OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC11786704	The comparison of substances that regulate the MAPK pathway reveals that although synthetic inhibitors are effective, they have significant side effects and toxicity issues, limiting their clinical application.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11530949	Real-time PCR analysis was employed to determine relative gene expression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Real-time", "PCR", "analysis", "was", "employed", "to", "determine", "relative", "gene", "expres...
PMC9429973	Here, we show that CD20-TCB treatment induced the activation, proliferation and migration of previously exhausted patient CD4 and CD8T cells and triggered the release of immunostimulatory cytokines related to immune cell recruitment and cytotoxic function.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11704135	C NMR (CDCl3) δ(ppm) of compound 14: 178.65, 171.51, 151.81, 146.82, 141.37, 138.57, 130.99, 34.34 and 30.34.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6487404	Roswell Park Memorial Institute-1640 (RPMI 1640), Dulbecco›s modified Eagle›s medium (DMEM), fetal bovine serum (FBS), penicillin-streptomycin solution and Hank’s balanced salt solution (HBSS) were obtained from Biowest (Germany).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11052306	The dendriplexes were also shown to be more active against MCF-7 cells than the dendrimers alone.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "dendriplexes", "were", "also", "shown", ...
PMC9412887	Western blotting results further expounded that CEPH and ultrasound was able to observably inhibit the expression of EGFR, down-regulate the level of HIF-1α and increase the level of ROS, which ultimately contribute to the cooperative antitumor effect.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11564405	This intricate quest will delve into the unknown effects of RILPL2 in the complex environment of NSCLC in an effort to reveal the ambiguous aspects of its involvement in the immune environment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11672142	The protein was then washed by spin dialysis to rid the unreacted protein.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "protein", "was", "then", "washed", "by", "spin", "dialysis", "...
PMC10728200	IM was dissolved in dimethyl sulfoxide (DMSO, #HY-Y0320, MCE), and diluted in PBS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "IM", "was", "dissolved", "in", ...
PMC11711871	This exon encodes for the second zinc finger, including the DNA-binding and dimerization domains .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "exon", "encodes", "for", "the", "second", "zinc", ...
PMC9429973	In fact, 35.3% (6/17) MCD DLBCLs were only identified by ctDNA but not by gDNA, suggesting the addition of ctDNA genotyping substantially improved the detection rate of MCD subtype (figure 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11786600	Thus, PEDs show great promise for advancing research of personalized diabetic wound healing.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "PEDs", "show", "great", "promise", "for", "advancin...
PMC11683240	The complexes PT-α1AT were obtained by blind docking using three different web servers, HawDock Server (http://cadd.zju.edu.cn/hawkdock/), GRAMM Docking Web Server (https://gramm.compbio.ku.edu/), and AlphaFold3 (https://alphafoldserver.com/) (64, 65, 66, 67, 68, 69).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11786156	No other significant characteristics were observed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No", "other", "significant", "characteristics", "were", "observed", "." ] } ]
PMC11566417	To obtain single cells, digested tissue material was filtered through 100 µm and then 40 µm cell strainers and then seeded at 1 × 10 cells were per well of a 6-well tissue culture plate for 1 h (h), allowing adherent cells to attach.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Approximately 37% and 35%, without MMR response at baseline, reached at least an MMR at three months and last follow up, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11697065	On the day of harvest, cells were counted, and the culture supernatant was used for titre measurement using an Octet QK384 (ForteBio, Menlo Park, CA, USA) with Protein A biosensors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8557138	Intra-individual variations in response to anti-angiogenic drugs due to differential gene expression of endothelial cells among the population often pose an obstacle to for clinical management of solid tumors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9024365	For testing the expression of SD4/IFITM3 chimeras, membranes were incubated with anti-SD4, anti-IFITM3, and anti-tubulin antibodies at 4C overnight.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "testi...
PMC9429973	Aims: LOOMIS was a single-centre observational cohort study that evaluated the relative merits of DW-MRI and bone turnover markers in prospectively assessing tumour burden and bone disease when added to standard clinical assessment, in patients with MM and monoclonal gammopathy of undetermined significance (MGUS).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11743316	As a result, CRL4 and BIRC3 may be possible targets for individuals with recurrent ovarian cancer after treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "a", "result", ",", "C...
PMC10551595	Moreover, a hydrogen bond (O4 in the hydroxyl group) was formed with Cys124, (bond length: 2.51 Å) (Figure 7A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11740508	We conclude tht Tala + Deci treatment impairs the ability of cells to produce viable colonies, and that this drug sensitivity is enhanced by BRCA mutation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	PFS and OS were 1.7 years (95% CI 1.6-1.9) and 3.7 years (95% CI 3.4-4.2), respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11724582	The data from the acute and DTP groups in the PC9, NCI-H1975, HCC827, and HCC2935 cell lines were analyzed using cell lines as covariates.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", ...
PMC10988555	Data normalized against the DMSO control (value represented as a dot line at y = 1) and expressed as the mean ± SEM of three independent assays.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11786156	To investigate the relationship between CD54 and vascular invasion or the Ki-67 index of tumor cells in DLBCL cases, we assessed extravascular and intravascular Ki-67 indices and the expression of CD54 and CD11a using immunohistochemistry (IHC).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Methods: Forty-three patients (65%) were treated with nivolumab and 23 (35%) with pembrolizumab.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "Forty-three"...
PMC9429973	Finally, we analyzed whether EPAG could rescue AA BM in presence of their matching serum, pre- and post- ATG treatment (n=6).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11592837	To detect γH2AX by flow cytometry, we used the H2A.X Phosphorylation Assay Kit (Merck, Millipore, Burlington, MA, USA) according to manufacturer’s instructions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Further studies are needed to understand the prognostic impact and clinical significance of these findings.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Further", "studies", "are", "needed", "to", "understand", "...
PMC9429973	Methods: We studied acute lymphoblastic leukemia (ALL) as model disease and combined long-term in vivo treatment in orthotopic patient-derived xenograft (PDX) models with multi-omics profiling and functional genomic CRISPR/Cas9 screens.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8922418	Due to the COVID-19 pandemic caused by SARS-CoV-2 in the past year, Abbott et al. developed the prophylactic antiviral CRISPR method in human cells (PAC-MAN) based on Cas13d to target SARS-CoV-2 and all sequenced coronavirus strains (Abbott et al., 2020).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11129910	A clean, sterile 200 μl pipette tip was used to make a scratch across the well.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "clean", ",", "sterile", "200", "μl", ...
PMC9429973	Aims: BRUIN is a phase 1/2 multicenter study (NCT03740529) of oral pirtobrutinib monotherapy in pts with advanced B-cell malignancies who have received ≥2 prior therapies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11604830	The latter, in particular, are generally used for detecting the F MRI signal in cellular imaging applications, while in this work, the attention was focused on its proton‐rich surfactant component.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11772585	J TUNEL staining of HSC-1 and A431 cells was performed (n = 3).	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "J", "TUNEL", "staining", "of", "HSC-1", "and", ...
PMC9429973	Aims: In light of data scarcity and future changes in second line therapy for relapsed/refactory patients, we aimed to analyse the suitability of 4 survival prognostic indices in a DLBCL cohort.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5173112	USP21-mediated histone H2A ubiquitylation can affects transcriptional initiation through its impact on H3K4 di- and trimethylation .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "USP21-mediated", "histone", "H2A", "ubiquitylation", "can", ...
PMC11659921	Vascular endothelial growth factor (VEGF) is a critical molecule in tumor angiogenesis, and inhibiting VEGF has demonstrated promising therapeutic effects across various cancers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11791432	Meanwhile, we found that the expression of ANXA1 in the recurrent samples was higher than that in the primary samples with significant differences (P < 0.001) (Fig. 2K-L).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Further studies are required to prove the benefit of zanubrutinib when added to R-CHOP for newly-dignosed DE-DLBCL.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Further", "studies", "are", "required", "to", ...
PMC9429973	Results: Distribution of demographic data and prognostic factors was comparable between LDFCR and BR groups.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "Distribution", "of", "demographic", "d...
PMC11747885	This derivative 47 was also found to inhibited Rlig1-AMP at 10 μM concentration (Fig. 3B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "derivative", "47", "was", "also", "...
PMC10253973	This complex exhibited effective phototoxicity at 625 nm and luminescent activities typical of the triplet excitation state.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "complex", "exhibited", "effective", "phot...
PMC10898159	In the absence of ligand, SMO starts to activate the hedgehog pathway .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "the", "absence", "of", "ligand", ",", "SMO", "starts", "to", ...
PMC11604768	We performed hierarchical clustering to classify common and specific promoter responses (Fig. 3a).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "performed", "hierarchical", "clustering", "to", "classify",...
PMC9429973	A 100.0% ORR were observed with 3 (33.3%) pts achieved CR/sCR, 3 pts (33.3%) were VGPR, 3 pts were PR (33.3%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11653533	Additionally, the study found that the extracts have a more significant antioxidant activity compared to vitamins C and E. Furthermore, the fruits of this plant and honey can prevent iron-mediated lipid peroxidation of low-density lipoprotein.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11755467	Overall, the results suggest less efficient DICER1 processing of pre-miR-132 in the presence of Enoxacin compared to the DMSO control .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Overall", ",", "t...
PMC11765678	Recently, ferroptosis inducers are being recognized as a significant step forward for the treatment of many cancers and to overcome drug resistance .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Recentl...
PMC10482220	During the course of these experiments, we noticed that cells transfected with G3BP-GFP concentrated the protein in aggregates resembling SGs, even in the absence of any arsenite treatment (Fig. 4, panel 4).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9813422	During latency, KSHV maintains 50-100 genome copies per infected cell (11).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "During", "latency", ",", "KSHV", "maintains", "50", ...
PMC11551844	β-Sitosterol displayed anticancer activities on various cancer cell lines and has been shown to act by enhancing apoptosis, inducing cell cycle arrest, bidirectionally regulating oxidative stress, improving metabolic reprogramming, inhibiting invasion and metastasis, modulating immunity and inflammation, and combating drug resistance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	More studies should be performed to establish more risk factors, helping us to identify poor mobilizers more accurately and initiate Plerixafor mobilization early on, to be able to improve the engraftment and to decrease the relapse rate accordingly.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10813895	These findings suggest that the ON-OFF regulation of ELF5 expression, linked to the level of DNA methylation, is essential for preserving cell-specificity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11694066	To obtain the complete organoid medium, the basal medium was supplemented with 1 mmol/L N-acetylcysteine (#A72250, Sigma-Aldrich), 10 mmol/L nicotinamide (#N0636, Sigma-Aldrich), 10 ng/mL recombinant human RSPO3 (#120-44, PeproTech), 10 ng/mL recombinant human Wnt3A (#HZ-1296, Proteintech), 10 ng/mL leukemia inhibitory factor (LIF; #HZ-1292, Proteintech), 25 ng/mL recombinant human IL22 (#HZ-1325, Proteintech), 10 pg/mL IL6 (#HZ-1019, Proteintech), 50 ng/mL recombinant human FGF-basic (#100-18B, PeproTech), and 100 ng/mL recombinant human insulin-like growth factor (IGF; #100-11, PeproTech).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11489275	RP-ILD was defined as dyspnea and hypoxemia within 3 months with the progression of imaging findings .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "RP-ILD", "was", "defined", "as", "dyspnea", "and", ...
PMC9429973	Image: Summary/Conclusion: In the modified-ITT population we found no statistically significant benefit of the addition of rituximab to MBVP on EFS, PFS and OS in patients with PCNSL, even after a long follow-up of median 82 months.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11705067	The GSE53757 and GSE66272 datasets was downloaded from the GEO database (https://www.ncbi.nlm.nih.gov/geo/), which includestumor samples and matched adjacent paracancerous tissues from 99 patients with ccRCC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11618052	The viability of new compounds 8a–t was evaluated using the MCF-10A normal human mammary gland epithelial cell line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "viability", "of", ...
PMC11683240	After denaturation of the samples, gel electrophoresis, and Western blotting were performed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "denaturation", "of", "the", "samples", ",", "gel", "ele...
PMC10713411	Autophagy was reported to be a survival pathway and quality-control mechanism to suppress tumor progression during early tumorigenesis, while when tumors progress to the advanced stage, autophagy promotes the survival, growth and metastasis of established tumors .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4270159	The cell viability assays examining drug sensitivity and the Western blots examining levels of phosphorylated kinases in Figures 2B and 2C, respectively, are the key experiments that demonstrate that growth factor ligands can reactivate downstream signaling components important for cancer cell survival, causing resistance to anticancer kinase inhibitors (Wilson et al., 2012).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10890055	Zn-0.8Mg-0.2Ag was prepared as follows: Commercially available zinc (99.995 wt%), magnesium (Magnesium Elektron, Manchester, UK, 99.95 wt%), and silver (Safina, a.s.,	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11483468	Telomerase is activated in most cancer cells, and thus telomerase is an ideal target for cancer therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Telomerase", "is", "activated", "in", ...
PMC6468656	The common sites of metastasis include lung, lymph node, bone and brain .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "common", "sites", "of", "metastasis", "include", "lung", ...
PMC11727907	Spectrophotometric analysis of the samples was conducted before and after the addition of 4 μg of purified hexokinase (HK) and glucose-6-phosphate dehydrogenase (G6PD).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11470999	High CIP2A expression was associated with reduced patient survival (Figures 4B and S4).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "High", "CIP2A", "expression", "was", "associated", "with", ...
PMC5417661	For xenografts, 8 weeks old NMRI nu/nu female nude mice were used as follows; 8 animals in the vehicle group, 6 animals in each dose group of NOV202 and 6 animals in the paclitaxel group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11489351	Importantly, DAPT treatment under high pHi conditions reduced the signal of the Notch1 activity reporter to that observed under control conditions (Fig. 4E).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9473868	These results indicated that BAI inhibited FLSs proliferation and EMT, whereas induced cell apoptosis through blocking the PI3K/Akt/mTOR pathway, supporting clinical application for RA progression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11467800	Zebrafish have become a widely used model organism due to their ability to be easily and inexpensively maintained, their high reproductive output, their rapid and transparent embryonic development and their suitability for various techniques such as transgenesis, live cell imaging, cell lineage tracing and micromanipulation. , ,	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11739670	Briefly, T‐cells were stimulated by autologous APCs exogenously loaded with peptide and expanded in culture for up to 3 weeks.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Briefly", ",", "T...
PMC11566417	Neutrophils were fixed, stained with crystal violet, and imaged on a light microscope (Olympus).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Neutrophils", "were", "fixed", ",", "s...
PMC11401350	The statistical tests applied are indicated in the figure legends.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "statistical", "tests", "applied", "are", "indicated", "in", "the", "figure", "legends", ...
PMC11740207	Due to ethical constraints, detailed studies on primitive human EpibCs are limited; however, in vivo research provides valuable insights.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Due", "to", ...
PMC9429973	Adverse events (AEs) were predominantly grade 1 and not related to treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Adverse", "events", "(", "AEs", ")", "were", "predominantly", "g...
PMC9429973	For the baseline data, median tumor volume were 152.8 cm3 (4.3-1,542.5 cm3) & 172.2 cm3 (6.4-2,349.7 cm3), median sIL-2R serum were 304 U/mL (24-1,625 U/mL) & 417 U/mL (13-1,897 U/mL), median TNF-α serum were1.95 pg/mL (1.2-4.2 pg/mL) & 1.65 pg/mL (0.8-6.7 pg/mL) in control and subject group respectively, there were no statistically significant differences in these results.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10607604	As this new analysis did not confirm PTPN13’s prognostic value, we compared the characteristics of patients/tumors included in this new series and in the previous series.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11594074	Compounds 2 and 4, therefore, progressed onto cytotoxicity testing in four cancer cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Compounds", "2", "and", "4", ",", "therefore", "...
PMC11574271	The matrix invasion assay was carried out using trans-well chambers (8 mm pore diameter) as previously described.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "matrix", "invasion", "assa...
PMC10470467	GSE17679 and GSE63157 cohort: (A) (D) the risk-score, survival status, and 6 key genes expression heatmap; (B,E) Kaplan–Meier survival analysis; (C,F) time-dependent ROC curves of the signature.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	These mutations drive aberrant activation of downstream proliferation pathways and are associated with a high risk of relapse.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "mutations", "drive", "aberrant", ...
PMC10440586	Kaplan-Meier curves of the GLASS dataset.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Kaplan-Meier", "curves", "of", "the", "GLASS", "dataset", "." ] } ]
PMC9119314	7-iodocryptolepine (5) and 7, 9-diiodocryptolepine (6) were prepared as above except that N-iodosuccinimide (NIS) was used in place of NBS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4270159	This prevents power calculations being performed a priori to determine the sample size (number of biological replicates).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "prevents", "power", "calc...
PMC11752740	In response to the side effects often associated with conventional chemical treatments, researchers are increasingly exploring plant-based compounds for cancer therapy [21–23].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11655536	E The expression of Ki67 between control and HA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "E", "The", "expression", "of", "Ki67", "between", "control", "and", "HA", "." ] } ]
PMC11695546	Through the application of oxidizing chemicals that are effective towards microorganisms without causing antibiotic resistance, new and exciting methods for treating biofilms have emerged.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11615828	Synaptic vesicles deliver neurotransmitters along MTs from the cell body (soma) to synaptic sites in neuronal cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Synaptic", "vesicles", "deliver", ...
PMC10938336	This analysis provided valuable insights into the potential roles and functions of these genes within various biological contexts.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "analysis", "provided", "valuable", ...
PMC9429973	The median time to a platelet count of ≥50×10/L was also comparable across groups, ranging from 8 to 17 days, and the median (IQR) increase in platelet count to ~Day 57 was 84.5×10/L (36.5-165.6).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	STR profiles were analyzed using GeneMapper v.4 software (Applied Biosystems, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "STR", "profiles", "were", "analyzed", "using", "GeneMapper", "v.4", ...
PMC11472569	Recent studies have emphasized the role of ABCG2 in the function and composition of EVs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Recent", "studies", "have", "emphasized", "the", "role", "o...
PMC11683240	Conversely, for subunit S4_1, nonpolar interactions (van der Waals, hydrophobic) are more essential than electrostatics ones.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Conversely", ",", ...
PMC11675244	Resveratrol, a phytophenol previously identified as a Wnt inhibitor, has been tested in patients with colorectal cancer and healthy ones.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Resveratrol", ...
PMC9429973	In patients aged ≥65 years, AA patients continued to have a longer TTP than whites (9.8 vs 5.2 years, p = 0.02).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC8540611	HeLa cells were grown in full DMEM with stable glutamine, 4.5 g/L glucose (Life Technologies, Paisley, UK), 10% FBS (Life Technologies, Paisley, UK), 100 U/mL penicillin, and 0.1 mg/mL streptomycin (MilliporeSigma, Burlington, MA, USA) at 37 °C in humidified air atmosphere with 5% CO2.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11786704

The comparison of substances that regulate the MAPK pathway reveals that although synthetic inhibitors are effective, they have significant side effects and toxicity issues, limiting their clinical application.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11530949

Real-time PCR analysis was employed to determine relative gene expression.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Real-time", "PCR", "analysis", "was", "employed", "to", "determine", "relative", "gene", "expres...

PMC9429973

Here, we show that CD20-TCB treatment induced the activation, proliferation and migration of previously exhausted patient CD4 and CD8T cells and triggered the release of immunostimulatory cytokines related to immune cell recruitment and cytotoxic function.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11704135

C NMR (CDCl3) δ(ppm) of compound 14: 178.65, 171.51, 151.81, 146.82, 141.37, 138.57, 130.99, 34.34 and 30.34.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC6487404

Roswell Park Memorial Institute-1640 (RPMI 1640), Dulbecco›s modified Eagle›s medium (DMEM), fetal bovine serum (FBS), penicillin-streptomycin solution and Hank’s balanced salt solution (HBSS) were obtained from Biowest (Germany).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11052306

The dendriplexes were also shown to be more active against MCF-7 cells than the dendrimers alone.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "dendriplexes", "were", "also", "shown", ...

PMC9412887

Western blotting results further expounded that CEPH and ultrasound was able to observably inhibit the expression of EGFR, down-regulate the level of HIF-1α and increase the level of ROS, which ultimately contribute to the cooperative antitumor effect.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11564405

This intricate quest will delve into the unknown effects of RILPL2 in the complex environment of NSCLC in an effort to reveal the ambiguous aspects of its involvement in the immune environment.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11672142

The protein was then washed by spin dialysis to rid the unreacted protein.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "protein", "was", "then", "washed", "by", "spin", "dialysis", "...

PMC10728200

IM was dissolved in dimethyl sulfoxide (DMSO, #HY-Y0320, MCE), and diluted in PBS.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "IM", "was", "dissolved", "in", ...

PMC11711871

This exon encodes for the second zinc finger, including the DNA-binding and dimerization domains .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "exon", "encodes", "for", "the", "second", "zinc", ...

PMC9429973

In fact, 35.3% (6/17) MCD DLBCLs were only identified by ctDNA but not by gDNA, suggesting the addition of ctDNA genotyping substantially improved the detection rate of MCD subtype (figure 1).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11786600

Thus, PEDs show great promise for advancing research of personalized diabetic wound healing.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", "PEDs", "show", "great", "promise", "for", "advancin...

PMC11683240

The complexes PT-α1AT were obtained by blind docking using three different web servers, HawDock Server (http://cadd.zju.edu.cn/hawkdock/), GRAMM Docking Web Server (https://gramm.compbio.ku.edu/), and AlphaFold3 (https://alphafoldserver.com/) (64, 65, 66, 67, 68, 69).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11786156

No other significant characteristics were observed.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "No", "other", "significant", "characteristics", "were", "observed", "." ] } ]

PMC11566417

To obtain single cells, digested tissue material was filtered through 100 µm and then 40 µm cell strainers and then seeded at 1 × 10 cells were per well of a 6-well tissue culture plate for 1 h (h), allowing adherent cells to attach.

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PMC9429973

Approximately 37% and 35%, without MMR response at baseline, reached at least an MMR at three months and last follow up, respectively.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11697065

On the day of harvest, cells were counted, and the culture supernatant was used for titre measurement using an Octet QK384 (ForteBio, Menlo Park, CA, USA) with Protein A biosensors.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8557138

Intra-individual variations in response to anti-angiogenic drugs due to differential gene expression of endothelial cells among the population often pose an obstacle to for clinical management of solid tumors.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9024365

For testing the expression of SD4/IFITM3 chimeras, membranes were incubated with anti-SD4, anti-IFITM3, and anti-tubulin antibodies at 4C overnight.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "testi...

PMC9429973

Aims: LOOMIS was a single-centre observational cohort study that evaluated the relative merits of DW-MRI and bone turnover markers in prospectively assessing tumour burden and bone disease when added to standard clinical assessment, in patients with MM and monoclonal gammopathy of undetermined significance (MGUS).

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PMC11743316

As a result, CRL4 and BIRC3 may be possible targets for individuals with recurrent ovarian cancer after treatment.

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PMC10551595

Moreover, a hydrogen bond (O4 in the hydroxyl group) was formed with Cys124, (bond length: 2.51 Å) (Figure 7A).

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PMC11740508

We conclude tht Tala + Deci treatment impairs the ability of cells to produce viable colonies, and that this drug sensitivity is enhanced by BRCA mutation.

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PMC9429973

PFS and OS were 1.7 years (95% CI 1.6-1.9) and 3.7 years (95% CI 3.4-4.2), respectively.

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PMC11724582

The data from the acute and DTP groups in the PC9, NCI-H1975, HCC827, and HCC2935 cell lines were analyzed using cell lines as covariates.

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PMC10988555

Data normalized against the DMSO control (value represented as a dot line at y = 1) and expressed as the mean ± SEM of three independent assays.

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PMC11786156

To investigate the relationship between CD54 and vascular invasion or the Ki-67 index of tumor cells in DLBCL cases, we assessed extravascular and intravascular Ki-67 indices and the expression of CD54 and CD11a using immunohistochemistry (IHC).

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PMC9429973

Methods: Forty-three patients (65%) were treated with nivolumab and 23 (35%) with pembrolizumab.

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PMC9429973

Finally, we analyzed whether EPAG could rescue AA BM in presence of their matching serum, pre- and post- ATG treatment (n=6).

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PMC11592837

To detect γH2AX by flow cytometry, we used the H2A.X Phosphorylation Assay Kit (Merck, Millipore, Burlington, MA, USA) according to manufacturer’s instructions.

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PMC9429973

Further studies are needed to understand the prognostic impact and clinical significance of these findings.

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PMC9429973

Methods: We studied acute lymphoblastic leukemia (ALL) as model disease and combined long-term in vivo treatment in orthotopic patient-derived xenograft (PDX) models with multi-omics profiling and functional genomic CRISPR/Cas9 screens.

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PMC8922418

Due to the COVID-19 pandemic caused by SARS-CoV-2 in the past year, Abbott et al. developed the prophylactic antiviral CRISPR method in human cells (PAC-MAN) based on Cas13d to target SARS-CoV-2 and all sequenced coronavirus strains (Abbott et al., 2020).

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PMC11129910

A clean, sterile 200 μl pipette tip was used to make a scratch across the well.

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PMC9429973

Aims: BRUIN is a phase 1/2 multicenter study (NCT03740529) of oral pirtobrutinib monotherapy in pts with advanced B-cell malignancies who have received ≥2 prior therapies.

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PMC11604830

The latter, in particular, are generally used for detecting the F MRI signal in cellular imaging applications, while in this work, the attention was focused on its proton‐rich surfactant component.

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PMC11772585

J TUNEL staining of HSC-1 and A431 cells was performed (n = 3).

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PMC9429973

Aims: In light of data scarcity and future changes in second line therapy for relapsed/refactory patients, we aimed to analyse the suitability of 4 survival prognostic indices in a DLBCL cohort.

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PMC5173112

USP21-mediated histone H2A ubiquitylation can affects transcriptional initiation through its impact on H3K4 di- and trimethylation .

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PMC11659921

Vascular endothelial growth factor (VEGF) is a critical molecule in tumor angiogenesis, and inhibiting VEGF has demonstrated promising therapeutic effects across various cancers.

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PMC11791432

Meanwhile, we found that the expression of ANXA1 in the recurrent samples was higher than that in the primary samples with significant differences (P < 0.001) (Fig. 2K-L).

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PMC9429973

Further studies are required to prove the benefit of zanubrutinib when added to R-CHOP for newly-dignosed DE-DLBCL.

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PMC9429973

Results: Distribution of demographic data and prognostic factors was comparable between LDFCR and BR groups.

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PMC11747885

This derivative 47 was also found to inhibited Rlig1-AMP at 10 μM concentration (Fig. 3B).

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PMC10253973

This complex exhibited effective phototoxicity at 625 nm and luminescent activities typical of the triplet excitation state.

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PMC10898159

In the absence of ligand, SMO starts to activate the hedgehog pathway .

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PMC11604768

We performed hierarchical clustering to classify common and specific promoter responses (Fig. 3a).

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PMC9429973

A 100.0% ORR were observed with 3 (33.3%) pts achieved CR/sCR, 3 pts (33.3%) were VGPR, 3 pts were PR (33.3%).

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PMC11653533

Additionally, the study found that the extracts have a more significant antioxidant activity compared to vitamins C and E. Furthermore, the fruits of this plant and honey can prevent iron-mediated lipid peroxidation of low-density lipoprotein.

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PMC11755467

Overall, the results suggest less efficient DICER1 processing of pre-miR-132 in the presence of Enoxacin compared to the DMSO control .

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PMC11765678

Recently, ferroptosis inducers are being recognized as a significant step forward for the treatment of many cancers and to overcome drug resistance .

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PMC10482220

During the course of these experiments, we noticed that cells transfected with G3BP-GFP concentrated the protein in aggregates resembling SGs, even in the absence of any arsenite treatment (Fig. 4, panel 4).

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PMC9813422

During latency, KSHV maintains 50-100 genome copies per infected cell (11).

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PMC11551844

β-Sitosterol displayed anticancer activities on various cancer cell lines and has been shown to act by enhancing apoptosis, inducing cell cycle arrest, bidirectionally regulating oxidative stress, improving metabolic reprogramming, inhibiting invasion and metastasis, modulating immunity and inflammation, and combating drug resistance.

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PMC9429973

More studies should be performed to establish more risk factors, helping us to identify poor mobilizers more accurately and initiate Plerixafor mobilization early on, to be able to improve the engraftment and to decrease the relapse rate accordingly.

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PMC10813895

These findings suggest that the ON-OFF regulation of ELF5 expression, linked to the level of DNA methylation, is essential for preserving cell-specificity.

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PMC11694066

To obtain the complete organoid medium, the basal medium was supplemented with 1 mmol/L N-acetylcysteine (#A72250, Sigma-Aldrich), 10 mmol/L nicotinamide (#N0636, Sigma-Aldrich), 10 ng/mL recombinant human RSPO3 (#120-44, PeproTech), 10 ng/mL recombinant human Wnt3A (#HZ-1296, Proteintech), 10 ng/mL leukemia inhibitory factor (LIF; #HZ-1292, Proteintech), 25 ng/mL recombinant human IL22 (#HZ-1325, Proteintech), 10 pg/mL IL6 (#HZ-1019, Proteintech), 50 ng/mL recombinant human FGF-basic (#100-18B, PeproTech), and 100 ng/mL recombinant human insulin-like growth factor (IGF; #100-11, PeproTech).

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PMC11489275

RP-ILD was defined as dyspnea and hypoxemia within 3 months with the progression of imaging findings .

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PMC9429973

Image: Summary/Conclusion: In the modified-ITT population we found no statistically significant benefit of the addition of rituximab to MBVP on EFS, PFS and OS in patients with PCNSL, even after a long follow-up of median 82 months.

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PMC11705067

The GSE53757 and GSE66272 datasets was downloaded from the GEO database (https://www.ncbi.nlm.nih.gov/geo/), which includestumor samples and matched adjacent paracancerous tissues from 99 patients with ccRCC.

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PMC11618052

The viability of new compounds 8a–t was evaluated using the MCF-10A normal human mammary gland epithelial cell line.

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PMC11683240

After denaturation of the samples, gel electrophoresis, and Western blotting were performed.

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PMC10713411

Autophagy was reported to be a survival pathway and quality-control mechanism to suppress tumor progression during early tumorigenesis, while when tumors progress to the advanced stage, autophagy promotes the survival, growth and metastasis of established tumors .

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PMC4270159

The cell viability assays examining drug sensitivity and the Western blots examining levels of phosphorylated kinases in Figures 2B and 2C, respectively, are the key experiments that demonstrate that growth factor ligands can reactivate downstream signaling components important for cancer cell survival, causing resistance to anticancer kinase inhibitors (Wilson et al., 2012).

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PMC10890055

Zn-0.8Mg-0.2Ag was prepared as follows: Commercially available zinc (99.995 wt%), magnesium (Magnesium Elektron, Manchester, UK, 99.95 wt%), and silver (Safina, a.s.,

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PMC11483468

Telomerase is activated in most cancer cells, and thus telomerase is an ideal target for cancer therapy.

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PMC6468656

The common sites of metastasis include lung, lymph node, bone and brain .

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PMC11727907

Spectrophotometric analysis of the samples was conducted before and after the addition of 4 μg of purified hexokinase (HK) and glucose-6-phosphate dehydrogenase (G6PD).

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PMC11470999

High CIP2A expression was associated with reduced patient survival (Figures 4B and S4).

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PMC5417661

For xenografts, 8 weeks old NMRI nu/nu female nude mice were used as follows; 8 animals in the vehicle group, 6 animals in each dose group of NOV202 and 6 animals in the paclitaxel group.

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PMC11489351

Importantly, DAPT treatment under high pHi conditions reduced the signal of the Notch1 activity reporter to that observed under control conditions (Fig. 4E).

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PMC9473868

These results indicated that BAI inhibited FLSs proliferation and EMT, whereas induced cell apoptosis through blocking the PI3K/Akt/mTOR pathway, supporting clinical application for RA progression.

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PMC11467800

Zebrafish have become a widely used model organism due to their ability to be easily and inexpensively maintained, their high reproductive output, their rapid and transparent embryonic development and their suitability for various techniques such as transgenesis, live cell imaging, cell lineage tracing and micromanipulation. , ,

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PMC11739670

Briefly, T‐cells were stimulated by autologous APCs exogenously loaded with peptide and expanded in culture for up to 3 weeks.

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PMC11566417

Neutrophils were fixed, stained with crystal violet, and imaged on a light microscope (Olympus).

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PMC11401350

The statistical tests applied are indicated in the figure legends.

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PMC11740207

Due to ethical constraints, detailed studies on primitive human EpibCs are limited; however, in vivo research provides valuable insights.

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PMC9429973

Adverse events (AEs) were predominantly grade 1 and not related to treatment.

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PMC9429973

For the baseline data, median tumor volume were 152.8 cm3 (4.3-1,542.5 cm3) & 172.2 cm3 (6.4-2,349.7 cm3), median sIL-2R serum were 304 U/mL (24-1,625 U/mL) & 417 U/mL (13-1,897 U/mL), median TNF-α serum were1.95 pg/mL (1.2-4.2 pg/mL) & 1.65 pg/mL (0.8-6.7 pg/mL) in control and subject group respectively, there were no statistically significant differences in these results.

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PMC10607604

As this new analysis did not confirm PTPN13’s prognostic value, we compared the characteristics of patients/tumors included in this new series and in the previous series.

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PMC11594074

Compounds 2 and 4, therefore, progressed onto cytotoxicity testing in four cancer cell lines.

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PMC11574271

The matrix invasion assay was carried out using trans-well chambers (8 mm pore diameter) as previously described.

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PMC10470467

GSE17679 and GSE63157 cohort: (A) (D) the risk-score, survival status, and 6 key genes expression heatmap; (B,E) Kaplan–Meier survival analysis; (C,F) time-dependent ROC curves of the signature.

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PMC9429973

These mutations drive aberrant activation of downstream proliferation pathways and are associated with a high risk of relapse.

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PMC10440586

Kaplan-Meier curves of the GLASS dataset.

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PMC9119314

7-iodocryptolepine (5) and 7, 9-diiodocryptolepine (6) were prepared as above except that N-iodosuccinimide (NIS) was used in place of NBS.

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PMC4270159

This prevents power calculations being performed a priori to determine the sample size (number of biological replicates).

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PMC11752740

In response to the side effects often associated with conventional chemical treatments, researchers are increasingly exploring plant-based compounds for cancer therapy [21–23].

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PMC11655536

E The expression of Ki67 between control and HA.

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PMC11695546

Through the application of oxidizing chemicals that are effective towards microorganisms without causing antibiotic resistance, new and exciting methods for treating biofilms have emerged.

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PMC11615828

Synaptic vesicles deliver neurotransmitters along MTs from the cell body (soma) to synaptic sites in neuronal cells.

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PMC10938336

This analysis provided valuable insights into the potential roles and functions of these genes within various biological contexts.

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PMC9429973

The median time to a platelet count of ≥50×10/L was also comparable across groups, ranging from 8 to 17 days, and the median (IQR) increase in platelet count to ~Day 57 was 84.5×10/L (36.5-165.6).

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PMC9429973

STR profiles were analyzed using GeneMapper v.4 software (Applied Biosystems, USA).

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PMC11472569

Recent studies have emphasized the role of ABCG2 in the function and composition of EVs.

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PMC11683240

Conversely, for subunit S4_1, nonpolar interactions (van der Waals, hydrophobic) are more essential than electrostatics ones.

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PMC11675244

Resveratrol, a phytophenol previously identified as a Wnt inhibitor, has been tested in patients with colorectal cancer and healthy ones.

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PMC9429973

In patients aged ≥65 years, AA patients continued to have a longer TTP than whites (9.8 vs 5.2 years, p = 0.02).

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PMC8540611

HeLa cells were grown in full DMEM with stable glutamine, 4.5 g/L glucose (Life Technologies, Paisley, UK), 10% FBS (Life Technologies, Paisley, UK), 100 U/mL penicillin, and 0.1 mg/mL streptomycin (MilliporeSigma, Burlington, MA, USA) at 37 °C in humidified air atmosphere with 5% CO2.

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