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PMC9429973
Thus, we have generated a nanoparticle (T22-PE24-H6) that selectively delivers the exotoxin A from Pseudomonas aeruginosa to CXCR4 leukemic cells.
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PMC11721587
This blockage was alleviated by coexpression of Fu but not by Fu or Fu (Fig. 1L), suggesting that Fu provided a noncatalytic activity to expose S218/S220 and S1382 masked by Sufu binding.
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PMC5261804
We analyzed α = 0.9, 0.5, 0.1 and we observed that the smoothing parameter doesn’t have a significant effect on the ranking of essentialities.
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PMC11422497
KIT act as oncogenic role in GISTs. (
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PMC7090062
e, f The cell proliferation was measured by EdU assay. *
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PMC5415764
After various LPNs were incubated in A2780/PTX cells for 1 h, the amounts of Rho 123 accumulating in cells after various treatments were shown in Fig. 3B.
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PMC11752740
Following this, we conducted combination therapy analyses to assess the potential synergistic relationship between Pistachio hull extract and CFZ after 24- and 48-hours of treatment on both the SK-BR3 breast cancer cell line and the MCF10A normal cell line.
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PMC9429973
Overall survival (OS) and progression free survival (PFS) curves were estimated using the Kaplan-Meier method and were compared using the log-rank test.
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PMC11297139
The representative images supported by the relevant statistics have been chosen upon three independent preparations with similar outcomes.
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PMC10852540
High-Capacity cDNA reverse transcription kit (Life Technologies, United States of America) was used at this stage.
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PMC11477621
The crude product was purified by silica gel chromatography to give the light brown solid (243 mg, 51%).
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PMC9429973
Summary/Conclusion: In this cohort of 454 CEBPA mutated adult AML pts, CEBPA was associated with specific clinical and genetic characteristics.
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PMC11798926
The mean value of all the control samples was then used to normalize all the values within a given experiment.
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PMC11798926
For mouse cultures, DIV18 hippocampal cultures were live-fed the previously listed anti-Flag antibody for 10 min at RT, followed by a 10-min incubation of the secondary antibody (Invitrogen Goat anti-Mouse IgG1 Alex Fluor 647 Cat#A-21240; RRID: AB_2535809).
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PMC9848491
To evaluate the predictive signature predicting treatment response to UCEC, we calculated the median maximal inhibitory concentration (IC50) for 138 common clinical chemotherapy drugs.
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PMC6442998
Primary antibodies raised in different species and secondary antibodies coupled with different fluorochromes, were sequentially combined to specifically label one marker in green (800 Li-Cor), the other in red (680 Li-Cor).
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PMC10999934
3Cell annotation and KEGG analysis in the GSE154600 dataset. (
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PMC11791264
Each bar represents the mean ± SD (n = 3).
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PMC11655498
In epithelial cells, ΔNp63α maintains EBV latency, while in Burkitt lymphoma, TAp63α restrains the activation of EBV.
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PMC11092382
This formulation has been developed for for rectal administration and is marketed in China as a therapeutic option for chronic pelvic inflammatory disease.
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PMC9454178
A Images of subcutaneous tumours from the vehicle or THZ1 treatment groups (n = 5).
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PMC7868205
At a concentration of 2.5 μL/mL of the AgNPs-containing hydrosol, 100% inhibition of HEK-293 cells and 75% inhibition of the HeLa cells were observed.
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PMC6181431
Interestingly, Hsieh et al. reported that PBRM1 mutations were associated with longer progression free survival (PFS) in metastatic RCC patients treated with first-line everolimus in the RECORD-3 trial .
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PMC8864075
E,F) reTFAE inhibited A549 cells’ migration (n = 3).
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PMC11320834
Combination indices, CI < 1, CI 1, and CI > 1 indicate synergism, additive effects, and antagonism, respectively.
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PMC8750422
In the present study, we elucidated the mechanism of the GPR87-AKT-eNOS-NO pathway for the first time in lung adenocarcinoma; however, further studies are needed to determine whether the GPR87 pathway is the same in other types of cancer.
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PMC9024365
We observed altered distribution of the receptor only when the entire membrane, S2, and CT domains (GluK2/A1/M1-3/S2/M4/CT) were present and co-localized with SD4 in COS cells.
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PMC11139449
A manual selection system was employed to streamline the process of single-cell cloning.
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PMC11401358
and (J) Representative negative staining of the SF nanofibre-like and microsphere-like oligomers before and after oxidation, respectively (Scale bar = 50 nm). (
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PMC10850553
Total RNA was then purified from treated cells subjected to quantitative RT-PCR analyses to examine the induction of C5ar1.
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PMC11499381
This reduction in Emax could have physiological relevance, as both CLR and CTR can interact with RAMP2 and RAMP3, and CTR can signal alone.
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PMC5034105
An important implication of this finding is that kidney transplant donors in ZIKV-affected regions should be tested for the infection before organ donation, as virus shedding in urine might be prolonged.
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PMC7452526
Fresh and healthy Eucalyptus Camaldulensis leaves (ECL) were collected and cleaned with distilled water to remove all the dust and unwanted visible particles, then dried to constant weight at 60 °C for 2 h to remove the residual moisture.
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PMC8193813
CEMSs on the boiler stacks produced a continuous record of NOx emissions and O2 concentrations.
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PMC11774747
Landmeier reported that CAR-VZVST re-expanded after re-exposure to booster doses of a VZV vaccine (95).
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PMC11705862
In (D) representative images of the CA1 region in three T2D cases and three NC are shown (Group 2).
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PMC11670407
However, OTULIN overexpression did not reverse the increase in cleaved caspase-3 levels induced by cisplatin in GPX4-knockdown cells (Fig. 6h, i).
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PMC10898159
HSP 90 inhibitors, IPI-504 and AT13387 can decrease the KIT protein level, showing obvious antitumor activity in GIST as a single agent, and they are more potent when in combination with IM or sunitinib .
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PMC7294030
These results indicated that in-vitro treatment of aurisin A against this human lung cancer cell line inhibits cell proliferation and migration, and induces apoptosis and cell-cycle arrest.
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PMC11665584
Finally, neither the proportions of Vascular Smooth Muscle (Myh11, Tagln, Acta2) nor Skeletal Muscle (Mylpf, Tnnc2, Tnni2) cells significantly changed across the samples (Supplemental Figure 7E).
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PMC11708541
To estimate viability, trypan blue was utilized.
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PMC11750712
Each patient goes through the following five steps:Screening stage consisting of TRBC1 screening and eligibility inclusion/exclusion criteria assessment.
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PMC9429973
These were then grouped into themes, and reframed to create individual non-overlapping topics.
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PMC11552389
Next, transfection efficiency was assessed by treating cells with FOXN3 expression vectors or targeted shRNAs (shR1 and shR2), then analyzing the resulting by Western blots.
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PMC8584666
In this study, the proliferation of GPI-80-expressing cells was significantly suppressed by the addition of low-dose N-acetylcysteine (0.3125 mM) (Figure 3d).
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PMC8348645
The concentrations of Withania somnifera extract and standard doxorubicin were taken as 80 µg/mL, 160 µg/mL, and 25 µM including control, respectively.
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PMC10823017
The inhibition of aPKCs and downstream effector proteins by combination therapy is more pronounced compared to a single therapy.
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PMC11786767
To establish and characterize Ki-67 knockdown, we designed a plasmid expressing an artificial miRNA, Ki67-miR, to downregulate endogenous Ki-67 in COS-7 cells.
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PMC10362265
The residue index was set according to the 7al7 structure.
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PMC11486946
The EGF dose-response curve was fitted with the Hill equation as follows:7[12pt] $$= -}_})}^}.$$=min−max−min1+EC50Lh.
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PMC9587298
However, Jiménez-Aspee, Theoduloz, Ávila, Thomas-Valdés, Mardones, von Baer, et al. (2016) demonstrated that Chilean wild raspberry protected epithelial gastric AGS cells against MGO not by trapping MGO, but by increasing the intracellular levels of reduced glutathione (GSH).
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PMC11680982
This study examined the expression of Cyclin D1 and CDK4, key proteins involved in cell cycle regulation, revealing that knocking down HER2 in HR/HER2-low breast cells cancer blocked the G1 phase and downregulated Cyclin D1 and CDK4.
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PMC11767817
Based on our previous studies, we selected two compounds, known as 2a and 2a-B, as their effect on cell viability is more potent than that of curcumin.
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PMC5025404
Currently, adalimumab (otherwise known as Humira) is the representative TNF-α blocker for the treatment of rheumatoid arthritis (RA) and other common inflammatory arthropathies (Furst et al. 2007; Nasonov 2007).
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PMC9780037
When cyt c binds to the aptamer, its heme transfers electrons to the electrode, generating an electrical signal (Figure 2B).
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PMC8073654
Compound 1 inhibited the platelet aggregation induced by collagen, adenosine diphosphate (ADP), AA, and the platelet-activating factor (PAF) with IC50 values of 0.35, 4.85, 0.94, and 1.14 mM. The anti-inflammatory activity of (E)-1-(3′,4′-dimethoxyphenyl)but-3-en-2-ol (17) has been investigated in several in vivo models .
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PMC11659734
These common training modules complemented the ‘learning by doing’ fellowship realised within the consortium between the two article 36 organisations, i.e. NILU and ISS.
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PMC9429973
Median number of pathogenic mutations was 1 (range: 1-4) in both SVT+ and SVT- groups.
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PMC9672323
Heparinized peripheral blood was collected from 5 healthy volunteers and PBMCs were separated using a density gradient centrifugation protocol (Ficoll paque, sigma, USA) by a standard procedure.
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PMC6650823
Medicinal chemistry efforts to find new low-cost strategies against the “Big Three” are not merely significant, but unquestionably urgent.
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PMC11684269
Lipid dysregulation is a significant manifestation in renal diseases, and the following lipid accumulation in renal tissue exacerbates existing kidney damage, which is termed lipotoxicity (93, 94).
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PMC6742971
Once the Me275 tumors became palpable at around D23 post tumor engraftment, 1 × 10 of a high avidity T cell clone, a low avidity T cell clone, or a 1:1 mixture of the two clones were injected intravenously in the tail vein (100 μl PBS) of mice.
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PMC9917080
An increase in the time of incubation of A-172 cells with SeNPs up to 48 h led to an increase in the apoptotic effect of nanoparticles.
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PMC9065483
Relative gene expression was normalized to GAPDH, and fold-induction calculated relative to an uninfected and untreated condition.
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PMC11653168
All experimental protocols were approved by the Animal Care and Use Committee of the Taichung Veterans General Hospital (IACUC no. La-1132052; Taichung, Taiwan).
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PMC9429973
These findings further highlight the importance of shared decision-making between clinicians and patients to ensure the prescribed TPO-RA has the best impact on patients’ quality of life.
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PMC11775197
It inhibits apoptosis and inflammatory bowel disease (IBD) in the mouse colonic epithelial cell line M064 through PPARα inactivation .
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PMC11321678
Mouse brains were collected and fixed by perfusion with PBS and 4% paraformaldehyde.
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PMC6461034
Therefore, experimentally established kinase–substrate relationships listed by PhosphoSitePlus (Hornbeck et al, 2015) are used to link substrate‐associated spectral counts to specific kinases, followed by kinase ranking.
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PMC9684669
The gene ontology (GO) enrichment study revealed 13 calcium-related biological processes which caught our attention ( Figure 4B ).
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PMC11777207
The cells were pelleted and washed before staining for flow cytometry.
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PMC11732635
Regular virus level checks showed that the EBV-DNA count remained undetectable (Figure 3).
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PMC11297139
n = 10 technical replicates of spheroids.
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PMC10158546
When examining fluorescence signal intensity, we found ReN 129 M spheroids to express higher levels of GFAP, PrP and TUBB3 compared to WT and KO (Figure 5d).
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PMC6617630
Combining SAHA with I-BET further reduced the proliferation in U2932, LY1, and Val with WT-MYC, DHL, and THL status, respectively (Fig. 7a–c).
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PMC11507371
Ten images, each containing approx.
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PMC11087301
A thorough understanding of the processes that govern the balance between EMT and MET in malignancy is crucial.
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PMC11675244
Such mutations also occur in other cancers, including hepatoblastomas and hepatocellular carcinomas (HCC) , and APC and β-catenin mutations have been found together in the same tumor .
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PMC9429973
The strongest predictor of ex vivo drug sensitivity is the sample composition as captured by the PhenoGroups, which we find is also reflected in the clinical course.
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PMC11337594
Cells were exposed to different doses of TER (1.0, 2.0 and 3.0 µg/ml), and SDS‒PAGE and protein blotting were performed to detect the protein expression of p53 and CyclinA2 as well as the cleavage of PARP1, CASP3, CASP7 and GSDME (n = 3). (
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PMC11762280
The above results suggest that UVB irradiation induced an increase in epidermal cell death and infiltration of immune cells including neutrophils and macrophages after UVB irradiation.
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PMC11323699
Conversely, sagittal diameter measurements were found to be a less reliable indicator of tumor load (Suppl.
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PMC11737091
Colony formation assays were also conducted in vitro to assess tumor cell proliferation.
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PMC11001582
WT (n = 4 mice), (GR)400 (n = 5 mice), (PR)400 (n = 6 mice); two-sided Welch’s t-test with 5% FDR multiple-correction.
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PMC11596967
A leucine-rich peptide backbone functions as a bridge, connecting the Gramicidin-S-derived scaffold and TEMPO, facilitating the direct targeting of mitochondrial membranes .
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PMC11772585
Of these genes, we observed a significant decrease in glycolytic metabolism-related genes in METTL1-knockdown HSC-1 cells, including ATF4, HIF1α, MYC, STAT5A, STAT3, SLC2A1, SLC2A3, PKM, LDHA, and ENO1 (Fig. 5B).
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PMC11367146
2 Vanda tesselata extract (VTE)and osteoarthritis (OA) targets. (
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PMC9429973
Predictive factors of RR identified in our study are the same than the factors reported in the literature in addition to age, B symptoms, advanced stage of the disease and bulk.
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PMC9429973
Aims: This study aimed to assess the impact of AF on clinical and economic outcomes in CLL patients.
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PMC10237474
Zoom-in traces are also shown. (
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PMC8728081
This observation suggestes that there was no (or less minimally) soluble mercury (or organic mercury) released from Kajjali and Rasasindura to the larvae medium (water) that could induce toxicity to the larvae.
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PMC11306019
Pyrogallol can be considered to have two VDMs, but the central hydroxyl group is shared.
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PMC9221284
Furthermore, c-Myc2 is predominant in growing cells while c-Myc1 is preferred as cells approach high-density growth arrest .
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PMC11597167
Additionally, quercetin was observed to occupy a similar binding site with oleuropein and interacted with the G34, V69, I126, and Y198 residues through H-bonding.
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PMC9739791
Those reports illustrate the synthetic versatility of bodipy-based photoabsorbers that could be used as a ligand for light-activated Pt(IV)prodrugs.
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PMC9429973
The root cause of SCD is polymerization of sickle hemoglobin (HbS) upon deoxygenation, resulting in poorly deformable sickled RBCs with a shortened lifespan.
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PMC11704135
A mixture of benzothioate derivatives (3 mmol), hydrogen peroxide (5 mL, 50%), and glacial acetic acid (20 mL) was stirred at 25 °C for 24 h. Then after, the solvent was removed using a rotary evaporator at 40 °C under reduced pressure.
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PMC9429973
Immunotherapeutic treatment intensification using blinatumomab (n=5) or inotuzumab ozogamizin (n=1) and / or allogenic stem cell transplantation (n=7) in MRD poor responders or relapsed cases resulted in an overall survival probability of 80% (+/- 12%) vs. 73% (+/- 2%; p=0.07) in the remaining cohort.
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PMC10589262
1Mutant KIT (MT-KIT) and wild type KIT (WT-KIT) show perinuclear Golgi and membranous expression patterns, respectively.
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PMC11607638
To date, only limited works have been done to elucidate the function of SK receptors (SKR) in the context of insect food intake.
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