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PMC11482552
Results: The cellularity values obtained were comparable across the three different methods for all dilutions of the cell line tested.
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PMC11525293
Starting from these evidences, we hypothesized that the beneficial effects observed in COVID-19 patients treated with Thal could stem from ΔNp63α degradation, with p63 eventually playing a role on the regulation of ACE2.
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PMC9429973
The hormone erythroferrone (hERFE) is produced by erythroblasts in response to erythropoietin (EPO), and acts by suppressing hepcidin, thereby increasing iron absorption and mobilisation for erythropoiesis demand.
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PMC11469524
We show that this model is transferable to perturbation data of another BL cell line BL-41.
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PMC9014716
IBM Corporation, Armonk, NY, USA) or GraphPad Prism 8.0 software (GraphPad Software, Inc., San Diego, CA, USA).
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PMC9000591
After fractionation by different solvents, the yields of hexane (SH), ethyl acetate (SE), butanol (SB), and water (SW) extracts were 5.4 (0.42%), 4.84 (0.38%), 13.6 (1.06%), and 114.11 g (8.89%), respectively.
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PMC11787381
The overall delivery of the drugs (bambuterol + terbutaline) into the brain is quantitatively the same according to the two routes of administration.
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PMC9429973
Summary/Conclusion: Donor-derived CD7-CART followed by allo-HSCT has achieved similar survival (OS, DFS) and lower relapse rate and TRM compared with chemotherapy followed by allo-HSCT in r/r T-ALL.
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PMC11658074
b PKH26 and immunofluorescence staining of CD151 in cells after incubation with PKH26-labelled ADSC-EVs or AT-EVs for 30 min.
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PMC11185260
With the combination therapy of scL-SMARCB1 and cisplatin, the expression of both cCasp3 and cPARP was substantially increased compared to cisplatin monotherapy.
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PMC11756907
Data were analyzed with GraphPad Prism Software version 8.0.1 using bidirectional ANOVA with Tukey’s multiple comparison tests; **p < 0.01, ****p < 0.0001 versus control.
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PMC11116779
Figures 5A,B show an increase in the percentage of apoptotic cells in all the samples exposed to the PS-NPs, with the 100 and 500 mg/mL having about a threefold increase when compared to the untreated cells.
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PMC11291697
Asynchronous diffuse bilateral polyspike-waves discharges, prevalently over the posterior regions, were recorded.
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PMC11759543
5637 and BFTC 905 cells were pretreated with 40 μM Z-LEHD-FMK for 1 h, then cultured with seleted doses of doxorubicin and vorinostat for 24 h. Protein expression were analyzed by Western blot. (
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PMC9000591
Particularly, oxidative stress can exacerbate inflammation and vice versa, while inflammation is considered to be the key physiological process in the development of serious chronic diseases, including cancer .
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PMC9429973
DIC is an acquired condition characterized by systemic activation of coagulation, intravascular fibrin degeneration, consumption of platelets and coagulation factors along with fibrinolytic imbalance.
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PMC11224020
i, Left, representative images of Arpin/Arpin DCs.
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PMC11678368
Cisplatin was used as a reference compound.
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PMC9599726
The total protein concentration was measured based on the Bradford assay using the Bio-Rad Protein Assay Kit II (Bio-Rad, Hercules, CA, USA, Cat# 5000002).
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PMC8633974
To further confirm the findings, U1 and JLat cells were harvested 72 hours post stimulation, and RNA was extracted using TRIzol method.
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PMC9429973
Secondary endpoints include efficacy, tolerability, and pharmacokinetics (PK).
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PMC11588085
The downregulation of XIST was associated with a higher stemness index and an unfavorable prognosis, suggesting that XIST plays a role in regulating ovarian cancer SCs.
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PMC8633974
b-d) RT activity was recorded from culture supernatant fluids.
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PMC9412887
Studies have shown that the composition, size, morphology and surface charge of nanomedicines can all affect their biological effect and distribution in organisms.
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PMC10565698
Stable cell lines were obtained after treatment with puromycin.
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PMC7519871
The inhibitors of the the Akt pathway can improve cisplatin-induced chemotherapy.40 WDL is also reported as a potent inhibitor of the Akt signaling pathway41.
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PMC11718809
Our results show consistency with circRNA data identified from other species, showing high reliability.
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PMC10887351
The pregnant myometrium and early embryo development shared similarities between the environments surrounding the tumor and embryo.
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PMC10317042
Indeed, we demonstrated that SOX10 knockdown attenuated CCS proliferation.
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PMC11539788
These DEGs related to RNF19A were subsequently subjected to functional enrichment analyses.
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PMC9780037
Unlike in cancer, cyt c is elevated in the serum of myocardial infarction patients , for which some cyt c biosensors have also been developed .
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PMC11298021
The present study utilized flow cytometry to evaluate cell cycle indices and establish the precise mechanism by which rapamycin and miRNAs inhibit cell viability.
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PMC11747949
Analysis of paraffin‐embedded osteosarcoma specimens showed that all types of osteosarcoma had CCR2 gene expression (von Luettichau et al. 2008).
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PMC11679892
Approximately 90% of neuroblastoma patients exhibit chromosomal changes, including MYCN amplification, ALK mutations, and 1p or 11q deletions, which are linked to disease progression and poor outcomes .
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PMC9429973
The most common combination of high-risk features was +1q21 plus t(4;14) (40%).
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PMC11206251
JAK2 and STAT3 were purchased from HUABIO (Hangzhou, China).
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PMC9429973
Aims: To compare semen analysis parameters before and after TKI therapy in CP-CML patients treated in the haematology department of Imperial College Healthcare NHS Trust (ICHNT).
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PMC11683240
Harvest was done at 8 days post infection.
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PMC10174970
Cancer cell lines are important research models for studying tumor biology in vivo.
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PMC9429973
Methods: Patients underwent thorough evaluation for CVD every 6 months.
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PMC9436459
Artonin I (101) could inhibit multidrug resistance in Staphylococcus aureus and potentiate the action of inactive antibiotics in vitro .
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PMC11472639
Monocyte populations were immunophenotyped via direct immunofluorescent antibody staining procedure of whole blood using the following antibodies: anti-CD3-APC-H7 ((SK7), anti-CD14-PE-Cy5.5 (Tuk4), anti-CD16-BV510 (3G8), anti-CD32-PE (FLI8.26), anti-CD33-BV421 (P67.6), and anti-HLA-DR-AF700 (G46-6) (BD Biosciences, Wokingham, UK).
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PMC11549612
Although BOLA family members, such as BOL2 and BOLA3, have been implicated as assembly factors for mitochondrial Fe-S cluster proteins with roles in cancer cell biology, the specific functions of BOLA1, BOLA2, and BOLA3 in cancer remain unclear.
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PMC11770199
For this purpose, HCT8 and A375 cells transfected with PCDH-GFP-p14 plasmid were used as effector cells and cocultured with the corresponding target cells transfected with empty vector (PCDH-mCherry).
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PMC11786767
Lipids are key biomolecules that form the structures of biomembranes and serve as signaling molecules to regulate cellular responses.
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PMC11342785
E, schematic depicting strategy for systematically varying the microtubule-interaction component (TPPP variant) of an inducible synMAP TPPP-IDR circuit.
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PMC11755624
In this paper, we did not focus on psoriatic arthritis, an important subtype of psoriasis involving the joints.
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PMC9219615
Apoptosis was validated as the primary mode of Tpz-1-induced cell death in HL-60 cells by detecting Annexin V-FITC bound to exposed phosphatidylserine at the cell surface (Figure 3a).
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PMC10759659
Three datasets were explored in this study.
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PMC9503541
A prior study by Raheem et al. highlighted the application of combined metabolomics and bioactivity-guided approaches for the successful isolation of a norlanostane-type saponin glycoside with significant antitrypanosomal activity from British bluebells (Hyacinthoides non-scripta) plants .
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PMC9429973
Of note, no peptides corresponding to the mutant CALR were detected using label-free MS methods.
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PMC11594641
The SkMel28 human melanoma cell line was purchased from the American Type Culture Collection (ATCC) (Manassas, VA, USA).
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PMC10197932
Lymphocytes were grown at 1 x 106 cells/ml in 12-well plate with RPMI-1640 supplemented with 10% FSC and treated with (2T) 20 s, then seeded onto a 24-well plate and followed by incubation of 24 hours as described above.
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PMC9429973
Of 53 FLT3-ITD positive, evaluable subjects, CR/CRh rate was 17.0% (9/53), and CRc rate was 45.3% (24/53).
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PMC11367939
B COS7 cells co-expressing ATG9A-EGFP, synaptophysin (untagged), and mCherry-synapsin were incubated with 10 μg/ml cholera toxin-conjugated HRP (CHX-HRP) for 36 h and then fixed for correlative light and electron microscopy (CLEM).
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PMC11314247
The human breast cancer MCF-7, MDA-MB-231, and SKBR3 cell lines were obtained from American Type Cell Culture (ATCC).
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PMC11507371
Statistical analyses were conducted utilising GraphPad Prism 8 software (GraphPad Software, San Diego, CA, USA).
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PMC9429973
She was treated with fondaparinux at 1.5 mg/ day due to sepsis-associated acute kidney injury requiring hemodialysis.
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PMC11078693
Store for up to 2 days at 4°C until imaging.
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PMC9429973
Doxycycline 100 mg daily was substituted for penicillin prophylaxis in patients with penicillin allergy; since 2013, doxycycline has become the standard for prophylaxis in AL amyloidosis at our institution.
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PMC10938377
In order to avoid potential interactions with the Au(i) cation, the Met residue in the wild type LANA peptide was replaced by ornithine (Orn; Fig. 1 and below).
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PMC11574271
This observation was further confirmed by Western blot analysis using the 2 cell pairs as described above.
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PMC8777939
They were cultured in high-glucose Dulbecco’s modified Eagle medium (DMEM) (Welgene, South Korea) supplemented with 10% fetal bovine serum (FBS) (Gibco, Thermo Fisher Scientific, Hillsboro, OR, USA) and 100 µg/mL penicillin–streptomycin (Welgene, South Korea) at 37 °C and 5% CO2 in a humidified incubator.
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PMC11599565
Panel D: Primary ovarian carcinoma 3D cell cultures with neuronal morphology and phenotype.
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PMC11789597
MM cells (5 × 10 cells mL) stably expressing shNC or shCAV1 were treated with or without bortezomib at the indicated concentration for 48 h and the viability was measured with the Cell Titer glo Luminescent Viability assay (Promega, Madison, WI, USA).
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PMC11790599
Fluorescent dyes are used to label macropinosomes and lysosomes.
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PMC11172027
After 48 h, 125 µg/mL NASeLM showed a significantly better reduction compared to the NALM sample at p = 0.005, 200 µg/mL NASeLM at p = 0.003, 250 µg/mL NASeLM at p = 0.0004, 375 µg/mL NASeLM at p < 0.025, and 500 µg/mL NASeLM at p = 0.005, respectively, compared to the same concentration of NALM.
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PMC11770199
Sample comparisons were performed using multiple t test corrected by FDR.
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PMC7433824
One recent study proposed that P4‐induced growth suppression in GBM cells mainly occurred via suppression of glycolytic pathways and inducing senescence.
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PMC10887351
Stress, chronic depression and social support might affect cancer initiation and progression , and β-ARs could be involved in these processes .
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PMC11678841
By using the MTT assay to monitor cell viability, we found absence of toxicity for GA in the concentration range 1–100 µM in vaginal epithelial cells, whereas α-TOH showed a significant decrease in cell viability only at a 100 µM final concentration, suggesting the potential toxicity of exposure to pharmacological levels of this molecule (Figure 1).
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PMC11806106
Except for a recent study employing single-molecule FRET to study MOR conformations using chemically labeled purified receptors, to our knowledge, no FRET- or BRET-based reporter system directly reporting conformational changes of receptors has been established for the opioid receptor family.
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PMC10965315
The primary mechanism of action of harmaline and related ingredients is that they inhibit monoamine oxidase (MAO).
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PMC10808409
A D-optimal design with three factors was used to study the effects of the different factors on the polymeric mixed micelles characteristics, using Design Expert® software (Version 10, Stat-Ease Inc., Minneapolis, MN).
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PMC11391695
Furthermore, these nanocomposites exhibited a more proficient targeting capability compared to Cy3/pcDNA/PEI/NPs, thus exposing the HCC cell membrane’s exceptional biocompatibility (Fig. 5D, E).
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PMC9341513
In Z-138 cells, CCND1 expression shows an even larger 1200-fold increase compared to GM12878 (qPCR data shown in Supplemental Fig. S3C); LTO1 and TPCN2 also show increased expression in Z-138 compared to GM12878 cells, but we did not detect MYEOV expression.
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PMC11349530
This combination therapy caused more side effects like hypertension, mucositis, proteinuria, and diarrhea, than monotherapy, however, these side effects were manageable and well-tolerated (104).
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PMC11075223
In Qingwei Powder, Cimicifugae Rhizoma not only played a role in clearing heat and detoxifying to relieve symptoms such as stomach fire and toothache , but also used as a channel ushering drug to assist guiding various medicinal herbs to reach the affected site.
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PMC11502962
The clinicopathological characteristics are shown in Table 1 .
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PMC11740207
These cells demonstrated the capacity to SD, differentiate into various cell types, and initiate tumor growth in vivo when transplanted into animals, exhibiting traits similar to neural SCs.
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PMC9429973
Image: Summary/Conclusion: In conclusion, our results provide pre-clinical support for combining IR and TFG-β ligand-trap strategies for the treatment of BT, and also evidence that the modes of action of these two drugs act indefependently.
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PMC10745221
PRMTs are generally overexpressed in cancer, and this study showed a direct comparison of proteins with SDMA and ADMA within various cancer cell lines.
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PMC11794568
CRIP1 inhibits proliferation and invasion of cutaneous melanoma cells by suppressing TFAM-mediated mitochondrial biogenesis. (
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PMC10809689
Therefore, there is a need to use new treatment strategies and reconsider past treatments.
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PMC9429973
During the meeting, experts analyzed the disease burden, the current conditions for disease management, and access to treatment in the region.
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PMC8540611
AuNP13 had a low efficiency in all cases, the maximum uptake being 8.7 ± 0.9% for HeLa cells after 3 h incubation.
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PMC9429973
Therefore, novel therapeutic strategies to overcome HDACi resistance are required.
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PMC11745600
Blood glucose levels of Ins1 NOG started to decrease from 4 wk in female mice and 6 wk in male mice after transplantation and reached an almost human glycemic set point (<100 mg/dL) at 9 wk in female mice and 12 wk in male mice.
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PMC11543935
This results in a overall expanded treatment time with the IGEA device.
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PMC11190538
Data are expressed as Mean ± SD.
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PMC10595704
They also induced a marked increase in reactive oxygen species (ROS) production in a dose-dependent manner.
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PMC10523483
H1.2 deficient NSCLC cells were more vulnerable to oxidative stress. (
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PMC5417661
We conclude that NOV202 and paclitaxel possess similar capacity to induce M phase arrest in different OC cell lines but the outcome of the cell cycle delay varies in a cell line dependent manner.
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PMC4277423
The HA-tag was to facilitate detection and the NLS (nuclear localization signal) was to target the Cas9 protein to the nucleus.
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PMC10840195
Changes in the fluorescence area of tumour cells in different groups are shown in figure (A), and the tumour fluorescence area was measured by ImageJ (B) EMT is a reversible developmental process.
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PMC9878562
The involvement of LTB4 in the recruitment of neutrophils in combination with other chemoattractants to inflamed joints was also shown (65, 66).
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PMC10297204
It is medically utilized for the disinfection of skin and surgical sites .
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PMC9429973
Pts with unavailable data on IPSS-R risk or HMA tx were excluded.
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PMC9847912
The cultures were then treated with 25.5 μl per well of appropriate dilutions of GSK232 (or molecular-grade water for solvent-only and no-DNA controls) and 10 μl per well of 420 μM chloroquine diphosphate salt (for all culture wells) and returned to the incubator.
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PMC9429973
Within the different MDS entities SF3B1 mutations were favorable in MDS-RS-SLD (median OS: 106 vs. 25 month; p=0.009), MDS-RS-MLD (median OS: 82 vs. 64 month; p=0.049) and MDS-EB-2 (median OS: 129 vs. 25 month; p=0.011), but were associated with shorter survival in MDS with isolated del(5q) (median OS: 69 vs. 79 month; p=0.044).
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