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PMC11529598
A. Migration ability of miR-3154 sponge U251 cells and control U251 cells was measured using Transwell assay. *
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PMC7570809
Reblot was performed using a harsh stripping buffer containing 2% SDS, 60 mM Tris HCl, pH 6.8, 0.8% β-mercaptoethanol, incubating the membrane at 50 °C for 30 min with some agitation.
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PMC11188874
D, Plot of the effect of pharmacologics on proteasome activity versus the effect on cell viability.
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PMC9429973
Antibodies of the ABO system (anti-A) IgG were present in the recipient’s blood for 189 days, IgM - for 230 days.
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PMC8728081
SEM imaging of drug-treated cells was also conducted.
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PMC11721295
Furthermore, upon boiling TCM from the ON group, the effects on Cxcl5 expression were lost, indicating that TCM factors are destroyed by heat exposure (Figure 6D).
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PMC11541409
This reference is of importance because it reports that pimitespib is a promising drug for advanced GIST patients.
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PMC4816271
To evaluate the effects of vector modifications over more prolonged periods, transduced PBMCs were then cultured for a total of 7 days.
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PMC10858941
Coverslips were mounted on Mowiol (Mowiol4-88, glycerol 50%, 0.2 M Tris-HCl, pH 8.5).
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PMC11740399
The maximum absorption wavelength of SRT3025 was determined using ultraviolet-visible (UV-Vis) scanning spectroscopy.
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PMC11694066
We therefore used the clinical-grade CHK1i prexasertib and found additive effects with talazoparib in the JN1 cell line (Bliss synergy score = 6.00) but not in the R cell line, again consistent with the limited sensitivity of the latter to PARPi monotherapy (Supplementary Fig. S6C–S6F).
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PMC10745221
Although changes in histone lysine methylation between the 143B-P and 143B-R cells were seen previously, the method of cell lysis may not have lysed the nuclear membrane and did not solubilize histones, as shown in the Coomassie-stained gel that lacks histone bands .
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PMC9429973
There was no difference in the outcome between patients with CNS involvement and those without.
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PMC10870498
Data are expressed as mean ± standard deviation (SD).
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PMC11774747
The generation of VST opens avenues for the development of CAR-VST, offering distinct advantages in terms of quantity and subpopulation diversity.
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PMC8973725
Western blot assays revealed that ectopic expression of ZNF677 decreased the expression of p-AKT, suggesting that this molecular pathway may be involved in ZNF677-driven EMT (Figure 5c).
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PMC10940855
Analysis of PB and thoracic spine of transplanted mice also demonstrated nearly undetectable CD138GFP multiple myeloma cells in mice transplanted with dEFNB2-expressing multiple myeloma cells compared with mice transplanted with equal doses of control multiple myeloma cells (Fig. 5H).
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PMC10957991
On the right side panel, differences in junction protein area, interface occupancy and area of the junction protein, coverage index, intensity per interface, and cluster density in between ctrl and TRPV4 siRNA-treated 184A1 epithelial sheets are shown with box blots with inner and outer points and mean.
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PMC7154001
The literature search was performed through PubMed and ScienceDirect databases up to January 2019.
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PMC6835428
While GPC3 is over expressed in chemo-resistant OC cells, its overexpression seems to occur mostly in clear OC cell adenocarcinoma rather than in HSGOC .
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PMC11632064
Immunoblotting of differentiation markers in cell extracts from MeWo cells treated with DMSO or RSK inhibitors for 72 h. Numbers above pictures indicate paired independent experiments. (
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PMC11594806
The authors concluded that MTX acts synergistically with AICAR to inhibit cancer cell proliferation and tumor growth in nude mice .
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PMC8382973
was 7.5 min for 2P23.
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PMC6160470
None of the other compounds induced statistically significant Rho123 efflux inhibition compared to verapamil.
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PMC10607604
PTPN13 KO and KD in KURAMOCHI cells, which enhanced migration and invasion, also moderately increased the expression of EMT driver genes and decreased DPK expression.
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PMC10093184
Cells seeded in 6-well plates (Sarstedt) were trypsinized at regular time intervals and the cell amount was determined by an automated cell counter (COUTNESS, Invitrogen, Carlsbad, CA, USA).
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PMC9429973
In recent years, with the advent of CART cell therapy, the PFS and OS of relapsed and refractory highly aggressive B-cell lymphoma have been significantly improved.
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PMC10899471
These data revealed that miR-939-3p enhanced sarcoma growth in vivo.
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PMC6450504
Encapsulating paclitaxel (PTX) into PEIPOS did not change its main mechanism of action.
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PMC9429973
Subtype-defining aberrations were identified in 36.0% of the patients with hyperdiploidy and iAMP21 detected in 32.2% and 3.8% of the cases, respectively.
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PMC11534377
This observation suggests a decrease in metabolic function and disruptions in actin structure, indicative of structural changes within the cells.
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PMC10887351
Bruno et al., in a murine syngeneic model of NB, have studied if the β3-AR modulation could influence the response of the host immune system against the tumor .
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PMC11638288
Alon et al. demonstrated that the NK cell receptor NKp46/NCR1 acts as a receptor for the fungal pathogen Candida albicans.
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PMC10898159
In response to SCF stimulation, KIT propagates the signal of survival and proliferation to ICC, maintaining the function of gut motility [8–10].
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PMC11201989
Second, several centriole proteins such as CEP83, CEP97 and CP110 , localize at the immune synapse in CTL .
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PMC9065483
Dotted lines represent viability and titer thresholds (60% and 1.5 fold-change, respectively). (
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PMC9429973
Three of 18 (16.7%) patients relapsed (CD7- 1, CD7 + 2) after transplantation and have been receiving treatment so far.
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PMC11721587
The supernatants were collected after centrifugation and incubated in 65°C water bath overnight.
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PMC10748106
Only one of them had an acid in this position D10.
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PMC11144200
Using the previously mentioned fluorescence microscope, the fusion cells’ fluorescence level had been recorded.
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PMC11643361
Furthermore, dipodal ligands show unique potential, with selective binding sites that improve stability and facilitate specific cellular interactions, such as targeting metastatic pathways.
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PMC11705484
This study was approved by the Ethics Committee of the First Affiliated Hospital of Zhengzhou University, and written informed consent was obtained from the patients or their relatives prior to the study.
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PMC11461874
Data are presented as mean ± SEM (n = 4) by setting the mean of control condition to 1.
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PMC9479186
We knocked down the expression of NDUFC1 in HCC cell lines to explore the effects of NDUFC1 downregulation on HCC in vitro.
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PMC11568601
Until now, nearly 196 chemical components have been discovered from the plant, with C21 steroidal glycosides identified as characteristic compounds that exert antitumor effects through multiple mechanisms .
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PMC8978939
Introducing variants affects specific interactions at the level of amino acid side chains directly in their local environment, and for L163R, it is propagated far away into the pVHL: HIF-1α interface.
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PMC10213179
To collect kinetic binding data, concentrations series of the aptamers in 20 mM HEPES, 150 mM NaCl, and 2 mM CaCl2 (pH 7.4) supplemented with 0.01% Tween 20, were injected over the two flow cells at a flow rate of 30 μL/min and at a temperature of 37°C.
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PMC10667689
In the THP-1 cell line, the expression of the same genes was significantly increased in all studied groups compared to the control and PMA groups, though the maximum increase was observed after 48 h of treatment with Gal-9.
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PMC9429973
Twelve patients (75%) underwent prior autologous stem cell transplantation (ASCT), and 5 patients had prior lenalidomide.
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PMC6835428
Despite this, as A2780 are CD44-negative and do not over express PLXDC1, the data presented suggest that the therapeutic effect was mostly due to an anti-angiogenic action.
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PMC11344246
However, when diagnosed at an advanced stage, standard of care carboplatin/paclitaxel chemotherapy is ineffective, with a median survival of under 15 months (5).
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PMC11566417
The potential for tumorigenesis is further reduced as the goal of this study was to produce consistently reproducible MDEC secretome as a safer alternative to using cell-based treatments, thus, no cells would be engrafted into host tissues, bypassing concerns commonly associated with cell-based therapeutics .
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PMC11257203
The cultured blood samples were treated for 24 h as follows: (1) The control group treated with cosolvent and normal saline; (2 and 3) indomethacin groups treated only with indomethacin at 100 and 200 μΜ (15); (4 and 5) indomethacin-curcumin groups treated with indomethacin at 100 and 200 μΜ plus curcumin at 27 μΜ (16).
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PMC11697189
Traditionally, according to different molecular weights, HSPs are divided into 6 families, including small heat shock proteins (sHSPs), HSP40 (DNAJ), HSP60 (HSPD), HSP70 (HSPA), HSP90 (HSPC) and large HSPs (HSPH).
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PMC11721064
Firstly, to enhance the production of mature corneal epithelial cells and achieve a stratified cell sheet resembling the native corneal epithelium, some consistent and efficient stratification methods should be implemented, such as air–liquid interface culture .
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PMC9429973
Median duration of OBDS injection was 10 min.
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PMC11092382
Moreover, pharmacological parameters, such as dose range, minimum active concentration and duration still merit further exploration.
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PMC11204465
The basic skeleton of these two classes of compounds is shown in Figure 9.
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PMC7081114
First, we analyzed the differential expression of KIF21B in The Cancer Genome Atlas, and used immunohistochemical staining to validate it.
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PMC9429973
Dual blockade of PD-1 and lymphocyte-activation gene 3 (LAG-3) has demonstrated antitumor activity in preclinical models.
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PMC9429973
Methods: A systematic literature review (SLR) and grey literature search was conducted to identify published observational studies that reported outcomes of eculizumab treatment in patients (aged ≥18 years) with PNH.
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PMC10560648
Growth inhibition and toxic effects of Cassiopea andromeda Venom were evaluated by methyl thiazole tetrazolium salt reduction (MTT test).
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PMC11519583
Proportion of MPs (h) and Ki-67-positive MPs (i) in untreated, Ctx-, or glycerol-injected mice was monitored by flow cytometric analysis (untreated: n = 6 (h) and n = 3 (i), Ctx: n = 10 (h) and n = 6 (i), glycerol: n = 10 (h) and n = 6 (i)).
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PMC11537649
miR-200a in metastatic melanoma cells induces cell cycle arrest by targeting CDK6, reducing cell proliferation; these effects are recovered by overexpression of CDK6.
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PMC11767725
Both innate and adaptive immunity play critical roles, with elevated levels of IL-1β, IL-17, TNF-α, and IL-12/23 perpetuating inflammation.
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PMC11469524
While proximal BCR signaling is well studied, little is known about the crosstalk of downstream effector pathways, and a comprehensive quantitative network analysis of BCR signaling is missing.
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PMC9429973
Image: Summary/Conclusion: In our experience, Broviac was associated with an increased risk of bloodstream infections.
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PMC11721064
LNCs were maintained in adherent culture for an additional 21 days (passaged to P3) in MESCM, with medium replacement three times weekly to achieve LNC purification.
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PMC9436459
Compounds 92–98 all possess a prenyl group or structure derived thereof at C-3.
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PMC11766174
It should be noted, however, that the requirement for specialized equipment, including an autostainer and digital pathology scanner, is a disadvantage of the CA-ICC protocol.
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PMC11468365
In this paper, multi-head attention is used.
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PMC10667689
In conclusion, the present study revealed that TIM-3/Gal-9 interaction induces metabolic reprogramming in AML in a time-dependent manner, which is probably activated following the PI3K/Akt/mTOR and ERK signaling pathway.
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PMC11411131
To verify the synthetic model of the NMD pathway, GPx1 cDNA, including its intron, was transfected into Cos-7 cells.
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PMC4360730
The ‘Biosample treatment’ facet displays the term names for treatments, some of which are annotated to ChEBI.
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PMC11144382
RA is a metabolite and biologically active form of vitamin A, with complex and pleiotropic functions throughout life but particularly during embryogenesis where it regulates cell lineage and stem cell differentiation in developing tissue and organ systems, including the facial region, hindbrain, forebrain, eye and inner ear.
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PMC9429973
Results were compared to serum protein electrophoresis, immunofixation, and FLC ratios (Freelite®, The Binding Site, UK).
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PMC11706776
F Effect of the SK1 channel activator GW542573X on SOCE in A-673 cells and the relative fluorescence measurement of SOCE induced by TG in GW542573X conditions (N = 14 for Control and N = 21 for G542573X condition).
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PMC8316344
Exogenous Ub-HA, βTrCP-FLAG, and TFRC-Myc were ectopically expressed, as indicated in HEK-293T treating with MG132 (8 µM).
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PMC11536589
Scale bar: 100 μm.
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PMC9429973
The performance of the model was evaluated in an independent set of 436 MDS patients and the accuracy was assessed using a concordance (c)index and the area under the Receiver Operating Characteristic curve (AUC) at each time point.
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PMC9429973
In GBT021601-012, patients with SCD completed treatment with no AEs leading to study discontinuation.
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PMC11401350
For both stimulations the PGK CAR mCD8-LVs outperformed by far the EF1aCAR mCD8-LVs in transduction levels as well as expression levels indicated as mean fluorescence intensity (MFI) of the CAR expression (Fig. 2D-G).Fig.
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PMC11758416
For example, if the lowest count of T cells recovered per condition is 9E4 T cells, then the number of T cells per well should be 4.5E4 T cells each in duplicate (to allow for a technical replicate).
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PMC11612315
Compared with intraplantar administration of CAP alone (1.6 μg), additional intraplantar injection of exendin 20–29 (20 μg) significantly alleviated pain from 60 to 120 min (Fig. 8e), as manifested by increased PWL in the Hargreaves test.
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PMC11627060
The samples were combined into a 1 mL stock following filtration.
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PMC11683240
Cells were left untreated as further control.
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PMC7757104
The PCR primers sequences are listed in Table I. After reaching 90-95% confluency, ACRP or OVCar-8 Dox cells were transfected with 100 nM anti-OPNc phosphorothiotate-modified antisense DNA oligomer (ASO anti-OPNc; 5′-A*C*A*AC*GCATTCTGCTTT*T*C*C-3′) or with a non-specific/scrambled control sequence (ASO SCR; 5′-C*C*T*T*TTCGTCTTACGAC*A*C*A-3′), using Lipofectamine 2000 (Invitrogen; Thermo Fisher Scientific, Inc.) according to the manufacturer's instructions.
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PMC11279598
Notably, high levels of tyrosine-phosphorylated signal transducer and activator of transcription 3 (p-STAT3) are found to be constitutively activated in a number of malignancies, including almost half of all human breast cancers and act as oncogenic transcription factors.
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PMC8584666
As GPI-80 is a GPI-anchored protein, via the enzymatic activity of GPI-80, cysteamine is synthesized on the cell membrane as an ectoenzyme.
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PMC11633763
This binding activates PFKFB3's transcription, increases PFKFB3's expression and glycolysis, and encourages the growth and spread of lung cancer .
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PMC9621239
D and E) Protein levels of MYC in hepatocellular carcinoma cells.
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PMC11786156
Student’s t-test, Welch’s t-test, Chi-squared test, Dunnett correction, Kaplan–Meier plots, and log-rank tests were performed using IBM SPSS Statistics 24 (IBM Corporation, Armonk, New York, USA), with P-values of ≤0.05 indicating statistical significance.
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PMC9429973
Expression of immunohistochemical markers was not significantly different between groups.
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PMC11747949
Gating strategy of CD44 expression and quantification of the % of CD44 and CD44 in CD44 cells. (
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PMC7802142
The up-regulation of these miRNAs was confirmed by RT-PCR (fold change = 168.6, 49.1 and 17.5, respectively) (Fig. 6c).
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PMC11443022
Abdominal computed tomography image.
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PMC11770130
In addition, it has been demonstrated that ceramides C20–C24 are negative regulators of the unfolded protein response (UPR).
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PMC8973725
In contrast, knockdown of the PI3K/AKT signaling pathway reduces the expression of N-cadherin, Twist, and Zeb1, accompanied by the expression of E-cadherin, in papillary thyroid carcinoma cell lines .
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PMC6835428
Moreover, the higher flow rate (100–500-fold) in blood vessels compared to lymphatic capillaries favors the diffusion of small molecules into the blood .
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PMC11711063
Thus, mechanical forces transduced by mechanotransducers and select integrins in non‐malignant cells play a major role in determining proliferative activity, stem cell‐like phenotype and tumorigenic potential. , ,
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