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PMC11082662
Subsequently, through bioinformatics methods, we found there to be an increased expression of SMPDL3B in ovarian cancer lesions compared to adjacent nontumor tissues.
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PMC9429973
The median of CITED2 gene pre-treatment and post-treatment expression levels were: 276.3 (range= 1-241221.7) and 2.6 (range= 0.006-86475.3) with a significant decrease in expression (p=0.005) after the combined treatment.
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PMC11770130
The hydrogel was injected into the iWATs or eWATs of wild-type (WT) C57BL6/J mice (Fig. 2e; Supplementary information, Fig. S3g).
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PMC9429973
Methods: This phase 2, open-label trial in patients with MF enrolled patients into 4 cohorts according to JAKi experience; all patients provided informed consent.
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PMC10452486
It is interesting to note that HLA-A2 (A*02:07, A*02:15N, A*02:18) has C (Table 4).
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PMC9786247
Similar results were obtained herein after infection with different C. burnetii strains.
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PMC10530622
Like AGXT, GRHPR and HOGA1 mRNA expression showed a significant inverse correlation with TGA content.
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PMC9688728
The final list of metabolites did not include identifications, the intensity of which, in relation to the blank, on at least one of the days, was less than three.
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PMC11747885
Selective targeting of Rlig1 could enhance our knowledge of its involvement in RNA maintenance mechanisms and potentially offer therapeutic applications.
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PMC11412721
Ackr4 mRNAs in untreated or doxorubicin-treated WT and Trp53 mouse embryonic fibroblasts (MEFs).
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PMC10698968
MF-R 3 cells have more nucleoli than 143B cells (Fig. 2G right), affirming their aggressive neoplastic behaviour.
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PMC11551844
The mass ion source and quadrupole were programmed at 230 °C and 150 °C, respectively.
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PMC10654497
Kaplan–Meier OS curve and ROC curve of the (C) training and (D) verification sets. (
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PMC11394730
The overall expression of ERK, p38, and JNK was not affected by emodin; however, the level of p-JNK was decreased, and the phosphorylated forms of ERK and p38 were markedly increased in a time-dependent manner .
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PMC11638255
Unexpectedly, the tumoral oncogene Mycn and its associated targets were also significantly downregulated (p < 0.0001), which is known to decrease tumor cell proliferation and increase immunogenicity and immune cell infiltration (Fig. 4c,d).Fig.
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PMC9817179
Whereas rigorous characterization of LLPS in vivo has been challenging and remains a question under active investigation (McSwiggen et al., 2019b), detection of discrete puncta that have a spherical shape, undergo fusion and fission, and dynamically exchange biomolecules with the surrounding according to FRAP is often considered evidence of putative LLPS in living cells.
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PMC11653533
Pharmaciological effects of common species of the genus Ficus.
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PMC9429973
First, significantly increased CLL proliferation independent of IGHV mutation status, which was abrogated in the absence of T cells, or by JAK inhibitors.
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PMC9429973
We set out to investigate the trajectory of the malignant CLL B cell clone and subclonal heterogeneity in IGLV3-21 cases in order to gain insight into the molecular pathogenesis of this unique amino acid exchange.
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PMC11727907
, phAKT (Ser473, D9E, cat.
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PMC7709199
The C-terminal 6×His tag enabled capture of the protein from the conditioned medium by immobilized metal-affinity chromatography (IMAC) followed by size-exclusion chromatography (SEC).
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PMC11541409
Ripretinib has better safety profile than sunitinib.
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PMC10006224
Genomic coordinates for all these loops can be found in Supplementary Data 1.
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PMC11569208
and 1-part Fetal Bovine Serum (Gibco, cat.
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PMC11680562
5-fluorouracil is a common, affordable anticancer agent with various applications, including antibacterial effects.
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PMC11228511
Mean ± SEM. ****
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PMC11337594
The discrepancy in LDH release from A375 cells between the two drugs indicates that they may exert inhibitory effects on A375 cell viability through disparate mechanisms.
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PMC10734950
For the controls, DMSO was used for the vehicle control; as a positive control, cells were treated with 1 mM H2O2, and untreated cells were used to evaluate the baseline of the dead cell population, acting as a negative control for cytotoxicity.
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PMC9516447
Fig. S2A).
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PMC9429973
The primary objective was complete response rate after 3 cycles of daratumumab with DCEP.
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PMC9429973
In several cases, coronavirus infection developed during a course of chemotherapy or in the periods between the treatment courses, and therefore these patients were transported to the department via Emergency Medical Services (EMS) from other medical facilities.
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PMC9429973
No difference was in sex (51% (18/35) men in G1 vs 45.7% (32/70) in G2, p = 0.67), IPI (71.4% (25/35) IPI≥3 pts in G1 vs 58.5% (41/70) IPI≥3 pts in G2, p=0.28) or extranodal (E) involvement (77.1% (27/35) pts with >1 E in G1 vs 71.4% (50/70) in G2, p=0.69).
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PMC11531735
Spectrophotometric readings at 570nm were obtained using a spectrophotometer.
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PMC9429973
Citations were screened and extracted by dual independent review.
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PMC7961460
Moreover, they secrete urokinase and a panel of MMPs and MMPs inhibitors (TIMP1 and TIMP2) and express some tumour-related cytokine m-RNAs (TGFb 1,-2, -3, and PTHrP).
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PMC11457557
Many possible genetic variations that contribute to illness vulnerability have been suggested through linkage studies and candidate gene techniques.
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PMC11696576
Based on the above experimental and computational data, we propose that GK420 may act as a prodrug, generating the corresponding acid, which strongly interacts with the active site of cPLA2α via multiple critical interactions.
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PMC3734024
Isolated B cell populations were routinely >95% pure.
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PMC11770199
NS versus mMSCs-p14, *P = 0.014; mMSCs-GFP versus mMSCs-p14, **P = 0.003, by one-way ANOVA with Dunnett’s multiple comparisons test. (
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PMC11575040
A Flowchart depicting the identification process of differentially expressed genes through NGS in two melanoma cell lines with and without metformin treatment.
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PMC11665584
The combination of single-cell and spatial transcriptomic analyses identified key factors driving the skin-to-oral keratinocyte lineage shift and neutrophil recruitment that may serve as targets for therapeutic modalities to treat cutaneous wounds.
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PMC11411004
A small-molecule dual-target inhibitor with anti-tumor activity has been designed and synthesized to specifically inhibit both HDAC and LSD1 (Duan et al. 2021), but it is not clear whether it has any effect on CHO cells.
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PMC7039683
C–E) Genome browser view for regions sharing this feature near RAP2B, KLF4, and PLAU.
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PMC10976516
Efficient clearance of tumor mass and antitumor efficacy partially mediated by monocytes and NK cells.
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PMC7215832
Image acquisition and analysis were carried out under full software control (SlideBook 5.0.0.18; Intelligent Imaging Innovations, Göttingen, Germany).
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PMC9429973
Expression of ICM was low on T-cells from 4/5 healthy individuals (Figure 1).
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PMC9429973
While such regimens have resulted in significant improvement of disease control and survival, the development of drug resistance remains a major clinical problem.
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PMC9429973
Image: Summary/Conclusion: The cellular response to BH3-mimetics is a complex emergent behaviour resulting from a combination of affinity, abundance and genetics, and is therefore challenging to predict.
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PMC11615218
However, this regulatory ability also dampens anti-tumor immune responses and favors tumor progression .
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PMC5025404
In the USA, adalimumab has been approved for the treatment of RA, psoriatic arthritis, ankylosing spondylitis, Crohn’s disease, ulcerative colitis, and chronic plaque psoriasis, but in Russia, this drug has only been registered for the treatment of RA.
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PMC10530622
The renal excretion of oxalate mainly occurs via glomerular filtration and tubular secretion, with the proximal tubule being a region of significant importance in this process due to its high expression of SLC26 transporters, specifically SLC26A6 and SLC26A1 .
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PMC7759933
The culture media was changed every 2–3 days to obtain the optimal growth of spheroids.
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PMC9429973
Grouped by functional groups, the most frequent were those related to DNA methylation (44.6 %) and signaling/kinase pathways (37.5%).
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PMC9429973
Finally, after confirming that cPCMDT1 is most abundant in the cytoplasm, in silico analysis and polysome profiling experiments indicated that cPCMDT1 encodes for a small protein.
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PMC11767817
Compound 2a-B significantly increased the expression of several proteins, indicating its potential as a multi-target therapeutic agent.
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PMC11740207
However, their unique ability to SD, grow, and proliferate distinguishes VSELSCs from exosomes and other cellular debris (Kucia M. J. et al., 2008; Ratajczak et al., 2019; Domingues et al., 2022).
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PMC11629143
Acetylated histones can be recognized by proteins with bromodomains, which have important roles in transcription regulation .
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PMC5839394
The biological synthesis of AgNPs have received increasing attention due to the growing need of developing eco-friendly (i. e. “green”) technologies in material synthesis [6,8–12].
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PMC11442172
This is, at least in part, due to the use of reductionist in vitro models in preclinical studies that fail to recapitulate the complex microenvironment that defines the heterogeneous metabolic landscape of human tumors (10, 11).
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PMC11621493
After centrifugation at 1,000 g for 10 min, the radioactivity in 100 μl of the upper phase was determined by liquid scintillation using AquaLight Beta (461-035, Hidex, Turku, Finland) and a Tri-Carb 2900TR liquid scintillation analyzer (PerkinElmer, Waltham).
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PMC10006224
b Left, scheme of the experiment.
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PMC10237474
In addition, our studies demonstrated that proteins which suffer from clipping when produced in CHO cells are found to be much less clipped when produced in HEK293 cells.
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PMC11271278
We also found significant enrichments of previously annotated oncogenes, and genes involved in cancer-related pathways in our identified HAPI gene lists (Fig. 1D and Supplementary Table 2).
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PMC8170755
Nm23-H1 has been down-regulated in highly metastatic tumors as mice lacking the Nm23-M1 gene developed lung cancer more frequently than wild-type controls (5).
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PMC11754784
b The logic flowchart and truth table of DNP2.
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PMC11711935
In hyperpigmentation disorders, such as melasma and solar lentigines, the secretion of pigmentation‐promoting factors increases, and the activity of key enzymes in melanin production is elevated.
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PMC11802855
To isolate the protein supernatant, cell lysates were subjected to centrifugation for 10–15 min.
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PMC11518702
C1ORF150 splice variant [rs56043070A], C1ORF150-Δexon2 encodes an in-frame protein with an exon-2 encoded 20-residue deletion and a Ser10 to Arg10 substitution ( Figure 2D , “isoform B”).
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PMC11694109
In addition, the analysis identifies heterogeneity of CD39 expression, an important immune checkpoint in cancer biology.
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PMC11743975
Hoechst 33342 was purchased from Sigma Aldrich (St. Louis, MO, United States, No. 14533).
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PMC11502443
Furthermore, we showed that tirzepatide is a biased agonist towards Gαs signaling and displayed similar activation of the wildtype and E354Q GIP receptor variants.
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PMC11574029
SPP1, also known as Osteopontin, is a multifunctional protein expressed in various cell types .
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PMC11627398
LIAS is an iron-sulfur cluster protein that can catalyze the final step of the biosynthesis of lipoic acid .
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PMC9429973
The beneficial effect is achieved enhancing erythroid EPO responsiveness, without affecting EPO levels per se.
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PMC11640419
Jun N-terminal kinases (JNKs) play a pivotal role in both extrinsic and intrinsic apoptotic pathways initiated by death receptors.
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PMC11471176
Consequently, the theoretical decoupling of cytotoxic effects and ACE2 upregulation through the administration of agents inhibiting ACE2 emerges as a promising therapeutic strategy in the nuanced management of aggressive breast cancer.
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PMC10812665
The findings on Rot and DES may appear surprising, but they confirm some earlier reports that described microtubules as additional targets relevant for the toxicity of these compounds .
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PMC10040136
Each group had 3 duplicates.
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PMC9429973
In particular, for 11 patients, BVD was, after having achieved at least a PR, a bridge to second auSCT, and for two patients a bridge to alloSCT.
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PMC11593713
We observed that a respiratory viral infection more significantly affected non-enzymatic oxidative stress markers in a lung adenocarcinoma model (A549 cells), while human lung fibroblasts (MRC-5 cell line) presented changes in enzymatic and non-enzymatic oxidative stress markers.
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PMC11767817
Treatment with compounds 2a and 2a-B did not result in the release of DNA fragments to the cell culture medium (Figure 7A).
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PMC3675084
Mammalian cells lacking survivin are unable to align their chromosomes and become polyploid at a very high frequency .
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PMC11684269
Also, GLUT1 enhances the proliferation of CD4 T cells and cytokine generation of Th1 and Th17, but not Treg and CD8 T cells (24).
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PMC7685376
Western blots of the expression levels of MCM proteins between 6 pairs of HCC tissues and adjacent normal tissues.
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PMC8557138
Increased expression of VEGF-A and SDF-1 locally in the tumor microenvironment recruits circulating EPCs to the tumors and undergo the process of neovascularization (Zhao et al. 2016).Pathological conditions including atherosclerosis, stroke, and delayed wound healing occur due to a shift in the molecular equilibrium of pro-angiogenic and anti-angiogenic factors leading to insufficient angiogenesis.
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PMC9429973
Collected Raman maps were processed with K-means cluster analysis (KMCA) followed by Principal Component Analysis (PCA) and Partial Least Squares–Discrimination Analysis (PLS-DA) performed on averaged spectra of cells and subcellular components.
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PMC9398137
Finally, we proposed mechanism-based treatment combinations that could enhance the activity of MCL1 inhibitors in aggressive B-NHL.
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PMC11047729
Telomestatin is a new inhibitor of telomerase that can be extracted from Streptomyces anulatus.
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PMC11697189
The mutation frequency of 22 HSP genes in 336 ccRCC patients from TCGA-STAD cohort.
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PMC11247842
However, we had 11 QTL without putative causal genes: BTA3:24.1 Mb, BTA9:10.5 Mb, BTA11:12.1 Mb, BTA13:56.9 Mb, BTA18:44.4 Mb, BTA19:31.5 Mb, BTA20:39.5 Mb, BTA21:57.1 Mb, BTA23:39.5 Mb, BTA25:38.5 Mb, and BTA29:46.6 Mb.
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PMC10142392
The choice of polymer used to form the core of a nanocarrier can have a direct impact on the drug solubilization, loading capacity, and release kinetics of the carrier.
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PMC10969097
CAFs play a crucial role in resistance to prostate cancer treatment, and the researchers aimed to clarify the underlying mechanisms of this resistance.
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PMC11678368
Moreover, the trans-[PdCl2(7AI3CA)2] complex demonstrated notable cytotoxicity against T47D breast cancer cell lines, with an IC50 value of 4.77 ± 1.61 μM, which means that it was over three times more potent than cisplatin (IC50 = 16.3 ± 3.9 μM) .
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PMC11787651
More than 150 histone peptides were identified in each replicate sample by each method.
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PMC11637284
In the second mutant, termed TAC60 R181E/E189R, the opposite charges were switched (Fig 6C, left), and in the third mutant, termed TAC60-E189R, E189 was switched to R resulting in a p166-TAC60 interacting kinked α-helix that contains two positive charges (Fig 6D, left).
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PMC8345486
The in-depth SAR analysis showed that the presence of nucleoside qualified (Cr derivatives), enhanced (Fe derivatives), or differentiated (Co derivatives) the cytotoxicity of these compounds.
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PMC10968586
In fact, treatment of MCF-7 cells with the mentioned OLE concentration for 48 and 72 h reduced histone deacetylase 2 (HDAC2) and HDAC3 gene transcription in a time-dependent manner , and downregulated oncomiRs miR-21 and miR-155 .
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PMC11612508
Because charged particles reject one another and thwart the desire to combine, a suspension is more likely to remain stable the higher the zeta potential.
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PMC11200978
Based on the promising results, next-step studies will focus on investigations using 3-dimensional tissue engineered lung cancer tumor models and in vivo models to further validate the benefit of combinatorial treatment.
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PMC11740508
All experiments except for G used at least triplicate samples, performed at least twice Talazoparib plus decitabine treatment potentiates cumulative DNA damage in HRR deficient cells.
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