Datasets:
OTAR3088
/
BioData-CellLine_annotated

Dataset card Data Studio Files
xet
 Community
1
PMCID
string
Sentences
string
ner
list
PMC8164677
Intracellular platinum-DNA binding levels in A2780 and A2780 calculated in response to sequential (0/0, 0/4 and 4/0 h) drug administration; data are expressed as means ± SEM (n = 3); and analyzed by ANOVA (two-way) followed by multiple comparison test (post hoc Bonferroni) using the software Graph Pad Prism-6. **
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11740508
However, in a 2009 genetic analysis of BRCA1 and BRCA2 sequences from 46,276 women, the C61G mutation was found to be prevelant in 2.3% of western europeans, and 6.4% of central europeans .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973
Results: From a total of 13 patients we have found a mutation causing erythrocytosis in 6 of them, among which there are two family clusters.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10380508
Relative expression levels of the reference genes are shown in Supplementary Figure S2.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Relative", "expression", "levels", "of", "the", "reference", "genes", "are"...
PMC11589157
Considering the highly repetitive sequences on the Y-chromosome increased the difficulty and inaccuracy for gene prediction, genes with CDS covered by over 60% of repeats were excluded.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973
Results: Median overall survival (OS) and event-free survival (EFS) were 276 and 135 days (d).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":...
PMC11297139
b Representative confocal images showing the cellular localization of different GFP-BAF complex subunits.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "b", "Representative", "confocal", "images", "showing", "the", "cellular", "...
PMC11381192
HMOX1 belongs to both HESI and HYSI; SOD1 belongs to both HESI and OSI; AIFM1 and PARK7 belong to both OSI and ERSI; PARP1 belongs to both OSI and GSI; CDKN1A belongs to both OSI and HYSI. (
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7602170
Five p85 isoforms are encoded by the p85-related genes (PIK3R1, PIK3R2 and PIK3R3), which are referred collectively as the consequence of splice variants.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11348300
This feature positions it as an ideal indicator for tissue malignancy, particularly where chronic or transient hypoxia prevails.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "feature", "positions", "i...
PMC6600253
Other drugs that are currently being investigated for the ability to induce senescence by modulating the cell cycle machinery are the CDK inhibitors.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Other",...
PMC6684588
For example, 55% of fibers from ACE-083-injected TA muscles were at least 51 μm in diameter, whereas only 6% of fibers from contralateral, uninjected TA muscles reached that threshold (Fig. 3D).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973
A. Abomhya, Z. Abdulsada, H. Hamad Internal Medicine, The Brooklyn Hospital Center, Brooklyn; Internal Medicine, Meharry Medical College School of Medicine, Nashville, United States of America; Faculty of Medicine, Al-Azhar University, Cairo, Egypt Background: Inflammatory bowel disease (IBD) patients are at a significantly high risk of thromboembolism events.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11128598
After 1 h of incubation, medium was aspirated, and formazan crystals were dissolved in DMSO (100 μL/well).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "1", "h",...
PMC11763126
Meanwhile, RENCA cell line and C57BL/6 mice were used in Flow cytometric analysis of CD8+ T cells in subcutaneous tumors.
[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "...
PMC11753435
Binary accuracy is the accuracy of the model in predicting the correct binding pairs when given two protein-peptide pairs.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Binary", "accuracy", "is", "the",...
PMC11791203
The anticancer properties of 2,4-di-tert-butylphenol have been a focal point in recent research.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "anticancer", "properties", "of", "2,4-di-tert-butylphenol", "have", "been"...
PMC9429973
Lactate can be imported and exported by monocarboxylate transporters (MCTs).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Lactate", "can", "be", "imported", "and", "exported", "by", "monocarboxylate", "...
PMC10606998
For both glioma cell lines, no cytotoxic effect was observed over the entire range of analyzed concentrations of SPIONs (Figure 2).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11486946
EGFR fractions shifted from small to large oligomers with higher EGF concentrations.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "EGFR", "fractions", "shifted", "from", "small", "to", "large", "oligomers", "wit...
PMC11244823
The true positive result in the Icelandic horse serum remains unexplained.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "true", "positive", "result", "in", "the", "Icelandic", "horse", "serum", "rema...
PMC11240052
Wu et al., 2022 showed that miR-211-5p suppressed the invasion, migration, proliferation, and progression of CRC cells through sponging SPARC-related growth factor pathways (38).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11764090
Effects of 10 h cold-temperature treatment in A. thaliana were similar to those caused by pathogen infection, including increased expression of the SA pathway marker genes PR2 and PR5, as well as increased expression of genes that play an active role in defense against (hemi)-biotrophs .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973
Overall survival (OS) at 3 years was 32% and 24%, median OS was 13.3 months vs 10.2 months (univariate HR:0.83, 95%CI 0.58-1.18, p=0.3) for CPX -351 and FLAG-Ida respectively (Figure 1a).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11487720
F Dominant negative (DN)-p53 significantly blocked UV/cold shock-mediated BCD.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "F", "Dominant", "negative", "(DN)-p53", "significantly", "blocked", "UV/cold", "shock-mediated", "BCD", "."...
PMC11377827
Immunoblot of the nuclear fraction of HeLa-Cas9 incubated in 1% oxygen for 0 to 60 min.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Immunoblot", "of", "the", "nuclear", "fr...
PMC8873393
Cluster 7 contains chromatin associated transcripts, with much lower expression levels in the cytoplasm relative to the other clusters.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cluster", "7", "contains", ...
PMC11723947
Mouse Treg were isolated from the spleen of B6 Foxp3-Thy1.1 mice.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mouse", "Treg", "were", "isolated", "from", "the", "spleen", "of", "B6", "Foxp3-Thy1....
PMC9429973
Transcriptome analyses revealed that BTM-3566 activates the ATF4-integrated stress response (ISR), indicated by phosphorylation of eukaryotic translation initiation factor 2α (eIF2α) and upregulation of the stress transcription factor ATF4.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11476222
The ZIC-HILIC column provided the best separation of ganglioside GD1 isomers with a 25 min runtime.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "ZIC-HILIC", "column", "provided", "the", "best"...
PMC11621493
Statistical comparisons in (B) were performed with one-way ANOVA followed by Bonferroni posthoc analysis.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Statistical", "comparisons", "in", "(", "B", ")", ...
PMC11247842
However, some limitations of these analyses include: (1) the extensive LD in the cattle genome could lead to spurious enrichments; (2) the enrichment of a specific tissue should not lead to the conclusion of the causality of such tissue to the trait of study, because the tissue collection is broad but not complete and, in addition, regulatory elements overlap among tissues; and (3) regulatory elements are only predicted by bioinformatic analysis without final experimental validation.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10507284
The conduction of western blot was consistent with the previously described.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "conduction", "of", "western", "blot", "was", "consistent", "with", "the", "pre...
PMC8336407
Different concentrations of standards were prepared in 60% methanol.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Different", "concentrations", "of", "standards", "were", "prepared", "in", "60", "%", "methanol"...
PMC9351137
Cells were stained with DAPI (blue) and anti-α-tubulin (green).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "stained", "with", "DAPI", "(", "blue", ")", "and", ...
PMC9080589
They are expressed predominantly in the nervous system.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "They", "are", "expressed", "predominantly", "in", "the", "nervous", "system", "." ] } ]
PMC11082662
SMPDL3B, sphingomyelin phosphodiesterase acid-like 3B; qRT-PCR, quantitative real-time polymerase chain reaction.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "SMPDL3B", ",", "sphingomyelin", "phosphodiesterase", "acid-like", "3B", ...
PMC11342785
Two-tailed Student t test; statistical differences: ∗∗∗∗, p < 0.0001; ∗∗∗ p < 0.001; n.s.,
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Two-tailed", "Student",...
PMC8922418
Yin et al. demonstrated the feasibility and effectiveness of using an all-in-one AAV vector containing multiple gRNAs/SaCas9 to interfere with HIV-1 provirus in three different animal models.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11656657
Long-term tumor control of CAR.GD2 T-cells in an in vitro co-culture assay of RMS and OS models under "stressed" conditions.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Long-term", ...
PMC11279397
It also influenced the proliferation of herpes simplex virus type 1 (HSV-1) and pseudorabies virus (PrV), without exhibiting cytotoxic effects at the tested concentrations .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11576293
Collectively, most of the test derivatives have comparable docking scores to co-crystallized ligands, Erlotinib and Sorafenib, against EGFR and VEGFR-2 proteins, and these scores were higher with S-benzyl methoxy derivatives than those of other congeners.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11740907
At transition temperature (Tg), the structure of the molecule changes from being rigid to flexible.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "At", "transition", "temperature", "(", ...
PMC11297139
d Representative confocal images illustrating the colocalization pattern of recombinant ARID1A proteins (green) and SMARCD1 (red).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "d", "Representative", "confo...
PMC11286266
Among those, the gene encoding the ER Hsp70 chaperone BiP (GRP78) has been well documented as an important ATF6α target (Adachi et al., 2008).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11536589
The western blot assay was conducted using the standard laboratory protocols.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "western", "blot", "assay", "was", "conducted", "using", "the", "standard", "la...
PMC9429973
Both MAC and reduced intensity conditioning (RIC) regimens are allowed.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Both", "MAC", "and", "reduced", "intensity", "conditioning", "(", "RIC", ")", ...
PMC9429973
Patient received one courses of chemotherapy according to the HR protocol, followed by 2 cy of Blinatumomab.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Patient", "received", "one", "courses", ...
PMC11612794
The pLDDT scores indicate that the aa 161–186 region of CENP-T has lower confidence (pLDDT <70), whereas the aa 187–216 region has higher confidence (pLDDT >70) and adopts a more reliable structure (Figure S3E).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973
The modified toxicity probability interval scheme-2 (mTPI-2) design will be used to perform dose escalation and MTD/RP2D determination, using dose increments from 25 mg to 400 mg once daily.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10748106
In Genipin these zones of more electron density also correspond to the carbonyl at C11, the sp3 oxygen of the ester at C11, the oxygen of the hydroxyl at C1, and the hydroxyl at C10.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973
Although the results should be interpreted with caution due to the premature termination of the study and limited follow-up, these further support the use of molecular MRD assessment to predict outcome in pts with AML.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11392912
Cells (SW982 and RAFLS) were grown till 60% confluency and transfected with Clo-miR-14 as mentioned above, washed, lysed with radio-immunoprecipitation assay lysis buffer (RIPA) (Thermo, U.S.A.) containing 1% (v/v) protease and phosphatase inhibitor cocktail (Gbioscience, U.S.A.), incubated (1 h) at 4°C and centrifuged at 15000 × g, at 4°C for 30 min.
[ { "tags": [ "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC11036064
In mice, miR-34a is mainly expressed in the brain, and miR-34b/c is predominantly expressed in the lung (Hermeking, 2010).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11672617
The cells were treated with the synthesized compounds at a concentration of CC50 and incubated (37 °C, 5% CO2) for 6 h. Following this period, the cells were dissociated with Accutase solution, stained, and analyzed by flow cytometry (NovoCyte Flow Cytometry™ (Agilent, Santa Clara, CA, USA)) in accordance with the manufacturer’s protocols.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973
Three months after CR, she complained headache, diplopia and paralysis of the right eyes.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Three", "months", "after", "CR", ",", "she", "co...
PMC9429973
Although several clinical data have been reported, the requirement of intensive chemotherapy, including dose-adjusted R-EPOCH (DA-R-EPOCH), for DEL and TEL is still controversial.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11715478
Intergroup variations were also observed in the subsets of CD4CD8TCRgd T cells (P=0.0002) and CD4CD8TCRgd T cells (P=0.0004).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Intergroup", ...
PMC10723784
For example, the IC50 values for CBD in A2780 cells were 12.3 ± 0.7 μM, 6.8 ± 1.07 μM, 4.5 ± 0.2 μM, and 3.5 ± 0.2 μM following 24, 48, 72, and 96 h contact times which were lower when compared to those in non‐carcinoma cells, ARPE19 and PNT2 cells (Table 2). (
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9844987
We identified 29,001 active promoters of 15,994 annotated genes (Frankish et al., 2019) through positional clustering of proximal CAGE-inferred TSSs on the same strand (Figure 1A; Carninci et al., 2006) detected in at least 10% of individuals (Supplementary file 2).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11532793
Aiming to optimize computing time while maintaining full statistical efficiency, we evaluated the necessary number of resamples for DTE analyses.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aiming", "to", "o...
PMC11727638
Figure 7 shows the viability of cells exposed to 10, 100, and 1000 nM of DOX.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Figure", "7", "shows", "the", "viabili...
PMC11615828
We next tested whether dimerization between VOIs and MTs can be triggered by the CID system.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "next", "tested", "whether", "dimerization", "bet...
PMC11742231
The metrics were calculated using identical benchmark datasets and settings for all approaches.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "metrics", "were", "calculated", "using", "identical", "benchmark", "...
PMC9429973
However, its genomic features including novel therapeutic vulnerabilities remain sparsely characterized.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "its", "genomic", "features", "including", "novel", "therapeutic", ...
PMC11087766
P. aeruginosa cells expressing the indicated sfGFP-tagged PhiKZ nuclear protein infected with either PhiPA3 or PhiKZ. (
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "P.", "aeruginosa", "cells", "expressing", "the", ...
PMC9429973
Besides, it was also identified as ABCB1 inhibitor.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Besides", ",", "it", "was", "also", "identified", "as", "ABCB1", "inhibitor", "." ] } ]
PMC9429973
Figure 1) 3yrs-OS was again superimposable in the two arms: 83% (95%CI: 69%-91%) in the RIT vs 85% (95% CI: 72%-91%) in the ASCT, p = 0.8310 (HR 1.10, 95%CI: 0.45,2.72).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973
One patient received HLA identical SCT from a family donor, one patient underwent matched and another mismatched unrelated donor SCT, 5 patients received haploidentical SCT: oneunmanipulated with post-transplant cyclophosphamide and 4 with B- T α/β depleted graft.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973
Methods: This is a noninterventional, single-arm, post-authorization study (EudraCT: 2021-001684-24) in adult pts with BPDCN prescribed TAG under real-world routine clinical practice conditions (12 mcg/kg intravenously [IV] once daily on days 1–5 of a 21-day cycle, per the summary of product characteristics recommendation).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9424261
4HERPUD1 downregulates GSH by reducing the protein level of GSS.A, B GSH and Fe content in liver cancer cells with or without HERPUD1 after adding erastin, RSL3, CA.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11496491
Through bioinformatics analysis, the corresponding signaling pathways of differential gene enrichment were identified, among which Inflammatory mediator regulation of TRP channels may participate in the improvement process of postoperative peripheral neurodegeneration.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973
Plasma Gln (µmol/L) reduction from baseline occurred in 4/5 (80%) pts within cycle 1: pt4 423→273 (Day15), pt5 446→86 (Day28), pt6 467→216 (Day22), pt7 388→156 (Day8), pt10 420→395 (Day10).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11731614
We detected GFP signal after immunolabel amplification in cryosections of the DRGs from the EV-reporter mice for both RD and HFD.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "detected", ...
PMC11766309
Table 1Correlation Analysis Between YKT6 Expression and Clinicopathological Characteristics in 26 Cervical Cancer PatientsCharacteristicsCases, nYKT6 Expression Levelχ²P-ValueHigh, nLow, nPatients (N)26Age0.0010.97≤50 years19811>50 years734Pathology0.150.69Squamous cell carcinoma1358Adenocarcinoma1367Lymph node metastasis0.820.36None23914Yes321Grade5.11<0.05*Low grade16412High grade1073Stage3.350.067(Tx/T0/T1)17512(T2-T4)963Notes: Comparisons were considered statistically significant when *p < 0.05.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11144382
pCMVTag2C was used as a negative control. (
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "pCMVTag2C", "was", "used", "as", "a", "negative", "control", ".", "(" ] } ]
PMC11437637
Some studies have shown that tumor burden reduction may reduce or eliminate cancer-associated inhibitory factors and cells, thereby reducing immune suppression .
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Some", "stud...
PMC9429973
Image: Summary/Conclusion: This study illustrates the real-world effectiveness of FEDR after RUX failure in patients with Int- or HR MF.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Image", ":",...
PMC10968586
Treatment of K562 cells with 100 μM HT produced transcriptional effects including the downregulation of IL-10 receptor and the upregulation of inflammatory mediators IL-6 and IL-8 .
[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5311252
TGFBR2 also has a negative impact on cell proliferation as TGFBR2 signaling results in the upregulation of several different CDK inhibitors including CDKN1A.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "TGFBR2"...
PMC9429973
U.P. and L.A. contributed equally to this study as senior authors M. C. Köse, I. Bergiers, M. Malfait, B. Heidrich, D. De Maeyer, N. Fourneau, B. Verbist, J. Van Houdt, G. Vanhoof, R. Verona, M. Delforge, J. Depaus, N. Meuleman, J. Van Droogenbroeck, P. Vlummens, C. J. Heuck, N. Bahlis, J. Caers, T. Casneuf Laboratory of Hematology, University of Liege, Liege; Janssen Research & Development, Beerse; Department of Applied Mathematics, Computer Science and Statistics, University of Ghent, Ghent, Belgium; Janssen Research & Development, Spring House, United States of America; University Hospital Leuven, Leuven; Department of Hematology, CHU UCL Namur, Yvoir; Service d’Hématologie, Université Libre, Brussels; Departmentof Haematology, AZ Sint-Jan Brugge-Oostende AV, Brugge; Department of Clinical Hematology, Ghent University Hospital, Ghent, Belgium; Department of Hematology and Oncology, University of Calgary, Calgary, Canada Background: Multiple Myeloma (MM) is an incurable plasma cell (PC) malignancy that evolves from two premalignant stages: Monoclonal Gammopathy of Undetermined Significance (MGUS) and Smoldering Multiple Myeloma (SMM).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6450504
The highest number of early apoptotic cells was achieved in the 0.5%PEIPOS group after 48 h of continuous treatment.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "highest", "number", "of", ...
PMC9429973
Image: Summary/Conclusion: Utilizing a machine learning-enabled analysis of multidimensional data from 48 patients, we identified Hispanic ethnicity and renal dysfunction at the time of diagnosis (sCr ≥ 1.6) as key factors that may impact patient responses between the end of induction therapy and at 100 days post-transplant.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11670407
For mitochondrial ROS assay, cells were trypsinized and resuspended in a culture medium.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "mitochondrial", "ROS", "assay", ",", "cells", "were", "tr...
PMC11345828
The combined organic layers were washed with sat.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "combined", "organic", "layers", "were", "washed", "with", "sat", "." ] } ]
PMC10213179
Furthermore, time to gastrocnemius muscle surgery was significantly extended by the ATOP aptamer (Figure 8D).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "time", "to", "gast...
PMC9424261
C, D Bel-7402 and Bel-7404 cells were seeded at an appropriate density in six-well plates and cultured for 24 h, then treated with: 10 μM erastin or 5 μM RSL3; 10 μM CA; pretreatment with 10 μM CA for 1 h followed by 10 μM erastin or 5 μM RSL3; 2 μM ferroptosis inhibitor Fer-1, in complete medium for 24 h. Cell death was quantified by SYTOX-Green staining followed by flow cytometry.
[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC11708541
The sciatic nerve crush injury and no-injury groups of mice were divided into groups, and observed with or without 4-AP and saline treatment evaluating the skeletal muscle's morphological, functional, and transcriptional characteristics.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8382973
Containment of the AIDS pandemic requires reducing HIV transmission.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Containment", "of", "the", "AIDS", "pandemic", "requires", "reducing", "HIV", "transmission", "." ] }...
PMC6892818
As positive controls for p-MKK4/7, p-JNK and p-p38 protein expression induction, lysates from HCT116 cells that were treated with control (‘C’) or treated with mCD40L (‘mL’) for 6 h were included.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11594588
This will enable the facilitation of faster diagnostics and the identification of platelet mitochondrial damage by clinicians and scientists in order to implement adequate therapeutic procedures and minimize the risk of the induction of cardiovascular diseases, including ischemic events correlated with them.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11750712
In contrast to findings in PB, in all five of five patients with posttreatment lymph nodes accessible to biopsy and suitable for testing (median 11 days after CAR T, range 7–279 days), both IF and ddPCR confirmed infiltration of AUTO4 CAR T cells at these tumor sites.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10759659
These results imply a more aggressive biological feature and worse overall survival of HBV-HCC with ARID1A deficiency.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "results", "imply", "a", "more", "a...
PMC11786767
The sample size “N” indicates the number of examined cells.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "sample", "size", "“", "N", "”", "indicates", "the", "number", "of",...
PMC9429973
Results: Severe COVID19 (CT 3-4 severity) was more often observed in patients in ETP (100%) than in LTP (45%) (p=0.021).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11367939
Both ATG9A- and synaptophysin-positive vesicles were labeled by the endocytic tracer, cholera toxin-horseradish peroxidase (CTX-HRP) (Fig. 1B), suggesting that both ATG9A- and synaptophysin-positive vesicles undergo exo- and endocytosis (Fig. 1B).
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11507371
A431 and HaCaT cells acquired at CLS (Cell Line Service, Eppelheim, Germany) were used in all experiments.
[ { "tags": [ "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A431", ...
PMC11740399
Drug Loading Capacity (DLC) and encapsulation efficiency (EE) were calculated using the following formulas: [12pt] $$DLC(\%) = } + } 100\%$$ [12pt] $$EE(\%) = }} 100\%$$ To evaluate the cellular uptake ability of 3025@ML, 2.5 × 10 T24 cells per well were allowed to grow in a 6-well plate for 48 h and incubated with PBS (as a control), 3025@ML and 3025@ML combination with filipin (inhibitors of caveolin-1) at 37 °C and 3025@ML at 4 °C.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11568601
C The expression of BAX protein was enhanced and BCL-2 protein was reduced by TGT treatment, as detected by western blot experiment.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "C", ...
PMC11714165
10 µM of NBD, NBD‐F, or NBD‐T was added to confocal dishes (diameter: 35 mm) when the 143B cells reached 90% confluence.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", ...