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OTAR3088
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BioData-CellLine_annotated

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PMC11082662
By regulating relevant signaling pathways, SMPDL3B can significantly promote the malignant transformation of ovarian cancer cells, thereby accelerating tumor development.
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PMC2118063
Positives were confirmed by sequencing.
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PMC9688728
However, the piecewise annotation of the object under study and the lack of understanding of the influence of the passage number on metabolomic patterns may confuse the researchers.
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PMC11786156
Although CD54 has been shown to be involved in cell-to-cell adhesion and proliferation of B-cell lymphoma cell lines, the clinical significance of its expression has not yet been elucidated.
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PMC8777939
Data are presented as mean ± SEM.
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PMC9429973
Regarding NRM, a non-significant increase in non-leukemic deaths were observed in colonized patients compared to non-colonized patients: 15% (7/46) vs 8% (4/46) P= 0.6.
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PMC11604015
However, these healthy donor-derived CAR-T cells need to be personalized, depending on HLA matching.
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PMC11267830
f Flow cytometry analysis revealed the proportion of human CD45-positive cells in mouse tissues.
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PMC9429973
The age at diagnosis ranged between 12 to 75 years with median age at diagnosis being 42 years.
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PMC11489351
Comparing the Persi results to our expression data, we found that a subset of genes such as CA9, glucose-6-phosphate isomerase, and PGK1 are similarly regulated at the transcriptional level in our dataset and at the enzymatic activity level in their dataset (Table S8).
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PMC11317131
Eluted products were pooled in equimolar amounts and were submitted to the UC Davis DNA Technologies and Expression Analysis Core lab for a second round of PCR (PCR2) and amplicon sequencing.
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PMC8839885
Our current research findings demonstrated that chemoresistance promoted by direct co-culture of OC with MSC cells might be reversed by 2HE2 and dasatinib, similar to results previously reported with fisetin.
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PMC11343332
The cytotoxic and pro-apoptotic potential of pycnogenol on the MCF-7 carcinoma of the breast cell line Various concentrations (20-120 µg/ml) were applied to the cells for a total of 24 hours.
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PMC11509224
Compounds 1 and 2 showed cytotoxic activities against HCT-116 cells, with IC50 (50% inhibitory concentration) values of 6.31 and 8.99 µM, respectively (Table 1).
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PMC11723210
The recent development of computational microscopy technology provides new opportunities for high-resolution QPI over a large FOV, synthetic-aperture interference microscopy , Fourier ptychographic microscopy (FPM) , transport of intensity equation (TIE) , differential phase contrast (DPC) , and lens-free on-chip microscopy (LFOCM) .
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PMC8984067
Scanning range was 650–4000 cm, and the resolution was 4 cm.
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PMC8164677
The results show that the combination was nearly additive (for more details interested readers may consult reference 24 where explanation is provided in supplementary Table 1) for all the sequences of administration in cisplatin-resistant cell line A2780.
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PMC2193049
Upon annealing, the fragments were inserted between the SacII–AvaI sites of pGFP/Ub, resulting in the plasmids pGFP/Ub–MAGE-3271–279 (Fig. 1, construct II), pGFP/Ub– MAGE-3256–279 (construct III), and pGFP/Ub–MAGE-3271–285 (construct IV).
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PMC11306019
Kim and team studied the antagonistic effects of 13 polyphenols, including one tannin, EGCG, GA, CA, RH, and eight flavonoids (Kim et al., 2009).
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PMC11747467
In our study, we observed that patients exhibited different clinical outcomes across consensus subtypes, sparking our interest in investigating the underlying mechanisms and potential drugs based on different molecule subtypes.
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PMC11538390
In silico transcription factor binding activities at the risk variant site were determined using HOMER and the Transcription factor Affinity Prediction (TRAP) tool.
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PMC11528603
The cell density was determined using MTT assay and the cell morphology was observed by Nikon Eclipse TiU microscope system (Nikon, Japan) at different incubation times (0, 24, 48, 72 and 96-hour time points).
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PMC11525028
Extra sum-of-squares F test.
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PMC9429973
Methods: MyPal aspires to empower patients and their caregivers to more accurately capture their symptoms/conditions, communicate them in a seamless and effective way to their healthcare providers (HCPs); and, ultimately, to foster action through advanced methods of identification of important deviations relevant to the patient’s state and QoL. To this end, MyPal developed a technical platform including a mobile app for patients with CLL and MDS, collecting information via standardized questionnaires and other information sources (e.g., wearable sensors), also enabling spontaneous symptoms reporting, educational material provision, motivational messages, discussion guides, notifications etc.
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PMC8010066
The cycling parameters included one denaturing cycle at 94 °C for 15 minutes, followed by 40 three-step amplification cycles (95 °C/30 s, 59 °C/30 s, and 72 °C/30 s).
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PMC11680049
The data on the localization of phenolic compounds in callus tissues in the zone of morphogenesis deserve special attention (Figure 9).
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PMC11194678
Membranes were washed three times with TBST buffer; incubated with horseradish peroxidase-conjugated goat anti-mouse antibody (1:4,000, Cat# AS003, RRID:AB_2769851; ABclonal), horseradish peroxidase-conjugated goat anti-rabbit antibody (1:4,000, Cat# AS014, RRID:AB_2769854; ABclonal), and then visualized on a LAS3000 Chemiluminescence Imaging System.
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PMC11499381
A limitation of our cAMP signaling work is that results were generated using end-point assays at a single time point (15 min stimulation).
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PMC11683240
Lacking lysine residues, PTS1 is safeguarded from ubiquitin-dependent degradation by the proteasome (22, 23, 24).
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PMC11413393
c Quantification of nuclear R-loops via immunostaining with the anti-RNA-DNA hybrid S9.6 monoclonal antibody in indicated cell lines and conditions.
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PMC11247842
Furthermore, it showed up as the key variant to drive the enrichment of liver active elements and promoters .
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PMC6487404
Each experiment was repeated three times and REG concentration was determined by the HPLC system.
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PMC10914904
After DICER-mediated processing, vtRNAs undergo fragmentation into small vault RNAs (svtRNAs), which are approximately 22–24 nt in length and can integrate into the Argonaute RISC Catalytic Component 2 (AGO2) protein.
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PMC11761919
The effects of inulin and PINs on the growth of recombinant E. faecalis.
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PMC9429973
Time-dependent area under the receiver-operator characteristic curves (AUROC), calibration plots and decision curve analyses (DCAs) were used to evaluate predictive accuracy.
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PMC5810978
The sample was diluted 10-fold in Dulbecco’s phosphate-buffered saline without Mg and Ca [PBS (-), Sigma, St. Louis, MO], vortexed briefly, and centrifuged at 4,000 × g at 4°C for 30 min.
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PMC10728535
Cisplatin‐resistant and ‐sensitive ovarian cancer groups were compared with find genes with significant expression changes using linear regression models in the LIMMA R package.
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PMC7602170
It is a calcium-dependent receptor-activated chloride ion channel protein, and provides a good sensitivity and specificity in the diagnosis of GISTs.
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PMC11753435
All peptide sequences evaluated in this study can be found in tables S1 and S2.
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PMC11720808
Dimethyl sulfoxide (DMSO) was obtained from Sigma-Aldrich (St. Louis, MO, USA).
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PMC10958426
We used UMAPCNV in slingshot to calculate pseudotime of tumor subclones in CRC#1.
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PMC11769516
Chemical CPT is an indole tretraminic acid.
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PMC9429973
In this study we report a subgroup analysis for hematology wards in university medical centers.
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PMC10291556
Electrochemical measurements were performed using an Autolab PGSTAT 302, Metrohm.
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PMC11723947
However, how conventional T cells integrate and interpret these signals at the level of chromatin still remains largely unknown.
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PMC9784246
A source temperature of 150 °C and high purity nitrogen as a sheath and auxiliary gas at a flow rate of 80 and 40 (arbitrary units), respectively.
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PMC9429973
Image: Summary/Conclusion: Palbociclib demonstrated in vivo AML suppression that was comparable to venetoclax and superior to chemotherapy.
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PMC8956657
A list of hydrogen-bonded interactions is presented in Supplementary Table 5.
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PMC11496728
Based on the abovementioned research background, this project optimizes a novel CHO cell expression system by optimizing the vector and establishing an Apaf1 knockout CHO cell line.
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PMC11761919
Following centrifugation (15,000 rpm, 30 min), the precipitate was resuspended in 1 mL of PBS (pH 6.8) and left stationary for 15 min.
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PMC9429973
Cidofovir was started when blood ADV-DNA was > 1000 copies/mL in symptomatic patients.
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PMC9429973
M. Ladetto, R. Tavarozzi, A. Evangelista, M. Zanni, A. Tucci, A. Anastasia, B. Botto, C. Boccomini, S. Bolis, S. Volpetti, V. R. Zilioli, B. Puccini, A. Arcari, V. Pavone, G. Gaidano, P. Corradini, M. Tani, S. Ferrero, F. Cavallo, G. Milone, C. Ghiggi, A. Pinto, D. Pastore, A. J. Ferreri, G. Latte, C. Patti, F. Re, L. Arcaini, F. Benedetti, S. V. Usai, S. Luminari, D. Mannina, A. Pulsoni, C. Stelitano, E. Pennese, G. Pietrantuono, F. Gherlinzoni, F. Pomponi, A. Olivieri, T. Perrone, D. Rota Scalabrini, C. Califano, B. Falini, G. Ciccone, U. Vitolo Department of Translational Medicine, University of Eastern Piedmont, Novara; Unit of Clinical Epidemiology, A.O.U. Città della Salute e della Scienza, Torino; SCDU of Hematology, AO SS Antonio e Biagio e Cesare Arrigo, Alessandria; Hematology, ASST Spedali Civili, Brescia; Hematology, A.O.U. Città della Salute e della Scienza; Hematology, A. O. U. Città della Salute e della Scienza, Torino; Hematology Department, ASST San Gerardo University Hospital, Monza; Institute of Hematology, University and Hospital of Udine, Udine; ASST Grande, Ospedale Metropolitano Niguarda, Milano; Hematology Department, AOU Careggi, Firenze; Hematology, Ospedale Guglielmo da Saliceto, Piacenza; Hematology, Card.
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PMC7154001
Several factors were shown to influence metabolite formation of the parent drugs/compounds with anticancer activities.
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PMC11291490
Which deposits the DNA in the intracellular space rather than inside the cell.
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PMC11536589
The nude mice were subcutaneously implanted with 1 × 10 AsPC1-MR cells.
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PMC11222184
In neurons, the apoptotic process was identified through a CASP2-dependent pathway, and a CASP9-dependent pathway was suppressed by endogenous inhibitors of apoptosis proteins .
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PMC6487404
Further studies are needed to fully characterize the possible interaction of REG with efflux transporters or CYP enzymes located in the small intestinal epithelial cells.
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PMC10452486
Furthermore, it was confirmed that the 38 kDa molecule expressed on the surface of the leukemia cells is non-covalently associated with B2m-free HLA–HCs, detected by mAb AI.4.
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PMC11637284
However, while the spindle filaments consist of MTs, the filaments of the TAC are much smaller, consisting of a single protein (p197) in the cytosol [14–16] and the protein pair (p166/TAC102) in the mitochondrial matrix [17–19].
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PMC9429973
Z. Li, X. Yin, C. Lyu, S. Cui, J. Wang, Y. Si, R. Xu Shandong University of Traditional Chinese Medicine; Shandong University of Traditional Chinese Medicine Affiliated Hospital, Jinan, China Background: Human multiple myeloma (MM) is a malignant and incurable B cell tumor.
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PMC11476837
Indeed, K67 specifically overcame sorafenib resistance in HCC cells without an impact on drug-sensitive hepatocellular carcinoma cells (HCC) after 72 h incubation .
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PMC10761571
Furthermore, down-regulation of the expression of Akt and up-regulation of the expression of BAX/BCL-2 have been associated with the inhibitory effect of gingerol on cancer cells .
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PMC11366496
Moreover, GSEA revealed that RNF122 was significantly correlated to JAK/STAT signaling (Figure S3B).
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PMC9105697
DNA fragments were individually tagged with a unique molecular identifier (UMI) at the 5′ and 3′ end.
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PMC11489351
We found that Notch1 expression in MDCK cells is significantly increased at high pHi and significantly decreased at low pHi compared to control (Fig. S5, E and F).
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PMC11704135
Pyrimidine derivatives have shown promising antimicrobial effects against a wide range of bacteria, including both Gram-positive and Gram-negative strains.
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PMC11750712
The sample was then transferred to a TruCount Tube (BD Biosciences) for acquisition and analysis on the BD FACSLyric (BD Biosciences).
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PMC11519583
To induce muscle injury and IMAT accumulation, Ctx (Latoxan, Valence, France) or glycerol (Nacalai Tesque, Kyoto, Japan) was injected into skeletal muscle .
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PMC11612508
The strong positive zeta potential suggested that the electrostatic repulsion between particles prevented aggregation and promoted stability.
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PMC10955424
Roman Korobochka: Writing – review & editing, Resources.
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PMC11506827
no. sc-8411), Bax (cat.
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PMC11085211
Indeed, imatinib-resistant subclones escape through alternative pathways that are not targetable from multi-target TKIs, suggesting that a TKI-based approach alone may not represent the only or best option for GIST patients .
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PMC10452486
Furthermore, the expression levels of Face-2 correlated with the levels of activation as determined by the IL-2R expression.
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PMC11752740
Our analysis confirmed significant modulation of MDR1, MRP1, NF-κB p65, and Caspase3 levels-key genes involved in drug resistance and apoptosis.
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PMC11371747
PCFT and RFC mRNA expression in colon cancer cell lines.
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PMC10577955
The plant experiments were performed in accordance with relevant guidelines and regulations.
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PMC11761919
The expression of the Fiber2 protein in E. faecalis was detected using western blot analysis.
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PMC11707832
Moreover, primary tumours exhibited markedly higher α-mannosidase activity than metastatic tumours.
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PMC9429973
The median time to onset of CRS was six days (range 1, 12) with a median duration of 5 days (range 2, 30).
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PMC11792740
This deterioration may be related to the diminished antitumor function of depleted T cells, immune surveillance evasion by tumor cells, and the influence of other immunosuppressive factors in the TME . (
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PMC9429973
Ravulizumab (RAV) is engineered from ECU with the main advantage of having an extended 8-week (vs 2-week with ECU) dosing interval, which decreases treatment burden markedly.
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PMC11021472
The percentage of GFP cells was followed post-transfection for three weeks and the GFP percentage was normalized to day 4 after transfection.
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PMC11705901
Recent research has shown that variations in OXT function are associated with individual differences in complex psychological and social functioning in humans .
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PMC11411131
The efficiency of this sensor could be improved by low-dose plasmid transfection (×0.1 DNA), compensating for the weaker signal intensity.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC9429973
R-mNHL-BFM-90 program is highly effective in de novo DLBCL NOS adult patients.
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PMC8526701
D GIST-T1 cells were treated with GSK602 at indicated concentrations for 24 h. The expression of PUMA was analyzed by western blotting.
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PMC9250505
Treatment of CAOV-2 cells with NPB enhanced the interaction of BAD with BCL-2, BCL-XL, or BCL-W as observed by co-immunoprecipitation (co-IP) assays (Supplementary Fig. 5D).
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PMC11194678
STAU is highly conserved during evolution, and two mammalian orthologs, STAU1 and STAU2, have been identified, which form distinct ribonucleoprotein particles (RNPs) and regulate different physiological pathways (Furic et al., 2008; Lebeau et al., 2008).
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PMC11705630
They showed that overexpression of GLDC suppressed proliferation, migration, and invasion of RCC 38-40.
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PMC9429973
Important differences were also found between the groups in the studied RBCs metabolic parameters.
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PMC10631132
Cells derived from the MB protocol did not give rise to osteoclasts.
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PMC9429973
We present a retrospective, multicenter, real-world data study consisting of 71 R/R DLBCL patients treated with Pola-BR in the named patient program in Turkey.
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PMC10178190
Various membranes were incubated with CM collected from HS-5 and TA-HS-5.
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PMC11591052
Increasing the intensity of anabolism requires the coordinated up-regulation of a number of biosynthetic processes, for which glycolysis and one-carbon metabolism are crucial sources of structural units .
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PMC9429973
F. Auer, A. Escudero, M. Sipola, A. Viitasalo, M. Morcos, U. A. Friedrich, A. Pandyra, A. Borkhardt, M. Takagi, J. Hauer Department of Pediatrics, Technical University Munich, Munich, Germany; Institute of Medical and Molecular Genetics (INGEMM) La Paz University Hospital, Madrid, Spain; Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland; Pediatric Hematology and Oncology, Department of Pediatrics, University Hospital “Carl Gustav Carus”, TU Dresden, Dresden; Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich-Heine University Duesseldorf, Medical Faculty, Duesseldorf, Germany; Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan Background: Somatic mutations affecting the PAX5 gene are common in pediatric B-cell acute lymphoblastic leukemia (B-ALL).
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PMC11628904
An attractive hypothesis is that aberrant keratinocyte damage signalling promotes chronic inflammation, a process thought to contribute to burn wound conversion in human patients.
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PMC9024365
A clustering of GluA2 by SD1 requires a 37C incubation after the surface labeling at 4C (Kalashnikova et al., 2010).
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PMC11546117
The transcriptional profile of drug transporters showed a differential level of gene expression (Figure 4), ranging from ΔCt values that were very negative (lower expression) to ΔCt values that were less negative (higher expression).
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PMC3019555
Cells were fixed with PHEMO buffer (0.068 M Pipes, 0.025 M Hepes, 0.015 M EGTA, 0.003 M MgCl2, and 10% DMSO, pH 6.8) containing 3.7% formaldehyde, 0.05% glutaraldehyde, and 0.5% Triton X-100 for 10 min at room temperature.
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PMC11088135
A qRT-PCR was used to determine the expression level of lncRNA NUTM2A-AS1 in glioma cell lines.
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