OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC9596868	Using the StepOne™ Real-Time PCR System (ThermoFisher Scientific) samples were incubated for 30 min at 30°C followed by initial activation at 95°C for 10 min and amplification by 40 PCR cycles with 15 s at 95°C and 60 s at 60°C conditions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11599565	The paraneoplastic protein MA1 (PNMA1) (K & O) is also detectable in SKOV3 ovarian carcinoma cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "B-CellLine", "I-CellLine", "I-CellLine", "O" ], "tokens": [ "The"...
PMC9429973	These individuals often have unanswered questions about living with or treating multiple myeloma.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "individuals", "often", "have", "unanswered", "questions", "about", ...
PMC8316344	Next, we investigated how TRIB2 reduces labile iron in liver cancer cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Next", ",", "we", "investigated", "how", "TRIB2", "reduces", "labile", ...
PMC10978090	HIPA + PF4 remained negative until D22.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HIPA", "+", "PF4", "remained", "negative", "until", "D22", "." ] } ]
PMC11348300	Concurrently, there is minimal change in PpIX fluorescence intensity in the blood during this period, suggesting negligible presence of PpIX in the blood.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11609529	Therefore, we successfully detected the endogenous YM fusion transcript and protein in ES-2 ovarian cancer cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", "we", "successfully", "...
PMC10810426	Shown is the average ± SD.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Shown", "is", "the", "average", "±", "SD", "." ] } ]
PMC9688728	After processing the initial data under the indicated conditions, in all tiles, the hits with the maximum area difference between days of cultivation (F-ratio > 5) were accepted for further analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11266100	The gating strategy illustrates transfected cells analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "gating", "strategy", "illustrates", "transfected", "cells", "analysis", "." ] } ]
PMC10317042	E, Genome browser screenshot of the epigenome maps at EWSR1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "E", ",", "Genome", "browser", "screenshot", "of", "the", "epigenome", "maps", "at", ...
PMC11763111	In order to evaluate the protective impact of LLT1 overexpression, CAR-T cells and purified CD3CD56 primary NK cells were co-cultured for 24 h at different E : T ratios (Fig. 5C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6160470	Inlet shows representative flow cytometry histograms of A2780/Adr cell line treated with 10 µM concentration of compounds as indicated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Inlet", "shows", "representative", ...
PMC11411004	Treatment with 2 μM I-4 was most effective in increasing monoclonal antibody production.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Treatment", "with", "2", "μM", "I-4", "was", "most", "effective", "in...
PMC11422497	The cumulative evidence indicates that miR-494-3p serves as one of the functional target miRNAs of circ_SMA4, manifesting a miRNA sponge effect.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10092581	As previously reported, LoVo OXP cells (derived from LoVo cells grown in the presence of increased concentration of oxaliplatin) were about 13‐fold more resistant to oxaliplatin than parental cells.	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O"...
PMC11789597	Moreover, cytokines regulated by CAV1 were examined using a cytokine array (Figure 2F).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Moreover", ",", "cytokines", "regulated", "by", "CAV1"...
PMC11658074	The specific reagents, instruments, and operations used are listed in the supplementary information.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "specific", "reagents", ",", "instruments", ",", "and...
PMC11518702	In addition, in HGAL isoform B, its polybasic cluster is disrupted by Ser10 replacing Arg10 (with Arg10 shifting to Arg12).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11092382	It has been shown that in a mouse model of isoproterenol (ISO)-induced kidney injury, sophocarpine could alleviate kidney injury by reducing the serum levels of serum creatinine (SCr) and blood urea nitrogen (BUN), inhibiting inflammatory cytokine release, preventing fibrosis, and reducing apoptosis and oxidative stress.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9219615	Pyrazoles are 5-membered heterocycles that contain three carbon atoms and two adjacent nitrogen (Figure 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Pyrazoles", "are", "5-membered", "heterocycles", ...
PMC11473750	Differences in cell growth were compared to Control siRNA transfected cells. ***	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Differences", "in", "cell", "growth", "were", "compared", "to", ...
PMC11684297	Guidelines in drug delivery literature commonly classify nanoparticle dispersions based on their zeta potential values as follows: ±0–10 mV as highly unstable, ± 10–20 mV as relatively stable, ± 20–30 mV as moderately stable, and > ± 30 mV as highly stable .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Image: Summary/Conclusion: To our knowledge, this is the first report of EV protein content from a real-world MGUS and MM patient cohort followed for more than 2 years.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11783017	Schematic illustration showing the enhanced immune infiltration from cold tumor to hot tumor. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Schematic", "illustration", "showing", "the", "enhanced", "immune", "i...
PMC9429973	However, OS and EFS, better than adult ALL treated by adult protocol (OS= 14%, EFS=14% in previous local study) but less than describe in the literature.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11190538	Phosphatidylcholine's hydrophobic chains combine in an aqueous environment to form a hydrophobic bilayer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Phosphatidylcholine", "'s", "hydrophobic", "chains", "combine", "in", ...
PMC8557138	Yan et al. used HeLa cell-laden silk fibroin hydrogel implants in CAM models to show the induction of apoptosis mediated by conformational changes in the 3D structure of the hydrogel.	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11569208	In both scenarios, further investigation is warranted to cement the role of each respective PP in the IFN pathway and further our understanding of how the phosphatome interacts with the natural anti-viral response.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9841531	Dilution series of compounds 17–32 between 1 nM and 1 μM were prepared in DPBS (Cell Clone, Genetix Biotech Asia, New Delhi India), and 10 μL of each concentration was pipetted into a colorless flat-bottom 96-well microplate (SPL Life Sciences, Gyeonggi-do, Republic of Korea).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11543853	A selected virion is indicated by a green arrowhead.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "selected", "virion", "is", "indicated", "by", "a", "green", "arrowhead", "." ] } ]
PMC11757230	As in these studies, most reports of the anti-tumorigenic effects of MSCs involve immortalized LL cell lines, while studies reporting pro-tumorigenic effects have typically used primary LL cells derived from patients .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11777207	We tested whether blocking the ability of PD-L1 to bind to PD-1 on the surface of the DCs using αPD-1 pembrolizumab would impede DC migration (Fig. 1B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8357004	Total RNA extraction kit (TRIZOL reagent) and real-time polymerase chain reaction (RT-PCR) kits (qPCR MasterMix Plus for SYBR Green I dNTP) were obtained from Applied Biosystems Inc. (Foster, CA, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9844987	We find that expression variability can be largely explained by a promoter’s DNA sequence and its binding sites for specific transcription factors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", ...
PMC11627060	Our experiment investigated a NP-based drug delivery system.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Our", "experiment", "investigated", "a", "NP-based", "drug", "delivery", "system", "." ] } ]
PMC8382973	Before investigating whether the immune response after 2P23 gel rectovaginal application correlates with changes in the mucosal microbiome profile, we evaluated the bacterial composition similarities and differences in the rectal and vaginal compartments at baseline (Day 0 of 2P23 gel rectovaginal application).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11761919	Fig. 1Schematic diagram of in vivo experiment in chicken.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fig.", "1Schematic", "diagram", "of", "in", "vivo", "experiment", "in", "chicken", "." ] } ]
PMC11371747	Values are calculated from the separate ratios of (IC50 antifolate + LV/IC50 antifolate).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Values", "are", "calculated", "from", "the", "separate", "r...
PMC11682525	In light of these considerations, the present study aimed to assess the impact of hypoxic preconditioning on cell survival and tolerance to oxidative stress in two distinct categories of human cells: nestin-expressing hair follicle stem cells (hHFSCs) and SH-SY5Y neuroblastoma cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Central tendency measures were plotted against histological and clinical MAGIC (Mount Sinai Acute GVHD International Consortium) scores related to GI-GVHD and a multivariate analysis was performed to exclude confounding factors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9341513	The arrow shows the transcription start site.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "arrow", "shows", "the", "transcription", "start", "site", "." ] } ]
PMC11723947	We then tested the involvement of HP1γ in the susceptibility of allospecific Tconv to Treg-mediated suppression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "then", "tested", "the", "involvement", "of", ...
PMC6901583	After incubation, imaging of tube formation by microscopy and quantification the branch number in the formed HUVEC tubes were performed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O" ], "tokens": [ "After", "incub...
PMC9454178	Two researchers separately evaluated the staining level and divided the patients into high and low CDK7 expression groups (Fig. 1C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Two", "resea...
PMC10047551	A significant inverse correlation was observed between the methylation of cg19724470 and PD-L1 TPS (Figure 5B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "significant", "inverse", "correlation",...
PMC9429973	Regarding the patients diagnosed with SCD and MMS, MMS was diagnosed at 9 years old in one patient and at 10 years old in another.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9268620	One-way analysis of variance (ANOVA) was also used for multiple comparisons, where p < 0.05 was considered to be statistically significant.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10958426	We set the number of tumor subclones (k) from 6 to 2 and chose the largest k as the number of tumor subclones when each tumor subclone has unique CNV pattern in each patient.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11092418	Brain cancer is one of the deadliest and most lethal types of human cancers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Brain", "cancer", "is", "one", "of", "the", "deadliest", "and", ...
PMC11574271	Western blot analysis was employed to validate the expression of MMP12.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Western", "blot", "analysis", "was", "employed", "to", "validate", "the", "expression", ...
PMC10631132	A-L Representative images of 3 replicates display ALP-stained colonies and cell-forming complexes of a PBMC-derived cell line (A-F) and a fibroblast-derived cell line (G-L), showing high expression of ALP while expanding (A, B, G, H).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9712534	Original uncropped images are shown in Supplementary Fig. S4.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Original", "uncropped", "images", "are", "shown", "in", "Supplementary", "Fig.", "S4", "." ] } ]
PMC10669966	The tissues were counterstained with hematoxylin (Mayer’s, Cat.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "tissues", "were", "counterstained", "with", "hematoxylin", "(", "Mayer", "’s", ...
PMC4270159	To estimate original effect sizes, we determined approximate IC50 concentrations from the original survival curve images.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "estimate", "original", "effect", "sizes", ...
PMC11126803	We performed phenotypic validation through in vitro VM formation and invasion assays, experiments as well as clinical data showed that LncRNA-SERB and ERβ can significantly promote ccRCC VM formation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11348300	PF and DF of PpIX were acquired in a sequential way, with an effective frame rate of 10 fps, allowing “real-time” reconstruction of the normalized hypoxia image (i.e., DF/PF).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Incidence of thrombosis, adverse events and mortality were compared among the cohorts.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Incidence", "of", "thrombosis", ",", "adverse", "events", "and", "mortality...
PMC11725127	HEK293T cells stably expressing Flag-KRAS were co-transfected with an increasing dose of Myc-USP2.	[ { "tags": [ "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HEK293", "T", "cells", "stably", "expressing", "Flag-KRAS"...
PMC11531744	We could see from Figs. 4C and 4D that the death numbers increased and the survival time decreased as the risk score rose.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", ...
PMC11731161	This was particularly evident in the significantly elevated IC50 values observed in U266 and RPMI-8226 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O" ], "tokens": [ "This", "was", "particularly", "evident", "...
PMC11627398	Furthermore, Balamurugan et al. found that MTF-1 could promote the transcription of PIGF, an angiogenic gene .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "Balamurugan", "et", ...
PMC11400680	Similarly, as we can see in Figure 7B, our method also achieved high mAP50 scores for cells segmentation, showing majority of mAP50 scores reached up to 1 and the minimum value 0.5.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10818573	Clear bands were observed for the positive control, and no bands were observed for the negative and blank controls (Figure 2A), indicating that the primers and sample types are suitable for the RPA system.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10761571	Fig. 2XRD pattern of Fe3O4@Glu-Gingerol NPs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Fig.", "2XRD", "pattern", "of", "Fe3O4@Glu-Gingerol", "NPs", "." ] } ]
PMC2614415	On day one of treatment, cells were treated with or without 15 ng/mL paclitaxel (Sigma-Aldrich, St. Louis, MO) plus varying concentrations and combinations of VE-465 (Vertex Pharmaceuticals, Abingdon, United Kingdom), or with 50 μM z-vad (EMD Chemicals, San Diego, CA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11525028	15 μg total protein were loaded for SDS-PAGE.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "15", "μg", "total", "protein", "were", "loaded", "for", "SDS-PAGE", "." ] } ]
PMC10142392	The ability of multi-armed copolymers to load and encapsulate a large number of drugs compared to linear analogues has been demonstrated in several other studies that have addressed drug delivery applications (Table 1) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11531744	Risk curves showing the distribution of risk score. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Risk", "curves", "showing", "the", "distribution", "of", "risk", "score", ".", "(" ] } ]
PMC11545737	LPS can also be internalized into the cell where it activates the non-canonical inflammasome.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "LPS", "can", "also", "be", "internalized", "into", "the", "cell"...
PMC11759543	A study on endoplasmic reticulum (ER) stress-induced cell death found that persistent ER stress can lead to cell death through the caspase 8-apoptosis and necroptosis pathways .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11507371	To further examine the differential redox adaptation as a response to CAP in cancer and non-malignant cells at a molecular level, key players in the ROS sensing machinery were analysed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11777207	intraperitoneal.	[ { "tags": [ "O", "O" ], "tokens": [ "intraperitoneal", "." ] } ]
PMC11448304	The protein sample was then redissolved in 200 mM TEAB and ultrasonically dispersed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "protein", "sample", "was", "then", "redissolved", "in", "200", ...
PMC10656496	Cells were then treated for 72 h with Courmermycin-A1 (CA1), a Cdc45-MCM-GINS helicase inhibitor (CMGi) that helps prevent cell recovery after treatment, and then the whole cycle was repeated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11723210	Compared to traditional microscopes, the main advantage of LFOCM is that its imaging FOV can reach the size of the photosensitive surface of the image sensor, making it a promising high-throughput QPI technology suitable for high-throughput imaging of subcellular structures in biological samples, including cell biology, digital pathology, and drug screening.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9454178	The phosphorylated forms of AKT and ERK were all prominently downregulated by CDK7 or THZ1 knockdown (Fig. 7B, E).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "phosp...
PMC9532503	Glycan analysis was performed to study the heterogeneity of the test anti-CD20 antibody sample (P2-CRD-1508) compared to that of the control antibody sample (RS-03-25), in terms of glycosylation, which is a common post-translation modification in recombinant monoclonal antibodies expressed in mammalian cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Zanubrutinib achieved comparable PFS to ibrutinib (1.07 [0.59, 1.94]).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Zanubrutinib", "achieved", "comparable", "PFS", "to", "ibrutinib", "("...
PMC11607321	We designed MOSA tailored to the cancer cell lines multi-omic datasets, performed robust data augmentation, and provided model explanations for biomarker discovery (Fig. 1b, see Methods).Fig.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9622879	This trading function is run after the SS is run, and each home already knows the buying or selling action at each time slot of the day.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5810978	The IPEC-J2 cells treated with bacteria supernatants showed a drastic decrease in HuNoV RNA levels (< 0.1 fold) for unknown reasons.	[ { "tags": [ "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10507284	According to the operating manual, a proper amount of transfected SW982 cells were collected, and the supernatant was discarded by centrifugation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC6617630	BET pharmacological inhibitors such as I-BET151 (GSK1210151A) which was reported as a novel BET bromodomain inhibitor that had proved its efficacy in mixed-lineage leukemia (MLL) cell lines at inducing apoptosis and cell cycle arrest .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9812014	These inhibitors are reported to be fusion protein inhibitors of RSV and target the entry and attachment of RSV to host cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "inh...
PMC11528603	A: HL60 cells treated with SA-EA (4.1 μg/ml) and 0.05% DMSO (control) for 96 hours.	[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", ":", ...
PMC11757230	Twenty-four 6-week-old male SCID/Beige mice were purchased from Jackson Laboratory Japan (Kanagawa, Japan), housed and handled aseptically in autoclaved isolator cages with temperature and light control, and provided ad libitum access to sterile water and food.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11766350	The resulting colonies were screened for the number of shRNA cassette inserts.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "resulting", "colonies", "were", "screened", "for", "the", "number", "of",...
PMC9429973	Oral treatment gives a really good compliance, in frail and unfit patients, and response, when present, is always really fast (median time to response: 2 months (r.1-6)), median OS from diagnosis was 94 months (range 21-234), median OS from start of pomalidomide was 9 months (range 1-25).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7351993	The hydrodynamic focuser serves to avoid cells from flowing near the microchannel walls where the effect of acoustic focusing is weak.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "hydrodynamic", ...
PMC11575040	In this study, we used NGS to identify metformin-regulated-miRNA/lncRNAs in melanoma cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "this", "study", ",", "we", "used", "NGS", "to", "identify", ...
PMC9429973	This real-world population-based study provides useful information on patients usually excluded from clinical trials (those with advanced age, comorbidities, other malignancies).Older patients showed the greatest improvement over time.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5261804	Pathway entities that could not be mapped to HUGO were excised from the pathway model.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Pathway", "entities", "that", "could", "not", "be", "mapped...
PMC11188874	A drawback of in vitro assays is the failure to capture the inherent complexity of organ systems.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "drawback", "of", "in", "vitro", "assay...
PMC7342409	ERK and KIT expression and regulation levels were detected by Western blotting.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ERK", "and", "KIT", "expression", "and", "regulation", "levels", "were", "detect...
PMC10547921	Figure 8Design and SAR analysis of EG5 inhibitors. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Figure", "8Design", "and", "SAR", "analysis", "of", "EG5", "inhibitors", ".", "(" ] } ]
PMC11658074	j, k The protein expression of Col1, MMP9, and p21 in the two groups. *	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "j", ",", "k", "The", "protein", ...
PMC9429973	Through this prospective cohort study, we examined the development and durability of anti-receptor binding domain (RBD) IgG after two doses of BNT162b2 in 179 patients with either multiple myeloma (MM) or Chronic Lymphatic B-cell Leukemia (B-CLL) six months after vaccination and compared to immunocompetent controls.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11474209	Aptamer-based fluorescent sensorReal water sample138 pMA fluorescence sensor for MC-LR selective identification was built using epoxy, SWNT immobilizers, DAP−10 aptamer, and unmodified Apt sensing ligand.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11612315	However, previous studies have not investigated GLP-1 analogs and exendin 9–39 for pain transmission at peripheral sites, especially in small-sized nociceptive DRG neurons, where the TRPV1 channel is crucial in chronic pain-induced mechanical allodynia and thermal hyperalgesia.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9596868

Using the StepOne™ Real-Time PCR System (ThermoFisher Scientific) samples were incubated for 30 min at 30°C followed by initial activation at 95°C for 10 min and amplification by 40 PCR cycles with 15 s at 95°C and 60 s at 60°C conditions.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11599565

The paraneoplastic protein MA1 (PNMA1) (K & O) is also detectable in SKOV3 ovarian carcinoma cells.

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PMC9429973

These individuals often have unanswered questions about living with or treating multiple myeloma.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "individuals", "often", "have", "unanswered", "questions", "about", ...

PMC8316344

Next, we investigated how TRIB2 reduces labile iron in liver cancer cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Next", ",", "we", "investigated", "how", "TRIB2", "reduces", "labile", ...

PMC10978090

HIPA + PF4 remained negative until D22.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HIPA", "+", "PF4", "remained", "negative", "until", "D22", "." ] } ]

PMC11348300

Concurrently, there is minimal change in PpIX fluorescence intensity in the blood during this period, suggesting negligible presence of PpIX in the blood.

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PMC11609529

Therefore, we successfully detected the endogenous YM fusion transcript and protein in ES-2 ovarian cancer cells.

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PMC10810426

Shown is the average ± SD.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Shown", "is", "the", "average", "±", "SD", "." ] } ]

PMC9688728

After processing the initial data under the indicated conditions, in all tiles, the hits with the maximum area difference between days of cultivation (F-ratio > 5) were accepted for further analysis.

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PMC11266100

The gating strategy illustrates transfected cells analysis.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "gating", "strategy", "illustrates", "transfected", "cells", "analysis", "." ] } ]

PMC10317042

E, Genome browser screenshot of the epigenome maps at EWSR1.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "E", ",", "Genome", "browser", "screenshot", "of", "the", "epigenome", "maps", "at", ...

PMC11763111

In order to evaluate the protective impact of LLT1 overexpression, CAR-T cells and purified CD3CD56 primary NK cells were co-cultured for 24 h at different E : T ratios (Fig. 5C).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC6160470

Inlet shows representative flow cytometry histograms of A2780/Adr cell line treated with 10 µM concentration of compounds as indicated.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Inlet", "shows", "representative", ...

PMC11411004

Treatment with 2 μM I-4 was most effective in increasing monoclonal antibody production.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Treatment", "with", "2", "μM", "I-4", "was", "most", "effective", "in...

PMC11422497

The cumulative evidence indicates that miR-494-3p serves as one of the functional target miRNAs of circ_SMA4, manifesting a miRNA sponge effect.

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PMC10092581

As previously reported, LoVo OXP cells (derived from LoVo cells grown in the presence of increased concentration of oxaliplatin) were about 13‐fold more resistant to oxaliplatin than parental cells.

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PMC11789597

Moreover, cytokines regulated by CAV1 were examined using a cytokine array (Figure 2F).

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PMC11658074

The specific reagents, instruments, and operations used are listed in the supplementary information.

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PMC11518702

In addition, in HGAL isoform B, its polybasic cluster is disrupted by Ser10 replacing Arg10 (with Arg10 shifting to Arg12).

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PMC11092382

It has been shown that in a mouse model of isoproterenol (ISO)-induced kidney injury, sophocarpine could alleviate kidney injury by reducing the serum levels of serum creatinine (SCr) and blood urea nitrogen (BUN), inhibiting inflammatory cytokine release, preventing fibrosis, and reducing apoptosis and oxidative stress.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9219615

Pyrazoles are 5-membered heterocycles that contain three carbon atoms and two adjacent nitrogen (Figure 1).

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PMC11473750

Differences in cell growth were compared to Control siRNA transfected cells. ***

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PMC11684297

Guidelines in drug delivery literature commonly classify nanoparticle dispersions based on their zeta potential values as follows: ±0–10 mV as highly unstable, ± 10–20 mV as relatively stable, ± 20–30 mV as moderately stable, and > ± 30 mV as highly stable .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Image: Summary/Conclusion: To our knowledge, this is the first report of EV protein content from a real-world MGUS and MM patient cohort followed for more than 2 years.

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PMC11783017

Schematic illustration showing the enhanced immune infiltration from cold tumor to hot tumor. (

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PMC9429973

However, OS and EFS, better than adult ALL treated by adult protocol (OS= 14%, EFS=14% in previous local study) but less than describe in the literature.

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PMC11190538

Phosphatidylcholine's hydrophobic chains combine in an aqueous environment to form a hydrophobic bilayer.

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PMC8557138

Yan et al. used HeLa cell-laden silk fibroin hydrogel implants in CAM models to show the induction of apoptosis mediated by conformational changes in the 3D structure of the hydrogel.

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PMC11569208

In both scenarios, further investigation is warranted to cement the role of each respective PP in the IFN pathway and further our understanding of how the phosphatome interacts with the natural anti-viral response.

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PMC9841531

Dilution series of compounds 17–32 between 1 nM and 1 μM were prepared in DPBS (Cell Clone, Genetix Biotech Asia, New Delhi India), and 10 μL of each concentration was pipetted into a colorless flat-bottom 96-well microplate (SPL Life Sciences, Gyeonggi-do, Republic of Korea).

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PMC11543853

A selected virion is indicated by a green arrowhead.

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PMC11757230

As in these studies, most reports of the anti-tumorigenic effects of MSCs involve immortalized LL cell lines, while studies reporting pro-tumorigenic effects have typically used primary LL cells derived from patients .

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PMC11777207

We tested whether blocking the ability of PD-L1 to bind to PD-1 on the surface of the DCs using αPD-1 pembrolizumab would impede DC migration (Fig. 1B).

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PMC8357004

Total RNA extraction kit (TRIZOL reagent) and real-time polymerase chain reaction (RT-PCR) kits (qPCR MasterMix Plus for SYBR Green I dNTP) were obtained from Applied Biosystems Inc. (Foster, CA, USA).

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PMC9844987

We find that expression variability can be largely explained by a promoter’s DNA sequence and its binding sites for specific transcription factors.

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PMC11627060

Our experiment investigated a NP-based drug delivery system.

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PMC8382973

Before investigating whether the immune response after 2P23 gel rectovaginal application correlates with changes in the mucosal microbiome profile, we evaluated the bacterial composition similarities and differences in the rectal and vaginal compartments at baseline (Day 0 of 2P23 gel rectovaginal application).

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PMC11761919

Fig. 1Schematic diagram of in vivo experiment in chicken.

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PMC11371747

Values are calculated from the separate ratios of (IC50 antifolate + LV/IC50 antifolate).

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PMC11682525

In light of these considerations, the present study aimed to assess the impact of hypoxic preconditioning on cell survival and tolerance to oxidative stress in two distinct categories of human cells: nestin-expressing hair follicle stem cells (hHFSCs) and SH-SY5Y neuroblastoma cells.

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PMC9429973

Central tendency measures were plotted against histological and clinical MAGIC (Mount Sinai Acute GVHD International Consortium) scores related to GI-GVHD and a multivariate analysis was performed to exclude confounding factors.

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PMC9341513

The arrow shows the transcription start site.

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PMC11723947

We then tested the involvement of HP1γ in the susceptibility of allospecific Tconv to Treg-mediated suppression.

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PMC6901583

After incubation, imaging of tube formation by microscopy and quantification the branch number in the formed HUVEC tubes were performed.

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PMC9454178

Two researchers separately evaluated the staining level and divided the patients into high and low CDK7 expression groups (Fig. 1C).

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PMC10047551

A significant inverse correlation was observed between the methylation of cg19724470 and PD-L1 TPS (Figure 5B).

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PMC9429973

Regarding the patients diagnosed with SCD and MMS, MMS was diagnosed at 9 years old in one patient and at 10 years old in another.

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PMC9268620

One-way analysis of variance (ANOVA) was also used for multiple comparisons, where p < 0.05 was considered to be statistically significant.

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PMC10958426

We set the number of tumor subclones (k) from 6 to 2 and chose the largest k as the number of tumor subclones when each tumor subclone has unique CNV pattern in each patient.

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PMC11092418

Brain cancer is one of the deadliest and most lethal types of human cancers.

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PMC11574271

Western blot analysis was employed to validate the expression of MMP12.

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PMC10631132

A-L Representative images of 3 replicates display ALP-stained colonies and cell-forming complexes of a PBMC-derived cell line (A-F) and a fibroblast-derived cell line (G-L), showing high expression of ALP while expanding (A, B, G, H).

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PMC9712534

Original uncropped images are shown in Supplementary Fig. S4.

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PMC10669966

The tissues were counterstained with hematoxylin (Mayer’s, Cat.

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PMC4270159

To estimate original effect sizes, we determined approximate IC50 concentrations from the original survival curve images.

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PMC11126803

We performed phenotypic validation through in vitro VM formation and invasion assays, experiments as well as clinical data showed that LncRNA-SERB and ERβ can significantly promote ccRCC VM formation.

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PMC11348300

PF and DF of PpIX were acquired in a sequential way, with an effective frame rate of 10 fps, allowing “real-time” reconstruction of the normalized hypoxia image (i.e., DF/PF).

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PMC9429973

Incidence of thrombosis, adverse events and mortality were compared among the cohorts.

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PMC11725127

HEK293T cells stably expressing Flag-KRAS were co-transfected with an increasing dose of Myc-USP2.

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PMC11531744

We could see from Figs. 4C and 4D that the death numbers increased and the survival time decreased as the risk score rose.

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PMC11731161

This was particularly evident in the significantly elevated IC50 values observed in U266 and RPMI-8226 cells.

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PMC11627398

Furthermore, Balamurugan et al. found that MTF-1 could promote the transcription of PIGF, an angiogenic gene .

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PMC11400680

Similarly, as we can see in Figure 7B, our method also achieved high mAP50 scores for cells segmentation, showing majority of mAP50 scores reached up to 1 and the minimum value 0.5.

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PMC10818573

Clear bands were observed for the positive control, and no bands were observed for the negative and blank controls (Figure 2A), indicating that the primers and sample types are suitable for the RPA system.

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PMC10761571

Fig. 2XRD pattern of Fe3O4@Glu-Gingerol NPs.

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PMC2614415

On day one of treatment, cells were treated with or without 15 ng/mL paclitaxel (Sigma-Aldrich, St. Louis, MO) plus varying concentrations and combinations of VE-465 (Vertex Pharmaceuticals, Abingdon, United Kingdom), or with 50 μM z-vad (EMD Chemicals, San Diego, CA).

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PMC11525028

15 μg total protein were loaded for SDS-PAGE.

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PMC10142392

The ability of multi-armed copolymers to load and encapsulate a large number of drugs compared to linear analogues has been demonstrated in several other studies that have addressed drug delivery applications (Table 1) .

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PMC11531744

Risk curves showing the distribution of risk score. (

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PMC11545737

LPS can also be internalized into the cell where it activates the non-canonical inflammasome.

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PMC11759543

A study on endoplasmic reticulum (ER) stress-induced cell death found that persistent ER stress can lead to cell death through the caspase 8-apoptosis and necroptosis pathways .

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PMC11507371

To further examine the differential redox adaptation as a response to CAP in cancer and non-malignant cells at a molecular level, key players in the ROS sensing machinery were analysed.

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PMC11777207

intraperitoneal.

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PMC11448304

The protein sample was then redissolved in 200 mM TEAB and ultrasonically dispersed.

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PMC10656496

Cells were then treated for 72 h with Courmermycin-A1 (CA1), a Cdc45-MCM-GINS helicase inhibitor (CMGi) that helps prevent cell recovery after treatment, and then the whole cycle was repeated.

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PMC11723210

Compared to traditional microscopes, the main advantage of LFOCM is that its imaging FOV can reach the size of the photosensitive surface of the image sensor, making it a promising high-throughput QPI technology suitable for high-throughput imaging of subcellular structures in biological samples, including cell biology, digital pathology, and drug screening.

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PMC9454178

The phosphorylated forms of AKT and ERK were all prominently downregulated by CDK7 or THZ1 knockdown (Fig. 7B, E).

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PMC9532503

Glycan analysis was performed to study the heterogeneity of the test anti-CD20 antibody sample (P2-CRD-1508) compared to that of the control antibody sample (RS-03-25), in terms of glycosylation, which is a common post-translation modification in recombinant monoclonal antibodies expressed in mammalian cell lines.

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PMC9429973

Zanubrutinib achieved comparable PFS to ibrutinib (1.07 [0.59, 1.94]).

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PMC11607321

We designed MOSA tailored to the cancer cell lines multi-omic datasets, performed robust data augmentation, and provided model explanations for biomarker discovery (Fig. 1b, see Methods).Fig.

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PMC9622879

This trading function is run after the SS is run, and each home already knows the buying or selling action at each time slot of the day.

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PMC5810978

The IPEC-J2 cells treated with bacteria supernatants showed a drastic decrease in HuNoV RNA levels (< 0.1 fold) for unknown reasons.

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PMC10507284

According to the operating manual, a proper amount of transfected SW982 cells were collected, and the supernatant was discarded by centrifugation.

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PMC6617630

BET pharmacological inhibitors such as I-BET151 (GSK1210151A) which was reported as a novel BET bromodomain inhibitor that had proved its efficacy in mixed-lineage leukemia (MLL) cell lines at inducing apoptosis and cell cycle arrest .

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PMC9812014

These inhibitors are reported to be fusion protein inhibitors of RSV and target the entry and attachment of RSV to host cells .

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PMC11528603

A: HL60 cells treated with SA-EA (4.1 μg/ml) and 0.05% DMSO (control) for 96 hours.

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PMC11757230

Twenty-four 6-week-old male SCID/Beige mice were purchased from Jackson Laboratory Japan (Kanagawa, Japan), housed and handled aseptically in autoclaved isolator cages with temperature and light control, and provided ad libitum access to sterile water and food.

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PMC11766350

The resulting colonies were screened for the number of shRNA cassette inserts.

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PMC9429973

Oral treatment gives a really good compliance, in frail and unfit patients, and response, when present, is always really fast (median time to response: 2 months (r.1-6)), median OS from diagnosis was 94 months (range 21-234), median OS from start of pomalidomide was 9 months (range 1-25).

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PMC7351993

The hydrodynamic focuser serves to avoid cells from flowing near the microchannel walls where the effect of acoustic focusing is weak.

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PMC11575040

In this study, we used NGS to identify metformin-regulated-miRNA/lncRNAs in melanoma cells.

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PMC9429973

This real-world population-based study provides useful information on patients usually excluded from clinical trials (those with advanced age, comorbidities, other malignancies).Older patients showed the greatest improvement over time.

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PMC5261804

Pathway entities that could not be mapped to HUGO were excised from the pathway model.

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PMC11188874

A drawback of in vitro assays is the failure to capture the inherent complexity of organ systems.

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PMC7342409

ERK and KIT expression and regulation levels were detected by Western blotting.

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PMC10547921

Figure 8Design and SAR analysis of EG5 inhibitors. (

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PMC11658074

j, k The protein expression of Col1, MMP9, and p21 in the two groups. *

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PMC9429973

Through this prospective cohort study, we examined the development and durability of anti-receptor binding domain (RBD) IgG after two doses of BNT162b2 in 179 patients with either multiple myeloma (MM) or Chronic Lymphatic B-cell Leukemia (B-CLL) six months after vaccination and compared to immunocompetent controls.

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PMC11474209

Aptamer-based fluorescent sensorReal water sample138 pMA fluorescence sensor for MC-LR selective identification was built using epoxy, SWNT immobilizers, DAP−10 aptamer, and unmodified Apt sensing ligand.

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PMC11612315

However, previous studies have not investigated GLP-1 analogs and exendin 9–39 for pain transmission at peripheral sites, especially in small-sized nociceptive DRG neurons, where the TRPV1 channel is crucial in chronic pain-induced mechanical allodynia and thermal hyperalgesia.

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