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PMC11746942
B Representative immunofluorescence images of K17 (red) and P-STAT3 (green) in psoriasis-like lesions from WT and S1PR3-KO mice with and without IMQ treatment.
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PMC11768281
CD8+ T cells differentiate into several subsets with specialized roles in immunity.
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PMC11574271
A detailed analysis of putative miRNAs in interacting with RON using software programs including TargetScan, MiRDB, Mirmap, and Diana Tools led to several predictions that miRNAs such as miR-269-5p, miR-659-3p, miR-4432-5p, miR-4436b-3p, and miR-6721-5p might be able to interact with RON specifically (Fig. 5A).
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PMC9351137
As shown in Fig. 6B, C and Table 3, the results of three independent replicates showed that the midbody localization pattern of the cytokinesis regulators under investigation was impaired in BAF53a and Tip60 depleted HeLa cells.
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PMC10748106
Furthermore, we performed a SAR analysis incorporating 13 iridoids with a high structural similarity to Geniposide and Genipin, also tested in the HeLa cell line and at the same treatment time.
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PMC11779605
The use of serum as a surrogate for the tumor offers a less-invasive opportunity to detect and monitor biomarkers of prognosis, treatment response, and recurrence.
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PMC11200978
Samples were gated to exclude cellular debris.
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PMC11766309
Tests for mycoplasma contamination were performed routinely.
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PMC11588008
Figure 1a).
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PMC11761919
The sections were stained with hematoxylin and eosin (HE), and the histopathological changes were observed.
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PMC7452526
Figure 2 a) SEM image and b) EDX spectrum of silver nanoparticles prepared using aqueous extract of Eucalyptus Camaldulensis leaves.
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PMC11774251
Normal keratinocyte differentiation is crucial for maintaining skin barrier function, while abnormal proliferation and differentiation of keratinocytes are considered core pathological features of psoriasis.
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PMC10507284
We observed that TROAP was upregulated in most types of tumor tissues (Figure S1A).
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PMC11782780
A p<0.05 was deemed statistically significant.
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PMC11453690
There was no difference in proliferation patterns between treatment groups.
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PMC11682172
For abbreviated cell lines see M&M. BBB passage following co-culture with T cells or T cell medium.
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PMC11467964
Furthermore, immune infiltration levels of 22 human cells were evaluated through CIBERSORT algorithm.
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PMC11502066
In addition, GPCR ligands are often overproduced during oncogenesis, in turn inducing excessive activation of their receptors and stimulating oncogenic signaling networks .
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PMC11705547
Consistent with this, IL-34 inhibitors can reverse cisplatin resistance and improve anti-tumor efficacy by inhibiting the M2-like TAMs .
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PMC9512971
For the primary endpoint, the time to SARS-CoV-2 negativity (in days) was calculated as the date of the first (of two consecutive) SARS-CoV-2 negativity test minus the date of randomization plus one.
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PMC11695546
In accordance with a previous report by Al-Rajhi and Abdel Ghany (2023) that showed treatment of oils with ozone enhance its anticancer impact.
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PMC11640476
The mean relative expanded uncertainty (U%) for resazurin assay on the A549 cell line was found to be optimal, measuring at 14.2% (20.3% for Blank, 16.9% for low, 11.6% for medium, and 8.1% for high confluency).
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PMC11659734
For this project, we selected the comet assay and the micronucleus assay to evaluate in vitro the genotoxicity of BPA alternatives, BPE and BPP.
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PMC9119314
In an acute oral toxicity test in mice, 3–6 did not exhibit toxic effects at doses of up to 100 mg/kg/dose × 3 consecutive days.
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PMC11621493
Pla2g4d mRNA expression normalized to 36b4 HK gene in primary keratinocytes and the human HaCaT keratinocyte cell line (n = 3).
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PMC10938336
In addition, both compounds 2 and 4 induced apoptosis in HL-60 cells.
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PMC8348645
A MTT assay was performed to investigate the viability of the extracts of HepG2 cells, and the mode of cell death was detected by Ao/EtBr staining and flow cytometry with PI Annexin- V FITC dual staining.
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PMC9429973
The median age was 36 years (range, 18-75).
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PMC5874706
The precipitate was then dried overnight and the resulting powder containing the loaded nanoparticles was dissolved in ethanol to obtain a clear solution, the absorbance of which was analyzed using a spectrophotometer at a wavelength of 460 nm for the calculation of the encapsulated drug quantity.
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PMC10823017
However, drug treatment with single or combination treatment did not cause any significant change in the total-Akt level ( Figures 5A, C ).
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PMC10919056
The objective of this study was to screen out GJPs related prognostic signatures (GRPS) associated with clear cell renal cell carcinoma (ccRCC).
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PMC9780037
The therapeutic potential of cyt c under limited refrigeration conditions might be further enhanced through PEGylation and storage in ionic liquid solutions, which enhance its thermal stability.
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PMC9429973
Results: We identified 10 pediatric cases carrying a JAK2 fusion with different partners, where PAX5 gene was the only recurrent.
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PMC11412721
Right, comparison of the ACKR4 proteins encoded by WT alleles from BL Raji control cells (center), or by the 4.14a (top) and 4.14b mutated alleles (bottom).
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PMC6643347
NMR spectroscopy was performed using a Bruker Avance 400 MHz NMR spectrometer.
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PMC11743316
The major miRNA in ovarian carcinoma, miR-450a, restricts the spreading capacity of ovarian cancerous cells through targeting a series of mitochondrial mRNAs to decrease glutaminolysis and glycolysis .
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PMC11629143
Chromatin was extracted using a method adapted from Ghisletti et al. .
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PMC10571053
Piperazine erastin was from TargetMol (Wellesly Hills, MA).
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PMC11766174
The isolated PBMCs were used for CA-ICC, p27 Simoa, and SIV viral RNA measurements.
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PMC9429973
After the median follow-up time of 4.5 months (range 0.7-8.6), the median OS was not reached.
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PMC11271278
We identified ETV1 (chromosome 7) as a trans-enhancer hijacking gene in both LNCaP and MDAPCA2B cells, with most of its trans-enhancer activity coming from chromosome 14 (Fig. 3A).
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PMC9429973
In all parts, treatment may discontinue due to relapse/unacceptable toxicity, or continue beyond 24 cycles under investigator’s discretion.
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PMC7961460
To investigate the effects of c10orf118 on cell viability, a MTT assay was performed in a 96 well plate.
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PMC9429973
Results: During follow-up 31,199 individuals were hospitalized due to an infection.
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PMC11525028
Scale bar: 100 μm (n = 3).(F) Global protein synthesis of ATF4-OE, ASNS-OE, and Asn (0.1 mM)-treated NAT10-KO 143B (left) and HOS (right) cells.(G and H) Tumor growth (G) and survival (H) of the ATF4-OE, ASNS-OE, and Asn-treated (0.25 mmol/kg every two days by intraperitoneal injection [i.p.])
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PMC9429973
Panobinostat was the first HDAC inhibitor (HDACi) approved by FDA for patients with relapse and refractory multiple myeloma (RRMM) in 2015.
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PMC7039683
The second objective was to use zebrafish periderm enhancers to train a classifier with which to prioritize SNPs in non-coding DNA for their likelihood of disrupting periderm enhancers.
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PMC11756514
The HEK293-Langerin or -the empty vector cells (200,000 cells) were incubated with the GFP-expressing S. aureus strains for 30 min at room temperature.
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PMC6160470
For the calcein accumulation assay, 3 × 10 cells were seeded into 96-well microtiter plates and left to attach.
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PMC9592219
Moreover, the data of 110 normal liver tissue samples were obtained from Genotype Tissue Expression (https://xenabrowser.net/hub/).
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PMC11675244
The presence of tumor heterogeneity and small populations of cells with stem-like properties have been established in the majority of malignancies, although debates about their origins and plasticity continue .
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PMC7171147
b Representative images of tumor-specific CPT1A and stroma-specific COL11A1 staining in matched primary and recurrent ovarian tumors.
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PMC11611077
Since the molecular weight of glycosylated prestin is about 100 kDa , these results suggest that full-length prestin with His-tag was expressed in the developed cell line.
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PMC11350568
Targeted membrane protein degradation (TMPD) offers significant therapeutic potential by enabling the removal of harmful membrane-anchored proteins and facilitating detailed studies of complex biological pathways.
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PMC9429973
In addition, high or very high IPSS-R score was associated with significantly higher circRNA expression than lower scores (p<0.001).
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PMC10745221
While we established that there were no large-scale differences in overall protein arginine methylation, it was difficult to determine whether there were differences in arginine methylation on histones since the whole cell extract contained histones as well as other low-molecular weight cellular proteins.
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PMC9318744
As expected, the ACE2plusC3 cells showed strong and ubiquitous expression for both proteins, which may contribute to the stable virus infectivity between the early and late passages (Figure 3G).
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PMC9895440
200’000 cells were then seeded per well and the plate was centrifuged for 1 min at 500 g. Cells were then incubated for 3 h at 37 °C in the incubator.
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PMC8140214
This method relies on assessing inhibition of adrenaline auto-oxidation to adrenochrome by enzyme SOD in alkaline pH 10.2 at 480 nm.
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PMC11345828
The crude residue was purified by flash column chromatography eluting with either EtOAc/hexanes or MeOH/DCM to afford the desired compound.
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PMC11541241
The necrotrophic phytopathogenic fungus B. cinerea is a widespread plant pathogen and can infect numerous important economic and horticultural crops.
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PMC9429973
Safety will be assessed by monitoring adverse events from informed consent until ≥12 weeks after the last dose of study drug.
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PMC9739791
The Pt(IV) prodrug 13 was stable in the phosphate buffer in the dark for 24 h, while only 1.1% of the complex remained after irradiation with blue light (450 nm, 8 mW/cm, 1 h) in the absence of sodium ascorbate.
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PMC11359735
To determine whether the [H]-palmitate was covalently linked to CSP by an ester linkage, we performed base-hydrolysis of [H]-palmitate-labeled CSP.
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PMC11536589
Fig. 1MGST1-mediated ferroptosis inhibition might contribute to the survival of MRTX1133-treated PDAC cells. (
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PMC11783017
These results confirmed that Cis/Mn/NH@PGP could induce augmented ICD for immune response activation.
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PMC9429973
Magrolimab + bortezomib + dexamethasone may be initiated based on the preliminary safety and efficacy of magrolimab + carfilzomib + dexamethasone, and, if initiated, only requires 1 prior line of therapy.
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PMC11727638
As a control, 2D cultured cells in a flask were used.
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PMC11750165
These observations imply that Notch signaling pathway may be partially impaired by knockdown of PEX1, suggesting a possibility that there might be functional redundancy among transporter-related genes, such as PEX6, VCP and NSP (Shiozawa et al., 2004).
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PMC11648299
Death was included as a competing risk, and age was used as the underlying time scale.
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PMC11549062
Scar bar 20 μm. (
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PMC11381192
Relative mRNA level was quantified using the expression of GAPDH as an internal control through the 2 method.
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PMC11750161
CHO-K1 cells transiently transfected with eLH/CGR-wt and mutants were seeded in 384-well plates (10,000 cells/well) at 24 h post-transfection.
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PMC9964635
A humidified atmosphere was provided for incubation at 37 °C with 5% CO2.
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PMC10734950
In addition, they have proven to be effective drugs in various disease scenarios.
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PMC10719213
Sensitivity analyses (see Materials and methods section) using variant filtering AF = 0.001, 0.002, 0.005, and 0.025 did not reveal any differences between patients and controls.
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PMC11699042
High-quality genomic DNA from A-673, HeLa, and MCF-7 wild-type cells at time points m0 and m6 was sequenced using the Illumina PCR-Free Tagmentation Kit (Illumina, CA, USA).
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PMC11721064
Paired box 6 (PAX6) is a crucial transcription factor for developmental regulation of cornea , which governs corneal epithelial cell fate determination .
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PMC11394386
We observed a specific reduction in PI3K pathway activation in the SiHa cell line, but not in the HeLa cell line (Supplementary Figure S1C,D).
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PMC11732628
miR-490-3p, micro RNA-490-3p; TUNEL, transferase dUTP nick end labelling; NC, negative control; DAPI, 4’,6-diamidino-2-phenylindole; ns, no significance.
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PMC9429973
No organomegaly was detected.
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PMC6600592
C NMR (CDCl3) δ 198.23 (C-7), 172.29 (C-10), 136.66 (C-1), 133.14 (C-4), 128.59 (C-2, 6), 128.01 (C-3, 5), 72.90 (C-14), 33.44 (C-8), 31.57 (C-15, 19), 28.69 (C-9), 25.37 (C-17), 23.71 (C-16, 18) .
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PMC11367939
Our previous study and recent proteomic analysis clearly revealed that ATG9A vesicles are not SVs but represent unique vesicle pools in nerve terminals .
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PMC11243198
Consistent with previous reports , we observed that U87MG cells express both GLI1 and GLI2 and that T98G expresses predominantly GLI1 (Figure 5A and Supplemental Figure S5).
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PMC11549612
Validation of BOLA1, BOLA2, and BOLA3 promoter methylation levels and mutational analysis in extended kidney renal clear cell carcinoma (KIRC) cohorts via the OncoDB, UALCAN, GSCA, and cBioPortal databases.
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PMC11622247
The donor dyes are blue-shifted by only 5–20 nm relative to the QB/TO nucleotides, allowing simultaneous excitation of both dye groups with efficient energy transfer.
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PMC9429973
In preclinical models of MM, TQB3602 displayed potent kinase inhibiting activity for 20S proteasome enzyme with IC50 15.3 nM. It also inhibited cell proliferation in the MM.1S cell line with IC50 10.1 nM. In the MM.1S MM CB-17 CDX model, TQB3602 also showed antitumor efficacy.
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PMC10999934
A total of 799 DEGs were identified among these cells, including 445 upregulated genes and 354 downregulated genes (Fig. 3B).
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PMC11785489
We removed innate-like cells (transcriptional cluster A9) from regressions focused on CD8T, Treg, or memory T cell fate.
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PMC11698348
Whole cell protein lysates were extracted from cultured cells using RIPA lysis buffer (50mm Tris-HCl, 1% NP-40, 0.25% sodium deoxycholate, 150mm NaCl, and 1mm EDTA; pH 7.4) and cOmplete ULTRA Protease Inhibitor Cocktail (Merck, UK).
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PMC11271800
TAMs can help tumor cells evade immune surveillance and clearance by establishing an immunosuppressive microenvironment.
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PMC11740207
They are a specialized subset of MsPCs that, under appropriate in vitro conditions, can differentiate into various cell types, including osteoblasts, chondrocytes, adipocytes, and even nerve cells.
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PMC9454178
The combination index (CI) was generated by CompuSyn software, and CI < 1, = 1, and > 1 indicate synergic, additive or antagonistic effects, respectively.
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PMC11738017
The sBCMA levels from these cocultures are presented in Figure 3D.
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PMC11727907
ATP standard solutions, ranging from 10 to 10 M, were used for calibration (luciferin/luciferase ATP bioluminescence assay kit CLS II, Roche, Basel, Switzerland).
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PMC11228511
The primer sequences are listed in SI Appendix, Table S3.
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PMC11754094
These Cas9 RNP complexes were added to the CRISPRi-stable HeLa cell line after lentiviral transduction and puromycin selection for CRISPRi screening.
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PMC9503685
The effects of ceragenins and AMPs on the adhesion of P. aeruginosa on the A549 cell line were most pronounced with CSA-13; CSA-13 completely prevented P. aeruginosa adhesion at 2, 4, and 6 h at a concentration of 20 mg/L. The ability of CSA-13 to inhibit bacterial adhesion was also shown in the fluorescent images in Figure 4.
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PMC7917457
PeptiCRAd, in combination with anti-PD1, improves tumor growth control and survival compared to either monotherapy and triggers a systemic anti-tumor memory response in a syngeneic mouse model of B16.F10.9/K1 (A) Anti-PD-1 immune checkpoint inhibitor alone (200 μg/dose given intraperitoneally), 1 × 10 VP of PeptiCRAd VALO-mD901-Trp2 alone, or in combination with anti-PD-1 immune checkpoint inhibitor were given intratumorally 9, 10, 11, 12, 13, and 26 days post-tumor implantation.
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PMC11711127
Exhausted T cells are a heterogeneous population that shows attenuated (but not absent) function in the context of persistent Ag exposure.
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