Datasets:
OTAR3088
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BioData-CellLine_annotated

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PMC9587298
A gradient elution program was applied at a flow rate of 0.45 mL min − 1, as follows: 1 % B kept from 0 to 3 min; 1–31 % B from 3 to 30 min; 31–100 % B from 30 to 32 min, and 100–1 % B from 32 to 36 min, keeping 1 % B from 36 to 40 min for column re-equilibration.
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PMC9479186
In mammals, Complex I is composed of 45 subunits and must be properly assembled to form a functionally mature complex (23, 24).
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PMC5363531
SRC phosphorylation was partially restored in the rD condition.
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PMC11389534
Poly‐UFMylated ASC1 promotes the assembly of p300, SRC1, as well as itself at the promoters of ERα target genes, thereby influencing tumour formation.
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PMC11283030
Migration and invasion assays were performed using transwell chambers (Corning Costar, USA).
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PMC10728200
Significance denoted by: ns not significant, *P < 0.05, **P < 0.01, and ***P < 0.001.
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PMC5963610
Data are represented as mean±SD (n=6).
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PMC11774747
Similarly, Landmeier et al. observed that CD19-CAR-VST did not expand after stimulation with a CD19+ cell line (95).
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PMC5810978
However, this positive result was inconsistent.
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PMC11745823
The luciferase assay demonstrated that the upregulation of HIF‐1α resulted in enhanced activity of the wild‐type (WT) RIT1 promoter, as evidenced by increased luciferase activity.
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PMC11087301
Concurrent angiogenesis as well as CD31 and VEGF expression were promoted due to P2 × 7R amplification, as well .
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PMC10976516
Well-tolerated treatment, with only mild toxicity, with the potential to achieve clinical responses in patients with advanced tumors.
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PMC11750161
The PCR products were ligated into the pGEMT-Easy vector and the sequence of each mutant was confirmed by DNA sequencing.
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PMC11741906
Additionally, wide profiling studies have provided a broader view of miRNA dysregulation in cisplatin resistance by using microarray platforms miRNAs and chips LNA technology.
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PMC11473750
The p-values were calculated using two-sided log-rank tests between each RNF121 (lw, hi) expression group after subdividing cohorts by MYCN amplification status.
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PMC11792090
Genomic DNA was extracted from both unmodified and modified CAR-T cells, followed by PCR amplification targeting specific sites using the primers listed in Supplementary Table S1 .
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PMC11507371
ROS are naturally generated as by-products of numerous cellular mechanisms, including mitochondrial respiration, and regulate cellular redox balance .
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PMC11748618
Fig. 6Spearman correlation of imputed CHD1L genetic variant weights against HIV set-point viral load in 3,886 individuals of African ancestry as part of the International Collaboration of Genomics for HIV.
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PMC10831439
Second, both untransduced and CD19-CAR-iNKT cells maintained or even improved their ability to decrease alloreactive T-cell activation and proliferation in the presence of nivolumab (figure 5C).
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PMC9966931
The effect of spore germination inhibition exhibited by the hybrid molecules was assessed by means of a previously reported slide assay with some modifications.
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PMC10495912
Additionally, CAT enzyme activity was determined based on absorption changes of purpald-formaldehyde complex at 560 nm, as explained in kit brochure purchased from Kiazist Company, Iran (Cat no: KCAT96).
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PMC9429973
Results: The cohort included 77 newly diagnosed DLBCL patients treated with R-CHOP.
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PMC9509578
Yang et al. demonstrated the application of silver nitrate nanoparticles (AgNPs) to target angiogenesis by downregulating VEGF and GLUT1 gene expression and inhibiting HIF-1α signaling in MCF-7 cells .
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PMC11763111
Gene Set Enrichment Analysis (GSEA) was carried out using the software GSEA_4.3.3 provided (Broad Institute), utilizing gene sets from The Broad Institute Molecular Signature Database, including:GSE26928_NAIVE_VS_CENT_MEMORY_CD4_TCELL_UPGSE9650_NAIVE_VS_MEMORY_CD8_TCELL_DNKEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTIONGOBP_T_CELL_CYTOKINE_PRODUCTIONGOBP_CANONICAL_NF_KAPPAB_SIGNAL_TRANSDUCTION GSE26928_NAIVE_VS_CENT_MEMORY_CD4_TCELL_UP GSE9650_NAIVE_VS_MEMORY_CD8_TCELL_DN KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION GOBP_T_CELL_CYTOKINE_PRODUCTION GOBP_CANONICAL_NF_KAPPAB_SIGNAL_TRANSDUCTION CAR-T/PCDH-T cells were co-cultured with CCRF-CEM cells in a 1:1 ratio.
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PMC8913139
More importantly, miR-448 mimic-mediated inhibition of cell proliferation was impaired by upregulation of ROCK1 (Figure 5(b)).
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PMC8427838
Immunofluorescence staining of kidney tissues from wild type mice (TMIGD1 + / +) and TMIGD1 KO mice (TMIGD1−/−) revealed that, while moesin is largely localized to the apical membranes of renal epithelial cells in the TMIGD1 + / + mouse, this apical localization and organization was decreased in TMIGD1−/− mice (Fig. 3B).
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PMC10788478
A total of 309 DEGs were identified in HCC15 cells, and the 10 most significant DEGs (the genes ranked by p‐values) were RPL36A‐HNRNPH2, ANKRD20A1, UHMK1, CKAP4, ELL2, CPEB3, ZNF213, SMIM13, DDAH1, and SUZ12 (Table S6).
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PMC11468365
These features enable effective training of machine learning models on molecular data and summarized in Table 2.
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PMC11724582
The results revealed that the expression level of YAP/TAZ in EGFR wild-type A549 cells was lower than that in EGFR T790M mutant H1975 cells and that CAF intervention reduced the expression of YAP/TAZ in H1975 cells in the presence or absence of almonertinib.
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PMC11634027
Mitotic clones of ds also did not have evident effects on Dachs levels or localization (Fig. 5B).
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PMC11441402
This method assumes that dead cells are removed from the environment after cell fixation, and therefore SRB is only binding to protein of live cells.
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PMC10976516
According to their findings, systemic infection with combined CIK-KGHV500 considerably slowed the growth of KRas mutated lung cancer xenografts when compared with mice given KGHV500 therapy alone.
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PMC11225860
Aurkin A treatment showed 83.8% normalploid and 16.2% polyploid cells respectively.
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PMC11695623
Correlation analysis of glycolysis-related gene sets with DCUN1D5 expression in the GEPIA2 database. (
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PMC11705630
The results were represented as mean ± SD.
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PMC11411131
In this study, we first selected TrxR1 cDNA as a basic sensor construct to monitor MeHg cytotoxicity.
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PMC11509309
To explore the potential of marine organism chemodiversity, we studied organic extracts (Table S1) of 141 tropical invertebrates from French Polynesia and Wallis and Futuna , 25 macroalgae from French Polynesia , and 3 cyclolipopeptides known as alterins produced by Pseudoalteromonas strains isolated in Brittany .
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PMC9429973
Infectious endocarditis (2 pts), meningitis (2 pts), colitis (9 pts), colon gangrene complicated by peritonitis (1 patient) were less common.
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PMC8806312
Therefore, the exploration of new immune factors may offer novel molecular targets in this tumor therapy method.
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PMC5034105
Non-attached virus was removed by washing the cells twice in phosphate-buffered saline (Gibco, Thermo Fisher Scientific, Waltham, MA, USA).
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PMC11190062
We found that four TLR genes correlated significantly with chromosomal abnormalities, of which TLR2 correlated with t(14:20) and t(14:16), TLR1 correlated with t(12:14), and TLR8 and TLR10 both correlated with t(4:14) ( Figure 1B ).
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PMC9429973
Image: Summary/Conclusion: AdvSM patients treated with avapritinib experienced significantly longer DOT and greater reduction in serum tryptase levels compared to patients treated with BAT.
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PMC11588008
Cell dosing: After 24 h of cell treatment, different groups of dosing treatments were performed, with three parallel wells set in each group, divided into five different treatment groups.
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PMC11218145
Data are expressed as mean ± standard error and the statistical significance (p<0.05) of the comparisons between controls and treatments is indicated by the asterisk (*) Effects of TB on ERK1/2 and p38 phosphorylation and BAX.
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PMC8097906
Cells were 48 h adapted in assay medium, 48 h pre-treated with different concentrations of plant extract (VSM and LW) and plant-derived compounds (Geni, Seco, Mata, Daid and Jaspl.),
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PMC10713411
Receiver operating characteristic (ROC) curve analysis was then utilized based on the survivalROC R-package to estimate the risk signature’s predictive accuracy on patients’ prognosis.
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PMC11742864
Approximately 45–69% of patients with lung cancer treated with chemotherapy or other treatments are malnourished, resulting in a poor response to therapies.
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PMC11787381
Bambuterol was solved in culture medium and preincubated for 1 h before Aβ application.
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PMC11345828
H NMR (400 MHz, CDCl3) δ 7.73 (d, J = 8.6 Hz, 1H), 7.40–7.29 (m, 2H), 7.10 (d, J = 2.3 Hz, 0.66H), 7.06 (d, J = 2.3 Hz, 0.34H), 6.88–6.83 (m, 1H), 6.63 (s, 1.3H), 6.61 (s, 0.7H), 4.47–4.18 (m, 2H), 4.06–3.95 (m, 7H), 3.91 (s, 0.7H), 3.90 (s, 0.3H), 3.87 (s, 2H), 3.86 (s, 1H), 3.58 (d, J = 12.2 Hz, 0.3H),3.53 (d, J = 12.2 Hz, 0.7H), 3.45–3.30 (m, 2H), 2.32 (s, 6H), 2.28 (s, 3H), 2.22–2.15 (m, 2H), 2.10 (s, 1H), 2.08 (s, 2H), 1.30 (d, J = 6.5 Hz, 2H), 1.22 (d, J = 6.6 Hz, 1H), mixture of rotamers.
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PMC6102174
Most of the new lignans displayed anti-HBV property, especially (−)-dihydrodehydrodiconiferyl alcohol (158) showed moderate activity inhibiting both HBsAg and HBeAg secretions with IC50 values of 0.06 (SI = 8.8) and 0.53 (SI = 1.1) mM, respectively.
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PMC11665584
NETosis occurrence is low in both healthy wounds and DFUs that eventually heal by the recruitment and activation of FOXM1 neutrophils while nonhealing DFUs have low expression of FOXM1.
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PMC5308810
When used in combination with other cytotoxic agents including doxorubicin and cisplatin, it displays synergistic cytotoxicity and the inhibition of cell invasion, migration, and colony formation in OVC.
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PMC10047551
For neither the HCC827 cell clones nor a group of 13 additional NSCLC cell lines did we identify a significant correlation between the DNA methylation of these CpG sites and mRNA expression (Figure S2D–F).
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PMC11532793
This article further develops edgeR's divided-count approach for differential transcript expression (DTE) analysis of RNA-seq data to produce a faster and more accurate pipeline.
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PMC9429973
We hadn’t observed paraprotein secretion in group of pts with c-MYC/BCL2 HGBL DH or HGBL TH that could highlight pathogenic differences between c-MYC/BCL2 HCBL DH and HGBL TH from c-MYC/BCL6 HGBL DH and HGBL NOS.
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PMC11787651
A and B, volcano plots illustrating differentially expressed histone PTM marks for entinostat–control samples observed using the 10-min and 55-min methods.
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PMC9031474
Drimane sesquiterpenoids are characterized by a trans-decalin core structure and common methyl groups at the C4 and C10 positions .
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PMC9429973
The primary endpoint is investigator-assessed PFS.
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PMC11252553
treated with cysteine (100 µg.
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PMC11635087
Additionally, fluorescence intensity (F) and quantum yield of photosystem II (φII) images for the whole field of view were acquired.
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PMC11530949
This figure illustrates the synthesis of silver-doped copper oxide nanoparticles (Ag-doped CuO NPs) using *Ephedra intermedia* leaf extract, which acts as a reducing and stabilizing agent.
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PMC11748618
To identify combinations of likely causal variants, we applied the Bayesian Imputation Based Association Mapping (BIMBAM) Bayesian framework to the functional variants and calculated the Bayes Factors (BF) for multi-SNP models to be driving the association.
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PMC5811757
Plates were placed on a mechanical plate shaker for 10 min prior to measuring the absorbance of each well at a wavelength of 490 nm using a spectrophotometer (PG Instrument T80, PG Instrument, England).
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PMC5034105
This was performed as we previously described with modifications.
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PMC9429973
Prognostic factors were evaluated as a secondary objective.
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PMC9429973
In cases of PR after 6 cycles or progression at any treatment stage or relapse (a total 14 patients) we performed the second tumor biopsy.
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PMC9368503
The mechanistic basis for this heterogeneity is currently unknown and there are no predictive biomarkers available for stratification in order to rationally target the right drugs to the appropriate patient population.
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PMC11721587
CK1δ was purchased from NEB (#P6030).
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PMC5535901
The following day, cells were treated with I3C (10, 25, 50 µM) or DIM (5, 10, 25 µM) for 48 h (within the 48 h time frame, cells were replenished with fresh media and I3C/DIM after the first 24 h).
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PMC8409415
However, several limitations should be noted.
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PMC11609529
The YM fusion protein is absent in normal cells and arises exclusively in cancer cells due to an intrachromosomal inversion that generates the chimeric YM gene.
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PMC9424261
We then further explored how HERPUD1 affects GSH content.
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PMC10926885
Using the R package ‘pROC’ (v1.17.0.1), ROC curves of NDE1 in various malignancies may be produced to evaluate the diagnostic usefulness of NDE1 in pan‐cancer.
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PMC11666785
B Alongside localization precision plot is also displayed.
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PMC9429973
Results: 43 patients with tMZL (21 males, median age 66 years (range 40-86), 74% advanced stage) were identified.
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PMC9429973
Results: Of 19 pts who completed the core period, 17 entered the LTE (mitapivat 100 mg BID, n=16; 50 mg BID, n=1).
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PMC11782508
The purified azurin fraction (Lane 4) revealed a protein band with a corresponding molecular weight of approximately 14 kDa (Fig. 4b).
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PMC9621239
Hence, further animal experiments based on the tail vein injection of a vector expressing HBx-T81P/T101P/L123S are required to directly verify the effect of HBx-T81P/T101P/L123S on inducing hepatocarcinogenesis, which could contribute to the construction of an HBV-related orthotopic liver cancer mouse model free of chemical and physical inducements.
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PMC11740508
At these doses, the M231 xenografts showed no effects of Deci treatment (Fig. 5A green versus black lines) and Deci did not add benefit to Tala treatment (red versus blue lines).
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PMC9429973
At a 56.2-mo median follow-up, median times to very good partial response or better (≥VGPR) and complete response or better (≥CR) were shorter with D-Rd vs Rd in the overall study population and in the subgroups of patients with and without renal impairment (Table).
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PMC9065483
This correlated with a shift from IFN-1 type toward IFN-2 type virus-induced gene expression profiles in a variety of cell types.
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PMC2944824
This is because stress at each organelle induces apoptosis through distinct mechanisms.
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PMC10999934
In the present study, the initial analysis of GSE158937, a single-cell RNA sequencing dataset of high-grade serous ovarian cancer, revealed that nearly all epithelial cells were cancerous Interestingly, the results of the “Scissor” algorithm showed that most cells associated with chemoresistance were epithelial cells.
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PMC11781181
Owning to the usefulness of human leukocyte antigen (HLA) screening before administering specific drugs, the incidence of SJS/TEN has significantly decreased in recent years.
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PMC11634027
If Lft, Dachs, and Sple have differential binding regions, this might be revealed by smaller deletions.
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PMC11650848
Whole blood DNA was available from 23 participants at this timepoint and was extracted and assayed using both the rs365052 SNP and CpG pyroassays.
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PMC9784246
All data have been reported as the mean ± SE of triplicate results .
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PMC11391695
A Image of nude mice inoculated with nc/PEI/NPs@M and pcDNA/PEI/NPs@M treated HCC cells on left and right sides of armpit for 21 days, respectively; B images of subcutaneous tumors in nude mice after surgical dissection; C tumor growth volume and weight measurements of the tumors in nude mice; D 21-day growth curve of tumor in nude mice was drawn; E the expressions of Ki67, PCNA, Bcl-2, MMP2 (biomarkers of tumor proliferation, apoptosis and metastasis) and ACYP2 in subcutaneous tumors were detected by H&E and IHC staining.
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PMC4839679
Error bars represent s.e.m. (
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PMC2118063
First, we transfected primary CD19 tonsillar B cells with a construct expressing an enhanced GFP (EGFP)–tagged WT mouse IRF8.
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PMC9412887
The smaller the cell–nanoparticle contact points, the more easily nanomedicines internalize into cancer cells.
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PMC9261184
Each area was surveyed around five times over the voyage.
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PMC11026382
Next we examined the structural pattern of biochemical epistasis at the residue level across DHFR.
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PMC9429973
While limited AM levels can be overcome by repetitive dosing, AM internalization potentially also contributes to faster off-switch dynamics.
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PMC11739670
Equilibrium dissociation constants (KD) of (A) TCR:pMHCI binding measured for a number of thymically selected TCRs against peptides presented by HLA‐A1 (blue), HLA‐A3 (red), HLA‐A2 (black) and HLA‐A24 (purple) (single measurements of different pHLA's) compared with (B) pMHCI:CD8αβ binding measured for the same alleles (four experimental repeats for each allele).
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PMC9429973
H. J. Lee, M. H. Chang, S. V. Anh, D. W. Kim, Y. E. Lee Internal Medicine, Dongguk University Ilsan Hospital; Internal Medicine, National Health Insurance Service Ilsan Hospital, Goyang-si; Health Convergence, Ewha Womans University, Seoul; Information and Statistics, Gyeongsang National University, Jinjoo, South Korea Background: Diffuse large B cell lymphoma (DLBCL) is the most common type of B cell lymphoma.
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PMC10656496
Overall, osteosarcoma cell lines typically demonstrated a trend toward copy number gains.
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PMC10073922
Quantitative real-time PCR was performed using specific primers (Table 1), SYBR-Green master mix, and the Rotor-Gene Q (Qiagen.
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PMC11637820
The non-ionized argon feed gas exposure (120 s) did not disrupt the biofilm activity in our study.
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PMC9503541
Because metabolomics studies generate a large amount of data, multivariate data analysis must be used to derive conclusions from the results.
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