OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC10719213	The present study demonstrates that in T-cell lines and in ex vivo cultured lymphocytes, cladribine did not affect the integrity of the mitochondrial genome and was not mutagenic to mtDNA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10482220	Fig. 5 A clearly established that endogenous G3BP was efficiently coimmunoprecipitated with GFP-G3BP (lane 4), GFP-S149A (lane 6), GFP-S332A (lane 10), and GFP-S232E (lane 12).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11656048	MDA, the final product of lipid peroxidation, is an important end product of lipid ROS (Yin et al., 2022).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11769516	The effect of fumonidins on the ENS depends on the gastrointestinal segment and the type of intestinal plexus .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "effect", "of", "fumonidins", "o...
PMC9583612	As technology—especially CEMS flux algorithms and emission localization capability—improves, it would be possible to provide real-time estimates of site-level methane emissions that can be used in lieu of engineering-based inventory estimates for each site.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11774112	PLA was obtained from Daigang Biological Engineering (Jinan, China).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PLA", "was", "obtained", "from", "Daigang", "Biological", "Engineering", "(", "J...
PMC9878562	Transmigration towards 10 nM CXCL12 was performed and calculated as described in Figure 1 . (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Transmigration", "towards", "10", "nM", "CXCL12", "was", "p...
PMC9429973	This might eventually allow for biology-informed treatment development for pts in this high-risk disease setting.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "might", "eventually", "allow", "for", "biology-informed",...
PMC5311252	ZBTB7A has been shown to be a TS in prostate cancer as ZBTB7A activity results in increased RB1 stability.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ZBTB7A", "has", "been", "shown", ...
PMC11754432	To investigate the role of ALOX15B in psoriasis, keratinocytes in vitro were treated with a cocktail of IL-17A, interferon (IFN)γ and tumour necrosis factor (TNF)α to induce a psoriasis-like phenotype following 72 h of transfection with control or ALOX15B siRNA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Ruxolitinib was more frequently used in patients who underwent to hospital than managed at home. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Ruxolitinib", "was", "more", "frequently", "used", "in...
PMC11627398	Pearson correlation analysis was used to calculate the correlation coefficients using the “cor” R package.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Pearson", "correlation", "analysis", "was", "used...
PMC11363012	A complete picture requires a comparison of metabolite and biosynthetic gene localization.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "complete", "picture", "requires", "a", "comparison", "of", "metabolite", "a...
PMC9545474	The reaction was stirred at room temperature, under nitrogen, for 4 hours.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "reaction", "was", "stirred", "at", "room", "temperature", ...
PMC11753949	However, it is organized in morphological and functional distinct domains, more so in specialized cells such as neurons.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "it", "...
PMC11307990	Next, cells were equilibrated by incubation with 100 μL of TDT equilibration buffer for 30 min and then were incubated with 50 μL of labeling solution at 37 °C in the dark for 60 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11533140	Furthermore, SAR analyses led to the discovery of a candidate, 17p, with excellent kinase inhibitory activity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Furthermore", ",", "SAR", "analys...
PMC11228511	The lamin C antibody that we used was specific; there was no binding of the antibody to Lmna cells, nor was there any binding of the antibody to other nuclear lamins on western blots.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7582629	The PCA score plots, constructed by plotting the score coefficients in the plane of the PCs, can be used to visualize cell groups.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11365983	Total RNA was isolated with RNeasy Plus Mini Kit (Qiagen), quantified and used for cDNA synthesis with Primescript RT Master Mix (Clontech).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6487404	A reduction in the TEER recorded across a monolayer indicates the dilation of tight junctions or a disruption of the monolayer (16, 17).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11322866	To further confirm cellular senescence, we used TEM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "further", "confirm", "cellular", "senescence", ",", "we", "used", "TEM", "." ] } ]
PMC11087766	Together, this provides evidence that PicA forms part of the import machinery through which imported proteins pass and supports a mechanism in which proteins are targeted to PicA for translocation across the phage nuclear shell.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11541241	Schematic illustration of TOR‐based therapies for disease control.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Schematic", "illustration", "of", "TOR‐based", "therapies", "for", "disease", "control", "." ] } ]
PMC10204952	In the current study, we investigated the effects of normal adipocyte-conditioned cell culture media (AD-CM) and cancer-associated adipocyte-conditioned cell culture media (CAA-CM) on S1P treatment of triple-negative breast cancer (TNBC) cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11506670	Our prospective, targeted, next-generation sequencing study of EGFR pathway genes in tumors obtained from Filipino young-onset colorectal cancer patients confirmed extensive inter- and intratumor heterogeneity, and identified dozens of novel coding region mutations, many of which have not been reported in the literature, or remain only partially characterized.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10654497	The gene expression profiles of 10 SFRGs in normal tissues and lung adenocarcinoma samples from the TCGA cohort are depicted in a heatmap. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11532793	We observed that the Gibbs and bootstrap RTA-dispersions were highly correlated but that the bootstrap values were on average higher (Figure 1a).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC7602170	So, the RAS-ERK pathway regulates mTORC1 passing the TSC1/TSC2 complex .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "So", ",", "the", "RAS-ERK", "pathway", "regulates", "mTORC1", "passing", "the", "TSC1...
PMC8345486	Adenosine inhibits the biological functions of various immune cells in the tumor environment by interacting with adenosine receptors located on the cell surface, mainly on leukocytes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Image: Summary/Conclusion: Initial 2G-TKI lead to similar outcomes as imatinib in patients with CML presenting in accelerated-phase except higher therapy responses.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Image",...
PMC9684669	F, G) Cellular thermal shift assay (CETSA) for the binding of terfenadine to CAMKIID in MDR ovarian cancer cell lysate. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11627060	SEM images (Figure 2e and f) analysis was performed on the synthesized BSA NPs and the formulated TQ–BSA NPs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "SEM", ...
PMC11772449	Taken together, our findings suggest that pirfenidone can work in concert with Sora to intensify its anti-tumor effect on hepatocellular carcinoma, thereby offering a novel therapeutic approach for Sora-mediated tumor treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5261804	Sensitivity to the MAPK inhibitor AZD6244 is highly correlated with PRKDC-TP53 interaction essentiality, which is consistent with the well established role of p38-MAPK in cell cycle arrest in response to DNA damage [51–53].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10898159	The V558Δ; V653A mutant mislocalization of Golgi, and lead to the enhanced activation of STAT3 and STAT5, although no differences were seen in MAPK or PI3K pathway activation, therefore, contributing to the increased tumor oncogenesis, compared to control mice with a single V558Δ Kit mutation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8009078	TMPRSS2 is one of the crucial targets to stop SARS-CoV-2 infection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "TMPRSS2", "is", "one", "of", "the", "crucial", "targets", "to", "stop", "SARS-CoV-2",...
PMC10024132	The nucleic acid sequence of blinatumomab was extracted from patent US7635472B2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "nucleic", "acid", "sequence", "of", "blinatumomab", "was", "extracted", "from", ...
PMC9429973	These findings suggest that in patients where FLC ratio ≥100 is the only myeloma-defining event, other high-risk features as well as the evolution of FLCs over time should be considered in the decision to start a patient on treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11632064	Representative films of cytokine arrays and HRP chemiluminescence associated with the presence of cytokines in conditioned media from MeWo cultures.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "Representative", "films",...
PMC11756514	WTA is important for several reasons, including adhesion and colonization (61), cell wall integrity, antibiotic resistance, and immune interactions (62).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11705547	However, if exogenous lipids are also in short supply, the cells may synthesize FAs de novo to ensure sufficient intracellular lipid content.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11519567	Scale bars, 5 μm.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bars", ",", "5", "μm", "." ] } ]
PMC8633974	The gRNAs targeting genetically conserved and overlapping tat/rev exons maximized CRISPR-based attenuation of HIV-1 infection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "gRNAs", "targeting", "genetically", "conserved", "and", ...
PMC11721277	ESI-MS m/z calculated for C35H38N4O7 [M+H]: 627.3, for C36H40N4O9 [M+HCOOH+H]: 673.3.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ESI-MS", "m/z", "calculated", "for", "...
PMC9429973	As of the data cutoff date (10 SEP 2021), median follow up was 7.95 months (IQR 6.11-11.86).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9895440	The remaining samples were pooled into 2 pools (2–3 mice) per condition (intergenic n = 5 mice, Snx9 KO n = 6 mice).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11307990	We constructed DNA nanotapes with the ability to adsorb SUN on the surface, enabling long retention and RTK inhibition on the cell membrane and thereby enhancing the killing of tumor cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9812014	An in vitro investigation found three alkaloids with anti-HCoV-OC43 potential in MRC-5 cells: tetrandrine (TET), fangchinoline (FAN), and cepharanthine (CEP).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11033180	H, H′, and H″) Double immunolabeling for Plexin A2 (green) and ChAT (red) in the myenteric plexus of rat distal colon.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10114490	This cell line combines the expression of large-T antigen with a polycistronic vector containing HNF4A, HNF1A and FOXA3 cDNA controlled by seven tandem copies of a tetracycline responsive element (TetO-HHFG, Additional file 1: Fig. S1A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5600151	Polyethylene glycol (PEG) is frequently used to increase plasma circulation time and tumor accumulation through the enhanced permeability and retention (EPR) effect .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC7338939	The optimal schedule of every animal model is presented in Table 4 for the 15 days of therapy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "optimal", "schedule", "of", "ev...
PMC11361748	The source data used to derive the numerical values reported here can be found in S1 Data.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "source", "data", "used", "to", "deri...
PMC11701801	After 4 days, cell viability was measured in the CellTiter-Glo Luminescent Cell Viability Assay (Promega, G7571).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "4", "days", "...
PMC6642070	MDM2 and p53 proteins assessed by western blotting. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "MDM2", "and", "p53", "proteins", "assessed", "by", "western", "blotting", ".", "(" ] } ]
PMC10470467	The above analysis showed that RIPK1, JAK1, and CHMP7 are all significantly highly expressed in tumor tissue compared to normal tissue.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC11678448	Our previous work demonstrated that, in a goat bronchial epithelial cell infection model, the P. multocida serotype D (Pm-HN01) strain caused a greater number of non-adherent cells and more pronounced morphological changes compared to the P. multocida serotype A (Pm-HN02) strain.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Results: 10 pts with R/R DLBCL were enrolled.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "10", "pts", "with", "R/R", "DLBCL", "were", "enrolled", "." ] } ]
PMC11708541	Treatment usually emphases on speedy recovery from attacks, reduced radiographic and clinical relapses, reducing the progression of the disease.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Treatment", "usually", ...
PMC11361748	Classic examples of adaptation to stress include the photoprotective pigmentation that follows UV radiation in skin and adaptive and innate immune cell responses .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Classic...
PMC9684669	J, K) Doxorubicin intracellular accumulation in MDR ovarian cancer cells or its parental sensitive A2780 cells treated for 6 hours with 2 µM doxorubicin (Dox), 5 µM terfenadine (Ter), or both.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	R. Owen, H. McCarthy, S. Rule, S. D’Sa, S. Thomas, O. Tournilhac, F. Forconi, M. José Kersten, P. Luigi Zinzani, S. Iyengar, J. Kothari, M. Minnema, E. Kastritis, B. Cheson, H. Walter, D. Greewald, R. Calvo, C.-C. Wun, R. Furman St. James’s University Hospital, Leeds; Royal Bournemouth Hospital, Bournemouth; Plymouth University Medical School, Plymouth, United Kingdom; AstraZeneca, Mississauga, Ontario, Canada; University College London Hospitals NHS Trust, London, United Kingdom; MD Anderson Cancer Center, Houston, TX, United States of America; University of Southampton Hospital Trust, Southampton, United Kingdom; Amsterdam University Medical Centers, University of Amsterdam, Cancer Center Amsterdam, Amsterdam, Netherlands; Institute of Hematology University of Bologna, Bologna, Italy; Royal Marsden Hospital, London; Churchill Hospital, Oxford, United Kingdom; University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands; on behalf of the Lunenburg Lymphoma Phase I/II Consortium – HOVON/LLPC, Utrecht, Netherlands; National and Kapodistrian University of Athens, Athens, Greece; Georgetown University Hospital, Lombardi Comprehensive Cancer Center, Washington, DC, United States of America; Ernest and Helen Scott Haematological Research Institute and Leicester Cancer Research Centre, University of Leicester, Leicester, United Kingdom; Cancer Center of Santa Barbara, Santa Barbara; AstraZeneca, Gaithersburg, MD; AstraZeneca, South San Francisco; Weill Cornell Medical College, New York Presbyterian Hospital, New York, NY, United States of America Background: Bruton tyrosine kinase (BTK) inhibitors are effective in the treatment of Waldenström macroglobulinemia (WM).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11794568	but its specific functions and regulatory mechanisms are still incompletely understood in many aspects.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "but", "its", "specific", "functions", "and", "regulatory", "mechanisms...
PMC11726183	TOF HRMS (m/z): [M + H], calcd: 424.1272, found: 424.1272. %	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "TOF", "HRMS", "(", "m/z", "...
PMC11488203	Protein aliquots of the corresponding exosomes were quantified using the colorimetric BCA-assay (Thermo Scientific, Schwerte, Germany).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Protein", "aliquots", "of", ...
PMC10114490	Only ABCB6, a member of the ATP-binding cassette (ABC) transporter superfamily and related to drug resistance, out of 103 genes included in the database was significantly upregulated in HepG2 cells compared to diHLC-T. In fact, we found a significant increase in diHLC-T mRNA encoding enzymes participating in reduced glutathione transfer (Fig. 6D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11335267	Sympathetic activity regulated by the hypothalamic POMC system promotes lipolysis and glucose uptake in white and brown adipose tissues, respectively ; enhances hepatic glucose production and glucose uptake in muscle , and modulates pancreatic islet function by affecting insulin and glucagon secretion .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11040965	Decitabine treatment of U266 cells resulted in increases of cells staining positive for Z (P = 0.0313), LMP2 (P = 0.0469), LMP7 (P = 0.0313) and LMP10 (P = 0.0156) (Fig. 5A), similar to the effects of miR29b mimic transfection.	[ { "tags": [ "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11783017	G–I) Representative flow cytometry plots and quantitative analysis of CD44CD62L TCM cells and CD44CD62L TEM cells in spleen. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "G", "–", ...
PMC9512971	Underlying diseases: chronic respiratory disease, chronic kidney disease, diabetes mellitus, hypertension, cardiovascular disease, and obesity (body mass index ≥ 30 kg/m).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11225860	Resistance to apoptosis, uncontrolled proliferation, resistance to cell cycle checkpoint activation, or the ability to reenter the cell cycle after extended periods in G0 are all known hallmarks of cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11787651	The most widely recognized histone modifications are lysine methylation and acetylation, both of which play major roles in DNA binding, gene regulation, and chromosomal compaction (10, 11).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Estimated 1-year OS and PFS were 83% and 61% respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Estimated", "1-year", "OS", "and", "PFS", "were", "83", "%", "and", "61", ...
PMC11551844	Other absorption frequencies were observed for cyclic methylene groups (CH2)n at 1462 cm, gem-dimethyl (–CH(CH3)2) group at 1380 cm and C–OH (secondary alcohol) at 1052 cm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10391797	HDACi can influence tumor immunogenicity, the microenvironment, and the functional activity of specific immune cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "HDACi", "can", "influence", "tumor", "immunogenic...
PMC9429973	Results: In a kinome scan, GB5121 exhibited high kinase selectivity against 349 kinases with only TEC/TXK demonstrating >50% inhibition at 1 µM; additionally, GB5121 did not inhibit phosphorylation of EGFR in a cell-based assay.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9960565	A light gray hygroscopic powder was obtained with a yield of 56% (0.21 g).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "light", "gray", "hygroscopic", "powder", ...
PMC8740518	The high demand for EAAs is also reflected in the upregulation of EAA transporters that are evident in many cancers (Lieu et al., 2020).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11429241	Scaffold-based systems offer a promising approach to overcoming these challenges in cancer research.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scaffold-based", "systems", "offer", "a", "promising", "approach", "to", "o...
PMC11281366	Taken together, our results indicate that while the downregulation of miRNA26a during HIV-1 infection requires viral gene expression, this regulation does not appear to be dependent on HIV-1 accessory gene expression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11732628	Following the transfection with miR-490-3p mimic, it was found that 143B cell proliferation, migration, and invasion were inhibited, while the cell apoptotic levels and cell-cycle arrest were promoted, accompanied with decreased B cell lymphoma protein-2 (Bcl-2) protein expression, and increased protein expressions of Bcl-2-associated X (Bax), cleaved caspase-3, and cleaved caspase-9.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11532793	When bootstrap samples were generated, the results were even more stable with little change in statistical power with increasing number of technical samples.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11637276	SB202190 from APExBIO.	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "SB202190", "from", "APExBIO", "." ] } ]
PMC11786704	However, due to the limited ability of PC to be internalized by cells, free PC is less effective in entering cells to inhibit the p38 MAPK signaling pathway, which restricts its function.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11777207	C and D) Expression of PD-L1 from the MIGR1 MSCV constructs in Pdl1 GM-CSF–derived BMDCs at day 7.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "C", "and", "D", ...
PMC9688728	Our conclusions comply with the findings of an impressive heterogeneity study of the HeLa cell line, demonstrating a tight connection between late passages, omics variations (including cell morphology, doubling time, karyotype, and mRNA and protein expression, as well as protein turnover rate), and fully materialized phenotypic differences .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9878278	Gene Expression of TGFB1 and INHBA (Activin A) was measured at 48 hpi using qRT-PCR and fold change was calculated as compared to mock-infected cells after normalizing to GAPDH. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11529598	NC membrane was blocked in 5% nonfat milk and incubated with indicated primary antibody.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "NC", "membrane", "was", "blocked", "in", "5", "%", "n...
PMC11463018	16b, a derivative of 10 in which its cyclopropylacyl group was replaced with phenylhydroxamic acid exhibited excellent inhibitory activity against HDAC6 (IC50 = 8.75 nM) and retained moderate inhibitory activity against JAK1 enzyme (IC50 = 146 nM).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11794847	Also, they detected T cell responses and identified the related T cell receptors in six patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Also", ",", "they", "detected", "T", "cell"...
PMC9444294	IHC, immunohistochemistry.	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "IHC", ",", "immunohistochemistry", "." ] } ]
PMC11705862	Efficient protein-level downregulation of CD59 expression was also detected in both the noradrenaline secretion assay- and p-tau/Cdk5 expression experiments (Fig. 2I, quantification in J), consistent with mRNA results.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5673955	P ≤ 0.05 was considered significant by Student's t‐test.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "P", "≤", "0.05", "was", "considered", "significant", "by", "Student", "'s", "t‐test", "." ...
PMC11541409	Although this trial was terminated, it provides potential of ADC for the treatment of GIST with wild-type KIT .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Although", "this", "trial", "was"...
PMC10203589	In terms of the mechanism of ccRCC progression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "terms", "of", "the", "mechanism", "of", "ccRCC", "progression", "." ] } ]
PMC11790971	Increased heterogeneity is shown among the transfected cell line clones due to random gene integration and the gene amplification process, leading to varying product quality attributes (QAs) and process performance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Methods: In this study, pts were dosed with lisaftoclax orally once daily in 28-day cycles.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "In", "this", "study", ",", ...
PMC11585254	Data represent the mean ± S.D. from three independent experiments. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "represent", "the", "mean", "±", "S.D.", "from", "three", "independent", "expe...
PMC8409415	The knockdown of NF‐κB‐p65 and phosphorylated NF‐κB‐p65 expression was confirmed by WB analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "knockdown", "of", "NF‐κB‐p65", "and", "phosphorylated", "NF‐κB‐p65", ...

PMC10719213

The present study demonstrates that in T-cell lines and in ex vivo cultured lymphocytes, cladribine did not affect the integrity of the mitochondrial genome and was not mutagenic to mtDNA.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10482220

Fig. 5 A clearly established that endogenous G3BP was efficiently coimmunoprecipitated with GFP-G3BP (lane 4), GFP-S149A (lane 6), GFP-S332A (lane 10), and GFP-S232E (lane 12).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11656048

MDA, the final product of lipid peroxidation, is an important end product of lipid ROS (Yin et al., 2022).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC11769516

The effect of fumonidins on the ENS depends on the gastrointestinal segment and the type of intestinal plexus .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "effect", "of", "fumonidins", "o...

PMC9583612

As technology—especially CEMS flux algorithms and emission localization capability—improves, it would be possible to provide real-time estimates of site-level methane emissions that can be used in lieu of engineering-based inventory estimates for each site.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11774112

PLA was obtained from Daigang Biological Engineering (Jinan, China).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PLA", "was", "obtained", "from", "Daigang", "Biological", "Engineering", "(", "J...

PMC9878562

Transmigration towards 10 nM CXCL12 was performed and calculated as described in Figure 1 . (

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PMC9429973

This might eventually allow for biology-informed treatment development for pts in this high-risk disease setting.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "might", "eventually", "allow", "for", "biology-informed",...

PMC5311252

ZBTB7A has been shown to be a TS in prostate cancer as ZBTB7A activity results in increased RB1 stability.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ZBTB7A", "has", "been", "shown", ...

PMC11754432

To investigate the role of ALOX15B in psoriasis, keratinocytes in vitro were treated with a cocktail of IL-17A, interferon (IFN)γ and tumour necrosis factor (TNF)α to induce a psoriasis-like phenotype following 72 h of transfection with control or ALOX15B siRNA.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Ruxolitinib was more frequently used in patients who underwent to hospital than managed at home. (

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Ruxolitinib", "was", "more", "frequently", "used", "in...

PMC11627398

Pearson correlation analysis was used to calculate the correlation coefficients using the “cor” R package.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Pearson", "correlation", "analysis", "was", "used...

PMC11363012

A complete picture requires a comparison of metabolite and biosynthetic gene localization.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "complete", "picture", "requires", "a", "comparison", "of", "metabolite", "a...

PMC9545474

The reaction was stirred at room temperature, under nitrogen, for 4 hours.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "reaction", "was", "stirred", "at", "room", "temperature", ...

PMC11753949

However, it is organized in morphological and functional distinct domains, more so in specialized cells such as neurons.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "it", "...

PMC11307990

Next, cells were equilibrated by incubation with 100 μL of TDT equilibration buffer for 30 min and then were incubated with 50 μL of labeling solution at 37 °C in the dark for 60 min.

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PMC11533140

Furthermore, SAR analyses led to the discovery of a candidate, 17p, with excellent kinase inhibitory activity.

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PMC11228511

The lamin C antibody that we used was specific; there was no binding of the antibody to Lmna cells, nor was there any binding of the antibody to other nuclear lamins on western blots.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC7582629

The PCA score plots, constructed by plotting the score coefficients in the plane of the PCs, can be used to visualize cell groups.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...

PMC11365983

Total RNA was isolated with RNeasy Plus Mini Kit (Qiagen), quantified and used for cDNA synthesis with Primescript RT Master Mix (Clontech).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC6487404

A reduction in the TEER recorded across a monolayer indicates the dilation of tight junctions or a disruption of the monolayer (16, 17).

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PMC11322866

To further confirm cellular senescence, we used TEM.

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PMC11087766

Together, this provides evidence that PicA forms part of the import machinery through which imported proteins pass and supports a mechanism in which proteins are targeted to PicA for translocation across the phage nuclear shell.

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PMC11541241

Schematic illustration of TOR‐based therapies for disease control.

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PMC10204952

In the current study, we investigated the effects of normal adipocyte-conditioned cell culture media (AD-CM) and cancer-associated adipocyte-conditioned cell culture media (CAA-CM) on S1P treatment of triple-negative breast cancer (TNBC) cells.

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PMC11506670

Our prospective, targeted, next-generation sequencing study of EGFR pathway genes in tumors obtained from Filipino young-onset colorectal cancer patients confirmed extensive inter- and intratumor heterogeneity, and identified dozens of novel coding region mutations, many of which have not been reported in the literature, or remain only partially characterized.

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PMC10654497

The gene expression profiles of 10 SFRGs in normal tissues and lung adenocarcinoma samples from the TCGA cohort are depicted in a heatmap. (

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PMC11532793

We observed that the Gibbs and bootstrap RTA-dispersions were highly correlated but that the bootstrap values were on average higher (Figure 1a).

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PMC7602170

So, the RAS-ERK pathway regulates mTORC1 passing the TSC1/TSC2 complex .

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PMC8345486

Adenosine inhibits the biological functions of various immune cells in the tumor environment by interacting with adenosine receptors located on the cell surface, mainly on leukocytes.

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PMC9429973

Image: Summary/Conclusion: Initial 2G-TKI lead to similar outcomes as imatinib in patients with CML presenting in accelerated-phase except higher therapy responses.

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PMC9684669

F, G) Cellular thermal shift assay (CETSA) for the binding of terfenadine to CAMKIID in MDR ovarian cancer cell lysate. (

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PMC11627060

SEM images (Figure 2e and f) analysis was performed on the synthesized BSA NPs and the formulated TQ–BSA NPs.

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PMC11772449

Taken together, our findings suggest that pirfenidone can work in concert with Sora to intensify its anti-tumor effect on hepatocellular carcinoma, thereby offering a novel therapeutic approach for Sora-mediated tumor treatment.

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PMC5261804

Sensitivity to the MAPK inhibitor AZD6244 is highly correlated with PRKDC-TP53 interaction essentiality, which is consistent with the well established role of p38-MAPK in cell cycle arrest in response to DNA damage [51–53].

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PMC10898159

The V558Δ; V653A mutant mislocalization of Golgi, and lead to the enhanced activation of STAT3 and STAT5, although no differences were seen in MAPK or PI3K pathway activation, therefore, contributing to the increased tumor oncogenesis, compared to control mice with a single V558Δ Kit mutation.

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PMC8009078

TMPRSS2 is one of the crucial targets to stop SARS-CoV-2 infection.

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PMC10024132

The nucleic acid sequence of blinatumomab was extracted from patent US7635472B2.

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PMC9429973

These findings suggest that in patients where FLC ratio ≥100 is the only myeloma-defining event, other high-risk features as well as the evolution of FLCs over time should be considered in the decision to start a patient on treatment.

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PMC11632064

Representative films of cytokine arrays and HRP chemiluminescence associated with the presence of cytokines in conditioned media from MeWo cultures.

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PMC11756514

WTA is important for several reasons, including adhesion and colonization (61), cell wall integrity, antibiotic resistance, and immune interactions (62).

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PMC11705547

However, if exogenous lipids are also in short supply, the cells may synthesize FAs de novo to ensure sufficient intracellular lipid content.

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PMC11519567

Scale bars, 5 μm.

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PMC8633974

The gRNAs targeting genetically conserved and overlapping tat/rev exons maximized CRISPR-based attenuation of HIV-1 infection.

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PMC11721277

ESI-MS m/z calculated for C35H38N4O7 [M+H]: 627.3, for C36H40N4O9 [M+HCOOH+H]: 673.3.

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PMC9429973

As of the data cutoff date (10 SEP 2021), median follow up was 7.95 months (IQR 6.11-11.86).

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PMC9895440

The remaining samples were pooled into 2 pools (2–3 mice) per condition (intergenic n = 5 mice, Snx9 KO n = 6 mice).

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PMC11307990

We constructed DNA nanotapes with the ability to adsorb SUN on the surface, enabling long retention and RTK inhibition on the cell membrane and thereby enhancing the killing of tumor cells.

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PMC9812014

An in vitro investigation found three alkaloids with anti-HCoV-OC43 potential in MRC-5 cells: tetrandrine (TET), fangchinoline (FAN), and cepharanthine (CEP).

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PMC11033180

H, H′, and H″) Double immunolabeling for Plexin A2 (green) and ChAT (red) in the myenteric plexus of rat distal colon.

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PMC10114490

This cell line combines the expression of large-T antigen with a polycistronic vector containing HNF4A, HNF1A and FOXA3 cDNA controlled by seven tandem copies of a tetracycline responsive element (TetO-HHFG, Additional file 1: Fig. S1A).

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PMC5600151

Polyethylene glycol (PEG) is frequently used to increase plasma circulation time and tumor accumulation through the enhanced permeability and retention (EPR) effect .

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PMC7338939

The optimal schedule of every animal model is presented in Table 4 for the 15 days of therapy.

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PMC11361748

The source data used to derive the numerical values reported here can be found in S1 Data.

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PMC11701801

After 4 days, cell viability was measured in the CellTiter-Glo Luminescent Cell Viability Assay (Promega, G7571).

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PMC6642070

MDM2 and p53 proteins assessed by western blotting. (

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PMC10470467

The above analysis showed that RIPK1, JAK1, and CHMP7 are all significantly highly expressed in tumor tissue compared to normal tissue.

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PMC11678448

Our previous work demonstrated that, in a goat bronchial epithelial cell infection model, the P. multocida serotype D (Pm-HN01) strain caused a greater number of non-adherent cells and more pronounced morphological changes compared to the P. multocida serotype A (Pm-HN02) strain.

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PMC9429973

Results: 10 pts with R/R DLBCL were enrolled.

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PMC11708541

Treatment usually emphases on speedy recovery from attacks, reduced radiographic and clinical relapses, reducing the progression of the disease.

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PMC11361748

Classic examples of adaptation to stress include the photoprotective pigmentation that follows UV radiation in skin and adaptive and innate immune cell responses .

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PMC9684669

J, K) Doxorubicin intracellular accumulation in MDR ovarian cancer cells or its parental sensitive A2780 cells treated for 6 hours with 2 µM doxorubicin (Dox), 5 µM terfenadine (Ter), or both.

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PMC9429973

R. Owen, H. McCarthy, S. Rule, S. D’Sa, S. Thomas, O. Tournilhac, F. Forconi, M. José Kersten, P. Luigi Zinzani, S. Iyengar, J. Kothari, M. Minnema, E. Kastritis, B. Cheson, H. Walter, D. Greewald, R. Calvo, C.-C. Wun, R. Furman St. James’s University Hospital, Leeds; Royal Bournemouth Hospital, Bournemouth; Plymouth University Medical School, Plymouth, United Kingdom; AstraZeneca, Mississauga, Ontario, Canada; University College London Hospitals NHS Trust, London, United Kingdom; MD Anderson Cancer Center, Houston, TX, United States of America; University of Southampton Hospital Trust, Southampton, United Kingdom; Amsterdam University Medical Centers, University of Amsterdam, Cancer Center Amsterdam, Amsterdam, Netherlands; Institute of Hematology University of Bologna, Bologna, Italy; Royal Marsden Hospital, London; Churchill Hospital, Oxford, United Kingdom; University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands; on behalf of the Lunenburg Lymphoma Phase I/II Consortium – HOVON/LLPC, Utrecht, Netherlands; National and Kapodistrian University of Athens, Athens, Greece; Georgetown University Hospital, Lombardi Comprehensive Cancer Center, Washington, DC, United States of America; Ernest and Helen Scott Haematological Research Institute and Leicester Cancer Research Centre, University of Leicester, Leicester, United Kingdom; Cancer Center of Santa Barbara, Santa Barbara; AstraZeneca, Gaithersburg, MD; AstraZeneca, South San Francisco; Weill Cornell Medical College, New York Presbyterian Hospital, New York, NY, United States of America Background: Bruton tyrosine kinase (BTK) inhibitors are effective in the treatment of Waldenström macroglobulinemia (WM).

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PMC11794568

but its specific functions and regulatory mechanisms are still incompletely understood in many aspects.

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PMC11726183

TOF HRMS (m/z): [M + H], calcd: 424.1272, found: 424.1272. %

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PMC11488203

Protein aliquots of the corresponding exosomes were quantified using the colorimetric BCA-assay (Thermo Scientific, Schwerte, Germany).

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PMC10114490

Only ABCB6, a member of the ATP-binding cassette (ABC) transporter superfamily and related to drug resistance, out of 103 genes included in the database was significantly upregulated in HepG2 cells compared to diHLC-T. In fact, we found a significant increase in diHLC-T mRNA encoding enzymes participating in reduced glutathione transfer (Fig. 6D).

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PMC11335267

Sympathetic activity regulated by the hypothalamic POMC system promotes lipolysis and glucose uptake in white and brown adipose tissues, respectively ; enhances hepatic glucose production and glucose uptake in muscle , and modulates pancreatic islet function by affecting insulin and glucagon secretion .

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PMC11040965

Decitabine treatment of U266 cells resulted in increases of cells staining positive for Z (P = 0.0313), LMP2 (P = 0.0469), LMP7 (P = 0.0313) and LMP10 (P = 0.0156) (Fig. 5A), similar to the effects of miR29b mimic transfection.

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PMC11783017

G–I) Representative flow cytometry plots and quantitative analysis of CD44CD62L TCM cells and CD44CD62L TEM cells in spleen. (

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PMC9512971

Underlying diseases: chronic respiratory disease, chronic kidney disease, diabetes mellitus, hypertension, cardiovascular disease, and obesity (body mass index ≥ 30 kg/m).

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PMC11225860

Resistance to apoptosis, uncontrolled proliferation, resistance to cell cycle checkpoint activation, or the ability to reenter the cell cycle after extended periods in G0 are all known hallmarks of cancer.

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PMC11787651

The most widely recognized histone modifications are lysine methylation and acetylation, both of which play major roles in DNA binding, gene regulation, and chromosomal compaction (10, 11).

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PMC9429973

Estimated 1-year OS and PFS were 83% and 61% respectively.

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PMC11551844

Other absorption frequencies were observed for cyclic methylene groups (CH2)n at 1462 cm, gem-dimethyl (–CH(CH3)2) group at 1380 cm and C–OH (secondary alcohol) at 1052 cm.

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PMC10391797

HDACi can influence tumor immunogenicity, the microenvironment, and the functional activity of specific immune cells.

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PMC9429973

Results: In a kinome scan, GB5121 exhibited high kinase selectivity against 349 kinases with only TEC/TXK demonstrating >50% inhibition at 1 µM; additionally, GB5121 did not inhibit phosphorylation of EGFR in a cell-based assay.

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PMC9960565

A light gray hygroscopic powder was obtained with a yield of 56% (0.21 g).

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PMC8740518

The high demand for EAAs is also reflected in the upregulation of EAA transporters that are evident in many cancers (Lieu et al., 2020).

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PMC11429241

Scaffold-based systems offer a promising approach to overcoming these challenges in cancer research.

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PMC11281366

Taken together, our results indicate that while the downregulation of miRNA26a during HIV-1 infection requires viral gene expression, this regulation does not appear to be dependent on HIV-1 accessory gene expression.

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PMC11732628

Following the transfection with miR-490-3p mimic, it was found that 143B cell proliferation, migration, and invasion were inhibited, while the cell apoptotic levels and cell-cycle arrest were promoted, accompanied with decreased B cell lymphoma protein-2 (Bcl-2) protein expression, and increased protein expressions of Bcl-2-associated X (Bax), cleaved caspase-3, and cleaved caspase-9.

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PMC11532793

When bootstrap samples were generated, the results were even more stable with little change in statistical power with increasing number of technical samples.

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PMC11637276

SB202190 from APExBIO.

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PMC11786704

However, due to the limited ability of PC to be internalized by cells, free PC is less effective in entering cells to inhibit the p38 MAPK signaling pathway, which restricts its function.

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PMC11777207

C and D) Expression of PD-L1 from the MIGR1 MSCV constructs in Pdl1 GM-CSF–derived BMDCs at day 7.

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PMC9688728

Our conclusions comply with the findings of an impressive heterogeneity study of the HeLa cell line, demonstrating a tight connection between late passages, omics variations (including cell morphology, doubling time, karyotype, and mRNA and protein expression, as well as protein turnover rate), and fully materialized phenotypic differences .

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PMC9878278

Gene Expression of TGFB1 and INHBA (Activin A) was measured at 48 hpi using qRT-PCR and fold change was calculated as compared to mock-infected cells after normalizing to GAPDH. (

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PMC11529598

NC membrane was blocked in 5% nonfat milk and incubated with indicated primary antibody.

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PMC11463018

16b, a derivative of 10 in which its cyclopropylacyl group was replaced with phenylhydroxamic acid exhibited excellent inhibitory activity against HDAC6 (IC50 = 8.75 nM) and retained moderate inhibitory activity against JAK1 enzyme (IC50 = 146 nM).

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PMC11794847

Also, they detected T cell responses and identified the related T cell receptors in six patients.

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PMC9444294

IHC, immunohistochemistry.

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PMC11705862

Efficient protein-level downregulation of CD59 expression was also detected in both the noradrenaline secretion assay- and p-tau/Cdk5 expression experiments (Fig. 2I, quantification in J), consistent with mRNA results.

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PMC5673955

P ≤ 0.05 was considered significant by Student's t‐test.

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PMC11541409

Although this trial was terminated, it provides potential of ADC for the treatment of GIST with wild-type KIT .

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PMC10203589

In terms of the mechanism of ccRCC progression.

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PMC11790971

Increased heterogeneity is shown among the transfected cell line clones due to random gene integration and the gene amplification process, leading to varying product quality attributes (QAs) and process performance.

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PMC9429973

Methods: In this study, pts were dosed with lisaftoclax orally once daily in 28-day cycles.

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PMC11585254

Data represent the mean ± S.D. from three independent experiments. (

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PMC8409415

The knockdown of NF‐κB‐p65 and phosphorylated NF‐κB‐p65 expression was confirmed by WB analysis.

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