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PMC11718109
Untagged synapsin and VMAT2-Flag were revealed by immunofluorescence.
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PMC8956657
D Crystal structure of HKU5 ORF4b bound to IMPα2 at 2.2 Å resolution (see Supplementary Table 11 for data collection and refinement statistics) and a comparison of MERS ORF4b bound to IMPα2 as per Fig. 1E.
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PMC9429973
Intraabdominal lymph node biopsy showed a diffuse involvement by HCL clonal B-cells (CD20+/CD10-/CD25+/CD5-/Annexin A+).
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PMC11055323
The enhanced onco-fusion condensates remodel H3K27ac by excluding HDACs complexes, which resulting in aberrant activation of embryonic developmental genes H3K27ac deposition can be targeted pharmacologically.
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PMC9429973
Results: The data include 31 patients enrolled by 15 September 2021, with a data cutoff of 2 December 2021: 4 patients in the DEP at dose level 1 (CPX-351 20 units/m on Days 1 and 3 + VEN 400 mg on Days 2 to 21 of each cycle), 7 patients in the DEP at dose level 2 (CPX-351 40 units/m + VEN 400 mg), and a total of 20 patients in the DEP and EP at dose level 1b (CPX-351 30 units/m + VEN 400 mg), which was established as the recommended phase 2 dose.
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PMC11045125
C. Stable cell lines derived from Donor 2 ΔEBNA2 EBV plus Myc tumors (right panel), or the EBV-positive Akata Burkitt cell line (left panel) were treated with or without IL7 for 30 minutes and the level of Y694-phosphorylated STAT5 was examined by immunoblot.
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PMC11753949
Neurons were fixed with 4% PFA, 4% sucrose, 1mM MgCl2 and 0.1mM CaCl2 in PBS.
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PMC11469524
To further characterize the crosstalk from p38 to MEK/ERK and to investigate more general consequences on overall signaling, a systematic proteomic analysis was performed.
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PMC7823217
Integration of vascular networks within bioprinted constructs would be a closer step towards the development of physiologically relevant engineered cancer tissues.
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PMC11621565
Representative image of triplicate wells.
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PMC7136814
Accordingly, a dose-dependent increase in Noggin mRNA levels for both cell lines was observed (Supplementary Figures and ).
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PMC10798140
It has been described as a potent selective, and permanent EGFR inhibitor.
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PMC11746948
All cells were cultured at 37 °C in a humidified incubator with 5% CO2 and were routinely tested and confirmed to be negative for mycoplasma.
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PMC11087055
White boxes showed enlarged areas. (
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PMC11683240
The source of α1AT was the commercially available drug Prolastin purchased from Grifols.
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PMC11506670
The most commonly used CRC cell lines, on the other hand, have variable background mutations in either KRAS, PIK3CA, or BRAF that may confound the interpretation of the phenotypes observed.
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PMC8557138
The hypoxic microenvironment of the tumor promotes the malignant cells to dedifferentiate and express endothelial cell markers such as von Willebrand factor (vWf), vascular endothelial-cadherin, CD31, laminin 5 γ2-chain, and EphA2 resulting in the formation of ‘endothelial cell-like cells’ (Dunleavey and Dudley 2012).
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PMC11568601
was added to each well after incubating with TGT for 24 h. The absorbance value was determined via a microplate reader (BioTek, Winooski, USA) at 450 nm after incubation at 37 ℃ for 1.5 h. Osteosarcoma cells were seeded into 6-well plates (5 × 10 cells/well) and incubated overnight until completely adherent to the wall.
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PMC11676674
This investigation will serve as preliminary research to establish the safety profile of this plant.
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PMC11470999
To analyze the mechanism of CIP2A downregulation, we first assessed the effect of PF on CIP2A mRNA levels.
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PMC7022782
Cells were seeded on 96-well plates (2.0 × 10 cells in 200 μL of CM/well) and incubated at 37 °C and 5% CO2 for 24 h to reach subconfluence growth condition.
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PMC9429973
Image: Summary/Conclusion: This practical and usable scoring system we developed can be supported also by new parameters.
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PMC11756937
The cell number was in the range of 1 × 10–2 × 10 per freezing vial.
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PMC9429973
Hematopoietic stem cell implantation time and recovery of white blood cells (WBC) and platelet (PLT)，implantable syndrome and Infectious fever were observed until day +60.
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PMC9429973
of Hematology, Leiden University Medical Center, Leiden; Dept.
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PMC6102174
Previous investigation revealed the liver protective effects of S. mileensis and the active constituents, e.g. sweroside, swertisin, and oleanolic acid, whereas the anti-HBV active constituent is still unclear.
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PMC9429973
The time until transformation lasted between 6 and 42 months, measured from treatment initiation.
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PMC11653533
A study proved that aqueous and ethanolic extracts of F. benghalensis roots showed antimicrobial activity against S. aureus, E. coli, and Klebsiella pneumonia, since 75 mg/ml of both extracts zone of inhibition was 14 mm, 12 mm, 14 mm, and 30 mm, 24 mm, 22 mm respectively, in comprise of 10 mcg/disc standard ampicillin, which zone of inhibition was 40 mm, 35 mm, 30 mm respectively (Murti and Kumar, 2011).
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PMC9479186
Staining working solution (Beyotime, Shanghai, Cat.
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PMC11420784
The membranes were incubated with the secondary antibody.
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PMC11769522
In addition, keratinocytes play a critical role in the cutaneous immune system, particularly in inflammatory skin diseases, including atopic dermatitis (AD) .
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PMC11487720
E COS7 cells were treated with UV (480 mJ/cm) and then cultured at 4 or 37℃ for 90 min, or 4 °C for 90 min without UV exposure.
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PMC9429973
There is a need for new treatment options for ALL patients.
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PMC11763126
G H&E staining assessing metastasis levels in lung tissues.
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PMC9429973
The role of tumor hypoxia in DLBCL remains unclear.
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PMC11434983
The detection of EGFR phosphorylation was performed with the use of a chemiluminescent detection system (ECL kit, Amersham, Uppsala, Sweden) according to the manufacturer’s instructions.
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PMC11612315
Calcium increases were elicited by CAP (100 nM) in the presence of GLP-1 analogs (100 nM each), GLP-1(7–36) (b), exendin-4 (c), liraglutide (d), or exendin 9–39 (Exe 9–39) (e) (mean ± S.E.M.).
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PMC9681981
The mean expression of etx gene in the experimental group harvested at 2 h, and 5 h after exposure was significantly different from the mean expression level at 0 h. The highest level of gene expression was observed in the experimental group at 2h; however, the difference between the intervals of 2 h and 5 h was not statistically significant (Table 3).
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PMC8662250
CBD caused a parallel inhibition of interleukin 1 beta (IL‐1β), IL‐6, tumor necrosis factor alpha (TNF‐α), and IL‐18 by enzyme‐linked immunosorbent assay (ELISA) assay.
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PMC5854676
The bands appearing at 1180 and 1125 cm correspond to twisted vibrations in C-H. A peak appearing at 450 cm can be attributed to Mg.
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PMC9844987
We tested both the association between the genotypes of common genetic variants (MAF ≥10%) and the expression of promoters (promoter eQTL, prQTLs) and decomposed promoters (decomposed promoter eQTL, dprQTLs), as well as their association with the contribution of to the overall expression of the encompassing (non-decomposed) promoter (fraction eQTL, frQTL).
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PMC11753435
Inspired by the groundbreaking work of OpenAI to generate photorealistic images from natural language descriptions via contrastive language-image pretraining (CLIP) (25), we first leverage the ESM-2 pLM to generate distinct but naturalistic peptide candidates by applying Gaussian noise to the embeddings of bona fide peptide binder sequences (19).
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PMC6901583
was utilized to calculate the data of a minimum of three independent experiments.
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PMC10582049
CAF population in indolent and aggressive LUADs. (
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PMC11607764
A tumor patient’s prognosis is usually assessed by survival time, including cancer-specific survival, overall survival (OS), disease-free survival (DFS), or relative survival.
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PMC5963610
However, proliferation and apoptosis were not modified (Supplementary Figure 6A and 6B).
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PMC11206502
Therefore, autophagy induction is a promising therapeutic approach .
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PMC10135767
Calcium signaling regulates several lymphocyte processes, including lymphocyte development, T cell and B cell activation, allergy, gene transcription, and effector functions .
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PMC10728200
The transfected cells were screened by puromycin (2 mg/mL) (ST551, Beyotime, Beijing, China) to establish a stably expressing cell line (Fig. S1).
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PMC10551595
After 48 h, cell viability was assessed using MTT assay.
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PMC11422150
Human amnion-derived mesenchymal stem cells (hAMSCs) are an attractive alternative source, as they are readily obtained from the placenta and are abundant in the amnion.
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PMC6379402
In these plots, genes from the same functional domain have the same color (see Methods) Illustration of iCell.
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PMC11499381
We also investigated whether fusion orientation influenced the regulation of the CLR/RAMP1 complexes following ligand stimulation; the CTR/RAMP1 complex was not investigated as it does not show ligand-dependent internalization .
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PMC8584666
In this study, GPI-80 cDNA was fused to a FLAG tag sequence, which was further fused to a signal peptide sequence.
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PMC11751675
The study utilized multiple linear regression (MLR) and self-organizing maps (SOM) as predictive modeling tools.
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PMC9429973
The current classification relies solely on clinical features and does not explain the heterogeneity that exists within each of these conditions.
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PMC11759543
Proteins were extracted after adding the doses of doxorubicin and vorinostat for another 24 h. Protein expression was analyzed by Western blot.
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PMC11087766
These complementation results are in agreement with spot titer results (Fig. 4D), indicating that this phenotype is specific and not due to off-target or polar effects on cotranscribed genes.
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PMC11476837
NRF2 gene and protein expression remained unchanged; however, we noted the down-regulation of KEAP1 protein upon ML-385 treatment.
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PMC11201989
Aside from its immune response functions, PD-L1 has also been shown to exert other roles in a variety of tumor cell types.
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PMC9429973
T cell phenotype was identified by multicolor flow cytometry assessing CD3, CD4, CD8, HLADR and PD1.
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PMC11766350
While useful in improving manufacturing characteristics, it does result in extra genetic material being included in the gene therapy going into the patient.
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PMC11762280
Statistical analysis of average optical density of ZBP1 positive staining was shown (n = 12).
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PMC11089031
D The statistical result of IHC.
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PMC11098378
To identify captured proteins, a lane of the gel above the unmodified IpaH4-UBAIT band was excised and proteins were digested in-gel with trypsin and run on a Q Exactive MS platform at the University of Texas Southwestern Medical Center Proteomics Core.
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PMC9841531
Interestingly, the concentration-effect curves of compounds 24 (Figure 11A), 30 (Figure 11B), and 31 formed a plateau below 100%, as indicated by reference ABCB1 inhibitor cyclosporine A (34).
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PMC10778532
WT VHL cells not transfected or transfected with siCt had a low expression of ZHX2.
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PMC9429973
receiving Axicabtagene ciloleucel (n=194) or Tisagenlecleucel (n=122) for R/R LBCL in a real-world setting.
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PMC9429973
Pts received randomized treatment along with CS (prednisone or equivalent) ± CNI for 24 weeks.
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PMC11612315
Furthermore, peripheral nerve injury leads to neuropathic pain, and the spared nerve injury (SNI) model in mice induces persistent heat hyperalgesia.
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PMC10142392
Nanoformulations using multi-arm amphiphilic polymers help solve these RES-based elimination problems by modulating the density of the nanoparticle corona and facilitating the introduction of functional groups for active transport and drug release in response to stimuli.
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PMC9429973
Additionally, compared to patients with regular hospital visits, patients with irregular hospital visits had a higher proportion of international staging system (ISS) stage III classification, time to diagnosis is longer and underwent transplantation less often.
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PMC11658074
AT-EVs combined with APN have anti-inflammatory effects, which may also have therapeutic effects on other inflammatory diseases, such as skin fibrosis and scarring.
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PMC9429973
The homocysteine ​​assay was done by an enzymatic technique.
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PMC9884169
All results were obtained from three independent experiments performed in triplicate.
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PMC11627398
Zhong et al. found that high concentrations of copper could induce liver lipotoxicity by enhancing Nrf2 transcriptional activation via MTF1 activation .
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PMC11092382
Its mechanism of action involves targeting the transient receptor potential ion channel (TRPV1) pathway.
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PMC11473843
The list of shRNA sequences used are reported in the Reagents Table.
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PMC10758402
For in-vivo experiments, DMF was dissolved in 100% DMSO or 0.8% methyl cellulose at 50mg/mL diluted at indicated dilutions before use.
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PMC11594074
DNA methylation is a process occurring across all major groups of living organisms, including plants, animals, fungi, and bacteria; however, it does not always serve the same purposes.
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PMC11075223
Owing to the good medicinal properties of Cimicifugae Rhizoma, the application for this herb has gradually increased in recent decades .
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PMC11747949
Once tumors reached palpable size, we randomized them into two treatment groups (n = 10 per group).
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PMC11377827
Samples were incubated on ice for 10 min and diluted 1:1 with ChIP dilution buffer (20 mM Tris-HCl (pH 8.1), 1% (v/v) Triton X-100, 2 mM EDTA and 150 mM NaCl).
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PMC5363531
From this plasmid was cut the region of TS promoter by BAM-HI/HIND III and subsequently cloned in pGL4.14[luc2/Hygro] linearized with BGL II/HIND III generating plasmid pGL4-TS-Prom-1191 + 176.
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PMC9031474
In general, there are certain modifications of polygodial (2) leading to a loss or an increase in cytotoxicity (Figure 16).
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PMC9429973
In a 3 + 3 escalation phase, up to 18 pts would receive iada at doses of 75 to 150 ug, orally, on 5 days ON -2 days OFF schedule, with continuous gilteritinib PO, at 120 mg/day.
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PMC11785489
Most strikingly, CV4 appeared to capture TCR sequence differences between naive and memory T cells (Figures 2H and S3L).
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PMC11787381
Blank liposomes (i.e. without bambuterol) and bambuterol-loaded liposomes (BBT-loaded liposomes) were prepared according to the adapted method of the thin film hydration, followed by extrusion with a mini-extruder.
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PMC11173119
During the 14–19 days of culture, the cell suspension was collected from embryoid bodies containing monocyte-like cells, centrifuged at 300× g for 5 min, and seeded onto chambered coverglass 8-well plates pretreated with 0.1% gelatin for immunofluorescence staining.
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PMC11656657
3Long-term tumor control of CAR.GD2 T-cells in an in vitro co-culture assay of RMS and OS models under "stressed" conditions.
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PMC9031474
W. Feng et al. used Fomes officinalis as a source of drimane sesquiterpenoids (Figure 12) .
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PMC11767817
This process prevents excessive accumulation of reactive oxygen species, thereby protecting cancer cells from apoptosis, autophagy, or senescence .
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PMC10938336
Their significant connectivity in the PPI network and the convergence of compounds targeting these hub genes highlight their potential roles in influencing cancer progression.
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PMC11782508
For instance, bacteriocins, ribosomally synthesized antimicrobial peptides, are promising in cancer treatment as they can inhibit tumor development through mechanisms such as inducing apoptosis, blocking the cell cycle, and inhibiting cell metastasis.
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PMC9429973
Methods: We retrospectively compared immune reconstitution data of 339 recipients of matched-unrelated donor (MUD) HCT with either ATG (n=304) or PTCy (n=35) as T cell depletion via conventional analysis on the cohort level and for its individual heterogeneity via time-series clustering.
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PMC7570809
The results obtained indicate that RGDechi15D is not able to inhibit K562 adhesion neither on fibronectin nor that of the α5β1 specific antibody; in this experiment the RGDechi peptide was used as a control to recognize αvβ3 integrin thus proving the validity of experimental data (Figure 3A,B).
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PMC9587866
Sorbifolin has a downregulatory effect on the E2F5 transcription factor that drives the continuous cell cycle in EWS cells (Schwentner et al., 2015) and also on the STEAP1 (Grunewald et al., 2012) gene.
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PMC4395774
Figure S2.
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PMC10243817
Interestingly, we found a negative correlation between levels of mRNA for MEX3B and COL1A1, COL4A1, COL4A2, and COL5A1, whereas TGFBR3 mRNA was positively correlated with these collagens in epithelial cells in patients with eosinophilic CRSwNP (Figure 8, F–M).
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PMC9429973
Methods: Patients with newly diagnosed MCL between August 2002 and April 2015 and followed through 2021 were identified from the Mayo Clinic/University of Iowa Molecular Epidemiology Resource (MER) prospective cohort study.
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