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OTAR3088
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BioData-CellLine_annotated

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PMC4485786
In summary, our data show that the targeted delivery of IL-12 to the tumor microenvironment efficiently arrested the growth of tumors and induced differentiation beyond its cytolytic function, and provide the first in vivo evidence that the previously described p16 pathway and p53-independent p21 are operational in therapeutically induced cancer control.
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PMC11180402
F-I The invasion and migration abilities of 5637 (nonsense) vs. 5637 (shMMP-2) and 5637 (nonsense) vs. 5637 (shMMP-9) cells, with or without ISO treatment, were assessed (F & H).
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PMC9370419
An analysis of polymorphisms also indicated that individuals with the PvuII T/C genotype of ER-α might be greater virological responders to entecavir than those carrying the T/T and C/C genotypes .
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PMC11802855
A total of 784 NDMM patients with complete prognostic data and RNA-seq data were included in the study.
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PMC9429973
Secondary endpoints were LDH profile over time and number of units of packed red blood cells (pRBCs) transfused throughout the study period, safety, PK, PD, and immunogenicity.
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PMC11737091
The analysis of the correlation between DBF4 and immune modulators suggests that DBF4 may play a role in shaping the immune microenvironment of ccRCC.
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PMC11277157
In contrast, the functional networks presented in this study (Figure 4, Figure 5, Figure 6 and Figure S2) indicate the key role of JAK/STAT as the main hub.
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PMC11711063
After 3 weeks of colony growth, phase contrast images were taken in the 3D stack by widefield microscopy and projected to 2D images to count colonies.
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PMC11532793
RTA-dispersions estimated from kallisto bootstrap samples were highly correlated with those from Salmon, and tended to be intermediate between the Salmon-bootstrap and Salmon-Gibbs RTA-dispersions (Supplementary Figure S1).
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PMC9429973
Interim analyses are planned for ~1 and ~3 years following study initiation to provide an estimate of FLT3 mutation frequencies in the study population, and potentially an early estimate of the rate of clonal evolution.
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PMC11803149
In contrast, genes upregulated by Epas1-Crispr included polo-like kinase 4 (Plk4), which inhibits immune cell infiltration of tumors (44); and GRAM domain containing 4 (GRAMD4), which promotes apoptosis (45).
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PMC11088135
E qRT-PCR was conducted to analyze the mRNA expression of Bax.
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PMC11411131
However, this construct was inadequate because of the low rate of Sec insertion, even in the absence of MeHg.
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PMC9429973
Treatment continued until progression or unacceptable toxicity and was administered i.v.
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PMC11409031
The risk score calculated within this clinical prognostic model was found to be a significant and independent risk factor for predicting clinical outcomes in ovarian cancer patients, according to both univariate and multivariate COX analyses conducted in the training and validation sets.
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PMC11786704
The activation process of the p38 MAPK signaling pathway occurs in the cytoplasm and functions by translocating into the nucleus .
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PMC11297139
The ligated samples were reverse-crosslinked with 2 µg/µl proteinase K, 1% SDS, and 500 mM NaCl overnight at 65 °C.
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PMC10958426
We further identified the DEGs among tumor subclones and found these DEGs had two populations according to CNV-expression correlation.
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PMC11489175
Indeed, besides the key role of USP8 in T cell development and homeostasis 16, USP15 levels have been shown to have an impact on antitumor cells responses, its deficiency being associated with excessive production of IFN-γ, which promotes an immunosuppressive tumor microenvironment in an experimental model of tumorigenesis 137.
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PMC10788478
In our study, when comparing LGR6 expression between spheroid and adherent components of A427 cells harboring a CTNNB1 exon 3 mutation, LGR6 was predominantly expressed in the component of spheroids, which is a CSC‐related characteristic, accompanied by upregulation of several stem cell‐associated pathways and genes, including MMP1, CPA4, and SRPX2.
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PMC11769516
The number of studies focusing on the mitigation of DON-induced cytotoxicity is limited.
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PMC10788478
Both LGR5 and LGR6 are receptors for R‐spondins that control cell stemness in several organs by enhancing Wnt signaling. ,
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PMC11779605
RNA that was isolated from tumor and ascites specimens and passed the quality control testing described above was evaluated for bulk expression analysis using the NanoString Human Signaling Tumor Signaling 360 panel (Cat.
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PMC11224020
We postulate that self-activation of the ARP2/3–cPLA2 axis originates from the successive events of deformation that DCs undergo as they move through the complex environment of tissues.
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PMC5925824
Plates were then incubated for 5 min at room temperature.
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PMC11661040
The results from three independent experiments were summarized in a histogram format. (
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PMC11746948
After scanning, the gel was stained with Coomassie Brilliant Blue (B7920, Sigma) to check for protein loading.
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PMC8633974
TatDE rLNP had a very narrow size distribution with a PDI or 0.045 and size of 76.11nm (figure 9b).
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PMC11666785
The technique has reported volumetric imaging of exosomes labelled with CD63-rsEGFP2 in live U2OS cells.
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PMC11126803
The data used and analyzed in this study are available from the corresponding author upon reasonable request.
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PMC11519567
Scale bars, 5 μm.
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PMC11721587
After sequential incubation with a pair of primary antibodies and corresponding PLA probes (PLUS and MINUS), the cells were further subjected to ligation/amplification reaction.
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PMC10033453
We have previously demonstrated that MorV exhibits a lack of neurotoxicity and hepatotoxicity in contrast to the concerns associated with VSV.
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PMC11611077
To obtain further information on the structure and function of prestin, a method to obtain a large amount of prestin as the material for this research is required.
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PMC11486946
e Time development of MSDs (mean square displacements) for either untreated or gefitinib-treated (10 μM for 1 hour) cells without (black) and with EGF (300 nM, red).
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PMC5916734
The plasmids were linearized with PvuI (p1.1 and p1.2-Zeo) or BspHI endonucleases (p1.2-Hygro), precipitated with ethanol, dissolved in phosphate-buffered saline (PBS), and sterilized by filtration through filters with a 0.22 µm pore size (Millipore, USA).
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PMC8806312
Patient overall survival was notably lower in the high-risk group. (
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PMC11746942
Intriguingly, FTY720 selectively downregulated S1PR3 without affecting S1PR2 expression (Fig. 1G), suggesting that its therapeutic effects were primarily mediated through S1PR3.
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PMC9436459
In this section, we will cover all chemical and chemoenzymatic total syntheses of the MDAAs and their methyl ether derivatives.
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PMC10421378
The cell lysates were centrifuged (10 min, 3.500 rpm), and the pellets were suspended in PBS.
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PMC11541241
Duplications of the TOR protein in these two species may result from independent segmental gene duplication events or whole genome duplication events (Shertz et al., 2010).
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PMC11122631
The COSY spectrum (Figure 4) demonstrated the proton sequences of H2-2 (δH 2.34)/H2-3 (δH 1.72)/H2-4 (δH 2.22)/H-5/H-6/H-7/H-8 (δH 2.55) and H2-13 (δH 2.56 and 2.34)/H-14/H-15/H2-16 (δH 2.00)/H2-17 (δH 1.35)/H2-18 (δH 1.27)/H2-19 (δH 1.30)/H3-20.
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PMC9429973
E. Bachy, K. J. Savage, H. Huang, Y. L. Kwong, G. Gritti, Q. Zhang, A. M. Liberati, J. Cao, H. Yang, S. Hao, J. Hu, K. Zhou, F. Russo, H. Zhang, W. Sang, J. Ji, A. J. M. Ferreri, G. L. Damaj, H. Liu, W. Zhang, X. Ke, C. Ghiggi, S. Huang, X. Li, H. Yao, J. Paik, W. Novotny, W. Zhou, H. Zhu, J. Huang, P. L. Zinzani Hematology Department, Lyon Sud Hospital and Claude Bernard University Lyon 1, Lyon, France; Department of Medical Oncology, BC Cancer, Vancouver, Canada; Sun Yat-Sen University Cancer Center, Guangzhou; Queen Mary Hospital, Hong Kong, China; ASST Papa Giovanni XXIII, Lombardia, Italy; Harbin Medical University Cancer Hospital, Harbin, China; Azienda Ospedaliera Santa Maria Terni, Terni, Italy; Fudan University Shanghai Cancer Center, Shanghai; The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou; Xin Hua Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai; Fujian Medical University Union Hospital, Fujian Institute of Hematology, Fuzhou; Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China; Ospedale Maggiore, Ematologia e Centro Trapianti Midollo Osseo (CTMO), AOI Parma, Italy; Tianjin Medical University Cancer Institute & Hospital, Tianjin; The Affiliated Hospital of Xuzhou Medical University, Xuzhou; West China Hospital, Sichuan University, Chengdu, China; Lymphoma Unit, IRCCS San Raffaele Scientific Institute, Milano, Italy; Institut d’Hematologie de Basse Normandie, Caen, France; Beijing Hospital, Beijing; Peking Union Medical College Hospital; Peking University Third Hospital, Shanghai, China; Ospedale Policlinico San Martino, Genova, Italy; BeiGene (Shanghai) Co., Ltd., Shanghai, China; BeiGene USA, Inc., San Mateo, CA, United States of America; Institute of Hematology “Seràgnoli”, University of Bologna, Bologna, Italy Background: Effective treatment choices for patients (pts) with relapsed/refractory (R/R) mature T- and NK-cell neoplasms after failure of standard therapies are limited.
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PMC9429973
As expected, patients on nilotinib had significantly higher RFI for pSTAT5 compared with rux patients, at 23, 32.8, 21.2 and 46.5 in CD4+, CD8+, Treg and NK cells respectively (p=0.002/p=0.002/p=0.006/p=0.003).
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PMC8316344
Briefly, βTrCP-mediated ubiquitination and followed destabilization of TFRC is essential for TRIB2 to decline labile iron in liver cancer cells.
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PMC11477621
Then, the mixture was stirred at room temperature and monitored by TLC.
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PMC11544771
Data were analyzed using Prism software (Version 9.5) (GraphPad Software, San Diego, CA, USA).
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PMC11529598
Detailed clinicopathological features of the patients in supplementary Table 1.
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PMC11434983
The day after seeding, the medium was removed, and the complexes were added at 1μΜ concentration.
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PMC11422497
Tumor volume was diligently monitored on a weekly basis using the formula V = 1/2×Width×Length.
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PMC9429973
Polynomial transformation and a principal component analysis were used for Logistic Regression.
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PMC10440586
This work mainly used transcriptomic, proteomic, and metabolomic data.
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PMC11244823
To establish negative cut-off values, the average values (AVE) and standard deviations (STD) of the negative serum were calculated and three STD were added to the AVE.
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PMC11703896
Buijsen et al. 2015 reported that a combination treatment of radiotherapy and rapamycin has decreased the metabolic rate of tumour in cancer patients.
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PMC9429973
Summary/Conclusion: In this prospective study, belamaf monotherapy induced rapid, clinically meaningful responses with a manageable safety profile in heavily pretreated pts with RR AL amyloidosis.
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PMC11742231
A multi-channel graph attention module that uses multi-head attention mechanisms with 8 heads in the first layer and 1 head in the second layer, leveraging LeakyReLU activation with a negative slope of 0.2; attention coefficients are computed using shared weight matrices and attention vectors .An adaptive fusion module that concatenates drug representations with cancer cell line and fingerprint embeddings (obtained via convolutional and fully connected layers with ReLU activations), applies a gating mechanism using a Sigmoid function to adaptively weight features and incorporates an attention mechanism followed by a fully connected layer to produce the final output.
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PMC11538390
We identified genome-wide significant (P < 5 × 10) associations with OFC and two genomic loci located on the long and short arms of chromosome 1 (Supplementary Fig. 1a).
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PMC6461034
After injection, peptides are trapped at 6 μl/min on a 10‐mm, 100‐μm inner diameter trap column packed with 5‐μm ReproSil‐Pur C18‐AQ silica beads (120‐Å pore size) in buffer A (buffer A: 0.5% acetic acid, buffer B: 80% acetonitrile, 0.5% acetic acid) and separated at 300 nl/min with a 10–40% buffer B gradient in 90 min (120 min inject‐to‐inject).
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PMC11694625
Weighed the livers, spleens, and kidneys from different groups, fixed them with 10% formaldehyde, then dehydrated them with alcohol, embedded them in paraffin, cut them into sections, stained them with hematoxylin and eosin, and finally observed them under an optical microscope to observe if there were any pathological changes.
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PMC11569208
Schematic detailing the viral backbone of VSV∆51-shACP2. (
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PMC9429973
L. Song, C. Chang Hematology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China Background: Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal myeloid disorders characterized by ineffective hematopoiesis and cytopenias, with variable risks of progression to acute myelogenous leukemia (AML).
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PMC7215722
For this purpose, the level of SI expression in brush border membrane (BBM) or apical membrane preparations (P2 fraction) of DSS-treated Caco-2 cells was compared to that in non-treated cells by Western blotting.
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PMC11247842
Breeding values for Holstein cows were estimated separately for lactations 1, 2, and 3 or higher using a repeatability animal model on SCS test-day records corrected for fixed effect.
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PMC11618052
We refluxed anthranilic acid (1) in ethanol with isothiocyanate derivatives (2a–e) for 8 h. After the reaction was complete (as determined by TLC), the resulting white precipitate was filtered and recrystallized from an ethanol/dioxane mixture (1 : 1), yielding quinazoline-4-ones (3a–e) in 90–95% yields.
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PMC5833712
18S rRNA and Tubulin were used as controls.
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PMC11060216
A majority of S100 genes, located on the human chromosome, 1q21, which is prone to rearrangement, have a close relationship with the initiation and development of many tumor types.
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PMC9429973
As expected, treatment of CRLF2-R DS-ALL PDX models with TSLPRCART potently inhibited in vivo leukemia proliferation and induced long-term ‘cure’ of animals.
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PMC11545737
Meningococci release abundant OMVs, which are important in the proinflammatory response in the early stages of IMD .
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PMC10502403
Heatmap of rank metric scores and plots of the enrichment scores for the “WP oxidative phosphorylation” gene set in the TCR-stimulated state are shown.
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PMC9024365
not significant; *p < 0.05; ****p < 0.0001; one-way ANOVA with post-hoc Tukey’s test.
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PMC9429973
37 patients were admitted to hospital with a median length of stay of 8 days (range 3 -33).
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PMC11765879
Moreover, the molecular pathway investigations pointed out that ZSC extract represses the activity of HER2 and p38 MAPK which could be the main pathways behind the effect of ZSC in HER2-positive cells.
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PMC11802929
Fig. 6Combination of peptide-TCR features associated with cell phenotypes.a We investigated the combination of peptide and TCR properties for antigen-TCR paired SARS-CoV-2 CD8 T cells.
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PMC11761919
The results showed the internalization of PINs into the bacteria promoted bacteria growth, and significantly improved the expression level of Fiber2.
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PMC11676674
Finally, the found micronuclei are assigned to a parent nucleus belonging to the mononucleated or binucleated class.
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PMC11770746
Yield 50 mg (50%).
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PMC11533140
In a pharmacokinetic study, 17p was stable (T ½: 2.03 h) and showed high bioavailability (46.2%).
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PMC7171147
a Flow cytometry analysis of propidium iodide (PI) staining in ES2 cells expressing either scrambled or shCPT1A cultured in COL11A1-positive or negative extract for 48 h and treated for cisplatin (16 µM) for 72 h. Representative flow peak charts are shown on left and quantification is shown on the right.
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PMC5941560
a Total number of merged variant loci called by all tools for different variant types.
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PMC11726848
Images were obtained using the confocal laser scanning microscope Axio Observer Z1 LSM-710 DUO NLO (Carl Zeiss, Germany) (λex 488 nm, λem 493–625 nm) and processed using the Zen Blue software v. 3.0 (Carl Zeiss, Jena, Germany).
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PMC11464982
Food enzyme preparation’ means a formulation consisting of one or more food enzymes in which substances such as food additives and/or other food ingredients are incorporated to facilitate their storage, sale, standardisation, dilution or dissolution.
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PMC6267596
A fluorescently labelled anti-phospho Tyr antibody (PY20) was used to detect the phosphorylation activity of kinases present in the sample and quantified using the BioNavigator 6.3 software (PamGene International B.V.).
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PMC9874064
On the one hand, cisplatin can further cross link with DNA, causing DNA damage.
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PMC11700165
The PH-TH doublet is fused to the major part of the linker-B region.
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PMC11087301
One aspect of debate is whether it is vital for CSCs to go through EMT in order to implant metastases.
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PMC7802142
To label ReN-NV with tdTomato, ReNcells were stably transduced with packaged lentivirus vectors to express tdTomato fused to palmitoylation signal (palm-tdTomato) which labels cell membrane .
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PMC7351993
To form rigid microchannels that avoid potential instability due to flow-induced deformation of microchannels in the chip, we employed 250-µm thick borosilicate glass substrates for the base and cover layers and a 200-µm thick Si substrate for the microchannel layer.
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PMC11286266
Among these, calreticulin (CRT), a key ER luminal chaperone, selectively repressed ATF6α signalling: Cells lacking CRT constitutively activated a BiP::sfGFP ATF6α-dependent reporter, had higher BiP levels and an increased rate of trafficking and processing of ATF6α.
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PMC7723249
Twenty-four hpi, supernatants were removed, cells were washed 3 times with PBS on both sides and then lysed using 300μl of Trizol per well.
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PMC11001582
Genotypes: w; GMR-Gal4/+, w; GMR-Gal4/UAS-daw RNAi, w; GMR-Gal4, UAS-GR36/+, w; GMR-Gal4, UAS-GR36/UAS-daw RNAi.
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PMC9917080
Real-time qPCRs were performed in a 25μL reaction mixture containing SYBR Green I PCR Master Mix (Evrogene, Russia) and 300 nM of the appropriate primers.
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PMC10669966
Moreover, myxoid LPS samples showed elevated expression levels of SLFN12 mRNA.
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PMC11155445
It was concluded that the anticancer activity of these two compounds was found to be time and dose-dependent.
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PMC11334037
Based on the limma R package, a total of 2578 (DEGs 1398 downregulated and 1188 upregulated) were screened out from GEO: GSE225819 data, including 20 normal samples and 20 GIST samples with liver metastasis (|log2FC| > 1; P < 0.05), suggesting that these DEGs may be involved in liver metastasis in GIST patients (Figure 1A).
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PMC7802142
a Immunofluorescence images of Ki67 (green) in HFs from mice receiving depilation and 6-day subcutaneous injection (once per day).
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PMC11607764
RNA-binding proteins (RBPs) meticulously regulate the expression of multiple target genes by controlling various aspects of RNA metabolism, including splicing, transport, stability, and translation.
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PMC8609870
In the study, we constructed a lncRNA-associated ceRNA network to explore the pathogenesis of RSA in 3 patients with RSA and 3 normal abortion patients, providing a theoretical basis for the elucidation and treatment of RSA in the future.
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PMC11352877
Angiogenesis is one of the main signals supporting the survival and development of cells and tissues not only under physiological conditions.
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PMC9429973
ORR for CT in SR2 was 91% vs 70% for NT (p=.48).
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PMC6442998
Viability of GIST882 and GIST48 cells was measured after 24H, 48H and 72H of treatment with a range of verteporfin concentration from 0 to 30μM (Figure 5A).
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