Datasets:
OTAR3088
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BioData-CellLine_annotated

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PMC6379402
GDVD is a distance in [0, 1), such that a distance equal to 0 means that the two GDVs are identical.
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PMC11790599
This study focused on the in vitro anti-breast cancer evaluation of TSL, providing initial insights into its pharmacological properties.
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PMC11185260
On day 67 (ie, 32 days after the last treatment), the average volume of tumors from mice that received both radiation and scL-SMARCB1 treatment increased by 2.3-fold from their initial size, whereas the average volume of tumors treated with radiation alone increased by 10.5-fold from their initial size.
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PMC9812014
Aporphinoid alkaloids (Glaucine fumarate, N-methyllaurotetanine, and isoboldine-HCl) have also been reported to have anti-PV activities.
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PMC8557138
For example, Kim et al. constructed a PDMS-based perfusable microvascular network in fibrin bioink consisting of heterogenous cell types including HUVEC, lung fibroblasts, pericytes, and glioblastoma cell line U87MG.
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PMC9429973
There is a need for new treatment options for CLL patients.
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PMC11724582
The platform used in the GSE193258 dataset was GPL20301, which was analyzed via Illumina’s “HiSeq 4000” chip.
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PMC10048572
In the second step, only those lesions absent in the parental clone were analyzed.
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PMC11683240
Effect of α1AT on binding of PT in CHO-K1 cells.
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PMC11696576
In all cases, this small substituent resulted in reduction of the inhibitory potency on cPLA2α.
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PMC11435360
Bladder images were acquired using the GE system 3D steady-state free precession imaging sequence and fast imaging employing steady-state acquisition (FIESTA), and T2/T1 weighted images were produced.
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PMC11448304
Fig. 1Radioresistant A549 induction and validation.
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PMC11352746
There are a variety of techniques to support neurite outgrowth findings, and the most used ones are immunocytochemistry, cell viability assays, and western blots.
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PMC9429973
The vast majority of the patients were Hispanic (58%), followed by Asian (16%), Black (11%) and White (11%).
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PMC11650848
Moreover, there is growing evidence of alternative ZFP57 isoforms in multiple tissues .
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PMC11075223
The total pain rate of the C. foetida group was vastly lower than hormone groups, demonstrating analgesic effect in C. foetida .
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PMC6312945
BEL-7404 and MHCC97-L cell culture conditions were 37°C constant temperature, pH 6.8–7.4, and 5% CO2.
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PMC11548041
Indeed, EpCAM has been targeted for delivery of nanotherapeutics and immunotherapies such as chimeric antigen receptor (CAR) T-cell therapy and antibodydrug conjugates .
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PMC11754291
In contrast, the highest intensity (50 mW/cm, 50 J/cm) led to significant reductions in metabolic activity, highlighting the importance of carefully calibrating light parameters to harness the therapeutic potential of photobiomodulation (PBM) without causing harm.
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PMC9429973
Methods: Peripheral blood samples from 71 patients treated with venetoclax-rituximab or first line venetoclax-obinutuzumab combination were collected from 11 Hungarian oncohematological centres.
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PMC11098378
Cells were lysed using an Emulsiflex C5 (Avestin) in buffer containing 50 mM Tris-base, 500 mM NaCl, 10 mM imidazole, 1 mM PMSF, 0.5 mM TCEP, and SIGMAFAST Protease Inhibitor Cocktail Tablets at pH 7.4.
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PMC4685407
Using the CRISPR-Cas9 system without homologous regions, we performed knockouts of de novo DNA methyltransferase genes in CHO cells.
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PMC7351993
The differentiation of 3T3-L1 cells into adipocyte-like cells was based on the method reported by Rubin et al. Briefly, 3 × 10 cells in 10 mL of culture medium were seeded on the culture dishes (100 mm in diameter) 4 days prior to stimulation for the differentiation.
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PMC11767725
Overview : oMetS comprises central obesity, hypertension, dyslipidemia, and insulin resistance.oThese interrelated conditions collectively increase the risk of cardiovascular diseases, T2DM, and systemic complications.
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PMC4443654
TAD boundaries were examined over 40-kb bins over the 1 Mb flanking each boundary; compartment boundaries were examined over 100-kb bins over 3 Mb. (
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PMC11711345
The canonical SMILES was applied as the input data.
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PMC5839394
SKBR3 cells were seeded in 12 well culture plates with a cell density of 1 × 10 cells/well.
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PMC6450504
Tumor growth inhibition was compared between the groups until day 18, where the survival rate of non-siRNA-treated groups and control started decreasing (Figure 6(b)).
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PMC11342785
Cells were stimulated with isoprenaline and imaged for 135 min.
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PMC11529598
C. mRNA expression of TP53INP1 was measured by qRT-PCR in miR-3154 sponge U251 or miR-3154 sponge A172 and control cells. *
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PMC11672142
The log β value was determined to be 11.1, and the pH 7.4 relative log β value was determined to be 25.9.
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PMC6934009
The cytotoxicity effect of wogonin on A549 and A427 lung cancer and BEAS-2B cells was assessed by MTT assay.
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PMC8524093
Vertical transmission was observed all over the pregnancy stages, but the effects of CHIKV infection in neonates are diverse, varying from asymptomatic to severe, in which myocarditis and/or meningoencephalitis are the most relevant signs of severity (Cardona-Correa et al., 2017).
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PMC8557138
Contrastingly, there was absence of these genes in HBL cultures except the ANGPTL4.
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PMC11098378
This family includes chikungunya virus, the second-most prevalent arbovirus infecting humans worldwide .
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PMC11740907
The samples were then dried for 20 min.
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PMC11128598
Synergistic effect of chloroquine and Panobinostat in the different cancer cell lines.
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PMC10899471
The miRNA profiling data indicated that miR-939 was one of the most upregulated miRNAs in responder, compared with non-responder.
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PMC7185206
Combination PD-L1 and ADAM10/ADAM17 immunohistochemistry as well as serum sPD-L1 measurement may further improve therapeutic decision-making.
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PMC10998613
The distribution of fc values for CXCR4 had a median value of 0.18 (mean fc = 0.22±0.17) in COS-7 cells, consistent with simple dimerization.
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PMC11699178
Then, 50 μL of the mixture was transferred to each well of a pre-chilled 96-well tissue culture plate and incubated at 37 °C for at least 1 h to allow the matrix solution to solidify.
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PMC11610461
Color development was achieved by staining with DAB (Yeasen, Shanghai, China) for 5 min and re-staining with hematoxylin (Servicebio, Wuhan, China) for 1 min.
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PMC11740573
strains of EC (N = 5), EF (N = 5), and GBS (N = 5) at a turbidity of 0.5 on the McFarland scale (10 c.f.u/ml).
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PMC11188874
Underutilization of this abundant pool of intracellular proteins in the context of TCR–MHC-I interactions offers an untapped resource that holds the promise to generate potent antitumor responses.
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PMC9429973
Since the diagnosis of CM-TMA usually takes several days to make, we speculate that patients with rapidly deteriorating organ function or with early demise might not reach diagnosis and therapy.
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PMC6181431
We also performed in vitro functional assays on PBRM1 in RCC cell lines.
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PMC11756937
To ensure iPSC reliability and reproducibility, several quality control measures were applied to each reprogrammed cell line (Table 1).
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PMC7868205
Conferring to the results of the present study and the supportive conclusions of previously published reports, the AgNPs synthesized using R. apiculata could be considered to be nanotoxic against HEK-293 cells while comparing the IC50 values with those of HeLa cells.
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PMC11569208
Significantly downregulated (> 1 log2-fold change) gene expressions were processed by Gorilla to identify relevant gene ontology (GO) terms.
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PMC9429973
Summary/Conclusion: WES data from MF identified key CNVs events of oncogenesis and clonal evolution of MF that could serve as predictive markers in clinical practice.
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PMC11463018
Induction of apoptosis at 48 h by compounds SAHA, Filgotinib and 19 at 1 μM concentration in RPMI-8226 cell line by flow cytometry analysis.
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PMC8409415
Antitumor activity of cluster of differentiation 70‐antibody‐drug conjugate (CD70‐ADC) in vivo.
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PMC8526701
The cells were incubated for 48 h to study the knockdown efficiency of siRNA, and the same procedure was carried out using western blotting analysis.
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PMC6684588
In these experiments, mdx and wild-type mice were given unilateral injections of ACE-083 (100 µg) or vehicle (PBS) in the TA muscle twice weekly for 4 weeks. (
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PMC11687663
The present study aims the phytochemical profiling and bioactivity evaluation of A. helferiana.
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PMC11706776
Cell distribution was observed by flow cytometry on the Cytocell Platform at Nantes University (FACSymphony A5).
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PMC11575040
Overall, our findings underscore the therapeutic potential of targeting the LINC00094/miR-1270 axis for melanoma treatment, suggesting a promising avenue for future therapeutic interventions.
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PMC11012313
As shown in Figure 6A, LMP2A-positive LCL1 cells express significantly more HIF-1α than the LMP2A-negative ES1 lymphoblastoic cell line.
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PMC11472639
Calcein is membrane-impermeable, therefore, the amount of calcein released is proportional to the amount of cell lysis.
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PMC10850553
The upstream signaling cascade to release C5a from C5 in situ was next examined because a factor releasing C5a could be a therapeutic target considering the potential role of the C5a–C5AR1 axis as a node to trigger the rupture of IA lesions.
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PMC11472639
Daratumumab often fails to induce stringent complete responses, due in part to resistance to antibody-dependent cellular cytotoxicity (ADCC) exerted by natural killer (NK)-cells and monocytes.
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PMC11763533
In this context, bioluminescent probes are emerging as interesting alternatives for real- time pH estimation.
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PMC10571053
While resistance due to the expression of ABCG2 or P-gp was not seen with most FINs examined, this was not true for some erastin derivatives that had been modified to improve water solubility.
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PMC8526701
Cell viability was examined using an MTT (methylthiazolyl diphenyl-tetrazolium bromide) assay kit (Beyotime, Shanghai, China).
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PMC7351993
A better understanding of the dynamics and heterogeneity of metabolism requires an analytical tool to study the metabolic activity of single cells in a spatiotemporally resolved and non-perturbative manner, but conventional technologies are insufficient for meeting this requirement.
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PMC9429973
Pts received modakafusp alfa as a 1–4-hour IV infusion at 10 dose levels from 0.001–6 mg/kg at weekly (cycles 1–2 only; 0.001–0.75 mg/kg), every-2-week (0.2–0.3 mg/kg), every-3-week (Q3W; 0.4–0.75 mg/kg), or Q4W (0.75–6 mg/kg) dosing intervals; an expansion cohort was opened at 1.5 mg/kg Q4W after anti-myeloma activity was observed in 3/5 pts in the escalation cohort at that dose.
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PMC10237474
Thus, although the integration is random, the high integration efficiency of multiple copies of DNA fragments eliminates the need for screening and isolation of single cell clones that show high expression of the GOI.
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PMC6684588
Protein was eluted using a linear gradient of 0–100% 50 mM Tris and 2 M sodium chloride (pH 8.0).
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PMC11757230
However, no studies have investigated the effects of canine MSCs on the development of hematologic malignancies in dogs; thus, the risk of MSC-based therapy promoting the progression of intestinal lymphoma in CIE remains unknown.
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PMC11564322
The VGVAPG peptide increased the PCNA protein expression by 40.21%, while VVGPGA did not change PCNA protein expression, compared to the control (Fig. 6C).
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PMC11457557
Interestingly, chronic exposure to hyperglycemic environment has shown decreased expression of microRNA 320 (miR-320) but increased the expression of endothelin 1 (ET-1), vascular endothelial growth factor (VEGF), and fibronectin (FN) in human umbilical vein endothelial cells (HUVECs).
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PMC9727330
NNDAsp disturbs Caco-2 cell proliferation without affecting NCM-460 cell proliferation To test the cytotoxic effect of NNDAsp cell viability rate, MTT assay and relative produced LDH were achieved in Caco-2 and NCM-460 that pretreated with different concentrations of either Asp or NNDAsp.
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PMC11055443
Lipid droplets of adipogenic differentiation and calcium deposits of osteogenic differentiation of AD-MSCs at passage three were confirmed using ORO and AR staining, respectively (Figs. 2B and C).
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PMC6182045
While CHO derived rgp120 remained largely resistant to Endo H digest, the MGAT1 CHO expressed TZ97008 rgp120 was sensitive to Endo H digest, running as a ~60 kDa band post-digest digest (Figure 6C).
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PMC11609529
Disruption of condensate formation impacted target gene expression in engineered 293T cells that express mEGFP-tagged YM, suggesting a role for YM phase separation in promoting gene transcription.
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PMC2614415
Our data suggested that reduced p53 activity can lead to improved clinical outcome for ovarian cancer patients undergoing chemotherapy .
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PMC11661040
P < 0.05, **P < 0.01, ***P < 0.001) Overexpression of CGREF1 facilitates cell cycle progression and enhances cellular proliferation in osteosarcoma. (
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PMC11754094
In contrast, the end resection pathway proceeds to TMEJ, SSA or HR, according to the 5′ end resection sequence and the existence of homology sequences in neighbouring DNA.
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PMC9776316
Taken together, these data suggest that the cisplatin-activated JNK-cJUN axis contributes to the upregulation of XRCC4 in the cisplatin-resistant ovarian cancer cells exposed to cisplatin.
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PMC3730428
Indeed, we found that caspase 8 and FLIP interacted in MPM cells following treatment with AT-IAP and TNFα and moreover, FLIP(L) was recovered in its p43-form indicative of its dimerization with and processing by procaspase 8 at TNFR complex IIb (Figure 3a).
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PMC6034753
Meq-Apoptin co-transfected cells apoptosis was significantly lower than Apoptin transfected cells between 60 and 92 h. And Meq-transfected cells apoptosis was significantly lower compared to Apoptin-transfected cells between 68 and 92 h, except at 74 h. Growth curves are shown as means of six independent experiments ± standard error (SE).
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PMC11026382
Color coding follows from (a), the black dashed line indicates the distance distribution of all residues in the protein.
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PMC9386809
To our surprise, increasing the temperature or the amount of catalyst lowered the yield (Table 3, entry 9).
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PMC9739791
Approximately 50% of oxaliplatin was released, thus showing the possibility of photorelease of oxaliplatin from prodrug 30 under near-infrared irradiation.
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PMC11742431
Structural stability of KVN and K14N proteins at different temperatures was analyzed by circular dichroism. (
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PMC10142392
In addition to several experimental approaches, physicochemical models have been used to predict the charge and stability of the drug based on compatibility parameters between the polymer and the drug .
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PMC11679892
Our study supports these literature findings and shows that P. sidoides may be an effective herbal agent, especially in increasing oxidative stress.
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PMC8481254
Scale bar: 500 µm.
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PMC9429973
Secondary outcomes included mortality, length of stay, all-cause 30-day non-elective readmission rate, and total cost of hospitalization.
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PMC5941560
Although the number of publications using Jurkat dropped off over the following decade, it is still widely used in biomedical research (Fig. 1).
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PMC11092382
Although the pharmacological effect of sophocarpine was described in this review, current preclinical works have focused mainly on verifying the therapeutic effect of sophocarpine on various disease models or cell lines.
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PMC11519567
Scale bars, 5 μm.
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PMC9429973
Aims: The phase 2 trial 2018-04 from the Intergroupe Francophone du Myelome (IFM) is evaluating an intensive strategy with Dara-KRD induction and consolidation plus double transplant in HR TE NDMM (NCT03606577).
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PMC9275501
Liposomes have the characteristics of nanoscale, biofilm-like structure, good biocompatibility, and relatively stable.
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PMC10900886
Gating strategy to determine EV-D68 VP1 cells.
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PMC11394730
Curcumin regulates cytokines, different kinase proteins, growth factors, and their receptors, all of which are involved in the growth and advancement of the cell cycle .
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PMC11402217
High DKK1 expression levels in bone malignancies like multiple myeloma and metastatic bone tumors can disrupt bone formation and encourage resorption, leading to bone degradation.
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PMC9596868
Data represents mean ± SD of three or more independent for PA-1, A2780 and OVCAR3 and two independent experiments for OSE cells, respectively. (
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PMC11708541
An innovative selective CDK8 inhibitor against colon cancer discovered was reported in vivo.
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PMC11478724
After overnight incubation under proper cell growth conditions, 20 µl of PMX (IC50 dose) was added to each well.
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