Datasets:
OTAR3088
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BioData-CellLine_annotated

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PMC11352746
To prevent evaporation, add 150 mL of Sterile DPBS (Gibco, Grand Island, NY, USA, Cat. #
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PMC11411131
However, the molecular weight of this signal differed from that of the full-length protein, as confirmed by a mutant with a Cys substitution for Sec. (B) Expression of an artificial selenoprotein using several SECISs.
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PMC9429973
In total, 33 (28.4%) referred pts were found to have at least one actionable germline mutation.
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PMC11128598
In this study, we report, for the first time, that the combination of the antimalarial drug CQ with the HDACi LBH or with NHEJi produces a robust synergistic effect in breast, colon, glioblastoma and head and neck cancer cell lines.
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PMC11513011
In the apoptosis assay, DIB and DMSO were administered at a concentration of 0.01 μm each.
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PMC11650848
This task was chosen as it was considered most analogous to the cognitive processes showing differences in the WISC-IV.
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PMC10048572
This cell line was established in the mid-1970s from the peripheral blood of a 14-year-old boy with T-cell leukemia.
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PMC10932641
The animals were included in the study if the animal was successfully inoculated with RCC cells and were excluded if they died prematurely (preventing the collection of histological data).
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PMC11394112
U2932-Luc cells were initially found in the spleen, liver, and lungs starting in week 2 (Figure 3A,B, left panels).
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PMC11643491
This is particularly important in cancer therapies where the ability to selectively target and deliver drugs to malignant, more elastic cells could significantly improve therapeutic outcomes.
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PMC10969097
Lastly, Group 4 served as the control group, receiving only the vehicle.
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PMC11269792
Whether other miRNAs are involved in circAPP affecting Warburg effect of GIST and the related specific mechanism still needs to be further explored.
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PMC11723947
However, HP1α-deficiency in Tconv has no detectable impact on Treg programming (Fig. 2e) and does not affect all Treg functions.
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PMC9599726
GIST882 and GIST48 cells were seeded in 96-well plates (TPP Techno Plastic Products AG, Trasadingen, Switzerland) at a concentration of 10,000 cells/well supplemented with 100 μL of medium 72 h before drug treatments.
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PMC11144382
In addition, homozygous Crabp2 mice (C57BL/6N background) generated via CRISPR-Cas9-mediated deletion of exons 2–3 had heart abnormalities and decreased bone mineral content (International Mouse Phenotyping Consortium).
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PMC11594074
A hallmark of malignant cell invasion is the epithelial–mesenchymal transition (EMT), in which epithelial cells transition to a mesenchymal phenotype, characterized, for example, by the upregulation of vimentin and fibronectin .
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PMC5916734
Two reasons are known for the absence of biological activity in FIX: insufficient γ-carboxylation of its Gla domain and retention of propeptide in the secreted FIX molecule so that efficient processing of FIX propeptide by hostcell endogenous proteases belonging to the PACE/furin family becomes impossible .
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PMC10936243
Of course, we always try to do things that don’t create more work for ourselves.
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PMC9429973
While 18 elderly patients (30%) with a median age of 70 years (range 60-85 years) received the low intensity therapy (low doses of cytarabine, hypomethylation therapy and venetoclax containing regimens).
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PMC11172027
The use of 125 µg/mL NASeLM showed a significant reduction in mitochondrial activity of 78.2 ± 8.4% compared to the control (100.0 ± 10.8%; n = 3; p = 0.05), which was further reduced to 58.7 ± 6.2% at 200 µg/mL NASeLM (p < 0.01; n = 3).
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PMC10747160
For the purposes of completion, we performed a less intensive screen of Q-Grft to verify that the M78Q mutation did not alter the trend of Griffithsin increasing Raji DC-SIGN+ infectivity.
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PMC11637284
TAC40 and ATOM40 serve as positive and negative controls, respectively.
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PMC9920575
Therefore, in this work, the antiproliferative and apoptosis-inducing potential of the S. chinantlense extract was compared in the human cervical HeLa cancer cell line and the nontumorigenic HaCaT epithelial cell line.
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PMC9780037
Ionic liquids have demonstrated the ability to stabilize proteins during production, transport, and storage, making them of outstanding value in the utilization of proteins as therapeutic tools .
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PMC11705862
For example, microglia express SNAP-23 isoform, needed for their phagocytic function .
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PMC9398137
In accordance with the generally recognized molecular features of Burkitt lymphoma and in contrast to DLBCL, Burkitt lymphoma cell lines were either BCL2-negative or expressed low levels of BCL2 protein (Fig. 1B), possibly explaining their overall higher sensitivity to S63845 (14).
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PMC11700523
At 24 hours before transfection, 1×10 cells per well of a 24-well dish were plated in Opti-MEM (Thermo Fisher Scientific, Tokyo, Japan).
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PMC5025404
Thus, CHO-DG44-derived cell lines producing mAb were developed using two strategies, one based on individual clones and the other based on cell pools.
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PMC11095939
WB of Mecp2 and pRb in control and Mecp2 overexpression (OE) 3T3 cells released from SS-induced quiescence at the indicated time points. (
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PMC11727306
It has been shown that recent activation is necessary for the increased expression of macrophage galactose-type lectin-binding glycans on the cell surface of T-cells .
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PMC11754094
P = 0.1402 for PE3 + hMLH1dn and P = 0.0026 for PE3 + epegRNA compared to the original PE3 system.
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PMC11769522
To investigate cytokine production by different cytokine stimulators, CPEKs were seeded on 24-well plates (30,000 cells/well) and incubated with 30 ng/mL of canine recombinant IL-4, IL-13, an IL-4/IL-13 mixture, IFN-γ, TNF-α, and an IFN-γ/TNF-α mixture for 24 h. As our preliminary experiments showed an increase in cytokine concentrations in response to 30 ng/mL of the IFN-γ/TNF-α mixture compared to 10 ng/mL, and no significant differences between a 24-h and a 48-h incubation, we selected 30 ng/mL as the stimulus dosage, with 24 h of treatment.
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PMC9351137
The mask was converted in a selection to apply on remodeler signal which needed to quantify.
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PMC11591052
We observed a significant 20E-mediated induction of glycolysis and, especially, respiration in both cell lines (Figure 6, Figure 7 and Figure S4).
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PMC11413393
Previous reports have linked PRMT1 sensitivity to factors like MTAP loss, SRSF mutations and gene expression signatures enriched for interferon response and antiviral signaling.
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PMC9429973
These data may help inform bridging strategies for chimeric antigen receptor T-cell therapy.
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PMC9918897
The outstanding anticarcinogenic properties of XN, a substance belonging to the family of polyphenols, can be partly explained by its lipophilic antioxidant properties .
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PMC8557138
Hydrogel-based perfusable vascularized tissues help in modeling the in vitro processes better and enhances the efficiency of in vivo transplantation.
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PMC11489175
Besides, pharmacological or molecular inhibition enhances PD-L1 but also increases innate and adaptive immune responses 96.
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PMC11596967
In D. radiodurans, double-strand DNA breaks, the most lethal damage from IR, are repaired primarily through the homologous recombination (HR) pathway via extended synthesis-dependent strand annealing (ESDSA).
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PMC11474209
Numerous traditional water treatment methods, including coagulation, flocculation, sedimentation, and filtration, struggle to efficiently eliminate extracellular/dissolved cyanotoxins due to their fluctuating concentrations and types .
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PMC11743316
Despite its lack of specificity and sensitivity, the CA125 antigen has been associated with epithelial OC .
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PMC4685411
From the third iteration a numerical optimization of the response-surface was done.
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PMC9429973
Treatment-related adverse events have been mild (Grade 1 or 2) and resolved.
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PMC9429973
Results: For the audit, 80.4% of the requests were for FVL, 3.8% were for FII and 15.8% of the requests were for FVL and FII together.
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PMC9429973
Primary endpoints were overall (OS), progression-free (PFS) and event-free survival (EFS), defined as time from diagnosis to death, death or progression/relapse, progression/relapse or treatment discontinuation.
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PMC11473843
This is also in line with previous findings, which demonstrated that the inhibition of FAK in human xenograft models of lung cancer primarily yielded a cytostatic effect (Konstantinidou et al, 2013).
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PMC11775197
PPAR may serve as a tumor suppressor or a tumor-promoting factor, exerting antitumor or pro-tumor effects, respectively.
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PMC10809689
GLS and mTORC protein expression was determined by western blot technique and compared to β-actin as loading control.
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PMC11545868
Initiator caspases include caspase-8 and caspase-9 .
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PMC11756907
In this case, the use of ethanol as a solvent for the tested compounds (GO, rGO, and their derivatives) also reduced their anticancer effectiveness compared to the use of DMSO as a solvent.
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PMC11290772
Subsequently, the NK cells stimulation was performed following the datasheet of the AMMS NK Cell Culture Kit (AS01-1, Seafrom Biotechnology, Beijing, CN) and referenced the protocols in the previous studies .
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PMC11752740
The results are expressed as Mean ± SD, with statistical significance determined at P < 0.05.
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PMC7553912
In addition, our in vivo study showed that strong expression of OSMRβ was observed in the RTECs during renal crystal formation.
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PMC10454535
The dose of 5 μM PIN used in our study showed minimal effects on ROS production in RPMI 8226 cells, and treated cells were not saved by ROS inhibitor NAC (Figure 6).
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PMC9429973
W. Chawad, A. Laabichi, Y. Moussadik, Y. chhih, F. ibourk idrissi, A. taouch, S. el fari firdaous, H. talebi, H. hanani, S. belkhettab, M. bouaouad, N. mouatassim, H. khibri, W. ammouri, M. maamar, H. harmouche, Z. tazi mezalek, M. adnaoui internal Medecine and Clinical Hematology, Ibn Sina’s Hospital, Rabat, Morocco Background: Acquired Willebrand syndrome (AvWS) is a rare hemorrhagic syndrome, clinically and biologically identical to constitutional Willebrand syndrome (vWS).
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PMC9429973
Overall response rate was lower in R/R AML (37% versus 56%) including 13% CR, 8% CRi, 3% PR and 13% MLFS in the R/R AML group and 32% CR, 13% CRi and 13% MLFS in the ND AML group.
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PMC9429973
Expression of SAMHD1 was assessed using a double-immunostaining method (SAMHD1/CD68), an autostainer system (BenchMark Ultra, Ventana, Rotkreuz, Switzerland) and previously validated protocols.
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PMC11389534
UFMylation of PLAC8 at K103 helps maintain its stability and upregulates PD‐L1 expression, which promotes the proliferation of triple‐negative breast cancer (TNBC) cells, and suppresses the activity of T cells.
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PMC8097906
All cell lines were cultured in Dulbecco’s modified Eagle’s medium plus Ultraglutamine 1 (Lonza, Verviers, Belgium), with 10% fetal calf serum (PAN Biotech GmbH, Aidenbach, Germany) and 1% Antibiotic-Antimycotic-Solution (Gibco, Paisley, UK) and maintained at 37 °C and in a 5% CO2 atmosphere.
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PMC11216402
Correlation of GC cell line gene expression profiles with a healthy ENCODE lung fibroblast and a healthy stomach sample. (
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PMC9325715
Protein aggregation and fibrillation are the topics of numerous investigations.
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PMC10994876
β-Actin (ACTB) was utilized as a control.
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PMC11786156
CD34 + Ki-67 double immunohistochemical staining Anti-CD34 reacts with cytoplasmic membranes of vascular endothelial cells, and anti-Ki-67 reacts with the nuclei of proliferating cells, including tumor cells.
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PMC11627398
However, the function of SLC31A1, MTF1, LIAS and LIPT1 in septic shock remain unexplored.
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PMC11472639
There was a significant increase in the number of non-classical (HLA-DRCD14CD16) monocytes (+125 ± 89%), intermediate (HLA-DRCD14CD16) monocytes (+48 ± 26%), classical (HLA-DRCD14CD16) monocytes (+41 ± 24%), and effector (HLA-DRCD14CD32) monocytes (+41 ± 26%) following cycling exercise (F(2,14) ≥ 11.98, p ≤ 0.006, ηp ≥ 0.63).
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PMC10968586
This was not surprising, since in A549 cells, O2 supports Akt activations, promoting cell survival .
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PMC9429973
Aims: We propose to delete both CD33 and CLL-1 from hematopoietic stem cell grafts, thereby restricting these antigens to AML cells only to enable subsequent immunotherapy without risk of on-target off-tumor toxicities.
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PMC11786767
In contrast, only 20% of Ki67-miR-expressing cells progressed to telophase.
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PMC11549612
Gene silencing of BOLA1, BOLA2, and BOLA3 in 786-0 cells reduced cell growth and proliferation, enhancing wound healing capacity.
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PMC3681794
However, in the osteosarcoma cell lines HOS, U2OS and 791T stabilisation of HIF-1α in normoxia, with activation of the HIF-1 pathway, failed to induce drug resistance (Figure 3), suggesting that HIF-1 activation is not sufficient for cytotoxic drug resistance in these cells.
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PMC11394386
These findings corroborate previous studies reporting PTEN loss in up to 62% of CC cases, leading to sustained PI3K/AKT pathway activation .
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PMC7081114
Cell status was evaluated, and the medium replaced every 3 d. At the end of the culture period, the cells were washed with phosphate-buffered saline (PBS) and fixed with 4% paraformaldehyde for 30–60 min.
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PMC10125312
For cytotoxicity assays, 2 × 10 cells were seeded in 24-well plates (polystyrene clear flat bottom, Nunc Microwell, ThermoFisher Scientific) and allowed to grow for 3 days.
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PMC11745823
RIT1 overexpression enhanced colony formation and histogram analysis, n = 5. (
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PMC11530949
The face-centered cubic of Ag metal and the well-crystalline nature of monoclinic CuO were disclosed by XRD patterns, and the coating compositions were verified by EDX spectra (44).
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PMC9429973
Vacuoles in pocked RBC are generally considered as remnants of organelles in erythroblasts.
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PMC11528603
Among apoptosis regulators, BAK plays an important role in the intrinsic pathway, which auto-oligomerizes or co-oligomerizes with BAX to form pores on mitochondrial membrane leading to the decrease of mitochondrial membrane integrity.
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PMC10197932
Finally, we analyzed mitochondrial membrane potential, expression of anti-apoptotic Mcl-1, ROS production, and GSH content after US treatments in healthy lymphocytes and leukemia cells.
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PMC9429973
Pts included were adult (≥18 years), ECOG PS ≤ 3, with adequate renal and hepatic function.
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PMC11634027
Ds, Fj, and in some cases Fat are expressed in gradients across tissues where they function, and their differential expression and binding interactions leads to polarized membrane localization of Ds and Fat (Ambegaonkar et al., 2012; Brittle et al., 2012; Cho and Irvine, 2004; Clark et al., 1995; Ma et al., 2003; Matakatsu and Blair, 2004; Strutt and Strutt, 2002; Villano and Katz, 1995).
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PMC10607604
Coverslips were mounted and images were taken with a Zeiss Imager M2 and a PlanApochromat 40x/1.3 DIC (oil) and 63x/1.4 (oil) objective (Zeiss) with apotome.
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PMC8097906
Mean ± SD, unpaired t-test, n = 3, ** P < 0.01, * P < 0.05.
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PMC11001582
n = 3 mice per genotype, one-way ANOVA, Bonferroni’s multiple comparison.
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PMC11144200
In addition, early research has shown that adoptive immunotherapy plus liposomal DOX can increase the overall anticancer effect .
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PMC9926039
The human lung cancer cells (cell line A549) were obtained from the Pasteur Institute of Iran (Tehran, Iran).
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PMC10759659
P < 0.05, ** P < 0.01, *** P < 0.001) ARID1A loss-of-function mutations and copy number deletions correlated with ARID1A deficiency and were associated with worse overall survival in HBV-related HCC.
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PMC9219615
Three independent measurements were evaluated for all experimental and control treatments.
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PMC11464982
The cell proliferation index observed for the treated animals was not statistically different from the negative control values.
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PMC11683240
Values of median are given as x-fold of the untreated control (Con), mean ± SEM (n = 9 values from three independent experiments).
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PMC11359735
The single ion monitoring (SIM) method for GC-MS analysis confirmed the presence of the myo-inositol component in CSP.
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PMC11515150
Expression of CD5 in normal matural T cell. (
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PMC9429973
Spike specific CD4+ T cell responses, defined by activation markers (CD137 and CD154), were confirmed in 91% of the seronegative patients at two weeks after initial vaccination.
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PMC4839679
GO Biological Processes enriched by genes upregulated upon PBRM1 reexpression. (
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PMC7504302
Accordingly, most of the MPM-specific GEM models, if not all, developed to date have focused on introducing these specific genetic aberrations of the human disease.
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PMC11534035
PAI1 expression is impacted by treating A431 and CAL39 cells with GPER1 agonist G1 and antagonist G36.
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PMC11750165
Proteins samples for the Co-IP assay were prepared as follows.
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PMC11805741
HPLC-DAD chromatography, UV-visible spectroscopy, and LC/ESI-MS-MS spectrometry were used to characterize the extracted pigment.
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PMC11377827
In all cases, VHL loss or inhibition leads to HIF-α stabilisation, even when oxygen levels are abundant.
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PMC9429973
The most frequent AEs leading to discontinuation were increased ALT (overall, 4.9%; year 1, 4.5%) with bosutinib vs thrombocytopenia (overall, 1.5%; year 1, 1.5%) with imatinib.
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