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OTAR3088
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BioData-CellLine_annotated

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PMC10094712
Interestingly, a decrease in SELENOF activity in various cancer cells led to plasma membrane blebbing , a process in which actin plays an important role: actin microfilaments are reorganized into membrane-bound peripheral annular bundles, while the cell acquires a rounded shape and further contraction of the rings leads to membrane blebbing and ultimately to cell apoptosis.
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PMC11640555
To measure intracellular hydrogen peroxide (H2O2) levels in GBM cells , the intracellular hydrogen peroxide assay (#MAK164, Sigma-Aldrich, St. Louis, MO, USA) was performed by following manufacturer’s instructions.
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PMC11052306
The functionalized dendrimers (generations zero of series 11-G0-[Cu] (R = Me) and 12-G0-[Cu] (R = OMe)) were also tested against Staphylococcus aureus biofilms, as were the unfunctionalized dendrimers (10-Gn-[Cu] (R = H)).
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PMC11767793
There could be residual PEI left over from the particle synthesis procedure, or it can be released from the Au-PEI@NIST shell.
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PMC11765243
Class IA PI3K catalytic subunits in mammals are p110α, p110β, or p110δ and can form dimers with distinct regulatory subunits (p85α, p50α, p55α, p85β, and p55γ).
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PMC5673060
The observation that protein-protein interaction networks involving the histone deacetylases (HDACs) are enriched in A204 parental cells in both the PazR/A204 and DasR/A204 experiments (Figs. 3C and 5C) is consistent with recent preclinical reports that HDAC inhibitors have therapeutic utility in reducing the proliferation of rhabdoid tumour cells including the A204 line , , .
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PMC10040136
The cell density and medium composition are consistent with those of the contact co-culture model.
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PMC11777207
As in our human moDC migration assays with αPD-L1 atezolizumab (Fig. 1), we found significantly fewer numbers of transferred DCs in the dLN (Fig. 6, B and C).
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PMC11626627
The protein encoded by the TWIST1 gene promotes tumor cell invasion, metastasis, and recurrence.
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PMC9895440
Curves are shown until the first mouse per group reaches the humane endpoint.
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PMC9429973
Median OS was 75 mo.
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PMC11656657
For in vitro experiments, sarcoma cell lines [RD, 143B, 143B CXCL8 knockout (143B CXCL8), 143B G-CSF knockout (143B G-CSF), HOS, SAOS-2, U-2OS and MG-63] were plated 1 × 10 cells/ml in 24 well-plate.
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PMC11489351
After processing the RNA-Seq data, a table was uploaded to MetaCore containing the mapped gene ID, the log2 Fold change, and the FDR for only the statistically significantly different genes from each comparison (EIPA versus control and NH4Cl versus control).
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PMC9479186
Small hairpin RNA (shRNA) (10 μM) targeting to human NDUFC1 was synthesized based on selected target sequences by the Generay Biotech (Shanghai, China).
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PMC11085211
Considering the doubling time of GIST-882 and GIST-T1, experimentally calculated as approximately 48–72 h, the effects observed following AUN treatment could be due to both the inhibition of cell proliferation and cell death.
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PMC9848491
The purpose of this study was to establish relies on the signature of ER stress-related lncRNA forecast to predict the prognosis of patients with UCEC.
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PMC11753435
In parallel to the PepPrCLIP approach, RFDiffusion was used to design peptide binders for both cases.
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PMC11306331
Lentiviral transduction can drive a wide range of protein expression levels depending on integration site, and we sorted cells to cover a ~ 10-fold range of expression of both components of the system (Fig. S4A).
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PMC5810978
10 RNA copies/mL) on 1-month and 2-month cultured Caco-2 cells using the PEDV medium.
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PMC5535901
Twenty-four hours later, treatment began.
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PMC9847912
In such cases, the 293T/17 supernatants were diluted in complete DMEM at a constant, fixed ratio across the entire dose-response series (including samples from the no-drug control wells); this was done immediately prior to the addition of the 293T/17 supernatants to the MAGIC-5A assay plates.
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PMC11201989
Exogenously expressed GFP-tagged PD-L1 (GFP-PD-L1) also accumulated at the Golgi region when co-stained with γ-tubulin in NIH3T3 and IMCD3 cells (Supplemental Figure S1D) and overlapped with GIANTIN in RCTE cells (Figure 1E) and RPE cells (Supplemental Figure S1E).
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PMC11453018
Over the last fifty years, improvements in diagnosis, surgery, chemotherapy, and radiation have increased survival rates to nearly 70% for localized ES, yet the prognosis for patients with metastatic or recurrent forms remains challenging, with a five-year survival rate still below 25% .
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PMC11001582
Graph, mean ± s.e.m.,
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PMC11411004
Therefore, we speculate that I-4 inhibition of HDAC5 may enhance the acetylation level of histones, while H3Kac acts as an enhancer and further binds to the promoter, activating its transcription, which may be the reason for promoting the expression of recombinant proteins.
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PMC11173119
IPSC-derived macrophages from a healthy donor were found to have a classic cloaked, spreading morphology (Figure 2C), whereas macrophages with the pathogenic p.M694V mutation in the MEFV gene had an elongated morphology with many rounded cells (Figure 2D, middle photo, white arrows).
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PMC11078693
Timing: 1 day 8.Mounting cover glass into a Chamlide magnetic chamber.a.
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PMC11659921
D, E) PCR and western‐blot were used to detect the inhibition efficiency of small interfering RNA in HEY cell line. (
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PMC11791264
J, SETD7 OE promoted the migration of SKOV3 cells determined by the Transwell assay.
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PMC11725127
From this curve, the inhibition constant (Ki) and the rate of inactivation (Kinact) of GA to USP2 were determined to be 2.597 μmol/L and 0.03 min, respectively.
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PMC9429973
Are there less errors with electronic prescribing?
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PMC11055443
The mean NO production in Caco-2 cells treated with secretome and V. cholerae in 12h and 48h supernatants was 5.42 ± 2.18 and 9.51 ± 1.22 μM, which decreased by 34.3% (P= 0.02) and 42.81% (P= 0.0007), respectively compared to Caco-2 cells treated with V. cholerae (Fig. 6).
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PMC11730311
When one of these amino acids was already present in the backbone, a glycine (G) was induced as alternative.
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PMC11700165
Nuclear and cytoplasmic fractions of Jurkat cells were transfected with the corresponding plasmids named in 3A.
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PMC11666785
B, C Corresponding statistics for mean localization precision and the number of molecules with blinking time are also shown.
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PMC11224020
b, Pie charts showing proportions of differentially expressed genes in cells under confined conditions compared to nonconfined cells (false discovery rate < 0.05 and log2 (fold change) of <–1.0 or >1.0).
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PMC11257203
All animal care and experiments were approved by the Ethics Committee of Guilan University of Medical Sciences (Ethical code: IR.GUMS.REC.1399.493).
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PMC10890055
In our opinion, the physiological temperature of 37 °C is ideal for the testing of biomaterials using the hFOB 1.19 cell line.
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PMC8557138
Failure to re-establish a functional vasculature due to inadequate angiogenesis results in ischemia, causing permanent damage to the affected tissue, compromising its functionality (Chertok et al. 2019).
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PMC11714165
The fluorescence resonance energy transfer (FRET) experiments further validated the co‐assembly of both peptides in the nanoparticles (Figure 4D).
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PMC7642379
Gene enrichment analysis of this set of 38 differentially expressed genes between adherent and suspension cells, performed using Enrichr, predicted the cholesterol biosynthetic process pathway as the cellular pathway most affected by this expression variation (Fig. 5b).
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PMC10335954
A xenograft model showed that subcutaneous neoplasms that developed from MGC-803 cells transfected with LVpGCSIL-shTRIP13 were smaller than those from psc3741-shCtrl-transfected MGC-803 cells (Fig. 2E).
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PMC11489175
The identified and validated hit fragments target OTUD7B and UCHL3.
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PMC11700247
G-H) CD45/CD3 and CD45/CD3/CD8 T-cell infiltration in irradiated and abscopal tumors 34 days after tumor implantation.
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PMC11721096
The final solutions eluted with 30% methanol were designated as S5-A and S5-C, respectively.
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PMC11363012
Compounds colored green are iridoid monoterpenes, which are also precursors for monoterpene indole alkaloids, shown in blue.
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PMC11116779
The world distribution of MPs in the atmosphere seems to be quite ubiquitous.
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PMC11496728
CHO-S cells were cultured in a constant-temperature cell culture incubator set at 37 °C with 5% CO2.
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PMC10589262
The major challenge of GIST treatment is that there are insufficient regimens for patients showing poor response or developing resistance to imatinib .
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PMC11400680
Our proposed method typically achieves final segmentation results within approximately 2 minutes.
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PMC9516401
cepa (600, 300, and 150 µg/ml), and HAEC (40, 20, and 10 µg/ml) according to the manufacturer’s instructions (Yekta Tajhiz, Tehran, Iran).
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PMC9954564
MDR reduces the dimensionality of multilocus information by testing all the possible combinations of multilocus genotypes and reports the ones exhibiting the best classification for disease risk .
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PMC10452486
The synthesis of intact HLAs or B2m mRNAs or of L31 proteins did not change in differentiated NB cells, suggesting that the surface expression of B2m-free HCs is regulated post-translationally.
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PMC11696659
A, difference between the 99th percentile of the telomere lengths of a sample and the 1st percentile of the telomere lengths of that sample (p < 0.0001).
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PMC11638288
HSPGs, heparan sulfate proteoglycans; HA, hemagglutinin; ecto-CRT, ecto-calreticulin Expression and function of NKp46 ligand HA hemagglutinins, HMPV human metapneumovirus, HCMV human metapneumovirus, HBV hepatitis B virus, HSPGs heparan sulfate proteoglycans, ecto-CRT ecto-calreticulin, CFP the complement factor P NKp46 is a natural cytotoxicity receptor believed to be the principal cytolytic receptor of NK cells, selectively expressed in all resting and activated NK cells, non-NK innate lymphoid cells (including the LinNKp46NK1.1CD49bCD49a ILC1 subset of group 1 ILCs and the LinCD127RORγt ILC3 subset of group 3 ILCs), and a small subset of T cell populations (NKT cells) .
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PMC11026382
TYMS R127A, a less severe loss of function mutation, showed a similar albeit more modest trend—this mutation was able to partly rescue growth for some (though not all) DHFR mutations.
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PMC7136814
In both cell lines, the percentage of MYOD1+ NOG+ cells increases in a dose-dependent manner with either treatment (Figures 1(a) and 1(b)).
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PMC9429973
NGS-MRD was performed on genomic DNA using targeted NGS-error-controlled sequencing method (Ion-Torrent S5XL) with a sensitivity between 0.1 and 0.001%.
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PMC10713411
PDCD1 and CD274 differentially modulate the prognosis in lung adenocarcinoma or squamous cell carcinoma , and rational combinations of first series (CTLA-4, PD-1 and PD-L1) and second series (TIGIT, TIM-3 and LAG-3) of inhibitory receptors might be an optimal immunotherapy approach because of the coexpression or/and compensatory mechanisms in various cancers .
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PMC11365983
Subsequent studies revealed essential roles in arterial specification, angio- and somitogenesis, stem cell quiescence and hematopoietic progenitor formation.
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PMC11754784
Then cells were washed with washing buffer three times and imaged using confocal microscope.
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PMC10748106
Genipin exerted a similar effect in the CaSki and CaLo cell lines and exhibited less potency in the INBL cell line.
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PMC9275501
Sahu et al. (2016) prepared nanosuspension of poorly water-soluble CUR and DTX by precipitation homogenization technology, and modified it with polyethylene glycol to increase its solubility and bioavailability, thereby improving the efficacy.
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PMC10165258
In addition to this, the good integration of such microfluidic devices with microscopy techniques provides a method to obtain a large amount of data from a limited number of cells.
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PMC9046263
In cancer cells, which often have epigenetic dysregulation, HERVs have been implicated as potential oncogenic drivers.
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PMC9429973
Methods: All pt-derived bone marrow (BM) and peripheral blood samples were obtained in accordance with IRB (OHSU#004422) approval.
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PMC7582629
Thus, PCA/LDA is becoming a widely used method for the spectral analysis of multi-components samples.
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PMC11395280
Transmigration of CCRF-CEM through Cerebral Microvascular Endothelial Cell Monolayers.
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PMC11653168
Mice were subsequently randomized into the following five groups (n=6 mice/group): Vehicle control group and four treatment groups, each receiving three different doses of Stattic (7.5, 15 and 30 mg/kg) or DEX (1 mg/kg; Taiwan Biotech Co., Ltd.).
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PMC9429973
After intervention with different concentrations (0, 10.0, 20.0, and 40.0 μM, respectively) of Drp-1 inhibitor Mdivi-1, the Drp1 mRNA level was significantly reduced.
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PMC8382973
Antiviral activity of the 2P23 gel under different pH and H2O2 conditions.
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PMC11705630
Furthermore, we found that 24 h after Dox exposure, approximately 60% of control cells are found arrested in G2/M phase while little more than 20% of GLDC knock-downed cells are found arrested in G2/M phase (Fig. S3A).
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PMC11367146
The species option was set as “Homo sapiens”, and a high threshold score of 0.7 was selected.
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PMC11126803
A, at the mRNA level, ZEB1 is specifically related to ERβ compared to the other six VM marker genes, which suggests that ERβ is likely to affect the VM formation in RCC through regulating ZEB1.
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PMC7823217
Fluorescence images of bioprinted hESC-derived hepatocytes: a 3D stack of hepatocyte-like cells printed in hydrogel, measured one hour after printing displaying live cells in green and dead cells in red (c) 2D cells collected from the alginate at day-23 indicating albumin expression in green and cell nuclei (DAPI) in blue.
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PMC11617590
Protein concentration was quantified using a Bio‐Rad protein assay kit (Bio‐Rad) standardized to bovine serum albumin (BSA).
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PMC8041314
The dataset for ongoing analysis, including compound names and SMILES codes, can be found in Supplementary Table 2.
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PMC8633974
Thus, CRISPR can simultaneously cleave essential rev and env genes that are transcribed from the same portion of the genome but in alternate open reading frames .
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PMC10667689
Based on these data, we aimed to investigate the role of TIM-3 on metabolic reprogramming in AML cells by using two AML cell lines, HL-60 and THP-1, representing M3 and M5 AML subtypes, respectively .
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PMC5261804
We separated patients into those with or without each of the PPIs in our superpathway network based on the presence or absence of nonsense mutations, frameshift mutations, or homozygous deletions for each of the partner proteins.
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PMC11588085
Since XIST is involved in X chromosome inactivation, we first examined whether XIST loss led to the reactivation of X-linked genes.
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PMC10362265
Fluctuations of the human tetramer were shown in orange and green lines representing each subunit in the 2:2 complex.
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PMC10849234
PLB-985 cells and HL-60 cells are old and commonly used laboratory cell lines.
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PMC6892818
4Induction of pro-inflammatory cytokine secretion in human RCC lines vs. normal HRPT cells is dependent on the mode of CD40 ligation.a–c RCC cell lines ACHN, 786-O and A-704, the positive control EJ and normal HRPT cells were treated with mCD40L.
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PMC11658074
i The mRNA expression of Col1A1, MMP9, and CDKN1A in the two groups.
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PMC9429973
Summary/Conclusion: The Molecular Diagnostics–Arizona Laboratory (MDAZL) has performed a full clinical validation of the performance characteristics of the Lymph3Cx assay and is the first molecular diagnostics laboratory to offer the Lymph3Cx assay as a clinical molecular diagnostic test for distinguishing PMBL from DLBCL and molecular cell-of-origin subtyping of DLBCL to patients both inside and outside of the Mayo Clinic.
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PMC9429973
24 (61.5%) of patients were male, the median age is 58 years (range 36 to 76).
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PMC11314247
no. P8340; Sigma-Aldrich, St. Louis, MO, USA; Merck KgaA, Darmstadt, Germany).
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PMC10958426
In this way, we completed genomic DNA amplification from single cells.
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PMC10877303
The higher SASA values of the Nafamostat-3CL complex signify the expansion of the protein surface area.
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PMC9429973
S. Delimpasi, H. Quach, M. Cavo, P. J. Ho, C. H.-S. Lee, A. Santoro, R. Schots, P. Vlummens, D. H. Yoon, S.-S. Yoon, C. D. Santos, D. Samineni, J. Huang, K. Wehrman, U. Patil, S. Sheikh, M. A. Dimopoulos Department of Hematology and Lymphoma, Evangelismos Hospital, Athens, Greece; Faculty of Medicine, University of Melbourne, Department of Haematology, St. Vincent’s Hospital, Melbourne, VIC, Australia; IRCCS Azienda Ospedaliero‐Universitaria di Bologna, Istituto di Ematologia “Seràgnoli”, Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale, Università di Bologna, Bologna, Italy; Institute of Haematology, Royal Prince Alfred Hospital & University of Sydney, Camperdown, NSW; The Queen Elizabeth Hospital and Royal Adelaide Hospital, SA, Australia; Cancer Center in Humanitas Research Hospital, Milan, Italy; University Hospital Brussels, Brussels; Department of Clinical Hematology, Ghent University Hospital, Ghent, Belgium; Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine; Seoul National University College of Medicine, Seoul, South Korea; Genentech, Inc., South San Francisco, CA, United States of America; F. Hoffmann-La Roche Ltd, Basel, Switzerland; Department of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece Background: Multiple myeloma (MM) remains an incurable disease.
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PMC11200978
When the combination protocol included a repeat freeze, in samples exposed to a repeat −15 °C freeze (Figure 3B), near-complete cell death was observed.
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PMC11615828
Dimerization of three different pairs, FRB/FKBP, GAIs/mGID1, and Cry2/CIBN, can be triggered by rapamycin (Rapa), GA3‐AM, and blue light, respectively.
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PMC9874064
The above results may be attributed to C527 and cisplatin released from the NPs, thereby sensitizing DNA damage, and enhancing the anti-tumor efficacy in vivo.
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PMC6160470
Further, co-treating MDR cells with DAC-amide crown ethers and representative chemotherapeutics results in a pronounced reversal of the MDR phenotype.
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PMC11354225
The ability of EGCG to generate reactive oxygen species (ROS) and influence cell signaling pathways related to cell growth and apoptosis makes it a promising complement to PDT.
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PMC10705095
This specific expression pattern makes HBQ1 an attractive option for reducing ROS levels in lung adenocarcinoma without affecting erythrocyte function.
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PMC11548041
Several aptamers have been tested in early phase clinical trials and have been shown to be well-tolerated and also to synergize with combination treatment .
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PMC2777936
p < 0.05, **p < 0.005, ***p < 0.0005).
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PMC9429973
The overall CR/CRi rate in the 23 patients (42%) who had prior alloSCT vs the 32 patients (58%) who did not was 70% (47-87) vs 72% (53-86), respectively.
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