OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC8584319	As cancer cells actively produce anti-apoptotic proteins rather than pro-apoptotic proteins , we attempted to understand the effect of AZD8055 on translation in cancer cells using the hepatocellular carcinoma cell line HepG2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11795610	Compared with the high Ca group, fluo-4 fluorescence intensities were significantly increased by GSK1016790A and myricetin, and further enhanced by a combined treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11676674	CellProfiler (version 4.2.6) a freely available modular image analysis software tool capable of handling hundreds of thousands of images and represents a flexible platform for the sharing, testing, and development of new methods by image analysis experts.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11063646	Based on all physiochemical and statistical evaluation studies it was concluded that ANG 12, the optimised nanoemulgel is best suitable formula that could prove its therapeutic significance for cancer therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11638288	In summary, NKp46 controls tumor growth by promoting antibody-dependent cell-mediated cytotoxicity and reducing the expression of NKp46 ligands and the secretion of IFN-γ through immune editing.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11435360	An ideal model of BC would allow for tumors to (i) be of urothelial origin; (ii) grow within the bladder to interact with other layers of the bladder wall and receive direct exposure to intravesical therapies; and (iii) be easy to develop within a reasonable timeframe, thus yielding reproducible and reliable results .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11095939	Gates were set over the G0/G1, S, and G2/M peaks, and then the percentages of cells in different cell cycle phases were calculated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11665584	Our previous study identified the human orthologs SPRR2A and DSC2 as highly upregulated genes in human buccal mucosa compared with skin at baseline and during wound healing (4).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11718031	For instance, proper protein glycosylation, crucial for mAb stability, safety, and efficacy, heavily relies on cell culture conditions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", ...
PMC11335267	Values (in grams force) were recorded and the average of three trials spaced at 2 min intervals was used for analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Values"...
PMC11144200	Because Nb36 has been generated with a His-tag, a fluorescent signal may be produced by using an anti-His-tag monoclonal antibody.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Because", "Nb36", ...
PMC10818062	Cancer cells are known to adapt their lipid metabolism for growth.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cancer", "cells", "are", "known", "to", "adapt", "their", "lipid", "metabolism", "for...
PMC11699465	5800 MALDI-TOF/TOF (AB Sciex, USA) was used for mass spectrometer (MS) data analyses.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "5800", "MALDI-TOF/TOF", "(", "AB", "Sc...
PMC9429973	Venous thromboembolism accounted for the majority of the thrombotic events (91% and 100% in the AT3/cryoprecipitate vs AT3/cryoprecipitate + prophylactic anticoagulation, respectively).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10079526	This can be explained by STUbL (SUMO targeted ubiquitin ligase) RNF4 dependent proteolysis of DPCs as described previously .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "can", "be", "e...
PMC9429973	Recent literature showed CT myocardial perfusion imaging can well evaluate the effect of myocardial amyloidosis on myocardial function.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Recent", "literature", "showed", "CT", ...
PMC3734024	Taken together these findings elucidate the relationship of FasL B cells and IL-10-producing B cells and demonstrate that IL-5 can induce or enhance both killer B cell activity and IL-10 secretion in B cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7452526	The inset is a photograph for changing colour within different time (10, 30, and 120 min).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "inset", "is", "...
PMC11412721	p53-FL and p53-AS were expressed at similar levels and both transactivated p21, whereas the DNA-binding mutant p53 was expressed at higher amounts but failed to transactivate p21, as expected.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9672323	Additionally, dexamethasone limited the cell cycle progression by increasing the fraction of PBMCs in G0/G1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", "dexamethasone", "limited", "the", ...
PMC11733919	As TIS may be more heterogeneous when activated in cancer cells, two models of TIS (doxorubicin and etoposide treatments) and two markers of senescence (SA-β-gal activity, p21 levels) were considered in senescent skin cancer cells (Figure 1b).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	A. M. Haidary, S. Noor Haematopathology and Blood Bank, French Medical Institute for Mothers and Children; Haemato-oncology, Jumhoriat Hospital, Kabul, Afghanistan Background: Current guidelines for chronic myeloid leukemia (CML) management include utilization of both conventional cytogenetics as well as advance molecular analysis at diagnosis and while monitoring the therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11544122	We observed 10-fold greater high-affinity binding between SNX9 and the membrane-proximal phospho-peptide relative to an unphosphorylated peptide (Fig. 6d and Supplementary Table 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11656048	The samples were observed under a confocal microscope (Nikon, Japan).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "samples", "were", "observed", "under", "a", "confocal", "microscope"...
PMC6034753	Meq was able to pull out Apoptin from the lysate in all cases showing the CtBP motif and leucine zipper were not crucial for the interaction. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10999934	During an in vitro study, it was observed that the IC50 of cisplatin decreased in A2780 and SKOV3 human ovarian carcinoma cell lines when FBXO2 was silenced, as opposed to the control group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "...
PMC11394730	Cancer cells have a unique phenomenon that helps stabilize them and improve their chances of growth and survival; they are capable of forming new blood vessels by exciting vessels, which is known as angiogenesis or neoangiogenesis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11544122	Bioluminescence resonance energy transfer (BRET) was used to measure interactions between SNX9 and CXCR4 or the plasma membrane.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Bioluminescence", "resonance", ...
PMC10587429	Recently, humanized mouse models have been developed for a variety of human cancers, including breast, colorectal, pancreatic, lung, adrenocortical, melanoma and hematological malignancies (7–12).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11473750	High RNF121 mRNA expression associated with poor prognosis in human neuroblastoma tissues and another MYC-driven malignancy, laryngeal cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "High", "RNF121", "mRNA", "express...
PMC11787651	They are closely associated with a host of enzymes that modulate a variety of biological processes, including chromatin condensation, transcription, and DNA repair (1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10631132	Image acquisition was performed using a Leica DMI6000 inverted microscope in phase-contrast mode, and tiled full well images were analyzed for cell size and multinucleation using ImageJ. Immunocytochemistry (ICC) was performed after EB or MB induction in order to assess mesodermal differentiation and after termination of RANKL treatment in order to assess OCs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8633974	Figure 4Exonic Disruption and HIV-1 Replicative Fitness. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Figure", "4Exonic", "Disruption", "and", "HIV-1", "Replicative", "Fitness", ".", "(" ] } ]
PMC11285179	Anti-angiogenic therapy inhibits abnormal blood vessel formation, fostering vascular normalization through mechanisms like reducing vessel density, remodeling the extracellular matrix, regulating inflammation, balancing growth factors, and modulating the immune system.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Summary/Conclusion: The negative longitudinal association between hospital admission for VOC and HRQoL in pediatric patients with SCD gets worse and persists up to 12 months.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973	This decision-analytic model, though not absolute, provided relevant and robust results to help inform clinical decision making.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "decision-analytic", "model", ...
PMC10887351	In humans or rats , pregnancy might influence β-AR expression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "humans", "or", "rats", ",", "pregnancy", "might", "influence", "β-AR", "expression", ...
PMC11742290	Interestingly, Kim et.	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "Interestingly", ",", "Kim", "et", "." ] } ]
PMC10237474	This is likely because protein 11 from GnTI is more homogeneous than that from CHO-K1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O" ], "tokens": [ "This", "is", "likely", "because", "protein", "11", ...
PMC11589157	Heatmap of Hi-C interaction density for Hap2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Heatmap", "of", "Hi-C", "interaction", "density", "for", "Hap2", "." ] } ]
PMC9388315	Overexpression of ErbB2 was seen in bladder cancer and is associated with poor prognosis [40–42].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Overexpression", "of", "ErbB2", "was", "seen", ...
PMC9429973	There is currently a lack of consensus around therapy beyond steroids .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "There", "is", "currently", "a", "lack", "of", "consensus", "around", "therapy", "beyo...
PMC11506670	All experiments were conducted three times, each in triplicate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "experiments", "were", "conducted", "three", "times", ",", "each", "in", "triplicate", ...
PMC9429973	CYT-338 mediated fratricide was evaluated in purified PB-NK’s.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CYT-338", "mediated", "fratricide", "was", "evaluated", "in", "purified", "PB-NK", "’s", "." ] } ]
PMC11075223	Actein remarkably repressed HIV replication in H9 lymphocytes with EC50 of 0.375 μg/mL and the treatment index value of 144 .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Actein", "remarkably", ...
PMC10747139	However, it differs from cisplatin, as it revealed no cross-resistance against cisplatin-resistant ovarian carcinoma cells (A2780cis); this is indicative of a distinctive mode of anticancer action and has also been reported to trigger p53-dependent cell-cycle arrest .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", ...
PMC11295144	The β3 subunit was myc-tagged.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "β3", "subunit", "was", "myc-tagged", "." ] } ]
PMC9841531	The solute carrier (SLC) monocarboxylate transporter 1 (MCT1; SLC16A1) represents a promising target for the treatment of cancer; however, the MCT1 modulator landscape is underexplored with only roughly 100 reported compounds.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11665584	These neutrophils were highly concentrated around hair follicles and had distinct cell-cell communication with various subpopulations in the PITX1 skin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "neutrophils", "were...
PMC10380508	In a recent commentary by Turajlic et al. focusing on the molecular pathological characteristics, patient outcomes, and potential treatment strategies of kidney cancer, it was proposed that KIRC tumors with low intra-tumoral heterogeneity (ITH) and a low fraction of the genome affected by somatic copy-number alterations (SCNA) often exhibit reduced metastatic potential and more favorable overall prognosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11750712	Rituximab was administered (once per week) on day 78 and the event resolved on day 93.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Rituximab", "was", "administered", "(", ...
PMC11699465	We proposed to find the functional localization of TMEM199 by analyzing its interacting proteins.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "proposed", "to", "find", "the", "functional", "localization", ...
PMC11757230	Although the role of MSCs in hematologic malignancies such as lymphomas and leukemias is less completely understood than in solid tumors, human MSCs also appear to have dual effects on lymphoma/leukemia (LL) cells, either supporting or inhibiting their development by differentially affecting apoptosis and the cell cycle .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11036064	A yellow sterile pipette tip was then used to scrape the cellular monolayer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "yellow", "sterile", "pipette", "tip", "was", "then", "used", "to...
PMC10734950	Each data point within the experiment was derived from a minimum of three separate measurements.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Each", "data", "point", "within", "the", "experiment", "was...
PMC11026382	Additionally, the relative abundance of 10-formyl-THF was previously measured by liquid chromatography mass spectrometry for all ten DHFR/TYMS combinations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", "the", ...
PMC11342785	In contrast, the weaker droplet-forming LAF-1 hubs showed significantly lower bundling rates and lower end-point bundling (Figs. 6D and S8).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", ...
PMC11525028	Both inhibitors effectively reduced ac4C modification levels of mRNA and decreased ATF4 and ASNS expression, leading to diminished Asn levels.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Both", "inhibitors", ...
PMC11767725	Systemic lipid abnormalities, including elevated total cholesterol, LDL, and reduced HDL, are also common in SD patients, with studies linking these dyslipidemias to increased SD severity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11687663	Evaluating the compounds’ potential application and efficiency in diverse biomedical and pharmaceutical contexts is made possible by these thorough examinations, which also greatly add to our understanding of the compounds’ behaviour at the molecular level.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11078693	Centrifuge the cells at 200 g and 4°C for 10 min.i.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Centrifuge", "the", "cells", "at", "200", "g", "and", "4", "°", ...
PMC11627060	The results were compared with previous FTIR studies of protein NPs .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "results", "were", "compared", "with", "previous", "FTIR", "studies", "of", "pr...
PMC11515150	Nevertheless, NK-92 cells require irradiation prior to clinical application resulting in the short lifespan in vivo.	[ { "tags": [ "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Nevertheless", ",", "NK-92", "cells", "r...
PMC11519788	VEZF1/SPOP/STAT3/CCL2/ IL-6 axis was determined by luciferase reporter, ChIP, RNA-seq, co-IP, in vitro ubiquitination, RT-qPCR array and ELISA analyses.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11359735	Lanes 7 to 9 were subjected to Western blotting and were used to estimate the position of CSP on the blot.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Lanes", "7", "to"...
PMC10809689	Then, cells were incubated in a 37 °C incubator for 3–4 h. After the incubation time, 100 µL of detergent solution was added to each well to dissolve the ferromazan crystals.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9325715	Our investigation has revealed that both iron forms, i.e. complexed with bLTF and iron citrate, at the concentration of up to 0.5 mM did not decrease the viability of the Caco-2 and L929 lines in MTT test (Fig. 6).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11634027	Ds staining in clones of homozygous ds cells was even weaker compared to neighboring heterozygous cells, whereas staining in clones of homozygous ds cells was comparable to that of neighboring heterozygous cells (Fig. S5B,C); these observations are consistent with our analysis of V5 staining.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11629192	After the second dose of OFA, liver enzyme ALT increased to 136 U/L and normalized within two weeks following treatment with oral hepatoprotective agent.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973	Results: Forty-five RRMM patients were enrolled, 36 of whom achieved minor response or better after 3 cycles of VRd (n=6) or KRd (n=30) and received IRd, and followed up for at least 12 months after the last patient startedinjectable PI-based therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9436459	The distribution of non-classic MDAAs in mulberry plants is limited, which were only found in the following three Morus plants, M. alba, M. lhou, and M. mongolica.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11757230	After the incubation period, a Cell Counting Kit-8 reagent (Dojindo, Kumamoto, Japan) was added to each well and incubated for an additional 2 h. The number of viable cells at each time point was measured by the optical density (OD) at 450 nm using a Synergy HT Microplate Reader (BioTek, Winooski, VT, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4443654	For each cell type we identified 1-Mb regions whose compartment state was altered relative to the other two.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "each", "cell", "type", "we", ...
PMC9429973	Methods: We included patients with hemato-oncological diseases assisted at Hospital de Clínicas and Hospital Maciel from Montevideo Uruguay, who were diagnosed with COVID-19 between march 2020 to February 2022.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11487720	Cells were washed three times with 1X PBS and then stained for 1 h with fluorescent secondary antibodies, conjugated with red fluorescent rhodamine, Texas red, or Alexa 555 (Molecular Probes/Invitrogen, Eugene, OR, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11394227	In conclusion, the co-overexpression of HsQSOX1b and survivin improved the protein synthesis in CHO-PAb-QS cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "In", "conclusion", ",", "the", "co-overexpression",...
PMC10213179	After incubation the supernatant was discarded and the beads were washed three times (5 min each wash) with lysis buffer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "inc...
PMC9429973	Results: We detected a number of aberrations that were already present at TP1, including del13q, del11q, mutations in NOTCH1, RPS15, ZMYM3, and minor mutations in TP53 and ATM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11679892	However, these approaches often come with significant toxicity, particularly in young patients, and are limited in their efficacy for high-risk cases.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9693627	The reaction was started by adding 2–10 × 10 cells, which were frozen/thawed two or three times in isotonic medium before using.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC10204952	Adipocyte-conditioned cell culture media AD-CM and CAA-CM can reduce nucleic alteration/apoptosis caused by high concentrations of S1P in TNBC cells, and CAA-CM is more potent than AD-CM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC3931643	Eukaryotic initiation factor 4E (eIF4E), which together with eukaryotic initiation factor 4G (eIF4G) and eukaryotic initiation factor 4A (eIF4A) form the cap-binding complex, is frequently overexpressed in human cancer and can cooperate with the Myc oncogene in an experimental lymphoma model .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	During the previous decade, several studies explored the role of FDG-PET/CT for detecting nodal and extranodal disease, with only one large study comparing both techniques.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11779876	Since oligoclonality for TRBC1 and TRBC2 would represent a major obstacle to achieve long term remissions with TRBC1 or TRBC2 directed CAR T cell therapy, we set out to analyze T cell receptor single cell sequencing data of CD3+ sorted T cells from twelve distinct T cell lymphoma cases for TRBC expression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4443654	However, other novel feature peaks of interest emerge across cell types, such as peaks of H4K20me1, a modification previously implicated in chromatin compaction .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11297139	Following commercially available fluorescent-labeled secondary antibodies were used: Alexa Fluor 488 donkey anti-rabbit IgG (A21206) and Alexa Fluor 594 donkey anti-mouse IgG (A21203) (Invitrogen).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10203589	Moreover, the established multivariate Cox proportional hazard regression model showed that overexpression of FGF18 was significantly associated with longer survival in AEG patients (45).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11782780	The study was approved by the 2021 Anhui University Natural Science research project (No. KJ2021A1271).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "study", "was", "approved", "by", "th...
PMC11564322	Our data revealed that VGVAPG and VVGPGA peptides affected the AKT and ERK 1/2 kinase protein expression in a similar way in all the tested leukemia cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11726848	This repair can be executed by different pathways of DNA double-strand break repair, e.g., the pathway based on homologous recombination, non-homologous end joining, and alternative end joining .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11730000	Consequently, secondary malignant tumors may arise during or after chemotherapy, distinguishing them from primary tumors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Consequently", ",", "secondary", "malignant", "tu...
PMC10605143	These results suggest that in cells with certain mesenchymal features (such as MCF12A), down-regulation of HSF1 can result in adopting epithelial morphology (observed in MCF10A cells).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Relapse after ATO/RA based therapy remains very challenging, and novel drug schemes to overcome resistance are urgently needed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Relapse", "after", "ATO/RA", "bas...
PMC11127909	The membranes were then washed three times with TBST before incubation with a secondary antibody (1:5000; CST; #7074 and #7076) at room temperature for 2 h. A Bio-Rad ECL detection system was used to examine the signals, and ImageJ (version 1.8.0) was used to analyze the data.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11790599	Cosimo Commisso found that cancers driven by oncogenic RAS utilize heightened macropinocytosis to augment their nutrient supply and maintain proliferation (Commisso et al., 2013).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8414691	Fig. 4Abnormal microtubules re-polymerization in SRCAP depleted HeLa cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "Fig.", "4Abnormal", "microtubules", "re-polymerization", "in", "SRCAP", "depleted", "HeLa", "cells", ...
PMC11055510	This study has shortcomings.	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "This", "study", "has", "shortcomings", "." ] } ]
PMC11172027	With the highest incubation time of 72 h, the IC50% could already be achieved with the use of 125 µg/mL NASeLM (204.0 ± 41.0% vs. 387.5 ± 37.3%) with a significance of p < 0.01 (n = 3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4659567	for RuCl3C17H19N2: C, 44.51; H, 4.18; N, 6.11; found: C, 44.32; H, 4.19; N, 5.95%.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11643491	The greater capability of aggressive and deformable cancer cells to preferentially uptake particles with a high AR, and therefore selectively be eradicated, highlights the potential of ellipsoidal particles to serve as candidates for targeted drug delivery in various biomedical applications.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8584319

As cancer cells actively produce anti-apoptotic proteins rather than pro-apoptotic proteins , we attempted to understand the effect of AZD8055 on translation in cancer cells using the hepatocellular carcinoma cell line HepG2.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11795610

Compared with the high Ca group, fluo-4 fluorescence intensities were significantly increased by GSK1016790A and myricetin, and further enhanced by a combined treatment.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC11676674

CellProfiler (version 4.2.6) a freely available modular image analysis software tool capable of handling hundreds of thousands of images and represents a flexible platform for the sharing, testing, and development of new methods by image analysis experts.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11063646

Based on all physiochemical and statistical evaluation studies it was concluded that ANG 12, the optimised nanoemulgel is best suitable formula that could prove its therapeutic significance for cancer therapy.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11638288

In summary, NKp46 controls tumor growth by promoting antibody-dependent cell-mediated cytotoxicity and reducing the expression of NKp46 ligands and the secretion of IFN-γ through immune editing.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11435360

An ideal model of BC would allow for tumors to (i) be of urothelial origin; (ii) grow within the bladder to interact with other layers of the bladder wall and receive direct exposure to intravesical therapies; and (iii) be easy to develop within a reasonable timeframe, thus yielding reproducible and reliable results .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11095939

Gates were set over the G0/G1, S, and G2/M peaks, and then the percentages of cells in different cell cycle phases were calculated.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC11665584

Our previous study identified the human orthologs SPRR2A and DSC2 as highly upregulated genes in human buccal mucosa compared with skin at baseline and during wound healing (4).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11718031

For instance, proper protein glycosylation, crucial for mAb stability, safety, and efficacy, heavily relies on cell culture conditions.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", ...

PMC11335267

Values (in grams force) were recorded and the average of three trials spaced at 2 min intervals was used for analysis.

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PMC11144200

Because Nb36 has been generated with a His-tag, a fluorescent signal may be produced by using an anti-His-tag monoclonal antibody.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Because", "Nb36", ...

PMC10818062

Cancer cells are known to adapt their lipid metabolism for growth.

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PMC11699465

5800 MALDI-TOF/TOF (AB Sciex, USA) was used for mass spectrometer (MS) data analyses.

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PMC9429973

Venous thromboembolism accounted for the majority of the thrombotic events (91% and 100% in the AT3/cryoprecipitate vs AT3/cryoprecipitate + prophylactic anticoagulation, respectively).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10079526

This can be explained by STUbL (SUMO targeted ubiquitin ligase) RNF4 dependent proteolysis of DPCs as described previously .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "can", "be", "e...

PMC9429973

Recent literature showed CT myocardial perfusion imaging can well evaluate the effect of myocardial amyloidosis on myocardial function.

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PMC3734024

Taken together these findings elucidate the relationship of FasL B cells and IL-10-producing B cells and demonstrate that IL-5 can induce or enhance both killer B cell activity and IL-10 secretion in B cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC7452526

The inset is a photograph for changing colour within different time (10, 30, and 120 min).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "inset", "is", "...

PMC11412721

p53-FL and p53-AS were expressed at similar levels and both transactivated p21, whereas the DNA-binding mutant p53 was expressed at higher amounts but failed to transactivate p21, as expected.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9672323

Additionally, dexamethasone limited the cell cycle progression by increasing the fraction of PBMCs in G0/G1.

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PMC11733919

As TIS may be more heterogeneous when activated in cancer cells, two models of TIS (doxorubicin and etoposide treatments) and two markers of senescence (SA-β-gal activity, p21 levels) were considered in senescent skin cancer cells (Figure 1b).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

A. M. Haidary, S. Noor Haematopathology and Blood Bank, French Medical Institute for Mothers and Children; Haemato-oncology, Jumhoriat Hospital, Kabul, Afghanistan Background: Current guidelines for chronic myeloid leukemia (CML) management include utilization of both conventional cytogenetics as well as advance molecular analysis at diagnosis and while monitoring the therapy.

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PMC11544122

We observed 10-fold greater high-affinity binding between SNX9 and the membrane-proximal phospho-peptide relative to an unphosphorylated peptide (Fig. 6d and Supplementary Table 1).

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PMC11656048

The samples were observed under a confocal microscope (Nikon, Japan).

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PMC6034753

Meq was able to pull out Apoptin from the lysate in all cases showing the CtBP motif and leucine zipper were not crucial for the interaction. (

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PMC10999934

During an in vitro study, it was observed that the IC50 of cisplatin decreased in A2780 and SKOV3 human ovarian carcinoma cell lines when FBXO2 was silenced, as opposed to the control group.

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PMC11394730

Cancer cells have a unique phenomenon that helps stabilize them and improve their chances of growth and survival; they are capable of forming new blood vessels by exciting vessels, which is known as angiogenesis or neoangiogenesis.

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PMC11544122

Bioluminescence resonance energy transfer (BRET) was used to measure interactions between SNX9 and CXCR4 or the plasma membrane.

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PMC10587429

Recently, humanized mouse models have been developed for a variety of human cancers, including breast, colorectal, pancreatic, lung, adrenocortical, melanoma and hematological malignancies (7–12).

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PMC11473750

High RNF121 mRNA expression associated with poor prognosis in human neuroblastoma tissues and another MYC-driven malignancy, laryngeal cancer.

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PMC11787651

They are closely associated with a host of enzymes that modulate a variety of biological processes, including chromatin condensation, transcription, and DNA repair (1).

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PMC10631132

Image acquisition was performed using a Leica DMI6000 inverted microscope in phase-contrast mode, and tiled full well images were analyzed for cell size and multinucleation using ImageJ. Immunocytochemistry (ICC) was performed after EB or MB induction in order to assess mesodermal differentiation and after termination of RANKL treatment in order to assess OCs.

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PMC8633974

Figure 4Exonic Disruption and HIV-1 Replicative Fitness. (

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PMC11285179

Anti-angiogenic therapy inhibits abnormal blood vessel formation, fostering vascular normalization through mechanisms like reducing vessel density, remodeling the extracellular matrix, regulating inflammation, balancing growth factors, and modulating the immune system.

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PMC9429973

Summary/Conclusion: The negative longitudinal association between hospital admission for VOC and HRQoL in pediatric patients with SCD gets worse and persists up to 12 months.

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PMC9429973

This decision-analytic model, though not absolute, provided relevant and robust results to help inform clinical decision making.

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PMC10887351

In humans or rats , pregnancy might influence β-AR expression.

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PMC11742290

Interestingly, Kim et.

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PMC10237474

This is likely because protein 11 from GnTI is more homogeneous than that from CHO-K1.

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PMC11589157

Heatmap of Hi-C interaction density for Hap2.

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PMC9388315

Overexpression of ErbB2 was seen in bladder cancer and is associated with poor prognosis [40–42].

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PMC9429973

There is currently a lack of consensus around therapy beyond steroids .

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PMC11506670

All experiments were conducted three times, each in triplicate.

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PMC9429973

CYT-338 mediated fratricide was evaluated in purified PB-NK’s.

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PMC11075223

Actein remarkably repressed HIV replication in H9 lymphocytes with EC50 of 0.375 μg/mL and the treatment index value of 144 .

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PMC10747139

However, it differs from cisplatin, as it revealed no cross-resistance against cisplatin-resistant ovarian carcinoma cells (A2780cis); this is indicative of a distinctive mode of anticancer action and has also been reported to trigger p53-dependent cell-cycle arrest .

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PMC11295144

The β3 subunit was myc-tagged.

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PMC9841531

The solute carrier (SLC) monocarboxylate transporter 1 (MCT1; SLC16A1) represents a promising target for the treatment of cancer; however, the MCT1 modulator landscape is underexplored with only roughly 100 reported compounds.

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PMC11665584

These neutrophils were highly concentrated around hair follicles and had distinct cell-cell communication with various subpopulations in the PITX1 skin.

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PMC10380508

In a recent commentary by Turajlic et al. focusing on the molecular pathological characteristics, patient outcomes, and potential treatment strategies of kidney cancer, it was proposed that KIRC tumors with low intra-tumoral heterogeneity (ITH) and a low fraction of the genome affected by somatic copy-number alterations (SCNA) often exhibit reduced metastatic potential and more favorable overall prognosis.

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PMC11750712

Rituximab was administered (once per week) on day 78 and the event resolved on day 93.

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PMC11699465

We proposed to find the functional localization of TMEM199 by analyzing its interacting proteins.

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PMC11757230

Although the role of MSCs in hematologic malignancies such as lymphomas and leukemias is less completely understood than in solid tumors, human MSCs also appear to have dual effects on lymphoma/leukemia (LL) cells, either supporting or inhibiting their development by differentially affecting apoptosis and the cell cycle .

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PMC11036064

A yellow sterile pipette tip was then used to scrape the cellular monolayer.

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PMC10734950

Each data point within the experiment was derived from a minimum of three separate measurements.

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PMC11026382

Additionally, the relative abundance of 10-formyl-THF was previously measured by liquid chromatography mass spectrometry for all ten DHFR/TYMS combinations.

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PMC11342785

In contrast, the weaker droplet-forming LAF-1 hubs showed significantly lower bundling rates and lower end-point bundling (Figs. 6D and S8).

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PMC11525028

Both inhibitors effectively reduced ac4C modification levels of mRNA and decreased ATF4 and ASNS expression, leading to diminished Asn levels.

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PMC11767725

Systemic lipid abnormalities, including elevated total cholesterol, LDL, and reduced HDL, are also common in SD patients, with studies linking these dyslipidemias to increased SD severity.

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PMC11687663

Evaluating the compounds’ potential application and efficiency in diverse biomedical and pharmaceutical contexts is made possible by these thorough examinations, which also greatly add to our understanding of the compounds’ behaviour at the molecular level.

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PMC11078693

Centrifuge the cells at 200 g and 4°C for 10 min.i.

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PMC11627060

The results were compared with previous FTIR studies of protein NPs .

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PMC11515150

Nevertheless, NK-92 cells require irradiation prior to clinical application resulting in the short lifespan in vivo.

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PMC11519788

VEZF1/SPOP/STAT3/CCL2/ IL-6 axis was determined by luciferase reporter, ChIP, RNA-seq, co-IP, in vitro ubiquitination, RT-qPCR array and ELISA analyses.

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PMC11359735

Lanes 7 to 9 were subjected to Western blotting and were used to estimate the position of CSP on the blot.

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PMC10809689

Then, cells were incubated in a 37 °C incubator for 3–4 h. After the incubation time, 100 µL of detergent solution was added to each well to dissolve the ferromazan crystals.

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PMC9325715

Our investigation has revealed that both iron forms, i.e. complexed with bLTF and iron citrate, at the concentration of up to 0.5 mM did not decrease the viability of the Caco-2 and L929 lines in MTT test (Fig. 6).

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PMC11634027

Ds staining in clones of homozygous ds cells was even weaker compared to neighboring heterozygous cells, whereas staining in clones of homozygous ds cells was comparable to that of neighboring heterozygous cells (Fig. S5B,C); these observations are consistent with our analysis of V5 staining.

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PMC11629192

After the second dose of OFA, liver enzyme ALT increased to 136 U/L and normalized within two weeks following treatment with oral hepatoprotective agent.

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PMC9429973

Results: Forty-five RRMM patients were enrolled, 36 of whom achieved minor response or better after 3 cycles of VRd (n=6) or KRd (n=30) and received IRd, and followed up for at least 12 months after the last patient startedinjectable PI-based therapy.

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PMC9436459

The distribution of non-classic MDAAs in mulberry plants is limited, which were only found in the following three Morus plants, M. alba, M. lhou, and M. mongolica.

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PMC11757230

After the incubation period, a Cell Counting Kit-8 reagent (Dojindo, Kumamoto, Japan) was added to each well and incubated for an additional 2 h. The number of viable cells at each time point was measured by the optical density (OD) at 450 nm using a Synergy HT Microplate Reader (BioTek, Winooski, VT, USA).

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PMC4443654

For each cell type we identified 1-Mb regions whose compartment state was altered relative to the other two.

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PMC9429973

Methods: We included patients with hemato-oncological diseases assisted at Hospital de Clínicas and Hospital Maciel from Montevideo Uruguay, who were diagnosed with COVID-19 between march 2020 to February 2022.

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PMC11487720

Cells were washed three times with 1X PBS and then stained for 1 h with fluorescent secondary antibodies, conjugated with red fluorescent rhodamine, Texas red, or Alexa 555 (Molecular Probes/Invitrogen, Eugene, OR, USA).

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PMC11394227

In conclusion, the co-overexpression of HsQSOX1b and survivin improved the protein synthesis in CHO-PAb-QS cells.

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PMC10213179

After incubation the supernatant was discarded and the beads were washed three times (5 min each wash) with lysis buffer.

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PMC9429973

Results: We detected a number of aberrations that were already present at TP1, including del13q, del11q, mutations in NOTCH1, RPS15, ZMYM3, and minor mutations in TP53 and ATM.

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PMC11679892

However, these approaches often come with significant toxicity, particularly in young patients, and are limited in their efficacy for high-risk cases.

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PMC9693627

The reaction was started by adding 2–10 × 10 cells, which were frozen/thawed two or three times in isotonic medium before using.

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PMC10204952

Adipocyte-conditioned cell culture media AD-CM and CAA-CM can reduce nucleic alteration/apoptosis caused by high concentrations of S1P in TNBC cells, and CAA-CM is more potent than AD-CM.

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PMC3931643

Eukaryotic initiation factor 4E (eIF4E), which together with eukaryotic initiation factor 4G (eIF4G) and eukaryotic initiation factor 4A (eIF4A) form the cap-binding complex, is frequently overexpressed in human cancer and can cooperate with the Myc oncogene in an experimental lymphoma model .

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PMC9429973

During the previous decade, several studies explored the role of FDG-PET/CT for detecting nodal and extranodal disease, with only one large study comparing both techniques.

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PMC11779876

Since oligoclonality for TRBC1 and TRBC2 would represent a major obstacle to achieve long term remissions with TRBC1 or TRBC2 directed CAR T cell therapy, we set out to analyze T cell receptor single cell sequencing data of CD3+ sorted T cells from twelve distinct T cell lymphoma cases for TRBC expression.

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PMC4443654

However, other novel feature peaks of interest emerge across cell types, such as peaks of H4K20me1, a modification previously implicated in chromatin compaction .

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PMC11297139

Following commercially available fluorescent-labeled secondary antibodies were used: Alexa Fluor 488 donkey anti-rabbit IgG (A21206) and Alexa Fluor 594 donkey anti-mouse IgG (A21203) (Invitrogen).

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PMC10203589

Moreover, the established multivariate Cox proportional hazard regression model showed that overexpression of FGF18 was significantly associated with longer survival in AEG patients (45).

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PMC11782780

The study was approved by the 2021 Anhui University Natural Science research project (No. KJ2021A1271).

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PMC11564322

Our data revealed that VGVAPG and VVGPGA peptides affected the AKT and ERK 1/2 kinase protein expression in a similar way in all the tested leukemia cell lines.

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PMC11726848

This repair can be executed by different pathways of DNA double-strand break repair, e.g., the pathway based on homologous recombination, non-homologous end joining, and alternative end joining .

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PMC11730000

Consequently, secondary malignant tumors may arise during or after chemotherapy, distinguishing them from primary tumors.

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PMC10605143

These results suggest that in cells with certain mesenchymal features (such as MCF12A), down-regulation of HSF1 can result in adopting epithelial morphology (observed in MCF10A cells).

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PMC9429973

Relapse after ATO/RA based therapy remains very challenging, and novel drug schemes to overcome resistance are urgently needed.

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PMC11127909

The membranes were then washed three times with TBST before incubation with a secondary antibody (1:5000; CST; #7074 and #7076) at room temperature for 2 h. A Bio-Rad ECL detection system was used to examine the signals, and ImageJ (version 1.8.0) was used to analyze the data.

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PMC11790599

Cosimo Commisso found that cancers driven by oncogenic RAS utilize heightened macropinocytosis to augment their nutrient supply and maintain proliferation (Commisso et al., 2013).

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PMC8414691

Fig. 4Abnormal microtubules re-polymerization in SRCAP depleted HeLa cells.

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PMC11055510

This study has shortcomings.

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PMC11172027

With the highest incubation time of 72 h, the IC50% could already be achieved with the use of 125 µg/mL NASeLM (204.0 ± 41.0% vs. 387.5 ± 37.3%) with a significance of p < 0.01 (n = 3).

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PMC4659567

for RuCl3C17H19N2: C, 44.51; H, 4.18; N, 6.11; found: C, 44.32; H, 4.19; N, 5.95%.

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PMC11643491

The greater capability of aggressive and deformable cancer cells to preferentially uptake particles with a high AR, and therefore selectively be eradicated, highlights the potential of ellipsoidal particles to serve as candidates for targeted drug delivery in various biomedical applications.

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