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PMC11045125
Furthermore, virally-encoded microRNAs (“BARTs”) inhibit apoptosis by reducing expression of cellular genes such as caspase 3 and the EBNA1 protein decreases p53 stability by inhibiting its interaction with USP7 .
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PMC10656496
We selected FDA-approved agents or agents with strong preliminary data for OS, clinically achievable dosages, and tolerable dosing schedules.
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PMC9429973
22/28 (79%) completed their planned quota of 4-6cycles; 6/28 (21%) did not.
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PMC11365427
We further established an OPLS-DA, a supervised multivariate statistical model, for differential metabolite screening.
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PMC9429973
Chebotkevich V.N et al., Cellular Therapy and Transplantation.
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PMC8481254
D The possible mechanism of CA to inhibit diabetes-associated liver cancer.
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PMC9429973
Analysis statistics: χ test to study associations.
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PMC10878518
Further experiments are needed to evaluate whether OBP-401-mediated GFP expression is associated with cytopathic effect in clinical tumor samples.
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PMC9429973
Importantly, bispecific antibody treatment also induced high levels of anti-CLL T cell activity in both ibrutinib responding and refractory patient samples.
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PMC7351993
For application to practical biofuel production, it is necessary to further investigate the temporal stability of lipid-rich mutants in terms of intracellular lipid concentration.
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PMC11643491
These cells were derived from the same original source and were sorted based on their phagocytic capacity.
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PMC11799620
Also, previous investigations observed this cactus property (Chen et al., 2012).
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PMC11803918
To conclude, these results revealed that hybrid exosomes retained the properties of both γδ-T exosomes and Ce6-loaded liposomes after fabrication and might be endowed with active targeting and photosensitive apoptosis functions from two components.
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PMC7519871
WDL appeared to form stronger interactions with Akt and NF-kB (Figures 4A–B and 5A–B) as compared to BA (Figures 6A–B and 7A–B).
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PMC11228511
In smooth muscle cells (SMCs), progerin increases nuclear stiffness, as judged by atomic force microscopy (21).
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PMC9622879
Moreover, at present, efficient algorithms are available in which certain MILP problems can be relaxed and solved within a reasonable amount of time when they are combined with advanced mathematical solvers (e.g., CPLEX) in commercial software.
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PMC11748335
L H3K27me3 modification near the IGF2BP1 gene in different Roadmap samples.
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PMC5311252
The entire duty cycle lasted ~1.5 s. Dynamic exclusion was used with 60 s duration.
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PMC11306331
E Schematic of approach for chemogenetic dissolution.
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PMC10196713
However, the function of Fdx1 in cancer cells and its relationship with ferroptosis remain elusive.
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PMC5810978
For all these BoNoV culture trials, the inocula were not removed after inoculation.
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PMC7305184
Our findings can hardly be compared to the results of previously reported study where a small number of generations (only 2: 1 and 2 generation) was used.
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PMC11594588
Moreover, the increased number of MCU results in oxidative stress and an increase in ROS concentration, which in a feedback loop intensifies cellular damage .
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PMC10079526
C BRCA1 knock out in RPE-1 p53 cells was validated via immunoblotting.
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PMC11547972
Synergistic, additive, or antagonistic effects between SFN and amygdalin were determined using the Bliss independence model .
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PMC11463018
H NMR (500 MHz, DMSO-d6) δ: 8.04 − 8.00 (m, 2H), 7.52 − 7.48 (m, 1H), 7.40 − 7.34 (m, 3H), 7.04 − 6.99 (m, 1H), 6.04 (s, 2H).
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PMC9429973
There was one unexpected treatment related mortality (TRM) due to massive pulmonary haemorrhage which may be related to patient’s pulmonary stent removal prior to his 6 R-CHOEP chemotherapy.
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PMC11534035
When treated with 5 μM of G36, the relative gap area at 10h was just shy of significance with a p-value of 0.0515 (10h: M=0.448±0.064 vs. control=0.657±0.050; p=0.0515), suggesting a treatment effect.
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PMC9429973
Secondary endpoints included complete response rate (CRR), duration of response (DOR), progression-free survival (PFS), overall survival (OS), and safety.
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PMC11228511
High-magnification images of the boxed regions are shown to the Right. (
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PMC10530622
The fecal microbiota transplant, which may have a great therapeutic potential, only has indication to be used for Clostridium difficile infection.
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PMC11774251
Abnormal expression of inflammatory factors and the activation of IL-17 pathways markedly influenced disease progression.
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PMC6442998
GIST882 and GIST48 cells were both sensitive to verteporfin, with a higher sensitivity for the imatinib-resistant GIST48 cells.
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PMC11474209
Bcl-2 is another protein that may have a role in MC toxicity.
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PMC11502327
Therefore, safer and more effective drug regimens are needed to improve patient outcomes.
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PMC11746948
Statistical analysis: two-way ANOVA with Tukey’s test for (b, f, k, l).
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PMC8557138
Ex vivo assays enable the spatial organization of various cell types and extracellular matrices along with spatial–temporal gradients of angiogenic factors.
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PMC11752740
CI = Combined Index Figure 6 presents the effects of pistachio hull extract, CFZ, and their combination on the expression levels of the MDR1 gene in SK-BR3 and MCF10A cell lines after 24- and 48-hours of treatment.
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PMC10669128
Another major issue is the fact that the animals are immunocompromised, hindering the immune system’s role in tumor growth, progression, metastasis, and response to therapy .
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PMC10988555
Calf Thymus DNA (CT-DNA) binding assay was performed through the UV–vis spectra from 230 to 700 nm on the spectrophotometer Evolution 300 UV–vis (Thermo Fischer Scientific, Waltham, MA, USA).
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PMC9813422
Integration of HPV DNA is commonly reported in related cancer genomes.
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PMC11422497
Establishment of xenograft tumor model in nude mice.
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PMC9479186
Besides HCC have several known risk factor such as hepatitis infections, alcohol, and diabetes mellitus.
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PMC11078693
Technical questions on executing this protocol should be directed to and will be answered by the technical contacts, Vasty Osei Amponsa (vasty.oseiamponsa@nih.gov) and Valentin Magidson (valentin.magidson@nih.gov).
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PMC11173119
We isolated peripheral blood mononuclear cells (PBMCs) in a Ficoll gradient and reprogrammed them using episomal vectors OCT4, KLF4, L-MYC, SOX2, LIN28, and Trp53 .
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PMC9429973
Iada at 90 µg/m/d is the confirmed RP2D for the combination, showing deep responses with manageable toxicity.
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PMC10761218
The increased suppression of cellular proliferation observed at higher concentrations can be attributed to the existence of phytochemicals, which possess the capability to affect the structure and functionality of cancer cells.
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PMC10329237
EMT antibodies against α-SMA, β- catenin, Vimentin, Zo-1, Snail1, Slug, and E-cadherin were purchased from Cell Signaling Technology Inc., USA.
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PMC11551844
The amount of gold (pg) internalized was calculated using the ICP-MS results and the weight of the cell pellets (after dehydration and oven drying).
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PMC10656496
Spheroid growth under nutrient deprivation. (
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PMC4112127
Consequently, tools to improve the early diagnosis of CC are urgently needed.
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PMC11283030
However, down-regulation of N-cadherin and Vimentin protein were found in ACLY silencing 786-O and A498 cells (P = 0.004, P = 0.039 for 786-O, P < 0.001, P = 0.014 for A498, respectively, Fig. 6b, c).
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PMC9429973
Futher, there were no statistically significant differences in morbidity of CMV between 5mg ATG Vs 6mg ATG and 6mg ATG Vs 16mg ATG-F(39%Vs36.1%, 36.1%Vs21.1%), but incidence rate of CMV was statistically significant difference in 5mg ATG 39% Vs 16mg ATG-F 21.1%(P=0.011).
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PMC10551595
Data were analyzed using FlowJo software version 9 (Tree Star Inc.).
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PMC11420784
n = 3 slides.
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PMC11078693
Note: In this protocol, we use phalloidin at a final concentration 100 nM by a 1:100 dilution of a 10 μM stock solution.
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PMC11732628
The total RNA was reverse transcribed into complementary DNA (cDNA) using a PrimeScript RT Master Mix (Takara Biotechnology Co., Ltd.) according to the manufacturer’s instructions.
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PMC11629461
Since activation of the single subunit NOX5 does not involve any accessory subunits of P22, P40, P47, P67, Rac1/2, , P47/P67 phosphorylation or their membrane transfer will not be indicative of NOX5 activation.
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PMC10605143
Therefore, in the next step, we aimed to study the effect of HSF1 overexpression on the MCF10A cell phenotype.
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PMC11693599
To clarify whether CD109 is localized to the exosomal fraction secreted from CSCs, extracellular vesicles were isolated from the CM by ultracentrifugation.
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PMC3888431
However, new data sets can be easily incorporated into our database to establish an up-to-date analysis platform, e.g. the protein data set published with the CHO-K1 genome is also available in the GenDBE database.
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PMC3765139
Bars represent SD.
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PMC11240448
Additionally, similarly to luminal BC, MEK and PKC can assume a secondary role as immediate oncogenic drivers in select cell lines within this group.
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PMC7154001
Following intravenous administration of TW-01003 (a piperazinedione derivative designed as an antimitotic agent), the major metabolite (TW-01003 sulfate) was detected in rat plasma.
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PMC7189327
Furthermore, they also noted that EGR1 might suppress epidermal proliferation via modulating CDC25A that is critical for cell cycle progression from G1 to S phase .
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PMC11755519
The following markers were analyzed: CD63 and CD9.
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PMC9844987
Conceptually, the frQTLs can affect decomposed promoter usage and overall promoter expression levels to different degrees, as exemplified by the promoters of genes RGS14 and GGNBP2 (Figure 5D and E).
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PMC11740207
MdPCs develop into progenitor and precursor cells: hematopoietic precursor cells (HPCs), which will give rise to blood and lymphatic cells; mesenchymal precursor cells (MsPCs), responsible for forming muscle, bone, cartilage, and adipose tissue; cardiac precursor cells, which generate various heart cells; and endothelial progenitor cells (EnthPCs), involved in blood vessel formation (Figure 1).
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PMC11694346
The H NMR spectra of the isolated reaction product BT-NH showed the disappearance of peaks corresponding to the cleaved DNBS group.
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PMC9817179
We hypothesized that the balance between interaction and fixation dynamics in a LLPS system causes the fixation artifact and tested the hypothesis by calculating as a function of various kinetic and equilibrium parameters.
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PMC11216402
ENCODE DNase-seq and TCGA STAD ATAC-seq (Corces et al. 2018; Shigaki et al. 2019) were processed in a similar manner, as described previously (Shigaki et al. 2019).
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PMC9739791
The role of excited singlet and triplet states of Phorbiplatin 8 in the photoreduction mechanism was studied by observing the differences between PPA’s and Phorbiplatin’s spectral features using TCSPC and transient absorption (TA) spectroscopy respectively.
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PMC11269933
However, despite extensive phosphoproteomics studies revealing diverse phosphorylation dynamics of glycolytic enzymes in response to stress, reliable characterization of the impact of these phosphorylations on enzyme properties has been limited to only a few studies in plants and model organisms, with no corresponding research conducted in marine organisms.
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PMC11252553
Based on the analysis, the quadrants were identified as follows: 1) lower left quadrant, with positive cells for both Annexin V and PI staining, 2) lower right quadrant with positive cells for Annexin V staining but negative for PI staining; this quadrant represents early-apoptotic lymphocytes, showing cells with externalized phosphatidylserine and intact cell membranes, 3) upper right quadrant, with positive cells for both Annexin V and PI staining with late-apoptotic lymphocytes, indicating cells with further progression in the apoptotic process and compromised cell membranes, and 4) upper left quadrant, with negative cells for Annexin V staining but positive for PI staining.
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PMC9429973
Markers of immune exhaustion including PD1 and PDL1 were increased on T cells, CD11b+, and lymphoma cells in MCL burdened mice.
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PMC11512230
We demonstrated that AltMV SPV after binding to the membrane of target cells penetrates and retains within the cytoplasm.
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PMC11126803
To study the role of LncRNA-SERB, we selected two cell lines, A498 and 786-O, as experimental subjects.
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PMC11653533
Again, its leaves are used in jaundice and as an antidote for snakebite; fruits are used in stomach pain and tuberculosis, and finally the whole plant is used in respiratory issues and several skin problems (Erhirhie et al., 2018, Maregesi et al., 2007).
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PMC6163708
Three cell lines were nontransformed and tested for comparison with tumor cells (HeMN-LP, IMR-90, and WI-38).
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PMC11506670
No. CCL-247) and the HCT116 human colorectal carcinoma cell line (Cat.
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PMC11012012
Korver et al. (2007) reported that SLAMF6/CD352 expression levels were found to be higher in B cells obtained from both CLL patients and normal volunteers compared with NK and T cells (as assessed by flow cytometry).
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PMC11680982
Neratinib enhances the efficacy of CDK4/6 inhibitor combined with endocrine therapy in HR/HER2-low breast cancer in vivo. (
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PMC9848491
ROC, receiver operating curve; AUC, area under the curve; OS, overall survival; TCGA, The Cancer Genome Atlas.
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PMC9100622
Bayesian Student’s t-tests were performed using the Limma R package.
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PMC11763764
We demonstrated the molecular mechanism by which SORL1 enhances cancer cell proliferation and platinum resistance through stabilizing the receptors of several growth factors.
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PMC9727330
The mRNA expression level of Caps3 gene was quantified as indicated by fold change in treated Caco-2 cells compared with untreated cells (N.T.) and DMSO-treated cells.
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PMC9024365
Neurons were then stained for total anti-SD4 and total anti-vGlut1 overnight in 3% BSA at 4C.
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PMC9164404
Finally, a multi-omics strategy, including transcriptomics, metabolomics, and lipidomics, was carried out on BEL-7404 cells to elucidate the molecular mechanism of Abplatin.
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PMC11388384
After ~18 h, Halo-ligands (JF549i or JF635i, gifts from Luke Lavis) were added to a final concentration of 50 nM, and incubated at room temperature for 5 min.
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PMC9429973
Methods: The data of 207 patients with t(8;21) AML was retrieved from Sino-us diagnostics lab from June 2015 to October 2021.
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PMC8357004
To determine the relative expression level of p16INK4a, p14ARF, p15INK4b gene, qRT-PCR was done.
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PMC9429973
Methods: This ongoing prospective multi-center registry (NCT03678454) includes ≥18-year-old patients with CML or Ph+ALL eligible for ponatinib treatment per product label.
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PMC11604015
Continuous downregulation of antigens on the cell surface may be caused by antigen internalization, antigen masking, or intracellular sequestration .
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PMC9596868
Data represents mean ± SEM of three or more independent experiments for PA-1, A2780 and OVCAR3 cells and of two independent experiments for OSE cells.
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PMC11342785
TPPP FL, EC50 = 0.54 μM; TPPP-Ccore, EC50 = 1.58 μM; TPPP-Ncore, EC50 = 2.06 μM; TPPP(45–206), EC50 = 10.58 μM; TPPP(45–196), TPPP(45–186), TPPP(20–166), and TPPP-CORE curves and EC50 constants were determined by fitting to a hyperbola.
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PMC11422150
Seven days post-SCI, bone marrow was harvested from normal, untreated SCI, and hAMSC groups and subjected to flow cytometry (Figure 6A).
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PMC3164356
Among the unexpressed genes, the most enriched GO-terms in the molecular function and biological process classes were glycoprotein binding, T-cell activation and macromolecular assembly (Supplementary Tables 15–17).
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PMC11706491
Scale bar = 5 μm. (
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PMC11745600
Kuma mice were generated by introducing a p. Q104del mutation in the Ins2 gene into the BALB/c strain of Rag-2/Jak3 double-deficient mice by using clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9 (CRISPR/Cas9)-mediated gene editing.
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PMC11119602
The results show that TG2 transamidation activity was slightly higher (though not significantly so) in HepG2/cr cells compared to that of parental cells (Figure 2C and Figure 4A).
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