Datasets:
OTAR3088
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BioData-CellLine_annotated

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PMC9119314
IC50 values were determined using linear regression analysis (Microsoft Excel).
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PMC11525293
Supporting this hypothesis, we identified in silico a p53/p63-RE in the ACE2 gene and demonstrated that, in conditions mimicking the well-known COVID-19-associated cytokine storm, p63 does indeed bind to this element.
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PMC11461874
Then the embryos were placed in a line in the gap of an electrode (LF501PT1-10, BEX, Tokyo, Japan) filled with 0.1% PVA-Opti-MEM I (total 5 µL in volume) containing Cas9 protein and sgRNAs, and electroporation was performed using a CUY21EDIT II electroporator (BEX).
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PMC11615828
The readily releasable pool of synaptic vesicles in synapses needs to be replenished by synaptic vesicle transport along MTs, serving as a rate‐limiting mechanism for high‐frequency neurotransmission.
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PMC11705547
In addition, the small size and stability of the NPs increase the likelihood of accumulation at tumor sites, thereby improving systemic diffusion of of the drug cargo .
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PMC11247842
Lack of reproducibility of QTL identified for mastitis traits in AnimalQTLdb between different studies and breeds may be due to the complex nature of mastitis resistance (low heritability, effects of environment, variation in the phenotype definition), the segregation of different variants in different breeds, and potential genotype by environment interaction effects.
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PMC10932641
Therefore, the changes in expression levels and functions of these RNA types in different tumors suggest their potential use as biomarkers for cancer diagnosis (17) and as potential targets for cancer therapy (18,19).
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PMC10135767
The calcium signaling events triggered by the binding of integrin α4β7 to MAdCAM-1 under different flow shear stresses were described by the delay time, peak time, and peak calcium intensity.
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PMC10213199
TCMID 2.0 will further promote the modernization of TCM and facilitate the exploration of their underlying biological processes.
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PMC10772747
It provides a comprehensive understanding of the complex interactions between active compounds in natural ingredients and the biological targets involved in cancer development (Tang and Aittokallio, 2014).
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PMC9622879
Compared to the community with a prosumer-centric CEMS, the community with our proposed CEMS only has 78% of the daily energy cost.
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PMC11531735
HCC-VC; 3.
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PMC9429973
We then investigated whether c-MYC could be repressed by brequinar in DHL cells.
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PMC10165258
The IC50 values found in plates and in the microfluidic experiments were in very good agreement, as shown in Table 1 (see Table S1 for full results).
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PMC4485786
NKp30, NKp44, NKp46, DNAM-1, and CD161 transcripts were determined with specific primers in end-point PCR using 5´FAM-labeled reverse primers (primers and protocols can be obtained on request).
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PMC11323699
c, Histogram representing CD4 (blue), CD8 (green), and FOXP3 (pink) signal intensities at baseline (circle) and after NACT (triangle) in the CD47 and CD47.
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PMC9250505
p < 0.05, **p < 0.01, ***p < 0.001 .
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PMC9352806
Results indicated that BMS showed strong fat-lowering and lifespan-extension properties.
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PMC11088135
In addition, miR-376a-3p is associated with lymphatic metastasis in gliomas and attenuates glioma metastasis by negatively regulating KLF15 expression .
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PMC10547921
In conclusion, the study found that porcine STING uses asymmetrical conformations to bind CDNs.
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PMC4443654
accuracy; AUROC, area under the receiver operating characteristic curve; eig, eigenvector; MSE, mean-squared error; PCC, Pearson correlation coefficient; RMSE, root mean-squared error.
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PMC11786704
Low-magnification SEM, (B) High-magnification SEM and (C) TEM images of PC capsules. (
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PMC9429973
A drug combination study using tolinapant in R/R PTCL is being developed.
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PMC9429973
Group I patients who have coherent 6 α genes and groups II and III with 5 α globin genes.
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PMC10530622
For instance, a median plasma oxalate level of 9 μM (range 2.7–5.3 μM) was quantified in 167 stable kidney transplant recipients, median age 52 (18–81) years old, 37% of whom were female and 38% had live kidney donors.
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PMC11634027
In summary (Table S1), deletion of the D motif results in phenotypes consistent with reduced Ds activity across a range of activities whereas deletion of the A motif, and to a lesser extent the C motif, result in phenotypes consistent with increased Ds activity.
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PMC5363531
Comparable rates were observed with the sequence rD (apoptotic rate 10.3%), and a higher rate with the combination of PEM and dasatinib (16%).
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PMC11705630
Cells were observed under Leica Stellaris 5 confocal microscope.
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PMC11640419
The test substances were incubated with the cells at two concentrations, 0.5 and 1.0, for a period of six hours.
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PMC11770130
P < 0.05; ***P < 0.001; ns, not significant.
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PMC11792888
Relative protein expression of target proteins in A549 cells following R. junceus scorpion venom (IC50), etoposide (Eto, IC50), and combined treatment. (
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PMC11740399
12pt] $$ (\%)=}} 100 \%$$ To evaluate cell death, T24 and 5637 cells were seeded at a density of 3.0 × 10 cells per well in a 24-well plate for 24 h. Subsequently, these cells were treated with control, OXA, 3025@ML + OXA, and 3025@ML alone for 48 h. Cell death was quantified by trypan blue staining.
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PMC5941560
gzftp://ftp.ncbi.nlm.nih.gov/pub/clinvar/vcf_GRCh37/archive_1.0/2016/clinvar_20160802.vcf.gz).
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PMC11656048
Thus, the induction of ferroptosis is a promising strategy for suppressing cancer cells progression.
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PMC11655498
PAX5 interacts directly with Zta and inhibits Zta-mediated lytic gene expression (Raver et al., 2013).
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PMC9429973
RNAi-mediated silencing revealed a dose-dependent effect of Gata2 expression on leukemia cell fitness in vivo.
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PMC11782508
Azurin production by Pseudomonas aeruginosa strain 105. (
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PMC9429973
Consequently, modulators of the Notch pathway, such as γ-secretase inhibitors (GSI), would be expected to have clinical efficacy (Rao, Cancer Res 2009).
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PMC11766174
Specifically, the detection percentages decreased from 15% at the 1:5 dilution to 1.7% at the 1:50 dilution, 0.14% at the 1:500 dilution, 0.04% at the 1:5000 dilution, and 0.015% at the 1:50,000 dilution (Figure 2A,B).
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PMC9368503
Data points from dose response assays were used to fit a four-point non-linear regression curve via Graphpad Prism and the drug screen data were subjected to hierarchical clustering using Perseus software with Euclidean distance as the distance metric.
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PMC11767817
On the other hand, the BF2 counterpart exhibited similar activity under both normoxic and hypoxic conditions, with 3.31 µM and 2.58 µM after 24 h and 3.27 µM and 2.96 µM after 48 h, respectively .
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PMC5363531
REN cells showed high levels of both TS and SRC: dasatinib inhibited SRC activation and suppressed TS protein expression, starting from 100 nM dose, blocking the PEM-induced up regulation of TS protein levels.
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PMC11628904
All zebrafish experiments performed were approved by the University of Wisconsin—Madison Research Animals Resource Center under the Protocol M005405‐R02.
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PMC10788478
LGR6 expression was upregulated in spheroids compared to adherent cultures of A427 cells, suggesting that LGR6 participates in the acquisition of cancer stem cell properties.
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PMC7090062
a GIST-T1 and GIST-882 cells treated with single 3-MA, 3-MA, and miR-30a inhibitor or the negative control were exposed to imatinib, then the cell viability was measured by the CCK-8 assay.
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PMC9429973
One patient was non Severe aplastic anemia remaining 20 patient were severe aplastic anemia.
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PMC11754291
The x-axis displays different combinations of irradiance (mW/cm) and fluence (J/cm) for blue light, with the last combination representing UVA light at 15 mW/cm and 20 J/cm.
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PMC9503669
Nef lacks any known biochemical or enzymatic activities, functioning instead through interactions with a diverse range of host cell proteins at the plasma membrane, trans-Golgi network and other membranous sites.
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PMC11739484
P-value < 0.05.
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PMC11323699
populations.
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PMC11742047
The use of cannabis-derived compounds began over time, not for therapeutic purposes, but as drugs of abuse, since some of them are psychotropic substances that can interact with various neuronal functions, such as pain, concentration, and mood, due to their capacity to bind CB1 receptors.
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PMC7294030
Cells were treated with aurisin A (0, 1, 2, 4, 8, 16, 32 µM) for 24, 48 or 72 h. After the treatment, cells were fixed, aspirated and incubated with SRB dye (Sigma Aldrich, Germany) for 30 min at room temperature.
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PMC11555465
Therefore, the present experiment was designed to explore the role of T. gondii tachyzoite culture supernatant in bladder cancer 5637 cells.
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PMC11640419
Subsequently, the PBS was removed, 10 μL of lysis buffer (Cell Signaling Buffer and Detection Kit, Luminex, Austin, TX, USA) supplemented with 2 × protease and phosphatase inhibitors (Luminex, USA) was added, and the mixture was shaken for 30 s. A cocktail of fluorescence-encoded magnetic bead microspheres (MagPlex, Luminex, USA) was resuspended and treated with ultrasound.
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PMC9429973
It is very likely that associated diseases maintain a chronic inflammatory state, which is added to that of chronic myeloid neoplasia, mainly when it is refractory to treatment.
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PMC10955424
Abbreviations: As denotes OC ascites, Cr denotes cirrhosis ascites; N/A, not applicable; NR not relevant.
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PMC10443665
CCRF-CEM, CCRF-CEM/R cells (2 × 10 cells/mL) were seeded in 6 wells plates.
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PMC11670407
P < 0.05, **P < 0.01 vs. the corresponding control Cisplatin, but not doxorubicin or methotrexate, upregulated OTULIN expression in osteosarcoma.
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PMC9672323
However, due to the suppressive properties of dexamethasone especially on the anti-tumor T-cell responses, identifying a competent alternative seems necessary.
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PMC6450504
Figure 5(d) shows that significant P-gp downregulation (p < .001) with 0.5%PEIPOS and 100 nM siMDR1 was achieved in serum-complete media in a 4 + 44 h treatment scheme, which was very similar to the downregulation obtained by bPEI-DOPE micelles used as positive controls.
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PMC10898159
Currently, seven drugs targeting KIT mutations have already been approved by the FDA for the treatment of advanced-stage GIST (imatinib, sunitinib, regorafenib, ripretinib, avapritinib, larotrectinib and entrectinib), all of which are TKIs .
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PMC6337547
The main polyphenols in Chinese Salvia species are phenolic acids and flavonoids, which exhibit anti-oxygenation, anti-ischemia-reperfusion injury, anti-thrombosis, anti-tumour, and other therapeutic effects.
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PMC9429973
Safety endpoints included incidences of adverse events (AEs).
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PMC11803918
Through a freeze–thaw membrane fusion method, we successfully loaded a photosensitizer into γδ-T exosomes using liposomes while preserving their antitumor functions.
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PMC11787381
Cœlanterazine 1H (Molecular Probes) was added at a final concentration of 5 μM. The BRET signal was measured using the Mithras LB 940 plate reader (Berthold Technologies) for 24 min (8 reads of 3 min).
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PMC11763111
Nonetheless, this approach may leave CAR-T cells vulnerable to immune rejection by NK cells due to the loss of self-recognition through HLA-I molecules .
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PMC11297139
Additionally, qRT-PCR was performed to demonstrate the transcriptional regulation of EWS/FLI1-bound genes by ARID1A, revealing a significant decrease in the expression of EWS/FLI1 target genes in the SK-N-MC KD cell line (Supplementary Fig. 12e).
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PMC11566417
The stem cell secretome can increase angiogenesis, which may promote the revascularization of damaged tissues, reducing the ischemia which can occur as the result of bacterial infection .
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PMC9918897
For the XN stock solution, 400 mL of a 50% aqueous alcohol mixture was prepared to ensure proper solubility of XN.
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PMC11454015
Importantly, when comparing the two independent CDH1 gRNAs to NTG there were 2882 shared genes (1436 upregulated only, 1407 downregulated only) that were differentially regulated.
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PMC7229095
With using CDM1, CDM2 and CDM3 as selection media, a mini-pool screening showed the mini-pool recovery per 96-well plate was nearly 10% with CDM1 while no clones grew with CDM3.
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PMC10671321
CMS are classified into pre, post-synaptic or synaptic depending on the specific location of the mutated protein.
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PMC9424261
F The relative protein level of GCLC, GSS, CBS, CTH, and SHMT2 are normalized according to the level of GAPDH calculated by ImageJ software.
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PMC6771295
p < 0.001 is indicated with (***), p < 0.01 with (**), and p < 0.05 with (*).
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PMC11802855
All procedures were performed according to the manufacturer’s instructions.
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PMC11755519
It was observed that SV-HUC cells acquired resistance to inhibition of proliferation by cell-to-cell contact under the influence of EVs secreted by TCCSUP cells.
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PMC10932641
Therefore, given the findings of this study that lncRNA GPRC5D-AS1 can inhibit the proliferation and invasion of 786-0, there is reason to believe that this lncRNA may act on certain components of the TME of RCC and exert an anti-cancer effect.
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PMC11791478
These results indicate that XB002, the zovodotin-based ADC, is more efficacious than the vedotin-based ADC in this model.
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PMC9268183
Whilst efforts need to focus on the prevention and/or cure of cancer, another important issue to tackle is the side effects of standard medical treatments, and investigation into how plants can contribute to the alleviation of the effects of antitumour therapies.
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PMC11704834
To date, the mechanisms by which EGFR-TKIs trigger apoptosis are yet to be fully delineated.
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PMC5833712
In this report we have focused on other aspects of ERβ function and activity as a ligand-activated transcription factor and growth inhibitor of tumor cells.
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PMC11705067
Docking results indicated that mitotane, adicicol and dihydrolipoic acid might be potential drug targets for FDX1 and DLAT.
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PMC9429973
Among age groups, the number of patients with >1 TCTH indications was:18-30 years:46; 31-40 years:50;41-50 years:31;51-60 years:24;+60 years:17.
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PMC9429973
Patients who had a positive biopsy, were diagnosed with TA-TMA or aHUS, or had received eculizumab following alloHCT were considered to have definite TA-TMA.
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PMC11612508
In vitro cell viability of L929 cell line incubated with (a) GO/CS/IO magnetic microspheres, (b) GO/CS/IO magnetic microspheres in the presence of magnetic field, (c) GO/CS/IO/TMZ magnetic microspheres, (d) GO/CS/IO/TMZ magnetic microspheres in the presence of magnetic field, for 24 h (SD ± 2%) and 48 h. Synthetic or adaptable microspheres have demonstrated potential in controlling drug release when an alternating magnetic field is applied.
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PMC8358006
In detail, we found that 643 out of 840 GSDs overlap with the TADs and 431 mark the anchors.
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PMC11687167
After lipid loading, TLR4 protein expression was reduced in PCSK9-silenced inflammatory cells, and NF-κB nuclear translocation was decreased, suggesting the downregulation of the proinflammatory TLR4/NF-κB pathway.
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PMC11055510
There was no significant difference in fluorescence activity between the mut ILRAP with miR-135a-3p inhibitor NC co-transfection group and the mut ILRAP with miR-135a-3p inhibitor co-transfection group (Fig. 6H). (
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PMC9429973
Richter transformation is a rare and aggressive complication of CLL, with little information in current literature regarding possible predictive factors.
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PMC11686380
Error bars indicate SD from 10 to 15 neurons; p < 0.05, p < 0.0001, *p < 0.05, and ****p < 0.0001 by one-way ANOVA with Tukey’s post hoc test (*, vs. control; , vs KD#1). (
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PMC5415764
Photos of protein bands were taken by a Molecular Imager ChemiDoc XRS (Bio-rad).
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PMC11705630
GLDC is most highly expressed in the liver and then in the kidney 37.
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PMC11119602
It would be interesting to validate the hypothetical interaction of TG2-S with LC3/other proteins in in vitro and in vivo studies.
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PMC10887351
Conversely, still in prostate cancer, in the absence of stress in vivo, β-ARs agonism accelerated tumor progression and metastases .
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PMC10870498
Finally, an enhanced chemiluminescence solution (Pierce; Thermo Fisher) was used for protein signal detection.
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PMC11739484
The quality and purity of the isolated RNA were evaluated using an Agilent Bioanalyzer (Santa Clara, CA, USA).
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PMC11265931
Data analysis was carried out using the CellQuest Pro program.
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PMC11402217
The Sham group received saline orally, while the MTX group served as a positive control with methotrexate.
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PMC9429973
Risk factors have been previously identified for this complication and high dose intravenous methotrexate (HDMTX) has been suggested as an effective strategy to prevent CNS lymphoma relapse (GELTAMO guidelines Haematologica 2017 and British guidelines BJAEM 2020).
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PMC9429973
M. Callejas Charavia, L. Castilla García, J. Aspa, P. García Ramírez, M. Argüello Marina, C. Martínez Vázquez Hematology, Hospital Príncipe de Asturias, Alcalá de Henares, Spain Background: Cutaneous B-cell lymphomas can be classified into two categories: primary cutaneous lymphomas (PCL) and secondary lymphomas.
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