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BioData-CellLine_annotated

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PMC11792766
Their study conducted cytotoxicity experiments on three malignant rat hepatocyte cell lines, exposing them to ethanol concentrations ranging from 0% to 50% v/v for 0.25–60 min.
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PMC10158546
The ReN 129 M and 129 V cell lines had very similar levels of PrP expression (Figure 3a).
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PMC11489351
There was no significant difference in cell viability between control MCF10A cells and cells with decreased (EIPA) or increased pHi (NH4Cl) under these treatment conditions (Fig. 1C).
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PMC11363012
Notably, although a few leaf and root cells accumulated catharanthine (6) to concentrations over 100 mM, the maximum concentration of catharanthine (6) that can be reached in solution (pH 5, the expected pH of the vacuole) is about 20 mM (see the Experimental section).
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PMC11535726
Individual sequences were aligned using MAFFT version 7 (https://mafft.cbrc.jp/alignment/server/index.html) with the “auto” option (Katoh et al. 2017).
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PMC11320084
However, the effect of TNNT1 on LC metastasis in vivo has not been further verified by animal experiments and needs to be further improved.
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PMC11679326
Malignantly transformed cells are characterized by significant variations in the glycosylation profile of cell membranes, forming localized areas of high-density carbohydrate clusters on the surface of tumor cells recognized by carbohydrate-binding proteins and thus mediating the modulation of cellular signaling, leading to tumor cell growth, migration, invasion, and chemoresistance .
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PMC11680578
Moreover, synergism treatment can improve the efficiency of the treatment and reduce the development of drug resistance.
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PMC11011837
In this context, few studies on the lipid composition of T cells have been reported in the literature, which were mainly interested in T cells isolated from blood rather than immortalized cell lines or tumor models.
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PMC11222184
SLC2A1 encodes GLUT1, a glucose transporter involved in the metabolism of glucose, which provides an energy source for cell proliferation and contributes to cancer progression and development .
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PMC11574271
Considering these facts, it is essential to understand the cellular mechanisms underlying malignant behaviors of advanced bladder cancer cells, including their migration and invasiveness capabilities.
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PMC9985266
The samples were observed with a confocal microscope and photographed for analysis.
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PMC11738017
Anti-BCMA TCE cytotoxicity is dependent on the ratio of T-cell engagement per mBCMA molecules that is factorized by the combinatorial effect of sBCMA, mBCMA, E:T ratio, and TCE dosing.
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PMC10565698
Xiang Chen: Conceptualization, Data curation, Methodology, Project administration, Software, Supervision, Validation, Writing – original draft.
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PMC11541241
RIM15‐mediated phosphorylation of glutamate dehydrogenase activated the TOR signalling pathway and eventually inhibited autophagy.
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PMC11587606
The findings support the view that RHBDF1 overexpression, as it is often observed in clinic breast cancer tissues, may facilitate the loss of apicobasal polarity in mammary gland epithelial cells during early stages of breast tumorigenesis.
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PMC9545714
RNA concentration and purity were determined using a Nanodrop IMPLEN spectrophotometer (Westlake Village).
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PMC9429973
Preplanned subgroup analyses showed that MMR rate at wk 96 was consistently higher with asciminib than BOS in all demographic and prognostic subgroups, including all prior lines of TKI therapy, and regardless of the reason for discontinuation of the last TKI (Figure).
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PMC9429973
Aims: To design an in vitro CLL culture system that incorporates key aspects of the CLL LN; contribution of non-CLL cells and cytokines, and induction of drug resistance and prolonged proliferation of CLL cells.
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PMC11763111
p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001; ns, not significant LLT1-overexpressing UCAR-T cells demonstrate potent anti-tumor activity in humanized T-ALL models.
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PMC10490530
The photon output of hLuz was at least 8-fold higher than native Luz in the MCF7 cancer cell line (p = 0.0006) (Supplementary Figure S2).
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PMC5311252
Previous studies have described connections between all individual oncomotif-miRNA containing miRNA clusters and cancer as exemplified by miR-17~92 cluster in lymphoma, miR-106a~363 cluster in T-cell leukemia, miR-106b~25 cluster in gastric cancer, C19MC cluster in CNS-PNET, miR-371~373 cluster in testicular cancer and miR-302~367 cluster in germ cell tumors.
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PMC8751435
CME, one of well‐known dietary therapy, could serve as a complementary medicine in anticancer treatment.
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PMC11532793
Figure 1b shows that bootstrap and Gibbs RTA-dispersions both tend to decrease with count size.
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PMC11243198
Further studies are required to assess the stability and the solubility of the selected GANT61 analogs (BAS 07019774 and Z27610715) compared to GANT61.
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PMC11774251
An imiquimod (IMQ)-induced psoriasis-like mouse model was treated topically with Tan-I (7.5 mg/kg/d) or a vehicle.
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PMC11583010
Furthermore, there are reports suggesting that lower affinity antibodies resulted in ADCs with higher tumor penetration and accumulation and thus better therapeutic activity (26, 27).
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PMC11653168
Mice were placed into a euthanasia chamber, which was gradually filled with CO2 at a flow rate of 30% volume/min.
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PMC10777969
This includes a screening cytotoxicity analysis aimed at selecting the most responsive cancer cell line and a selection of compounds with anticancer potential for further investigation.
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PMC11786767
We found that either the methanol or acetone treatment reduced DHPE-biotin signals by more than 70% when compared with PFA fixation alone (Fig. 1B and C, upper).
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PMC11442172
Furthermore, Ludikhuize et al. (64) investigated the 5-FU response in PDTO models mimicking the different CRC stages.
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PMC11572213
We also found that GLUL expression and P-AMPK-α protein levels were increased in TET2-downregulated HL-60 cells in low glutamine concentrations.
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PMC11543853
Blocking endosome acidification with bafilomycin A1 reduced the number of particles that released their genomes, but did not prevent them from reaching the cytoplasm.
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PMC11791432
Bulk transcriptome sequencing showed that the expression of ANXA1 was upregulated in glioma tissues and correlated with clinical events at the individual level (including tumor progression, recurrence, chemo- or radio-therapy response, overall survival, etc.).
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PMC11297139
Taking advantage of this resource, we explored the protein levels of ARID1A across multiple types of cancer, and found that ARID1A protein level was significantly high in Ewing’s sarcoma compared to many other cancer types (Fig. 3a).
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PMC11665584
They confirmed that oral keratinocytes migrate and proliferate much faster than skin-derived keratinocytes.
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PMC10994876
This assay was performed twice for accuracy.
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PMC11534035
Photos of representative gaps in A431 (C) and CAL39 (D).
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PMC9844987
TFs associated with highly variable promoters are mostly related to tissue-specific or developmental regulation (e.g., FOXP2, HOXA10) while TFs predictive of low promoter variability are generally associated with ubiquitous activity across cell types and a diverse range of basic cellular processes (e.g. ELK1, ELF4, ETV3).
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PMC6379402
We are increasingly accumulating molecular data about a cell.
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PMC6684588
In this semi-quantitative assay, ACE-083 displayed a concentration-dependent affinity for Matrigel® markedly exceeding that of FST315-Fc (Fig. 1b).
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PMC11680982
For HER2-low cells: ET + 100 nM CDK4/6i + 125 nM neratinib, CI = 0.34; ET + 200 nM CDK4/6i + 250 nM neratinib, CI = 0.34; ET + 400 nM CDK4/6i + 500 nM neratinib, CI = 0.23; ET + 800 nM CDK4/6i + 1000 nM neratinib, CI = 0.46; ET + 1600 nM CDK4/6i + 2000 nM neratinib, CI = 0.29. (
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PMC10976516
The latter effect is mainly due to OV’s susceptibility to factors of the innate and adaptive immune systems such as complement proteins, antibodies, and the reticuloendothelial system that surveys the blood circulation for oncolytic virions.
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PMC9429973
In 10/18 patients, known recurrent chromosomal translocations affecting the oncogenes TAL1 (3x), LMO2 (3x), TLX1 (2x), TAL2 (1x) and MYC (1x) were identified.
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PMC4695073
The H score that was closest to the point with both maximum sensitivity and specificity was selected as the cutoff value (H score = 1.40), and defined high XPA expression while H score ≥ 1.4 and low XPA expression while H score < 1.4.
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PMC10170482
Therefore, we hypothesized that mechanically modulated metabolic rewiring of liver tumor cells should be linked to the proliferation and dormant state of cell.
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PMC10726501
P<0.05, **P<0.01
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PMC10197932
CD69 regulates the differentiation of regulatory T (Treg) cells and secretion of some cytokines such as IFN-γ, IL-17, and IL-22.
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PMC11513571
In addition, TSLP protein levels peaked at 48 h (Figure 3A).
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PMC8913139
The overall prognosis of GBM patients is poor .
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PMC11768927
This approach potentially enhances the efficacy of VSV-based oncolytic therapies, allowing for improved targeting and destruction of tumor cells.
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PMC11295144
While the incorporation of the β subunit is required for the expression of GABAARs at the neuronal cell surface (Connolly et al., 1996a,b; Nguyen and Nicoll, 2018), some α subunits are selectively assembled at specific inhibitory synapses where they support the formation and function of neuronal circuits involved in specific brain physiology, such as anxiety, sedation, arousal, and others (Klausberger et al., 2002; Rudolph and Mohler, 2006; Thomson and Jovanovic, 2010).
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PMC11345828
-34: LCMS Method 2: RT = 1.281 min, MS (ESI): m/z 539.2 (M + H), H NMR (400 MHz, CDCl3) δ 7.63 (d, J = 8.8 Hz, 1H), 7.24 (d, J = 8.8 Hz, 1H), 6.63 (s, 2H), 5.73 (d, J = 5.2 Hz, 1H), 4.23–4.20 (m, 1H), 4.02–3.97 (m, 2H), 3.85 (s, 3H), 3.82 (dd, J = 21.2, 8.4 Hz, 1H), 3.44–3.28 (m, 2H), 3.19 (ddd, J = 12.8, 5.6, 1.6 Hz, 1H), 2.33 (s, 6H), 1.96 (s, 3H), 0.96 (d, J = 6.4 Hz, 3H).
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PMC11742290
MicroRNAs and other non-coding RNAs potentially can bind to LGR5 mRNA and suppress its translation into protein without degrading the mRNA .
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PMC8414691
RNAi treatments were carried out according to Somma et al. .
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PMC11478724
As mentioned above Hsa-MiR-320a regulates both direct and indirect target genes to achieve its biological effects, which include inducing apoptosis, blocking metastasis, and decreasing proliferation.
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PMC9429973
Methods: We developed in vivo patient-derived xenograft (PDX) NOD/SCID/IL2Rγc-deficient (NSG) mouse models mimicking MRD by 1) intravenous (IV) injection of primary AML diagnosis samples and, as soon as leukemic cells were detectable in the peripheral blood, treatment with combination chemotherapy, and 2) IV injection of AML patient samples at the stage of MRD in NSG mice.
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PMC11786767
The original regions of the enlarged images are indicated only in the rightmost panels.
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PMC9454178
We found that CDK7 knockdown resulted in marked cell cycle arrest at the G1/S phase (Fig. 2D).
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PMC9220170
Next, it was used to first prepare the base layer of agarose (0.8%): 1.75 mL of agarose stock solution was mixed with 5.25 mL of culture medium per 30 mm dish.
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PMC8382973
Written informed consent was obtained from the owners for the participation of their animals in this study.
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PMC11686380
Fig. 1Clinical and genetic features of the proband (A) The proband’s radiograph of the left hand at 10 years showing the 4th finger valgus and the 5th finger shortened and curved. (
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PMC11548041
At the completion of MD, simulations interactions diagrams were generated, and the raw data were extracted.
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PMC11055510
In addition, phosphorylation levels of TAK1 increased in overexpressed circMAN1A2 and decreased in silenced circMAN1A2 in OC cells and in vivo tumors.
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PMC9429973
There are significant correlation between low level of protein S and duration of hospitalization in ICU department, rho=-0.367 (-0.541- -0.163) p=0.0007.
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PMC10335954
Ten replicates were performed in each group in the in vivo experiment above.
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PMC11615218
These senescent T cells were KLRG1CD57CD160CD28, had low levels of PD-1 and CTLA4 phenotypes, and had normal telomere lengths .
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PMC11509278
L-palmitoylcarnitine was also downregulated in this study, which is consistent with the detection of metabolites of breast cancer cells inhibited by berberine in the hypoxic microenvironment .
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PMC11225860
Treatment was then withheld for two weeks followed by another five-day-a-week treatment cycle.
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PMC11705547
In addition, cisplatin can enhance the infiltration and activation of DCs by upregulating IL-10, thus further activating a robust anti-tumor immune response and improving treatment outcomes .
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PMC11361748
To quantify TUNEL-positive cells, the number of positively stained cells was counted as well as the total number of cells based on DAPI staining.
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PMC11666785
B Alongside localization precision plot is also displayed.
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PMC11757131
After discarding the Triton X-100 and washing twice, 100 μL of Click reaction solution from EdU Cell Proliferation Detection Kit was added to each well and incubated for 30 min.
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PMC9268183
In general, the presence of phytochemicals and antioxidants in Rosaceae fruits and their potential as cancer inhibitors are well known , but based on our results, investigating alternative tissues could indeed open new avenues in this field of research.
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PMC9479186
NDUFC1 is negatively stained in non-cancerous tissue (left) and is positively stained in HCC specimen (right). (
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PMC11334037
We found that OE-IGF2 promoted the GIST-T1 cell metastasis in vivo, showing a significant decline in the number of liver metastatic nodules (Figure 2G and H, P < 0.01).
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PMC9429973
Concerning the clinical severity at presentation, the frequency of TGF-beta (82% vs 58%, p=0.01) and IL-10 (17% vs 5%, p=0.03) high producers was higher in patients with Hb ≤7.5 g/dL (median of all AIHA) versus those with less severe presentation.
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PMC5673955
Calculation of activity was assessed for 1 × 10 cells based on the calibration curve obtained with commercial b‐Gal (Abcam) in the range 0.01–100 U/mL. Statistical analysis involving Student's t‐test was implemented with the Statistica 6.0 software (StatSoft, Tulsa, OK).
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PMC11747949
This surface protein, helps cancer cells to survive in hypoxia by maintaining the physiological pH in cancer cells and acidifying the TME (Pastorekova and Gillies 2019).
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PMC3274243
To demonstrate that this electrochemical technology is applicable to different adherent cell types, OCP values have been monitored in experiments involving a variety of cell lines.
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PMC11055510
RT-qPCR analyzed the effect of miR-135a-3p inhibitor interaction with si-IL1RAP on IL1RAP expression in A2780 cells. (
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PMC11720808
The cells were incubated in a humidified atmosphere with 5% CO2 at 37°C.
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PMC11782508
FTIR spectrum. (
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PMC11750712
Effector mock and CAR-transduced T cells were labeled with CellTrace Violet (C34557, Thermo Fisher Scientific) following the manufacturer’s instructions.
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PMC10142392
However, cylindrical micelles were observed when the PCL arm length was longer (fPEG = 0.15–0.32).
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PMC11766309
Therefore, we investigated the correlation between YKT6 and major immune checkpoint genes (Figure 10C).
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PMC11049548
As cancer causes significant metabolic alterations to sustain its growth, metabolomics mass spectrometry and nuclear magnetic resonance (NMR) approaches have been widely applied to learn about the biochemistry of cancer cells .
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PMC9429973
People affected by the most severe transfusion-dependent (TDT) form of the disease require lifelong blood transfusions (BT), treatment associated to several complications.
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PMC11629461
Asterisk indicates p < 0.05.
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PMC9429973
30% of patients (27/89) had received ≥1 RBC transfusion prior to dosing.
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PMC9429973
8/20 (40%) patients with a home supply of strong opiates were admitted to CUH with an acute sickle cell pain crisis in 2021 compared to 5/26(19.2%) in those who did not have strong opiates at home.
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PMC11770130
The genome-wide association study (GWAS) summary statistics of plasma ceramides levels were obtained from PheWeb Datasets (https://pheweb.org/metsim-metab/).
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PMC11638255
g Dot plot of gene expression markers used to classify the immune subsets defined in (e).
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PMC9065483
At first glance, increased NF-κB signaling by vanadate appears to be counterintuitive for oncolytic potentiation as other established viral sensitizing compounds such as dimethyl fumarate (DMF) operate by inhibiting NF-κB nuclear translocation.
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PMC11609529
Following extensive washing, cells were stained with DAPI (Vector Laboratories H-1500) and mounted on slides for imaging.
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PMC11323699
Connective lines (red for increased, green for decreased) link samples from the same patient to illustrate changes after treatment.
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PMC8382973
These data indicate that despite the efficacy of condoms, condom failure occurs in gay men exposed to HIV (9).
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PMC9739791
The prodrug can be activated even in the absence of reducing agents and its cytotoxicity mechanism differs greatly from that of oxaliplatin, which indicates that the prodrug could overcome resistance to conventional platinum drugs.
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PMC11525028
Gene expression data of patient samples were listed in Table S9.
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PMC11402217
The established treatment protocol for OS includes neoadjuvant chemotherapy, surgical resection, and adjuvant chemotherapy.
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