OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC10870498	HEK-293T cells were treated with actinomycin D (ACD, 0.5 µg/mL, Sigma), then existing KIF23 expression was detected at different time point (0, 6, 12, and 24 h) using qPCR.	[ { "tags": [ "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC11472569	Inhibition of miR-301b-3p or upregulation of TXNIP increased the chemosensitivity of DDP/VCR-resistant gastric cancer cells and reversed malignant behaviors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Inhibition", "of", "miR-301b-3p", ...
PMC9429973	The venous TE encompassed deep vein thrombosis (DVT, 40%), and Budd-Chiari syndrome (10%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "venous", "...
PMC11335267	p < 0.05; p < 0.01, *p < 0.001; Student’s t-test We hypothesized that the observed effects in Alx3-deficient mice could be related to decreased sympathetic input regulating motor innervation at the neuromuscular junction .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11782780	However, the regulatory role of EBF3 in BC cell stem-like phenotype still requires further investigation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "the", "regulatory", "role", "of", ...
PMC9429973	Early response was defined as an increased platelets response at 1 week. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Early", "response", "was", "defined", "as", "an", "increased", "platelets",...
PMC11657695	A-673/TR/shEF RNA-Seq data without induction (Day 0) and with induction of shRNA targeting EWS::FLI1 (Day 7) came from the Gene Expression Omnibus database (GEO) GSE164373 .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Thrombosis events (TE) were reported in 33% of patients prior to treatment start (n=42) and 3 (7%) had thrombosis during FU of which 2 patients had no prior history of TE.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5925824	LY3300054 single agent treatment induced gene expression changes indicative of immune activation, exemplified by increased expression of IFNG, IL2, IDO1, GZMB, IL1B, IL6, while ipilimumab single agent treatment resulted in enhanced T cell activation, exemplified by enhanced ICOS, and IFNG accompanied by downregulation of myeloid genes (CD68, CD14, HLA-DRA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11344246	RNA was extracted from cell lines and organoids using TRIzol (Invitrogen) according to the manufacturer's instructions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "RNA", "was", "extracted", "from",...
PMC11711935	Soluble SCF can activate epidermal melanocytes by diffusing to the epidermis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Soluble", "SCF", "can", "activate", "epidermal", "melanocytes", "by", "diffusing", "to", ...
PMC10887351	While it is known that β2-ARs play a crucial role in BC, Montoya et al. showed that β1- and β3-ARs proteins in BC tissue are expressed more than in the normal mammary epithelium .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8708099	Surprisingly, our results showed that osthole has a higher potential than FXF to decrease the histamine-induced secretion of pro-inflammatory CKs, thus FXF should not be considered as a positive control in this experiment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11740573	Moreover, it has been demonstrated that calcitriol reduces the production of pro-inflammatory cytokines, such as TNF-α, INF-γ, IL-6, or IL-1, while increasing anti-inflammatory cytokines such as IL-10 .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11673128	These pathways, also known as “don’t eat me” signals (DEMs), have been validated in both solid and blood malignancies, fostering immune evasion and cancer survival .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The genetic loci used in the prediction included BCL11A but also included NOS1 and ARG2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "genetic", "loci", "used", "in", "the", "prediction",...
PMC11754094	P values were calculated using Mann–Whitney tests.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "P", "values", "were", "calculated", "using", "Mann", "–", "Whitney", "tests", "." ] } ]
PMC7433824	Hence, the enhancement of this protein may also increase the antigenicity of GBM cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hence", ",", "the", "enhancement", "of", "this", "protein",...
PMC9429973	In vivo deletion of Sucnr1 from Nestin stromal cells promoted expansion of long-term HSC (LT-HSC) versus intact recipients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "vivo", "deletion", ...
PMC11611077	Transient current Q, current decay τ and total resistance Rt were continuously calculated by the software at a resolution of 25 Hz, by averaging the responses to 10 positive and 10 negative consecutive test steps, and measured values for these parameters were stored in the computer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11345828	All NMR spectra were recorded at room temperature on a 400 MHz AMX Bruker spectrometer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "NMR", "spectra", "were", "recorded", "at", "room", ...
PMC11363012	In cells derived from petals of the SA cultivar, the majority of cells sampled are highly enriched in either rutin (17) (flavonoid)/peonidin 3-O-rutinoside (19) (anthocyanin), the flavonoid mauritianin (16), or a combination of monoterpene indole alkaloids (Figure S17).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9920575	The procedure was conducted according to the methodology provided in the Caspase-8 Colorimetric Assay Kit (R&D Systems, Minneapolis, MN, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11724582	E-F) Cell invasion was measured via a Transwell invasion assay (magnification, ×100).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "E-F", ")", "Cell", "invasion", "was", "measured", ...
PMC11805741	Cells were seeded in 6-well plates and followed up until they formed a confluent monolayer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "seeded", "in", "6-well", "plates", "and", ...
PMC7961460	It is highly synthesized by the low metastatic cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "is", "highly", "synthesized", "by", "the", "low", "metastatic", "cells", "." ] } ]
PMC11740399	Lipo: liposome, Mem: tumor membranes, ML: cell membrane hybrid liposomes. *	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Lipo", ":", "liposome", ",", "Mem", ":", "tumor"...
PMC11537649	Furthermore, to confirm whether Lnc NEAT1 regulated CDK6 expression by sponging miR-152-3p, we simultaneously overexpressed Lnc NEAT1 and miR-152-3p in Hacat cells or simultaneously knocked down Lnc NEAT1 and miR-152-3p in A375 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellL...
PMC4355729	Since the pathway plays an important role in RCC pathogenesis2, it has been showing a great promise for molecularly targeted treatment of RCC69.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9014716	A and B) The viability of human hepatoma cells treated with PS-T was measured by CCK-8. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "and", "B", ")", "The", "via...
PMC11422497	Pearson’s correlation analysis showing a negative correlation between circ_SMA4 and miR-494-3p expression in GISTs tissues.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Pearson", "’s", "correlation", "analysis", ...
PMC5417661	Another factor that has overshadowed the therapeutic advancement is the fact that the origin and pathogenesis of OC remain poorly understood.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Another", "factor", ...
PMC11549612	To investigate expression differences among the BOLA family members, we first carried out RT-qPCR to assess the mRNA levels of each BOLA gene in KIRC cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", ...
PMC11525028	The protein concentrations were determined using the Pierce BCA Protein Assay Kit (ThermoFisher, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "protein", "concentrations", "were", "deter...
PMC10882807	Despite recent achievements in HCC treatment, its diagnosis and prognosis remain challenging .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Despite", "recent", "achievements", "in", "HCC", "treatment", ",", "its", ...
PMC10033453	However, adverse events were observed in the VMG-treated groups that were not dose dependent, with one mouse found moribund on day 6, and 6 out of 20 VMG-treated mice found dead after day 8 (Figure 3B; Table S3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7348793	Tandem repeats in mtDNA were identified using Tandem Repeat Finder .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Tandem", "repeats", "in", "mtDNA", "were", "identified", "using", "Tandem", "Repeat", "Finder", ...
PMC8345486	Luminescence measurements were then performed to determine the AP-1 and Nf-κB promoter expression levels (Figure 7E,F).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Luminescence", "measurements", ...
PMC8348645	DPPH (EEC No. 217-591-8, Sigma, St. Louis, MO, USA), stored at less than 0 °C, methanol, HPLC grade (Ranbaxy Chemicals) was used for the DPPH analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11665555	Specifically, ketone metabolites like acetoacetate and βHB are associated with increased staging (21).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Specifically", ",", "ketone", "metabolites", "like", "...
PMC11297139	c Live-cell imaging of 293T cells expressing GFP-ARID1A.	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O" ], "tokens": [ "c", "Live-cell", "imaging", "of", "293", "T", "cells", "expressing", "GFP-ARID1A", "." ...
PMC10291556	We demonstrate the superior antiproliferative activity of the new Pt(IV) complexes containing DCF axial ligand(s) against a panel of cancer cell lines of various origins, particularly in the case of Pt(IV) complex 4 (containing two axial DCF ligands), which achieved comparable or even better activity than the parental Pt(II) complex 1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11499381	These interactions have all been probed with the split fluorescent proteins fused to the intracellular portion of the protein [2–5].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "int...
PMC11763111	This is probably because the patient's immune system rejects them because of HLA loss or mismatch, which makes them appear alien .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", ...
PMC11779960	T cells undergo sequential rearrangement of TCR V(D)J gene loci, starting with δ, followed by γ, β, and α (Fig. 1a).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Iron overload aggravated and iron restriction alleviated the formation of reactive oxygen species, accumulation of DNA damage and levels of the apoptosis marker annexin V in hematopoietic stem and progenitor cells (HSPCs).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11754432	Cytokine secretion from human skin equivalents (K–O) treated with cytokine cocktail with or without 10 µM ML351 for 6, 24 or 48 h (N = 5).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11391695	However, additional research is necessary to ascertain whether the treatment is more effective with the PEI/NPs encapsulating the vector coated with HCC cell membrane.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11767793	The toxicity of the post-centrifugation Au-PEI@NIST was evaluated and compared with the original particles using the CHO K1 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O" ], "tokens": [ "The", "toxicity", "of...
PMC11377827	Data was analysed with GraphPad Prism v.8.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "was", "analysed", "with", "GraphPad", "Prism", "v.8", "." ] } ]
PMC11564322	Data denoted as # are statistically different between certain groups at p < 0.05 After the 48-h exposure of the K562 cells to the VVGPGA peptide, an 18.98% decrease in the AKT kinase expression was observed, compared to the control (Fig. 7B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", ...
PMC10999934	Clusters 2, 3, 8, 9, 10, 22 and 23, containing 10,003 cells, were epithelial cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Clusters", "...
PMC11365427	This study was supported by the Capital's Funds for Health Improvement and Research (CFH) (Nos. 2020-1-2031 and 2020-2-4082, China), and State Key Laboratory of Respiratory Health and Multimorbidity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11033180	Furthermore, Sema5A negatively regulates the spontaneous activity and the frequency of miniature post-synaptic currents of enteric neurons.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "Sema5A", "negatively", ...
PMC9111184	As a control we investigated the infrared response of untreated Caco-2 cell line (Fig. 1).Fig.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "a", "control", "we", "investigated", "t...
PMC9822769	The Pt content in the control experiment, which characterizes any possible Pt contamination during the overall process, was statistically insignificant with respect to the cellular Pt accumulated during treatment, even in the case of A2780cisR. Experiments with the inhibitors were carried out at 37°C as follows: (i) NaN3 + 2-deoxy-D-glucose (2DG): preincubation for 30 min in PBS with 25 mM NaN3 and 25 mM 2DG, followed by a 10 μM CT with the Pt compounds in Earle's Balanced Salt Solution (EBSS) for 1 h; (ii) cimetidine (CMT): coincubation with 1.5 mM CMT and 10 μM Pt compounds in EBSS for 1 h; (iii) 1-methyl-4-phenylpyridin-1-ium (MPP): coincubation with 2.0 mM MPP and 10 μM Pt compounds in EBSS for 1 h; (iv) cytochalasin D (CTD): preincubation for 30 min in EBSS with 10 μM CTD, followed by a 10 μM CT with the Pt compounds in EBSS for 1 h; (v) O-benzylserine (BS): coincubation with 1.0 mM BS and 10 μM Pt compounds in EBSS for 4 h; (vi) ouabain (OUA): preincubation for 1 h in EBSS with 1 mM OUA, followed by a 10 μM CT with the Pt compounds in EBSS for 4 h; (vii) tetraethylammonium chloride (TEA): preincubation for 1 h with 2.0 mM TEA followed by 10 μM Pt compounds in EBSS for 4 h. In the experiments at low temperature, A2780 cells were preincubated for 2 h at 4°C, followed by CT with each Pt compound (10 μM) for 4 h. In all cases, at the end of the CT, the cells were manipulated as described in the previous paragraphs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8623816	These results indicated that RsRV5 is evolutionarily related to members of the family Partitiviridae.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "results", "indicated", "that", "RsRV5", "is", "evolutionarily...
PMC11092382	Additional investigations into the interplay between sophocarpine and NF-κB in alternative pathological states are warranted.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additional", "investigations", "into", "the", "interplay", "betwe...
PMC11461833	The protein and mRNA expression levels of STXBP5 were then measured (Fig. 3C, E).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "protein", "and", "mRNA", "expression", ...
PMC9429973	Furthermore, Nachun et al. reported that the combined measure of Hannum and GrimAge acceleration modifies the effect of CHIP mutation status, resulting in strongly increased risk of all-cause mortality in individuals with both CHIP and accelerated Hannum age and GrimAge age.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10926885	The four malignancies in the TIMER2 database that had the strongest correlation with immune cell infiltration are shown in Figure 6C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "four", "ma...
PMC11155445	Inhibitory activity of the new N-acylated thiourea series (156a–u) was evaluated against O. minor radicle elongation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Inhibitory", "activity", "of...
PMC11180402	Nevertheless, the roles, mechanisms, and upstream regulator/downstream effectors of SNHG1 in human MIBC invasion and growth have rarely been explored.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Neverth...
PMC9429973	Algorithmic analysis is performed (R-script) for quality control (QC) and subtype determination and resulting data are verified by the pathologist and loaded directly into the EMR for correlation with clinical data and final diagnosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11770130	With single-cell RNA-sequencing (scRNA-seq) analysis, we have determined that NTS was also produced specifically by lymphatic endothelial cells (LECs) as an anti-thermogenic peptide in brown adipose tissues (BATs) and a pro-lipid absorption peptide regulating the development of atherosclerosis in intestines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Madrid; H.Universitario Virgen del Rocío, Sevilla; H.Vall d’Hebron, Barcelona; H. Universitario Cruces, Barakaldo, Spain Background: Acute myeloblastic leukemia (AML) usually presents with cytopenias, although its degree is variable and in some cases it is non-existent.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Statistical processing of the results was estimated by the value of p ˂ 0, 005.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Statistical", "processing", "of", "the", "results", "w...
PMC11449273	All biochemical experiments were repeated at least 3 times and the figures are representative of one typical experiment for each assay.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "biochemical", ...
PMC11297139	The reads were then assigned into 40 kb genomic bins to generate a 40 kb Hi-C contact map.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "reads", "were", "then", "assign...
PMC11464982	Controls received the vehicle (water for injection).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Controls", "received", "the", "vehicle", "(", "water", "for", "injection", ")", "." ] } ]
PMC11756907	The cell monolayer, after removing the culture medium, was washed with 0.9% NaCl.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "cell", "monolayer", ",", "after", "removing", ...
PMC10969097	The data were exported to the reference manager.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "data", "were", "exported", "to", "the", "reference", "manager", "." ] } ]
PMC9429973	There was no statistically significant difference in mortality between CD patients with and without IDA (Odds ratio (OR): 0.79; 95% confidence interval (CI): 0.595-1.049, P= 0.103).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10874773	Acetal-hemiacetal and/or ortholactone: This class of sesquiterpenes has been reported to be composed of unique acetal-hemiacetal and/or ortholactone structure, and it can be expected that they may be in equilibrium between acetal-hemiacetal and aldehydes or between normal esters and lactones (Fig. 7).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11453690	A. Zhang: None.	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "A.", "Zhang", ":", "None", "." ] } ]
PMC10530622	Post-translational modifications regulate its activity, namely N-glycosylation at amino acids 167 and 172 within the putative second extracellular loop, particularly its efficacy on oxalate transport, not influencing its plasma membrane delivery .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11756937	In summary, our study demonstrates that while the source material does not significantly impact reprogramming success rates, the SeV method is notably more effective than the episomal approach, providing crucial insights for the reliable and reproducible generation of high-quality hiPSCs in biobanking.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	C-MYC/BCL6 HGBL DH and HGBL NOS are more heterogenous and in some cases can be represented by transformation of MZL with paraprotein secretion.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "C-MYC/B...
PMC10547921	Chemical structures of IRDye700DX (128); (B) The mechanism of NIR-PIT ADC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Chemical", "structures", "of", "IRDye700DX", "(", "128...
PMC9429973	However, cases of ATE were noted at diagnosis (1 (5.6%) patient), after transplantation (1 (5.6%) patient) or at relapse (1 (5.6%) patient) as well.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Summary/Conclusion: Imbalances in MTHFR homocysteine metabolism associated with the polymorphisms do not appear to be a risk factor for ALL in the study cohort.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973	Mechanistically, we implied NOTCH1 signalling activation in Bcor loss mediated tumorigenesis with potential for targeted treatment for high-risk CLL and RT patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mechani...
PMC9429973	B. Vakrmanova, M. Novakova, P. Riha, M. Zaliova, E. Fronkova, E. Mejstrikova, L. Reznickova Rezkova, J. Stary, O. Hrusak, L. Sramkova Department of Paediatric Haematology and Oncology, CLIP, Second Faculty of Medicine and Motol University Hospital; Department of Paediatric Haematology and Oncology, Second Faculty of Medicine and Motol University Hospital, Prague, Czechia Background: The prognosis of relapsed T-acute lymphoblastic leukemia (ALL) is dismal and there is a need for new treatment options.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	We evaluated cell viability by annexin PI staining, lipid peroxidation and ferroptosis by measuring malondialdehyde (MDA) levels and antioxidant gene expression levels by qRT-PCR.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11269933	The CgPK genes are marked with red dotted lines. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "CgPK", "genes", "are", "marked", "with", "red", "dotted", "lines", ".", "(" ] ...
PMC10507284	Sections were incubated with primary antibody (TROAP; Proteintech; 13634‐1‐AP) in PBS containing 3% BSA overnight at 4°C, followed by secondary antibody incubation for 1 h at room temperature.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The primary endpoint is differences in EORTC QLQ-C30 scores between patients with versus without hemolysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "primary", "endpoint", "is", "differences", "in", "EO...
PMC9966931	In conclusion, in the present work, we have proposed industrially-applicable chemical and enzymatic methods for obtaining hybrid molecules based on EO constituents.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11180402	To explore the possible enzymes that mediate ISO-induced hypomethylation of the miR-129 promoter, the levels of three DNMTs and two TETs were analyzed in 5637 cells treated with ISO at different time points.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", ...
PMC11757230	Specifically, cell proliferation was inhibited in CLC and CLK cells through the induction of cell death, in UL-1 and GL-1 cells through the induction of G0/G1 phase arrest, and in Ema and CL-1 cells through both mechanisms.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", ...
PMC8540692	Additionally, the medium for T98G was supplemented with 2 mM glutamine, 1% non-essential amino acids, and 1% sodium pyruvate (all purchased from Merck, Germany).	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC11435360	However, as we observed tumor regression and abrogation of invasion following PAG and GEM combination therapy without any other therapeutic intervention, this may also be a promising treatment for MIBC patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11464982	In yeast processing, following the cell lysis, the food enzyme is added to yeast cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "yeast", "processing", ",", "following", ...
PMC10047551	cg19724470 and cg(chr9:5450951) were significantly demethylated 48 h after transfection with the sgRNAs (Figure 4A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "cg19724470", "and", "cg(chr9:5450951", ")", ...
PMC9429973	HPFH provides genetic and clinical evidence that increasing HbF has the potential to prevent or reduce disease-related pathophysiology, including hemolysis, pain, and VOCs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11422497	NC: negative control.	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "NC", ":", "negative", "control", "." ] } ]
PMC11680982	Further investigation encompassing cell cycle and apoptosis assays by flow cytometry and western blot confirmed the significant induction of G1 phase arrest, concomitant with decreased Cyclin D1, CDK4 and EGFR expression (P < 0.05) (Fig. 3E–H).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9954564	It is considered the most frequent cause of depigmentation worldwide, without preference for ancestry or sex.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "is", "considered", "the", "most", "fr...
PMC11684297	The characterization of synthesized ZnO-NFs was done to identify the absorption spectra, hydrodynamic diameter, stability, functional groups present, and surface topography using UV-visible spectrophotometer, dynamic light scattering, zeta potential, FTIR, and SEM analysis, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8996378	The ability to modulate the MDR by compounds 64–66 was assayed in the MCF-7 cancer cell line (Table 3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "ability", ...

PMC10870498

HEK-293T cells were treated with actinomycin D (ACD, 0.5 µg/mL, Sigma), then existing KIF23 expression was detected at different time point (0, 6, 12, and 24 h) using qPCR.

[ { "tags": [ "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...

PMC11472569

Inhibition of miR-301b-3p or upregulation of TXNIP increased the chemosensitivity of DDP/VCR-resistant gastric cancer cells and reversed malignant behaviors.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Inhibition", "of", "miR-301b-3p", ...

PMC9429973

The venous TE encompassed deep vein thrombosis (DVT, 40%), and Budd-Chiari syndrome (10%).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "venous", "...

PMC11335267

p < 0.05; **p < 0.01, ***p < 0.001; Student’s t-test We hypothesized that the observed effects in Alx3-deficient mice could be related to decreased sympathetic input regulating motor innervation at the neuromuscular junction .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11782780

However, the regulatory role of EBF3 in BC cell stem-like phenotype still requires further investigation.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "the", "regulatory", "role", "of", ...

PMC9429973

Early response was defined as an increased platelets response at 1 week. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Early", "response", "was", "defined", "as", "an", "increased", "platelets",...

PMC11657695

A-673/TR/shEF RNA-Seq data without induction (Day 0) and with induction of shRNA targeting EWS::FLI1 (Day 7) came from the Gene Expression Omnibus database (GEO) GSE164373 .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Thrombosis events (TE) were reported in 33% of patients prior to treatment start (n=42) and 3 (7%) had thrombosis during FU of which 2 patients had no prior history of TE.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC5925824

LY3300054 single agent treatment induced gene expression changes indicative of immune activation, exemplified by increased expression of IFNG, IL2, IDO1, GZMB, IL1B, IL6, while ipilimumab single agent treatment resulted in enhanced T cell activation, exemplified by enhanced ICOS, and IFNG accompanied by downregulation of myeloid genes (CD68, CD14, HLA-DRA).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11344246

RNA was extracted from cell lines and organoids using TRIzol (Invitrogen) according to the manufacturer's instructions.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "RNA", "was", "extracted", "from",...

PMC11711935

Soluble SCF can activate epidermal melanocytes by diffusing to the epidermis.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Soluble", "SCF", "can", "activate", "epidermal", "melanocytes", "by", "diffusing", "to", ...

PMC10887351

While it is known that β2-ARs play a crucial role in BC, Montoya et al. showed that β1- and β3-ARs proteins in BC tissue are expressed more than in the normal mammary epithelium .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8708099

Surprisingly, our results showed that osthole has a higher potential than FXF to decrease the histamine-induced secretion of pro-inflammatory CKs, thus FXF should not be considered as a positive control in this experiment.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11740573

Moreover, it has been demonstrated that calcitriol reduces the production of pro-inflammatory cytokines, such as TNF-α, INF-γ, IL-6, or IL-1, while increasing anti-inflammatory cytokines such as IL-10 .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11673128

These pathways, also known as “don’t eat me” signals (DEMs), have been validated in both solid and blood malignancies, fostering immune evasion and cancer survival .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

The genetic loci used in the prediction included BCL11A but also included NOS1 and ARG2.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "genetic", "loci", "used", "in", "the", "prediction",...

PMC11754094

P values were calculated using Mann–Whitney tests.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "P", "values", "were", "calculated", "using", "Mann", "–", "Whitney", "tests", "." ] } ]

PMC7433824

Hence, the enhancement of this protein may also increase the antigenicity of GBM cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hence", ",", "the", "enhancement", "of", "this", "protein",...

PMC9429973

In vivo deletion of Sucnr1 from Nestin stromal cells promoted expansion of long-term HSC (LT-HSC) versus intact recipients.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "vivo", "deletion", ...

PMC11611077

Transient current Q, current decay τ and total resistance Rt were continuously calculated by the software at a resolution of 25 Hz, by averaging the responses to 10 positive and 10 negative consecutive test steps, and measured values for these parameters were stored in the computer.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11345828

All NMR spectra were recorded at room temperature on a 400 MHz AMX Bruker spectrometer.

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PMC11363012

In cells derived from petals of the SA cultivar, the majority of cells sampled are highly enriched in either rutin (17) (flavonoid)/peonidin 3-O-rutinoside (19) (anthocyanin), the flavonoid mauritianin (16), or a combination of monoterpene indole alkaloids (Figure S17).

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PMC9920575

The procedure was conducted according to the methodology provided in the Caspase-8 Colorimetric Assay Kit (R&D Systems, Minneapolis, MN, USA).

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PMC11724582

E-F) Cell invasion was measured via a Transwell invasion assay (magnification, ×100).

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PMC11805741

Cells were seeded in 6-well plates and followed up until they formed a confluent monolayer.

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PMC7961460

It is highly synthesized by the low metastatic cells.

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PMC11740399

Lipo: liposome, Mem: tumor membranes, ML: cell membrane hybrid liposomes. *

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PMC11537649

Furthermore, to confirm whether Lnc NEAT1 regulated CDK6 expression by sponging miR-152-3p, we simultaneously overexpressed Lnc NEAT1 and miR-152-3p in Hacat cells or simultaneously knocked down Lnc NEAT1 and miR-152-3p in A375 cells.

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PMC4355729

Since the pathway plays an important role in RCC pathogenesis2, it has been showing a great promise for molecularly targeted treatment of RCC69.

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PMC9014716

A and B) The viability of human hepatoma cells treated with PS-T was measured by CCK-8. (

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PMC11422497

Pearson’s correlation analysis showing a negative correlation between circ_SMA4 and miR-494-3p expression in GISTs tissues.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Pearson", "’s", "correlation", "analysis", ...

PMC5417661

Another factor that has overshadowed the therapeutic advancement is the fact that the origin and pathogenesis of OC remain poorly understood.

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PMC11549612

To investigate expression differences among the BOLA family members, we first carried out RT-qPCR to assess the mRNA levels of each BOLA gene in KIRC cell lines.

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PMC11525028

The protein concentrations were determined using the Pierce BCA Protein Assay Kit (ThermoFisher, USA).

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PMC10882807

Despite recent achievements in HCC treatment, its diagnosis and prognosis remain challenging .

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PMC10033453

However, adverse events were observed in the VMG-treated groups that were not dose dependent, with one mouse found moribund on day 6, and 6 out of 20 VMG-treated mice found dead after day 8 (Figure 3B; Table S3).

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PMC7348793

Tandem repeats in mtDNA were identified using Tandem Repeat Finder .

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PMC8345486

Luminescence measurements were then performed to determine the AP-1 and Nf-κB promoter expression levels (Figure 7E,F).

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PMC8348645

DPPH (EEC No. 217-591-8, Sigma, St. Louis, MO, USA), stored at less than 0 °C, methanol, HPLC grade (Ranbaxy Chemicals) was used for the DPPH analysis.

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PMC11665555

Specifically, ketone metabolites like acetoacetate and βHB are associated with increased staging (21).

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PMC11297139

c Live-cell imaging of 293T cells expressing GFP-ARID1A.

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PMC10291556

We demonstrate the superior antiproliferative activity of the new Pt(IV) complexes containing DCF axial ligand(s) against a panel of cancer cell lines of various origins, particularly in the case of Pt(IV) complex 4 (containing two axial DCF ligands), which achieved comparable or even better activity than the parental Pt(II) complex 1.

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PMC11499381

These interactions have all been probed with the split fluorescent proteins fused to the intracellular portion of the protein [2–5].

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PMC11763111

This is probably because the patient's immune system rejects them because of HLA loss or mismatch, which makes them appear alien .

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PMC11779960

T cells undergo sequential rearrangement of TCR V(D)J gene loci, starting with δ, followed by γ, β, and α (Fig. 1a).

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PMC9429973

Iron overload aggravated and iron restriction alleviated the formation of reactive oxygen species, accumulation of DNA damage and levels of the apoptosis marker annexin V in hematopoietic stem and progenitor cells (HSPCs).

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PMC11754432

Cytokine secretion from human skin equivalents (K–O) treated with cytokine cocktail with or without 10 µM ML351 for 6, 24 or 48 h (N = 5).

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PMC11391695

However, additional research is necessary to ascertain whether the treatment is more effective with the PEI/NPs encapsulating the vector coated with HCC cell membrane.

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PMC11767793

The toxicity of the post-centrifugation Au-PEI@NIST was evaluated and compared with the original particles using the CHO K1 cells.

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PMC11377827

Data was analysed with GraphPad Prism v.8.

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PMC11564322

Data denoted as # are statistically different between certain groups at p < 0.05 After the 48-h exposure of the K562 cells to the VVGPGA peptide, an 18.98% decrease in the AKT kinase expression was observed, compared to the control (Fig. 7B).

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PMC10999934

Clusters 2, 3, 8, 9, 10, 22 and 23, containing 10,003 cells, were epithelial cells.

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PMC11365427

This study was supported by the Capital's Funds for Health Improvement and Research (CFH) (Nos. 2020-1-2031 and 2020-2-4082, China), and State Key Laboratory of Respiratory Health and Multimorbidity.

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PMC11033180

Furthermore, Sema5A negatively regulates the spontaneous activity and the frequency of miniature post-synaptic currents of enteric neurons.

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PMC9111184

As a control we investigated the infrared response of untreated Caco-2 cell line (Fig. 1).Fig.

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PMC9822769

The Pt content in the control experiment, which characterizes any possible Pt contamination during the overall process, was statistically insignificant with respect to the cellular Pt accumulated during treatment, even in the case of A2780cisR. Experiments with the inhibitors were carried out at 37°C as follows: (i) NaN3 + 2-deoxy-D-glucose (2DG): preincubation for 30 min in PBS with 25 mM NaN3 and 25 mM 2DG, followed by a 10 μM CT with the Pt compounds in Earle's Balanced Salt Solution (EBSS) for 1 h; (ii) cimetidine (CMT): coincubation with 1.5 mM CMT and 10 μM Pt compounds in EBSS for 1 h; (iii) 1-methyl-4-phenylpyridin-1-ium (MPP): coincubation with 2.0 mM MPP and 10 μM Pt compounds in EBSS for 1 h; (iv) cytochalasin D (CTD): preincubation for 30 min in EBSS with 10 μM CTD, followed by a 10 μM CT with the Pt compounds in EBSS for 1 h; (v) O-benzylserine (BS): coincubation with 1.0 mM BS and 10 μM Pt compounds in EBSS for 4 h; (vi) ouabain (OUA): preincubation for 1 h in EBSS with 1 mM OUA, followed by a 10 μM CT with the Pt compounds in EBSS for 4 h; (vii) tetraethylammonium chloride (TEA): preincubation for 1 h with 2.0 mM TEA followed by 10 μM Pt compounds in EBSS for 4 h. In the experiments at low temperature, A2780 cells were preincubated for 2 h at 4°C, followed by CT with each Pt compound (10 μM) for 4 h. In all cases, at the end of the CT, the cells were manipulated as described in the previous paragraphs.

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PMC8623816

These results indicated that RsRV5 is evolutionarily related to members of the family Partitiviridae.

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PMC11092382

Additional investigations into the interplay between sophocarpine and NF-κB in alternative pathological states are warranted.

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PMC11461833

The protein and mRNA expression levels of STXBP5 were then measured (Fig. 3C, E).

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PMC9429973

Furthermore, Nachun et al. reported that the combined measure of Hannum and GrimAge acceleration modifies the effect of CHIP mutation status, resulting in strongly increased risk of all-cause mortality in individuals with both CHIP and accelerated Hannum age and GrimAge age.

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PMC10926885

The four malignancies in the TIMER2 database that had the strongest correlation with immune cell infiltration are shown in Figure 6C.

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PMC11155445

Inhibitory activity of the new N-acylated thiourea series (156a–u) was evaluated against O. minor radicle elongation.

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PMC11180402

Nevertheless, the roles, mechanisms, and upstream regulator/downstream effectors of SNHG1 in human MIBC invasion and growth have rarely been explored.

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PMC9429973

Algorithmic analysis is performed (R-script) for quality control (QC) and subtype determination and resulting data are verified by the pathologist and loaded directly into the EMR for correlation with clinical data and final diagnosis.

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PMC11770130

With single-cell RNA-sequencing (scRNA-seq) analysis, we have determined that NTS was also produced specifically by lymphatic endothelial cells (LECs) as an anti-thermogenic peptide in brown adipose tissues (BATs) and a pro-lipid absorption peptide regulating the development of atherosclerosis in intestines.

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PMC9429973

Madrid; H.Universitario Virgen del Rocío, Sevilla; H.Vall d’Hebron, Barcelona; H. Universitario Cruces, Barakaldo, Spain Background: Acute myeloblastic leukemia (AML) usually presents with cytopenias, although its degree is variable and in some cases it is non-existent.

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PMC9429973

Statistical processing of the results was estimated by the value of p ˂ 0, 005.

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PMC11449273

All biochemical experiments were repeated at least 3 times and the figures are representative of one typical experiment for each assay.

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PMC11297139

The reads were then assigned into 40 kb genomic bins to generate a 40 kb Hi-C contact map.

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PMC11464982

Controls received the vehicle (water for injection).

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PMC11756907

The cell monolayer, after removing the culture medium, was washed with 0.9% NaCl.

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PMC10969097

The data were exported to the reference manager.

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PMC9429973

There was no statistically significant difference in mortality between CD patients with and without IDA (Odds ratio (OR): 0.79; 95% confidence interval (CI): 0.595-1.049, P= 0.103).

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PMC10874773

Acetal-hemiacetal and/or ortholactone: This class of sesquiterpenes has been reported to be composed of unique acetal-hemiacetal and/or ortholactone structure, and it can be expected that they may be in equilibrium between acetal-hemiacetal and aldehydes or between normal esters and lactones (Fig. 7).

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PMC11453690

A. Zhang: None.

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PMC10530622

Post-translational modifications regulate its activity, namely N-glycosylation at amino acids 167 and 172 within the putative second extracellular loop, particularly its efficacy on oxalate transport, not influencing its plasma membrane delivery .

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PMC11756937

In summary, our study demonstrates that while the source material does not significantly impact reprogramming success rates, the SeV method is notably more effective than the episomal approach, providing crucial insights for the reliable and reproducible generation of high-quality hiPSCs in biobanking.

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PMC9429973

C-MYC/BCL6 HGBL DH and HGBL NOS are more heterogenous and in some cases can be represented by transformation of MZL with paraprotein secretion.

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PMC10547921

Chemical structures of IRDye700DX (128); (B) The mechanism of NIR-PIT ADC.

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PMC9429973

However, cases of ATE were noted at diagnosis (1 (5.6%) patient), after transplantation (1 (5.6%) patient) or at relapse (1 (5.6%) patient) as well.

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PMC9429973

Summary/Conclusion: Imbalances in MTHFR homocysteine metabolism associated with the polymorphisms do not appear to be a risk factor for ALL in the study cohort.

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PMC9429973

Mechanistically, we implied NOTCH1 signalling activation in Bcor loss mediated tumorigenesis with potential for targeted treatment for high-risk CLL and RT patients.

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PMC9429973

B. Vakrmanova, M. Novakova, P. Riha, M. Zaliova, E. Fronkova, E. Mejstrikova, L. Reznickova Rezkova, J. Stary, O. Hrusak, L. Sramkova Department of Paediatric Haematology and Oncology, CLIP, Second Faculty of Medicine and Motol University Hospital; Department of Paediatric Haematology and Oncology, Second Faculty of Medicine and Motol University Hospital, Prague, Czechia Background: The prognosis of relapsed T-acute lymphoblastic leukemia (ALL) is dismal and there is a need for new treatment options.

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PMC9429973

We evaluated cell viability by annexin PI staining, lipid peroxidation and ferroptosis by measuring malondialdehyde (MDA) levels and antioxidant gene expression levels by qRT-PCR.

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PMC11269933

The CgPK genes are marked with red dotted lines. (

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PMC10507284

Sections were incubated with primary antibody (TROAP; Proteintech; 13634‐1‐AP) in PBS containing 3% BSA overnight at 4°C, followed by secondary antibody incubation for 1 h at room temperature.

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PMC9429973

The primary endpoint is differences in EORTC QLQ-C30 scores between patients with versus without hemolysis.

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PMC9966931

In conclusion, in the present work, we have proposed industrially-applicable chemical and enzymatic methods for obtaining hybrid molecules based on EO constituents.

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PMC11180402

To explore the possible enzymes that mediate ISO-induced hypomethylation of the miR-129 promoter, the levels of three DNMTs and two TETs were analyzed in 5637 cells treated with ISO at different time points.

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PMC11757230

Specifically, cell proliferation was inhibited in CLC and CLK cells through the induction of cell death, in UL-1 and GL-1 cells through the induction of G0/G1 phase arrest, and in Ema and CL-1 cells through both mechanisms.

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PMC8540692

Additionally, the medium for T98G was supplemented with 2 mM glutamine, 1% non-essential amino acids, and 1% sodium pyruvate (all purchased from Merck, Germany).

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PMC11435360

However, as we observed tumor regression and abrogation of invasion following PAG and GEM combination therapy without any other therapeutic intervention, this may also be a promising treatment for MIBC patients.

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PMC11464982

In yeast processing, following the cell lysis, the food enzyme is added to yeast cells.

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PMC10047551

cg19724470 and cg(chr9:5450951) were significantly demethylated 48 h after transfection with the sgRNAs (Figure 4A).

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PMC9429973

HPFH provides genetic and clinical evidence that increasing HbF has the potential to prevent or reduce disease-related pathophysiology, including hemolysis, pain, and VOCs.

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PMC11422497

NC: negative control.

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PMC11680982

Further investigation encompassing cell cycle and apoptosis assays by flow cytometry and western blot confirmed the significant induction of G1 phase arrest, concomitant with decreased Cyclin D1, CDK4 and EGFR expression (P < 0.05) (Fig. 3E–H).

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PMC9954564

It is considered the most frequent cause of depigmentation worldwide, without preference for ancestry or sex.

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PMC11684297

The characterization of synthesized ZnO-NFs was done to identify the absorption spectra, hydrodynamic diameter, stability, functional groups present, and surface topography using UV-visible spectrophotometer, dynamic light scattering, zeta potential, FTIR, and SEM analysis, respectively.

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PMC8996378

The ability to modulate the MDR by compounds 64–66 was assayed in the MCF-7 cancer cell line (Table 3).

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