OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC9776316	A similar trend was also observed in the colony formation; the combination of XRCC4 knockdown and cisplatin treatment strongly abolished the colony formation potential in the cisplatin-resistant ovarian cancer cell lines, supporting the role of XRCC4 in the regulation of cisplatin sensitivity (Figure 2f,g).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11599565	Panel A: Neuromelanin-expressing cells in SKOV3 wildtype and its cisplatin resistant subline.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Panel", "A", ":", "Neuromelanin-expressing", "cells", "in", "SKOV3", ...
PMC11703992	In GCA samples, CD4+ Memory T cells showed high similarity to them in the old samples.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "GCA", "samples", ",", "CD4", ...
PMC10237474	For glycosylated proteins, 5 μg of protein was deglycosylated using either non-reduced or reduced rapid PNGase F in a total reaction volume of 20 μL at 50°C for 20–30 min.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6222635	The 4% paraformaldehyde was removed, and the cells were washed three times with PBS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "4", "%", "paraformaldehyde", "was", "removed", ...
PMC11760643	More recently, our group has used this mAb to demonstrate the role of donor (human) P2X7 in promoting graft‐versus‐host disease (GVHD) in humanised mice .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11767725	A flowchart of the complex interactions between AGE-RAGE pathway and the skin is illustrated in Figure 2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "flowchart", "of", "the", "complex", "i...
PMC11612626	RPMI-8226, ARH-77, and U266 cells were incubated with each compound at the indicated time and concentration.	[ { "tags": [ "B-CellLine", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "RPMI-8226", ",", "ARH-7...
PMC10243817	Although TGF-βR3 function has been studied in myoblasts (28, 29), its function in airway epithelial cells has yet to be determined.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC8711270	HEK293E and HEK293-6E is widely used in TGE as the use of plasmids with Epstein-Barr virus oriP significantly improves TGE (Pham et al., 2006).	[ { "tags": [ "B-CellLine", "O", "B-CellLine", "I-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11222184	Interestingly, XL-888 treatment led to an upregulation in the expression of hypoxia signaling-related genes HMOX1 and SLC2A1, whereas Debio0932 treatment resulted in a downregulation of CA9 and HMOX1 expression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11655498	In contrast, its absence impairs reactivation triggered by inducers (Liu and Cohen, 2016).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "contrast", ",", "its", "absence", "im...
PMC11759751	P < 0.05; P < 0.01; *P < 0.001 Low-dose chidamide did not affect the proliferation, apoptosis and anti-tumor ability of prepared CD19 CAR T cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	One pt required VEN dose reduction due to cytopenias.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "One", "pt", "required", "VEN", "dose", "reduction", "due", "to", "cytopenias", "." ] } ]
PMC11055323	b Representative images of SS18-EGFP and SS18-SSX1-EGFP fusion protein overexpressed via lentiviral infection in BJ fibroblasts.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "b", "Representative", "images", "of", "SS18-EGFP", "an...
PMC9429973	The disease burden and response to therapy rely on a dynamic system: the hematopoietic stem cells (HSC) receptor characteristics (baseline degree of immune dysfunction, bone marrow microenvironment, bone marrow and gut microbiomes); the HSC donor characteristics and graft relative cellular composition.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Given the high rate of progression of SCR, screening of SCR remains important, but differentiated strategies for screening and follow-up of SCR could be considered for low-risk or high-risk patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Percent without high school degree (HSD) reflects the education level within the pt’s zip code, which was stratified into 4 quartiles.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC7723249	Previous studies have suggested that the disease progression of viral hemorrhagic fevers could be due to a cytokine storm and high viremia .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Previous", "...
PMC7602170	The incidence rate was 10 to 15 per million per year.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "incidence", "rate", "was", "10", "to", "15", "per", "million", "per", "y...
PMC11087301	Another investigation of CTCs from breast cancer revealed that fluid shear stress promotes EMT in the epithelial CTCs and maintains mesenchymal CTCs by mechanistically activating JNK signaling.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11676169	KU70 acetylation levels were further increased under DNA-damaging conditions (Supplementary Figure S4) .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "KU70", "acetylation", "levels", "were", "further", "increased", "under...
PMC9454852	Calpain activity was determined in the absence or presence of 100 μM BOLD-100, and in the presence of a calpain inhibitor (PD150606).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11457557	According to a recent theory, TGF1 may have an essential role in the early stages of DKD development, and several miRNAs and long non-coding RNAs (lncRNAs) control the critical molecules in the TGF1 pathway.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6222635	The DPFs F1 and F3 exhibited significant anti-proliferation activity in a dose-dependent manner.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "DPFs", "F1", "and", "F3", "exhibited", "significant", "anti-prolifer...
PMC9429973	All but ELEVATE -TN study included patients previously treated with CLL.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "but", "ELEVATE", "-TN", "study", "included", "patients", "previously", "treated", ...
PMC11686380	Our findings, along with previous reports, contribute to uncover the pathophysiology of GAP43-associated neurodevelopmental diseases and highlight the crucial roles of GAP43 in brain development, particularly in dendritic arborization, dendritogenesis, and interhemispheric axon extension.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11469524	A previous study on Hela cells determined that the crosstalk is conferred by direct binding of p38 to ERK , as it demonstrated direct binding and no change in MEK phosphorylation.	[ { "tags": [ "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The effects of different concentrations of As2O3 on the expression of apoptosis related proteins Bcl-2, Bax, Caspas-3 and PARP were detected by ELISA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11699465	Colony formation assay to show the cell proliferation ability in 4T1 cells with TMEM199 knock down. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Colony", "formation", "assay", "to", "sh...
PMC8010066	The viability of P. aeruginosa was measured as log10 (CFU/well) in the co-culture with S. aureus.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "viability", "of", "P.", "aerugi...
PMC11462929	A black arrow indicates an interaction between MYC gene and N‐ME regions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "black", "arrow", "indicates", "an", "interaction", "between", "MYC", "gene"...
PMC11679033	Mycotoxins persist in these products’ post-processing, posing health risks via multiple exposure routes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Mycotoxins", "persist", "in", "these", "products", "’", "po...
PMC9780037	Storage at room temperature could be extended to 5 months.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Storage", "at", "room", "temperature", "could", "be", "extended", "to", "5", "months", "."...
PMC11676169	KU70 acetylation has been shown to impair c-NHEJ activity by modifying the KU70 lysine residues needed for binding dsDNA ends .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "KU70", "acetylation", "has",...
PMC5716223	Hsp27 and αB-Cry are key components of the myofibril structure, with a prominent role in skeletal muscle physio-pathology and in exercise-related adaptation to damaging contraction .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11422150	In assessing the systemic inflammatory response, hAMSC treatment reduced monocytic bone marrow-derived suppressor cells (M-MDSCs) and Ly6C-positive inflammatory macrophages in the bone marrow by flow cytometry and serum NO levels by ELISA assay.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4360730	Once determined, the required relationships are reported to the relevant ontologies using their designated format of issue submission.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Once", "determined", ",", "the", ...
PMC11297139	Through genome-wide chromatin structure and transcription profiling, we identify that the ARID1A condensate localizes to EWS/FLI1 target enhancers and induces long-range chromatin architectural changes by forming functional chromatin remodeling hubs at oncogenic target genes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10890307	After incubation, the cells were harvested by non-enzymatic treatment (EDTA-MOPS).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "incubation", ",", "the", "cells", "were", "harvested", "by", ...
PMC11765988	A linkage to DRB1 is a shared feature of sarcoidosis and lymphoma.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "linkage", "to", "DRB1", "is", "a", "shared", "feature", "of", "sarcoi...
PMC11301927	Most were male (71%), had clear cell RCC (88%) and had intermediate/poor risk disease (79%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11047729	The higher the concentration of CAUE, the better inhibiting properties it displayed toward hTERT.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "higher", "the", "concentration", "of", "CAUE", ",", ...
PMC11297139	Scale bar: 2 μm.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bar", ":", "2", "μm", "." ] } ]
PMC9429973	Patients in this study received an 8-week period of treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Patients", "in", "this", "study", "received", "an", "8-week", "period", "of", "treatment", ...
PMC10362265	The inconsistency between RG and SASA is likely to be resulted from the fact that the shape of the heterodimers and possibly the monomers are not ideally globular (Fig. 1), rendering RG measurements less informative about the shape than SASA measurements .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11617590	Mia PaCa‐2 cells were seeded at 4 × 10 cells/3 mL/well and were treated for 24 h with sulforaphane (SFN) at concentrations of 0, 25, and 100 μM. Protein expression of cMyc and β‐Actin were measured using Western blot analysis.	[ { "tags": [ "B-CellLine", "I-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC9429973	Statistical analyses were performed using codes suggested by the National Institute for Health and Care Excellence.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Statistical", "analyses", "were", "performed", "using", ...
PMC11721295	A P value associated with this statistic was also computed using an adaptive multilevel split Monte Carlo simulation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "P", "value", "associated", "with"...
PMC8164677	Binding Energy (kcal/mol) and Post-Dock Analysis of the Best Pose of Wedelolactone with Hepatocyte Growth Factor Receptor (cMET), Checkpoint Kinase 1 (Chk1), Ecto-5′-Nucleotidase (CD73), Mammalian Target of Rapamycin (mTOR1), Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2), Hypoxia-Inducible Factor 2-Alpha (HIF2α), Heat Shock Protein 60 (HSP60), Insulin Like Growth Factor (IGF1), P300/CBP-Associated Factor (PCAF), Bromodomain Protein 1 (Brd1) and Acetyl Transferase Tip (at Tip60) Abbreviations: ALA, alanine; ASN, asparagine; ASP, aspartic acid; ARG, arginine; CYS, cysteine; GLU, glutamic acid; GLY, glycine; GLN, glutamine; HIS, histidine; LYS, lysine; PHE, phenylalanine; SER, serine; THR, threonine; TRP, tryptophan; TYR, tyrosine; VAL, valine.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11088135	Similar results were observed in A172 cells (Supplementary Fig. 1).	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Similar", "results", "were", "observed", "in", "A172", "cells", "(", "S...
PMC11536589	However, PKF-118-310 effectively induced cell death in AsPC1-MR cells and KPC210-MR cells (Fig. 6C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "PKF-1...
PMC5034105	The findings in our study may have important clinical and epidemiological implications for this rapidly expanding viral epidemic.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "findings", "in", "our", "study"...
PMC11448304	Then, to validate these results, we used another lung adenocarcinoma cell line, H1299.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "I-CellLine", "I-CellLine", "O", "B-CellLine", "O" ], "tokens": [ "Then", ",", "to", "va...
PMC11552389	On day 24 post-transplantation, tumor samples were taken and weighed. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "On", "day", "24", "post-transplantation", ",", "tumor", "samples", "were", "take...
PMC7504302	The primary etiological factor of MPM is the past occupational and environmental exposure to the exogenous factor asbestos, which accounts for ~80% of the diagnosed cases .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9516401	These cases should be further investigated in the future.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "cases", "should", "be", "further", "investigated", "in", "the", "future", "." ] } ]
PMC11194678	Essential for mRNA transport and localization, STAU1 was found to organize RNA-containing granules destined for dendritic spines in mature hippocampal neurons (Mitsumori et al., 2017; Vessey et al., 2008).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11047729	IFN-α has also been shown to amplify graft-versus-leukemia (GVL) response in the case of allogeneic hematopoietic cell transplantation (HCT) for high-risk AML, which prevents leukemia relapse .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10914904	Finally, m5C methylation has been shown to improve the stability and proper folding of noncoding RNAs (ncRNAs).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Finally", ",", "m5C", ...
PMC11536589	AsPC1-MR cells or KPC210-MR cells were infected with the various lentiviral vectors.	[ { "tags": [ "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "AsPC1-MR", "cells", "or", "KPC210-MR", "cells", "were", "infected", ...
PMC11476837	Doxorubicin at 100 nM significantly reduced the viability of HL-60 cells (viability at 68%) (p < 0.001) and slightly reduced the viability of HL-60/DR cells (viability at 94%) (p < 0.05) (Figure 2A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11015054	Subsequent KEGG pathway enrichment analysis showed it could significantly affect NET formation and release.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Subsequent", "KEGG", "pathway", "enrichment", "analysis", "showed", "i...
PMC11468365	Equation (20) shows the calculation for .20[12pt] $$_=_(R(_),(R(_)),$$=CCp(Rya,Ryp,where and represent the rank values of the actual and predicted scores, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11768927	Le Boeuf et al. further investigated the combination of vaccinia virus and VSV, and found that vaccinia enhanced VSV replication and antitumor activity, while VSV facilitated the spread of vaccinia virus within tumor cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Image: Summary/Conclusion: Taken together, our findings provide a much clearer understanding of resistance to VEN and provide impetus for improved VEN-based clinical management of CLL patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9027909	The main reason for choosing this isolate was to investigate the effects of a clinically isolated Blastocystis sp., because it is documented that continuous cultivation of eukaryotes in axenic conditions may affect their physiological and pathogenic features .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5811757	A2780/ADR cells were transfected with all three vectors carrying the sgRNAs/Cas9, simultaneously (Figure 2), scrambled transfected cells were kept as control.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ],...
PMC6771295	Image J was used for quantification.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Image", "J", "was", "used", "for", "quantification", "." ] } ]
PMC11751675	Glyceraldehyde-3-phosphate and pyruvic acid are converted to isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (5 : 1 ratio) through 7 enzymes in the MEP pathway.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8839885	Cell lines: Human platinum-sensitive and resistant OC cell lines A2780 and A2780CisR, respectively (obtained from the American Type Culture Collection [ATCC], Manassas, VA, USA), were cultured in RPMI 1640 complete medium supplemented with 10% (w/v) fetal bovine serum (Biological Industries, Beit-Haemek, Israel), 1% (w/v) L-glutamine, 100 units/mL penicillin, and 0.1 mg/mL streptomycin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC10874773	This type of compounds from a γ-lactone ring between C4-C11, and some compounds also exhibit a keto-enol equilibrium between C7-C14 (Fig. 8).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11391695	To generate stable expression cell lines for the HCC transplant tumor model, cells were transfected with pcDNA/PEI/NPs@M and its negative control (nc/PEI/NPs@M).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC9429973	Methods: Patient-derived epithelial cells were reprogrammed with the EBV-derived oriP/EBNA-1 system carrying transcription factors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "Patient-derived", "epithelial", "cells", "were", ...
PMC3274243	RSF cells were seeded into six Oncoprobe wells at a density of 5 × 10 cells well in a 300 μL volume, the remaining two wells received medium alone.	[ { "tags": [ "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11658074	The rapid internalization of AT-EVs by cells is facilitated by CD151 on the AT-EV surface.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "rapid", "internalization", "of", "AT-EVs", "by", "ce...
PMC8777939	Spheroid cultures of the ovarian cancer cell lines were cultured in neurobasal medium (Gibco) containing 1X B27 (Gibco), 10 ng/m basic fibroblast growth factor (Peprotech, Rocky Hill, NJ, USA), 20 ng/mL EGF (Peprotech), HEPES (Gibco), Glutamax (Gibco), and penicillin/streptomycin (Welgen).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC6684588	Data are means ± SEM (n = 5 for vehicle-treated wild-type; n = 9–10 for other groups). (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "me...
PMC9429973	Summary/Conclusion: It was found that markers such as LDH, β2-mg, TK, TPA, ZAP70 and NOTCH1 gene mutation have certain prognostic significance, which was confirmed by comparing their levels in patients with and without CLL progression after 3 years of observation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Summary/Conclusion: In humanized SCD mice exposed to H/R stress to mimic acute VOCs, epeleuton acts as a multimodal agent targeting red cells, hemolysis, inflammatory response, and vascular dysfunction.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5330095	Viral hepatitis B (HBV) and hepatitis C (HCV) pose a major health problem globally and if untreated, both viruses lead to severe liver damage resulting in liver cirrhosis and cancer.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9436459	0.7 μg/mL (5-FU)Bel-7402n.a.	[ { "tags": [ "O", "O", "O", "O" ], "tokens": [ "0.7", "μg/mL", "(5-FU)Bel-7402n.a", "." ] } ]
PMC10571053	Trypsinized OVCAR8 or NCI/ADR-RES cells were incubated with 2% bovine serum albumin/PBS containing phycoerythrin-labeled UIC-2 antibody to isotype control antibody for 20 min, after which cells were washed in PBS and read on a flow cytometer.	[ { "tags": [ "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC11754432	The association of ALOX15B and cytokine production appears to be cell-specific.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "association", "of", "ALOX15B", "and", "cytokine", "production", "appears", "to", ...
PMC10079526	PonceauS staining was used as control.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "PonceauS", "staining", "was", "used", "as", "control", "." ] } ]
PMC9874064	Data are expressed in mean ± SD from n independent experiments (n = 3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "expressed", "in", "mean", "±", "...
PMC11787651	TGF-β, transforming growth factor beta.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "TGF-β", ",", "transforming", "growth", "factor", "beta", "." ] } ]
PMC10674574	Additionally, five and four were set for the zero-permeability and efflux substrate groups, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Additionally", ",", "five", "and", "four", "were", ...
PMC11594074	Correlation analyses were carried out between the molecular weight and logP of the ligands and the predicted binding affinities.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Correlation", "analyses", "were", ...
PMC11012313	Taken together, these data confirm that LMP2A increases HIF-1α levels in the presence of the entire virus and other EBV latency proteins.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Taken",...
PMC11687167	PACMAN1.	[ { "tags": [ "O", "O" ], "tokens": [ "PACMAN1", "." ] } ]
PMC11106977	In recent years, the pathophysiological roles of these post-translational modifications (PTMs) have attracted a great deal of attention .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "recent", "y...
PMC10831439	Isolated iNKT cells were activated with α-GalCer-loaded autologous feeder cells (1:2 iNKT cell to feeder cells ratio), 200 I.U./mL recombinant human interleukin 2 (rhIL-2, Novartis, Basel, Switzerland) and 200 ng/mL α-GalCer in CAR medium containing 45% EHAA (Clicks) medium (Irvine Scientific, Santa Ana, USA), 45% RPMI 1640 (ThermoFisher Scientific, Waltham, USA), 2 mM L-glutamine (Lonza, Basel, Switzerland) and 10% FBS (fetal bovine serum, Sigma-Aldrich).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11590870	As mentioned, 500 µg/mL of MOP showed an antioxidative activity of 35.10 ± 1.77% in Caco-2.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O" ], "tokens": [ "As", "mentioned", ",", "500", ...
PMC9429973	ACY-1215 exposure on CD34-cells driven in vitro towards the erythroid lineage led to a decreased cell count, an increased apoptotic rate and a delayed erythroid differentiation with accumulation of weakly hemoglobinized immature erythroblasts.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	GLS1 expression was increased in refractory anemia with excess of blasts (RAEB)-2 cells compared to normal control cells (GSE19429).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "GLS1", "expres...
PMC11653168	Each experiment was performed in duplicate, at least three times independently.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Each", "experiment", "was", "performed", "in", "duplicate", ",", "at", "least", ...
PMC8633974	Flow cytometry assay results for % GFP-positive cells are shown in “e”.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Flow", "cytometry", "assay", "results", "for", "%", "GFP-positive", ...
PMC9920575	It should be noted that the inhibition potential of S. chinantlense is similar to that of cisplatin, with a difference of 1.1 μg/mL between their IC50 values, and S. chinantlense has the advantage of being a natural extract that is considered less toxic to normal cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11185260	Most ATRTs contain less than ten coding mutations, and large chromosome gain or loss is uncommon.6–8 The only recurring molecular abnormality that characterizes ATRT is the inactivation of the SMARCB1 gene, which is observed in nearly 98% of ATRT patients.9 SMARCB1 encodes a core subunit of the SWI/SNF chromatin remodeling complex that contributes to developmental processes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9776316

A similar trend was also observed in the colony formation; the combination of XRCC4 knockdown and cisplatin treatment strongly abolished the colony formation potential in the cisplatin-resistant ovarian cancer cell lines, supporting the role of XRCC4 in the regulation of cisplatin sensitivity (Figure 2f,g).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11599565

Panel A: Neuromelanin-expressing cells in SKOV3 wildtype and its cisplatin resistant subline.

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PMC11703992

In GCA samples, CD4+ Memory T cells showed high similarity to them in the old samples.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "GCA", "samples", ",", "CD4", ...

PMC10237474

For glycosylated proteins, 5 μg of protein was deglycosylated using either non-reduced or reduced rapid PNGase F in a total reaction volume of 20 μL at 50°C for 20–30 min.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC6222635

The 4% paraformaldehyde was removed, and the cells were washed three times with PBS.

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PMC11760643

More recently, our group has used this mAb to demonstrate the role of donor (human) P2X7 in promoting graft‐versus‐host disease (GVHD) in humanised mice .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11767725

A flowchart of the complex interactions between AGE-RAGE pathway and the skin is illustrated in Figure 2.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "flowchart", "of", "the", "complex", "i...

PMC11612626

RPMI-8226, ARH-77, and U266 cells were incubated with each compound at the indicated time and concentration.

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PMC10243817

Although TGF-βR3 function has been studied in myoblasts (28, 29), its function in airway epithelial cells has yet to be determined.

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PMC8711270

HEK293E and HEK293-6E is widely used in TGE as the use of plasmids with Epstein-Barr virus oriP significantly improves TGE (Pham et al., 2006).

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PMC11222184

Interestingly, XL-888 treatment led to an upregulation in the expression of hypoxia signaling-related genes HMOX1 and SLC2A1, whereas Debio0932 treatment resulted in a downregulation of CA9 and HMOX1 expression.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11655498

In contrast, its absence impairs reactivation triggered by inducers (Liu and Cohen, 2016).

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PMC11759751

P < 0.05; **P < 0.01; ***P < 0.001 Low-dose chidamide did not affect the proliferation, apoptosis and anti-tumor ability of prepared CD19 CAR T cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

One pt required VEN dose reduction due to cytopenias.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "One", "pt", "required", "VEN", "dose", "reduction", "due", "to", "cytopenias", "." ] } ]

PMC11055323

b Representative images of SS18-EGFP and SS18-SSX1-EGFP fusion protein overexpressed via lentiviral infection in BJ fibroblasts.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "b", "Representative", "images", "of", "SS18-EGFP", "an...

PMC9429973

The disease burden and response to therapy rely on a dynamic system: the hematopoietic stem cells (HSC) receptor characteristics (baseline degree of immune dysfunction, bone marrow microenvironment, bone marrow and gut microbiomes); the HSC donor characteristics and graft relative cellular composition.

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PMC9429973

Given the high rate of progression of SCR, screening of SCR remains important, but differentiated strategies for screening and follow-up of SCR could be considered for low-risk or high-risk patients.

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PMC9429973

Percent without high school degree (HSD) reflects the education level within the pt’s zip code, which was stratified into 4 quartiles.

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PMC7723249

Previous studies have suggested that the disease progression of viral hemorrhagic fevers could be due to a cytokine storm and high viremia .

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PMC7602170

The incidence rate was 10 to 15 per million per year.

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PMC11087301

Another investigation of CTCs from breast cancer revealed that fluid shear stress promotes EMT in the epithelial CTCs and maintains mesenchymal CTCs by mechanistically activating JNK signaling.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11676169

KU70 acetylation levels were further increased under DNA-damaging conditions (Supplementary Figure S4) .

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PMC9454852

Calpain activity was determined in the absence or presence of 100 μM BOLD-100, and in the presence of a calpain inhibitor (PD150606).

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PMC11457557

According to a recent theory, TGF1 may have an essential role in the early stages of DKD development, and several miRNAs and long non-coding RNAs (lncRNAs) control the critical molecules in the TGF1 pathway.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC6222635

The DPFs F1 and F3 exhibited significant anti-proliferation activity in a dose-dependent manner.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "DPFs", "F1", "and", "F3", "exhibited", "significant", "anti-prolifer...

PMC9429973

All but ELEVATE -TN study included patients previously treated with CLL.

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PMC11686380

Our findings, along with previous reports, contribute to uncover the pathophysiology of GAP43-associated neurodevelopmental diseases and highlight the crucial roles of GAP43 in brain development, particularly in dendritic arborization, dendritogenesis, and interhemispheric axon extension.

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PMC11469524

A previous study on Hela cells determined that the crosstalk is conferred by direct binding of p38 to ERK , as it demonstrated direct binding and no change in MEK phosphorylation.

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PMC9429973

The effects of different concentrations of As2O3 on the expression of apoptosis related proteins Bcl-2, Bax, Caspas-3 and PARP were detected by ELISA.

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PMC11699465

Colony formation assay to show the cell proliferation ability in 4T1 cells with TMEM199 knock down. (

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PMC8010066

The viability of P. aeruginosa was measured as log10 (CFU/well) in the co-culture with S. aureus.

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PMC11462929

A black arrow indicates an interaction between MYC gene and N‐ME regions.

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PMC11679033

Mycotoxins persist in these products’ post-processing, posing health risks via multiple exposure routes.

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PMC9780037

Storage at room temperature could be extended to 5 months.

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PMC11676169

KU70 acetylation has been shown to impair c-NHEJ activity by modifying the KU70 lysine residues needed for binding dsDNA ends .

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PMC5716223

Hsp27 and αB-Cry are key components of the myofibril structure, with a prominent role in skeletal muscle physio-pathology and in exercise-related adaptation to damaging contraction .

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PMC11422150

In assessing the systemic inflammatory response, hAMSC treatment reduced monocytic bone marrow-derived suppressor cells (M-MDSCs) and Ly6C-positive inflammatory macrophages in the bone marrow by flow cytometry and serum NO levels by ELISA assay.

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PMC4360730

Once determined, the required relationships are reported to the relevant ontologies using their designated format of issue submission.

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PMC11297139

Through genome-wide chromatin structure and transcription profiling, we identify that the ARID1A condensate localizes to EWS/FLI1 target enhancers and induces long-range chromatin architectural changes by forming functional chromatin remodeling hubs at oncogenic target genes.

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PMC10890307

After incubation, the cells were harvested by non-enzymatic treatment (EDTA-MOPS).

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PMC11765988

A linkage to DRB1 is a shared feature of sarcoidosis and lymphoma.

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PMC11301927

Most were male (71%), had clear cell RCC (88%) and had intermediate/poor risk disease (79%).

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PMC11047729

The higher the concentration of CAUE, the better inhibiting properties it displayed toward hTERT.

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PMC11297139

Scale bar: 2 μm.

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PMC9429973

Patients in this study received an 8-week period of treatment.

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PMC10362265

The inconsistency between RG and SASA is likely to be resulted from the fact that the shape of the heterodimers and possibly the monomers are not ideally globular (Fig. 1), rendering RG measurements less informative about the shape than SASA measurements .

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PMC11617590

Mia PaCa‐2 cells were seeded at 4 × 10 cells/3 mL/well and were treated for 24 h with sulforaphane (SFN) at concentrations of 0, 25, and 100 μM. Protein expression of cMyc and β‐Actin were measured using Western blot analysis.

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PMC9429973

Statistical analyses were performed using codes suggested by the National Institute for Health and Care Excellence.

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PMC11721295

A P value associated with this statistic was also computed using an adaptive multilevel split Monte Carlo simulation.

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PMC8164677

Binding Energy (kcal/mol) and Post-Dock Analysis of the Best Pose of Wedelolactone with Hepatocyte Growth Factor Receptor (cMET), Checkpoint Kinase 1 (Chk1), Ecto-5′-Nucleotidase (CD73), Mammalian Target of Rapamycin (mTOR1), Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2), Hypoxia-Inducible Factor 2-Alpha (HIF2α), Heat Shock Protein 60 (HSP60), Insulin Like Growth Factor (IGF1), P300/CBP-Associated Factor (PCAF), Bromodomain Protein 1 (Brd1) and Acetyl Transferase Tip (at Tip60) Abbreviations: ALA, alanine; ASN, asparagine; ASP, aspartic acid; ARG, arginine; CYS, cysteine; GLU, glutamic acid; GLY, glycine; GLN, glutamine; HIS, histidine; LYS, lysine; PHE, phenylalanine; SER, serine; THR, threonine; TRP, tryptophan; TYR, tyrosine; VAL, valine.

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PMC11088135

Similar results were observed in A172 cells (Supplementary Fig. 1).

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PMC11536589

However, PKF-118-310 effectively induced cell death in AsPC1-MR cells and KPC210-MR cells (Fig. 6C).

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PMC5034105

The findings in our study may have important clinical and epidemiological implications for this rapidly expanding viral epidemic.

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PMC11448304

Then, to validate these results, we used another lung adenocarcinoma cell line, H1299.

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PMC11552389

On day 24 post-transplantation, tumor samples were taken and weighed. (

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PMC7504302

The primary etiological factor of MPM is the past occupational and environmental exposure to the exogenous factor asbestos, which accounts for ~80% of the diagnosed cases .

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PMC9516401

These cases should be further investigated in the future.

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PMC11194678

Essential for mRNA transport and localization, STAU1 was found to organize RNA-containing granules destined for dendritic spines in mature hippocampal neurons (Mitsumori et al., 2017; Vessey et al., 2008).

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PMC11047729

IFN-α has also been shown to amplify graft-versus-leukemia (GVL) response in the case of allogeneic hematopoietic cell transplantation (HCT) for high-risk AML, which prevents leukemia relapse .

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PMC10914904

Finally, m5C methylation has been shown to improve the stability and proper folding of noncoding RNAs (ncRNAs).

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PMC11536589

AsPC1-MR cells or KPC210-MR cells were infected with the various lentiviral vectors.

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PMC11476837

Doxorubicin at 100 nM significantly reduced the viability of HL-60 cells (viability at 68%) (p < 0.001) and slightly reduced the viability of HL-60/DR cells (viability at 94%) (p < 0.05) (Figure 2A).

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PMC11015054

Subsequent KEGG pathway enrichment analysis showed it could significantly affect NET formation and release.

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PMC11468365

Equation (20) shows the calculation for .20[12pt] $$_=_(R(_),(R(_)),$$=CCp(Rya,Ryp,where and represent the rank values of the actual and predicted scores, respectively.

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PMC11768927

Le Boeuf et al. further investigated the combination of vaccinia virus and VSV, and found that vaccinia enhanced VSV replication and antitumor activity, while VSV facilitated the spread of vaccinia virus within tumor cells.

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PMC9429973

Image: Summary/Conclusion: Taken together, our findings provide a much clearer understanding of resistance to VEN and provide impetus for improved VEN-based clinical management of CLL patients.

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PMC9027909

The main reason for choosing this isolate was to investigate the effects of a clinically isolated Blastocystis sp., because it is documented that continuous cultivation of eukaryotes in axenic conditions may affect their physiological and pathogenic features .

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PMC5811757

A2780/ADR cells were transfected with all three vectors carrying the sgRNAs/Cas9, simultaneously (Figure 2), scrambled transfected cells were kept as control.

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PMC6771295

Image J was used for quantification.

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PMC11751675

Glyceraldehyde-3-phosphate and pyruvic acid are converted to isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (5 : 1 ratio) through 7 enzymes in the MEP pathway.

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PMC8839885

Cell lines: Human platinum-sensitive and resistant OC cell lines A2780 and A2780CisR, respectively (obtained from the American Type Culture Collection [ATCC], Manassas, VA, USA), were cultured in RPMI 1640 complete medium supplemented with 10% (w/v) fetal bovine serum (Biological Industries, Beit-Haemek, Israel), 1% (w/v) L-glutamine, 100 units/mL penicillin, and 0.1 mg/mL streptomycin.

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PMC10874773

This type of compounds from a γ-lactone ring between C4-C11, and some compounds also exhibit a keto-enol equilibrium between C7-C14 (Fig. 8).

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PMC11391695

To generate stable expression cell lines for the HCC transplant tumor model, cells were transfected with pcDNA/PEI/NPs@M and its negative control (nc/PEI/NPs@M).

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PMC9429973

Methods: Patient-derived epithelial cells were reprogrammed with the EBV-derived oriP/EBNA-1 system carrying transcription factors.

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PMC3274243

RSF cells were seeded into six Oncoprobe wells at a density of 5 × 10 cells well in a 300 μL volume, the remaining two wells received medium alone.

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PMC11658074

The rapid internalization of AT-EVs by cells is facilitated by CD151 on the AT-EV surface.

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PMC8777939

Spheroid cultures of the ovarian cancer cell lines were cultured in neurobasal medium (Gibco) containing 1X B27 (Gibco), 10 ng/m basic fibroblast growth factor (Peprotech, Rocky Hill, NJ, USA), 20 ng/mL EGF (Peprotech), HEPES (Gibco), Glutamax (Gibco), and penicillin/streptomycin (Welgen).

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PMC6684588

Data are means ± SEM (n = 5 for vehicle-treated wild-type; n = 9–10 for other groups). (

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PMC9429973

Summary/Conclusion: It was found that markers such as LDH, β2-mg, TK, TPA, ZAP70 and NOTCH1 gene mutation have certain prognostic significance, which was confirmed by comparing their levels in patients with and without CLL progression after 3 years of observation.

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PMC9429973

Summary/Conclusion: In humanized SCD mice exposed to H/R stress to mimic acute VOCs, epeleuton acts as a multimodal agent targeting red cells, hemolysis, inflammatory response, and vascular dysfunction.

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PMC5330095

Viral hepatitis B (HBV) and hepatitis C (HCV) pose a major health problem globally and if untreated, both viruses lead to severe liver damage resulting in liver cirrhosis and cancer.

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PMC9436459

0.7 μg/mL (5-FU)Bel-7402n.a.

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PMC10571053

Trypsinized OVCAR8 or NCI/ADR-RES cells were incubated with 2% bovine serum albumin/PBS containing phycoerythrin-labeled UIC-2 antibody to isotype control antibody for 20 min, after which cells were washed in PBS and read on a flow cytometer.

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PMC11754432

The association of ALOX15B and cytokine production appears to be cell-specific.

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PMC10079526

PonceauS staining was used as control.

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PMC9874064

Data are expressed in mean ± SD from n independent experiments (n = 3).

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PMC11787651

TGF-β, transforming growth factor beta.

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PMC10674574

Additionally, five and four were set for the zero-permeability and efflux substrate groups, respectively.

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PMC11594074

Correlation analyses were carried out between the molecular weight and logP of the ligands and the predicted binding affinities.

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PMC11012313

Taken together, these data confirm that LMP2A increases HIF-1α levels in the presence of the entire virus and other EBV latency proteins.

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PMC11687167

PACMAN1.

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PMC11106977

In recent years, the pathophysiological roles of these post-translational modifications (PTMs) have attracted a great deal of attention .

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PMC10831439

Isolated iNKT cells were activated with α-GalCer-loaded autologous feeder cells (1:2 iNKT cell to feeder cells ratio), 200 I.U./mL recombinant human interleukin 2 (rhIL-2, Novartis, Basel, Switzerland) and 200 ng/mL α-GalCer in CAR medium containing 45% EHAA (Clicks) medium (Irvine Scientific, Santa Ana, USA), 45% RPMI 1640 (ThermoFisher Scientific, Waltham, USA), 2 mM L-glutamine (Lonza, Basel, Switzerland) and 10% FBS (fetal bovine serum, Sigma-Aldrich).

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PMC11590870

As mentioned, 500 µg/mL of MOP showed an antioxidative activity of 35.10 ± 1.77% in Caco-2.

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PMC9429973

ACY-1215 exposure on CD34-cells driven in vitro towards the erythroid lineage led to a decreased cell count, an increased apoptotic rate and a delayed erythroid differentiation with accumulation of weakly hemoglobinized immature erythroblasts.

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PMC9429973

GLS1 expression was increased in refractory anemia with excess of blasts (RAEB)-2 cells compared to normal control cells (GSE19429).

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PMC11653168

Each experiment was performed in duplicate, at least three times independently.

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PMC8633974

Flow cytometry assay results for % GFP-positive cells are shown in “e”.

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PMC9920575

It should be noted that the inhibition potential of S. chinantlense is similar to that of cisplatin, with a difference of 1.1 μg/mL between their IC50 values, and S. chinantlense has the advantage of being a natural extract that is considered less toxic to normal cells .

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PMC11185260

Most ATRTs contain less than ten coding mutations, and large chromosome gain or loss is uncommon.6–8 The only recurring molecular abnormality that characterizes ATRT is the inactivation of the SMARCB1 gene, which is observed in nearly 98% of ATRT patients.9 SMARCB1 encodes a core subunit of the SWI/SNF chromatin remodeling complex that contributes to developmental processes.

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