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OTAR3088
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BioData-CellLine_annotated

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PMC11371747
Intact cells will readily internalize radioactively labelled [5-H]-deoxycytidine, which will be rapidly converted by deoxycytidine kinase (dCK) to [5-H]-dCMP and subsequently deaminated to [5-H]-dUMP, which will then serve as a substrate in the TS catalysed reaction to dTMP and H2O; the quantity of H2O formed over time is a measure of intracellular TS activity.
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PMC8540692
In this regard, the combination treatment of CCM and NaBu was actively arresting the cell cycle in the G2/M phase in all cell lines, while single compounds were active in two out of three analyzed cell lines, i.e., T98G and U-138 MG cells.
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PMC11696576
Both MafG and Nrf1 are known to cooperate with Nrf2 to regulate the expression of antioxidant response genes, while Hes2 is a little studied member of the Hes family of transcription repressors downstream of Notch.
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PMC8913139
The above results suggest that miR-448 reduces ROCK1 expression by binding to its 3′-UTR.
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PMC11682172
The passage of MDA-MB-231-B2M2 cells was less than for MDA-MB-231 and SK-BR-7.
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PMC11190538
The amide II band is primarily N–H bending, contributing from C–N stretching vibrations.
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PMC8873393
Compared to mRNAs, annotated lncRNAs also exhibited low mobility in that the UV-dependent changes in cellular distribution were only observed in 4.4% of annotated lncRNAs (cluster 4 in Fig. 5C, D).
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PMC11743975
The plate was incubated at room temperature for 10 min before record luminescence.
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PMC11033180
Western blot for phosphorylated CaMKII at Tyr286 (A), phosphorylated ERK at Thr202/Tyr204 (B), and synapsin 1 at Ser-603 (C).
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PMC11612626
In addition, we also observed that compound A treatment increased the representation of Tyr or Phe as the terminal amino acid of the most upregulated peptides to suggest that compound A directly modulates the immunoproteasomal cleavage pattern.
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PMC9919300
Furthermore, the data from cell viability, lipid content, ROS production, and gene expression analyses evidenced that the effect of the association on lipids was mediated mainly by curcumin, while the cytoprotective effect was principally ascribable to andrographolide.
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PMC6182045
Yields were calculated by dividing protein recovered after each purification step to starting supernatant.
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PMC11394112
U2932 and primary DLBCL cells in the MISTRG mice engrafted with cord blood human hematopoietic stem (HSC) cells or non-engrafted MISTRG6 showed spleen infiltration .
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PMC9776316
To exclude the possibility of an off-target effect by RNAi screen, a sgRNA-based screen was also performed.
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PMC9776316
A significantly higher expression level of XRCC4 was observed in the primary ovarian cancer tumor samples from the resistant group than from the sensitive group (Figure 1e).
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PMC9985266
A RT‒qPCR for MEG3 transfection efficiency; B Western blot for ERK and p38 phosphorylated protein expression levels; C EdU for cell proliferation viability (magnification: × 200; scale bars: 100 μm); D Western blot for LC3 and Beclin1 protein level; E Immunofluorescence detection of LC3 and Beclin1 fluorescence intensity (magnification: × 200; scale bars: 10 μm); F–H RT‒qPCR detection of α-SMA, FN, and COL I mRNA expression level; I: Western blot detection of α-SMA, FN, and COL I protein expression level; J Immunofluorescence detection of α-SMA, FN, and COL I fluorescence intensity (magnification: × 200; scale bars: 100 μm). *
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PMC11201245
Signals are evaluated separately if they have a distance of at least one signal diameter between two signals.
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PMC11585994
As shown in Figure 3E, G5-sgc8-siBCL11B exhibited minimal impact on the viability of normal T cells, underscoring their relative safety.
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PMC11334037
The CCK-8 results showed that cell viability was significantly increased after exogenous expression of IGF2, sh-IGF2 transfection inhibited GIST882 and GIST-T1 cell viability (Figure 2C, P < 0.001).
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PMC6889484
For round 6, proviral DNA from cell cultures in which virus replication peaked (day 9) was analyzed for 75% CEM/D128K from 6 independent flasks a–f. Error bars represent SD.
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PMC11543853
Not all virus particles from the inoculum attached and entered into the cells.
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PMC6133382
The effect of differences in glycosylation was also examined on the binding of the VRC01 bN-mAb, known to recognize a glycan-independent epitope adjacent to the CD4 binding site .
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PMC11765988
A meta-analysis of studies conducted in Japan, the UK, the USA, and Scandinavia reported a pooled relative risk (RR) of 1.19 (95% CI, 1.07–1.32) for all invasive cancers .
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PMC10114490
The life span of human fibroblasts can be significantly expanded by hTERT expression .
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PMC11637276
Moreover, PP2A is activated downstream of α2β1 integrin in fibroblasts .
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PMC3765139
The tumorigenic potential of CSCs unites self-renewal and differentiation potential.
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PMC11024707
In the present study, the lowest expression levels were found in the patient (ASD) group and the highest expression levels in the control group and a difference close to statistical significance was observed (p = 0.058).
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PMC11424574
The shMTA2 (clone ID: TRCN0000232200) was purchased from the RNA Technology Platform and Gene Manipulation Core Facility (RNAi core) of the National Core Facility (Taipei, Taiwan).
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PMC11670954
The electrical resistance was subsequently measured three consecutive times.
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PMC10237474
The expression level is generally good if the titer of the virus stock is high.
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PMC11644761
Thus, assessing genome-wide DNA methylation in untreated, treated, and co-treated cells is a modern and valuable endpoint, especially when combined with treatments that alter neuronal cell cycle progression and viability.
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PMC9118379
In other words, the spectra in group 1, the majority of the 320 spectra, still matched the same variant peptide even when searching against the huge SuperPep_V database, and thus their identified variant peptides were high confidence.
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PMC11635087
Therefore, we speculated that introducing chloroplasts directly into animal cells without any modifications may be a cost-effective method for increasing energy production.
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PMC10849234
Eosinophil-like cells differentiated from HL-60 cells have also been used as a model to study degranulation in eosinophils [32, 41–43], lending further support to the utility of the HL-60 promyelocytic cell line in studies of granulocyte degranulation.
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PMC11392912
Briefly, 1 µg of total RNA was mixed with 1 µl Oligo dT primer and incubated at 60°C for 10 min.
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PMC4685411
Even if high throughput systems can handle these parameter combinations in parallel experiments, the heuristic restriction of boundaries can result in stepwise iterations with many experiments.
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PMC11746942
Scale bars: 100 μm.
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PMC5916734
PCR was performed using oligonucleotide primers and mixtures for the PCR Encyclo PCR kit, Tersus polymerase mix, and ScreenMix-HS (Evrogen, Russia) on a PTC-100 Thermal Cycler (MJ Research, USA).
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PMC10745221
In previous literature, multiple bands ranging from 25 kDa to 150 kDa are also shown in an anti-ADMA immunoblot of an HCT116 cell lysate .
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PMC11547972
One patient developed severe metabolic acidosis after ingesting amygdalin with a serum HCN level of 385 µg/dL .
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PMC11740508
10 mM stocks were made in DMSO.
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PMC8735881
The cells were then lysed and quantitated for luciferase expression as described above.
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PMC10213179
Internalization of fluorescent labeled aptamers (ATOP and SCR) into RH4 and A673 was measured by flow cytometry (MFI) and normalized against the SCR sequence. (
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PMC6114978
These three lines are indicated by an asterisk in part (A).
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PMC9429973
As seen with loss of STAT3-Y640F expression, loss of SBNO2 also impaired proliferation of transformed mHSPC.
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PMC8735881
Therefore, our studies provide new strategies for generating HIV-resistant cells, which can be used alone or with other gene therapy approaches.
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PMC6364197
It is very important for cells to maintain the initial phenotype and not differentiate with the prolongation of the cell culture.
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PMC11307990
To validate that DNA nanotapes adsorbed SUN, DNA nanotapes were incubated with SUN and purified, and then the absorbance of the sample was measured with a UV–visible spectrophotometer (Figure 2D).
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PMC11297139
Furthermore, intracellular ARID1A condensates were dissolved significantly upon the treatment of 1,6-hexanediol—compound that disrupts weak hydrophobic interactions (Fig. 1d).
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PMC11739484
This highlights the potential role of these MMPs in driving therapeutic resistance.
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PMC10887351
Pharmacological activation of β3-ARs in BAT and WAT in mice models inactivated both thermogenesis and de novo lipolysis .
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PMC8389560
It was found that inhibition of Cx43 leads to a significant suppression of the induction of apoptosis in these cells after 24 h treatment of cells with selenium nanoparticles at a concentration of 5 µg/mL.Apoptosis is an important process of selective destruction of damaged or defective cells in the process of vital activity and a violation of this process can lead to the development of cancer .
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PMC11502443
Therefore, BSA likely caused a conserved reduction in trizeaptide potency (pEC50) compared to GIP across all signalling molecules tested.
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PMC9429973
Regarding MDS, no significant difference in OS was found between patients with low (<2.0) and high NLR (≥2.0).
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PMC11670954
A P-value of less than 0.05 was considered to indicate statistical significance.
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PMC8540692
In respect to NaBu, the tested range of concentrations gradually decreased the viability of GBM cells.
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PMC8750422
To investigate the mechanism by which GPR87 promotes lung adenocarcinoma cell progression and metastatic ability, a human phospho-kinase array was performed using A549 lung adenocarcinoma cells.
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PMC10988808
Apoptosis experiments showed that overexpression of CCDC25 promoted apoptosis of renal carcinoma cell lines (Fig. 2F).
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PMC11656380
human T-ALL cell lines, (B) myeloid leukemia and lymphoma cell lines, and normal primary human mononuclear cells. (
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PMC7171147
N = 3; y-axis, relative mRNA expression (fold change); error bars, SD; *p < 0.05; **p < 0.01.
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PMC9429973
Its efficacy was not optimal which might be due to lack of its effect on new variations of virus.
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PMC11545868
Fas, also known as CD95 or APO-1, is a cell surface receptor protein that plays an important role in the process of programmed cell death.
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PMC10933092
Therefore, the four mRNAs that had prognostic value for patients with BLCA were examined and survival analysis was performed based on the expression of the eight mA methylation-driven mRNAs from the TCGA database.
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PMC7153288
For flow cytometry analysis, 1.5 × 10 of A549 cell was seeded in each well of a 6-well plate containing 5 ml of DMEM supplemented with 10% FBS and the plate was incubated for 48 h. Then, the medium was replaced by 3 ml of fresh medium containing 0%, 1.25% and 2.5% (v/v) of the Streptomyces sp. SS1-1 culture broth and the plate was incubated for 24 h. Cells were detached from the plate and stained with PE Annexin V and 7-AAD (Apoptosis detection kit, BD) before cell apoptosis was detected by flow cytometry.
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PMC11684269
Lipid dysregulation involves multiple processes, including fatty acid metabolism, cholesterol metabolism, and lipid droplet deposition, and the primary structural units affected are the renal tubular epithelial cells and podocytes (85, 94).
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PMC9454852
Altered ER homeostasis due to a shifted redox state leads to a pro-apoptotic condition.
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PMC9919300
In our experiments, the downregulation of genes involved in lipid/cholesterol metabolism and transport (such as FABP1, APOC3, PPARGC1A, GK, ABCA1, and SRBF2) induced by curcumin treatment could explain the observed reduction of steatosis and lipid content.
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PMC11522251
Significantly, by blocking STAT3 signaling, HOXB8 silencing was able to increase the inhibitory impact of cetuximab in colorectal cancer cells, indicating a crucial role for HOXB8 in primary drug-resistant colorectal cancer cells.
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PMC11627133
White frames indicate the region of interest, depicted as zoom‐in.
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PMC11625890
Neurodegenerative diseases affect millions of people worldwide.
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PMC4277423
Since TZM.bl cells are originally derived from HeLa cells co-transduced with retroviral vectors expressing human CD4 and CCR5 transgenes as well as HIV-1 LTR-driven reporter genes , the genome of TZM.bl cells contains both endogenous CCR5 alleles and an integrated CCR5 transgene sequence.
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PMC11496728
The two expression vectors pCMV-eGFP-1 and pCMV-eGFP-2 (Fig. S1A–C) were successfully constructed using pCMV-eGFP-F2A-RFP as the backbone vector (pCMV-eGFP), and the Kozak sequence and combined sequence of Kozak and Leader were added upstream of eGFP, which were further confirmed by sequencing.
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PMC7039683
Statistical significance was determined using the Student’s t-test.
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PMC9429973
Secondary PK endpoints included AUC from time 0 to the time of the last observed quantifiable concentration (AUClast) and maximum observed concentration (Cmax).
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PMC11705630
The level of intracellular ROS was measured with mitoSOX (Thermo Fisher, MA, USA) staining according to the manufacturer's instruction.
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PMC11545737
This inflammasome is expressed mainly in immune cells, such as macrophages, cytokine-activated monocytes and granulocytes but also in serosal and synovial fibroblasts .
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PMC8358006
GO term analysis of the GSD-targeted genes indicated enrichment of terms related to development and differentiation processes.
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PMC9592219
The first-strand cDNA of miRNA TransScript SuperMix (TransGen Biotech, China) was used for the synthesis of miRNA cDNA.
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PMC8427838
Cell lysates derived from RKO cells expressing empty vector or TMIGD1 were blotted for TMIGD1 and protein loading control, GAPDH.
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PMC11806818
GP73 was detected by measuring the UV absorption peak at 652 nm.
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PMC9429973
Aims: This study i had two i main objectives: i to determine seroprevalence i of HBV, HCV, HIV and syphilis in i blood i donors of i Boufarik i post transfusion and to study i sociodemographic i factors of blood donors.
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PMC9429973
Primary endpoints are safety, based on adverse events (AEs), and efficacy of mitapivat treatment based on RBC sickling assessed as the Point of Sickling (PoS) using oxygen gradient ektacytometry.
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PMC11098378
Using mutagenesis, we demonstrate the importance of diverse enzymatic functions for SopB, IpgD, HopAM1, and IpaH4 in breaking arbovirus restriction.
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PMC11806182
Fig. 2Survival analysis of tissue miRNAs in UCEC patients grouped by miR expression.
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PMC4443654
Regions occupying the active A nuclear compartment in one cell type, but the repressed B compartment in the other two, were selected and ranked by the number of predicted active enhancers (Figure 4). (
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PMC7433824
For example, it is not available in every country due to ethical concerns since it might be employed to abort a pregnancy in the late term.
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PMC4355729
The alteration of PI3K/AKT pathway has been found in a broad spectrum of cancers9.
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PMC10391797
The y-axis and x-axis of the heatmap correspond to T cell activation/inhibition genes and cancer-immunity cycle seven steps/immune cell infiltration, respectively.
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PMC9878562
Next, we addressed the role of the C-terminus of ACKR3 in promoting the migration of VAL-ko.
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PMC11320834
software (Illumina, CA, US) was manually reviewed according to the online databases ClinVar, dbSNP, and Cosmic.
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PMC11566417
n = 3.
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PMC11737091
In this study, we delve into the clinical significance and biological functions of DBF4 expression in ccRCC patients and cell lines, aiming to shed light on its potential role and therapeutic implications in this disease context.
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PMC2118063
Although IRF8 is also expressed in lymphocytes, its roles in B cell and T cell maturation or function are ill defined, and few transcriptional targets are known.
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PMC11637284
A kDNA area value of zero means the complete loss of the kDNA. (
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PMC9429973
Summary/Conclusion: The EMMY study shows that carfilzomib is used in many combinations in extended real-life settings compared to pivotal clinical trials including older patients, largely-exposed to lenalidomide and at advanced disease.
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PMC11188874
pAc-neo-Ova carries a complete copy of chicken OVA mRNA and the neomycin (G418) resistance gene.
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PMC9516401
Another study found that interleukin (IL)-6 increased IDE expression and activity (Kurauti et al., 2017 ▶).
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PMC11615743
We then conducted a triple‐aptamer‐based logic device test on living cell membranes using four cell lines, in which CEM demonstrated a triple‐positive recognition pattern for Sgc8, TC01, and Sgc4f.
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PMC11721096
Among them, CD8TM serves as the transporter of hTYR to the cell surface, while the CD8hinge functions as a “stalk” that anchors hTYR on the cell surface .
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PMC10547921
ADC drugs have undergone three generations of innovation, driven by increasingly mature technologies (Fig. 2).
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