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OTAR3088
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BioData-CellLine_annotated

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PMC8041314
Amongst these, 73,575 candidates included at least one clear positive hit substructure, while 45,506 of them did not have any clear negative hit substructure.
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PMC6684588
All studies were performed in accordance with the relevant guidelines and regulations.
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PMC11469524
PI3K -> Btk’ and BL-41_network_model.html: Tab ‘9.
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PMC11802855
All primer sequences used in this study are shown in Supplementary Table 2.
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PMC11787381
Control: white.
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PMC9516447
Moreover, GRP78 knockdown has no effect on the levels of eIF4A, eIF5A and PEAK1 reported to regulate KRAS translation .
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PMC9429973
Primary endpoint was renal overall response rate (ORR) at 3 months.
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PMC10204952
However, the regulatory functions of the most upregulated gene CST2 and most downregulated gene HYOU1 are less known in breast cancer.
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PMC11782508
Our study confirms a significant increase in total cell apoptosis of MCF7 cells treated with azurin compared to the control.
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PMC11345828
F. Comparison of relative tumor volumes for each dosing cohort.
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PMC11723947
The RNA libraries were prepared from purified RNA (RNeasy Micro Kit, Qiagen) using the SMART-Seq® v4 PLUS kit (Takara Bio) and the SMARTer RNA Unique Dual Index kits (for naive CD4 T cells and Tconv isolated from transplanted mice), or using the TruSeq® Stranded Total RNA Library Prep Gold (Illumina) and IDT for Illumina TruSeq UD Indexes (for Treg) or using the Illumina Stranded mRNA Prep Ligation Kit and Illumina RNA UD Indexes (for memory T cells).
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PMC10812665
Whether this is due to an altered level of one of the other AA is at the moment speculative (flux data would be required).
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PMC10812665
For the metabolomics analysis, four treated samples per time point were used; the untreated control values are based on six samples.
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PMC11674834
A previous study reported that CHO cells transfected with NAT1*14B cells had higher covalent DNA adducts following treatment with 4-aminobiphenyl .
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PMC11470381
Prolonged incubation of cells in the nucleofection solution causes a drastic reduction in cell viability.
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PMC9429973
RVd= 34 mos.,
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PMC11092382
The antitumor effect of sophocarpine on prostate cancer was explored.
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PMC11095939
As such, about 70% of control cells and over 90% of Mecp2 KD cells reentered the cell cycle at 6 hr post-SR, indicating that Mecp2 KD accelerated quiescence exit in 3T3 cells.
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PMC6222726
B. fagaroides var.
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PMC8875242
All other reagents were of analytical grade.
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PMC7723249
Data show the relative variation of viral RNA in comparison to control (mock).
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PMC3019555
The polysome profile of HIF-1α was also altered by MTDs in MDA-MB-231 breast cancer cells and PC3 prostate cancer cells (unpublished data), suggesting that the drug-induced inhibition of HIF-1α translation is not cell type dependent.
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PMC11680982
To assess the subtypes of HR/HER2-0 and HR/HER2-low breast cancer, 50 genes across diverse breast cancer cell lines were examined using PAM50 typing (GSE212143) derived from transcriptome data in the GEO database.
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PMC10291556
The NMR was subsequently set up to measure one 128-scan experiment after another for 4 h, at which point the sample was removed, stored, and scanned again after 24 and 48 h. Three reduction studies were undertaken using complex 4 (7.0 mg) together with ascorbic acid (2.5 mg, 3 equiv), complex 4 (6.1 mg) together with glutathione (GSH) (7.0 mg, 5 equiv), and complex 4 (15.4 mg) together with ascorbic acid (17.5 mg, 10 equiv).
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PMC8557138
A heterogeneous mixture of isolated cells is proportionately mixed with desired biomaterials to produce bioink.
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PMC11023271
We hypothesize that the release of LPA during wounding or other pathological condition results in reduction of RIPK4 in keratinocytes, contributing to keratinocyte proliferation.
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PMC4816271
T-cells expressing the hinge variant showed little detectable proliferation, which is consistent with the reduced ability of this receptor to mediate IL-2 release.
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PMC9429973
Aims: Description of presenting features and outcomes of MM patients ≤45 years.
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PMC6643347
The extracts were filtered, dried over anhydrous sodium sulfate, and evaporated in a nitrogen current.
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PMC3681794
HIF-1 function is important for resistance to multiple cytotoxic agents including etoposide, doxorubicin and cisplatin.
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PMC11787651
A 25% solution of propionic anhydride in acetonitrile (ACN) was added to each sample at a 1:2 ratio.
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PMC11552389
Notably, we found that the time point at 24 hours post-injury exhibited the most significant cell migration in A375 and A875 cell lines, emphasizing the observable changes at this crucial time point (Figure 2E and F).
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PMC10565698
Furthermore, in the cell invasion assay, the invasive ability of cells was reduced after circUSP10 knockdown (Fig. 2N and O).
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PMC9429973
Data were analyzed using SPSS.
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PMC3675084
In paclitaxel-resistant OVCAR-3-TR and SKOV-3-TR cells, the endogenous expression of BubR1 became undetectable (Figure 5A, B).
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PMC11451940
Anal.
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PMC9429973
However, differences in OS probability were not statistically significant for ptn attaining deeper responses (p<0.5 for MR3, p<0.076 for MR4, p<0.141 for MR4.5, and p<0.084 for MR5).
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PMC11082662
Western blotting showing the protein level of SMPDL3B after ACER2 knockdown; n=3. (
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PMC11528603
Hence, this finding suggested the involvement of apoptotic intrinsic cascade of SA-EA treated HL60 cells.
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PMC9429973
However, its comparative efficacy with other treatments is not known.
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PMC11637284
To ensure that mini p166-HA was imported into mitochondria it was N-terminally fused to the mitochondrial targeting sequence of trypanosomal mtHsp60 (Fig 4A) .
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PMC11656657
The ERMS cell lines SMS-CTR and JR1 cell lines, the ARMS RH4, SCMC and RH30 were kindly provided by Dr R. Rota (Bambino Gesù Children’s Hospital, Rome, Italy).
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PMC10999934
And we believed that our results confirmed that the unique algorithm is reliable and effective again.
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PMC11188874
H, Effect of HDAC6 inhibitors on proteasome ChT-like activity in MMCLs.
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PMC11629143
ChIP‐qPCR using anti‐TBP or anti‐Pol II antibodies was carried out with primers against the CMV promoter region around the transcription start site.
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PMC10135767
Kindlin family members are FERM domain-containing proteins that interact with the integrin β tails.
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PMC4816271
Since retroviral expression results in a normal distribution of expression intensity, one consideration is escape of low level iCasp9 expressing CAR T-cells.
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PMC11306331
Nevertheless, we anticipate that OptoMBP and related approaches will be useful to better understand the role of transcription factor condensates in gene expression contexts where condensation may be as likely to interfere with gene expression as it is to promote it.
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PMC9429973
In one case treatment discontinuation was due to consent withdrawal and one patient was lost to follow-up.
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PMC11704834
Molecular characterization of the transcriptional and epigenetic machineries regulated by EGFR-TKIs will yield novel targets to potentiate the antitumor effect of EGFR inhibition therapy.
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PMC10976516
Due to the high EGFR expression in A549 lung tumor cells, ICOVIR15-cBiTE induced a much higher tumor clearance than the unarmed ICOVIR15.
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PMC11705067
The combination of targeting FDX1 and DLAT may be a novel insight into the induction of cuproptosis in ccRCC.
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PMC11640115
Notably, the imGPS can be calculated using daily peripheral blood data without high-cost tests such as TMB, which require next-generation sequencing.
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PMC11681005
The HES4, GPX4 and YWHAZ genes are in the 7th cluster (hypoC7), which is a set of enhancers that are lost in basal cells. (
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PMC11335267
Fitted apparent diffusion coefficient (ADC) values obtained from the arcuate nucleus (ARC), the ventromedial hypothalamus (VMH) or the dorsomedial nucleus (DMN) using fDWI in fed or fasted mice (blue dots, wild type; red dots, Alx3-ko).
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PMC11024707
Mi-RNA-146a was shown to be expressed in regions, that are important for cognitive and social functions, such as the frontal cortex, amygdala, and hippocampus .
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PMC9429973
Results: We identified 4,789 patients with pITP, 654 patients with sITP, and 217,370 comparators.
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PMC11395280
All the mouse manipulations were carried out under the approval of the Institutional Animal Care and Use Committee (IACUC Protocol #A201310 approved 2/2022).
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PMC2196094
Genomic DNA was prepared from Sprague Dawley rat liver as previously described (56).
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PMC10728535
This necessitates understanding the molecular mechanisms of platinum resistance.
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PMC6461034
This group of kinases is important in sustaining and initiating cellular proliferation through activation of the MAPK and PI3K/AKT pathways (van der Veeken et al, 2009; Yamaguchi et al, 2014; Fig 7B).
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PMC6222726
Lignans 26–28 showed moderate activity against KB and HF-6 cell lines when compared to 19.
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PMC11633763
Although recent advances in adjuvant and neoadjuvant chemotherapy have improved the quality of life and survival rate of patients with osteosarcoma.
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PMC11697189
In the high-risk group, the infiltration levels of plasma cells, macrophage M0, T cell CD8, T cell regulatory factors (Tregs), T cell CD4 memory activation, and T cell follicular helper were higher.
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PMC9429973
Testicular relapses usually occur late (> 6 months after completion of frontline treatment), and boys with a ETV6::RUNX1 fusion gene positive ALL have a significantly higher risk of a testicular relapse.
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PMC10938336
In network pharmacology, synergy is explored through the intricate mapping of drug–target interactions within biological networks.
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PMC11476106
In other cancers, such as lung adenocarcinoma or ovarian carcinoma, VN has been shown to become a potent pro-migratory factor in plasma and other fluids, which, when released from its inhibitory complex with fibrinogen, facilitates cancer cell escape from the tumor, spread through the blood stream and lymphatic system, and subsequent metastasis to body cavities with low levels of fibrinogen .
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PMC11064533
Genes categorized as “Inorganic transport and metabolisms,” and “Coenzyme transport and metabolism,” were significantly upregulated in clumps, and similar expression pattern was observed in biofilms by E. coli K-12 and symptomatic bacteriuria E. coli.
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PMC11695623
The difference of DCUN1D5 protein expression in cancer and paracancerous tissues in UALCAN database. (
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PMC10344560
No inflow nor outflow obstruction was found, therefore he could maintain good ultrafiltration with no sign of fluid retention.
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PMC11422497
OD, Optical Density.
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PMC10604092
Subsequently, we added streptavidin–horseradish peroxidase and chemiluminescent detection reagents to the membrane.
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PMC8567602
Indeed, we observed a slightly increased portion of CBAF remaining on insoluble chromatin after nuclear extraction in the presence of the fusion (Fig. 7F), fitting the increased affinity for chromatin conferred by the fusion's SSX tail (38).
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PMC9429973
Pts who are refractory to an anti-CD38 monoclonal antibody or had prior BCMA-directed tx are excluded.
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PMC11244823
The structure of the motif encompassing Asp43 to Asn63 had no effect on gD1_83 but forced a different structure on gD1_160 (magnified in E) as compared to the structures predicted for gD1_402 (magnified in G) and gD1_180 (F).
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PMC8041314
Only the IC50 value of compound 26 determined in the daunorubicin assay (ABCC1) fell out of the correlation, which was with 0.764 μM over 12 times lower than could have been expected from the calcein AM data.
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PMC11489175
In this context, a key observation is that USP1 regulates EMT by deubiquitinating Snail, thereby preventing its degradation.
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PMC9777812
Studies reported that knockdown of CDKN1A increased cell proliferation through activating the PI3K/AKT pathway and miR-93 promoted cell proliferation, migration, and invasion by activating the PI3K/AKT pathway via inhibition of CDKN1A in human and mouse .
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PMC8973085
Molecular docking has become a widespread tool for drug discovery.
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PMC11519583
Ror2 mice were generated as described previously .
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PMC11770130
In the CNS, treatment of ceramide synthesis inhibitor myriocin or depletion of CerS6 suppressed the ER stress in the hypothalamus.
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PMC10507284
A prognostic nomogram consists of age, metastasis status, and TROAP‐derived risk scores for predicting the 1‐, 2‐, and 3‐year survival rates of STS patients (n = 263).
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PMC11786600
The specific parameters were as follows: 2 mL of spinning solution; 21 G needle; DC voltage: 15 kV; spinning distance: 10–15 cm; propulsion speed: 10 mL h. The abbreviations for PED are demonstrated in Table 1.Table 1Abbreviation for PED with Different Contents of PF-127Portable Electrospinning Dressing (PED)AbbreviationsPVBKaempferolPF-1275%0%0%PED05%0%10%PED15%0%15%PED25%0%20%PED35%1%15%PED4 Abbreviation for PED with Different Contents of PF-127 The surface characteristics of the PED dressings were examined using scanning electron microscopy (SEM; Phenom Pro, Thermo Fisher Scientific, USA).
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PMC10988555
Nonetheless, when the NN ligand changes from the bipy-based (1–2) to phen-based (3–4), a slight contraction of the Co–P bond is observed (from 2.30 to 2.28 Å) with a concomitant slight elongation of the Co–N bonds (1.93–1.94 Å).
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PMC8873393
We noticed that there was a tendency for genes with transcription recovery in their coding regions to be short (Fig. 4A–C), with mean length of CDS being 1287 nt for “recovered genes”, compared to 1549 nt for “not recovered genes” (median length was 837 bp, compared to 1026 bp respectively).
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PMC11621565
The spikes after 72 h represent the pause of readings while changing the medium.
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PMC10772747
Apoptosis Induction and Cell Cycle Arrest As further evidence of the pharmacological network analysis results indicating the involvement of EBE compounds in apoptosis and cell cycle regulation in breast cancer cells, we conducted apoptosis and cell cycle assays in our study.
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PMC11794847
All statistical analyses were performed using the SPSS software (version 24.0, IBM Corp., Armonk, NY, USA), and GraphPad Prism (version 8.0, GraphPad Software, San Diego, CA, USA).
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PMC11564405
The analysis results of TCGA-LUAD and TCGA-LUSC cohorts revealed that the total anticancer immunity score, cancer antigen presentation score, priming and activation score, T cell (CD4 + and CD8 + T cell) recruiting score, and immune cell infiltration score were significantly higher in high RILPL2 expression groups, which suggested the NSCLC patients expressing high levels of RILPL2 might experience an improved anticancer immune response.
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PMC11705862
Fiji program was used for the quantifications, where a manual threshold was adjusted for each case, and region of interest (ROI) (drawn around single neurons) was selected.
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PMC11721587
The cells were collected 48 hours after the transfection.
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PMC11705630
The function of GLDC in the tumorigenesis of hepatocellular carcinoma (HCC) is conflicting.
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PMC11617590
SFN was purchased from Penielbio (Daegu, Korea).
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PMC11509224
It was the first instance of a 3,4-seco-3,19-dinorspongian diterpene bearing a rare pyridyl D-ring system.
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PMC9429973
Compared to AML, Acute lymphoblastic leukemia (ALL) in 80% cases occurs in children.
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PMC11488203
The biogenesis of miRs includes a predominant canonical and further alternative pathways.
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PMC11723210
In Figure 5(f1–f6), phase values are extracted along the white lines shown in the corresponding cell images and plotted as quantitative curves.
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PMC11055323
SS, SS18-SSX1 Onco-condensate remodels H3K27ac.
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PMC11095939
E–H) Either Nr1h3 or Rara KD further enhances quiescence exit in Mecp2 cKO livers. (
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PMC11525028
Dual-luciferase reporter assays of ASNS promoter activity in ATF4-KD 143B (left) and HOS (right) cells (n = 3). (
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