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OTAR3088
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BioData-CellLine_annotated

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PMC11754436
Quantitative analysis of apoptosis rate of 143B cells in different groups, *Represent comparison with the NC group. (
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PMC9429973
Hits that increased tumor-cell killing when combined with LCMV-primed splenic T cells were further validated ex vivo.
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PMC10523483
In general, our findings demonstrated a previously unknown role of linker histone H1.2 in NSCLC and brought a diffferent angle into the molecular crosstalk between the linker histones, antioxidant defense system, and poor response to chemotherapy in NSCLC.Nonsmall cell lung cancer (NSCLC) accounts for ~85% of all lung cancer cases, which is a highly common and malignant disease with limited treatment options (1).
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PMC11794588
Fig. 7(a) HPLC chromatogram of fraction 34 (Cestrum aurantiacum); fractions were collected per minute. (
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PMC11025866
An increase in BZLF1 and BRLF1 mRNA was observed between 6 h and 8 h ; ZEBRA protein was expressed after 15 hours, but not at 4, 6, or 8 hours .
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PMC9219615
For this assay, HL-60 or CCRF-CEM cells were seeded in 24-well plates at a density of 100,000 cells/well in 1 mL complete culture media and were treated with the 24 h CC50 or 2xCC50 of Tpz-1 and controls (as previously described) for 5 h. Three independent measurements were analyzed per cell treatment.
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PMC7917457
In this study, we have developed a double-transgene-armed adenovirus that is expressing biologically active OX40L and CD40L with levels comparable to other transgene-armed viruses reported earlier.22, 23, 24 The oncolytic potency of VALO-D102 was shown to be identical to the parental strain Ad5/3-D24.
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PMC11483468
The telomerase-containing fraction was prepared from the cell line BEL-7404. (
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PMC9847912
In this way, the final concentration of GSK232 in the culture wells was maintained as consistently as possible throughout the duration of the assay.
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PMC11774112
The data are expressed as the means ± SD.
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PMC10092581
In this framework, some of us have recently developed and fully characterized a series of NHC‐based selenoureas and their Au(I) and Ag(I) related metal complexes (Scheme 1).
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PMC11574029
Fig. 1NOTCH3 is upregulated in BLCA and associated with poor prognosis.
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PMC6643347
Some researchers believe that those cells may provide conditions favoring the selection of resistant strains.
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PMC11285179
The transwell migration assay was performed to confirm the effect of CCL28 on the migration of pericytes by using different concentrations of human recombinant CCL28 protein (Fig. 2D, left panel).
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PMC9429973
Pts received epcoritamab (weekly, cycle [C] 1–3; every 2 wk, C4–9; every 4 wk, C≥10) and GemOx (every 2 wk, C1–4) until disease progression or unacceptable toxicity (28 d/C).
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PMC10873328
The hypoxia-induced factor HIF-2α but not HIF-1α could directly bind to the promoter region of TGFBI, and facilitate its transcription level.
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PMC11746948
Human melanoma cell lines WM1361A, SK-MEL-30, A875, WM115, and WM2664 were provided by the Cell Bank, Chinese Academy of Sciences.
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PMC6222726
Bursehernin (18) is able to inhibit the growth of Neisseria gonorrhoeae .
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PMC8913139
Then, we found that miR-448 mimics increased its expression, while miR-448 inhibitor decreased its expression in A-172MG cells (P < 0.01, Figure 1(c)).
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PMC11347429
Functional analysis using GO term enrichment for the up-regulated DEGs (higher in ICU) from the contrast of infected ICU patients versus non-ICU patients. (
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PMC11359735
Gametocyte cultures were initiated at 0.5% asexual parasitemia from low passage stock and maintained up to day 18 with daily media changes but without any addition of fresh erythrocytes.
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PMC9429973
AOTR was defined as maximal amplitude up to 20% just before the next dose of ASA.
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PMC10421378
The highest glass transition temperature (Tg) value for hydroxypropyl methylcellulose (used as a coating substance) was measured at 152.6 °C.
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PMC11774747
Long-term efficacy was associated in some trials with the potential of combining TCR and CAR stimulation to enhance the durability of CAR-T cell responses, and the importance of concomitant TCR stimulated by viral antigens.
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PMC11767725
Clinical trials have demonstrated significant reductions in inflammatory lesions and improved quality-of-life metrics in patients receiving these microbiota-targeted treatments.
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PMC8010066
Furthermore, in the co-culture in the A549 cell line, a significant relationship was observed among the viability of P. aeruginosa, the activity of pathogenic enzymes, incubation time, resistance to carbapenem, and the expression of virulence genes.
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PMC4485786
CDR3 region protein sequences of selected TRBV segments; bold amino acid codes mark homologous sequences. (
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PMC11723947
Source data are provided in the Source data file.
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PMC6133382
The cell culture supernatants were then collected after 5 days and tested for binding of gp120 to the prototypic glycan-dependent, broadly neutralizing monoclonal antibody PG9.
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PMC9844987
A-B) 1st and 2nd (A), and 3rd and 4th (B) principal components (PCs), colored according to population (YRI and LWK).
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PMC11768927
Furthermore, treatment with VSV-M51R significantly reduced levels of the immunosuppressive cytokine IL-6 within the peritoneum.
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PMC10955424
A high level of HGF was detected in the malignant ascites, despite not being one of the most significant components in the ascites fluids that induce chemoresistance.
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PMC11519583
The graphs on the right show the relative band intensity of Wnt5b and Wnt11 in anti-HA immunoprecipitates, which were normalized by the corresponding levels of Wnt5b and Wnt11 in WCL (n = 5).
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PMC10968586
In a breast cancer cell line identified by the authors only by the letters “MDA”, 200 μg/mL OLE was able to interfere with the metastatic process, causing a time-dependent increase in mRNA levels of MMP inhibitors TIMP metallopeptidase inhibitor 1 (TIMP1) and TIMP3, while TIMP4 showed no further increase after 48 h incubation.
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PMC8632470
Extraction of the stems (ASE) and leaves (ALE) was performed by employing ethanol 70% for 3 × 24 h at 26°C.
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PMC10850553
We examined the immunohistochemistry of C5AR1 in 20 IA lesions and control arterial walls (superior temporal artery) obtained from a patient population different from that recruited in the RNA-seq experiment shown in Fig. 2A.
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PMC11661024
Secondly, while informative, the in vitro nature of our experiments may not completely represent the complex in vivo environment.
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PMC10669128
In this case, the advantage is represented by the close resemblance of the model to the primary tumor sample .
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PMC11748618
The orange box represents homozygous reference at all alleles, light blue as heterozygous at all alleles, and red is homozygous alternate at all alleles.
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PMC9429973
Aims: To evaluate if personalized MRD detection by ddPCR can predict clinical relapse earlier than conventional methods.
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PMC11661040
D-E) The CCK-8 assay was employed to assess the impact of CGREF1 knockdown on cell proliferation stability. (
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PMC11634794
Nonetheless, it is evident that LAMP1 exerts an inhibitory effect on ccRCC progression, as downregulation of LAMP1 expression correlates with poorer patient prognosis.
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PMC5916734
Specific productivity as the clotting activity is shown as a broken line (right axis).
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PMC9792775
LFU combined with PTX promoted the anti-tumor immune responses (A) PD-L1 expression in A-204 and HT-1080 cells treated with LFU, PTX, and LFU + PTX for 48 h by using qPCR. (
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PMC11612315
GLP-1-derived peptides (liraglutide, exendin-4, and exendin 9–39) effectively inhibited capsaicin (CAP)-induced currents and calcium responses in cultured sensory neurons and TRPV1-expressing cell lines.
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PMC11413393
The supernatant was collected, beads were rinsed with 50 mM NH4HCO3 eluates were pooled prior to the peptides being lyophilized in a vacuum centrifuge.
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PMC11499955
Short PEG spacers were introduced into the sydnonimine core leading to compound 3 whose alcohol was then tosylated to allow reaction with trimethoxybenzene phosphine and three of its deuterated analogues to obtain four phosphoniums 5 bearing TMPP isotopologues, TMPP-H33, H24, H15 and H6 (Scheme 1).
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PMC11591030
The cell viability was calculated using the following formula: Cell Viability (%) = (OD value of the treatment group − OD value of the blank group)/(OD value of the control group − OD value of the blank group) × 100.
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PMC9429973
2019;31(5):386-393).
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PMC9429973
By recreating a 3D microenvironment, the model may help to clarify the mechanisms behind drug resistance in r/r DLBCL.
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PMC11171319
Since stem cells are permissive to HCMV and the appearance of cancer stem cells (CSCs) is a main player in tumor initiation and tumor spread it’s worth questioning the genuine transformation potential of HCMV.
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PMC11291490
DuPBMCs were then treated with the collected supernatants at dilutions of 1:8 or 1:16 for a 48-hour incubation period.
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PMC11683240
This also indicates that PT is not covalently or irreversibly bound to cell surfaces.
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PMC9031474
Some sesquiterpenoids—such as artemisinin, thapsigargin, or mipsagargin (G-202)—have already entered clinical trials as novel chemotherapeutic agents, showing that this class of natural products holds great potential in anticancer therapy .
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PMC11468365
The third metric is the coefficient of determination () which measures the goodness of fit for the prediction model.
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PMC9429973
Patients who did not require change in treatment for MM were censored at the last known follow-up.
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PMC11591052
Results are presented as the means ± SEM of the three biological experiments.
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PMC10545062
The benefit of this partitioning was to minimize large fluctuations in hemodynamics in response to administered boluses while simultaneously avoiding overresuscitation.
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PMC11637276
To characterise the role of MAPK signalling in this process, we screened 4 inhibitors against p38α/β (SB202190 and SB203580), ERK1/2 (FR180204), and MEK1/2 (PD98059) on Matrigel, collagen I, and CDM uptake in MDA-MB-231 cells (S5A Fig) [46–50].
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PMC11547972
In good accordance with this, synergistic action of SFN combined with the natural compound formononetin on cervical cancer cell growth and apoptosis has recently been reported to be triggered by coupled deactivation of Akt .
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PMC10877303
As several amino acid residues involved in the non-bond interactions are located within the active site, the three top phytochemicals can be considered for potential use as a drug for antiviral therapy concerning MERS-CoV. An investigation of docked compounds from the ZINC database against the 3CL protein of MERS-CoV uncovered three hit compounds, including ZINC ID: 75121653, 41131653, and 67266079, possessing binding energies of −7.12, −7.1, and −7.08 kcal/mol, respectively .
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PMC9429973
Most CRS [95% (95% CI 88-98%)] and ICANS [75% (95% CI 63-83%)] resolved by 21 days since onset.
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PMC11612315
Baseline heat sensitivity was assessed to evaluate the systemic effects of glucose or GLP-1(7–36) administration via a hot plate apparatus (Ugo Basile, Italy).
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PMC10344560
Considering the immune dysfunction due to uremia in HD and PD patients, the study of onychomycosis in PD patients is essential because it may be one of the risk factors of fungal peritonitis.
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PMC11806613
A shift from a basal-mesenchymal to a luminal-epithelial state of breast cancer stem cells (BCSCs) as supported by the downregulation of stemness (e.g., CD44) and mesenchymal (e.g., FN1 and vimentin) markers, along with the upregulation of differentiation markers (e.g., CD24) and luminal-epithelial markers (e.g., CK19), was also observed.
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PMC11762280
F Representative images of H&E staining and TUNEL staining of skin sections from WT mice and Zbp1 mice after UVB irradiation.
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PMC11155445
Among the synthesized compounds hetero binuclear complex (78) were found more effective against CEMSS cancer cells (Fig. 21).
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PMC11301242
Sambamba was employed to remove duplicates from the alignment output.
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PMC9910796
For immunoelectron microscopy, infected or transfected cells were in situ fixed for 2 h at RT with 4% PFA or 2% PFA and 0.2% GA in 0.1 M PB.
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PMC11291697
Glycine concentration in the proband’s LCL (~1 × 10 cells) and culture supernatant was measured by using the Glycine Assay kit (MAK261; Sigma-Aldrich, St. Louis, MO, US).
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PMC9429973
R. Zinz, C. Rohde, D. Heid, M. Bruckmann, M. Bornhäuser, C. Röllig, U. Platzbecker, C. Baldus, H. Serve, F. Zhou, C. Pabst, C. Müller-Tidow, M. F. Blank Medical Department V, Hematology, Oncology and Rheumatology, Heidelberg University Hospital; University of Heidelberg Medical Faculty; Molecular Medicine Partnership Unit (MMPU), University of Heidelberg and European Molecular Biology Laboratory (EMBL); European Molecular Biology Laboratory (EMBL), Heidelberg; Medical Clinic and Policlinic I, University Hospital Carl Gustav Carus and Medical Faculty of the TU Dresden, Dresden; Department of Hematology, Cellular Therapy and Hemostaseology, Leipzig University Hospital, Leipzig; Medical Department II, Hematology/Oncology, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel; Department of Medicine II, Hematology/Oncology, University Hospital Frankfurt, Goethe-University Frankfurt, Frankfurt; Division Proteomics of Stem Cells and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany Background: Small non-coding RNAs play important roles in leukemogenesis.
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PMC9429973
In the bone marrow and spleen number of erythroid progenitors burst forming units-erythroid (BFU-E) and colony-forming unit-erythroid (CFU-E) were determined using colony asays and CD71/Ter119 profiles of erythroid cells were analyzed by flow citometry.
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PMC9429973
M. Mohty, I. Yakoub-Agha, J.-H. Dalle, M. Labopin, J. Cornillon, A. Huynh, T. Lamy, C. Soussain, K. Asubonteng, D. Gutierrez, R. Peffault de Latour Department of Clinical Hematology and Cellular Therapy, Hôpital St Antoine, Sorbonne University, INSERM UMRs 938, Paris; CHU de Lille, Université Lille, INSERM U1286, Infinite, Lille; Hôpital Robert-Debré, GHU AP-HP Nord, Université of Paris; Hôpital St Antoine, Sorbonne University, INSERM UMRs 938, Paris; Department of Clinical Hematology, CHU de St-Étienne, Saint-Étienne; Département d’Hématologie, Institut Universitaire du Cancer de Toulouse – Oncopole, Toulouse; Service d’Hématologie Clinique, CHU de Rennes, Rennes; Hématologie, Institut Curie, Saint-Cloud, France; Jazz Pharmaceuticals, Philadelphia, PA, United States of America; Jazz Pharmaceuticals, Lyon; Hôpital Saint-Louis, Paris, France Background: Hepatic VOD/SOS is a potentially fatal complication of HCT conditioning.
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PMC11587606
Primary antibodies for immunoblotting were: RHBDF1 and ZO-1 (abcam, Cambridge Science Park, UK), HA-Tag, Occludin, E-cadherin, PKCζ, p-PKCζ/λ (Thr410/403), Phospho-Tyrosine antibody, and improtin β1 (Cell Signaling Technology, CST, Boston, MA, USA), LaminB1 and GAPDH (Proteintech, Wuhan, China).
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PMC11371747
50% [H]-l-LV influx inhibitory concentrations of the LV-stereoisomers, PLX and MTX.
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PMC10222971
On the other hand, dye uptake is assessed subjectively; small amounts of dye uptake indicative of cell injury may go unnoticed .
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PMC11750712
An analogous approach for PTCL, where CAR T cells target pan-T cell antigens, could theoretically result in unacceptable profound and prolonged cellular immunosuppression.
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PMC8584319
However, the application of these agents to monotherapy is limited because of AKT activation and incomplete inhibition of 4E-BP1 function .
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PMC9429973
Best-fit models were determined through fit statistics, KM and fitted curve overlays, and clinical plausibility.
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PMC11300639
h, i 786-O cells were infected or transfected with the indicated shRNAs or plasmids for 72 h. Cells were treated with CHX, and cells were collected for western blotting analysis at different time points.
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PMC11782508
After incubation, cells were harvested by centrifugation at 4000 rpm at 4 °C, and cell fresh weight was determined.
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PMC11180402
To test whether ISO alters the methylation status of the miR-129 promoter, the methylation levels of a CpG-rich region (~ 170 bp) upstream of the miR-129 transcription initiation site were analyzed by MSP in 5637 cells treated with various doses of ISO for 24 h. As shown in Fig. 6A, ISO treatment resulted in a dose-dependent decrease in methylated DNA (M), which was accompanied by the upregulation of unmethylated DNA (U) in 5637 cells.
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PMC6461034
Kinases in bold type are intended drug targets while kinases that are off‐targets are given in plain type.
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PMC11661040
Due to the low incidence of osteosarcoma, the symptoms are not obvious, and it is not easy to be detected in the early stage, coupled with its high proliferation capacity and aggressiveness, most patients are often relatively severe when diagnosed.
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PMC11507371
A recent study further suggests Nrf2’s role in enhanced repair of double-strand breaks, which are the primary effect of radiation therapy .
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PMC11627398
Moreover, SLC31A1 gene was positively correlated with the proportions of resting NK cells and monocytes and was negatively correlated with follicular helper T cells levels; MTF1 gene was positively correlated with resting NK cells and neutrophils levels and was negatively correlated with follicular helper T cells, resting dendritic cells and resting mast cells levels; LIAS was positively correlated with naive B cells and CD8 T cells levels and was negatively correlated with resting CD4 memory T cells levels; LIPT1 was positively correlated with gamma delta T cells, resting NK cells and CD8 T cells levels and was negatively correlated with activated mast cells levels (Fig 5C). (
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PMC10890055
ATCC, the cell supplier, states 39.5 °C in their protocols, but some authors choose 37 °C for their experiments for culture differentiation .
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PMC11737091
These templates were annealed and subcloned and inserted into the sites between Age І and EcoR І to construct pLKO.1-DBF4-shRNA (named DBF4-sh1, DBF4-sh2, and DBF4-sh3).
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PMC11023271
RIPK4 mRNA was reported to decrease in levels during wounding in mouse skin .
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PMC8567602
B, WBs of glycerol gradient fractions of EXPI293T cells transfected with SS18–SSX or SS18.
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PMC11267830
c CRISPR screening data from CCLE CRISPRi revealed the dependence of T-ALL Jurkat cell survival on THOC1.
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PMC9429973
And to develop models to discriminate higher risk of organ damage and predict new-onset organ manifestation within 5 years.
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PMC11670954
Furthermore, a recent study demonstrated that the intake of BA led to a substantial up-regulation of transcripts encoding claudin-1, claudin-2, occludin, junctional adhesion molecule 3, and ZO-1 by RT-qPCR .
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PMC9429973
Image: Summary/Conclusion: Mutations in genes associated with the NFkB pathway present at baseline are predictive of response to zanubrutinib in rrMZL patients.
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PMC11422497
OD, Optical Density.
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PMC11412721
Consistent with this, a Ccr7 deficiency was shown to delay the lymphomagenesis induced by Eμ-Myc in mice (Rehm et al., 2011).
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PMC11055510
circMAN1A2 overexpression and knockdown plasmids were constructed (Fig. 2A).
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PMC11201989
Furthermore, this study may provide the foundation for understanding how PD-L1 immune therapy may affect the outcome of ciliopathy-related diseases.
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PMC9429973
Thus, the number of CFU-totals decreased from 66% recorded after 1–5.9 months of storage, to 60% after 6–10 months and to 44% of the original number when stored for more than 10 months; p=0.131.
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PMC11185260
For in vitro study, SMARCB1-deficient ATRT (BT-12 and CHLA-06) and SMARCB1-deficient rhabdomyosarcoma (A-204) were transfected with either scL-SMARCB1 or scL-vec for 24h, followed by treatment with cisplatin at various concentration. (
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