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PMC11806182
Validation was performed using experimental data from Ishikawa cells treated with six candidate drugs.
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PMC9429973
Awareness of SCD was 5 times higher among African respondents (92% versus 66%, OR 5.3 CI 2.7-10.5, p<0.0001).
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PMC11766174
Nonetheless, it is not more costly than flow cytometry.
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PMC11655536
Cells were treated with increasing concentration of carfilzomib (Cfz, 0.075 µM, 0.015 µM, 0.03 µM) and HA (2 µM, 4 µM, 8 µM) alone or in combination for 48 h. G Cell viability of ARH-77 cells were treated with carfilzomib (Cfz, 0.025 µM, 0.05 µM, 0.1 µM) and HA (5 µM, 10 µM, 15 µM) alone or in combination for 48 h. Cell viability was performed by CCK-8 assay.
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PMC11489351
To identify TFs likely to be posttranslationally regulated by pHi, we analyzed our RNA-seq dataset using the TF mode in Metacore (see Methods).
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PMC10728200
G The representative images of proximity ligation assay (PLA).
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PMC11365427
For phenylalanine starvation, a phenylalanine-free RPMI-1640 medium containing 10% FBS and antibiotics was used.
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PMC11682172
Furthermore, protein expression in primary breast cancer tissues was explored and related to brain-metastatic potential.
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PMC11536589
The specific siRNAs used were MGST1-siRNA1 (sense: CGAACAGAUGACAGAGUAGAATT; antisense: UUCUACUCUGUCAUCUGUUCGTT), MGST1-siRNA2 (sense: CUUGGAAUUGGCCUCCUGUAUTT; antisense: AUACAGGAGGCCAAUUCCAAGTT), and SiNC (sense: UUC UCC GAA CGU GUC ACG UTT; antisense: ACG UGA CAC GUU CGG AGA ATT).
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PMC11747949
Data were analyzed using FlowJo.
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PMC7351993
Fig. 1Schematic of the RIACS.Suspended cells injected into the RIACS are focused by the hydrodynamic and acoustic focusers into a single stream, detected by the event detector, imaged by the ultrafast multicolor SRS microscope, analyzed by the real-time Raman image processor, and sorted by the dual-membrane push-pull cell sorter triggered by decisions made by the real-time Raman image processor composed of multiple FPGAs, CPUs, and a network switch, all on a 10-Gbps all-IP network for high-speed digital image processing and decision making.
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PMC11261875
2PG: 2-phosphoglycerate; 3-BP: 3-bromopyruvate; ENO: enolase; Fructose 6-P: fructose-6-phosphate; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; Glucose 6-P: glucose-6-phosphate; LDH: lactate dehydrogenase; MCT: monocarboxylate transporter; PEP: phosphoenolpyruvate; PFK: phosphofructokinase; PK: pyruvate kinase As discussed in this review, the critical association between GIST and glycolysis is yet to be fully elucidated.
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PMC11513011
Fig. 5Anti-tumor effects of DIB in mice.
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PMC11344246
Key subgraphs of the MOC co-expression weighted interaction network identified by PCSF analysis.
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PMC11675244
CSCs are often found near myofibroblasts, which are thought to secrete factors that promote β-catenin-mediated transcription, suggesting the tumor microenvironment (TME) is involved in CSCs clonogenicity .
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PMC11806818
In recent years, nanozyme aptasensors have been developed, mimicking the principles of enzyme-based immunoassay in terms of target detection and signal amplification.
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PMC11361748
The PCR parameters for qRT-PCR screen were 95°C for 5 min, followed by 40 cycles of 95°C for 10 s and 60°C for 30 s. No cDNA template controls and a melt curve were included in every PCR run.
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PMC11279598
We found that MH and powder inhibit cell proliferation in a dose-dependent manner in vitro and in vivo.
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PMC8584319
Therefore, it is essential to elucidate the signaling pathway of mTORC1/2 inhibitors to provide an accurate clinical prognosis.
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PMC11173119
Furthermore, we differentiated stem cells into macrophages and analyzed the morphological differences between macrophages harboring mutated MEFV compared to those with wild-type MEFV.
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PMC9479186
While senescence is always combined with dysfunctional mitochondria, the changes are not yet fully understood.
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PMC9388315
At a concentration of 1.25 mg/ml, the decrease was not significant compared to the control group (P > 0.05).
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PMC10033453
In addition, we codon optimized the full-length genome of VMG to enhance the translation of viral proteins in mammalian cells.
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PMC9429973
We would be very interested to see if these differences are replicated in other diagnostic services both within the UK and also in other languages.
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PMC11597167
The inhibition of BACE1 activity suggests that quercetin may give a pre-clinical clue for potential therapeutic value in AD by reducing the accumulation of Aβ plaques in the brain.
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PMC11626627
Data are presented as mean ± SD. *
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PMC7757104
Additionally, silencing of OPNc impaired cell proliferative and colony formation abilities, as well as reversed the expression levels of EMT markers and EMT-related cytokines compared with those in the negative control cells.
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PMC11066331
For DT, an algorithm with a root node, five internal nodes, seven leaf nodes, and three dominant variables (4909, 4939, and 8402) was used.
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PMC9844987
B–C) Sequence logos of two metaclusters (top) identified for highly variable promoter sequences that match known TF motifs (bottom) for PTF1A and ASCL2 (B) and FOSL2-JUND and FOS-JUN heterodimers (C). (
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PMC9429973
Treatment-related AEs were mainly of CTCAE grade 1 or 2 in intensity.
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PMC11730311
Schild regression analysis was used to compare antagonism of hαCGRP8-37 and hαCGRP8-37N25K-C20DA-γGlu (Fig. 7a–d).
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PMC7685376
None of the patients received radiotherapy, chemotherapy, or other treatments before surgery.
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PMC11451829
Surgery is the definitive treatment for pterygium; therefore, reliable animal models are required for translational research.
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PMC11461833
A–D) HA-progerin-expressing HEK293 cells were transfected with one of three STXBP5 guide RNAs (STXBP5 guide1, STXBP5 guide2 or STXBP5 guide3) or a control guide RNA (gAAVS1) and selected with puromycin for 3 days to obtain a cell line with stable knockdown. (
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PMC11194678
Charge and hydrophobe distribution diagram of STAU1. (
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PMC11532793
Another disadvantage of bootstrapping is potential loss of resolution for genes with low coverage or for genes where all the sequence reads are assigned by chance to a single EC.
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PMC8414691
These mutations are supposed to produce a C-terminal-truncated SRCAP protein variant missing the AT-hook motifs with DNA-binding activity and are possibly responsible for a dominant negative effect triggering the onset of FHS .
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PMC11750165
Whole-mount in situ hybridization showed that the number of GABAergic KA” neurons meaningfully increased in the p3 domain of PEX1-MO injected embryos at 25-hpf (~1.4±0.2-fold, mean±SD, p<0.05, n=7) (Fig. 3B).
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PMC8345486
A significant decrease in growth rate was also found in the A2780cisR cells cultured with the reference compounds 25 (p < 0.05, Figure 8B) and 2 (p < 0.01, Figure 8A,B).
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PMC4695073
These results suggest XPA likely correlates with cisplatin resistance in NPC cell lines.
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PMC11684269
In the cardiac microenvironment of myocarditis, characterized predominantly by inflammatory cytokine infiltration, inhibition of PGK1 in CD4 T cells can alleviate cardiac inflammation and fibrosis (78).
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PMC9429973
The more prevalent inherited risk factors are the gain-of-function mutations in coagulation factors V and II, namely factor V-Leiden (FVL and/or F5G1691A (FVR506Q,)) and prothrombin/Factor II (FII) F2G20210A.
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PMC11342785
G, quantification of GFP-TPPP variants from (F) with respect to droplet fluorescence signal intensity.
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PMC9429973
Although this combination is not approved as first line for younger patients, it may be an alternative is situations where chemoresistant disease is predictable.
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PMC11471176
Moreover, Jiang et al. revealed a post-infection reduction in ACE2 expression following severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) infection.
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PMC11704834
Since EMT is a known determinant of acquired EGFR-TKI resistance in lung cancer cells (14,20) and considering the present findings that E-cadherin repression, a hallmark of EMT, underlies the TLE1-mediated gefitinib resistance in A549 cells, a possibility remains that TLE1 may contribute to gefitinib resistance in A549GR cells via EMT.
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PMC9429973
Determining antitumor activity in patients with WM and AL amyloidosis is an additional primary objective of part 1 monotherapy.
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PMC11658074
g The fluorescence intensity reflects the level of intracellular ROS production after intervention and UVB irradiation.
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PMC9429973
We observed reduced GM alpha diversity, and depletion of bacterial members of Lachnospiraceae and Ruminococcaceae families among the CLL patients when compared to healthy individuals.
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PMC9429973
Further studies will enable us to define immune profile characteristics associated with a high risk of EBV-LPD and point toward potential strategies to prevent these disorders in select patient populations.
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PMC9646302
Lysosomal-associated transmembrane protein 5 (LAPTM5), also known as E3 and CD40-ligand-activated specific transcript, is a member of the LAPTM family.
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PMC11092382
The main active ingredients include matrine, oxymatrine, sophocarpine, and oxysophocarpine.
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PMC11371747
Excess dye was washed away four times with 1% acetic acid and plates were dried again.
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PMC9164404
To understand this, RNA-seq analysis was performed on BEL-7404 cells treated with PBS, cisplatin, and Abplatin.
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PMC8041314
The 1049 compounds served as a validation data set for “Positive Patterns” (Screen 2) and “Negative Patterns” (Screen 3), which were applied as multitarget fingerprints.
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PMC10813895
Whereas, the ELF5 promoter is methylated in myoepithelial cells, and ELF5 expression is silenced .
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PMC11765879
Briefly, fertilized White Leghorn chicken eggs (Arab Qatari for Poultry Production, Doha, Qatar) were incubated in a rotating MultiQuip Incubator with 60% humidity at 37 °C for five days.
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PMC11301242
We then compared the expression levels of these genes in cell line samples, both with and without circular amplification, within the context of the same disease.
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PMC9429973
Twenty-six patients were treated with Bamlanivimab/Etesevimab, 17 with Casirivimab/Imdevimab, 3 with Bamlanivimab, and 2 with Sotrovimab, for 3 patients data were missing.
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PMC5173112
In addition, it was demonstrated that USP21 directly targets IL-8 in RCC cells.
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PMC6835428
Finally, PGA is water-soluble and has low immunogenicity and low toxicity; thus, it is an attractive candidate for siRNA release.
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PMC11049294
Therefore, in women the mean AGAL activity moves in a wide range from normal to very low, resulting in a limited screening value .
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PMC11583690
To confirm that there were no changes in particle morphology and size after loading DTX onto BPMO and MSN particles, SEM imaging was conducted on BPMO@DTX and MSN@DTX (Fig. S1).
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PMC11502962
CD3 T cells and macrophages have been found as the most abundant tumor-infiltrating immune cells in GIST (11, 12).
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PMC10809689
The was used to calculate the relative expression of each studied gene.
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PMC10243817
We found that MEX3B was mainly expressed by nasal epithelial cells, and its expression was upregulated in patients with CRS compared with control participants by immunofluorescence staining (Figure 1A).
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PMC11089031
All those assays were repeated for three times To further explore the role of ZNF692 in ccRCC, we analyzed scRNA-seq data from normal human kidney tissue using the scRNA section of The Human Protein Atlas.
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PMC11678130
The possible mechanism of action of 5-FU, QUE, and their combination on A375 cells is presented in Figure 9.
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PMC9429973
In an analysis of a large public dataset of ex vivo patient samples, the presence of NPM1m and/or FLT3-ITD was significantly predictive of response to ENTO.
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PMC10568263
This finding underscores the ability of Au@MnO2/MoO3 nanocomposites to facilitate electron transfer and offer a substantially increased effective specific surface area.
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PMC7582629
The strong negative amide III (at 1247, 1270/1278 band ratio and 1438 cm) Raman bands suggest a decreased HER2 amplification when control (HER2− control and HER2+ control) cell spectra were subtracted from that of BT474 cancer cells.
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PMC11629461
Cell‐Tak (#354241), the cell adhesive for cell attachment to cover slips, was bought from BD Bioscience (RRID: SCR.013311, Bedford, MA, USA); alternatively, Matrix‐gel was used (#C0372) (Beyotime, Shanghai, China).
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PMC11046454
Innovating CAR design is critical for addressing current limitations in CAR T-cell therapy.
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PMC11247842
One such strategy is using phenotype related and tissue specific RNAseq dataset to prioritize candidate genes.
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PMC8592717
PCA alleviated cadmium (Cd)-induced cortical toxicity in male rats through activation of the antioxidant defense system and suppression of the inflammation and apoptosis mediated by the Nrf2/ARE pathway .
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PMC11740399
The study demonstrated that 3025@ML significantly enhances the anti-tumor activity of OXA.
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PMC10040136
100 mm cell culture dishes were planted with 1 × 10 GIST-882 cells per dish.
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PMC9429973
Both human and murine acute GVHD are characterized by a lack of intestinal beta-defensin induction and recombinant hBD-2 represents a potential novel therapeutic strategy to counterbalance endogenous hBD-2 deficiency.
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PMC11569208
Pseudo alignment and transcript quantification were performed with KALLISTO, and differential expression was determined using SLEUTH.
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PMC9509578
Wang et al. developed a glucosamine-grafted and doxorubicin-loaded hybrid nanosystem that interacted with GLUT1 receptors to enhance targeted receptor-mediated endocytosis in MCF-7 and MCF-7/ADR cells and tumor bearing nude xenograft mice.
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PMC7039683
Is SNP2 the orofacial-cleft (OFC)-associated SNP at this locus that directly affects risk for the disorder?
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PMC10218459
The combination treatment CPP with cytostatic (both drugs) led to a significantly increased caspase 3/7 signal after 48 h treatments (Figure 6A,E).
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PMC11544771
Group variability and interaction were compared using Student’s t-test or one-way ANOVA followed by Bonferroni’s post-tests to compare replicate means.
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PMC8336407
unit of measurement = µM) t: tert-Butyl hydroperoxide (t-BHP) E: Pyrus biossieriana Buhse leaves extract t 100 (t-BHP, concentration: 100 µM), t 150 (t-BHP, concentration: 150 µM), t 200 (t-BHP, concentration: 200 µM) The effect of pyrus biossieriana buhse leaf extract and t-BHP treatment on antioxidant capacity in HepG2 cell line The experiment was repeated five times and the average is reported with standard error for each group.
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PMC11694066
Surface plots: the x-axis and y-axis values indicate drug concentrations, and the z-axis values indicate the associated synergy score; score < −10, antagonistic interaction; score = 0, absence of interaction; score > 10, synergistic interaction.
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PMC11354225
It was observed that the presence of EGCG at low concentrations (<50 µM) did not produce significant levels of ROS on A-431 cells; even so, a slight tendency of increasing ROS intensity (a.u.)
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PMC11764090
Physical interactions with other key regulatory proteins, formation of heterodimers with other transcription factors, and the ability to activate or repress gene expression in response to multiple signals can contribute to the diverse regulatory roles of MYC2 .
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PMC10877303
The top three potential candidates interacted with several active site residues in the targeted protein, including Cys145, Met168, Glu169, Ala171, and Gln192.
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PMC11658074
To investigate whether AT-EVs are the mechanism by which AT exerts its protective effects, we used nude mice, as shown in Fig. 2a.
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PMC11361748
Neutrophils rarely occur in healthy skin, but readily infiltrate when skin and other tissues are subjected to environmental stresses, and in various inflammatory skin disorders including PSOR , HS , and cancer .
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PMC11549062
Quantitative analysis of confined and directed modes of endosome and lysosome. (
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PMC10656496
Data recovered after 72 h of drug treatment with plotted points representing the mean FA for four technical replicates.
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PMC11502327
Not only that, the annual “economic toxicity” of OC is also devastating, costing more than $5.8 billion annually in the United States alone (2).
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PMC10391797
Combination therapy prolonged the overall survival of mice when compared with single CD123 CAR-T cell therapy (median survival: 180 days vs. unfollowed).
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PMC11742670
However, very few research using AI in the drug repurposing process has been conducted .
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PMC11711345
p-Cymene induced antiproliferation on B16-F10 (murine melanoma, IC50 of 20.06 µg/ml) and MCF-7 (human breast adenocarcinoma, IC50 of 5.11 mM) lines ; the suppression of 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced MMP-9 expression via the inhibition of the ERK1/2 and p38 MAPK signaling pathways in HT-1080 (epithelial fibrosarcoma) lines; and the inhibition (87% at 600 μM) of the invasive activity of these cells at the basal level .
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PMC11766332
We highlighted ASD-associated miRNAs reported in two or more studies.
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PMC8984067
An X-ray diffractometer was used to record the XRD patterns to characterize the phase of the materials, using Cu Kα (λ = 1.54056 Å) as the radiation source at a functional voltage of 40 kV, a functional current of 100 mA, a scanning rate of 8°/min, and a step size of 0.02°.
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PMC10522430
The plate, enveloped in aluminum foil, was relegated to an obscure setting overnight.
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PMC9219615
Approximately 20,000 cell events were obtained and analyzed per sample, and data analysis was achieved as mentioned in the cytometric analyses described above.
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