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OTAR3088
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BioData-CellLine_annotated

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PMC4659567
As for the GSH region, two triplets of Cys-α CH were detected at 4.49 and 4.55 ppm and two Cys-β CH2 signals were found at 2.77 and 2.86 ppm, with an integral intensity of signals at 4.49/2.86 ppm versus those at 4.55/2.77 ppm being ca 1: 9.
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PMC11740207
Importantly, this study did not cover VSELSCs and their morphology.
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PMC11643361
The iron(II) complex was able to decrease the ability of HCT116 and HaCaT cell lines to migrate, but enhanced the migration rate of B16 cells, while cobalt(II) complex 39 inhibited the cell migration ability of all tested cell lines.
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PMC11634027
Constructs with smaller deletions within the D motif were expressed in S2 cells together with tagged Lft, Dachs, or Sple.
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PMC11354239
For cDNA synthesis, the reaction included 1 μg of DNase I-treated RNA, 1 mM dNTP mix, 2.5 μM random nonamers, and 2.5 μM oligo(dT)23 primers.
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PMC11476004
Squamous cell tumours affecting several epithelial cell lines (of both the epidermis and mucous membranes) are among the most common tumours in dogs .
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PMC10547921
Maytansinol has been regarded as a valuable lead compound.
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PMC11768927
This study underscores the critical role of TAMs in promoting resistance to VSV virotherapy through innate immune mechanisms, presenting a potential barrier to the effective use of VSV as an oncolytic agent in these cancers.
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PMC10999934
11,300 cells were divided into 20 separate clusters with resolution 0.8. (
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PMC9786247
IFN-γ promotes an up-regulation of major histocompatibility complex (MHC) expression in epithelial cells .
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PMC9080589
Protocadherin8 (PCDH8), a member of the protocadherin (PCDH) family, is involved in the progression of several types of cancers.
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PMC11568601
Our study demonstrated that TGT exerts an effective anti-osteosarcoma effect by activating the IRE1/CHOP pathway, ultimately triggering the apoptosis of osteosarcoma cells (Fig. 9).
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PMC9096373
We present the following article in accordance with the ARRIVE reporting checklist (available at https://atm.amegroups.com/article/view/10.21037/atm-22-1442/rc).
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PMC11659921
Through multivariate Cox regression analysis and Friends analysis, we identified TNFSF11 as the most significant prognostic gene associated with angiogenesis and stemness.
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PMC11629461
Specifically, cellular works with mutated NOX5, together with biochemical works with purified NOX5 or DUOX2 proteins, and cryoEM studies of such enzymes with tagged protein photosensitzers (such as miniSOG) in the future, will reveal the detailed mechanisms of UVA and photodynamic activation of NOX enzymes.
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PMC11496728
In exploring the mechanism of the increase in the expression of recombinant proteins, total DNA was extracted from cells that transiently expressed SEAP and IL-3 and stably expressed SEAP and IL-3 (CHO-WT and CHO-KO).
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PMC11781181
In our previous and present studies, we have highlighted the importance of apoptosis and ferroptosis in the pathogenesis of SJS/TEN patients.
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PMC5173112
MTT and colony formation assays were used to demonstrate that knockdown of USP21 markedly reduced the growth at day 5 and 6 (Figure 3B) and clone-formation (Figure 3C and 3D) rate of A-704 cell lines as compared with that of control transfected cells.
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PMC9429973
A broad range of survival models (standard parametric, cubic spline, mixture cure, and mixture models) were fit to multiple data cutoffs, with varying follow-up durations for each study.
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PMC6642070
Lactate concentrations in gastrocnemius (GAS) and tibialis anterior (TA) muscles of C57BL/6 J mice co-administered with lovastatin and DCA for 30 days (n = 10 each group).
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PMC7192625
The total PCHi-C networks can hence be subdivided into PP and PO subnetworks.
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PMC11261875
Fig. 1 illustrates the relationship among GIST, glycolysis, and oxidative phosphorylation.
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PMC7802142
Furthermore, we evaluated the amount of the miRNAs in DPCs after incubation with PBS, 293-NV or ReN-NV.
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PMC11066331
In the case of pure populations only, the accuracy reached 100 % consistently (data not shown).Fig.
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PMC11785489
We identified recently activated T cells (CD69, MK67, CD38, HLA-DR) in dataset 1 and observed that TCR-mem in this subset was just as high as TCR-mem in other memory subsets (Figure 4A).
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PMC11763764
The slides were washed with 1× wash buffer B twice and 0.01× wash buffer B for 1 min.
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PMC9786247
The most commonly adopted methods to define phylogeny are multi-loci variable-number tandem repeat analysis (MLVA) and multispacer sequence typing (MST), with MLVA being more discriminatory than MST .
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PMC11594074
A total of 100 µL of primary antibody Ki-67 (D3B5) was prepared in antibody dilution buffer, and then the cells were treated and incubated for 1 h at RT.
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PMC9429973
Cytogenetic analysis was performed on lymphocytes and bone marrow cells.
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PMC11106977
Both isoforms are comprised of a glycoside hydrolase 84 (GH84) catalytic domain at the N-terminus and a helical bundle stalk-like domain.
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PMC11144200
There was an increase in cytokine release levels compared to the FC + LPS-DOX+Nb36 groups.
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PMC11201989
We found that PD-L1 is enriched at the centrosome/basal body and Golgi apparatus of ciliated cells and depleting PD-L1 enhanced ciliogenesis and increased the accumulation of ciliary membrane trafficking proteins Rab8a, BBS5, and sensory receptor protein PC-2.
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PMC11697065
< 0.01, * ** ** <0.0001.
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PMC10994876
The PE and 7-AAD fluorochromes were excited by 488-nm laser with an emission peak at 578 nm and 650 nm, respectively.
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PMC11607638
The structures of mosquito sulfakinin receptor and lower vertebrate receptors need to be solved.
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PMC9429973
Results: The angiogenic factors eNOS, VEGF and HIF1α have significantly higher frequencies in MNC of CLL in comparison to healthy controls (p<0.001), while they were reduced in CD19 immunoreactive cells compared to MNC.
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PMC10158546
Figure 2.Enrichment of GFP expressing transduced ReN cells using puromycin antibiotic selection. (
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PMC6450504
The combined results of flow cytometry and CLSM analysis indicate that bPEI coating not only helps to increase cellular association of the liposomes with cells in monolayers, but it also allows higher penetration and interaction of liposomes with cells in 3D tumor spheroid models.
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PMC8526701
with 5 × 10 WT or PUMA-KO GIST-882 cells.
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PMC11674834
Quantitative RT-PCR (RT-qPCR) assays were used to assess the relative amount of CYP1A2 mRNA in cells in CHO cells.
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PMC11310713
It was observed that ovarian sex hormone levels recovered after injection of GTBs (Fig. 4A and B).
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PMC11742290
In vivo, lineage tracing experiments were conducted to evaluate LGR5 expression in intestinal crypts .
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PMC11335267
Representative MRI coronal and axial planes used for quantification.
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PMC9587298
To study if and which polyphenols present in elderberry extracts were the main ones responsible for the observed MGO trapping activity, elderberry extracts were analysed after 30 min reaction with MGO.
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PMC11271278
Interestingly, these enhancers have little or modest regulatory effects on the nearby gene FOXA1 or TTC6 on their original chromosome in LNCaP cells (Figs. 3B and S3D), indicating that these two genes may be dependent on additional enhancers.
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PMC11365427
Through the identification of metabolites, we categorized them into several groups, covering amino acids, organic acids, nucleotides, nucleosides, organic amines, acylcarnitines, vitamins, carbohydrates, and lipids.
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PMC11705547
Since mitochondria is the primary site of ROS production, cisplatin-induced oxidative stress often leads to abnormal mitochondrial calcium uptake, mitochondrial membrane depolarization and decreased ATP synthesis, eventually activating the apoptotic pathway (Figure 1).
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PMC11267036
Nevertheless, the implication of STAT1/RIG-I axis in EMT and tumor growth in MM is still unclear.
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PMC11240448
This indicates that the cSTAR predictions remain consistent even after the removal of any analyte from the CYTOF dataset.
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PMC11583010
At the indicated time (black arrowhead), three different ADCs were injected intravenously: isotype control (8 mg/kg) conjugated to maleimide–ß-glucuronide–exatecan–PSAR (open diamonds), ETx-22 (from chimeric 15A7.5 mAb) at 4 and 8 mg/kg (open and plain blue arrowheads, respectively), and EV at 4 mg/kg (plain brown arrowhead).
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PMC11468365
All the previous methods used a reference model to calculate the synergy.
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PMC11411004
P < 0.0001 vs. DMSO, and ***P < 0.001 vs. DMSO CHO-ADM cells treated with DMSO or 2 μM I-4 and Western blotting to detect changes in the protein expression levels of HDAC substrates a Ac-H3K9 and Ac-H3K27 and LSD1 substrate b H3K4me2 and total histone H3, LSD1 proteins.
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PMC7154001
On the other hand, in some cases, metabolism may lead to reactive metabolites that can induce adverse effects.
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PMC5173112
Furthermore, decrease USP21 levels is associated with repression of interleukin 8 (IL-8), a chemokine that regulates CSCs characteristics in RCC.
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PMC10568263
A facile approach for the synthesis of MoO3 nanosheets was developed by thermally oxidizing MoS2 nanosheets in air followed by thermal annealing.
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PMC9429973
One patient with refractory disease received only 1 course dose adjusted HyperCVAD.
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PMC9817179
We hypothesize that this is because fixing the bound state of an LLPS system (within puncta) is dominated by cross-linking reactions between IDRs enriched in puncta, which have reactive residues better exposed to solvent due to lack of well-defined tertiary structures and thereby likely cross-link faster than structured domains cross-linking to DNA (Hoffman et al., 2015).
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PMC11365983
Animal experiments were approved by the IACUC of the University of Alberta.
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PMC11740207
While the ALT mechanism is less common than telomerase activation, it represents a significant strategy for tumors that do not utilize telomerase, enabling them to bypass the HE and divide indefinitely (Cesare and Reddel, 2010).
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PMC11786704
These findings reveal the potential mechanism of PC capsules in diabetic wound treatment and provide theoretical support for its clinical application.
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PMC6163708
HH signaling produces self-renewal in embryonal rhabdomyosarcoma , has a critical role in the growth of neuroblastoma , ovarian cancer , hepatocellular carcinoma , colon carcinoma , and is pivotal for forming breast cancer CSC and bone metastases .
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PMC11033180
After FM1-43 loading in neurons within synaptic vesicles, enteric neurons were stimulated by KCl-induced depolarization for 4 min and the fluorescence decrease was recorded.
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PMC8973085
calcd for C29H22FN3O2S: C, 70.29; H, 4.47; N, 8.48.
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PMC11576293
The docking study showed that compounds 22 and 29 had docking scores similar to those of Erlotinib and Sorafenib, co-crystallized ligands, for the EGFR and VEGFR-2 proteins.
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PMC8382973
Heat map showing the top 23 similarly abundant genera in the rectum versus vagina.
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PMC9429973
Shortly after tamoxifen administration, most of the recipient mice that were reconstituted with bone marrow (BM) from Ddx41 or Ddx41 mice died within a month after CreERT2 induction due to severe BM failure (BMF).
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PMC6468656
Taken together, the findings demonstrate ghrelin’s multi-function in promoting cancer metastasis.
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PMC8345486
For crystal data and structure refinement, see Table S1 in the Supplementary Materials.
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PMC11711127
Hence, further exploration of characteristics and roles of senescent T cells can help in using these cells as potential therapeutic targets in many diseases.
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PMC11461874
Together, TRAF7 is most likely to regulate UBE2T/UBE2G1-mediated degradation of DBP, and this degradation system should be a key mechanism underlying the robust temporal regulation of DBP protein levels.
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PMC9429973
Early detection of impending relapse would enable pre-emptive treatment and potentially reduce relapse risk but is limited by the lack of sensitive markers for measurable residual disease (MRD).
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PMC11435360
Therefore, it is not possible to confirm with our findings as to what type of macrophage is abundant in this response.
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PMC9895440
In addition, cells were co-transduced with LentiCRISPRv2-mCherry virus at an MOI of 0.5.
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PMC10114490
A Unsupervised hierarchical clustering of samples and genes obtained from RNAseq data (see details in methods).
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PMC7841067
Previous studies demonstrated that AKAP4 plays a role in tumor development and progression in a variety of cancers, including esophageal, ovarian, breast, and lung7–10.
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PMC11621565
Rhamnolipid 90% (cat.no.
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PMC11802855
Subpopulations of MM cells with elevated CXCL7 expression show enhanced activation of the osteoclast signaling pathway.
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PMC11412721
Comparative maps of the wild-type (WT) and ΔAS Trp53 alleles.
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PMC8073654
Recently, the discovery of phenylbutenoids was reported for the plant of another family, Dryopteris fragrans (Dryopteridaceae) .
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PMC11787651
Histone peptides were identified and quantitated using EpiProfile, a library-free DIA search software designed specifically for DIA analysis of tryptic digests of propionylated histone samples (59).
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PMC9844987
Top: density plot of promoter expression per gene category.
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PMC11748363
None of the tested compounds exerted significant antibacterial or antifungal activities.
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PMC11721587
NIH3T3 cells expressing Ulk3-HA and Flag-Gli2 at endogenous loci were treated with control (eGFP) or Kapβ2 shRNA in the presence or absence of Shh, followed by immunostaining to examine Ulk3/Gli2 ciliary localization (top) or IP and WB analysis to examine Ulk3 maturation and Gli2 phosphorylation (bottom). (
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PMC10587429
Fetal Bovine Serum (FBS, 16000044, Thermo Fisher Scientific, Waltham, MA). -
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PMC11476837
Moreover, 50 µM ML-385 slightly increased the HMOX2 mRNA level by itself (p < 0.05).
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PMC11538390
The geographic distribution of allele frequencies was calculated and plotted using region-level, birthplace data of 306,678 FinnGen study participants obtained from Statistics Finland, with the ggplot2, ggrepel and sf R packages.
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PMC6892818
786-O RCC cells served as positive control for mCD40L-mediated DNA fragmentation.
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PMC11656657
CRISPR/Cas9-mediated CXCL8 Knockout (KO) and CRISPR/Cas9-mediated CSF3 KO in 143B cell line was performed using the Alt-R CRISPR-Cas9 System (Integrated DNA Technologies, IDT, USA) through electroporation with the Amaxa 4D-Nucleofector System (Lonza, Basel, Switzerland).
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PMC11185260
It has been reported that main subcellular locations of SMARCB1 protein are nucleus and cytosol.34 Although we did not study the subcellular distribution of the restored SMARCB1 protein, using scL nanocomplex carrying GFP plasmid DNA as a model payload (scL-GFP), we have previously examined subcellular localization of exogenous GFP protein in human colorectal cancer (HT-29) and human glioblastoma (U251 and U87) cell lines.33 We have observed a strong nuclear expression and lower cytoplasmic expression of exogenous GFP in all three cancer cell lines.
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PMC11637820
Nitric oxide (NO), also known as nitrogen monoxide, is a gaseous molecule considered one of the principal oxides of nitrogen.
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PMC11286266
In addition to the identified S1P and S2P proteases, the screen for ATF6α activators identified FURIN, a Golgi-localised protease belonging to the subtilisin-like proprotein convertase family (like S1P protease) responsible for proteolytic activation of a wide array of precursor proteins within the secretory pathway (Braun and Sauter, 2019).
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PMC11740207
The Wnt pathway is also more active in LT-HSCs, helping regulate their regenerative capacity.
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PMC11075223
Abnormal lipid levels in the blood might cause fatty liver, diabetes, cardiovascular and other related diseases, which greatly threatened human health .
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PMC11095939
Here, we show that methyl-CpG binding protein 2 (Mecp2) expression is cell cycle-dependent and negatively regulates quiescence exit in cultured cells and in an injury-induced liver regeneration mouse model.
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PMC11247842
The filtered data showed no genomic inflation in any of the studies (see Additional file 1: Table S4 and Additional file 2: Figure S2).
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PMC9509578
Thermal, magnetic and light-based nanosystems have recently been identified for efficient reversal of drug resistance.
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PMC9429973
During 1 lockdown only 58 diagnoses were captured (Q1 2020/21 – 72% of the Spring/Summer average).
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PMC9960565
The low-intensity signal obtained in the ¹⁹⁵Pt-NMR experiment was due to the sensitivity of the NMR probe used for the ¹⁹⁵Pt-nucleus.
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PMC10094712
First of all, this is due to the difficulties in obtaining native forms of selenoproteins in preparative quantities, due to the fact that the amino acid selenocysteine is encoded by one of the three stop codons of the TGA universal genetic code.
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PMC11467964
Subsequently, we screened out two molecular subtypes by consensus clustering based on all BMRGs expression.
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