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BioData-CellLine_annotated

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PMC11612626
CD138 cells were isolated from patient bone marrow using the EasySep Human CD138 positive selection kit II (StemCell Technologies, #17877) according to the manufacturer’s guidelines.
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PMC11765988
Overall, granuloma initiation and disease progression are driven by Th1 cytokines, while dysfunctional Tregs (which support immune regulation) and enhanced Th17 response may contribute to granuloma persistence .
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PMC6889484
Table 1Frequency of Hypermutated Clones and G-to-A Hypermutation Profile for A3G-D128K, A33G-D128K, and A3x3G-D128K Virus Produced in the Absence or Presence of Vif2Vector and Presence or Absence of Vif2No.
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PMC11023271
The day after treatment, cells were harvested and fixed in cold 70% ethanol, followed by treatment with 10 μg/ml RNase A and 20 μg/ml propidium iodide, based on established protocols .
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PMC11502066
Although a great advantage of flavonoids lies in their relatively good safety profiles with only minimal side effects , these compounds undergo a complex intestinal absorption and extensive bioconversion in the human body, revealing only poor bioavailability and low plasma concentrations.
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PMC11682525
SH-SY5Y cells were similarly preconditioned for up to 72 hours.
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PMC11488203
Quantification of the amount of exosome production was also determined by NTA and calculated as released exosomes per cell per 24 h. The fold differences (increase) of taxol-loaded exosomes as compared to the corresponding untreated control exosomes are indicated above the taxol bars (C).
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PMC10551595
Results are reported as the mean ± SEM of three independent experiments performed in triplicate. *
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PMC9429973
Among COVID-19 patients, 30% discontinued on TKI treatment during COVID-19.
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PMC11783017
It is considered that typical biomarkers of ICD, molecules such as ATP, CRT, and HMGB1 can induce dendritic cell maturation and activate cytotoxic T lymphocytes, thereby promoting immune responses .
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PMC11727907
ARPE-19 cells, an ex vivo model of human pigmented epithelium, were exposed to IGF-1.
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PMC11407042
Discard the supernatant and resuspend the cell pellet in 10 mL pre-warmed FBS-containing DMEM.
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PMC11742290
A study has found that glucose deprivation altered the glycosylation status of LGR5, resulting in reduced protein stability and cell surface expression .
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PMC11471176
Thus, only 4th and 5th passage cells were used in the study.
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PMC11300639
j, k 786-O cells were transfected with indicated constructs for 72 h. Cells were harvested and treated with a serial dose of Everolimus for 24 h to measure the IC50 values of Everolimus.
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PMC11656048
Therefore, we wondered whether ferroptosis was participated in the shikonin mediated anti-OS activities.
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PMC10887351
As showed in another work by us, in the TME, β3-ARs could control the tumor stroma differentiation, suggesting a new strategy to neutralize melanoma progression by increasing together differentiation processes and cell death .
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PMC9429973
Strata were assessed for molecular relapse (MolR) with Kaplan-Meier estimates and with cox regression analysis including a frailty term for correction for between-study heterogeneity and including confounding variables: age at diagnosis, gender, Sokal score, TKI generation, treatment duration, DMR duration (model 1) and BCR::ABL1 transcript type (model 2).
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PMC11745823
Control experiments involved infecting cells with either an empty vector or scrambled shRNA sequences.
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PMC6450504
Phycoerythrin-conjugated anti-P-glycoprotein antibody [UIC2] was purchased from Abcam (Cambridge, MA).
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PMC11687167
Sun et al. demonstrated that PCSK9 has anti-apoptotic effects in mouse liver.
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PMC10772747
Cell Cycle Analysis Cell cycle analysis was performed using flow cytometry with propidium iodide (PI) staining.
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PMC9429973
There is a significant knowledge gap regarding diagnosis, management, and outcomes of LGLL.
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PMC11387401
Negative scores are depicted in white.
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PMC7887261
There is no increasing DNA damage in MPZL2 knockdown cells.
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PMC11711871
Indeed, soluble epoxide hydrolase (sEH) catalyzes the hydrolysis of polyunsaturated fatty acids to less active diols and is implicated in metabolic and cardiovascular diseases .
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PMC9429973
Prior refractoriness to proteasome inhibitors was allowed.
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PMC11593713
The cell lines used for test virus suspension preparation were cultivated in 175 mL flasks (NEST SCIENTIFIC Biotechnology, Woodbridge, NJ, USA).
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PMC9429973
The enrichment analysis suggested that DNMT3A and NPM1 mutations, in a constitutive FLT3 expression context, cooperate to activate transcriptional programs sustaining the proliferation and maintenance of blasts through concerted upregulation of a number of pathways, including the Anaphase-Promoting Complex (APC), which regulates cell cycle progression, the m-TOR-mediated autophagy inhibition, the Rho-GTPases effectors (with Rac1 overexpression), the Hippo-mediated self renewal, the HOXA9 signature and TP53-regulated apoptosis.
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PMC9429973
Fifteen (26%) patients received an antiviral drug, while 4 (7%) hospitalized patients received monoclonal antibodies for the treatment COVID-19.
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PMC11743975
We proposed a novel system that employs blue light to rapidly control mitochondrial aggregation and to study how that perturbation affects cell function.
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PMC11687663
We also detected minor number of amino acids, ascorbic acid, and trace element but excluded from the analysis.
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PMC10114490
However, when cultured with low serum, cells did not reach confluence after 6 days, and the percentage of Ki67-positive cells drop to approximately 30% (37.9 ± 14.2 and 28.4 ± 8.5 for PD and PD, respectively, not significant, n = 9).
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PMC11687663
Natural products are the main source of potent anticancer medications with innovative structures and distinct modes of action for the treatment of different types of cancer.
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PMC10936243
The explanation may be that clients have limited funds (Kipperman et al. 2017; Hardefeldt et al. 2018), or that resources such as drugs (Lascelles et al. 1999), or staff recruitment (Kinnison et al. 2015) were prohibitively high.
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PMC11476264
Human embryonic kidney cell HEK293T and human lung adenocarcinoma cell line A549 cells were cultured in DMEM (Gibco, Waltham, MA, USA, C11995500B) with 10% FBS (Kangyuan Biotechnology, Shanghai, China, KY-01000).
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PMC11633763
For example, research by Bartman et al. shows that in human xenografts derived from pancreatic cancer, lung cancer and colorectal cancer, there is a high level of glycolysis, while oxidative phosphorylation is significantly inhibited.
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PMC11591052
For these experiments, 30,000 cells per well were seeded on 24-well SeaHorse plates in five replicates and treated with 1–100 μM of 20E for 24 h. The final concentrations of both oligomycin and the Rotenone/Antimycin A mix were 3 µM. To quantify glyco- and mitoATP production, the SeaHorse XF Real-Time ATP Rate Assay Excel plugin (Agilent, Santa Clara, CA, USA) was used.
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PMC11678368
The DFT computations have been of great assistance to spectroscopic measurements.
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PMC11476106
In HGs with added VN, there was low-intensity interterritorial VN (+) without a clearly discernible crown at 2 weeks (Figure 2F).
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PMC7961460
Samples were pre-cleared with 50% G-Sepharose beads in RIPA buffer + protease inhibitors for 2 h at 4 °C on an orbital shaker.
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PMC11680562
The supernatant was removed through centrifugation at 5000 rpm for 10 min.
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PMC11144382
These findings may help to provide some explanations for the occurrence of the range of skeletal and neuronal phenotypes in MSS patients as follows.
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PMC11394386
Currently, more than 39 international clinical trials are ongoing, mainly in phases I and II.
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PMC11342785
The mean was determined from data pooled from five representative images.
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PMC11699178
In the oe-HIF-1α + GEM group, these levels increased, while silencing FGFR1 led to a reduction in FGFR1 only (Fig. 5C, D).
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PMC11610461
Specifically, the activation of AMPK by metformin and the inhibition of PKM2 under glucose deprivation conditions yields better therapeutic outcomes in patients with renal cell carcinoma (Liu et al., 2019).
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PMC11708541
One of the compounds in the collection with promising drug-like properties produced was methylsulfonyl bipyridine amine 38 is undergoing clinical testing to treat malaria.
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PMC10747160
Because Griffithsin, much like DC-SIGN, is also a lectin that binds to sugars on viral glycoproteins, we theorized that Griffithsin could act as a potent competitive inhibitor of DC-SIGN-mediated trans-infection (Figure 4B) .
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PMC9429973
Pts received treatment until disease progression, unacceptable toxicity, or withdrawal.
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PMC11463018
HR-MS (ESI) calcd.
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PMC8751435
Correspondingly, caspase‐3 activity and caspase‐3 downstream proteins including pyroptotic effector gasdermin‐E (GSDME) and apoptotic marker cleaved‐poly‐ADP‐ribose polymerase (PARP) are significantly promoted by CME.
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PMC11648299
Patients with DD have an increased risk of epilepsy, mild intellectual disability, diabetes, and heart failure and the disease has thus been suggested as a multiorgan systemic condition .
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PMC9429973
It has been demonstrated that the PD-1/PD-L1 expression was upregulated by HMAs in MDS pts, providing a strong rationale for combining HMAs with PD-1 antibody for MDS treatment.
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PMC11705067
FDX1 as a potential target for mitotane and DLAT as a potential target for NADH, radiaticol, and dihydrolipoic acid were predicted by DrugBank database.
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PMC11594074
CCRF-CEM cells were seeded in 6-well plates and treated with 0.5 × IC50, 1 × IC50, or 2 × IC50 of compound 4, with DMSO as a negative control.
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PMC7987994
Nevertheless, MEM is the medium designated for the cultivation of L929 cells recommended by the ISO standard and moreover, by its Na, bicarbonate and glucose concentration is closer to human plasma (Table 3) and thus, closer to clinical conditions.
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PMC11665555
Considering the contrasting roles of βHB, better understanding of the metabolic processes in BCa therapeutic resistance is needed.
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PMC11699042
Only promoter regions containing at least five CpG sites were considered for this analysis (default setting of the mCSEATest function).
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PMC10291556
Dimethyl sulfoxide (DMSO) was added to the dried Pt(IV) complex 2.
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PMC11599565
The cells were cultivated in Neuropan medium after the enzymatic isolation from rat brains.
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PMC9219615
Additionally, vehicle (1% v/v DMSO), actin polymerization inhibitor (5 μg/mL Cytochalasin-D), tubulin stabilizer (1 μM Paclitaxel), and untreated controls were included.
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PMC9429973
Initial results for Phase II were previously reported at EHA 2019 (Mehta et al., EHA 2019, # PS1073).
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PMC11283030
Covarrubias et al. found that AKT-mTORC1 signaling axis could regulate ACLY activation and expression to integrate metabolic input in M2 macrophage from mice .
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PMC11683130
In normal skin, SerpinB13 expression is mainly confined to the basal layer, while in diseased skin, it is mainly distributed in the outermost layers of granular and upper spinous layers (127).
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PMC11724582
Beas-2B cells were cultivated in DMEM (Cat.
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PMC11670407
f Western blot results and semiquantitative analysis of the band density for 143B cells transfected with the shRNA-OTULIN lentivirus.
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PMC9429973
In VIALE-A and VIALE-C, baseline demographics were generally similar in Ven-treated pts regardless of post-remission G-CSF use (Table).
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PMC11541241
Over the past decades, extensive research has demonstrated an emerging pivotal role of this pathway in plant disease control.
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PMC11394227
The SDS-PAGE employed was 4–20% Bis-Tris precast page gel (Adamas, Shanghai, China) with a voltage of 180 V, running to the bottom of the page for approximately 50 min.
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PMC8728081
The XRD (Fig. 2g) of Kajjali illustrated that major phases contained in Kajjali were the β-cinnabar (52.32 wt.%), orthorhombic sulphur (44.32 wt.%) and 3.32 wt. %
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PMC9019892
Because of advancements in next‐generation sequencing technology, it has been found that secondary mutations of kinases are not the only mechanisms of drug resistance and that the activation of alternative pathways can also contribute to drug resistance.
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PMC11699178
Therefore, this study underscores the significance of HIF-1α as a key gene modulated by GEM in influencing ovarian cancer progression.
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PMC9812014
Several alkaloids have been reported to have a potent antiviral effect on HSV-I. In a study understanding the effects of different phytochemicals i.e. flavonoids, plant phenolics, and alkaloids, it was shown that alkaloids of several types show good antiviral activity against HSV-I in the MDBK cell line.
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PMC11534377
For a period of 30 days, the development of the subcutaneous xenografts was monitored through bi-weekly measurements of tumor diameters.
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PMC11625890
I made the decision to go straight into studying my current PhD at the Roslin Institute in Edinburgh, investigating neuropathological processes related to ageing in both cats and sheep, along with potential predisposing genetic factors.
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PMC11462929
Hi‐ChIP assay in five BCP‐ALL cell lines with different MYC gene expression levels and BENC copy number statuses.
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PMC10222971
A remarkable increase in apoptotic cell number (UL + UR quadrants) was observed compared to the untreated cells.
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PMC4277423
The file contains locations of coding regions of all RefSeq genes in the GRCh37/hg19 human genome.
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PMC11206502
A total of 200 cells were analyzed per HB treatment or control (Figure 8).
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PMC7519871
Key elements involved here are nuclear factor-kB (NF-kB), MAPK pathways, Bcl-2 family and Bcl-xL family proteins (Figure 12A–C).
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PMC10092581
Cell monolayers were harvested, washed with PBS and centrifuged.
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PMC11269933
The in vivo kinase experiment demonstrated that the more pronounced migration bands observed when co-transfected with CgERK1/2 and CgPK than that with lane 1 that transfected with CgPK alone, and the migration bands of CgPK mutant showed no significant changes regardless of co-transfection with CgERK1/2 (Figure 4E).
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PMC9429973
The disease status was progressive disease (PD)in all patients who failed to multi-line therapies.
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PMC11596967
However, at a dose of 8 Gy, there was a significant increase in both late apoptotic and necrotic cell deaths (Figure S2).
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PMC7039683
For instance, there is a zGPAE near cyt1, a gene with higher expression in GFP-positive versus GFP-negative cells (Figure 1—figure supplement 7A) and there is a GNAE near her4.3 with the opposite expression trend (Figure 1—figure supplement 7B).
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PMC11240571
In addition, we previously reported that a high level of sPD-L1 predicted future metastasis and a poor prognosis in soft tissue sarcoma patients .
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PMC10006224
Cells were harvested 72 h after transfection and analyzed by flow cytometry, as described below.
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PMC11718031
Pepperell, MA).
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PMC11575040
I OS analysis of patients with melanoma (458 patients, TCGA) was conducted using Kaplan–Meier survival analysis By using the OSskcm database, we examined the association between the expression level of metformin-regulated lncRNA and the overall survival (OS) and disease-specific survival (DSS) of patients with melanoma.
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PMC11777207
We identified KikRed cDC1s (XCR1CD11b) in the dLN and saw no significant differences in frequency or number of cDC1s between αPD-1– and isotype-treated mice (Fig. 3, L to N) consistent with our human DC migration assay (Fig. 1).
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PMC11321678
At the bulk level, we annotated motifs in all peaks using the cisBP database and then constructed a binary matrix where the presence of a motif is indicated numerically in each peak.
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PMC8973085
For example, prasugrel, and ticlopidine and clopidogrel (Figure 2) were reported as antiplatelet drugs.
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PMC11755467
Thereby, miRNAs may affect the virus directly, by targeting viral transcripts, or indirectly by targeting cellular factors required for the virus replication (reviewed in ).
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PMC9261184
While methane slip across the engines was highly variable, the engines performed similarly to the manufacturer’s specifications or pre-engine tests.
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PMC8633974
The particles were analysed by transmission electron microscope (TEM) (FEI Tecnai G2 Spirit) after Nanovan® (Nanoprobes #2011-5ML) stain.
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PMC10957991
Mean (+ /− SEM) is shown. *
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PMC11033180
Neurons were subjected to incremental current injections lasting 500ms, starting from a baseline current of −50 pA and gradually increased by 10 pA at a frequency of 0.1 Hz until action potential (AP) firing occurred.
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PMC9429973
Aims: This Australasian Leukaemia and Lymphoma Group (ALLG) laboratory science correlative study LS21 seeks to determine if the baseline molecular profile by whole exome sequencing (WES) can predict primary resistance to zanubrutinib, and whether the emergence of resistance mutations in circulating tumour DNA (ctDNA) can herald clinical progression.
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PMC10975211
Researchers have explored the development of buforin-containing bioconjugates as innovative therapeutic strategies for cancer treatment to enhance their efficacy and specificity further.
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