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OTAR3088
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BioData-CellLine_annotated

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PMC9268620
The statistical differences between the treated and control groups were determined using Student’s t-test.
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PMC11721277
Further, cellular retention decreased over time for both cell lines and was 3.1 ± 0.2% for SKOV-3 cells and 2.4 ± 0.5% for A-431 cells (p > 0.05, unpaired t-test) after 24 h of incubation.
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PMC10507284
The R package “survival” was utilized for Kaplan–Meier (KM) analysis, and the log‐rank test was utilized to analyze the KM curves.
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PMC6889484
In vivo patient studies of elite controllers have been shown to not only attenuate Vif proteins but also increase A3G mRNA and protein levels, leading to lower HIV provirus burden, emphasizing the importance of Vif-APOBEC3 interactions in controlling viral loads.
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PMC11323699
The lack of therapeutic response to immune checkpoint inhibitors (ICI, top panel).
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PMC11119602
Conversely, no cytosolic relocalisation of TG2-S or nuclear accumulation cisplatin was observed, following the identical treatment of chemoresistant cells, where TG2-S remained predominantly membrane-associated.
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PMC11471176
This equation, exhibiting a near-perfect fit, facilitates the computation of baseline ACE2 expression levels in the EMT-6 breast cancer cell line, as well as the expression alterations following exposure to carnosine over durations ranging from 2 to 24 h. The ensuing ACE2 expression data, meticulously tabulated in Table 2, reveals nuanced observations.
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PMC9429973
Aims: Here, we present the initial results of a phase 1 dose escalation study to determine the optimal dose and preliminary efficacy of once weekly (QW) SEL in combination with RUX in pts with treatment-naïve MF.
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PMC9429973
Aims: The TRAPeze study aims to identify patient experience and preference towards specific TPO-RAs in the treatment of ITP.
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PMC11578343
The measured voltages, up to six differential voltages (V pore, V 1, V 2, etc.),
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PMC9917080
To study the effects of So, SeNPs, and SeSo, A-172 human glioblastoma cells or astrocytes of the cerebral cortex were incubated with the studied compounds (3 μg/mL), and total RNA was isolated after 24 and 48 h. PCR analysis showed that after 24 and 48 h of incubation of glioblastoma cells with So, there was a significant increase in the expression of proapoptotic genes BIM, PUMA, and Cas-3 (Figure 6A,B).
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PMC11496491
The bubble chart analysis of most significant in terms of the topsignal pathways.
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PMC11754436
Prediction and Functional enrichment analysis of DHRS4-AS1 target genes. (
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PMC11626627
We overexpressed ERβ (oe-ERβ) and knocked down TWIST1 (sh-TWIST1#1) in A498 cells.
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PMC9429973
23 of them have not been candidates due to interruption of the program due to the pandemic situation (34 remain).
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PMC8592717
Diabetic cardiomyopathy (DC) is a significant complication in type 2 diabetes mellitus (T2DM).
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PMC8956657
Models were built and refined using iterative cycles of coot and maximum likelihood phenix refine.
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PMC11538390
Conditional analysis was performed using the COJO approach (--cojo-cond command) implemented in the GCTA software (v1.93.2).
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PMC11476222
In a previous study reported by Schindler et al., 2024 , they were unable to separate GD1a and GD1b isomers, likely due to limitations in the chromatography method.
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PMC11401358
Statistical analysis of ROS levels confirmed that intracellular ROS levels in the SF and GCTS groups were significantly lower than the intracellular ROS levels in the other seven groups (Fig. 2C).
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PMC11087301
In order to establish a metastatic lesion, cancer cells must first intravasate into the bloodstream and travel through the circulatory system .
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PMC9878562
We found that LTB4 acts synergistically with CXCL12 in stimulating the migration of VAL cells.
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PMC11352311
GAPDH is not only a key enzyme in the glycolytic pathway but also plays a significant role in the development and treatment of cancer .
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PMC11665555
Metabolic reprogramming is a recognized mechanism for tumor growth and has been associated with chemoresistance.
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PMC11743975
For example, the improved light-induced dimer (iLID) and stringent starvation protein B (SspB) system has been shown to tether the ER and mitochondria together (Tkatch et al., 2017).
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PMC9429973
However, not every patient responds to alloSCT.
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PMC7334607
Right: Two waterfall plots representing the samples ranked by their responses to the two drugs, vorinostat (SAHA, top) and SP-2509 (SP, bottom).
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PMC11791478
After washing away excess labeling reagents, internalization was triggered by transferring the cells to live-cell imaging conditions (37°C, 5% CO2, 70% humidity) within the Opera Phenix Plus confocal fluorescent imager.
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PMC11629192
No tumor was detected by abdomen and pelvis computed tomography, and the patient's vital signs were unstable for pelvis MRI examination.
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PMC11687167
In the cytoplasm of hepatocytes, the antisense strand of inclisiran binds to PCSK9 mRNA, ultimately resulting in its breakdown .
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PMC11790971
SLAM composite images of randomly selected cells from each cell line are shown in Fig. 1f.
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PMC11438317
We followed our analysis with HS1 Tyr 378 and 397 (Fig. 3D).
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PMC9024365
The chimeras were then transfected and expressed in COS cells either alone or with full-length SD4 (Figures 3B–F).
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PMC6771295
p < 0.05 was considered to be statistically significant.
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PMC11297139
Scale bars: 10 μm.
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PMC10631132
Additionally, EB differentiated cells comprised a larger portion of CD11b and CD14 monocytes, suggesting an overall further downstream position compared to MB hematopoietic cells.
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PMC9429973
The overall 2-year OS rates for chemotherapy and R-chemotherapy were 51.9% and 73.1%, respectively (HR=0.42, 95%CI 0.183-0.969; p=0.042).
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PMC8633974
No off-target edits were observed with TatDE treatment in the ten loci surveyed by a Sanger sequencing-based algorithm.
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PMC10926885
New targets for the prevention and treatment of numerous malignancies, including bladder cancer, might be found as a result of our investigation.
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PMC10849234
Therefore, stem-cell derived neutrophils, while costlier and more time consuming to prepare, may still not fully recapitulate primary neutrophil granulopoiesis and granule function.
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PMC11592837
Data are presented as the mean with standard deviation, and p values are displayed with asterisks (* p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001).
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PMC11319300
We observed interactions between the MYEOV region and the CCND1 promoter-containing region in liver, lung, H1-derived mesenchymal stem cells (H1 cells) and the GM12878/GM19240 lymphoblastoid cell line (Supplementary Figure S2; Supplementary Table S5).
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PMC11088135
YAP1 was a direct target of miR-376a-3p, and it was negatively regulated by miR-376a-3p in U251 and A172 cells.
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PMC9429973
On further enquiries, the eldest was found to have mild to moderate menorrhagia, that didn’t require any medical advice.
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PMC11544122
5A variant receptor (d).
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PMC8409415
Three cases with advanced renal cell cancer (clear cell carcinoma) were immune‐stained as positive controls, and three healthy ovary specimens were used as negative controls (formalin‐fixed, paraffin‐embedded sections were obtained from surgical treatment cases at Osaka University Hospital).
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PMC8193046
However, small-molecules would represent a potential tool to monitor, influence, and study these transporters for (i) a general understanding of their mechanism of action, and more importantly, for (ii) their exploration as potential pharmacological targets to develop innovative diagnostics and therapeutics.
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PMC10243817
At the 14th, 17th, and 21st day of differentiation, the HNECs maintained in ALI culture were pretreated with EGF (100 μg/mL; Sigma-Aldrich) for 15 minutes and then were transfected with pcMEX3B, pcGUSB, or the corresponding negative control pcDNA using Lipofectamine 3000 (InvitroGen) for 24 hours.
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PMC11791264
Figure 3SETD7 methylates LC3B at K51, leading to LC3B ubiquitination and degradation.
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PMC11040965
Nonparametric statistical tests were used because much of the data were not distributed normally.
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PMC11666785
The corresponding region-of-interest is marked (red and yellow boxes).
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PMC10926885
At the transcriptional or other regulatory level, some genes have a reciprocal regulatory association, whereby their expression levels demonstrate a notable connection, either positive or negative.
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PMC11395280
We were able to determine that at 100 nM CCL198-83, the antagonist can selectively inhibit migration to CCL19 but not CCL21.
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PMC11760643
A, B) Percent cytotoxicity was assessed using a spectrophotometric LDH release assay.
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PMC11774747
This was first reported in the context of allo-SCT, with low GvHD incidence, whereas VST presented cross-reactivity with recipient HLA molecules in vitro (71).
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PMC11726848
Statistical analysis is performed using the ANOVA Dunnett test to compare a group of unirradiated cells and those irradiated with different doses.
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PMC8494202
To date, many effective biomarkers have been identified through database analysis methods for the diagnosis and targeted treatment of glioma, including CD276, HLA-F, and CMTM6 [8–10].
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PMC11395280
The cells were washed 3 × in PBS/2% BSA.
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PMC11297139
d The normalized Hi-C contact frequencies around the TFAP2B gene promoter are illustrated as a virtual 4C plot.
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PMC10522430
The extraction procedure, as detailed by Susilo et al. , was pursued.
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PMC11291490
The black arrows indicate the E proteins.
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PMC11502443
The E354Q variant is associated increased risk of T2D and lower body mass index.
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PMC10818573
In this study, a single reaction system (50 μL) could detect 1 × 10 copies of EBV, but in a similar study of RPA combined with an LFA for virus detection, the detection sensitivity was as low as 200 copies .
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PMC11750161
The cells were passaged at a 5–6×10 cells/mL in 125 mL CHO expression medium in a disposable spinner flask.
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PMC5673955
The standard curves of reaction effectiveness were performed using four serially diluted samples (1:40, 1:80, 1:160 and 1:320) of each protein or 18S cDNAs.
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PMC11052306
Among the other metals that have been examined for potential applications as anticancer agents is copper.
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PMC5839394
Equal amounts of total proteins (5 µg) were separated by electrophoresis, on a 7.5% sodium dodecyl sulfate (SDS)–polyacrylamide gel containing 0.1% gelatin, under non-reducing conditions.
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PMC10391797
Structure of CD123 and CLL-1 CARs; both CARs consist of a CD28/CD3ζ or 4–1-BB/CD3ζ intracellular signaling domain, truncated epidermal growth factor receptor (tEGFR), and a single-chain variable fragment (scFv) of a specific antibody of CD123 and CLL-1. (
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PMC10329237
However, it may be caused by repeated micro-injuries of the alveolar epithelium and overproduction of reactive oxygen species (ROS) (3).
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PMC2614415
The TMA staining data, including detailed patient information is summarized in Table 3.
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PMC10713411
The results showed that 87.8% (36 in 41) of these genes had a significant correlation with the prognosis of KIRC patients; specifically, high expression of 11 genes (AP1M2, ATP6V0A4, ATP6V0D2, CA9, EYA4, HMOX1, MAP6, MYH14, NTRK2, SFRP1 and UMOD) contributed to favorable prognosis of KIRC patients, while the high expression of the other 25 genes (ACKR3, ACSF2, ATP6V1B1, ATP6V1C2, BMPR1B, CD27, CD300A, CD3E, CD70, CDKN2A, CP, CTSW, DCN, LAPTM5, MMP9, MT1G, MUC1, NOL3, PROM2, PTGDS, RAC2, TREM2, TRIB3, TYROBP and UCHL1) led to poor outcomes in patients (Supplementary Figure 2A).
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PMC4112127
Quantitation of BMP3 expression by real-time PCR 48 hours after transfection showed a five-log increase in BMP3 expression in Mz-ChA-1 cells transfected with a BMP3 expressing plasmid construct, in comparison to vector transfected cells (Figure 5A).
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PMC9429973
A 10-15% reduction in proliferation and viability was seen at day 9.
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PMC11194678
Lower: Statistic graph of mRFP-GFP-LC3 tandem assay showing an increased autophagosome/autolysosome ratio in STHdh cells compared with STHdh cells, indicating low autophagic flux.
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PMC11438317
C, Wild type and 494 Jurkat cell lines were plated on coverslips covered with CD3 antibody for the indicated periods of time.
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PMC11754436
To confirm DHRS4-AS1 expression in OS, the difference in the expression levels of DHRS4-AS1 between OS cell lines and the hFOB1.19 human osteoblast cell line was first detected.
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PMC11585254
Data were normalized to pcDNA condition and represent the mean ± S.D. Data were analyzed by a student’s t test.
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PMC6835428
Byeon et al. described the use of PLGA conjugated with HA (PLGA–HA) to target OC cells overexpressing CD44 (see Section 4.1) (Table 6).
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PMC9428827
NKTR-214 shows a potent antitumor effect both alone and in combination with a PD-1 mAb.
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PMC11763111
B Bioluminescence imaging (BLI) results of tumor burden.
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PMC9444294
These results are congruent with previous ChIP experiments in cell lines engineered to express epitope-tagged SS18-SSX.13,17 These data add on to a previous report that showed enrichment in the promoter region of TLE1 and BCL2 using ChIP-seq.14 ChIP enrichment at SS18-SSX target gene loci.
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PMC11629461
DUOX2‐CHO‐K1 cells.
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PMC10588957
One of the best-documented cases is cancer, in which pathogenic cellular remodelling is intricately mediated by autophagy (13, 14).
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PMC11442172
In 2017 and 2019, two physiological media that more accurately represent the metabolic profile of human plasma were formulated, termed human plasma-like medium (HPLM) (26) and Plasmax (27).
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PMC10713411
RCC, particularly KIRC, is the most prevalent type of kidney cancer, causing significant global health concerns and mortality.
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PMC11739504
Immunocytochemistry data of Smo protein (green) at primary cilia (red) in Kat2b KO MEF cells with serum starvation for 24 h and 400 nM of SAG.
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PMC10669966
However, 90% of DDLPS tumors arise de novo.
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PMC11665555
While a partial restoration of gemcitabine sensitivity was observed when the 5637GR cells were treated with S-βHB (P < 0.001), the extent of sensitization did not approach that of the parental line.
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PMC9429973
Results: 47 pts were analyzed: median age was 55 years (range, 22-70); histologies included diffuse-large B-cell lymphomas (n=33) and primary mediastinal B-cell lymphomas (n=14); pts received treatment with axi-cel (n=31) or tisa-cel (n=16).
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PMC11476004
The study was carried out in strict compliance with Directive 63/2010/EU and the Journal of Laws of the Republic of Poland of 2015 on the protection of animals used for scientific or educational purposes.
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PMC10291556
The blank (no ATP) was subtracted from the raw data.
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PMC10968586
In a model of cyclophosphamide-induced immunosuppression in broilers, a solution containing 200 mg/L HT promoted the duodenal expression of anti-inflammatory cytokines IL-4 and IL-10 .
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PMC8750422
After a week, 1.0 × 10 lung cancer cells resuspended in 100 μL phosphate-buffered saline (PBS) were intravenously administered via tail vein injection.
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PMC11730305
Cobalt is an essential trace element for normal metabolism of animal cells.
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PMC11453018
By employing this dual approach, we echo successful methodologies used in other cancer contexts and position it as a forward-looking avenue for ES treatment.
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PMC11748618
Here we perform a heuristic functionally informed fine-mapping approach in the African ancestry sample of the International Collaboration for the Genomics of HIV (ICGH) cohort to identify which variants likely drive CHD1L gene expression changes and the overall impact of genetic variation on CHD1L expression.
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PMC9429973
However, due to the high cost of sequencing, developing a two-stage algorithm for detect mutations in JAK2 exon 12 using inexpensive screening is of immediate practically necessity.
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PMC11422497
Further research is needed to elucidate the specific roles and underlying mechanisms of circRNAs in GISTs tumorigenesis and progression.
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PMC10656496
Bulk sequencing has not yet identified a clear therapeutic target in osteosarcoma.
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PMC11611077
After drug selection, cells were plated at a density of 1 cell/well in 96-well plates using the limiting dilution method.
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