OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC9275501	However, many studies had carried out to investigate on the drug release of NDCDS in model microenvironment with pH buffer of normal body fluid, or tumor tissue and cell, which is difficult to show the real extent of drug release in vivo.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9352806	Lipidomic analysis revealed that BMS altered the lipid composition of the whole-organism, especially represented by the increased PE, which performed an important role in autophagy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9712534	Statistical values are as follows; **: statistically significant; p = 0.0457.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Statistical", "values", "are", "as", "follows", ";", "*", ...
PMC11345828	H NMR (400 MHz, CDCl3) δ 7.75 (d, J = 8.8 Hz, 0.7H), 7.74 (d, J = 8.4 Hz, 0.3H), 7.54 (s, 0.3H), 7.53 (s, 0.7H), 7.34–7.30 (m, 1H), 7.00–6.92 (m, 1H), 6.61 (s, 1.4H), 6.59 (0.6H), 4.45 (dd, J = 12.4, 4.0 Hz, 1H), 4.28–4.14 (m, 7H), 4.01–3.94 (m, 10H), 3.62–3.55 (m, 1H), 3.42–3.30 (m, 2H), 2.30 (s, 6H), 2.29–2.72 (m, 2H), 2.20–2.10 (m, 5H), 1.31 (d, J = 6.4 Hz, 1.7H), 1.25 (d, J = 3.2 Hz, 0.4H), 1.21 (d, J = 6.4 Hz, 0.6H), 1.14 (d, J = 6.4 Hz, 0.3H), mixture of rotamers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11806182	In both survival curves, the green line represents high expression and the red line represents low expression The top five significantly altered cell subtypes were epithelial.cells.4, epithelial.cells.2, fibroblasts.8, CD8.T.cells.3, and dendritic.cells.5 (Fig. 7B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Twenty-five (51%) patients had neutropenia at HBO initiation, only 5 patients recovered counts at the end of HBO.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Twenty-five", ...
PMC11684821	The most dominant bias is a conserved 10 amino acid motif that arises through use of the TRAJ42 gene to produce usually long CDR3-α loops of 16 or 17 amino acids in length.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10470467	.	[ { "tags": [ "O" ], "tokens": [ "." ] } ]
PMC11786704	Shengwu Zheng: Investigation, Conceptualization.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Shengwu", "Zheng", ":", "Investigation", ",", "Conceptualization", "." ] } ]
PMC11633763	Glucose (10 mM), the oxidative phosphorylation inhibitor oligomycin (1.0 μM) and the glycolytic inhibitor 2‐deoxyglucose (2‐DG, 50 mM) were sequentially injected into each well at the indicated time points.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9341513	It would be interesting to see if in the future, such simulations could also help us understand the mechanisms behind the epigenomic rearrangement.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC6160470	They can be either independent or in exclusive interaction.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "They", "can", "be", "either", "independent", "or", "in", "exclusive", "interaction", "." ] } ]
PMC8839885	In addition, we monitored changes in levels of phospho-ERK1/2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ",", "we", "monitored", "changes", "in", "levels", "of", "phospho-ERK1/2", ...
PMC11363012	Both targeted and untargeted MS suggest that a majority of monoterpene indole alkaloids accumulate in specialized cells that represent only a small fraction of the total cell population.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The data on the risk of myeloid leukemia among patients with IBD are limited and there has been only a couple of studies that evaluated the incidence of myeloid leukemia in this patient population.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9812014	However, before these alkaloids and their derivatives can be used as antivirals, a better understanding of their pharmacological properties and clinical outcomes is required.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC6379402	Then, we compute , the average of the association matrices over ten different runs, and measure the stability of these clusterings according to the following dispersion coefficients:10[12pt] $$ _k = }( }( )} )}}}} - ( }}} )^2}},$$ηk=varoffdiagC¯n∕k-1n-1-n∕k-1n-12,11[12pt] $$ _k = _ \,( ) - 1/k} )^2}} )( )}},$$νk=∑i≠jC¯i,j-1∕k2nn-11∕k-1∕k2, where n is the number of genes and offdiag () is the vector containing off-diagonal entries of .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11703896	The ability of rapamycin to bind to other receptors in the cancer cells and other abnormal cells have not been discovered.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "ability", ...
PMC11297139	b A barplot illustrating the number of linkages between upregulated DEGs and upregulated, downregulated, and control cREs, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "b", "A", "barplot...
PMC10654497	Characteristic heatmaps of risk score distribution, prognostic status, and three prognostic genes for each patient in TCGA database.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Characteristic", "heatmaps", ...
PMC5941560	Then, if present, BreakDancer calls that overlapped this merged set were removed, and the non-overlapping BreakDancer calls were merged into the GATK/Pindel set.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973	Summary/Conclusion: Nemtabrutinib has promising antitumor activity with a manageable safety profile in pts with CLL/SLL exposed to multiple lines of therapy, including in those who had progression of disease on prior covalent BTKi.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11348300	Tissue function assessment is utilized in a range of interventional procedures so that improved decisions can be made about tissue removal or repair.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Tissue"...
PMC11730320	She also tolerated well live attenuated vaccines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "She", "also", "tolerated", "well", "live", "attenuated", "vaccines", "." ] } ]
PMC8873393	Blue stippled lines demarcate thresholds of lowly transcribing cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Blue", "stippled", "lines", "demarcate", "thresholds", "of", "lowly", "transcribing", "cells", "." ] ...
PMC11543885	Poly-L-lysine (PLL) coating of the plates.a.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Poly-L-lysine", "(", "PLL", ")", "coating", "of", "the", "plates.a", "." ] } ]
PMC11618052	H NMR (400 MHz, δ ppm DMSO-d6): 8.63 (s, 1H, triazole CH), 8.08 (d, J = 7.6 Hz, 1H, Ar–H), 7.84 (t, J = 7.2 Hz, 1H, Ar–H), 7.76 (d, J = 8.0 Hz, 1H, Ar–H), 7.73 (d, J = 8.6 Hz, 2H, Ar–H p-O–CH3 C6H4), 7.63–7.40 (m, 6H, Ar–H), 7.10 (d, J = 8.6 Hz, 2H, Ar–H p-O–CH3 C6H4), 4.52 (s, 2H, S–CH2), 3.80 (s, 3H, O–CH3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9545714	In the present study, correlation was found between reduction of TEWL and various attributes in skin's appearance that were captured by VISIA photography and qualitatively and quantitatively analyzed (see Supporting information file attached to this manuscript).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Moreover, As2O3 could also significantly elevate the expression of NLRP3, caspase-1 proteins and ICD related proteins, leading to increase the expression of apoptosis related proteins Bax, Caspas-3, PARP.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11637820	Staphylococcus aureus, Enterococcus faecalis, Corynebacterium spp.,	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Staphylococcus", "aureus", ",", "Enterococcus", "faecalis", ",", "Corynebacterium", "spp", ".", "," ] ...
PMC10926885	ceRNA network upstream of NDE1. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ceRNA", "network", "upstream", "of", "NDE1", ".", "(" ] } ]
PMC9429973	Results: T22-PE24-H6 nanoparticle demonstrated a potent in vitro anticancer effect in MONO-MAC-6 cell line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "Results", ":", "T22-PE24-H6", "nanoparticle", "demonstrated", ...
PMC6892818	CD40 is expressed by human RCC lines in vitro and its stimulation by soluble agonist triggered secretion of pro-inflammatory cytokines, yet no direct pro-apoptotic effects have been reported.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7553912	Some cytokines were recently reported to involve attachment of crystals or aggregates to renal epithelial cells, and crystal retention.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Some", "cytokines", "were", ...
PMC9784246	It has been evaluated for its cytotoxic activities against MCF-7, NCI-H460, HeLa, and hepatocellular carcinoma (HepG2) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ ...
PMC11612794	Right: Electrostatic potential of Mis12C mapped on the surface representation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Right", ":", "Electrostatic", "potential", "of", "Mis12C", "mapped", "on", "the", "su...
PMC7351993	This image construction is continuously repeated for multiple events.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "image", "construction", "is", "continuously", "repeated", "for", "multiple", "events", "." ] ...
PMC11218145	Mice received administrations of solvent or 4 mg/kg of TB twice a week.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mice", "received", "administrations", "of", "solvent", "or", "4", "mg/kg", ...
PMC11757230	Mechanisms by which MSCs promote metastasis of solid tumors include transition of MSCs to tumor-associated fibroblasts and promotion of epithelial-mesenchymal transition of tumor cells via transforming growth factor-β (TGF-β) , degradation and remodeling of extracellular matrix via matrix metalloproteinase , and signaling to tumor cells via secreted factors such as chemokine receptor (CCR) 5 ligand and IL-17B .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	2017;129(24):3227–3236).	[ { "tags": [ "O", "O", "O" ], "tokens": [ "2017;129(24):3227–3236", ")", "." ] } ]
PMC11519077	These cells were exposed to IL-1 beta at a concentration of 10 ng/mL for 24 h. In each well, 30,000 cells from three sources of MSCs (AD-MSC, BM-MSC, and MB-MSC) were separately cocultured with IL-1 beta–treated Caco-2 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Aims: We decided to study if the aberrant accumulation of FLT3-ITD affects the functioning of the ER.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Aims", ":", "We", "decided", "to", ...
PMC11653533	The global distribution of the genus ‘Ficus’ is demonstrated in Fig. 2 (Facility, 2024).Fig.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "global", "distribution", "of", ...
PMC11513571	Culture supernatants were collected and measured by ELISA for full spike protein-specific IgG antibodies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Culture", "supernatants", "were", "collected", "and", "measured", "by"...
PMC11155445	Bis acyl thiourea (104a–f) did not exhibit any antimicrobial activity against both strains E. coli and S. aureus because of steric factors caused by bulky aromatic rings preventing the desired interactions (Fig. 39).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11001582	We detected a significant reduction, by 41% in (GR)400 and 25% in (PR)400, in functional motor unit number in the extensor digitorum longus (EDL) muscles when compared with WT littermates (Fig. 4f,g).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Chromosome-banding analysis was performed using RHG and GTG banding techniques.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Chromosome-banding", "analysis", "was", "performed", "using", "RHG", "and", "GTG", "banding", "t...
PMC11772585	Data are shown as mean ± SEM. *	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "shown", "as", "mean", "±", "SEM", ".", "*" ] } ]
PMC8753818	Results of this study showed that the expression of luciferase in CHO-KO cells was 1.7 times more than parenteral CHO-K1 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "Results", ...
PMC11727145	We have shown that mGreen’s medium was the medium that performed with the best results for maintaining the DED constructs (Figure 2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973	Overall and reactivation free survival were analyzed according to liver involvement.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Overall", "and", "reactivation", "free", "survival", "were", "analyzed", "according", "to",...
PMC11650848	Scaled scores were used to correct for any small differences in age.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scaled", "scores", "were", "used", "to", "correct", "for", "any", "small", ...
PMC9693627	The fragment was cloned into pET30a vector (Novagen), and verified by Sanger sequencing.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "fragment", "was", "cloned", "into", "pET30a", ...
PMC11243198	Utilizing JChem for chemical structure searches, we identified fifty-two analogs similar to both GANT61 and its active form, GANT61-D. The screening of these fifty-two analogs in high-throughput Hh functional cell-based assays identified six potential inhibitors with potencies in the low micromolar range.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4443654	To test for the enrichment or depletion of a chromatin feature over a given boundary, a two-tailed Mann–Whitney test was used to compare the boundary bin with the ten outermost bins of the window (five from either side).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Self-limited skin rash was seen in 4 (40%) patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Self-limited", "skin", "rash", "was", "seen", "in", "4", "(", "40", "%", ...
PMC11489351	F, measurement of intracellular lactate in cells treated as in (A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "F", ",", "measurement", "of", "intracellular", "lactate", "in", ...
PMC11572213	The TET2 gene encodes a member of the TET family of enzymes that alter the epigenetic state of DNA by converting 5-mC to 5-hmC. Somatic loss-of-function mutations in TET2 are associated with poor prognosis and advanced disease progression in myelodysplastic syndromes, AML, and chronic myelomonocytic leukemia.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11697703	Regulation of dendritic branching and spines may require different levels of MAPK8, and the optimal repression needed for appropriate spine regulation may require both miR-193b and miR-365.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5811757	MDR in cancer is generally the result of increased expression of membrane efflux proteins which belong to the ATP-binding cassette (ABC) transporters superfamily.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11789597	In this work, we comprehensively demonstrated the diverse roles of CAV1 in modulating MM cell adhesion, natural killer (NK) cell‐mediated cytotoxicity, glutaminolysis, and reactive oxygen species (ROS) homeostasis and validated CAV1 as a potent target for enhancing the efficacy of bortezomib‐ and NK cell‐based anti‐MM therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11188874	We hypothesized that proteasome activation could concomitantly increase antigen abundance and diversity in multiple myeloma cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "hypothesized", "that", "proteasome", "activation", ...
PMC10196713	In brief, OVK18 cells were exposed to cisplatin at a final concentration of 0.1 µM as the initial concentration.	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "brief", ",", ...
PMC9918897	The antitumor activity of xanthohumol (XN) from hops (Humulus lupulus (Cannabinaceae)) has been demonstrated in previous studies, both in vitro and in vivo .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	AdCAR-T cell stimulation leads to T cell dysfunction (Fig 1) in in vitro long-term efficacy studies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "AdCAR-T", "cell", "stimulation", "leads", ...
PMC11754094	Nine sizes of DNA fragments were mixed and sequenced with Illumina under various PCR cycle conditions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Nine", "sizes", "of", "DNA", "fragments", "were", ...
PMC9646302	We focused on the function of LAPTM5 as a marker of ccRCC, and the results demonstrate that LAPTM5 regulates JNK and p38 phosphorylation by directly interacting with RAC1 to promote proliferation, migration, and invasion of ccRCC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11740207	These profiles facilitate the identification of therapeutic agents that specifically target the stem-like population within AML, thereby addressing the root of disease persistence and relapse.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11670407	P < 0.05, **P < 0.01 vs. the corresponding controlFig.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "P", "<", "0.05", ",", "", "", "P", "<", "0.01", "vs.", ...
PMC9429973	Finally, since miR-181a and miR-181b are involved in cell death, we assessed whether those miRNAs participate in CLL cells death induced by Ibrutinib: we found that the silencing of both miRNAs improves CLL cell survival during Ibrutinib treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	T-ALLs that later progressed to type-2 relapses exhibited a complex subclonal architecture, unexpectedly, already at the time of initial diagnosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "T-ALLs", "th...
PMC9848491	Expression of immune checkpoint genes in high-risk and low-risk populations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Expression", "of", "immune", "checkpoint", "genes", "in", "high-risk", "and", "low-risk", "popul...
PMC11225860	For this, cells were treated for 5 days, washed, and cultured an additional four days without drug.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "this", ",", "ce...
PMC10419319	The analysis identified several key pathways, including the VEGF, MAPK, and AKT pathways, which have been implicated in cancer progression and drug resistance .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10033453	Therefore, it is important to characterize patient-specific levels of IFN pathway defects within a tumor prior to administering vesiculovirus-based oncolytics.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefore", ",", ...
PMC10654497	In addition, it is crucial to develop a more accurate prognostic model.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ",", "it", "is", "crucial", "to", "develop", "a", ...
PMC11680049	The investment in the biosynthesis of substances with high antioxidant and protective properties, which polyphenols undoubtedly possess, underlies the high potential for improving the resistance of individual leaves to water stress as the height of the plant increases.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The gastrointestinal system is one of the areas most strongly affected by aGVHD.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "gastrointestinal", "system", "is", "one", "of", "the", "areas", ...
PMC11594074	A concentration-dependent decrease in cell migration and wound healing was observed in both cell lines with increasing doses of compound 4 (Figure 8).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	Image: Summary/Conclusion: We have identified three molecular clusters in IgM monoclonal gammopathies with distinct clinical, proteomic, metabolomic and immune features, suggesting a potential biologic classification that may have therapeutic implications.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9388315	P < 0.05 was considered statistically significant.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "P", "<", "0.05", "was", "considered", "statistically", "significant", "." ] } ]
PMC11766350	A shRNA-based approach was used to inhibit TRAIL expression, which improved rAAV-TRAIL yields.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "shRNA-based", "approach", "was", "used", "to", "inhibit", "...
PMC11300639	Specific shRNA and shControl were used to transfect cells for 72 h, and puromycin was used to screen shRNA positive cells for 48 h. The cells were digested with trypsin and centrifuged by 1050 RPM for 5 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7887261	Recent studies suggest that rare variants exhibit stronger effect sizes and might play a crucial role in the etiology of lung cancers (LC).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC5034105	As of 14 July 2016, more than 60 countries/territories have reported continuing mosquito-borne transmission of ZIKV.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "of", "14", "July", "2016", ",", ...
PMC6163708	The Hedgehog (HH) signaling pathway is a morphogenesis pathway crucial for the growth and patterning of various tissues during embryonic development .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC9368503	Plates were spun at 1000× g and grown at 37 °C with 5% CO2 for 3 days before imaging.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Plates", "we...
PMC11656657	Schematic representation of PBMC co-cultured with OS tumor cells (A) or with OS conditioned medium (CM) for 72 h (B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Methods: BRUIN is a phase 1/2 global, multicenter study (NCT03740529) of pirtobrutinib in pts with advanced B-cell malignancies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":...
PMC9429973	Monosomy 7 was observed in 2/18 patients (>70% of metaphases), +8 in 2/18 patients (5-6.6% of metaphases), inv(17)(p11.2q21) in 1/18 patients (18.75% of metaphases), complex karyotypes in 2/18 patients (31.3-73.2% of metaphases including abnormalities of 1q, 2q, 4q, 5q, 16q, 18 and Xp), in one patient after SCT in the transformation of MDS into s-AML and in the other at diagnosis with t-MDS) and chromatid and chromosome breaks in 1/18 patients, (8,6-9,6% of metaphases) in 2 different BM samples taken with an interval of 3 months, which were also found in his brother’s BM karyotype.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11522251	In light of the aforementioned research, we postulated that HOXB8 could be a crucial component of the cetuximab resistance mechanism.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "light", "of...
PMC11547972	It, however, enhanced the following proteins: cdk1 (A498, KTCTL-26), pcdk1 (all cell lines), pcdk2 (KTCTL-26), Cyclin A (A498), Cyclin B (KTCTL-26), p19 (all cell lines), p27 (A498), Bax (all cell lines).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC11656380	The strategy of the direct inhibition of NOTCH1 signaling in T-ALL cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "strategy", "of", "the", "direct", "inhibition", "of", "NOTCH1", "signalin...
PMC9275501	The study showed that the proportion range of the initial designed optimal concentration of CUR and Sun was maintained at the tumor target site (Sun:CUR = 0.5–0.25), resulting in the optimal synergistic effect and more effective treatment results.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11509278	The background ions were removed from the blank samples.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "background", "ions", "were", "removed", "from", "the", "blank", "samples", "." ] } ]
PMC11518702	Models outlining prospective roles for C1ORF150 within FcϵR1, KIT, and hEPOR/JAK2 membrane–proximal signaling complexes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Models", "outlining", "prospective", "roles"...
PMC11786704	Male C57BL/6 mice were purchased from Shanghai SLAC Laboratory Animal Co., Ltd (SLAC).	[ { "tags": [ "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Male", "C57BL/6", "mice", "were", "purchased", ...
PMC11763111	After 24 h of antigen stimulation, the 4KO-LLT1 group showed a higher mean fluorescence intensity (MFI) of CD62L compared to the 4KO group (Fig. 2G).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11745823	The cells in different treatment groups were appropriately diluted, and about 500 cells were inoculated into each well to ensure that single cells could form independent clones.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9841531	Multitarget agents with these polypharmacological profiles have been of increasing interest within recent years, and the herein discovered compounds 22–23 build a good starting point for the development of novel multitarget agents stretching from ABC to SLC transporters.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9275501

However, many studies had carried out to investigate on the drug release of NDCDS in model microenvironment with pH buffer of normal body fluid, or tumor tissue and cell, which is difficult to show the real extent of drug release in vivo.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9352806

Lipidomic analysis revealed that BMS altered the lipid composition of the whole-organism, especially represented by the increased PE, which performed an important role in autophagy.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9712534

Statistical values are as follows; **: statistically significant; p = 0.0457.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Statistical", "values", "are", "as", "follows", ";", "*", ...

PMC11345828

H NMR (400 MHz, CDCl3) δ 7.75 (d, J = 8.8 Hz, 0.7H), 7.74 (d, J = 8.4 Hz, 0.3H), 7.54 (s, 0.3H), 7.53 (s, 0.7H), 7.34–7.30 (m, 1H), 7.00–6.92 (m, 1H), 6.61 (s, 1.4H), 6.59 (0.6H), 4.45 (dd, J = 12.4, 4.0 Hz, 1H), 4.28–4.14 (m, 7H), 4.01–3.94 (m, 10H), 3.62–3.55 (m, 1H), 3.42–3.30 (m, 2H), 2.30 (s, 6H), 2.29–2.72 (m, 2H), 2.20–2.10 (m, 5H), 1.31 (d, J = 6.4 Hz, 1.7H), 1.25 (d, J = 3.2 Hz, 0.4H), 1.21 (d, J = 6.4 Hz, 0.6H), 1.14 (d, J = 6.4 Hz, 0.3H), mixture of rotamers.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11806182

In both survival curves, the green line represents high expression and the red line represents low expression The top five significantly altered cell subtypes were epithelial.cells.4, epithelial.cells.2, fibroblasts.8, CD8.T.cells.3, and dendritic.cells.5 (Fig. 7B).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Twenty-five (51%) patients had neutropenia at HBO initiation, only 5 patients recovered counts at the end of HBO.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Twenty-five", ...

PMC11684821

The most dominant bias is a conserved 10 amino acid motif that arises through use of the TRAJ42 gene to produce usually long CDR3-α loops of 16 or 17 amino acids in length.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10470467

.

[ { "tags": [ "O" ], "tokens": [ "." ] } ]

PMC11786704

Shengwu Zheng: Investigation, Conceptualization.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Shengwu", "Zheng", ":", "Investigation", ",", "Conceptualization", "." ] } ]

PMC11633763

Glucose (10 mM), the oxidative phosphorylation inhibitor oligomycin (1.0 μM) and the glycolytic inhibitor 2‐deoxyglucose (2‐DG, 50 mM) were sequentially injected into each well at the indicated time points.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9341513

It would be interesting to see if in the future, such simulations could also help us understand the mechanisms behind the epigenomic rearrangement.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC6160470

They can be either independent or in exclusive interaction.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "They", "can", "be", "either", "independent", "or", "in", "exclusive", "interaction", "." ] } ]

PMC8839885

In addition, we monitored changes in levels of phospho-ERK1/2.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ",", "we", "monitored", "changes", "in", "levels", "of", "phospho-ERK1/2", ...

PMC11363012

Both targeted and untargeted MS suggest that a majority of monoterpene indole alkaloids accumulate in specialized cells that represent only a small fraction of the total cell population.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

The data on the risk of myeloid leukemia among patients with IBD are limited and there has been only a couple of studies that evaluated the incidence of myeloid leukemia in this patient population.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9812014

However, before these alkaloids and their derivatives can be used as antivirals, a better understanding of their pharmacological properties and clinical outcomes is required.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC6379402

Then, we compute , the average of the association matrices over ten different runs, and measure the stability of these clusterings according to the following dispersion coefficients:10[12pt] $$ _k = }( }( )} )}}}} - ( }}} )^2}},$$ηk=varoffdiagC¯n∕k-1n-1-n∕k-1n-12,11[12pt] $$ _k = _ \,( ) - 1/k} )^2}} )( )}},$$νk=∑i≠jC¯i,j-1∕k2nn-11∕k-1∕k2, where n is the number of genes and offdiag () is the vector containing off-diagonal entries of .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11703896

The ability of rapamycin to bind to other receptors in the cancer cells and other abnormal cells have not been discovered.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "ability", ...

PMC11297139

b A barplot illustrating the number of linkages between upregulated DEGs and upregulated, downregulated, and control cREs, respectively.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "b", "A", "barplot...

PMC10654497

Characteristic heatmaps of risk score distribution, prognostic status, and three prognostic genes for each patient in TCGA database.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Characteristic", "heatmaps", ...

PMC5941560

Then, if present, BreakDancer calls that overlapped this merged set were removed, and the non-overlapping BreakDancer calls were merged into the GATK/Pindel set.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC9429973

Summary/Conclusion: Nemtabrutinib has promising antitumor activity with a manageable safety profile in pts with CLL/SLL exposed to multiple lines of therapy, including in those who had progression of disease on prior covalent BTKi.

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PMC11348300

Tissue function assessment is utilized in a range of interventional procedures so that improved decisions can be made about tissue removal or repair.

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PMC11730320

She also tolerated well live attenuated vaccines.

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PMC8873393

Blue stippled lines demarcate thresholds of lowly transcribing cells.

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PMC11543885

Poly-L-lysine (PLL) coating of the plates.a.

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PMC11618052

H NMR (400 MHz, δ ppm DMSO-d6): 8.63 (s, 1H, triazole CH), 8.08 (d, J = 7.6 Hz, 1H, Ar–H), 7.84 (t, J = 7.2 Hz, 1H, Ar–H), 7.76 (d, J = 8.0 Hz, 1H, Ar–H), 7.73 (d, J = 8.6 Hz, 2H, Ar–H p-O–CH3 C6H4), 7.63–7.40 (m, 6H, Ar–H), 7.10 (d, J = 8.6 Hz, 2H, Ar–H p-O–CH3 C6H4), 4.52 (s, 2H, S–CH2), 3.80 (s, 3H, O–CH3).

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PMC9545714

In the present study, correlation was found between reduction of TEWL and various attributes in skin's appearance that were captured by VISIA photography and qualitatively and quantitatively analyzed (see Supporting information file attached to this manuscript).

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PMC9429973

Moreover, As2O3 could also significantly elevate the expression of NLRP3, caspase-1 proteins and ICD related proteins, leading to increase the expression of apoptosis related proteins Bax, Caspas-3, PARP.

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PMC11637820

Staphylococcus aureus, Enterococcus faecalis, Corynebacterium spp.,

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PMC10926885

ceRNA network upstream of NDE1. (

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PMC9429973

Results: T22-PE24-H6 nanoparticle demonstrated a potent in vitro anticancer effect in MONO-MAC-6 cell line.

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PMC6892818

CD40 is expressed by human RCC lines in vitro and its stimulation by soluble agonist triggered secretion of pro-inflammatory cytokines, yet no direct pro-apoptotic effects have been reported.

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PMC7553912

Some cytokines were recently reported to involve attachment of crystals or aggregates to renal epithelial cells, and crystal retention.

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PMC9784246

It has been evaluated for its cytotoxic activities against MCF-7, NCI-H460, HeLa, and hepatocellular carcinoma (HepG2) .

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PMC11612794

Right: Electrostatic potential of Mis12C mapped on the surface representation.

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PMC7351993

This image construction is continuously repeated for multiple events.

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PMC11218145

Mice received administrations of solvent or 4 mg/kg of TB twice a week.

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PMC11757230

Mechanisms by which MSCs promote metastasis of solid tumors include transition of MSCs to tumor-associated fibroblasts and promotion of epithelial-mesenchymal transition of tumor cells via transforming growth factor-β (TGF-β) , degradation and remodeling of extracellular matrix via matrix metalloproteinase , and signaling to tumor cells via secreted factors such as chemokine receptor (CCR) 5 ligand and IL-17B .

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PMC9429973

2017;129(24):3227–3236).

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PMC11519077

These cells were exposed to IL-1 beta at a concentration of 10 ng/mL for 24 h. In each well, 30,000 cells from three sources of MSCs (AD-MSC, BM-MSC, and MB-MSC) were separately cocultured with IL-1 beta–treated Caco-2 cells.

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PMC9429973

Aims: We decided to study if the aberrant accumulation of FLT3-ITD affects the functioning of the ER.

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PMC11653533

The global distribution of the genus ‘Ficus’ is demonstrated in Fig. 2 (Facility, 2024).Fig.

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PMC11513571

Culture supernatants were collected and measured by ELISA for full spike protein-specific IgG antibodies.

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PMC11155445

Bis acyl thiourea (104a–f) did not exhibit any antimicrobial activity against both strains E. coli and S. aureus because of steric factors caused by bulky aromatic rings preventing the desired interactions (Fig. 39).

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PMC11001582

We detected a significant reduction, by 41% in (GR)400 and 25% in (PR)400, in functional motor unit number in the extensor digitorum longus (EDL) muscles when compared with WT littermates (Fig. 4f,g).

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PMC9429973

Chromosome-banding analysis was performed using RHG and GTG banding techniques.

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PMC11772585

Data are shown as mean ± SEM. *

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PMC8753818

Results of this study showed that the expression of luciferase in CHO-KO cells was 1.7 times more than parenteral CHO-K1 cells.

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PMC11727145

We have shown that mGreen’s medium was the medium that performed with the best results for maintaining the DED constructs (Figure 2).

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PMC9429973

Overall and reactivation free survival were analyzed according to liver involvement.

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PMC11650848

Scaled scores were used to correct for any small differences in age.

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PMC9693627

The fragment was cloned into pET30a vector (Novagen), and verified by Sanger sequencing.

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PMC11243198

Utilizing JChem for chemical structure searches, we identified fifty-two analogs similar to both GANT61 and its active form, GANT61-D. The screening of these fifty-two analogs in high-throughput Hh functional cell-based assays identified six potential inhibitors with potencies in the low micromolar range.

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PMC4443654

To test for the enrichment or depletion of a chromatin feature over a given boundary, a two-tailed Mann–Whitney test was used to compare the boundary bin with the ten outermost bins of the window (five from either side).

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PMC9429973

Self-limited skin rash was seen in 4 (40%) patients.

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PMC11489351

F, measurement of intracellular lactate in cells treated as in (A).

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PMC11572213

The TET2 gene encodes a member of the TET family of enzymes that alter the epigenetic state of DNA by converting 5-mC to 5-hmC. Somatic loss-of-function mutations in TET2 are associated with poor prognosis and advanced disease progression in myelodysplastic syndromes, AML, and chronic myelomonocytic leukemia.

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PMC11697703

Regulation of dendritic branching and spines may require different levels of MAPK8, and the optimal repression needed for appropriate spine regulation may require both miR-193b and miR-365.

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PMC5811757

MDR in cancer is generally the result of increased expression of membrane efflux proteins which belong to the ATP-binding cassette (ABC) transporters superfamily.

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PMC11789597

In this work, we comprehensively demonstrated the diverse roles of CAV1 in modulating MM cell adhesion, natural killer (NK) cell‐mediated cytotoxicity, glutaminolysis, and reactive oxygen species (ROS) homeostasis and validated CAV1 as a potent target for enhancing the efficacy of bortezomib‐ and NK cell‐based anti‐MM therapy.

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PMC11188874

We hypothesized that proteasome activation could concomitantly increase antigen abundance and diversity in multiple myeloma cells.

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PMC10196713

In brief, OVK18 cells were exposed to cisplatin at a final concentration of 0.1 µM as the initial concentration.

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PMC9918897

The antitumor activity of xanthohumol (XN) from hops (Humulus lupulus (Cannabinaceae)) has been demonstrated in previous studies, both in vitro and in vivo .

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PMC9429973

AdCAR-T cell stimulation leads to T cell dysfunction (Fig 1) in in vitro long-term efficacy studies.

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PMC11754094

Nine sizes of DNA fragments were mixed and sequenced with Illumina under various PCR cycle conditions.

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PMC9646302

We focused on the function of LAPTM5 as a marker of ccRCC, and the results demonstrate that LAPTM5 regulates JNK and p38 phosphorylation by directly interacting with RAC1 to promote proliferation, migration, and invasion of ccRCC.

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PMC11740207

These profiles facilitate the identification of therapeutic agents that specifically target the stem-like population within AML, thereby addressing the root of disease persistence and relapse.

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PMC11670407

P < 0.05, **P < 0.01 vs. the corresponding controlFig.

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PMC9429973

Finally, since miR-181a and miR-181b are involved in cell death, we assessed whether those miRNAs participate in CLL cells death induced by Ibrutinib: we found that the silencing of both miRNAs improves CLL cell survival during Ibrutinib treatment.

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PMC9429973

T-ALLs that later progressed to type-2 relapses exhibited a complex subclonal architecture, unexpectedly, already at the time of initial diagnosis.

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PMC9848491

Expression of immune checkpoint genes in high-risk and low-risk populations.

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PMC11225860

For this, cells were treated for 5 days, washed, and cultured an additional four days without drug.

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PMC10419319

The analysis identified several key pathways, including the VEGF, MAPK, and AKT pathways, which have been implicated in cancer progression and drug resistance .

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PMC10033453

Therefore, it is important to characterize patient-specific levels of IFN pathway defects within a tumor prior to administering vesiculovirus-based oncolytics.

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PMC10654497

In addition, it is crucial to develop a more accurate prognostic model.

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PMC11680049

The investment in the biosynthesis of substances with high antioxidant and protective properties, which polyphenols undoubtedly possess, underlies the high potential for improving the resistance of individual leaves to water stress as the height of the plant increases.

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PMC9429973

The gastrointestinal system is one of the areas most strongly affected by aGVHD.

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PMC11594074

A concentration-dependent decrease in cell migration and wound healing was observed in both cell lines with increasing doses of compound 4 (Figure 8).

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PMC9429973

Image: Summary/Conclusion: We have identified three molecular clusters in IgM monoclonal gammopathies with distinct clinical, proteomic, metabolomic and immune features, suggesting a potential biologic classification that may have therapeutic implications.

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PMC9388315

P < 0.05 was considered statistically significant.

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PMC11766350

A shRNA-based approach was used to inhibit TRAIL expression, which improved rAAV-TRAIL yields.

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PMC11300639

Specific shRNA and shControl were used to transfect cells for 72 h, and puromycin was used to screen shRNA positive cells for 48 h. The cells were digested with trypsin and centrifuged by 1050 RPM for 5 min.

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PMC7887261

Recent studies suggest that rare variants exhibit stronger effect sizes and might play a crucial role in the etiology of lung cancers (LC).

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PMC5034105

As of 14 July 2016, more than 60 countries/territories have reported continuing mosquito-borne transmission of ZIKV.

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PMC6163708

The Hedgehog (HH) signaling pathway is a morphogenesis pathway crucial for the growth and patterning of various tissues during embryonic development .

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PMC9368503

Plates were spun at 1000× g and grown at 37 °C with 5% CO2 for 3 days before imaging.

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PMC11656657

Schematic representation of PBMC co-cultured with OS tumor cells (A) or with OS conditioned medium (CM) for 72 h (B).

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PMC9429973

Methods: BRUIN is a phase 1/2 global, multicenter study (NCT03740529) of pirtobrutinib in pts with advanced B-cell malignancies.

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PMC9429973

Monosomy 7 was observed in 2/18 patients (>70% of metaphases), +8 in 2/18 patients (5-6.6% of metaphases), inv(17)(p11.2q21) in 1/18 patients (18.75% of metaphases), complex karyotypes in 2/18 patients (31.3-73.2% of metaphases including abnormalities of 1q, 2q, 4q, 5q, 16q, 18 and Xp), in one patient after SCT in the transformation of MDS into s-AML and in the other at diagnosis with t-MDS) and chromatid and chromosome breaks in 1/18 patients, (8,6-9,6% of metaphases) in 2 different BM samples taken with an interval of 3 months, which were also found in his brother’s BM karyotype.

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PMC11522251

In light of the aforementioned research, we postulated that HOXB8 could be a crucial component of the cetuximab resistance mechanism.

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PMC11547972

It, however, enhanced the following proteins: cdk1 (A498, KTCTL-26), pcdk1 (all cell lines), pcdk2 (KTCTL-26), Cyclin A (A498), Cyclin B (KTCTL-26), p19 (all cell lines), p27 (A498), Bax (all cell lines).

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PMC11656380

The strategy of the direct inhibition of NOTCH1 signaling in T-ALL cells.

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PMC9275501

The study showed that the proportion range of the initial designed optimal concentration of CUR and Sun was maintained at the tumor target site (Sun:CUR = 0.5–0.25), resulting in the optimal synergistic effect and more effective treatment results.

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PMC11509278

The background ions were removed from the blank samples.

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PMC11518702

Models outlining prospective roles for C1ORF150 within FcϵR1, KIT, and hEPOR/JAK2 membrane–proximal signaling complexes.

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PMC11786704

Male C57BL/6 mice were purchased from Shanghai SLAC Laboratory Animal Co., Ltd (SLAC).

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PMC11763111

After 24 h of antigen stimulation, the 4KO-LLT1 group showed a higher mean fluorescence intensity (MFI) of CD62L compared to the 4KO group (Fig. 2G).

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PMC11745823

The cells in different treatment groups were appropriately diluted, and about 500 cells were inoculated into each well to ensure that single cells could form independent clones.

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PMC9841531

Multitarget agents with these polypharmacological profiles have been of increasing interest within recent years, and the herein discovered compounds 22–23 build a good starting point for the development of novel multitarget agents stretching from ABC to SLC transporters.

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