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OTAR3088
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BioData-CellLine_annotated

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PMC9429973
Thrombotic event was documented in 1 patient.
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PMC8750422
As expected, GPR87 suppression markedly increased the expression of the epithelial cell markers E-cadherin and claudin (Figure 2c,d and Figure S2b).
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PMC11742231
For a given fingerprint F, let’s denote F as a matrix with dimensions (M, K), where M is the number of features (e.g., the number of features) and K is the number of features per cell line.
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PMC10887351
Since β3-AR antagonism led to massive cell death, blocking β3-AR in A673 cells could significantly increase the ROS levels by the toxic limit, resulting in cell death.
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PMC4277423
But our unexpected results in primary T cells serve as a cautionary warning for researchers like us who are interested in developing the CRISPR/CAs9 system into clinical applications.
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PMC11678130
To date, previous studies have proposed a combinatorial treatment involving QUE and 5-FU in cancer therapy, with QUE being found to reverse 5-FU resistance and enhance its efficacy in many neoplasms, such as colorectal, breast, and esophageal tumors .
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PMC11740207
Their size significantly influences their differentiation potential, with smaller bodies favoring endodermal differentiation and larger ones supporting mesodermal development.
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PMC11252033
Equal volumes of RNA were retrotranscribed using iScript kit (Biorad).
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PMC11424574
Inhibiting MTA2 expression significantly reduced cell migration (shMTA2-HOS cells, 85.2% decrease; 88.8% decrease in shMTA2-143B cells) and invasion (shMTA2-HOS cells, 87.5% decrease; shMTA2-143B cells, 80.2% decrease) (Figure 4).
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PMC9398137
Sections from formalin-fixed, paraffin-embedded blocks from murine lymphoma xenografts were cut and stained with hematoxylin and eosin.
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PMC9780037
Additional nanoparticle-based systems are nanogels sensitive to the reductive chemical environment in the cytoplasm of cancer cells .
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PMC5311252
Clonal clusters were generated using cBot (Illumina) and sequencing was performed on HiSeq2500 (Illumina) with a read length of 2 × 125 bases, generating an average number of reads per sample of 20.7 million read pairs per sample (ranging from 16.8 to 28 million read pairs).
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PMC11764090
The expression of LeCBF1 is regulated by exogenous ethylene and 1-methylcyclopropene and is not expressed without cold induction in postharvest S. lycopersicum .
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PMC11462673
E Histogram shows the bioluminescence signal values of liver, and spleen.
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PMC9429973
For each age group AML-LTS had significantly lower eGFR in comparison to DEGS1.
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PMC9424261
G The interaction of GSS and MDM2 in tumors were detected by co-IP experiments.
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PMC11534035
Twenty-four hours after seeding, the inserts were removed and the cells were treated with G1, G36, ethanol, or culture medium and photographed at 0, 10, and 20h.
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PMC11767725
According to a recent meta-analysis, MetS has been strongly associated with specific skin diseases, including HS (OR: 4.46), LP (OR: 3.79), and SD (OR: 2.45).
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PMC6642070
6Dichloroacetate antagonizes statin-induced lactate accumulation and improves mice exercise capacity. (
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PMC10545062
Further studies are planned to compare PACC-MAN and SCC+ to manual, provider-driven critical care based on current best clinical practice.
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PMC11585994
Importantly, these nanoparticles demonstrated effective delivery of siBCL11B to both T-ALL cell lines and primary T-ALL cells.
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PMC11574029
Data are presented as the mean ± SEM of three independent experiments, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.
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PMC11676674
The antigenotoxic effect observed in C. monspeliensis extract at the lowest concentration might be due to the presence of punicalagin compounds, being the most abundant molecules identified in the C. monspeliensis leaf extract.
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PMC11360263
The CTO cells exhibited dedifferentiation, stemness, and a hybrid EMT-MET phenotype, ultimately resulting in the generation of PGCCs and the formation of spheroids.
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PMC11155445
From the study, it was found that all the oxorhenium complexes show oxidation properties.
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PMC11046454
However, further efforts are needed to improve the in vivo biostability of aptamers for clinical applications.
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PMC11705484
, CMP9 (10 mg/kg, for 10 days, i.p.
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PMC10530622
This was accompanied by an increase in oxalate formation from hydroxyproline metabolism.
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PMC8345486
Significant differences were found across cell lines for the effects of compounds 22, 23, and 24; the IC50 values of these compounds increased slightly with increasing cell resistance to cisplatin (p < 0.05; post-hoc Bonferroni comparisons, Figure 2A).
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PMC10093184
Loss of p53 function or altered functionality through the mutation in the p53 gene is a common feature in cancer cells and has been described in canine osteosarcoma as well .
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PMC9429973
Nearly 3/4 of the 30 cases, the T1/2 results fluctuated among three periods (9h~24h, 24h~48h, 9h~48h) in one case, suggesting a standardized test procedures such as specimen collection, sample transportation and detection ect needs to set up to ensure the stability and reliability of test results.
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PMC9118379
The following search parameters were used in the three search engines: a precursor mass tolerance of ±10 ppm, a fragment mass tolerance of ±0.01 Da, carbamidomethylation of cysteine as a fixed modification, and oxidation of methionine and acetylation of protein N-term as variable modifications.
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PMC11474209
This biochemical interaction may occur at the cellular level, potentially affecting cell survival, tissue damage, and tumor growth .
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PMC9429973
Systems biology approaches, using computational models, have provided insight into the roles and regulation of specific NFκB components.
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PMC11738017
∗∗∗P ≤ .001; ∗∗∗∗P ≤ .0001.
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PMC11045125
The RNA-seq results obtained from the ΔEBNA2 virus plus Myc tumor 8 were removed from the analysis since this tumor expressed LMP1 (Fig 5A).
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PMC9509578
Downregulation of apoptotic pathways is often observed in cancer cells.
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PMC11144200
Representative images of ELISPOT plate readout analyzing the frequency of IFN-γ-secreted CD8 T cells are shown histograms represent data of the triplicates for 3 × 10 cells from three independent ELISPOT assays, and shown as bars of means + SD. ****
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PMC10914904
This defense system depends on the ability of the immune system to differentiate between self- and nonself-nucleic acids .
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PMC11216402
Distal peaks were defined as 300-bp bins centered on the top 10,000 MACS2 peaks, after removing promoters (<2 kb of a TSS), and peaks open in >30% of ENCODE DNase-seq samples (mostly CTCF sites).
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PMC11792740
Combination therapies, integrating CAR-T, tumor vaccines, and immune checkpoint inhibitors, will become a cornerstone in treating cancer, addressing immune suppression and exhaustion through synergistic effects.
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PMC7582629
In the clinical assessment of a leukemic patient, first step is the analysis and classification of leukemia cells; the second step is to monitor the cells after a specific chemotherapy treatment.
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PMC8193813
The sensor and the LI-820 showed good agreement, as the measurements showed an R of 0.99 and a slope of 1.01.
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PMC11467800
Unlike K562 cells, K562‐IR cells have spindle‐like morphology, are semi‐adherent and capable of forming tumour spheroids in three‐dimensional cell cultures.
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PMC8873393
This approach allowed us to separate the synthesis of nascent transcripts from the accumulation of mature RNAs.
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PMC5173112
In the present study, we investigate the effects of USP21 on proliferation, invasion and cancer stem cells (CSCs) property of RCC cell lines.
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PMC11543885
Clustering.i.
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PMC11806818
A nanozyme-based aptasensor combines the unique properties of nanozymes with the specificity of aptamers for the detection of various biomolecules.
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PMC11799620
Extraction conditions were manipulated using the surface methodology tool.
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PMC11683240
Such early treatment is rare due to delayed diagnoses (5).
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PMC6627640
The finding that repression of PRC1/2 signaling induces cisplatin resistance in TGCTs was unexpected.
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PMC11470381
Further examination revealed that Piezo1-driven calcium response activates downstream calpain-dependent polymerization of the actin cytoskeleton, resulting in the formation of stable immunological synapses .
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PMC9412887
However, the oxygen consumption of SDT increases the hypoxia degree of the tumor tissue, which in turn impedes the efficiency of SDT .
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PMC9429973
60% were male.
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PMC10165258
Scale bar represents 100 μm.
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PMC8409415
The WB results revealed positive NF‐κB‐p65 and negative c‐Jun expressions in A2780 cells (Figure 3A).
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PMC9100622
Cells were analyzed by flow cytometry using an LSR FORTESSA analyzer (BD Biosciences, Franklin Lakes, NJ, USA).
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PMC11519583
Wnt11-Ror2 signaling promotes MP proliferation and adipogenic differentiation and inhibits cellular senescence by regulating stress fiber-induced nuclear blebbing, associated with cGas-STING pathway activation.
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PMC11206502
A decreased percentage of BC cell growth at higher HB concentrations can be explained by the intricate interplay between extracellular nucleotides affecting the cell cycle and autophagy modulation in response to cell density, ultimately influencing cell proliferation rates , as the results of this work have suggested that HB induces autophagy in bladder carcinoma (BC) cells.
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PMC9429973
Methods: EQ-5D-5L, EORTC QLQ-C30 and EORTC QLQ-MY20 questionnaires were administered to all patients in the CARTITUDE-1 Phase 2 and LocoMMotion studies at baseline, day 7, day 28 and every 4 weeks up to 52 weeks.
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PMC11502443
Additionally, although receptor recycling is reported to be inhibited, which affects cell surface expression and further signaling (Almind et al., 1998; Fortin et al., 2010; Mohammad et al., 2014; Gabe et al., 2020).
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PMC11758416
Transfer cell solution into sterile 1.5 mL microcentrifuge tubes and remove Dynabeads using a magnetic separation rack.iii.
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PMC11766350
CHO-K1 was chosen as the target cell line as it has been reported to be more susceptible to transduction by rAAV5, however low levels of DR5 expression mean it would potentially not be as susceptible to TRAIL signaling .
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PMC11323699
While CD47 did not correlate with CD4 and CD8 expression at baseline (Fig. 3b, top right panel), a correlation with CD8 (r = 0.59, p = 0.02) and a trend with CD4 (r = 0.49, p = 0.05) emerged after NACT (Fig. 3b, bottom right panel).
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PMC11592008
The differential expression of NLRP1 in PKs and HaSKpw cells compared with HaCaT and SVTERT cells might be based on the different p53 statuses; NLRP1 is regulated in a p53-dependent manner .
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PMC5261804
Interestingly, the most significant correlation (p = 4.63E-07) was that of the BRAF-KRAS interaction to PLX4720, a compound that targets BRAF.
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PMC11794847
This analysis revealed a detailed cellular landscape of lung adenocarcinoma progression, including various cell types in the tumor environment.
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PMC11583010
Analyses were performed on deglycosylated ADCs with PNGase F deglycosidase.
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PMC11612315
One-way ANOVA followed by Dunnett’s multiple comparison test (p < 0.01, compared with the vehicle + CAP group).
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PMC9429973
The OS for patients who had ever achieved NR, PR, and≥VGPR were 2.4, 24.9, and 62.1 months, respectively (P＜0.001).
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PMC11686380
Statistical analysis was performed using one-way ANOVA. (
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PMC9429973
In order to assess the gene expression profiles of BM EPCs, RNA sequencing and gene set enrichment analysis were performed.
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PMC11422497
Kaplan-Meier curves and log-rank tests were utilized to compare the survival of patients with high and low circ_SMA4 expression.
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PMC9429973
Methods: In order to target translation, we used the FL3 molecule, a synthetic flavagline, which is a known inhibitor of translation initiation in other types of cancers (Boussemart et al., 2014, Nature).
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PMC11532793
Divided counts zti are computed from the catchSalmon or catchKallisto output and then enter the edgeR pipelines as regular read counts.
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PMC11731614
GO Terms Bonferroni adjusted p-value ≤ 0.01.
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PMC11773391
Further experiments found that the application of U0126, an inhibitor of the ERK pathway, reduced the stimulatory effect of TMZ on the transcriptional activity of the MGMT promoter (Figure 1C).
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PMC11585994
Molt4 and T-ALL cells were seeded at a density of 1×10^6 cells per well in a 12-well plate and treated with various intervention combinations for 20 hours.
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PMC9473868
Activated RA-FLSs not only migrate and invade adjacent unaffected joints but also migrate to the sublayer of synovial lining, promoting angiogenesis, and exacerbating synovial hyperplasia and bone destruction .
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PMC7642379
Blue dots represent adherent cells whereas grey dots represent suspension cell lines. (
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PMC6461034
In the last decade, multiple kinase‐targeted drugs, including small‐molecule inhibitors and antibodies, have been approved for clinical use in cancer treatment (Knight et al, 2010).
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PMC11286266
Approximately 2.1 × 10 CHO-K1 Cas9 stable cells carrying the dual UPR reporter ATF6α/IRE1 (XC45-6S cells) were infected at an MOI of 0.3 to favour infection with a single viral particle per cell.
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PMC11544771
Since caspase 8 activation is linked to activation of the extrinsic pathway , we further examined whether CPX/PRE treatments affect the expression of the ligands/death receptors as well as adaptor proteins.
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PMC11502327
Surprisingly, in recent years, researchers have modified nanomaterials onto biomolecules with the aid of aptamer conjugating technology, which has greatly improved the selective targeting ability of materials, providing new opportunities for tumor-targeted therapy.
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PMC9351137
B Histograms showing the quantitative analysis of mislocalizations of cytokinesis regulators at the midbody in mocks and BAF53a or Tip60 depleted cells.
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PMC11788920
The statistical analyses of these data are reported in Supplementary Tables S2, S3, and S8.
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PMC9429973
A drug library comprised of 1,971 FDA approved compounds and 755 clinical compounds will be screened for anti-leukemia efficacy at 3 concentrations, in 3 AML cell lines at 3 timepoints.
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PMC9429973
HMX3 is essential for neuronal development and not expressed in any healthy blood cell type.
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PMC11321678
NTR genes have subgroup‐specific chromatin accessibility patterns, indicating differential regulation of these genes among subgroups.
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PMC6742971
Standard methods to determine the functionality avidity (hereafter abbreviated with “avidity”) are cytotoxicity or IFN-γ Elispot assays with titrated concentrations of antigenic peptide.
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PMC8956657
Error bars represent mean values ± SEM.
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PMC9429973
Minimal residual disease (MRD) was assessed via multiparameter flow cytometry (MFC) with a sensitivity of 10.
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PMC9268183
Based on our research, the most common species reported with analgesic activity (i.e., pain relief) are Cannabis sativa and Papaver somniferum, whilst Plantago sempervirens and Santolina chamaecyparissus were used for mouth infections derived from therapies against cancer.
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PMC11472569
These nanovesicles, once regarded as “cellular waste products”, are now recognized as key regulators of various biological functions and intercellular communication.
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PMC11463018
for 1 h. 12 (0.89 g, 2.93 mmol) was then added and the mixture was refluxed for 3 h. Then, the mixture was allowed to cool and filtered to collect the precipitated solid.
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PMC11721587
Our in vitro kinase assays showed that Fu could phosphorylate S482, which primed CK1 to phosphorylate S485 and T486 (fig. S1, B and C).
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PMC11496491
After RNA was extracted from tissue cells, reverse transcription studies were performed using the PrimeScript™ RT reagent Kit (Japan).
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PMC6901583
The conditioned media from cells expressing vector, BRD4, shBRD4, or shNC were individually incubated with endothelial cells.
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PMC9341513
A full epigenetic and three-dimensional (3D) structural characterization of genome rearrangements is crucial for our understanding of proto-oncogene activation.
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PMC9429973
Aims: We performed a prospective, multicenter, open-label, randomized controlled trial (NCT02623309) comparing Haplo versus UD search strategies for allo HSCT in pts with hematological malignancies older than 55 years after the absence of MSD was established.
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