Datasets:
OTAR3088
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BioData-CellLine_annotated

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PMC11782508
Aliphatic protons resonated in the range of δ 0.0-3.4 ppm.
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PMC10877303
This investigation aims to identify potential inhibitors against the 3CL of MERS-CoV by screening 2369 phytoconstituents obtained from Japanese medicinal plants, using an extensive array of in silico techniques.
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PMC11682172
Data representative of two independent experiments. (
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PMC11779993
This antioxidant activity likely contributes to the ability of SPEE to reduce oxidative stress, neutralize free radicals, and chelate metal ions.
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PMC9429973
There were no cases of peripheral vascular disease or strokes.
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PMC11087301
The attributable molecular mechanism was reported to be Akt/mTOR signaling inhibition following AMPK pathway promotion .
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PMC10291556
However, once inside the cell, reactions with intracellular components might be induced, rendering the prodrug biodegradable.
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PMC11680982
HER2 expression in HR/HER2-0 and HR/HER2-low breast cancer subtypes by fluorescence quantitative PCR assay, P = 0.015, *P < 0.05; n = 3.
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PMC11569208
The validation demonstrated that only two hits were able to increase VSV∆51 greater than vanadate: lysosomal acid phosphatase 2 (ACP2) and phosphoserine phosphatase (PSPH) by 19.5 and 17.5-fold respectively (Fig. 2A).
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PMC7215722
Cells were then incubated at 37 ⁰C, 5% CO2.
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PMC9429973
Methods: This is a prospective multicenter observational study conducted in the following 3 University centers in period from 15 March 2020 to 31 October 2021.
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PMC11769516
Also, a previous in vivo study in mice, determining the penetration of BEA and ENN across the BBB, indicated a rapid and large influx of these mycotoxins into the brain of the animals tested .
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PMC11727145
Therefore, we optimized the air-liquid interfacial culture medium composition by simplifying the historical formulation without compromising keratinocyte (therapeutic cell model) viability or proliferation.
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PMC11224020
In tissues, a major physical signal experienced by motile cells results from the shape changes and deformation of internal organelles imposed by the physical constraints that they experience.
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PMC10847511
It has long been well documented that in vivo drug studies using PDX models more closely resemble clinical tumors than in vitro studies with cancer cell lines.
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PMC11204465
The sterigmatocystins and aflatoxins had been shown to be hepatotoxic and nephrotoxic in animals.
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PMC11640247
Statistical significance was determined using one-way ANOVA with Tukey’s post hoc test (p < 0.033).
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PMC2193049
Studies on the degradation of short fluorogenic peptides by purified proteasome in vitro have demonstrated the presence of at least five different enzymatic activities: a tryptic-like activity, cleaving after basic residues; a chymotryptic-like activity, cleaving after hydrophobic amino acids; a peptidylglutamylpeptide hydrolyzing (PGPH) activity, cleaving after acidic residues; a “branched chain amino acid–preferring” (BrAAP) activity; and a “small neutral amino acid–preferring” (SNAAP) activity (10).
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PMC11751675
The authors concluded that endoperoxides, particularly artemisinin (40), exhibit significant efficacy as treatments for hepatitis C and other Flaviviridae viral infections.
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PMC10808409
A group of small non-coding RNA molecules called microRNAs (miRNAs) are found in eukaryotes and are involved in the post-transcriptional, translational, and RNA silencing processes that control the expression of genes.
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PMC9454852
REN cells (500–1000) were plated in six-well dishes and incubated at 37 °C, 5% CO2 for colony formation.
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PMC9429973
The Phase 1b component will define the maximum tolerated and/or recommended Phase 2 dose (MTD/RP2D) of LANRA when added to gilteritinib in accordance with a 3 + 3 dose escalation design.
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PMC11718109
E’ High magnification of boxed areas show presence of clear large vesicles and the occasional presence of DCVs that were positive for VMAT2-GFP signals.
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PMC11534035
Via unpaired t-test, statistical analysis of quantified western blots was used to determine the relative protein expression of PAI1 in the SERPINE1/PAI1 knockdown group compared to the siRNA control in A431 cells (Figure 4A).
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PMC9325715
However, the models can be applied only to isotherm type I, which corresponds to the first step of the IV/VI type isotherm.
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PMC10440586
To address this problem, patient-derived xenograft (PDX) models need to be constructed to observe the recruits of TME cells in vivo.
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PMC9429973
Based on the percentage of CD34+VEGFR2(CD309)+ endothelial cells (ECs) in bone marrow (BM) detected by flow cytometry at 14d before conditioning, patients aged 15 to 60 years with acute leukemia undergoing haploidentical HSCT were categorized as low-risk(EC≥0.1%) or high-risk(EC<0.1%); patients at high risk were randomly assigned(2:1) to receive NAC prophylaxis or nonprophylaxis.
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PMC11201245
After another wash step in 2×SSC, 0.1% Igepal for 1 min, the slides are dehydrated in an ascending alcohol series (ethanol 70, 90, and 100%) and air-dried.
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PMC2192239
Incubation of isolated Ets-1 protein with purified CaM kinase II produced phosphorylation of peptides that migrated identically to those found in cells incubated with either anti-IgM or ionomycin.
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PMC9024365
Therefore, signal is only present when the N-terminus is expressed.
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PMC11787381
Route of administration: Intra-nasal, in one nostil.
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PMC8584666
Among the multiple tumor cells that were examined, PC-3 cells were able to confirm the most stable expression level of GPI-80 by flow cytometric analysis.
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PMC11515150
Jurkat cells were incubated away from light with blank control, 5D-His and 12 C-His at 4℃ for 30 min, two of each group and a total of six groups.
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PMC6835762
The subsequent “click” coupling of PEGylated chains led to hybrid materials able to form worm-like nanoaggregates .
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PMC11082662
Subsequently, primary cells were isolated from the ovarian cancer tissues and cultured for 0.5, 1, 2, 4, and 8 hours, after which the supernatant was collected to extract exosomes for the assessment of SMPDL3B protein levels via Western blotting.
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PMC11788920
By using a modified version of Cas9, called nuclease-deficient Cas9 (dCas9), this system can be adapted to target genomic DNA without cutting it , as demonstrated by mutating the Histidine-Asparagine-Histidine (HNH) and RuvC nuclease domains of the Streptococcus pyogenes Cas9 .
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PMC6379402
We also use the same clustering and enrichment analysis methodology to assess the utility of integrating all of the data networks, PPI, COEX, and GI.
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PMC9429973
Exposure of human neoplastic T cells (Jurkat and MOLT-4) to STP938 resulted in concentration dependent induction of cell death (Figure C).
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PMC7348793
These primers were tested on COS-7 genomic DNA, the PCR fragment was cloned, sequenced, and the sequence matched that of NC_02657.1.
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PMC11676674
Therefore, the IC50 value obtained from our extract falls within the range reported for other Cistus species.
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PMC9985266
According to previous reports , 4% formaldehyde was used to fix cells, and the cells were disrupted by ultrasonication.
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PMC9429973
Two patterns of chromothripsis-related rearrangements were identified: one clustered in the chromothriptic region (3/9) and the other involving both chromothriptic and non-chromothriptic chromosomes (range: 1-6 chr) (6/9).
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PMC9429973
Results: BL pt characteristics, including body mass index (BMI) and CS dose, were generally balanced between groups—median BMI (RUX vs BAT): responders, 22.7 vs 23.3; nonresponders, 22.4 vs 22.1; median CS dose (mg/day, RUX vs BAT): responders, 30.0 vs 30.0; nonresponders, 33.9 vs 35.0.
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PMC11509224
The results indicate that these are promising antiallergic lead compounds.
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PMC7602170
PI3Ks are considered to have three sub-classes named class Ι, II and III .
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PMC11767582
5-(2-nitrophenyl)-1-(3,4,5-trimethoxyphenyl)-1H-1,2,3-triazole (3c): Starting from 1-ethynyl-2-nitrobenzene (74 mg, 0.5 mmol) and following the general procedure described before, compound 3c was purified by chromatography, eluting with n-hexane-EtOAc (1:1).
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PMC11742231
The output of the Sigmoid function represents the control gate weight, which is then used to modify the two-view features.
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PMC10047551
To address the eventual existence of additional PD-L1 CpG sites with methylation levels correlating with the mRNA expression observed in NSCLC, we screened a previously generated dataset including genome-wide information on DNA methylation (Infinium MethylationEPIC 850K array) and mRNA expression (RNA-sequencing) from a group of five isogenic HCC827 cell clones .
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PMC11394730
These outcomes were validated with an AhR inhibitor (CH223191), showing a rise in the cell survival rate.
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PMC11473750
Cells were then treated with 100 µg/ml CHX for up to 30 min followed by immunoblotting of total cell lysates with anti-RNF121 or anti-MYCN antibodies.
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PMC9429973
At a 5-year median follow-up, we report the final results of this trial.
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PMC8143558
Leaves, twigs, roots, stem barks, fruits, seeds, and flowers of these plants are rubbed or agitated in water, forming a stable lather, which is then used for washing, bathing, and hair shampooing.
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PMC8557138
Failure to re-establish a functional vasculature due to inadequate angiogenesis results in ischemia, causing permanent damage to the affected tissue, compromising its functionality (Chertok et al. 2019).
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PMC11075223
distributed in Sichuan, Xizang of China), Cimicifuga nanchuanensis Hsiao. (
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PMC9429973
No correlation between BDNF and expression or response in PAC1 and CD63 was observed.
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PMC11779605
Equal serum volumes or protein lysate concentrations were placed in duplicate wells of the 96-well plate of the FGF7 ELISA Kit (Cat. #
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PMC11697065
Digestion was stopped by the addition of trifluoroacetic acid (TFA) to a final concentration of 0.5 % (pH 2–3) and RapiGest was degraded by heating at 37°C for 45 min.
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PMC11746942
E Immunofluorescence staining of S1PR3 (red) in patients before and after psoriasis treatment.
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PMC6799808
Hence, it will be interesting to determine whether GLPT inhibits mTORC1/2 signaling by increasing the intracellular levels of ROS, calcium or both.
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PMC9318744
Antiviral strategies are a promising alternative; thus, our aim was to establish a reliable cell culture system for accelerating the discovery of novel antiviral drugs against SARS-CoV-2 and its variants.
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PMC11406030
In this study, we tested the safety and efficacy of LMTK3BP #1 and #2, since they displayed the highest affinity for LMTK3.
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PMC11783017
Previous studies have reported that MYC amplification occurs in close to one-fourth of OS patients.
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PMC11371627
Other antinuclear antibodies, antineutrophil cytoplasmic antibodies and rheumatoid factors were negative.
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PMC10748106
These Genipin derivatives are comprised from D1-D8, and D12-D26.
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PMC10777969
Based on our prior research, this motif appears to aid the transfer of FCP into cancer cells, where it is degraded/hydrolyzed under cancer-cell-specific conditions (pH) and enable the thiazoline pharmacophore to interact with intracellular thiols via its sulfur moiety.
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PMC11297139
f Representative confocal images of the Corelet system using PrLD1-mch-SspB or PrLD1-Pfam-mch-SspB to observe recruitment of BAF complex subunit upon blue light stimulation.
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PMC11451940
In the meantime, Cu(NO3)2·3H2O (20 mg, 0.089 mmol) and the terpyridine (20.8 mg, 0.089 mmol) were dissolved in a MeOH/H2O mixture (1 : 1 v/v) in a 1 : 1 molar ratio and stirred at room temperature for 1 hour, giving a light blue solution.
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PMC9429973
Of the 236 studies, 82 were considered relevant.
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PMC8009078
After molecular docking and in-silico pharmacokinetic analyses, they were found two promising molecules.
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PMC10329074
P < 0.05, **P < 0.01, ***P < 0.001 In order to analyze the clinicopathological variables, a total of 265 ccRCC samples with low YBX3 expression data, as well as 265 ccRCC samples with high YBX3 expression data, were analyzed (Table 1).
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PMC11033180
Data are mean ± SEM, n = 8 cultures from 2 independent experiments.
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PMC11676670
One of the main genetic features of HGSOC is mutation in the TP53 gene and pronounced genome instability.
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PMC11634794
Immunohistochemistry analysis revealed an increase in both the percentage of LAMP1-positive tumor cells and staining intensity with increasing tumor grade (18).
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PMC11224020
RNA-seq libraries were prepared from 300 ng to 1 µg of total RNA using an Illumina TruSeq Stranded mRNA Library Preparation kit and an Illumina Stranded mRNA Prep Ligation kit, which allowed strand-specific RNA-seq.
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PMC8996378
Some new diterpenes were isolated from the whole plant of Euphorbia peplus and their inhibitory activity to ABCB1 was investigated in ABCB1-overexpressing K562/R7 human leukemic cells (Table 1).
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PMC11342785
Free microtubules are shown as a negative control.
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PMC9429973
Among patients with TD BT, 90/118 (76.3%) were receiving transfusions at least once every 4 weeks, with 5.1% receiving transfusions weekly, 16.1% every 2 weeks, 28.8% every 3 weeks, 26.3% every 4 weeks, 3.4% every 5 weeks, 17.8% every 6 weeks, and 2.5% other or unknown.
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PMC11775197
PPARα is highly expressed in the liver, kidney, intestine, heart, skeletal muscle, and brown adipose tissue [18–20].
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PMC11046454
Only upon exposure to high-concentration ATP, ATP-AptPTK7 could switch into a valid configuration for specific binding against PTK7 cells (Figure 4B, S34, and S35).
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PMC9429973
This difference was relevant in patients with chronic heart diseases (p=0.005).
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PMC11186948
Acetylation of lysin 27 of histone 3 (H3K27Ac) normalized on unmodified lysin 4 of histone 3 (H3K4) (H3k27Ac/H3K4, on Y-axis) in LCLs derived from five healthy donors (HD, grey bar), three RSTS patients with mutation in CREBBP (CREBBP, orange bar) and patient #249 (red bar) (on X-axis), assessed by AlphaLISA assay; variance of means of histone acetylation values of the three groups was compared using one-way ANOVA. (
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PMC11509278
The survival rate and metastasis of A431 cells are inhibited when MMP9 in the A431 cell line is inhibited by CRISPR/Cas9-mediated transfection of guide RNA (gRNA), which causes a decrease in viability, migration, and the mRNA expression levels of the oncogenes TGF-β, FGF, PI3K, VEGF-A, and vimentin .
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PMC7433824
Indeed, there was some activity of mifepristone to reduce growth stimulation mediated by low dose (10 nM) of P4 albeit at concentrations 1000 times higher than P4. , , ,
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PMC9693627
Thus, the expression of PTCD2 gene in cells with a deletion led to the restoration of the phenotype, which indicates the specificity of the observed decrease in COIII translation.
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PMC11708541
The biotesting phase of thiourea derivative 62 was conducted to determine its mode of inhibition of specific transcriptase types and its potential as an anti-HIV agent.
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PMC9429973
BCL2L12 is a prominent member of the apoptosis-related BCL2 family, with an already established role in AML.
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PMC6450504
However, in our study, we evaluated the in vitro drug release at different pH conditions (Figure 1(e)) to also investigate this parameter’s relevance to the therapeutic applications and in vivo physiological environment that the liposomes would be exposed to.
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PMC11290772
A portion of fresh tumor tissue was collected for immunohistochemistry detection before the generation of primary tumor cells and tumor organoids.
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PMC9220170
Staining of the grown colonies was carried out as follows: 1 mL of PBS containing 4% formaldehyde and 0.005% Crystal violet were added over the top layer of agarose, draining the culture medium beforehand, incubated for 2 h, rinsed the dishes from the dye, and counted the colonies.
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PMC9429973
Prior to randomization, an open-label safety run-in was conducted; pts received BV (1.2 mg/kg) and rituximab (375 mg/m) both q3w, and len 20 mg qd.
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PMC11612508
6H2O were dissolved in deionized water in a mole ratio of 1:2.
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PMC9581083
Quercitrin is an important flavonoid glycoside in H. cordata (Li et al., 2011), capable of inhibiting the cellular content of murine Broncho alveolar fluid in mice with LPS-induced lung injury (Wu et al., 2009).
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PMC11754432
Two-way ANOVA or one sample t test (A) performed; significance denoted by *P < 0.05, **P < 0.01, ***P < 0.001.
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PMC11803918
First, γδ-T exosomes and Ce6-loaded liposomes were mixed at a 1:1 (w/w) ratio and processed through freeze–thaw cycles.
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PMC11786156
CD54 and CD11a were simultaneously expressed (double-positive) in extra/intravascular tumor cells in 14 (35%) of the cases.
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PMC9429973
One patient died of an E. coli sepsis not considered related to RG6234.
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PMC11409031
Evading apoptosis is a critical feature of cancer, as cancer cells can create ways to escape apoptosis and boost their survival, growth, and resistance to therapy .
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PMC9920575
Some hallmarks of cancer are uncontrolled growth and apoptosis evasion , which are the major hurdles in defeating cancer.
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PMC11495567
The 8-well μ slide plates (ibidi) were incubated for 1 h at 37°C under 5% CO2.
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PMC9509578
Several factors are involved in the development of MDR including increased expression of efflux transporters, the tumor microenvironment, changes in molecular targets and the activity of cancer stem cells.
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