ability", "of",...
PMC10125312	The higher uptake by cells was in agreement with a decrease of cellular viability when studied with the MTT assay, the gold standard assay for cytotoxicity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11742290	Overexpression of LGR5 increased cell proliferationColorectalColon cancer cell lines: LOVO, HT29, HCT116 LGR5 silencing reduced proliferation, migration and colony formation, and downregulated NOTCH signaling in vitro and tumorigenicity in vivoColorectalCRC cell lines: HT-29, SW480, LGR5 expression correlated with proliferation via the WNT/β-catenin pathway in CRC tissuesColorectalCRC tissues (n = 53) Ablation of LGR5 enhanced cell growth, tumorigenesis and clonogenicityColorectalColon cancer cell line: LIM1899 LGR5-KD decreased APC (adenomatous polyposis coli) expression and WNT/β-catenin pathway and inhibited cell proliferation in HT29 cellsColorectalColon cancer cell line: HT29 Depleting LGR5 inhibited proliferation via suppressing WNT signaling in CRC cells Depleting LGR5 induced apoptosis, suppressed β-catenin nuclear translocation and blocked the activity of Wnt/β-catenin signalingColorectalColon cancer cell lines: LOVO, HT-29, and SW48 LGR5 silencing inhibited cell proliferation, secondary tumor sphere formation and induced cell apoptosis, and G0/G1 phase in vitro LGR5-KD suppressed tumorigenicity of HT29 spheroid cells in vivoColorectalColon cancer cell line: HT-29BALB/C-nu mice High LGR5 protein and mRNA expression positively correlated with cell proliferation in vitro and in vivoColorectalColon cancer patient tissues (n = 366).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11628904	All image processing and analysis were performed using FIJI 2.9.0.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "image", "processing", "and", "analysis", "were", "performed", "using", "FIJI", "2.9.0", ...
PMC11773391	Although MGMT level was not high in MM cells with chemotherapy, the transcriptional activity of MGMT could be improved by activation of the ERK signalling pathway after TMZ treatment, which may be one of the mechanisms of resistance to TMZ malignant tumour.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9621239	This study revealed that the mutation spectrum of the genotype C X gene clones was different from that of genotype B X gene clones, and the mutations in genotype C X gene clones were mainly clustered in the dimerization region and the aa110 to aa140 sites within the transcriptional activation region of HBx protein, which changes the function of HBx protein.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5839394	In particular, we found that AgNPs-EPS caused: i) a significant decrease of cell viability and motility, ii) an impairment of MMP-2 and MMP-9 activity, and iii) a promotion of ROS generation, which, in turn, induced cell death through apoptosis and autophagy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC3019555	Understanding these pathways may help elucidate mechanisms of resistance to MTDs and provide important insights into the selection of tumor types and/or individual patients most likely to benefit from this class of chemotherapeutics.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8143558	The leaves, which are relatively softer compared to the other studied parts, showed a rising change from aqueous to ethanol solvents.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC9429973	While classical method for personal PK needs multiple blood collections, at least 5 points collections for children and 11points for adults, and expensive for testing and leads low compliance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10606998	For further experiments with cell irradiation, a particle concentration of 100 µg/mL was chosen.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "further", "experiments", "with", "cell", "irradiation", ...
PMC11092418	We examined the growth response of HBCCLs to treatment with 17 targeted agents compared to two cytotoxic drugs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "examined", "the", "growth", "res...
PMC11352311	During apoptosis, the BAX/Bcl2 ratio increases.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "During", "apoptosis", ",", "the", "BAX/Bcl2", "ratio", "increases", "." ] } ]
PMC7136814	GSK126 is a selective inhibitor of EZH2, a histone methyltransferase that epigenetically suppresses the transcription of myogenic genes .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "GSK126", "is", "a", "selective", ...
PMC11747885	This suggests that the inhibitor may act through competitive binding with the RNA substrate or by the induction of an allosteric effect.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "sugg...
PMC9429973	Additionally, The LAU ratio had an area under receiver operating characteristic (ROC) of 0.67 (95% confidence interval 0.56 to 0.79) compared to 0.60 (95% confidence interval 0.54 to 0.68) using NLR.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10421378	One such mechanism involves lectin–carbohydrate interactions, in which lectins, which are carbohydrate-binding proteins found on the surface of probiotic cells, recognize specific carbohydrates on the epithelial cell surface, thereby facilitating adhesion.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11013014	HRMS (+ESI) m/z: [M + H] calculated for C21H20Cl2N3O3: 432.0876, found, 432.0873.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HRMS", "(", "+", ...
PMC11748618	While rs73004025-C-T overlaps with altered H3K9ac in primary CD8 + T cells and chromatin states in K562 cells, as determined by haploR in ENCODE data; this variant is not an eQTL in GTEx, AGFR, or MESA and is not an meQTL in ENCODE.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11758416	Note: We used Dynabeads (Thermo Fisher Scientific) at a 5:1 (cell to bead) ratio to stimulate T cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Note", ...
PMC11535726	Kirschsteiniotheliadendryphioides (HKAS 136930, holotype) a, b colonies on natural substrate c, d conidiophores, conidiogenous cells bearing conidia e–g conidiogenous cells bearing conidia h–o conidia p upper surface view of culture q lower surface view of culture; Scale bars: 100 μm (c, d); 50 μm (e); 20 μm (f–o).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Within 6 m., 6 p. had perm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Within", "6", "m.", ",", "6", "p.", "had", "perm", "." ] } ]
PMC11746942	Nuclei were counterstained with DAPI (blue).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Nuclei", "were", "counterstained", "with", "DAPI", "(", "blue", ")", "." ] } ]
PMC6450504	p < .0001 (b) The survival curve of tumor-bearing animals.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "p", "<", ".0001", "(", "b", ")", "The", "survival", "curve", "of", "...
PMC11781181	However, the initiation of this process is hindered by various factors, including difficulties in obtaining ethical consent from patients, challenges in excising skin lesions from patients who have recovered from SJS/TEN, the ambiguity of causative drugs, and the intricacies of replicating human SJS/TEN progression in vivo.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11045125	Given the previously described ability of NF-κB signaling to inhibit the formation and survival of EBV-negative Myc-induced BLs , inhibition of LMP1-induced NF-κB activity may likewise be essential for the development of EBV+ human BLs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

All CRS cases were rapidly relieved after conventional CRS intervention, including tocilizumab and steroids.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "CRS", "cases", "were", "rapidly", "relieved", "after...

PMC10729469

The X-ray tube was used at 150 μA and 75 kV. Each run obtained 512 projections with an exposure time of 230 ms.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...

PMC9577200

This work was funded by County Council of Västerbotten (BS), Cancer Research Foundation in Northern Sweden, Lion's Cancer Research Foundation in Northern Sweden (BS), and Kempestiftelserna (BS).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11615828

With this tool, we monitored the acute effects of IFT immobilization on cilia structure in real time.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "With", "this", "tool", ",", "we", ...

PMC11657744

Two-way ANOVA followed by Dunnett’s multiple comparisons test was conducted. *,

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Two-way", "ANOVA", "followed", "by", "Dunnett", "’s", "multiple", "comparis...

PMC11707577

Spheroids were then washed thrice with PBS 1x, to remove unbound targeting agents, and stained for 15 min with Hoecsht 33342.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Spheroi...

PMC10818573

Farage, CCRF-SB, and MC/CAR are listed as EBV transformants in the NCBI database.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Farage", ",", "CCRF-SB", ",", "and", "MC/CAR", "are", ...

PMC9221284

The cell pellets were washed with PBS (phosphate-buffered saline) twice and then used for either RNA or protein extraction.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cell", "pe...

PMC11593713

It can cause more severe disease, especially in people with weakened immune systems.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "can", "cause", "more", "severe", "disease", ",", "especial...

PMC10538569

The iDCs were prepared as previously described (37).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "iDCs", "were", "prepared", "as", "previously", "described", "(", "37", ")", "." ...

PMC11025866

An approach to separate the HDACi function and teratogenicity from the anti-convulsant activity of VPA became available with the discovery of valpromide (VPM; Fig 1).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11564322

Similarly, the co-treatment with the c-SRC inhibitor I and the VGVAPG or VVGPGA peptides increased the NFKB2 mRNA expression in the MEG-A2 cell line by 94.10 and 93.30%, respectively, compared to the control (Fig. 3C).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", ...

PMC11545737

Caspase-3 acts on GSDME causing its cleavage .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Caspase-3", "acts", "on", "GSDME", "causing", "its", "cleavage", "." ] } ]

PMC9429973

Aims: To assess the effectiveness of frontline AZA in treatment-naive adult patients with HR MDS in a real-world setting.

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PMC11188874

Mechanistic studies revealed that upon HDAC6 inhibition or genetic ablation, the Ub-like (UBL) protein HR23B which interacts with the HDAC6 C-terminal ubiquitin-binding (BUZ) domain, is released and associates with proteasomes.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11502066

The global incidence of cancer has increased each year and will be increasing further.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "global", "incidence", "of", "cancer", "has", "increased", ...

PMC11739484

The GAPDH served as an internal control for normalization purposes.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "GAPDH", "served", "as", "an", "internal", "control", "for", "normalization", "purposes", ...

PMC11682525

The amplification conditions were as follows: an initial denaturation at 95 °C for 15 minutes, followed by 40 cycles of denaturation at 95 °C for 20 seconds, and annealing/extension at 60 °C for 60 seconds.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10490530

Also, in the A2780 cell overexpressing p53, a higher binding of p53 on the PIK3CA promoter than the baseline A2780 cell was observed.

[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "...

PMC7022782

Dulbecco’s Modified Eagle Medium (DMEM with 4.5 g/L glucose, l-glutamine, and sodium pyruvate) was purchased from Corning (Mediatech Inc. A Corning Subsidiary Manassas, Manassas, VA, USA).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11715644

On surfaces with a gradient of stiffness, epithelial monolayers develop emergent durotaxis through force propagation across cell–cell junctions and seamlessly migrate from soft to stiff regions.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11366496

Nevertheless, the involvement of RNF122, particularly in glioma, remains unreported in the literature.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Nevertheless", ",", "the", "involvement", "of", "RNF12...

PMC10079526

In brief, maximum projections were generated from z-stack images, nuclear areas were selected based on Hoechst staining.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "brief", ",", "maximum", ...

PMC9874064

∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001 (ordinary one-way ANOVA).

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PMC9681981

The membrane pores (diameter >2 nm) on the surface of mammalian cells facilitate the rapid passage of molecules with less diameter of 1 nm, resulting in the decreased level of intracellular potassium ions and increased levels of intracellular sodium and chlorine ions, associated with membrane permeability disruption (Petit et al., 2003 ▶).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11706776

4Effect of KCNN1 knockdown on ES cell proliferation.

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PMC6102174

Swertia punicea (Zihong Zhangyacai), the congener species of S. mileensis, are used for the treatment of hepatitis in the folk of Yunnan Province.

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PMC9118379

The dbSAP database combines sequence variant annotations from public databases such as dbSNP, COSMIC, UniProt, HPMD, MS-CanProVar, and Ensembl.

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PMC11345828

All of the compounds exemplified in Table 2 show less than a 2-fold difference NCI-H929 GI50 relative to 19 or 20, and maintain a good selectivity against K562.

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PMC11782508

The highest azurin production was observed after 36 h, coinciding with an A625/A280 ratio of approximately 0.54.

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PMC11188874

Phoenix E cells were cotransfected with Flag-HA-PSMD14 (plasmid #22557) and helper plasmid pCL-Eco (RRID: Addgene_12371) using lipofectamine-3000 (Thermo Fisher Scientific, catalog no. L3000008).

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PMC11733919

Our data also agree with previously published results on the effects of activation of the autophagy pathway on ferroptosis induction by degradation of ferritin and increased labile iron pool in fibroblasts and cancer cells.

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PMC4485786

Cytotoxic T cell and natural killer (NK) cell responses against RMS can be generated in vitro, with adoptive transfer as a potentially immunotherapeutic option, yet the antitumor activity of immune effector cells has many more facets.

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PMC11779993

The analysis found that the major constituents were flavonoid, phenolic, and carotenoid, with values of 102.13 ± 3.11 mg/g QE, 29.06 ± 0.04 mg/g GAE, and 1.45 ± 0.01 mg/g β-carotene, respectively.

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PMC11267830

A mixture of equal parts 1.2% agarose gel and medium was added to the bottom of a plate, and a mixture of equal parts 0.7% agarose gel and medium was added as a second layer.

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PMC9917080

On the one hand, ER stress, which plays a key role in tumor pathogenesis, can lead to tumor progression and resistance to chemoradiotherapy .

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PMC10933092

The current mA sequencing results identified mA modifications around the 5′UTR, the start codon, and CDS.

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PMC10873328

TGFBI was knocked down by siRNAs in OC cells, CCK8 and in vitro migration and invasion assays were performed to examine the changes in cell proliferation, motility and metastasis.

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PMC11291490

Furthermore, this study conducted further investigations into which cell types’ proliferation dusCD40L promoted.

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PMC11594806

The results revealed that in non-chemoresistant (N-CHR) patients, P2X7 expression levels increased and A2AR expression decreased in CD8+ T cells compared to in chemoresistant (CHR) patients, where P2X7 expression was reduced.

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PMC11306331

A Schematic of approach.

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PMC11543885

Active interaction sources, including text mining, experiments, and databases, and an interaction score > 0.7 (high confidence interaction) are applied to construct the PPI networks.d.

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PMC10178190

Moreover, 2HE2 is a prodrug of 2ME2.

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PMC9429973

The clearance rate might be smoother in group2 than that in group1.

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PMC9429973

BTK-targeted therapy has been shown to be safe and effective in a variety of B-cell lymphomas, including chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma (SLL), mantle cell lymphoma (MCL), marginal zone lymphoma (MZL), and Waldenström macroglobulinemia (WM).

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PMC11788920

After the treatment, the cells were incubated for 24 h. The total RNA from transfected Ramos cells was extracted using the Trizol reagent following a previously optimized protocol.

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PMC11599565

Of note, cells with (also partial) EMT-MET phenotypes like cancer stem cells (CSCs) quickly adapt to changing environments because they are intrinsically refractory to chemo or radiation-based treatments.

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PMC11519567

B Representative images of EGFP, SS18-EGFP and SS18-SSX1-EGFP fusion protein overexpressed via lentiviral infection in BJ fibroblasts.

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PMC8753818

It has been suggested that caspase-3 is the major mediator of apoptosis, while caspase-7 plays other roles .

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PMC4485786

Filled squares indicate expression of up to 12 fragments.

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PMC11791478

The concentrations of intact 25A3–vedotin (25A3 conjugated with at least one vedotin molecule) were determined by a similar method, except that a biotinylated anti-vedotin antibody was employed as the capture reagent.

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PMC9429973

Older patients had higher Cmin, particularly prior to dose adjustments.

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PMC9429973

Real-life SOC treatments were defined as those used in local clinical practice.

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PMC11745823

This study utilised the semiquantitative scoring technique immunoreactive score (IRS), which is calculated by multiplying the staining intensity (SI) by the percentage of positive cells (PP%).

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PMC11740907

The charge, stability, and dispersion capacity of P5W30-BW-SLNs were evaluated using the measurement of the zeta potential, that served as an indication of their stability.

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PMC11244823

Once these conditions and parameters were established, it was possible to stratify the results against anamnestic data.

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PMC9429973

Broviac was placed in both allogenic (53%) and autologous (47%) HSCT.

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PMC11781181

Targeting ferroptosis in keratinocyte may be a therapeutic strategy for preventing SJS/TEN in the future.

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PMC11621493

One well of a 6-well plate was transfected according to the following protocol: 125 μl Opti-MEM I Reduced Serum Medium (31985062, Gibco) premixed with 3.75 μl Lipofectamine 3000 was pooled with 125 μl Opti-MEM Reduced Serum Medium containing 2.5 μg plasmid and 5 μl p3000 reagent.

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PMC8662250

Moreover, following the SP challenge in vitro, we further detected a huge ablation of RhoA GTPase and the subsequent significative loss of epithelial integrity, highlighted by the progressive reduction of TEER scores and also featured by tight junction proteins ZO‐1 and occludin decrease.

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PMC9429973

However, validation of our predictive model through prospective study with a larger number of patients are required.

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PMC10376064

After adding a 2.4 mL homogenization buffer to each dish, the cells were scratched from the bottom and transferred into 50 mL reaction tubes (VWR) on ice, subsequently repeating this step.

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PMC11342785

Scale bars represent 20 μm.

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PMC11737091

After DBF4 was knocked down with pLKO.1-DBF4-shRNA, 2,000 786-O or A498 RCC cells were seeded in 96-well plates and cultured in complete medium for 3 days.

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PMC9429973

Informed consent was waived.

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PMC7612475

B, Schematic representation of replication fork labeling assay.

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PMC9516447

Recently, we discovered that haploinsufficiency of a single cellular protein, GRP78, while having no harmful effect on the normal pancreas, is sufficient to suppress acinar-to-ductal metaplasia, ERK and AKT signaling and impede KRAS driven pancreatic tumorigenesis .

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PMC11697703

MAPK8 phosphorylates a wide range of nuclear and cytosolic substrates.

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PMC11225860

While restricted to specialized cell types in normal human tissues, polyploidy has been associated with almost all solid and liquid cancers .

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PMC11742864

Increasing researches also showed that supplementation with ω-3 LCPUFAs benefited the therapeutical prognosis of patients with lung cancer.

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PMC9275501

The EPR effect was used to effectively target breast tumors, thereby promoting their cellular uptake and tumor deep penetration, and triggering the rapid release of PTX and CUR.

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PMC11739484

In order to gain deeper insights into the role and potential mechanisms underlying MMP7, MMP11, and MMP14 expression in SKCM, we examined their functional status in the CancerSEA database.

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PMC9927933

Consistently, ectopic overexpression of CDH1 shortened the protein half-life of WT as well as the MT1 and MT2 DEPTOR mutants, but had no effect on the MT3 mutant (Figure 5F and Supplemental Figure 5G).

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PMC9429973

BEM+LDAC warrants further evaluation in this population.

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PMC11155445

Complex (62d) had a scavenging ability of up to 86.19%.

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PMC10125312

The higher uptake by cells was in agreement with a decrease of cellular viability when studied with the MTT assay, the gold standard assay for cytotoxicity.

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PMC11742290

Overexpression of LGR5 increased cell proliferationColorectalColon cancer cell lines: LOVO, HT29, HCT116 LGR5 silencing reduced proliferation, migration and colony formation, and downregulated NOTCH signaling in vitro and tumorigenicity in vivoColorectalCRC cell lines: HT-29, SW480, LGR5 expression correlated with proliferation via the WNT/β-catenin pathway in CRC tissuesColorectalCRC tissues (n = 53) Ablation of LGR5 enhanced cell growth, tumorigenesis and clonogenicityColorectalColon cancer cell line: LIM1899 LGR5-KD decreased APC (adenomatous polyposis coli) expression and WNT/β-catenin pathway and inhibited cell proliferation in HT29 cellsColorectalColon cancer cell line: HT29 Depleting LGR5 inhibited proliferation via suppressing WNT signaling in CRC cells Depleting LGR5 induced apoptosis, suppressed β-catenin nuclear translocation and blocked the activity of Wnt/β-catenin signalingColorectalColon cancer cell lines: LOVO, HT-29, and SW48 LGR5 silencing inhibited cell proliferation, secondary tumor sphere formation and induced cell apoptosis, and G0/G1 phase in vitro LGR5-KD suppressed tumorigenicity of HT29 spheroid cells in vivoColorectalColon cancer cell line: HT-29BALB/C-nu mice High LGR5 protein and mRNA expression positively correlated with cell proliferation in vitro and in vivoColorectalColon cancer patient tissues (n = 366).

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PMC11628904

All image processing and analysis were performed using FIJI 2.9.0.

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PMC11773391

Although MGMT level was not high in MM cells with chemotherapy, the transcriptional activity of MGMT could be improved by activation of the ERK signalling pathway after TMZ treatment, which may be one of the mechanisms of resistance to TMZ malignant tumour.

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PMC9621239

This study revealed that the mutation spectrum of the genotype C X gene clones was different from that of genotype B X gene clones, and the mutations in genotype C X gene clones were mainly clustered in the dimerization region and the aa110 to aa140 sites within the transcriptional activation region of HBx protein, which changes the function of HBx protein.

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PMC5839394

In particular, we found that AgNPs-EPS caused: i) a significant decrease of cell viability and motility, ii) an impairment of MMP-2 and MMP-9 activity, and iii) a promotion of ROS generation, which, in turn, induced cell death through apoptosis and autophagy.

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PMC3019555

Understanding these pathways may help elucidate mechanisms of resistance to MTDs and provide important insights into the selection of tumor types and/or individual patients most likely to benefit from this class of chemotherapeutics.

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PMC8143558

The leaves, which are relatively softer compared to the other studied parts, showed a rising change from aqueous to ethanol solvents.

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PMC9429973

While classical method for personal PK needs multiple blood collections, at least 5 points collections for children and 11points for adults, and expensive for testing and leads low compliance.

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PMC10606998

For further experiments with cell irradiation, a particle concentration of 100 µg/mL was chosen.

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PMC11092418

We examined the growth response of HBCCLs to treatment with 17 targeted agents compared to two cytotoxic drugs.

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PMC11352311

During apoptosis, the BAX/Bcl2 ratio increases.

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PMC7136814

GSK126 is a selective inhibitor of EZH2, a histone methyltransferase that epigenetically suppresses the transcription of myogenic genes .

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PMC11747885

This suggests that the inhibitor may act through competitive binding with the RNA substrate or by the induction of an allosteric effect.

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PMC9429973

Additionally, The LAU ratio had an area under receiver operating characteristic (ROC) of 0.67 (95% confidence interval 0.56 to 0.79) compared to 0.60 (95% confidence interval 0.54 to 0.68) using NLR.

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PMC10421378

One such mechanism involves lectin–carbohydrate interactions, in which lectins, which are carbohydrate-binding proteins found on the surface of probiotic cells, recognize specific carbohydrates on the epithelial cell surface, thereby facilitating adhesion.

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PMC11013014

HRMS (+ESI) m/z: [M + H] calculated for C21H20Cl2N3O3: 432.0876, found, 432.0873.

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PMC11748618

While rs73004025-C-T overlaps with altered H3K9ac in primary CD8 + T cells and chromatin states in K562 cells, as determined by haploR in ENCODE data; this variant is not an eQTL in GTEx, AGFR, or MESA and is not an meQTL in ENCODE.

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PMC11758416

Note: We used Dynabeads (Thermo Fisher Scientific) at a 5:1 (cell to bead) ratio to stimulate T cells.

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PMC11535726

Kirschsteiniotheliadendryphioides (HKAS 136930, holotype) a, b colonies on natural substrate c, d conidiophores, conidiogenous cells bearing conidia e–g conidiogenous cells bearing conidia h–o conidia p upper surface view of culture q lower surface view of culture; Scale bars: 100 μm (c, d); 50 μm (e); 20 μm (f–o).

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PMC9429973

Within 6 m., 6 p. had perm.

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PMC11746942

Nuclei were counterstained with DAPI (blue).

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PMC6450504

p < .0001 (b) The survival curve of tumor-bearing animals.

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PMC11781181

However, the initiation of this process is hindered by various factors, including difficulties in obtaining ethical consent from patients, challenges in excising skin lesions from patients who have recovered from SJS/TEN, the ambiguity of causative drugs, and the intricacies of replicating human SJS/TEN progression in vivo.

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PMC11045125

Given the previously described ability of NF-κB signaling to inhibit the formation and survival of EBV-negative Myc-induced BLs , inhibition of LMP1-induced NF-κB activity may likewise be essential for the development of EBV+ human BLs.

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