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OTAR3088
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BioData-CellLine_annotated

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PMC11711935
As an effective mitogen, bFGF stimulates melanocyte proliferation and promotes melanocyte migration.
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PMC11462673
A Data from the GEO dataset GSE13159 revealed a significantly higher mRNA expression of LDB1 in T-ALL patients compared to bone marrow samples from healthy donors.
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PMC10788478
UHMK1, which encodes the protein U2 auxiliary factor homology motif kinase 1, is overexpressed in lung adenocarcinomas and functions as an oncogene via activation of the PI3K/AKT mTOR pathway.
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PMC11180402
TK served as an internal control. *
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PMC11765988
Well-formed granulomas result from this cell-mediated response to antigenic stimuli .
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PMC9429973
Results: Overall, 20 variants affecting 9 genes (DNMT3A, ASXL1, JAK2, GATA2, TET2, ETV6, SF3B1, EZH2, KIT) were detected in our cohort; 11/13 (85%) patients showed one or more mutations, with a VAF ranging from 2.6% to 53.0%.
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PMC11335267
From the resulting slice, the ventral hypothalamus was separated by two parasagittal cuts located 1 mm at either side of the midline, and a horizontal cut located at half the dorso-ventral length of the third ventricle.
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PMC9429973
Treatment-related AEs gr ≥3 in >25% of all patients included neutropenia (39%), decreased platelet count (33%), and decreased neutrophil count (28%).
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PMC9429973
Methods: Patients with severe COVID-19 (WHO grade ≥4), confirmed by RT-PCR on nasopharyngeal swabs, were enrolled in the study and received three doses of single-donor CP on days 1, 3 and 5.
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PMC11607764
The cutoff value to separate low or high level of PTBP1 was 50% in this study.
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PMC9429973
Despite WHO listing of HU as essential medicine, it’s clinical use is limited in LMICs with high disease burden.
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PMC6160470
This is in line with Rho123 efflux results, which showed DAC-2Amide to be more effective than verapamil.
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PMC10810426
Integrated MLV was determined in dividing, serum-starved and AZT- or raltegravir-treated cells.
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PMC10877303
Toxicity, which indicates potential damage to cells and organs, is a crucial parameter for drug development .
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PMC11144382
The majority of the examined MSS-associated NFIX mutations did not act via the previously reported target genes, BBX or GFAP, and we therefore hypothesized that other downstream target genes may be involved in skeletal biology.
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PMC11635519
We next screened the peptide library, and the cells were sorted based on the GFP fluorescence.
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PMC11534035
To retain the identity of cell lines, purchased cells were expanded and aliquots were frozen in liquid nitrogen.
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PMC9351137
C To test the effectiveness of ZM447439 inhibition, phosphorylation of the histone H3 (target of Aurora B kinase) during mitosis was evaluated; α-tubulin was used as loading control.
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PMC9429973
Patients with high-risk disease who are ineligible for allogenic stem cell transplantation are treated with hypomethylating agents, including 5-azacytidine (AZA).
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PMC11683240
Values are given as mean ± SEM (n = 8 values from four independent experiments).
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PMC9429973
A hybrid model following the best-fit parametric/spline model to a defined time point and switching to general population mortality was also constructed.
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PMC11638255
Migrated neutrophils were counted using flow cytometry and percentage transmigration was calculated relative to input cells.
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PMC5941560
Each lane of sequencing data was aligned to the hg19 human reference genome using the bwa-mem algorithm from BWA version 0.7.10 with default options .
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PMC10291556
The enzymatic reaction resulted in a colorimetric product proportional to the lactate concentration that was measured at 570 nm with an absorbance reader (SPARK, Tecan).
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PMC11322866
The addition of AG126 restored the uniform distribution of Lamin B1 in the inner nuclear envelope ( Figure 4D).
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PMC11488203
The cell lines were tested for mycoplasma by the luminometric MycoAlert Plus mycoplasma detection kit (Lonza Inc., Rockland, ME, USA) according to the manufacturer’s recommendations.
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PMC10759659
Plasmid psPAX2 (12260; Addgene), pmd2G (12259; Addgene), and ARID1A Knockout lentiviral plasmids were cotransfected into 293 T cells by PEI (Proteintech, #PR40001).
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PMC9429973
They were treated with Aza/Ven as 2 line.
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PMC11546117
The sodium fluorescein leakage reached a minimal value of 0.021 ± 0.009% after 45 days (Figure 3b).
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PMC11583010
Endogenous peroxidases were inhibited by immersing the slides in hydrogen peroxide (H2O2) as part of Roche’s 3,3'-diaminobenzidine (DAB) kit’s protocol.
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PMC9895440
To measure NFAT activation, non-treated flat bottom 96-well plates were coated with 1 μg/ml anti-CD3 (OKT3) or 1 μg/ml anti-CD3 plus 2.5 μg/ml anti-CD28 (CD28.2) in PBS overnight at 4 °C.
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PMC11541409
Glucose mimic 2-deoxyglucose (2DG) inhibits HK activity, thereby disrupting glycolysis.
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PMC9429973
Gene set enrichment analysis (GSEA) indicated that both omipalisib and gedatolisib could suppress “E2F targets”, “Myc targets”, and “G2M checkpoint”, and trigger “TNFα signaling via NFκB”, and “Inflammatory response”.
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PMC3888431
To test this effect, the set of reference mouse proteins was blasted against the translated ORFs of all assemblies and against the protein sequences of the final transcript set.
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PMC9429973
It is characterized by clonal expansion of plasmacytoid dendritic tumor cells expressing specific markers including the interleukin-3 receptor alpha (CD123).
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PMC11772449
HepG2, Huh-7, PLC/PRF/5, BEL-7404, AML-12 and HEK293 cells (ATCC, Manassas, Virginia, USA), fetal bovine serum (FBS; Gibco / Invitrogen, USA), Dulbecco modified Eagle medium (DMEM; Gibco, USA).
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PMC11785489
For example, TCR 1E6 exhibits approximately eight times greater binding affinity to RQFGPDWIVA-HLA-A*02 compared to ALWGPDPAAA-HLA-A*02 (buried surface area: 32,593.7 compared to 3,956.5 Å, PDBePISA).
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PMC11471157
Organization of cell spheroids by MS-1 cells on Day 1.
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PMC9429973
Ten patients had minor response.
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PMC11585994
To form stable nanoparticle complexes, G5 and nucleic acid were mixed at an N:P ratio of 30:1 and vortexed well followed by incubation at room temperature for 15 minutes.
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PMC11545868
Apoptosis and antitumor effect of representative isoflavone glycosides and aglycones.
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PMC3734024
Additionally, we show here for the first time that stimulation with IL-5 and CD40L expanded a population of B cells with potent FasL-mediated T cell-killing activity, and IL-5 enhanced IL-10 secretion from CD40L-stimulated B cells.
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PMC11697065
Fig. 4 Proteomics Analysis from Clonal CHO Cell Lines.
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PMC11700165
The two shorter isoforms of BTK-SYK were detected in the presence of MG132, thus suggesting their rapid degradation in the absence of proteasome inhibition (Fig. 1D).
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PMC11046454
Also, there were no significant differences in body weight (Figure S44) and spleen organ coefficient (Figure S45) among all tested mice.
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PMC11730311
In contrast, we observed a positive association between length of the fatty acid and antagonist potency of hαCGRP8-37.
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PMC7351993
Lohr et al. have used an imaging-based cell picking approach for whole-exome sequencing of circulating tumor cells (CTCs) as a tool for CTC genomics.
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PMC11783017
The orthotopic 143B-bearing tumor model was established by injection of 143B cells into the tibia of Balb/c nude mice.
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PMC11632064
STRING interaction network of the 124 mitochondrial signature transcripts associated with resistance to PLK1 targeting.
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PMC11116779
Data are reported as mean ± SD of at least three independent experiments; p-values are expressed as p ≤ 0.0001, p ≤ 0.001, p ≤ 0.01, and p ≤ 0.05 vs. Control (CTR).
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PMC9429973
Treatment was ongoing for 58.5% of pts at the time of the data cut.
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PMC11754436
Subsequently, the protein expression levels of Bcl2, Bax and caspase 3 were detected in the cells of each group.
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PMC10222971
Derivatives with the most promising results (2-butanoyloxy-1,4-naphthoquinone (4); 5-octoxy-1,4-naphthoquinone (6); and 2-pentoxy-1,4-naphthoquinone (10)) that trigger cell death by apoptotic processes were evaluated on a different tumoral (human melanoma) and non-tumoral (human embryonic kidney 293) cells (Figure 8 and Figure 9).
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PMC11583010
Absorbance was measured at 450 nmol/L on a SpectraMax i3x plate reader (Molecular Devices).
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PMC11468365
The reference model is a model that uses the ‘Loewe additivity score’ that assumes the drugs are not combined with itself.
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PMC9920575
Next, they were fixed with 1.1% glutaraldehyde, stained with 0.1% crystal violet solution (Sigma-Aldrich, St. Louis, MO, USA), washed with distilled water, and solubilized with 10% acetic acid , after which the absorbance was measured at 570 nm using a plate reader (Tecan Spectra, Grödig, Austria).
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PMC11515150
Binding competition studies demonstrated that 5D and 12 C competed for binding to the epitope of CD5 molecule.
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PMC9429973
Relevant clinical and laboratory data, as well as the MPN Symptom Assessment Form (MPN-SAF), are being recorded at the time of study entry.
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PMC9545474
Cells were washed with PBS (1 mL), treated with complexes at 2 × IC50 concentrations or doxorubicin (0.5 μM) as a positive control and incubated for 24 h. Cells were then harvested using trypsin (without EDTA) and stained with PI/Annexin V‐FITC.
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PMC10165258
Although the droplet volume in the current platform is limiting for large spheroids or experimental protocols beyond a few days, larger droplet volumes can be implemented by using larger microfluidic anchors.
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PMC11741577
Statistical analysis revealed significant differences in the expression levels of these growth factors in HMC-1 CM vs. FSL-1-HMC-1 CM conditions (* and ** indicate P < 0.05 and < 0.01, respectively).
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PMC11040965
P ≤ .01, ***P ≤ .001.
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PMC6643347
The fractions were standardized by the characteristic absorption bands in the infrared region (presence of specific absorption bands in the region 2–10 μm) and molar mass distribution (showing a maximum in the vicinity of 7,000 Da).
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PMC9325715
Thus, in case of metal-protein interactions, first adsorption layer may indicate the Fe chelation or nanoparticles formation.
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PMC11481779
The cumulative results of the analysis, as well as an example heatmap, can be seen in Fig. 7.
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PMC11770199
Wong et al. demonstrated that incorporating the p14 protein into oncolytic adenoviruses let to significant improvements in virus replication and spreading in vitro.
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PMC11748335
At the peak level, peaks within H3K9me3 long LOCKs also exhibited significantly higher enrichment in common PMD regions.
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PMC11705547
Therefore, the combination of cisplatin and lipid metabolism inhibitors is a promising new strategy for the treatment of cisplatin-resistant tumors (Figure 4).
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PMC10578720
Citrate synthase/pyruvate dehydrogenase complex hyperacetylation in macrophages after HBV stimulation inhibited their enzymatic activities and was associated with impaired TCA cycle and M2-like polarization.
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PMC3915447
However, the level of caspase-3 and bax proteins was increased in the presence of SPIO dramatically as compared to control group (p<0.05) (Figure 5).
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PMC11632064
I, L): *P < 0.05, one-way ANOVA with Dunnett’s multiple comparison test.
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PMC11705862
The graph in (E, F) shows the significantly lowered IRIS-1 of IRIS-2 immunoreactivity in T2D cases compared to NC (each dot represents the mean value of 6 images with 10–12 neurons used for quantification from every image.
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PMC11271278
HAPI cutoff is defined by the inflection point of each scoring metric.
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PMC9429973
The rationale for the novel enrichment design (Figure 1) of Study ZILO-301 is (1) there is an unmet medical need for pts with R/R MCL that only achieve a partial response (PR) or have stable disease (SD) on Ibr, (2) there is an early opportunity for marketing authorization based upon an accepted surrogate endpoint (namely ORR), and (3) a confirmatory study for regular approval is built into the study design based on PFS.
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PMC8623816
It is worth mentioning that RsRV5-cured strains D122-P derived from protoplast regeneration showed higher virulence on rice leaves, including both more lesion numbers and larger lesion size, compared with the isogenic original RsRV5-infected strain D122 of R. solani AG-1 IA.
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PMC11802855
Our research aimed to identify key genes affecting MM cell proliferation and osteoclast signaling.
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PMC11803149
Flow cytometry analysis of expression of CD62L and CD44 in OT-I T cells (gating strategy is shown in Supplementary Figure S4C ) was conducted every other day between day 2 and day 8.
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PMC11499381
Our results suggest that BiFC methodologies can be applied to the receptor N-terminus, thereby increasing the flexibility of this approach, and enabling further insights into receptor dimerization.
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PMC2118063
We next evaluated expression of some of these genes at the protein level using immunohistochemistry to study frozen sections of human tonsil.
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PMC11545868
In another in vivo study by Li, G., et al. in male Wistar rats in which diethylnitrosamine (200 mg/kg) was used to induce liver cancer, treatment with 100 µM/kg of prunetin for 16 weeks delayed liver cancer growth, downregulated cyclin-D1 protein expression, and upregulated Bcl-2, Bax, caspase-3, and caspase-9 gene expression .
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PMC11429241
The threads for these scaffold pores were scaled accordingly to maintain the ratio between the pores and threads at as close to ∼2:1 as possible.
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PMC11783017
E and F) EDX and elemental mapping analysis of Cis/Mn@Lipo-IL11. (
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PMC11449273
The results of sequential and reciprocal co-immunoprecipitation and immunoblotting of SKOV-3- p53- (WT, 175, 273) transfectants total cell extracts using p53 and plakoglobin antibodies showed endogenous plakoglobin interaction with all three p53 forms (p53- WT, 175, 273) (Fig 2C).
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PMC9275501
In the tumor/lysosomal environment, the ester bond in the conjugate can be rapidly lysed by acid hydrolysis and/or enzymatic hydrolysis, and the dual drugs can be released synchronously at a fixed proportion.
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PMC9429973
INSURE included adult RRMM pts who had received IRd in ≥2nd LoT. Primary outcomes were PFS & time-to-next therapy (TTNT).
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PMC9429973
Although about half of all deaths after allo-HCT are due to the primary disease, non-relapse mortality (NRM) is also a major issue for long-term follow-up.
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PMC11116779
While occupational studies highlight pulmonary effects linked to PS-NP inhalation, the tested concentrations likely surpass actual environmental levels.
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PMC10820104
Detailed inspection of the 1D and 2D NMR spectra of compound 1 revealed that compound 1 is an indole diketopiperazine derivative that is structurally similar to the known co-isolated rubrumline I (2), which was previously only characterized once from Eurotium rubrum F33, a marine sediment-derived fungus collected at a depth of 2067 m under the South Atlantic Ocean .
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PMC6684588
P ≤ 0.001 vs. uninjected muscle.
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PMC10957991
for the maintenance of junctional E-cadherin.
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PMC9429973
Results: 52 HCPs (22 Hematologists/ 18 Internal Medicine/ 12 Pediatricians) from 34 hospitals had implemented the medical education program and epidemiological searching in their health area of influence for 2 consecutive years.
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PMC11680578
< 0.001 as compared to that of the RGZ alone.
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PMC11799978
Our findings show that cancer-associated fibroblasts are a versatile population that can be reprogramed toward a quiescent phenotype with reduced acidity in the tumor microenvironment.
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PMC9429973
The mean basic IgG (ref 7-16) in patients in Immunoglobulin treatment is 4,49 (range 3.3-6).The intervall for prophylactic replasment was 4.6 or 8 weeks in 20 patients.
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PMC9118379
The above results reflect a similar phenomenon to that for the comparison between SSe-gFDR and CMSe-gFDR and suggest that using different search engines and different discrimination scores for cFDR estimation yields slightly different results.
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PMC11502962
Thus, the MIF/CXCR4 signaling axis between tumor cells and macrophages was selected for further investigation.
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PMC9429973
Aims: We sought to characterize dynamic changes in serum inflammatory markers for infection vs. CRS and to develop clinical tools that discriminate for severe infections.
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PMC11634027
Deletion of the D-II region, ds, which reduces Dachs, Sple and Lft binding, led to an increase in wing size similar to that of ds flies (Fig. 6H,J).
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PMC10938336
Moreover, several cancer-related pathways were prominently identified, including colorectal and bladder cancer pathways, highlighting the potential significance of these genes in cancer biology.
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PMC8873393
Moreover, gene expression pattern of 24 h chromatin extract is similar to 3 h and non-irradiated samples (Fig. 2E), implying transcription restart during the late phase of DNA repair process.
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