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OTAR3088
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PMC11640476
Additionally, A549 cells have proven instrumental in the production of Adenovirus and contributed to advancements in gene therapy and viral vector research .
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PMC11247842
This could be solved by (1) including the putative causal variants from our findings (Table 5) on the panel for routine genotyping and validate the effect in each population; (2) followed-up by designing molecular biological experiments to confirm the causal relationship.
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PMC6024716
Among the ten identified genes, ornithine decarboxylase antizyme (OAZ1) attracted special attention, because its inhibition improved the expression of luciferase with minimal effects on cell growth and viability.
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PMC10094992
The observed differential expression of these two cytokines deserves further investigation.
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PMC11670407
c, d Representative IHC images of OTULIN and quantitative analysis of OTULIN-positive cells (n = 6) (scale bars: 200 μm and 400 μm).
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PMC9429973
We studied the 23 main HM types (see Figure 1), representing 98% of all HM cases (N = 92.202), diagnosed between 2004 and 2018.
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PMC9429973
Of 81 patients treated with chemotherapy, 97% received anthracycline-containing regimens.
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PMC4816271
Supernatants from these co-cultures were harvested and stored at -20C for subsequent cytokine analysis.
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PMC11656657
In the context of OS, CXCL8 and IL-6 mediate metastatic tropism of tumor cells to lung [31–33].
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PMC9429973
The overall response rate (ORR) post induction therapy was evaluated in 14 patients (one patient was not evaluated for response due to early death), 9 (64%) patients had a complete response (CR), 4(29%) had very good partial response (VGPR) and one had partial response (PR).
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PMC6461034
To assess performance of the INKA approach, pTyr IP‐based phosphoproteomic data were generated and analyzed for four well‐studied cell lines with known oncogenic driver kinases: K562 chronic myeloid leukemia (CML) cells (BCR‐ABL fusion), SK‐Mel‐28 melanoma cells (mutant BRAF), HCC827‐ER3 lung carcinoma cells (mutant EGFR), and H2228 lung carcinoma cells (EML4‐ALK fusion).
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PMC11257988
SOS1 catalyzes the formation of KRAS-GTP complex to activate multiple downstream signaling pathways that trigger cancer cell proliferation.
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PMC11763764
These virus particles contain three to five expression constructs, and each construct encodes a SORL1-specific shRNA.
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PMC11634027
However, our studies also suggest that the ability of Ds to associate with Dachs may not be required for Dachs membrane localization or polarization, both of which are preserved in D-II deletion mutants, despite a significant reduction (74%) in Dachs binding.
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PMC10968586
In nasopharyngeal cancer cell line HNE1 and HONE1, 200 μM OLE enhanced cell radiosensitivity in vitro and in vivo after injection in BALB/C nude mice, with a mechanism involving OLE-dependent removal of HIF-1α hypoxic repression exerted at miR-519d promoter region, upregulation of miR-519d, and miR-519d targeting of DNA damage-regulated protein 1 (PDRG1) .
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PMC11635519
The increase in the cyclic AMP concentration was quantified to evaluate the peptides’ activities.
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PMC5833712
p ≤ 0.05.
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PMC11679033
A total of six replicate cultures for every single experimental group were established.
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PMC10778532
In all cases, p < 0.05 was considered statistically significant.
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PMC9856122
Recently, a nanomedicine containing BBR (NIT-X) was investigated against SARS-CoV and SARS-CoV-2.
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PMC11604768
Meanwhile, the basal transcription rates from Tp53-3 containing promoters in Neuro-2a and MDA-MB-231 cell lines were comparable to negative control promoters, whereas all other cell lines displayed much higher transcription rates (Supplementary Fig. 8B).
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PMC11391695
Following that, a surgical incision was made in the abdominal cavity, followed by the injection of 1 × 10 HCC cells into the designated area of the liver.
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PMC8336407
Besides, it attenuates lipid peroxidation and NO production in t-BHP treated cells.
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PMC8839885
A total of 1 μg RNA was preincubated with 1 μL oligo(dT)17 primer, and diethylpyrocarbonate (DEPC)-treated water was added to a total volume of 15 μL at 70 °C for 10 min; then the mixture was rapidly chilled on ice.
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PMC11258145
Curcumin absorbs light in the UV–VIS range.
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PMC9429973
All individuals signed informed consent to participate in the study.
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PMC6600253
Dyskerin is overexpressed in many human cancer cell types, so it is suitable as a novel treatment for cancer .
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PMC11703992
The “tricycle” package (ver 1.8.0) was adopted to evaluate the cycle state of each cell in single-cell samples .
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PMC8143558
Methanol and ethanol, or the aqueous solutions of both, as well as 100% aqueous solutions, are commonly used as solvents for saponin extraction .
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PMC11361748
One-way ANOVA. (
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PMC11727638
Also, in this study, the two peaks present in the flow cytometry analysis of CD20 expression on TK cells cultured in the Cell Dome (Figure 6a and Table S2) indicate both similar and higher expression levels compared to those cultured in 2D flasks.
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PMC11627398
The AUC of ROC curves for these genes were 0.788, 0.908, 0.749 and 0.914 in the GSE26440 cohort, respectively (Fig 2C).
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PMC11139449
Lane 1; 100 bp DNA ladder, Lane 2; using the forward primer and gRNA-b as the reverse primer, Lane 3; using the forward primer and gRNA-d as the reverse primer, Lane 4; using the forward primer and gRNA-b plus PAM as the reverse primer, Lanes 5 and 6; Empty lanes, Lane 7; using the forward primer and gRNA-d plus PAM as the reverse primer.
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PMC11224020
Bottom, representative images of nonconfined untreated DCs or DCs treated with 2.5 µg ml PGE2 for 30 min in the presence or absence of BI605906 (30 µM).
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PMC11589157
The parsed pairs-files were then sorted by pairtools sort.
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PMC11194678
Taken together, these results establish the robust correlation of overabundant STAU1 with mTOR hyperactivation and autophagy dysfunction via phase separation.
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PMC9429973
HTN in ET was associated with overall thrombosis, especially arterial thrombosis (HR=1.91-3.8).
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PMC11592837
In addition, both automated microscopy as well as cfDNA analysis revealed an earlier drug-specific toxicity in Jurkat cells compared to PBMCs.
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PMC7189327
Nine gene signatures (CYFIP2, HOXB5, EGFR, FOXN3, PTPN3, CDC20, MARCKSL1, FAS, and PTCH1) may serve as promising targets for BCC detection and development.
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PMC9509578
Drug delivery by polymer lipid nanoparticles (PLNs) has been shown to enhance chemotherapeutic efficacy and retention in resistant cells.
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PMC11704834
As compared with control GFP cells, the GFP-TLE1 A549 cells showed enhanced proliferation and reduced apoptosis following gefitinib treatment, signifying that exogenous TLE1 expression conferred gefitinib resistance in A549 cells.
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PMC8903741
We confirm the transfection efficiency of antibody-expressing DNA into cells in a convenient manner by using the GFP-expressing gene as a control.
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PMC10759659
In addition, GSEA showed multiple enriched immune-related pathways, including the IL6 and IFN-γ signalling pathways, in ARID1A-deficient HBV-HCC, which are important for antitumour activity conducted by immune cells, especially T lymphocytes.
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PMC11683240
Gαi was spotted as a known interaction partner of PTS1.
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PMC9429973
Inverse probability of treatment weighting with average treatment effect on the treated was used to adjust for imbalances in prognostically significant baseline covariates: Eastern Cooperative Oncology Group performance status, gender, type of MM, prior transplant, refractory status, International Staging System stage, time to progression on prior LOT, extramedullary disease, number of prior LOT, time since diagnosis, average duration of prior LOT, age, hemoglobin, lactate dehydrogenase and creatinine clearance.
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PMC9429973
We then went on to show that this subset of CD34CD38CLL-1 cells were metabolically distinct from the bulk tumour.
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PMC8343815
In this study, we evaluated the effects of AuNRs and AuNPs on the radiosensitivity of HeLa cells.
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PMC11661040
However, due to the high proliferation and invasive ability of osteosarcoma, its recurrence rate is as high as 35%(Isakoff et al. 2015).
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PMC9429973
In the particular case of BeatAML, gene expression survival models were based on out-of-bag predictions in order to reduce the risk of overfitting during the training phase of the model.
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PMC11519583
d, e Proportion of Ki-67-positive MPs in TA muscles treated with Wnt5b and/or Wnt11 CM after Ctx injection was monitored by flow cytometric analysis.
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PMC11188874
Pharmacologic blockade and genetic ablation of the HDAC6 ubiquitin-binding domain released HR23B, which shuttles ubiquitinylated cargo to proteasomes, while silencing HDAC6 or HR23B in multiple myeloma cells abolished the effect of HDAC6 inhibitors on proteasomes, antigen presentation, and T-cell cytotoxicity.
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PMC11464982
The Panel concluded that the food enzyme endonuclease did not induce gene mutations under the test conditions applied in this study.
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PMC11543935
Further studies could investigate different ablation parameters or techniques and the cellular response to the thermal influences.
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PMC11548041
Cells were stained with 1:50 EpCAM-AF647 (Cell Signaling, Danvers, MA, USA) or IgG1-AF647 isotype control antibody (R&D systems, Minneapolis, MN, USA) for 1 h on ice, then washed, and analyzed using NovoCyte flow cytometer (Agilent NovoCyte 2060, Santa Clara, CA, USA).
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PMC11591030
This is attributed to the Nrf2 blockade downstream and the subsequent reduction in antioxidant enzyme activity.
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PMC11388384
Therefore, the topology-limited diffusion model represents a general framework for understanding the basis of morphogen diffusion, and unifies morphogen gradient models that were previously considered to be incompatible.
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PMC11470999
By selecting appropriate modeling methods, we can better study the mechanisms of melanoma cell survival in the circulation and growth and adaptation in the specific brain microenvironment, bringing new therapeutic options and hope to cancer patients with brain metastasis.
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PMC11750712
The plates were centrifuged at 1,000g for 40 min.
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PMC11549612
As depicted in Figure 3A&B, the up-regulations of BOLA1, BOLA2, and BOLA3 were significantly linked to shorter OS and RFS in KIRC patients. -
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PMC9429973
Overall, grade ≥3 AEs occurred in 62% of pts with I+V and 90% with FCR.
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PMC11703992
Thus, it can be assumed that the CD4+ Memory T cells exert similar biological and clinical functions in GCA and old groups.
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PMC10747160
Although HIV lentivirions and SARS-CoV-2 virions share many similar features, they do differ in the number and type of proteins that are incorporated into the final virion .
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PMC11612315
This concept is further illustrated in Supplementary Fig. 6, which highlights the potential binding sites for each GLP-1 analog in orange, emphasizing their role in pain modulation.
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PMC11746948
b Cell viability analysis in A375 cells pre-treated with 2-BP for 24 h, followed by 48 h treatment with GPX4 inhibitors (RSL3, ML162, ML210) and SLC7A11 inhibitor (erastin).
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PMC11653533
In addition, the extract from the leaves of F. racemosa has demonstrated its ability to shield the liver in rats that have been subjected to long-term damage caused by carbon tetrachloride, while, SGOT, SGPT, Alkaline phosphatase, and Bilirubin levels were 58.4 ± 1.1 IU/L, 41.2 ± 1.1 IU/L, 65.7 ± 1.2 U/L and 2.5 ± 0.03 g/L respectively (Mandal et al., 1999).
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PMC9429973
Descriptive statistics were applied.
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PMC4270159
Remove the gel from the cassette and rinse with water.
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PMC11361748
n = 3 mice.
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PMC11755519
EMT, epithelial–mesenchymal transition; EV, extracellular vesicles.
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PMC7136814
RMS is comprised of two main histological variants, alveolar and embryonal (ERMS).
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PMC11225860
•Alisertib, an ATP site inhibitor of Aurora A kinase, induces cell cycle dysregulation and polyploidy in Diffuse Large B Cell Lymphoma.•The combination of alisertib and Aurkin A, an Aurora A TPX2 site inhibitor, prevents polyploidy and increases apoptosis.
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PMC11786600
Thus, PED4 effectively corrects imbalances in wound immunomodulation, reduces inflammation, and promotes neovascularization and collagen deposition, ultimately leading to optimal DFU healing.
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PMC9429973
Treatment was well-tolerated.
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PMC11705862
In the neuroblastoma cell line (SH-SY5Y), both isoforms are intracellular, and their expression increases upon differentiation into mature neurons.
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PMC11519583
Therefore, it is important to investigate whether the difference in inflammation might affect specific Wnt expression patterns.
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PMC11737091
The hallmark gene set enrichment results revealed that high DBF4 expression is associated with the activation of pathways, including E2F targets, the G2M checkpoint, the inflammatory response, IL6/JAK/STAT3 signalling, and apoptosis, and the inhibition of pathways, including the oestrogen response early and adipogenesis (Fig. 4C).
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PMC11001582
The arginine-rich DPR proteins, polyGR and polyPR, are generally the most toxic species in several systems, including Drosophila, mammalian cells and mouse models.
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PMC9429973
The most common side effects were diarrhea (75%), rush (50%) and electrolyte disturbances (37,5%).
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PMC11489175
In spite of the efficacy of the combination, drug resistance can develop 2.
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PMC9429973
Moreover, the patients aged 70 years old over were 56 %.
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PMC5363531
Thymidylate synthase (TS), one of the key enzymes for thymidine synthesis, is a target of pemetrexed (PEM), a key agent for the systemic therapy of malignant pleural mesothelioma (MPM) and its overexpression has been correlated to PEM-resistance.
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PMC7185206
By flow cytometry, 786-0-PD-L1-GFP cells treated with this broad inhibitor maintained more intact PD-L1 as evidenced by abundant GFP/Alexa647 cells versus vehicle-treated control (Figure 2(c), Supplemental Figure 5a-b).
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PMC9739791
Under white light irradiation (400–760 nm, 4 mW/cm) after 5 h, only 4% of 6b and 9% of 6c were reduced to carboplatin, while 6a was barely reduced.
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PMC11799620
Unfortunately, cadmium exposure harms cannot be treated.
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PMC11635519
Lentiviruses were made in a 15 cm dish format by transfecting HEK293T packaging cells with a three-plasmid system as previously described.
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PMC9429973
Interestingly, it was found that all but one (6/7) ctDNA-specific subtype belonged to the MCD subtype.
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PMC11401358
Compared to SF without heating, the ability of SF-95 °C to scavenge •OH was significantly increased in all the groups as long as SF concentration was above 1 mg/mL (Figs. S22A–D).
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PMC11297139
The eleven-nineteen-leukemia (ENL) protein possesses the Yaf9, ENL, AF9, Taf14, Sas5 (YEATS) domain that is a reader module recognizing histone lysine acylation selectively.
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PMC11627133
To visualize endogenous proteins within cells, RhoBAST can be combined with a protein‐binding aptamer directly targeting the protein of interest.
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PMC8592717
Diabetes-induced neurobehavioral and biochemical dysfunction was also alleviated by PCA administration by improving the endogenous antioxidant status; inhibition of lipid peroxidation; and downregulation of acetylcholinesterase, inflammation, and caspase-3 activities .
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PMC10956161
A volcanic plot was used to identify the top 10 upregulated and downregulated genes in lung adenocarcinoma.
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PMC9429973
Although some differences have been reported between CD30-expressing lymphoma populations in Western Countries and East Asia, there is limited information on Chinese patients.
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PMC10094992
In each well 1 × 10 cells were seeded in 100 μL of RPMI 1640 medium, supplemented with 1% L-Glutamine and 1% penicillin-streptomycin and 10% of FBS.
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PMC11476004
Fifty cells were analysed for each animal.
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PMC10914904
Simultaneously, a cytosolic form of microtubule-associated protein 1A/1B-light chain 3 (LC3-I) conjugates with phosphatidylethanolamine, giving rise to the LC3-phosphatidylethanolamine conjugate (LC3-II), which is incorporated into autophagosomal membranes.
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PMC10470467
At the end of the study, we performed univariate and multivariate Cox regression analyses on the clinical data (including age, gender, and state) and risk-score to evaluate whether the signature could be utilized as an independent prognostic factor.
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PMC5311252
These findings have several potential clinical implications.
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PMC4659567
for RuCl2C17H20N2: C, 48.12; H, 4.75; N, 6.60; found: C, 47.76; H, 4.74; N, 6.37%.
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PMC11615218
In another study, single-cell transcriptome sequencing of CAR-T cell infusions in R/R LBCL patients revealed an elevation of the CAR-TREG population among non-responders .
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PMC11588085
We validated the loss of XIST expression in cells with sgXIST7 and sgXIST9 (Fig. 3A).
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