OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC8973085	calcd for C30H24F2N4O4S: C, 62.71; H, 4.21; N, 9.75.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "calcd", "for", "C30H24F2N4O4S", ":", "C", ",", "62.71", ...
PMC10006224	In vitro, NIPBL is also required both for topological entrapment of plasmid DNA and for loop extrusion by cohesin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "vitro", ",", "NI...
PMC11640247	To date, 12 de novo missense variants in RAC3 have been associated with a clinically heterogeneous disorder known as NEurodevelopmental Disorder with Brain Anomalies and dysmorphic Facies (NEDBAF, MIM #618577) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC3734024	Reciprocally, the frequency of FasL cells among all B cells and CD5CD1d B cells was measured.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Reciprocally", ",", "the", "frequency", "of", ...
PMC11155445	Crystal packing of the molecules crystal was stabilized by intramolecular CO⋯H–N hydrogen bond and intermolecular CS⋯H–N and CS⋯H–C hydrogen interactions (Fig. 6).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11718031	IS CHO-CD G17.4 and IS CHO-CDG17.7, two top-performing media from the batch culture study in terms of VCC and titer, showed a marginal increase in the VCC with all the tested media-feed combinations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Image: Summary/Conclusion: Our findings indicate that PET has insufficient sensitivity for detection of BM involvement for baseline staging.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Image", ":", "Summary/Conclu...
PMC11394730	It is fully soluble in ethanol or dimethyl sulfoxide but only partially soluble in water.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "is", "fully", "soluble", "in", "ethanol", "or", ...
PMC6901583	b GIST882 and GIST-T1 cells stably expressing vector or BRD4 were cultured with DMEM without serum overnight.	[ { "tags": [ "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "b", "GIST882", "and", "GIST-T1", ...
PMC11756937	By the second passage post-recovery, one well of the six-well plate was submitted for mycoplasma detection by placing 0.5 mL spent medium and 0.5 mL cell suspension into a mycoplasma test glass vial.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11342785	For a MT bundling assay, TPPP variants and TPPP chimeras were incubated with Taxol-stabilized, Alexa Fluor 594-labeled and biotin-labeled tubulin MTs for 5 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11001582	Genotypes: w; GMR-Gal4/+, w; GMR-Gal4/UAS-daw RNAi, w; GMR-Gal4/UAS-Mp RNAi, w; GMR-Gal4, UAS-GR36/+, w; GMR-Gal4, UAS-GR36/UAS-daw RNAi, w; GMR-Gal4, UAS-GR36/UAS-Mp RNAi.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11756907	The cytotoxicity results of the GO-2ME and rGO-2ME in the graphs (Figure 2B and D) were also correlated with the cytotoxicity values of the 2-ME in DMSO.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11468365	The GCN model utilizes an effective layer-wise propagation mechanism.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "GCN", "model", "utilizes", "an", "effective", "layer-wise", "propagation", "mechanism", "." ] ...
PMC10761571	: Zeta potential of Fe3O4@Glu-Gingerol, (b): Zeta potential of Fe3O4 NP, (c): DLS analysis of Fe3O4@Glu-Gingerol and (d): DLS analysis of Fe3O4 NP.Fig.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Given the associated mortality and morbidity, we recommend considering a hematological consult for IBD patients with leukocytosis or leukopenia for further evaluation and appropriate management.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC10125312	High temperatures impaired mitochondrial activity, reducing the viability of the cell lines drastically, occasionally down to 50% immediately after treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "High", ...
PMC11322866	The cells were then rinsed three times with 0.1 M sulfuric acid buffer (pH 7.4) for 15 min each time, fixed with 1% osmic acid+ 0.1 M sulfuric acid buffer (pH 7.4) at 20°C for 2 h, and rinsed three times with 0.1 M phosphate buffer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9952933	The production of hydrogen peroxide by CAP was investigated by treating both cell culture media with CAP for up to 40 s. A treatment time-dependent formation of hydrogen peroxide was found.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Tumor response was assessed by independent central review according to Lugano 2014 response criteria.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Tumor", "response", "was", "assessed", "by", "independent", "central",...
PMC8358006	ESCC is a common malignancy without effective therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ESCC", "is", "a", "common", "malignancy", "without", "effective", "therapy", "." ] } ]
PMC11474209	Additionally, mitochondria cause inflammation and irreversible genomic and epigenetic alterations, which, together with other factors, contribute to developing degenerative diseases such as cancer .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11742864	DHA triggered apoptosis in neoplastic cells via increasing ROS production through the downregulation of catalase, while the antioxidant NAC reversed DHA’s effects.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	The study recruited adult patients with previously untreated cHL.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "study", "recruited", "adult", "patients", "with", "previously", "untreated", "cHL", "." ] } ]
PMC11457557	In 1998, the first linkage studies for DKD were performed on Pima Indians, showing a strong association to chromosome 3q24 .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "1998",...
PMC11257203	However, the use of other genotoxicity testing techniques such as the Comet assay, measuring the amount of other oxidative stress factors such as ROS can help a better understanding of the molecular mechanisms involved.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Median follow – up was 98 months for LDFCR and 57 months for BR.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Median", "follow", "–", "up", "was", "98", "months", "for", ...
PMC10772747	In addition, P53 also inhibits the expression of the Bcl-2 gene, which is a member of the anti-apoptotic protein family.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "additi...
PMC11790599	All cells were cultured in a humidified incubator with 5% CO2 at 37°C and routinely tested for mycoplasma by a PCR-based method (Young et al., 2010).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC2196094	RMCP-8, -9, and 10 are all highly homologous and may be regarded as a new subfamily of MC proteases, more closely related to the T cell granzymes than to the previously characterised MC proteases (see Fig. 6).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9985266	P < 0.05, P < 0.01, *P < 0.001; values are expressed as the mean ± standard deviation (n = 3) IL-27 upregulates MEG3 expression by inhibiting DNMT1-mediated methylation of the MEG3 promoter.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11538390	from nine replicates of cells harboring each genotype, as indicated in the plot.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "from", "nine", "replicates", "of", "cells", "harboring", "each", ...
PMC11591052	STRING-based analysis of the up-regulated genes revealed the significantly enriched protein–protein interaction (PPI) network (PPI enrichment p-value: < 1.0 × 10), which includes genes involved in cellular metabolic processes (large sets of genes involved in oxidative phosphorylation and cellular biosynthetic processes), translation, and response to stress (Figure 2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11473750	Thus, RNF121 expression patterns and ploidy define a very high-risk subgroup of neuroblastoma patients, especially if present with MYCN amplification.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thus", ",", ...
PMC11759543	Isolated tumor picture.	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "Isolated", "tumor", "picture", "." ] } ]
PMC9429973	Aims: Here we report a critical role for the conserved amino-acid proline at position 199, at the 3’ end of the PNT domain, for ERG’s leukemogenic activity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8524093	Results demonstrated that Vero-E6, BHK-21, and C6/36 are more susceptible to CHIKV and produced higher viral titer than RD and A-549 cells (Sudeep et al., 2019).	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", ...
PMC10940855	All other ECs were purchased from ATCC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "other", "ECs", "were", "purchased", "from", "ATCC", "." ] } ]
PMC11770746	A2780 human ovarian carcinoma cells and A2780cisR cisplatin-resistant ovarian carcinoma cells were cultured in RPMI 1640 (no glutamine) supplemented with heat-inactivated fetal bovine serum (South American origin) (10% v/v), gentamycin sulfate solution (1% v/v), and l-glutamine solution 2 mM (1% v/v).	[ { "tags": [ "B-CellLine", "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10999934	Within the GSE158937 dataset, it was observed that FBXO2 expression was elevated in malignant epithelial cells associated with chemoresistance, as opposed to those not related to chemoresistance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11033180	The signals underwent digitization at a rate of 1 kHz.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "signals", "underwent", "digitization", "at", "a", "rate", "of", "1", "kHz", "." ...
PMC4369959	Further they found that 6-gingerol decreased both cyclin A and cyclin-dependent kinase (Cdk) expression followed by reduction in retinoblastoma (Rb) phosphorylation and blocking of S phase entry .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11269933	The In vivo phosphorylation assay (J), in Vivo PK activity assay (n = 3; K), PA content ratio (n = 3; L) and ATP content ratio (n = 3; M) of HEK293T cells transfected with Flag-CgPk and Myc-CgErk1/2 after incubating with ERK inhibitor (SCH772984) for 8 h. All data are presented in the form of mean ± SD.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11487720	UV/cold shock-treated cells failed to migrate due, in part, to drastic loss of α-tubulin and cortactin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "UV/cold", "shock-treated", "cells", "failed"...
PMC11680562	Examining texture and homogeneity included applying gentle pressure to a tiny quantity of the gels using the thumb and index finger.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Examining", "texture", ...
PMC11512230	SP from TMV at a concentration of 0.1 mg/mL were obtained according to .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "SP", "from", "TMV", "at", "a", "concentration", "of", "0.1", "mg/mL",...
PMC8358006	The shRNA sequences targeting TBX20 were as follows: sh1, ACAACAAGAGGTACCGCTA and sh2, TCAAACAGATGGTGTCTTT.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "shRNA", "sequences", "targeting", "TBX20", "wer...
PMC8481254	Scale bar, 500 μm.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", ",", "500", "μm", "." ] } ]
PMC3888431	If transcripts from different cluster mapped on the same gene locus, the transcripts where counted as “multiple cluster”.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "If", "transcripts", ...
PMC11670954	The primer sets utilized are listed in Table 2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "primer", "sets", "utilized", "are", "listed", "in", "Table", "2", "." ] } ]
PMC11451829	Our results provide evidence to support the idea that, in our model, the pterygium-like lesion between days 7 and 15 allows the evaluation of surgical treatments and therapeutic agents against inflammatory and vascular components.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11783017	As for the treatment with Lipo-IL11 alone, it did not affect extracellular ATP level (Fig. 4L).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "for", "the", "treatment", ...
PMC9275501	Several factors could be associated with drug resistance in cancer such as overexpression of P-glycoprotein (P-gp), cancer stem cells (CSCs), defect in apoptosis, mutation and alteration in DNA repair pathways, angiogenesis, autophagy, and modulation in metabolic enzymes (Mohammad et al., 2020).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10073922	per 1×10 cells and the RNAs were extracted according to the manufacturer's protocol.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "per", "1", "×", "10", "cells", "and", "the", ...
PMC9429973	Results: 32 patients were reported: 41% male, 59% female.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "32", "patients", "were", "reported", ":", "41", ...
PMC10606998	Accordingly, the probability of damage by this short-range secondary radiation of the cell vital structures and the cell death increases when nanoparticles are absorbed by the cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11701801	For all experiments, P values were determined by an unpaired two-tailed Student t test. *,	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "all", "experiments", ",", "P", "valu...
PMC8567602	To explore the transcriptional impact of Smarcb1 genetic silencing, SS18–SSX expression, or the combination of the two in mice, RNA sequencing (RNA-seq) was performed for mouse tumors with either presence or absence of heterozygosity for hSS2 and wild-type or homozygous floxed alleles of Smarcb1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10873328	In summary, the HRGs prognosis risk classifier could be served as a predictor for OC prognosis and efficacy evaluation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "summary", ",", "...
PMC11694625	During the synthesis process, the reaction process was monitored by thin layer chromatography.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "During", "the", "synthesis", "process", ",", "the", "reaction", ...
PMC9429973	Aims: The primary objective was to estimate the maximum tolerated dose (MTD) of InO when added to DA-EPOCH.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ":", "The"...
PMC11627060	Amide II reflects a combination of N–H in-plane bending and C–N stretching vibrations .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Amide", "II", "reflects", "a", "combination", ...
PMC9429973	Transplantation from HID or ISD SCT has greatly improved quality of life (QoL) levels post-HSCT compared to pre-HSCT.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Transplantation", "from", "H...
PMC9429973	Supported by MHCR (00023736, IHBT).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Supported", "by", "MHCR", "(", "00023736", ",", "IHBT", ")", "." ] } ]
PMC11791478	Statistical analyses were performed using Prism (GraphPad) software (version 5.01) unless specified otherwise.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Statistical", "analyses", "were", "performed", "u...
PMC9429973	These data support that RKER-050 may be promoting MK maturation and the terminal stages of thrombopoiesis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "data", "support", "that", "RKER-050", "may", ...
PMC9429973	Some of them demonstrate anti-tumor properties (e.g. miR-34), others are associated with the enhancing of the tumor growth (e.g. miR-21), therefore being prospective effectors and targets for the gene therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11507371	CAP has been shown to be effective in anti-septic and anti-inflammatory applications as well as in promoting cell proliferation and tissue regeneration due to the generation of reactive oxygen and nitrogen species (RONS).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11723947	HP1 is conserved through evolution, with homologs found from fission yeast to mammals.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HP1", "is", "conserved", "through", "evolution", ",", "with", "h...
PMC9872547	Protein bands were detected with the enhanced chemiluminescence (ECL) method (Biomedical Company).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Protein", "bands", "were", "detected", "with", "the", ...
PMC11648299	While previous investigations suggest that the estimated prevalence of DD is between 1/30,000 to 1/100,000 , our recent study using the ICD-10-SE and NPR has shown that DD is more common than previously estimated, with a prevalence of 1/12,000 in Sweden .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11758416	We thank the Center for Cellular Profiling at BWH and Junning Case for assistance in cell sorting and flow cytometry.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "thank", "the", "...
PMC11585994	The G5-sgc8-siBCL11B nanoparticle system demonstrated efficient delivery and significant therapeutic efficacy, highlighting its potential as a promising novel approach for the treatment of T-ALL.T-cell acute lymphoblastic leukemia is a highly aggressive leukemia with poor prognosis.1–5 Compared to B-cell acute lymphoblastic leukemia (B-ALL), T-ALL is characterized by high tumor heterogeneity and a lack of well-defined therapeutic targets.6–9 Due to the dysregulated differentiation and uncontrolled proliferation typical of T-ALL, our study focused on BCL11B, a critical regulator of T-cell differentiation involved in multiple pathways during T-cell maturation and differentiation.10–12 BCL11B is essential for T-cell lineage commitment and plays a crucial role in directing the differentiation of hematopoietic stem cells into T-cells instead of natural killer cells.13,14 However, mutations in BCL11B or its fusion with other genes have been implicated in the development of T-ALL and acute myeloid leukemia (AML).15 Our research, along with findings from other studies, indicates that BCL11B is expressed at higher levels in T-ALL cells compared to normal T-cells, potentially contributing to the inhibition of apoptotic signaling pathways.16,17 Moreover, reducing the BCL11B level has been demonstrated to promote apoptosis and inhibit the growth of T-ALL cells.18–21 Furthermore, research also demonstrated that demonstrated that knocking down BCL11B in normal T-cells had minimal impact on T-cell differentiation and proliferation.22 Based on this evidence, we hypothesize that targeting BCL11B may offer a promising therapeutic approach for treating T-ALL.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11342785	F, inducible synMAP circuits (TPPP-DDX4 design) can nucleate microtubule aster formation following nocodazole treatment as shown in (E). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9221284	The only c-Myc protein that will be produced if this Trans2 is translated in vivo will be c-MycS. This hypothesis is in agreement with our Western blot data.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11594806	These results support prior analyses indicating the involvement of the CD73 pathway in CDDP treatment response .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "results", "support", "prior", "analyses", "in...
PMC4005030	In carbon tetrachloride (CCL4) induced rat liver fibrosis model, liver fibrosis grade, and histopathological changes were evaluated, and biochemical indicators were determined.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11632064	Occasionally, cell suspensions were centrifuged at 1,000g for 5 min and resuspended in a smaller volume of culture medium.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Occasionally", ",", ...
PMC11806106	Especially the outbreak of the recent opioid crisis in the US showed that the application of opioids is accompanied by a high risk for abuse and overdose, with more than 80.000 deaths caused by opioid overdose in 2021 alone.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11546117	PMC42-LA cells were expanded at a density of 1 × 10 cells/cm in normal cell culture flasks (CELLSTAR).	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PMC42-LA", "cells", ...
PMC7887261	The percentage of γH2AX positive cells in each sample was calculated and compared to its corresponding non-targeting siRNA control.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "percentage", "of", "γH2AX"...
PMC9429973	Patient, disease and treatment characteristics were reviewed through hospital electronic health records.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Patient", ",", "disease", "and", "treatment", "characteristics", "were", "r...
PMC11766309	KEGG analysis indicated that YKT6 positively regulates pathways associated with neurodegeneration, amyotrophic lateral sclerosis, and amyotrophic lateral sclerosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "KEGG", "analysis", "indicate...
PMC9368503	It typically arises in adolescents and young adults although can affect patients of any age .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "typically", "arises", "in", "adolescents", "and", "yo...
PMC9429973	A. H. Wei, H. E. Carraway, L. Taningco, E. Laille, J. Gong, T. Prebet, D. Lopes de Menezes, F. Ravandi Department of Clinical Haematology, Alfred Hospital, and the Australian Centre for Blood Diseases, Monash University, Melbourne, Australia; Leukemia Program, Taussig Cancer Institute, Cleveland Clinic, Cleveland; Bristol Myers Squibb, Princeton; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, United States of America Background: For older patients (pts) with acute myeloid leukemia (AML) who are ineligible for standard intensive chemotherapy (IC) regimens, traditional lower-intensity AML treatment (Tx) options include low-dose cytarabine (LDAC) or hypomethylating agents (HMAs; azacitidine [AZA] and decitabine), which are generally well tolerated but associated with suboptimal outcomes vs IC [Vey 2020].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11190062	Several of the new immune therapeutic drugs approved to treat relapsed or refractory MM are targeting BCMA on the myeloma cells (36).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9622879	In this SMG, there was the SMG operator which controlled all communal DERs and different types of loads, consisting of shiftable load, curtailable load, and fixed load.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11045125	Results are presented as the ratio of Myb, Myc, CD179B, Cyclin D3, UHRF1, Rag1, and DNMT3B expression in Myb knockdown (or Myb over-expression) conditions relative to control conditions after being normalized to actin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11012313	Normalized RNA amounts were then reverse transcribed to cDNA and qPCR for each sample was performed in triplicate to ensure accuracy of the results using the Quantstudio™ 5 Real-time PCR machine.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7757104	However, the specific mechanisms by which OPNc may favor chemoresistance are currently unknown.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "the", "specific", "mechanisms", "by", "which", "...
PMC11545737	Pralnacasan was tested for rheumatoid arthritis but showed high liver toxicity in mice at high doses .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Pralnacasan", "was", "tested", "for", "rheumatoid", "a...
PMC8316344	AA and AdA in the membrane fractions were measured in Bel-7404 cells with TRIB2 knocked out with or without reconstitution of TRIB2 (A, C), and in SK-Hep1 cells with or without TRIB2 overexpression (B, D) in basal condition or following treating with RSL3 (5 µM, 12 h) or erastin (10 µM, 12 h).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Ten patients with CR were vaccinated against coronavirus infection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Ten", "patients", "with", "CR", "were", "vaccinated", "against", "coronavirus", "infection", "." ] } ...
PMC8140214	Results are given as mean±SD (n=4). *	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", "are", "given", "as", "mean±SD", "(", "n=4", ")", ".", "*" ] } ]
PMC10747160	However, because it can undergo spontaneous oxidation at Methionine 78, it is typical to mutate M78 to Glutamine in order to create a shelf-stable therapeutic that is compliant with FDA bylaws .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10698968	A Summary of clinical data of the patient (top), Sag T2 FAT Sat MRI of the forearm shows the recurred tumour mass (bottom left), while Sag T2 FAT Sat MRI of the spine (bottom right) shows multiple hyperintense metastatic lesions (blue arrows) with a pathological fracture in T6 (red arrow).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	He was also presented with cognitive defects and neurologic disorders.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "He", "was", "also", "presented", "with", "cognitive", "defects", "and", "neurologic", "disorders...
PMC10317042	Furthermore, we identify another drug for enhancing EWSR1::ATF1 suppression in CCS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "we", "identify", "another", "drug", "for", "enhancing", "EWS...
PMC11474209	CaMKII activation by caspases may also control downstream events, including ROS generation and protein phosphorylation like myosin light chain (MLC).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CaMKII"...
PMC10142392	In addition to the expected esterase degradation, there is also evidence of PCL sensitivity to enzymatic degradation by lipases .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", "to", ...

PMC8973085

calcd for C30H24F2N4O4S: C, 62.71; H, 4.21; N, 9.75.

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PMC10006224

In vitro, NIPBL is also required both for topological entrapment of plasmid DNA and for loop extrusion by cohesin.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "vitro", ",", "NI...

PMC11640247

To date, 12 de novo missense variants in RAC3 have been associated with a clinically heterogeneous disorder known as NEurodevelopmental Disorder with Brain Anomalies and dysmorphic Facies (NEDBAF, MIM #618577) .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC3734024

Reciprocally, the frequency of FasL cells among all B cells and CD5CD1d B cells was measured.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Reciprocally", ",", "the", "frequency", "of", ...

PMC11155445

Crystal packing of the molecules crystal was stabilized by intramolecular CO⋯H–N hydrogen bond and intermolecular CS⋯H–N and CS⋯H–C hydrogen interactions (Fig. 6).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11718031

IS CHO-CD G17.4 and IS CHO-CDG17.7, two top-performing media from the batch culture study in terms of VCC and titer, showed a marginal increase in the VCC with all the tested media-feed combinations.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Image: Summary/Conclusion: Our findings indicate that PET has insufficient sensitivity for detection of BM involvement for baseline staging.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Image", ":", "Summary/Conclu...

PMC11394730

It is fully soluble in ethanol or dimethyl sulfoxide but only partially soluble in water.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "is", "fully", "soluble", "in", "ethanol", "or", ...

PMC6901583

b GIST882 and GIST-T1 cells stably expressing vector or BRD4 were cultured with DMEM without serum overnight.

[ { "tags": [ "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "b", "GIST882", "and", "GIST-T1", ...

PMC11756937

By the second passage post-recovery, one well of the six-well plate was submitted for mycoplasma detection by placing 0.5 mL spent medium and 0.5 mL cell suspension into a mycoplasma test glass vial.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11342785

For a MT bundling assay, TPPP variants and TPPP chimeras were incubated with Taxol-stabilized, Alexa Fluor 594-labeled and biotin-labeled tubulin MTs for 5 min.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC11001582

Genotypes: w; GMR-Gal4/+, w; GMR-Gal4/UAS-daw RNAi, w; GMR-Gal4/UAS-Mp RNAi, w; GMR-Gal4, UAS-GR36/+, w; GMR-Gal4, UAS-GR36/UAS-daw RNAi, w; GMR-Gal4, UAS-GR36/UAS-Mp RNAi.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11756907

The cytotoxicity results of the GO-2ME and rGO-2ME in the graphs (Figure 2B and D) were also correlated with the cytotoxicity values of the 2-ME in DMSO.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11468365

The GCN model utilizes an effective layer-wise propagation mechanism.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "GCN", "model", "utilizes", "an", "effective", "layer-wise", "propagation", "mechanism", "." ] ...

PMC10761571

: Zeta potential of Fe3O4@Glu-Gingerol, (b): Zeta potential of Fe3O4 NP, (c): DLS analysis of Fe3O4@Glu-Gingerol and (d): DLS analysis of Fe3O4 NP.Fig.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Given the associated mortality and morbidity, we recommend considering a hematological consult for IBD patients with leukocytosis or leukopenia for further evaluation and appropriate management.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC10125312

High temperatures impaired mitochondrial activity, reducing the viability of the cell lines drastically, occasionally down to 50% immediately after treatment.

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PMC11322866

The cells were then rinsed three times with 0.1 M sulfuric acid buffer (pH 7.4) for 15 min each time, fixed with 1% osmic acid+ 0.1 M sulfuric acid buffer (pH 7.4) at 20°C for 2 h, and rinsed three times with 0.1 M phosphate buffer.

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PMC9952933

The production of hydrogen peroxide by CAP was investigated by treating both cell culture media with CAP for up to 40 s. A treatment time-dependent formation of hydrogen peroxide was found.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Tumor response was assessed by independent central review according to Lugano 2014 response criteria.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Tumor", "response", "was", "assessed", "by", "independent", "central",...

PMC8358006

ESCC is a common malignancy without effective therapy.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ESCC", "is", "a", "common", "malignancy", "without", "effective", "therapy", "." ] } ]

PMC11474209

Additionally, mitochondria cause inflammation and irreversible genomic and epigenetic alterations, which, together with other factors, contribute to developing degenerative diseases such as cancer .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11742864

DHA triggered apoptosis in neoplastic cells via increasing ROS production through the downregulation of catalase, while the antioxidant NAC reversed DHA’s effects.

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PMC9429973

The study recruited adult patients with previously untreated cHL.

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PMC11457557

In 1998, the first linkage studies for DKD were performed on Pima Indians, showing a strong association to chromosome 3q24 .

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PMC11257203

However, the use of other genotoxicity testing techniques such as the Comet assay, measuring the amount of other oxidative stress factors such as ROS can help a better understanding of the molecular mechanisms involved.

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PMC9429973

Median follow – up was 98 months for LDFCR and 57 months for BR.

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PMC10772747

In addition, P53 also inhibits the expression of the Bcl-2 gene, which is a member of the anti-apoptotic protein family.

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PMC11790599

All cells were cultured in a humidified incubator with 5% CO2 at 37°C and routinely tested for mycoplasma by a PCR-based method (Young et al., 2010).

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PMC2196094

RMCP-8, -9, and 10 are all highly homologous and may be regarded as a new subfamily of MC proteases, more closely related to the T cell granzymes than to the previously characterised MC proteases (see Fig. 6).

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PMC9985266

P < 0.05, **P < 0.01, ***P < 0.001; values are expressed as the mean ± standard deviation (n = 3) IL-27 upregulates MEG3 expression by inhibiting DNMT1-mediated methylation of the MEG3 promoter.

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PMC11538390

from nine replicates of cells harboring each genotype, as indicated in the plot.

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PMC11591052

STRING-based analysis of the up-regulated genes revealed the significantly enriched protein–protein interaction (PPI) network (PPI enrichment p-value: < 1.0 × 10), which includes genes involved in cellular metabolic processes (large sets of genes involved in oxidative phosphorylation and cellular biosynthetic processes), translation, and response to stress (Figure 2).

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PMC11473750

Thus, RNF121 expression patterns and ploidy define a very high-risk subgroup of neuroblastoma patients, especially if present with MYCN amplification.

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PMC11759543

Isolated tumor picture.

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PMC9429973

Aims: Here we report a critical role for the conserved amino-acid proline at position 199, at the 3’ end of the PNT domain, for ERG’s leukemogenic activity.

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PMC8524093

Results demonstrated that Vero-E6, BHK-21, and C6/36 are more susceptible to CHIKV and produced higher viral titer than RD and A-549 cells (Sudeep et al., 2019).

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PMC10940855

All other ECs were purchased from ATCC.

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PMC11770746

A2780 human ovarian carcinoma cells and A2780cisR cisplatin-resistant ovarian carcinoma cells were cultured in RPMI 1640 (no glutamine) supplemented with heat-inactivated fetal bovine serum (South American origin) (10% v/v), gentamycin sulfate solution (1% v/v), and l-glutamine solution 2 mM (1% v/v).

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PMC10999934

Within the GSE158937 dataset, it was observed that FBXO2 expression was elevated in malignant epithelial cells associated with chemoresistance, as opposed to those not related to chemoresistance.

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PMC11033180

The signals underwent digitization at a rate of 1 kHz.

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PMC4369959

Further they found that 6-gingerol decreased both cyclin A and cyclin-dependent kinase (Cdk) expression followed by reduction in retinoblastoma (Rb) phosphorylation and blocking of S phase entry .

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PMC11269933

The In vivo phosphorylation assay (J), in Vivo PK activity assay (n = 3; K), PA content ratio (n = 3; L) and ATP content ratio (n = 3; M) of HEK293T cells transfected with Flag-CgPk and Myc-CgErk1/2 after incubating with ERK inhibitor (SCH772984) for 8 h. All data are presented in the form of mean ± SD.

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PMC11487720

UV/cold shock-treated cells failed to migrate due, in part, to drastic loss of α-tubulin and cortactin.

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PMC11680562

Examining texture and homogeneity included applying gentle pressure to a tiny quantity of the gels using the thumb and index finger.

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PMC11512230

SP from TMV at a concentration of 0.1 mg/mL were obtained according to .

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PMC8358006

The shRNA sequences targeting TBX20 were as follows: sh1, ACAACAAGAGGTACCGCTA and sh2, TCAAACAGATGGTGTCTTT.

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PMC8481254

Scale bar, 500 μm.

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PMC3888431

If transcripts from different cluster mapped on the same gene locus, the transcripts where counted as “multiple cluster”.

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PMC11670954

The primer sets utilized are listed in Table 2.

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PMC11451829

Our results provide evidence to support the idea that, in our model, the pterygium-like lesion between days 7 and 15 allows the evaluation of surgical treatments and therapeutic agents against inflammatory and vascular components.

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PMC11783017

As for the treatment with Lipo-IL11 alone, it did not affect extracellular ATP level (Fig. 4L).

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PMC9275501

Several factors could be associated with drug resistance in cancer such as overexpression of P-glycoprotein (P-gp), cancer stem cells (CSCs), defect in apoptosis, mutation and alteration in DNA repair pathways, angiogenesis, autophagy, and modulation in metabolic enzymes (Mohammad et al., 2020).

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PMC10073922

per 1×10 cells and the RNAs were extracted according to the manufacturer's protocol.

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PMC9429973

Results: 32 patients were reported: 41% male, 59% female.

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PMC10606998

Accordingly, the probability of damage by this short-range secondary radiation of the cell vital structures and the cell death increases when nanoparticles are absorbed by the cells.

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PMC11701801

For all experiments, P values were determined by an unpaired two-tailed Student t test. *,

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PMC8567602

To explore the transcriptional impact of Smarcb1 genetic silencing, SS18–SSX expression, or the combination of the two in mice, RNA sequencing (RNA-seq) was performed for mouse tumors with either presence or absence of heterozygosity for hSS2 and wild-type or homozygous floxed alleles of Smarcb1.

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PMC10873328

In summary, the HRGs prognosis risk classifier could be served as a predictor for OC prognosis and efficacy evaluation.

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PMC11694625

During the synthesis process, the reaction process was monitored by thin layer chromatography.

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PMC9429973

Aims: The primary objective was to estimate the maximum tolerated dose (MTD) of InO when added to DA-EPOCH.

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PMC11627060

Amide II reflects a combination of N–H in-plane bending and C–N stretching vibrations .

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PMC9429973

Transplantation from HID or ISD SCT has greatly improved quality of life (QoL) levels post-HSCT compared to pre-HSCT.

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PMC9429973

Supported by MHCR (00023736, IHBT).

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PMC11791478

Statistical analyses were performed using Prism (GraphPad) software (version 5.01) unless specified otherwise.

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PMC9429973

These data support that RKER-050 may be promoting MK maturation and the terminal stages of thrombopoiesis.

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PMC9429973

Some of them demonstrate anti-tumor properties (e.g. miR-34), others are associated with the enhancing of the tumor growth (e.g. miR-21), therefore being prospective effectors and targets for the gene therapy.

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PMC11507371

CAP has been shown to be effective in anti-septic and anti-inflammatory applications as well as in promoting cell proliferation and tissue regeneration due to the generation of reactive oxygen and nitrogen species (RONS).

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PMC11723947

HP1 is conserved through evolution, with homologs found from fission yeast to mammals.

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PMC9872547

Protein bands were detected with the enhanced chemiluminescence (ECL) method (Biomedical Company).

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PMC11648299

While previous investigations suggest that the estimated prevalence of DD is between 1/30,000 to 1/100,000 , our recent study using the ICD-10-SE and NPR has shown that DD is more common than previously estimated, with a prevalence of 1/12,000 in Sweden .

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PMC11758416

We thank the Center for Cellular Profiling at BWH and Junning Case for assistance in cell sorting and flow cytometry.

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PMC11585994

The G5-sgc8-siBCL11B nanoparticle system demonstrated efficient delivery and significant therapeutic efficacy, highlighting its potential as a promising novel approach for the treatment of T-ALL.T-cell acute lymphoblastic leukemia is a highly aggressive leukemia with poor prognosis.1–5 Compared to B-cell acute lymphoblastic leukemia (B-ALL), T-ALL is characterized by high tumor heterogeneity and a lack of well-defined therapeutic targets.6–9 Due to the dysregulated differentiation and uncontrolled proliferation typical of T-ALL, our study focused on BCL11B, a critical regulator of T-cell differentiation involved in multiple pathways during T-cell maturation and differentiation.10–12 BCL11B is essential for T-cell lineage commitment and plays a crucial role in directing the differentiation of hematopoietic stem cells into T-cells instead of natural killer cells.13,14 However, mutations in BCL11B or its fusion with other genes have been implicated in the development of T-ALL and acute myeloid leukemia (AML).15 Our research, along with findings from other studies, indicates that BCL11B is expressed at higher levels in T-ALL cells compared to normal T-cells, potentially contributing to the inhibition of apoptotic signaling pathways.16,17 Moreover, reducing the BCL11B level has been demonstrated to promote apoptosis and inhibit the growth of T-ALL cells.18–21 Furthermore, research also demonstrated that demonstrated that knocking down BCL11B in normal T-cells had minimal impact on T-cell differentiation and proliferation.22 Based on this evidence, we hypothesize that targeting BCL11B may offer a promising therapeutic approach for treating T-ALL.

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PMC11342785

F, inducible synMAP circuits (TPPP-DDX4 design) can nucleate microtubule aster formation following nocodazole treatment as shown in (E). (

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PMC9221284

The only c-Myc protein that will be produced if this Trans2 is translated in vivo will be c-MycS. This hypothesis is in agreement with our Western blot data.

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PMC11594806

These results support prior analyses indicating the involvement of the CD73 pathway in CDDP treatment response .

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PMC4005030

In carbon tetrachloride (CCL4) induced rat liver fibrosis model, liver fibrosis grade, and histopathological changes were evaluated, and biochemical indicators were determined.

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PMC11632064

Occasionally, cell suspensions were centrifuged at 1,000g for 5 min and resuspended in a smaller volume of culture medium.

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PMC11806106

Especially the outbreak of the recent opioid crisis in the US showed that the application of opioids is accompanied by a high risk for abuse and overdose, with more than 80.000 deaths caused by opioid overdose in 2021 alone.

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PMC11546117

PMC42-LA cells were expanded at a density of 1 × 10 cells/cm in normal cell culture flasks (CELLSTAR).

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PMC7887261

The percentage of γH2AX positive cells in each sample was calculated and compared to its corresponding non-targeting siRNA control.

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PMC9429973

Patient, disease and treatment characteristics were reviewed through hospital electronic health records.

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PMC11766309

KEGG analysis indicated that YKT6 positively regulates pathways associated with neurodegeneration, amyotrophic lateral sclerosis, and amyotrophic lateral sclerosis.

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PMC9368503

It typically arises in adolescents and young adults although can affect patients of any age .

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PMC9429973

A. H. Wei, H. E. Carraway, L. Taningco, E. Laille, J. Gong, T. Prebet, D. Lopes de Menezes, F. Ravandi Department of Clinical Haematology, Alfred Hospital, and the Australian Centre for Blood Diseases, Monash University, Melbourne, Australia; Leukemia Program, Taussig Cancer Institute, Cleveland Clinic, Cleveland; Bristol Myers Squibb, Princeton; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, United States of America Background: For older patients (pts) with acute myeloid leukemia (AML) who are ineligible for standard intensive chemotherapy (IC) regimens, traditional lower-intensity AML treatment (Tx) options include low-dose cytarabine (LDAC) or hypomethylating agents (HMAs; azacitidine [AZA] and decitabine), which are generally well tolerated but associated with suboptimal outcomes vs IC [Vey 2020].

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PMC11190062

Several of the new immune therapeutic drugs approved to treat relapsed or refractory MM are targeting BCMA on the myeloma cells (36).

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PMC9622879

In this SMG, there was the SMG operator which controlled all communal DERs and different types of loads, consisting of shiftable load, curtailable load, and fixed load.

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PMC11045125

Results are presented as the ratio of Myb, Myc, CD179B, Cyclin D3, UHRF1, Rag1, and DNMT3B expression in Myb knockdown (or Myb over-expression) conditions relative to control conditions after being normalized to actin.

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PMC11012313

Normalized RNA amounts were then reverse transcribed to cDNA and qPCR for each sample was performed in triplicate to ensure accuracy of the results using the Quantstudio™ 5 Real-time PCR machine.

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PMC7757104

However, the specific mechanisms by which OPNc may favor chemoresistance are currently unknown.

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PMC11545737

Pralnacasan was tested for rheumatoid arthritis but showed high liver toxicity in mice at high doses .

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PMC8316344

AA and AdA in the membrane fractions were measured in Bel-7404 cells with TRIB2 knocked out with or without reconstitution of TRIB2 (A, C), and in SK-Hep1 cells with or without TRIB2 overexpression (B, D) in basal condition or following treating with RSL3 (5 µM, 12 h) or erastin (10 µM, 12 h).

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PMC9429973

Ten patients with CR were vaccinated against coronavirus infection.

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PMC8140214

Results are given as mean±SD (n=4). *

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PMC10747160

However, because it can undergo spontaneous oxidation at Methionine 78, it is typical to mutate M78 to Glutamine in order to create a shelf-stable therapeutic that is compliant with FDA bylaws .

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PMC10698968

A Summary of clinical data of the patient (top), Sag T2 FAT Sat MRI of the forearm shows the recurred tumour mass (bottom left), while Sag T2 FAT Sat MRI of the spine (bottom right) shows multiple hyperintense metastatic lesions (blue arrows) with a pathological fracture in T6 (red arrow).

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PMC9429973

He was also presented with cognitive defects and neurologic disorders.

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PMC10317042

Furthermore, we identify another drug for enhancing EWSR1::ATF1 suppression in CCS.

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PMC11474209

CaMKII activation by caspases may also control downstream events, including ROS generation and protein phosphorylation like myosin light chain (MLC).

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PMC10142392

In addition to the expected esterase degradation, there is also evidence of PCL sensitivity to enzymatic degradation by lipases .

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