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PMC9895440
Denaturized proteins and Precision Plus Protein Dual Color Standards (BioRad #1610374) were separated by SDS-PAGE and later transferred to a PVDF membrane (Immobilon-P, Sigma #IPVH85R) at 100 V for 60 min in tris/glycine buffer (BioRad #1610771) supplemented with 20% methanol.
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PMC11098378
Fractions containing Ceg10 were concentrated of 20 mg/ml and filtered with a 0.22 μm Durapore membrane filter.
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PMC3765139
Inconsistently with findings published by Fang’s group , CD133+ D10 cells had not upregulated the expression of ABCG2 (ATP-binding cassette, sub-family G (WHITE), member 2A), which was identified to be overexpressed in primary or metastatic melanoma compared to benign melanocytic nevi .
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PMC9429973
Haematopoiesis of symptomatic mice was analysed by flow cytometry and histology.
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PMC11509278
A Hypersil Gold column (C18, 100 × 2.1 mm, 1.9 μm, Thermo Scientific, Waltham, MA, USA) with mobile phases A (0.1% formic acid) and B (methanol) was employed.
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PMC11562028
Due to the low sensitivity of kidney cancer to chemotherapy drugs, besides the resection surgery, immunotherapy (such as PD-1 antibody) can also prevent the proliferation and spread of kidney tumors.
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PMC11087301
Metastasis is a critical hallmark of cancer that involves a complex interplay of molecular events, with tissue invasion being a crucial initial step in the process .
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PMC11684821
These T cells were able to respond to WT levels of MR1 on a wide range of cancer cell lines from many different origins but remained inert to healthy CD14 monocytes and B cells from multiple individuals.
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PMC11347429
Only few DEGs were found in both comparisons.
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PMC8557138
Also, various factors such as shear stress and interactions of blood constituents with the cells of the vessel significantly influence the vascular tone and functionality of the surrounding ECs.
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PMC11740399
Inhibitors of caveolin-1 (filipin), alongside Dil-labeled 3025@ML, were investigated to evaluate the uptake mechanism of these hybrid liposomes in bladder cancer cells via flow cytometry.
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PMC9429973
Predictors of survival After a median follow up of 6.6 months, 68 patients died and 9 underwent allogeneic stem cell transplant.
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PMC11423992
CHO-K1 cell line was purchased from the National Collection of Authenticated Cell Cultures (CCRID cat. #
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PMC9429973
Aims: To overcome the limitations of existing techniques, targeted next generation sequencing approach was tested in this study.
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PMC9621239
The proportions of cells with EdU staining in the Vector, WT, SM, DM and TM groups are presented at the right of the panel; Each symbol represents an individual experiment; Data are presented as mean ± SEM; Unpaired t test.
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PMC10092581
In vitro antitumor activity of Au(I) and Ag(I) selenourea complexes.
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PMC11680982
For HER2-low tumor inhibition rate on day 21: normal saline vs. medium-dose ET + CDK4/6i + Ner, P = 0.0217; normal saline vs. low-dose ET + CDK4/6i + Ner, P = 0.1271.
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PMC11740207
For example, DNA methylation patterns and histone modifications unique to transformed VSELSCs could serve as biomarkers for early diagnosis.
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PMC11711871
Overall, sodium and potassium homeostasis is maintained in both groups independent on the diet condition.
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PMC9841531
Table 1 provides the half-maximal inhibition concentration (IC50) values of compounds 17–32.
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PMC9429973
ORR in the entire cohort was seen in 98/176 (55.6%) patients.
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PMC9429973
However, in gram positive; Staphylococcus epidermidis 49 (51%) was more prevalent.
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PMC11721295
Cells tested negative for mycoplasma.
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PMC10882807
This study was approved by the Ethics Committee of Nantong Third Affiliated Hospital of Nantong University and were conducted in accordance with the Declaration of Helsinki.
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PMC11095939
not significant; ****p<0.0001 by one-way ANOVA. (
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PMC9261184
It is not known whether operating at 40% load for generator engines is a typical mode of operation across the LNG carrier fleet, and discussions with LNG carrier operators suggest that they can, and do, operate at higher loads, which would reduce slip.
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PMC10747160
The lentivirus solution was clarified by centrifugation at 105× g for 3 min and then filtered through a 0.45 µm sterile PES syringe filter (ThermoFisher Cat # 09-740-114, Waltham, MA, USA).
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PMC9429973
Y. Takahashi, A. Kitadate, S. Ikeda, S. Iwama, K. Abe, Y. Matsuda, H. Tagawa, H. Wakui, N. Takahashi Department of Life Science, Graduate School of Engineering Science, Akita University; Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Akita, Japan Background: Histone deacetylase inhibitors (HDACis), such as vorinostat and romidepsin, are promising agents for various T-cell lymphomas, including cutaneous T-cell lymphoma (CTCL), peripheral T-cell lymphoma, and adult T-cell lymphoma/leukemia.
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PMC10154881
Viral growth of rMV‐SLAMblind in E.G‐7/N4 (left) and B16/N4 (right) cells.
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PMC11711127
Indeed, this could explain early reports that the longevity of transplant tolerance is improved following depletion of the host T cell repertoire (186).
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PMC11640555
Furthermore, through the GBM xenograft model, the antiproliferative role of CX-4945 will be investigated, providing further evidence that CK2 inhibition could influence the GBM microenvironment also restoring the BBB stability directly involved in brain tumor progression and thus reducing the tumorigenic power of GBM.
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PMC11267830
After solidification of the bottom gel layer, the top layer of gel and cells were added.
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PMC11803149
2 x 10 cells (in 100 μL PBS) were subcutaneously injected into the right flank of mice.
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PMC11371747
This study also shows that mechanisms of folate transport and metabolism can efficiently be studied when using adequate in vitro models, in contrast to most in vivo models.
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PMC10988808
A significance threshold for KEGG pathway enrichment was established at p < 0.05.
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PMC10587429
All in all, with individual cancer type and specific tumor microenvironment taken into account, the current humanized orthotopic mouse model can be modified for other pediatric and/or bone cancers.
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PMC11476106
VN cross-linking in HGs did not prevent VN secretion by ES cells, which remained elevated despite the large quantities present in the scaffold.
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PMC11637284
The importance of ionic bonds for TAC60-p166 interactions was experimentally tested by three TAC60 variants in which either R181 and/or E189 were mutated.
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PMC11770199
B and C) CCK8 analysis of killing effects of hMSCs-p14 on HCT8 and A375.
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PMC10898159
BRD4 (function as “readers”), HAND1 and BRAX1 positive regulate the core TF network.
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PMC11543885
Wash the beads twice with 1 mL RIPA lysis buffer per samples (in each wash step, rotate the tube 2–3 times and pellet the beads on magnetic rack for 1 min incubation time).
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PMC9429973
The median (Me) OS for patients with post induction negative MRD (MRDneg) was 61.2 (CI95% not evaluable) versus 25.9 months (CI95% 2.5-49.2) with positive MRDpos, p =0.03.
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PMC11621493
Fig. 9L).
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PMC11306331
Droplet formation in the dark was slower than droplet dissolution in the light, occurring with a characteristic timescale of ~110 seconds (Fig. 2F).
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PMC10568263
However, fitting EIS data involves using an appropriate equivalent circuit, and in this case, the Randles equivalent circuit is composed of four components, including (i) charge transfer resistance (Rct), (ii) Warburg impedance (ZW), (iii) solution resistance (Rs), and (iv) constant phase element (CPE), as shown in Fig. 7(b) inset.
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PMC11696576
EC50 values were calculated by fitting the % inhibition data to a three-parameter dose-response curve in GraphPad prism v10.4.0.
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PMC9429973
Four pts were exposed to daratumumab (triple-class exposure).
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PMC11638288
These ILC1 cells release cytokines such as CSF2 (granulocyte–macrophage colony-stimulating factor), which enhances the proliferation and activation of monocyte-derived macrophages.
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PMC9429973
Image: Summary/Conclusion: Treatment of HGBL-DH/TH patients with DA-EPOCH-R results in a shift towards a lower CD4/CD8 ratio.
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PMC9429973
Overall response was observed in all retreated patients.
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PMC7642379
Although the MSMO1, IDI1 and HMGCS1 genes were all up-regulated in 293-F and 293-H compared to HEK293, the down-regulation of the lathosterol oxidase gene (SC5D), which gene product is in downstream steps of the pathway, resulted in a predicted reduction in cholesterol production in 293-F and 293-H cells compared to HEK293 (Supplementary Fig. S7).
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PMC6442998
Transcriptional quantification relative to GAPDH and β-actin reference genes was performed using qBase+ software (Biogazelle, Zwijnaarde, Belgium).
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PMC10772747
The lines indicate the mean ± SD values from three independent experiments. *
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PMC9429973
Aims: We evaluated the efficacy and safety of low-dose metronomic cyclophosphamide in patients with low grade non-Hodgkin lymphoma (NHL) by retrospectively reviewing the data.
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PMC11348300
Recent reviews of ongoing clinical trials indicate that there are >940 ongoing trials, of which nearly half use ICG and the others use various forms of molecular targeted fluorophores (3, 14).
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PMC6461034
Additionally, INKA scores of MAPK pathway members MAP2K1, MAP2K2, MAPK1, and MAPK3 were reduced, indicating ALK‐MAPK network crosstalk.
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PMC9318744
To test this, we used the 614D and 614G strains of S-pseudotyped lentiviral particles to infect ACE2plusC3 cells.
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PMC11462673
S6A-C and Fig. S7A-B, Supplementary Table 10, 11, 12).
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PMC10490530
Thus, until now, limited resources of non-cross-reacting Luciferase:Luciferin pairs kept the scope of multiplexed BL reporter-based assessment implausible.
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PMC9429973
Our previous analysis of whole BM mononuclear cells (BM-MNC) has revealed distinct expression patterns of inflammasome-related genes, including IL1B and IL18, to be associated with LR-MDS subgroups and clinical features.
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PMC3734024
The Fas/FasL signaling axis is critical for the maintenance of self-tolerance, as mice bearing natural mutations in genes coding for these molecules develop spontaneous systemic autoimmunity , .
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PMC7185206
Here we uncover a novel mechanism of ADAM10- and ADAM17-mediated resistance to PD-(L)1 inhibitors.
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PMC11742431
The complete methods of bioinformatics analysis, vector construction and protein expression, western blot, EGFP fluorescence intensity assay, protein internalisation assay, characterization of the working proteins, Furin protease cleavage analysis in vitro, MTT assay, cell apoptosis assay, cloning formation assay, cell migration assay, cell viability assays, indirect immunofluorescence assay, 3D tumor spheroid growth inhibition, and in vivo antitumor efficiency can be found in the Supporting Information.
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PMC11519583
These findings indicated that Ror2 is required for MP proliferation, adipogenic differentiation, and inhibition of cellular senescence.
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PMC8751435
Conclusively, our data provided basic insight into role of caspase‐3/TET2 in survival or death switch after CME treatment, and it will be beneficial to define regulating network for pyroptosis and refining CME.
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PMC11394112
Our results showed that human IL6-expressing NSG (NSG-IL6) mice were highly permissive for DLBCL cell growth.
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PMC11519077
Given epigenetic alterations in oncogenes and other tumor suppressor genes, tumor transformation and progression may be produced.
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PMC10547921
More than half of the ADCs currently in clinical development have tubulin inhibitors (auristatins and maytansinoids) as payloads.
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PMC11591038
HIF-1α is also known to be activated under oxidative stress, neuroinflammation, and cerebral hypoperfusion, the conditions often accompanied by AD.
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PMC11036064
Consistent with this, hsa-miR-34a-5p significantly upregulates CASP8 and CASP9 expression and potentiates temozolomide-mediated CASP8 and CASP9 upregulation in A172 cells (all P-values < 0.0001) (Figure 9C, D(Fig.
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PMC11762280
To block UVB-induced apoptosis, we used the caspase-3 inhibitor Ac-DEVD-CHO to observe the effects (Fig. 4A).
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PMC11511922
Scale bar indicates 20 µm.
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PMC11650848
Eligible participants were randomised at the end of their first trimester to receive either 400 µg/day of FA (n = 96) or placebo (n = 94) until the end of pregnancy.
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PMC10040136
The GAPDH gene served as the loading control.
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PMC8662250
CBD (10 M) markedly counteracted occludin (+210% vs. SP 10 ng/ml group) and ZO‐1 (+150% vs. SP 10 ng/ml group) reduction, and its effect was dependent upon PPAR‐γ involvement, since no protective effect on tight junction recovery was obtained in the presence of GW9662 (9 nM), once again confirming the inescapable role of this receptor in mediating CBD protection in our experimental conditions (Figure 4c, d).
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PMC11745600
In addition, Ins1 NOG mice underwent insulin tablet implantation to investigate the potential for achieving sustained blood glucose level control.
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PMC11740907
Furthermore, in silico simulations which aids in improving drug delivery, ensuring precise targeting, and gaining a better understanding of the mechanisms behind the anticancer effects of POMs.
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PMC11763126
Additionally, paraffin-embedded RCC and adjacent normal tissues were obtained from 66 RCC patients for PCR and immunohistochemistry analysis.
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PMC10578720
once a day).
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PMC11257988
The most common mutation subtypes in KRAS-mutant lung adenocarcinoma are codon 12 substitution mutations (purine is replaced by pyrimidine or vice versa) G12C (39%) and G12V (18–21%), followed by transition mutations (purine is replaced by purine or pyrimidine is replaced by pyrimidine) G12D (14–18%) and G12A (10–11%).
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PMC10203589
It is also involved in cortical neuronal activity, cartilage and osteogenic development, and hair growth (25–28).
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PMC11803149
Data are representative of 2 independent experiments.
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PMC11301242
Blue data points represent the same genes encoded on ecDNA in the A3KAW cell line. (
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PMC9429973
Image: Summary/Conclusion: Ibrutinib plus venetoclax is an effective and well tolerated combination resulting in a high rate of MRD negativity in blood (71.9%) and marrow (65.4%) in the first 2 years of treatment.
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PMC8584319
MEFs (eIF2α S/S and eIF2α A/A) were cultured in 10% serum-containing DMEM medium containing MEM amino acid solution (50×, Gibco) and MEM non-essential amino acid solution (100×, Gibco).
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PMC10218459
Ewing’s sarcoma (ES) is the second-most-common bone tumor in humans and yet, with an annual incidence of up to 1.2 cases/million , a rare malignancy .
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PMC6803987
However, these drugs are prone to drug resistance and have side effects .
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PMC11098378
Despite this, both structural determinations overlap modestly (Fig 4D).
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PMC9429973
The correlation with clinical data showed significant differences among clusters in IGHV status, CLL activity (categorized according to therapy need), and an increase of absolute lymphocyte count (ALC) per month.
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PMC10213179
Data analysis was done using the global data analysis option available within BIAevaluation 4.1 software.
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PMC9672323
Tumor cells can suppress anti-tumor immune responses by secreting various factors as well as expressing surface inhibitory molecules; therefore, blocking these suppressive effects could ameliorate immune functions in the tumor microenvironment.
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PMC9429973
The F/M sex ratio was 0.1.
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PMC11391695
Among them, KCNN4 has been extensively researched in a diverse array of physiological processes, including immunomodulation, cell proliferation, and apoptosis .
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PMC11754432
Acquisition and airyscan processing was performed using Zen Blue software.
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PMC9429973
Methods: We have analyzed the data of 99 patients (pts) with HGBLs that have been treated since 2010 till 2022 years.
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PMC11046454
Flow cytometry of the T cell population in PBMCs of tested mice sacrificed on day 42. (
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PMC11718031
For fed-batch experiments, 6% feed (v/v) was added on days 4, 6, 8, 10, and 12 and then harvested on day 14 or when viability < 80%, whichever is earlier.
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PMC11746948
The animals will be euthanized immediately if they are unable to stand or if they display agonal breathing, severe muscular atrophy, severe ulceration, or uncontrolled bleeding.
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PMC10006224
Next, we intersected these peaks with anchors of gained, lost and shared loops.
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PMC9019892
Interestingly, the phosphorylation of histone 2A family member X (γ‐H2AX) , which is an indication for DNA injury, was remarkably increased in this experiment (Fig. S5).
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