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PMC11295144
HEK293 cells were voltage-clamped at −40 mV using an Axopatch 200B amplifier (Molecular Devices, United States), and whole-cell currents (IPSCs or drug-activated) were filtered at 5 kHz (−36 dB), digitized at 50 kHz via a Digidata 1322A (Molecular Devices), and recorded to a Dell Optiplex 990 using Clampex 10.2 (Molecular Devices).
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PMC11632064
Rho-0 cells were also less potent at inducing CXCL8 and IL6 in response to RSK and PLK1 inhibitors (Fig 6N and O).
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PMC9429973
Aims: To achieve the targeted AML treatment by virtue of MnO2 nanostructure-based immune- and chemotherapy synergy.
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PMC9370419
The docking was conducted, and the results were visualized using Pymol.
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PMC11244823
The day prior to transfection, 12 million cells were seeded in a 150cm tissue culture flask (TPP AG) and incubated for 24h at 37°C and 5% CO2.
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PMC11190538
Cell viability was calculated as a percentage of the mean value of optical density obtained from cell controls, which was set at 100 %.
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PMC11617590
Using an electrophoretic mobility shift assay (EMSA), SFN inhibited the binding of NF‐κB dimers in Mia PaCa‐2 cells .
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PMC5941560
Jurkat cells were obtained from ATCC (clone E6-1).
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PMC9429973
Median OS in prior Gilt exposed pts was 6.3 months and ≥1 prior FLT3i exposed pts was 6.3 months.
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PMC11546117
This in vitro tool offers the potential to generate evidence supporting the use of medicines during lactation at an early stage of drug development.
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PMC10253973
Furthermore, ruthenium complexes demonstrate epigenetic activities, e.g., interaction with biomolecules, including coordination to the nucleosome core, formation of adducts with histones and inhibition of topoisomerase II.
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PMC9429973
Secondary aims were survival outcomes by different subpopulations based on standard of care (SoC) treatment regimens and transplant status.
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PMC11244823
A paired t-test was performed to compare the RLU of each antigen (Prism 10, Version 10.0.2, Graphpad); p-values ≤ 0.05 were considered statistically significant and marked with an asterisk.
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PMC11772585
These cell lines were cultured in Dulbecco’s Modified Eagle’s Medium (DMEM, Gibco, USA) supplemented with 10% fetal bovine serum (FBS, ThermoFisher, USA) and 1% penicillin-streptomycin.
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PMC9428827
After the primary tumors were 6–7 mm in diameter, the mice were sacrificed, and the tumors were collected and analyzed by flow cytometry.
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PMC11770746
prodrugs are inert, six-coordinate complexes, which are usually obtained by H2O2 oxidation of the four-coordinate square planar Pt(II) drugs, resulting in the addition of two hydroxido axial ligands that can be chemically modified.
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PMC7823217
These models should mimic in vivo tumors and microenvironment and include strategies for recapitulating surrounding fibrous tissue containing barrier proteins .
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PMC11525028
ROC analysis of three marker combinations (NAT10, ATF4, and ASNS) and NAT10 in OS (left) (combination: AUC = 0.772, NAT10: AUC = 0.645) and LMFS (right) (combination: AUC = 0.817, NAT10: AUC = 0.688) in the osteosarcoma patient cohort, by Venkatraman method test.
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PMC11361748
After dual TPA Tx, the signal for phospho-PKCα is primarily concentrated in the epidermis and is significantly stronger in WT compared to Krt17 null skin (Fig 5A and 5B).
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PMC7709199
Elution from the Mono Q column was performed with a linear gradient, in which the IL-12B homodimer eluted at a conductivity of 16 mS cm.
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PMC9874064
Furthermore, the inhibitory effect of NP-Pt-USP1i on HR proteins in tumor cells was also explored.
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PMC11794847
Manipulating HVEM expression revealed its essential role in T cell survival and activation.
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PMC11612794
Error bars show the mean ± SD; p-values were calculated by one-way ANOVA (F (2,27) = 262.6; p < 0.0001) followed by Tukey’s test. (
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PMC6034753
Although the molecular mechanisms of selective induction of tumor cell apoptosis by apoptin are not fully understood, its tumor cell–restricted nuclear translocation is thought to be important.
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PMC11615743
Therefore, L‐DNA‐based logic devices have great potential for target‐cell identification and isolation in complex environments.
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PMC10523483
Adeno-Cre, adenoviruses expressing Cre, 1 × 10 pfu per mouse via intranasal inhalation. (
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PMC10213179
Tumor volume was calculated according to the formula (L × l/2), where L is the longer diameter and l the shorter diameter.
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PMC10671321
A new culture medium composed of DMEM, 10% horse serum treated with ISO OMPA (5 × 10 mol/L; SIGMA) for 1 h at RT to inhibit any exogenous cholinesterase activity), 1% L-glutamine, 1% penicillin-streptomycin and 1 mg/mL heparin (SIGMA) was added to the cells.
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PMC11742231
However, their generalizability is often constrained by the cancer type and available biomarkers, reducing their broader applicability.
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PMC11637276
MDA-MB-231 cells were transfected with an siRNA targeting MAP3K1 (siMAP3K1) or a non-targeting siRNA control (siNT) and spheroids embedded in 3D 3 mg/ml pHrodo-labelled collagen I and matrigel (1:1 ratio) mixture for 4 days.
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PMC11474209
Physical control, involving the alteration of reservoir outflows to facilitate downstream flushing of cyanobacterial blooms, is a viable approach, particularly suitable for benthic cyanobacteria .
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PMC8658661
This was discovered after an investigation by Lopez-Terrada D. et al. on the nature of HepG2.
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PMC9429973
Patients must be ≥18 years old for Part 1 and ≥12 years old for Part 2.
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PMC11087301
So, inhibition of PKD-1 signaling may induce the deletion of subpopulations of CSC to restrict the development of pancreatic neuroendocrine malignancies, curative resistance and metastasis .
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PMC9429973
Methods: Pts aged ≥18 years (yrs) with a known medical history of α- or β-thalassemia, Hb concentration ≤10.0 g/dL, and ≤5 RBC units transfused in prior 24 wks and none in 8 wks prior to study drug were eligible.
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PMC3995603
B: Histamine production was reduced by AC in PMA and A23187 (PA)-treated (50 nM and 1 μM, 24 hr) MC/9 cells (mean ± SEM (n = 3), : P < 0.01 compared with the control group, **: P < 0.01 compared with the PA-treated group).
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PMC11621493
P value > 0.05) (supplemental Fig. S8B and C).
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PMC10203589
In terms of its clinical relevance, FGF18 is a valid diagnostic indicator in GC (43, 44).
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PMC11612626
LLVY-R110 and Suc-LLVY-MCA are cleaved by both the β5c subunit and β5i subunit, whereas ANC-ANW-AMC is cleaved specifically only by the β5i subunit.
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PMC10213179
At the endpoint of the experiment, mice were euthanized, lungs were harvested, and an ex vivo IVIS reading was performed.
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PMC9429973
Results: Only 1 DLT (autoimmune hepatitis [grade 4]) was identified among the first 6 patients from all cohorts included in part 1 at the favezelimab 200 mg dose; thus, the dose was escalated to 800 mg.
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PMC11742290
However, high LGR5 protein expression was also found to be a significant independent predictor of increased OS in CRC .
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PMC11656380
A successful peptidic NOTCH inhibitor, SAHM1, primarily inhibits NOTCH-dependent pathways, similar to the action of GSIs.
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PMC11591052
As serine is derived from glycolysis intermediate 3-phosphoglycerate, one-carbon metabolism links glycolysis with different biosynthetic processes that result in DNA and RNA biosynthesis, protein biosynthesis, and the maintenance of the redox and methylation states of cells .
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PMC9429973
The trial is now continuing to the randomized phase (Part 2).
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PMC9429973
Image: Summary/Conclusion: Our study illustrated the crucial role of ASXL1 mutation in MPN phenotypes and BM fibrosis.
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PMC9429973
Methods: The LYSA R-ACVBP strategy include four cycles of R-ACVBP (75 mg/m doxorubicin, and 1200 mg/m cyclophosphamide; 2 mg/m vindesine and 10 mg bleomycin on days 1 and 5) with four IT, two cycles of high dose methotrexate (3g/m), four cycles of R-etoposide (300 mg/m) and ifosfamide (1500 mg/m) and 2 cycles of cytarabine(100 mg/m) given sub cutaneously for 4 days.
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PMC9429973
Cytokine release syndrome (CRS) occurred in 3 out of 5 patients.
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PMC11721295
P values were then corrected using the Benjamini and Hochberg method.
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PMC11543853
The final volumes were subjected to post-processing in RELION.
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PMC11143482
The tumour-bearing mice exhibited lethargy, cyanosis of lips, and decreased appetite following 15 days post injection of HOS-143B cancer cell line.
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PMC11803149
Statistical analysis was performed with RM two-way ANOVA with Fisher’s LSD test (A-C) or unpaired t-tests (E).
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PMC11773391
Then, the cells were incubated with the CoraLite 594‐conjugated goat anti‐rabbit IgG secondary antibody (Proteintech; 1:400) diluted in TBS mixed with DAPI (1, 10,000) for 1 h at room temperature in the dark.
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PMC11248911
Docking setup was first validated by self-docking of bestatin as the co-crystallized ligand in the vicinity of the binding site of the target enzyme, which showed a docking score (S) of −9.4 kcal mol and root mean square deviation (RMSD) of 0.70 Å. Molecular docking study showed that compound 8 attained promising ΔG values of −8.1, kcal mol against APN, as shown in Table 4.
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PMC10778532
It slows down from 24 h whereas for WT VHL it slows down from 48 h. We next compared the ability of proliferation by measuring Ki67 cells for the 3 cell lines after treatment with sunitinib at 72 h (Figure 4D).
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PMC9341513
MYEOV shows more frequent interactions with the CCND1 promoter than with the IGH insert, despite the latter being closer genomically (arrows ‘vii’).
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PMC9684669
Using a quantitative high-throughput combinational screen, we identified that terfenadine restored doxorubicin sensitivity in an MDR ovarian cancer cell line.
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PMC11025866
Cellular gene expression is a controlled process that is responsive to various stimuli.
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PMC11623887
This DDR seems to help B19 replication, subsequently, NS1intracts with E2F and induces G2 phase cell cycle arrest, viral genome itself induce S-phase arrest in EPCs and erythropoiesis.
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PMC8345486
Hierarchical cluster analysis was used to characterize the diversity of compound potency against ovarian cancer cells (Figure 3C).
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PMC11471157
Intriguingly, most spheroids were predominantly composed of a single cell type, yet a small proportion exhibit a mosaic composition of different cell types (Fig. 3N and O).Fig.
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PMC9429973
The distribution of CCSS groups [Very Good (3%), Good (43%), Intermediate (22%), Poor (10%), Very Poor (21%)] and R-IPSS risk categories [Very low (5%), low (30%), Intermediate (27%), High (17%), Very high (20%)].
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PMC11264242
These findings opened the question of whether FYN antagonizes the sensitivity of synovial sarcoma cells to HDACi treatment.
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PMC9429973
Aims: To analyse the impact of histological G3A in clinical characteristics and evolution of patients with FL in comparison with grades 1 and 2 FL.
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PMC10470467
Here, the univariate Cox analysis was used for preliminary screening, and NRGs with a value of p <0.05 were considered prognosis-related candidate genes.
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PMC4839679
The cell suspension (100 μl) was placed in a Falcon tube and was sequentially incubated in annexin V-FITC (5 μl) followed by PI (5 μl) at 20°C–25°C in the dark for 15 min.
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PMC11387401
Western blot was performed to confirm the specific pulldown of the HIV-1 protein (Appendix Fig. S1).
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PMC8140214
Atboth 48 and 72 hr time-points, quercetin could improve these conditions compared to the corresponding values in HepG2 cells treated with 30 and 50 mM D-glucose, respectively (p<0.05).
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PMC11085211
In this work, we showed that an extract from Arbutus unedo L. leaves (indicated as AUN) induces early apoptosis in GIST cells, exerting chemotherapeutic properties.
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PMC9841531
Until today, only roughly 100 compounds are known to interact with MCT1.
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PMC8708099
no. 3470-1H-20, IL-6—cat.
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PMC11026382
The DHFR backbone is in gray cartoon (PDBID: 1RX2).
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PMC11463018
9 or on the website (https://www.reactionbiology.com/services/target-specific-assays/epigenetic-assays/hdac-assays/).
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PMC8922418
However, both ZFN and TALEN have limitations, such as low gene editing efficiency, high off-target rate, and costly and laborious vector construction.
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PMC11746948
We observed that GPX4, a crucial inhibitor of ferroptotic cell death, undergoes palmitoylation.
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PMC10142392
They can be functionalized with a variety of molecules, making them ideal for targeted drug delivery.
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PMC9046263
Previous studies using microarrays have suggested that extensive transcriptional activity of HML-6 exists in a wide variety of normal tissues, including the brain.
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PMC11700165
All constructs were sequenced and the presence of the corresponding protein was verified.
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PMC9516447
GRP78 knockdown reduced KRAS protein in all three cell lines.
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PMC11549062
The results showed that the expression of PDGFR‐β was significantly enhanced or decreased by overexpression or knockdown of PTP1B, respectively.
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PMC9429973
The study included hospitalized patients diagnosed with COVID-19 infection: 161 patients with LPD and 162 patients from the GP.
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PMC11371747
Modulation of 5FU sensitivity by LV-stereoisomers. (
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PMC8097906
Possible therapy strategies are limited and chemoresistance due to genetical and metabolic alterations are frequently leading to tumor recurrences and metastatic invasion.
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PMC11387401
However, despite the fact the positive control with PMA reactivated J-Lat 10.6 to around 40%, we could not detect an effect on reactivation in the ASO-treated conditions that was different from the scrambled ASO control.
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PMC11283030
The median follow-up time was 47.2 months, ranging from 20 to 76 months.
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PMC11190062
The reduction in drug sensitivity was dependent on TLR signaling since the protective effect of TLR activation was lost in TLR4 and TLR9 KO cells ( Figures 3C, D ; Supplementary Figures 2A, B ).
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PMC11291697
Pathway enrichment analysis was performed by integrating different bioinformatic tools (ToppGene, GeneNetwork, Enrichr, Ingenuity Pathway Analysis, and GeneGlobe) and top enriched pathways were selected for further investigations.
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PMC11806818
In the presence of CEA, the CEA aptamer preferentially binds to CEA and releases it from the surface of MoS2 NSs, leading to a decrease in the catalytic activity of MoS2 NSs.
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PMC11345828
The crude residue was purified by flash column chromatography eluting with either EtOAc/hexanes to afford the desired compound.
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PMC9581083
Biologically active compounds found in M. officinalis include 4-O-methylhonokiol, honokiol, magnolol, obovatol, and other neolignan compounds.
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PMC11088135
Depending on the degree of malignancy, gliomas are graded from I to IV.
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PMC11730305
Additionally, treating ovarian carcinoma cells with Ellagic acid caused cell cycle inhibition, mainly at the G1 phase, induction of p53, and enhanced activity of caspase-3 which inhibits cell proliferation and induces apoptotic pathways.
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PMC10582049
Using chest CT-scan analysis, LUAD patients were stratified into 2 groups with predicted indolent and aggressive tumor behavior. (
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PMC11634027
Scale bar: 100 µm. (
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PMC9429973
Penpulimab, an anti-PD1 antibody of IgG1 isotype, has demonstrated high response rate and very good tolerance, and is now approved in R/R classic Hodgkin lymphoma.
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PMC9812014
HNJ had a substantial antiviral efficacy against IAV, with an inhibitory concentration EC50 of 10.4 μg/mL .
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PMC11718274
One such factor is the mitochondrial ND3 gene that encodes the mitochondrial respiratory chain complex I subunit, and triggers apoptosis releasing pro-apoptotic factors into the cytosol.
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PMC11783017
Afterward, the expression of IL-11Ra proteins were evaluated by protein-blots analysis.
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PMC11696576
RNA-Seq and ribosome-associated RNA(Ribo)-Seq was performed by Eclipsebio (eclipsebio.com).
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PMC9429973
These findings might be related to the distinct etiology of the studied anemias.
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