OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC9429973	The rate of splicing factors alterations in CALR mutants was significantly lower compared with JAK2 or MPL mutants (3.9% vs 22.3% vs 35.7%, p<0.001).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11792888	In MRC-5 cells, the proportion of cells in the S phase increased from 13.6% ± 2.22% to 23.8% ± 2.32% (1.42 mg/mL venom concentration), with a concomitant decrease of cells in the G0/G1 phase (Figure 2 A ).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11794568	Calcium, as an important second messenger, is involved in a variety of intracellular signaling pathways, including processes such as cell proliferation and apoptosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11173119	In this study, we used the technology of reprogramming PBMCs into a pluripotent state to obtain patient-specific iPSCs from a patient with FMF associated with the pathogenic mutation p.M694V (according to the databases Infevers, OMIM, ClinVar, Ensembl, etc.)	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11783017	In addition, we used western blotting to detect the differences in IL-11Rα expression in 143B cells after treatment with Lipo and Lipo-IL11.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11471176	Note: X-axis units are as follows: 100 on the X-axis scale = 100 mM for carnosine, 10 nM of standard kit inhibitor, and 0.105 % of DMSO.Fig.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11741906	These findings make resistance-associated miRNAs a promising target for reversing resistance and increasing treatment efficiency in ovarian cancer cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "findings", "make", "resi...
PMC11791264	Each bar represents the mean ± SD (n = 3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Each", "bar", "represents", "the", "mean", "±", "SD", "(", "n", "=", ...
PMC10502403	Calculations were performed using SPSS Statistics version 26 (IBM Japan, Ltd., Tokyo, Japan).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Calculations", "were", "performed", "using",...
PMC6642070	Data are shown as mean ± SD, P < .05, *P < .01 (one-way ANOVA, Tukey's test).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11536589	The KPC cells that were not treated with MRTX1133 named untreated KPC cells in our study, including cells utilized as control and cells treated with DMSO.	[ { "tags": [ "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...
PMC11127909	The supernatant was collected and centrifuged at 11,000 × g for 10 min at 4 °C, and the precipitate (mitochondrial fraction) was collected for WB or mitochondrial swelling assay analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	A. Pêgo, I. Lima, G. Martins, M. Vujic, A. Nai, L. Silvestri, R. Gozzelino Inflammation and neurodegeneration, CEDOC-NMS/UNL, Lisboa, Portugal; Universidade Técnica do Atlântico, São Vicente, Cape Verde; Hormonal regulation of iron homeostasis, Institute of Comparative Molecular Endocrinology, Ulm, Germany; Regulation of iron metabolism; San Raffaele Scientific Institute, Milan, Italy Background: Severe malarial anemia (SMA) is a complication developed during Plasmodium infection.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Febrile neutropenia was defined as a single reading of oral temperature of ≥38 °C on two or more occasions in 12 h in the presence of absolute neutrophil count of less than 1000cells/mm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11612794	Immunoprecipitated samples were subjected to immunoblot analyses using anti-CENP-T, anti-FLAG, and anti-Dsn1 antibodies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Immunoprecipitated", "samples", "were", "subjected", "to", "immun...
PMC11680982	In addition, neratinib considerably reduced HER2 mRNA expression, according to the above results.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ",", "neratinib", "considerably", "reduced", ...
PMC11786767	Representative images of 4 types of Ctrl and RO-3306-treated cells are shown.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Representative", "images", "of", "4", "types", "of", "Ctrl", "and", "RO-3306-tre...
PMC9250505	C pBAD/BAD levels in EOC cell lines: western blot analysis was used to assess the levels of pBADS75 and pBADS99 and BAD expression in EOC cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11478724	After incubation, the formazan crystals were dissolved and the color intensity was measured with an ELISA plate reader at 570 nm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "inc...
PMC11470381	Resuspend cells in RPMI medium without phenol red for imaging.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Resuspend", "cells", "in", "RPMI", "medium", "without", "phenol", "red", "for", "imaging", ...
PMC9429973	Aims: To explore whether patients with naïve SAA could benefit from continuous use of E-PAG beyond 6 months and when E-PAG should be withdrawn in patients with no response.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11088135	It has been reported that lncRNA FOXD2-AS1 regulates glioma progression through the miR-31/CDK1 axis .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "has", "been", "reported", "that", "lncRNA", "FOXD2-AS1", "...
PMC11754094	Collectively, our findings support that M4344, ART558, or other drugs that reduce end resection or TMEJ pathways can be co-effectors for CRISPR-Cas9-mediated genetic engineering in therapeutic applications to mitigate unintended large deletions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11718031	All the other combinations followed a similar trend and remained below 10 mM. Notably, BalanCD CHO Feed 4 resulted in an elevated ammonia accumulation in all tested basal media, probably due to the high glutamate content in this feed (Hong et al. 2010).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11334037	The IGF2-IGF1R signaling axis assumes critical significance in governing cell proliferation, differentiation, EMT, migration, drug resistance, and maintaining stemness in malignancies.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC8998437	The percentage (%) of the identity shared with the top germline genes was determined by applying the NCBI IGBLAST Tool (https://www.ncbi.nlm.nih.gov/igblast/, accessed on 1 January 2021).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10745221	We employed polyclonal antibodies raised against synthetic peptides containing SDMA and ADMA within glycine rich regions to mimic the common substrate sites recognized by PRMT1, -3, -5, -6, and -8 .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11551844	The synthesis of AuNPs using the aqueous extract from the marine sponge Acanthella elongate has been reported by Inbakandan et al. (2010).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC6835428	The extracellular domain contains a ligand-binding domain, a Sushi domain, an epidermal growth factor (EGF)-like domain, and two fibronectin type-III repeats.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC4270159	Media only [additional].	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Media", "only", "[", "additional", "]", "." ] } ]
PMC9429973	In recent years, the treatment of MM has shown great evolution.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "recent", "years", ",", "the", "treatment", "of", "MM", "has", "shown...
PMC11502962	Imatinib, the first-line system therapy, achieves an excellent disease control in 80% of patients (25).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Imatinib", ",", "the", ...
PMC11802929	As expected, cytotoxic cells showed maximal clonal expansion followed by effector memory (EM) cells (Supplementary Fig. 7b).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "expect...
PMC9684669	All data represent mean ± SEM of at least 3 replicates.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "data", "represent", "mean", "±", "SEM", "of", "at", "least", "3", "repli...
PMC11575040	These results suggest that metformin’s inhibition of A2058 cell growth is partially mediated through a LINC00094-regulated signaling pathway.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "results", "suggest", ...
PMC8140214	Chandrasekaran et al. used 30 and 50 mM D-glucose for 72 hr to show toxic effects of hyperglycemia on HepG2 cells (Chandrasekaran et al., 2010 ▶).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", ...
PMC11052306	Since the discovery of cisplatin in the 1960s, the search for metallo-drugs that are more efficient than platinum complexes with negligible side effects has attracted much interest.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10094712	Interestingly, the treatment of human glioblastoma cells with recombinant hSELENOM led to an increase in SELENOM mRNA expression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Interestingly", ",", "the", "trea...
PMC10955424	After 30 min, samples were centrifuged, and supernatants were tested for protein concentration using DC™ Protein Assay (#5,000,111, Bio Rad, USA) by determining absorbance at 630 nm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11707832	The extracellular secretion of lysosomal enzymes holds significant relevance in initiating and sustaining inflammatory responses .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "extracellular", "secretion", "of", "lysosomal", "enzymes",...
PMC9966931	Sea water and DMSO were used as negative controls.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Sea", "water", "and", "DMSO", "were", "used", "as", "negative", "controls", "." ] } ]
PMC7709199	The crystal structure of human DSCAMIg7–Ig9 contains one molecule in the asymmetric unit.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "crystal", "structure", "of", "human", "DSCAMIg7–Ig9", "contains", "o...
PMC11732635	A small number of children with EBV infection may develop chronic or recurrent contagious mononucleosis-like symptoms, the infection may develop into CAEBV, and a variety of life-threatening complications may emerge, such as hemophagocytic lymphohistiocytosis (HLH), interstitial pneumonia, peptic ulcer, lymphoma, intestinal pneumoniae, vasculitis, uveitis, liver failure, coronary aneurysms, and central nervous system involvement (2,3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11604015	This universal CAR-T cell product, derived from unrelated healthy donors, is resistant to GvHD and allo-rejection and could theoretically be used in all patients (Fig. 3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11098378	Since bacteria and viruses can encounter common host defenses, we hypothesized that some bacterial effectors may inhibit host factors that restrict arbovirus replication in lepidopteran cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5417661	Finally, the MI was determined from cell samples that were fixed and DNA stained at 24 and 48 h time points posttreatment and imaged using HC-fluorescent microscope enabling accurate identification of mitotic cells based on chromatin condensation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9712534	A small area of the nucleus (shown with a white arrow) was photobleached, and fluorescence images were captured at the indicated time points. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11721587	The distribution of total Fu and phosphorylated Fu in condensates (P100) and supernatant (S100) at different time points was analyzed by immunoblot after re-centrifugation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Median PFS in newly diagnosed primary EMD patients was comparable to reference MM patients (23.2 months [95% CI: 21.2–26.2] vs. 23.3 months [95% CI: 22.5–24.8], p=0.800).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5854676	Figure 5Raman spectroscopy from (a) MgO (b) MgO + PEG.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Figure", "5Raman", "spectroscopy", "from", "(", "a", ")", "MgO",...
PMC11670407	Interestingly, our results revealed that GPX4 overexpression significantly reversed the proapoptotic effects of OTULIN knockdown, whereas OTULIN overexpression did not reverse the proapoptotic effects of GPX4 knockdown.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11354239	Further sample quantity, purity, and integrity assessment with the Agilent TapeStation system; RNA-seq library preparation with TruSeq Stranded mRNA Library kit (Illumina); library normalization; sequencing with HiSeq X Ten platform in a PE 2×150 bp format, with 10 million reads; and bioinformatics analysis (mapping, alignment, and differential expression analysis through Illumina’s Basespace software; https://basespace.illumina.com/, accessed on 8 February 2022) were commercially provided by Omega Bioservices company.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11740207	Assuming an average cell size of 15 µm for EpibCs during the G1 phase, the deploidization of AD allows 2_3 hypothetical VSELSCs to form in the G1 phase.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11098378	For example, in Lymantria dispar (spongy moth)-derived LD652 cells, VSV and SINV undergo abortive infections post-entry after limited gene expression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9895440	The supernatant of the 4:1 E:T ratio co-culture was used to measure IFNγ by ELISA (BD).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "supernatant", "of", ...
PMC8623816	Subsequently, computational analysis was performed to determine the type and number of alternative splicing (AS) events in strains D122 and D122-P. The results showed that five common types of AS events could be examined, including exon skipping, intron retention, alternative 5′ss splice or alternative 3′ss splice, alternative transcription start site (TSS) and alternative transcription terminal site (TTS) (Table 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9878562	We applied an algorithm using mobility values to generate plots that distinguish four populations according to their migratory behavior.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "We", "applied", "an", "algorithm"...
PMC10547921	Therefore, in the next generation of ADCs, it is necessary to develop structurally novel high-efficiency payloads (e.g., NAMPT inhibitors with simple structure, high activity, and special mechanism of action) with multiple mechanisms of action, higher efficacy, and fewer side effects by screening natural product libraries, chemical synthesis, and direct derivatization of natural products to improve the activity and its tolerance.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11285179	The relationship between expression levels of CEBPB and CCL28, RXRα, and ANNGPT1 were calculated online, as well as the predictive value of CEBPB for the survival of lung adenocarcinoma patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10988555	Some cobalt complexes can also present an antimetastatic behavior, and to evaluate this, a cell migration assay was used.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Some", "cobalt", ...
PMC11643491	Two film-stretching methods were tested for 0.8–2.4 μm polystyrene (PS) particles: one based on solubility in organic solvents and the other on heat-induced softening.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10530622	However, these are complex and not widely available, often requiring combinations of chromatographic and mass spectrometry techniques .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "these", "are", ...
PMC9583612	Future work will focus on emissions quantification using CEMS data.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Future", "work", "will", "focus", "on", "emissions", "quantification", "using", "CEMS", "data", ...
PMC11721096	The control cells transfected with empty vector exhibited no ability to catalyze L-DOPA.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "control", "cells", "transfected", "with", "empty", "vector", "exhibi...
PMC6835428	Unfortunately, no control siRNA was used, and thus the real specificity of the siRNA remains undetermined.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Unfortunately", ",", "no", "control", ...
PMC9429973	Methods: This is a retrospective multicentre analysis from the Transplant Complications Working Party (TCWP) of the EBMT using the data of the GoCART coalition.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10291556	Diclofenac, sodium -acetate (DCF, Figure 1) is an NSAID frequently used to treat pain; it is cost-effective and available as a generic drug.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Thirty co-morbidities were assessed using Elixhauser scoring.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Thirty", "co-morbidities", "were", "assessed", "using", "Elixhauser", "scoring", "." ] } ]
PMC11697703	Here, we show that the miR-193b∼365 microcluster: (1) is differentially expressed by developing corticospinal vs. callosal projection neurons, (2) is downstream of the selector gene Fezf2, (3) represses the callosal projection neuron-enriched signaling protein mitogen-activated protein kinase 8 (MAPK8, also known as JNK1), and (4) differentially controls dendritic morphology in deep-layer and superficial-layer neurons.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11770199	F4/80 expression in immune cells. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "F4/80", "expression", "in", "immune", "cells", ".", "(" ] } ]
PMC11772449	This conclusion suggests that in the autophagy regulatory network, the regulatory functions of p38α and p38γ may be different, which is also one of the innovations of this study.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9917080	The zeta potential was measured using Malvern Zetasizer Ultra Red Label 10.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "zeta", "potential", "was", "measured", "using", "Malvern", "Zetasizer", "...
PMC11790971	While in passage 1 and passage 2, cell line B exhibited unique morphological characteristics, including larger cell size and higher FAD and NAD(P)H intensities compared to other cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11665555	To identify key TFs, we performed a master regulator analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "identify", "key", "TFs", ",", "we", "performed", "a", "master", "regulator", ...
PMC11543853	In some cases, the tips of the membrane cones were attached to actin filaments that may serve as scaffolds for putative complexes, which bind to and pull on the vesicle membranes (Supplementary Fig. 1c).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC3931643	All three cell lines had detectable 4EBP2 mRNA expression (Fig. S3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "All", "three", "cell", "lines", "had", "detectable", "4EBP2", "mRNA", ...
PMC10170482	We summarized all chemicals, fluorescent probes, antibodies, and TaqMan probes used in this study in Tables S1–S4 (Supporting Information), including dilutions, manufacturers’ names, and catalogue numbers.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Interestingly, we find the cohort who attended after 2007 got obvious longer PFS than those who received treatment in 2000-2006(20.6 vs 10.0 months, P=0.017), which showed a similar result in OS (31.6 vs 16.0 months, P=0.034).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10560648	In short, immediately after capture, the tentacles were manually separated from the specimens and placed directly into small glass containers filled with seawater.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11564322	Indeed, previous studies revealed that EDPs increase the proliferation of lymphocytes; however, Péterszegi et al. and Szychowski et al. have also shown that κ-elastin can stimulate the proliferation or death of lymphocytes in a concentration-dependent manner as well as the amount of FBS used in the experiments [23–25].	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11394730	Piperine has a diverse mechanism of action, which gives it two unique properties as a chemopreventive agent: it can block the initiation of tumors and suppress the transformation of initiated cells into neoplastic cells .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Results: Two hundred and one consecutive MM patients, experiencing SPM ≥ 6 months since initiation of first line therapy were included in the analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC9429973	However, outcomes of pts after failure of both INO and Blina are not well-established, and effective treatment options for these pts are limited.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC4360730	We then selected three ontologies to cover these categories: Uber anatomy ontology (Uberon), Cell Ontology (CL) and Experimental Factor Ontology (EFO) (Figure 2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10530622	Furthermore, not only can the gut microbiota predispose, initiate, or promote the stone formation process, but the urinary microbiota has also been thought to have a role in this process, although the specific mechanisms are not completely understood .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Logistic problems at our centre with arranging central venous access, monitoring counts and timely admissions result in delays in administration.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Logistic", "problems", ...
PMC11700340	This approach has been demonstrated to be an effective method for developing novel anti-tumor medications , An example of a medication with a prospective anticancer effect is aspirin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11743975	Schematic diagram depicting the optogenetic-based mitochondrial aggregation system (Opto-MitoA) in cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Schematic", "diagram", "depicting", "the", "optogenetic-based", "mitochondrial", ...
PMC11319300	These four upstream AUG sequences located in MYEOV’s 5′ untranslated region (UTR) would prevent ribosomal binding via regulation of the ribosomal entry site (Barbosa et al., 2013), abrogating the translation of the MYEOV transcript (de Almeida et al., 2006).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11734514	A similar gene expression alteration was observed in STAT-3 (100bp) (Figure 2D and E).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "similar", "gene", "expression", "...
PMC11461833	The sequences of STXBP5 g1, STXBP5 g2 and STXBP5 g3 are listed in Table S1.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "sequences", "of", "STXBP5", "g1", ",", "S...
PMC11791264	The kinase STK4 phosphorylates LC3B at T50 to regulate the interaction of LC3B with FYCO1 and facilitate autophagosome–lysosome fusion (6, 21, 22).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11638255	A tissue microarray (TMA) was prepared using 20 Th-MYCN tumor samples (10 control, 10 TEPA-treated) in duplicate, cored at 1 mm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Interestingly, they preferentially rely on glycolysis rather than OXPHOS for their energy demands, as shown by the positive enrichment of glycolytic genes and by the 1.4-fold higher glucose uptake of th3 HSCs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11572213	The membranes visualized with an enhanced chemiluminescence substrate (SuperSignal, Thermo Fisher, USA) using the Azure C300 gel imaging system.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC10810426	Experiments were performed 3 times.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Experiments", "were", "performed", "3", "times", "." ] } ]
PMC9412887	Since most anticancer drugs are hydrophobic, if injected directly into the circulation, they not only have low bioavailability, but also have great toxicity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11726183	N-Benzylation of isatin was carried out via a reaction of isatin with benzyl bromide in the solvent acetonitrile in the presence of potassium carbonate and potassium iodide to yield 3.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11463018	1 3 8 ∼ 139 °C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "1", "3", "8", "∼", "139", "°", "C", "." ] } ]
PMC11052306	Unfortunately, the trifluoroacetic acid used for the deprotection of the amine at the core induced a partial cleavage of the imine bonds on the surface of the dendrons and precluded the use of these dendrons for grafting to GO.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

The rate of splicing factors alterations in CALR mutants was significantly lower compared with JAK2 or MPL mutants (3.9% vs 22.3% vs 35.7%, p<0.001).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11792888

In MRC-5 cells, the proportion of cells in the S phase increased from 13.6% ± 2.22% to 23.8% ± 2.32% (1.42 mg/mL venom concentration), with a concomitant decrease of cells in the G0/G1 phase (Figure 2 A ).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11794568

Calcium, as an important second messenger, is involved in a variety of intracellular signaling pathways, including processes such as cell proliferation and apoptosis.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC11173119

In this study, we used the technology of reprogramming PBMCs into a pluripotent state to obtain patient-specific iPSCs from a patient with FMF associated with the pathogenic mutation p.M694V (according to the databases Infevers, OMIM, ClinVar, Ensembl, etc.)

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11783017

In addition, we used western blotting to detect the differences in IL-11Rα expression in 143B cells after treatment with Lipo and Lipo-IL11.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...

PMC11471176

Note: X-axis units are as follows: 100 on the X-axis scale = 100 mM for carnosine, 10 nM of standard kit inhibitor, and 0.105 % of DMSO.Fig.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11741906

These findings make resistance-associated miRNAs a promising target for reversing resistance and increasing treatment efficiency in ovarian cancer cells.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "findings", "make", "resi...

PMC11791264

Each bar represents the mean ± SD (n = 3).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Each", "bar", "represents", "the", "mean", "±", "SD", "(", "n", "=", ...

PMC10502403

Calculations were performed using SPSS Statistics version 26 (IBM Japan, Ltd., Tokyo, Japan).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Calculations", "were", "performed", "using",...

PMC6642070

Data are shown as mean ± SD, *P < .05, **P < .01 (one-way ANOVA, Tukey's test).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC11536589

The KPC cells that were not treated with MRTX1133 named untreated KPC cells in our study, including cells utilized as control and cells treated with DMSO.

[ { "tags": [ "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "...

PMC11127909

The supernatant was collected and centrifuged at 11,000 × g for 10 min at 4 °C, and the precipitate (mitochondrial fraction) was collected for WB or mitochondrial swelling assay analysis.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

A. Pêgo, I. Lima, G. Martins, M. Vujic, A. Nai, L. Silvestri, R. Gozzelino Inflammation and neurodegeneration, CEDOC-NMS/UNL, Lisboa, Portugal; Universidade Técnica do Atlântico, São Vicente, Cape Verde; Hormonal regulation of iron homeostasis, Institute of Comparative Molecular Endocrinology, Ulm, Germany; Regulation of iron metabolism; San Raffaele Scientific Institute, Milan, Italy Background: Severe malarial anemia (SMA) is a complication developed during Plasmodium infection.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Febrile neutropenia was defined as a single reading of oral temperature of ≥38 °C on two or more occasions in 12 h in the presence of absolute neutrophil count of less than 1000cells/mm.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11612794

Immunoprecipitated samples were subjected to immunoblot analyses using anti-CENP-T, anti-FLAG, and anti-Dsn1 antibodies.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Immunoprecipitated", "samples", "were", "subjected", "to", "immun...

PMC11680982

In addition, neratinib considerably reduced HER2 mRNA expression, according to the above results.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "addition", ",", "neratinib", "considerably", "reduced", ...

PMC11786767

Representative images of 4 types of Ctrl and RO-3306-treated cells are shown.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Representative", "images", "of", "4", "types", "of", "Ctrl", "and", "RO-3306-tre...

PMC9250505

C pBAD/BAD levels in EOC cell lines: western blot analysis was used to assess the levels of pBADS75 and pBADS99 and BAD expression in EOC cell lines.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11478724

After incubation, the formazan crystals were dissolved and the color intensity was measured with an ELISA plate reader at 570 nm.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After", "inc...

PMC11470381

Resuspend cells in RPMI medium without phenol red for imaging.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Resuspend", "cells", "in", "RPMI", "medium", "without", "phenol", "red", "for", "imaging", ...

PMC9429973

Aims: To explore whether patients with naïve SAA could benefit from continuous use of E-PAG beyond 6 months and when E-PAG should be withdrawn in patients with no response.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11088135

It has been reported that lncRNA FOXD2-AS1 regulates glioma progression through the miR-31/CDK1 axis .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", "has", "been", "reported", "that", "lncRNA", "FOXD2-AS1", "...

PMC11754094

Collectively, our findings support that M4344, ART558, or other drugs that reduce end resection or TMEJ pathways can be co-effectors for CRISPR-Cas9-mediated genetic engineering in therapeutic applications to mitigate unintended large deletions.

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PMC11718031

All the other combinations followed a similar trend and remained below 10 mM. Notably, BalanCD CHO Feed 4 resulted in an elevated ammonia accumulation in all tested basal media, probably due to the high glutamate content in this feed (Hong et al. 2010).

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PMC11334037

The IGF2-IGF1R signaling axis assumes critical significance in governing cell proliferation, differentiation, EMT, migration, drug resistance, and maintaining stemness in malignancies.

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PMC8998437

The percentage (%) of the identity shared with the top germline genes was determined by applying the NCBI IGBLAST Tool (https://www.ncbi.nlm.nih.gov/igblast/, accessed on 1 January 2021).

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PMC10745221

We employed polyclonal antibodies raised against synthetic peptides containing SDMA and ADMA within glycine rich regions to mimic the common substrate sites recognized by PRMT1, -3, -5, -6, and -8 .

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PMC11551844

The synthesis of AuNPs using the aqueous extract from the marine sponge Acanthella elongate has been reported by Inbakandan et al. (2010).

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PMC6835428

The extracellular domain contains a ligand-binding domain, a Sushi domain, an epidermal growth factor (EGF)-like domain, and two fibronectin type-III repeats.

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PMC4270159

Media only [additional].

[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "Media", "only", "[", "additional", "]", "." ] } ]

PMC9429973

In recent years, the treatment of MM has shown great evolution.

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PMC11502962

Imatinib, the first-line system therapy, achieves an excellent disease control in 80% of patients (25).

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PMC11802929

As expected, cytotoxic cells showed maximal clonal expansion followed by effector memory (EM) cells (Supplementary Fig. 7b).

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PMC9684669

All data represent mean ± SEM of at least 3 replicates.

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PMC11575040

These results suggest that metformin’s inhibition of A2058 cell growth is partially mediated through a LINC00094-regulated signaling pathway.

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PMC8140214

Chandrasekaran et al. used 30 and 50 mM D-glucose for 72 hr to show toxic effects of hyperglycemia on HepG2 cells (Chandrasekaran et al., 2010 ▶).

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PMC11052306

Since the discovery of cisplatin in the 1960s, the search for metallo-drugs that are more efficient than platinum complexes with negligible side effects has attracted much interest.

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PMC10094712

Interestingly, the treatment of human glioblastoma cells with recombinant hSELENOM led to an increase in SELENOM mRNA expression.

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PMC10955424

After 30 min, samples were centrifuged, and supernatants were tested for protein concentration using DC™ Protein Assay (#5,000,111, Bio Rad, USA) by determining absorbance at 630 nm.

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PMC11707832

The extracellular secretion of lysosomal enzymes holds significant relevance in initiating and sustaining inflammatory responses .

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PMC9966931

Sea water and DMSO were used as negative controls.

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PMC7709199

The crystal structure of human DSCAMIg7–Ig9 contains one molecule in the asymmetric unit.

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PMC11732635

A small number of children with EBV infection may develop chronic or recurrent contagious mononucleosis-like symptoms, the infection may develop into CAEBV, and a variety of life-threatening complications may emerge, such as hemophagocytic lymphohistiocytosis (HLH), interstitial pneumonia, peptic ulcer, lymphoma, intestinal pneumoniae, vasculitis, uveitis, liver failure, coronary aneurysms, and central nervous system involvement (2,3).

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PMC11604015

This universal CAR-T cell product, derived from unrelated healthy donors, is resistant to GvHD and allo-rejection and could theoretically be used in all patients (Fig. 3).

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PMC11098378

Since bacteria and viruses can encounter common host defenses, we hypothesized that some bacterial effectors may inhibit host factors that restrict arbovirus replication in lepidopteran cells.

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PMC5417661

Finally, the MI was determined from cell samples that were fixed and DNA stained at 24 and 48 h time points posttreatment and imaged using HC-fluorescent microscope enabling accurate identification of mitotic cells based on chromatin condensation.

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PMC9712534

A small area of the nucleus (shown with a white arrow) was photobleached, and fluorescence images were captured at the indicated time points. (

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PMC11721587

The distribution of total Fu and phosphorylated Fu in condensates (P100) and supernatant (S100) at different time points was analyzed by immunoblot after re-centrifugation.

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PMC9429973

Median PFS in newly diagnosed primary EMD patients was comparable to reference MM patients (23.2 months [95% CI: 21.2–26.2] vs. 23.3 months [95% CI: 22.5–24.8], p=0.800).

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PMC5854676

Figure 5Raman spectroscopy from (a) MgO (b) MgO + PEG.

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PMC11670407

Interestingly, our results revealed that GPX4 overexpression significantly reversed the proapoptotic effects of OTULIN knockdown, whereas OTULIN overexpression did not reverse the proapoptotic effects of GPX4 knockdown.

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PMC11354239

Further sample quantity, purity, and integrity assessment with the Agilent TapeStation system; RNA-seq library preparation with TruSeq Stranded mRNA Library kit (Illumina); library normalization; sequencing with HiSeq X Ten platform in a PE 2×150 bp format, with 10 million reads; and bioinformatics analysis (mapping, alignment, and differential expression analysis through Illumina’s Basespace software; https://basespace.illumina.com/, accessed on 8 February 2022) were commercially provided by Omega Bioservices company.

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PMC11740207

Assuming an average cell size of 15 µm for EpibCs during the G1 phase, the deploidization of AD allows 2_3 hypothetical VSELSCs to form in the G1 phase.

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PMC11098378

For example, in Lymantria dispar (spongy moth)-derived LD652 cells, VSV and SINV undergo abortive infections post-entry after limited gene expression.

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PMC9895440

The supernatant of the 4:1 E:T ratio co-culture was used to measure IFNγ by ELISA (BD).

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PMC8623816

Subsequently, computational analysis was performed to determine the type and number of alternative splicing (AS) events in strains D122 and D122-P. The results showed that five common types of AS events could be examined, including exon skipping, intron retention, alternative 5′ss splice or alternative 3′ss splice, alternative transcription start site (TSS) and alternative transcription terminal site (TTS) (Table 1).

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PMC9878562

We applied an algorithm using mobility values to generate plots that distinguish four populations according to their migratory behavior.

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PMC10547921

Therefore, in the next generation of ADCs, it is necessary to develop structurally novel high-efficiency payloads (e.g., NAMPT inhibitors with simple structure, high activity, and special mechanism of action) with multiple mechanisms of action, higher efficacy, and fewer side effects by screening natural product libraries, chemical synthesis, and direct derivatization of natural products to improve the activity and its tolerance.

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PMC11285179

The relationship between expression levels of CEBPB and CCL28, RXRα, and ANNGPT1 were calculated online, as well as the predictive value of CEBPB for the survival of lung adenocarcinoma patients.

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PMC10988555

Some cobalt complexes can also present an antimetastatic behavior, and to evaluate this, a cell migration assay was used.

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PMC11643491

Two film-stretching methods were tested for 0.8–2.4 μm polystyrene (PS) particles: one based on solubility in organic solvents and the other on heat-induced softening.

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PMC10530622

However, these are complex and not widely available, often requiring combinations of chromatographic and mass spectrometry techniques .

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PMC9583612

Future work will focus on emissions quantification using CEMS data.

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PMC11721096

The control cells transfected with empty vector exhibited no ability to catalyze L-DOPA.

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PMC6835428

Unfortunately, no control siRNA was used, and thus the real specificity of the siRNA remains undetermined.

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PMC9429973

Methods: This is a retrospective multicentre analysis from the Transplant Complications Working Party (TCWP) of the EBMT using the data of the GoCART coalition.

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PMC10291556

Diclofenac, sodium -acetate (DCF, Figure 1) is an NSAID frequently used to treat pain; it is cost-effective and available as a generic drug.

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PMC9429973

Thirty co-morbidities were assessed using Elixhauser scoring.

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PMC11697703

Here, we show that the miR-193b∼365 microcluster: (1) is differentially expressed by developing corticospinal vs. callosal projection neurons, (2) is downstream of the selector gene Fezf2, (3) represses the callosal projection neuron-enriched signaling protein mitogen-activated protein kinase 8 (MAPK8, also known as JNK1), and (4) differentially controls dendritic morphology in deep-layer and superficial-layer neurons.

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PMC11770199

F4/80 expression in immune cells. (

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PMC11772449

This conclusion suggests that in the autophagy regulatory network, the regulatory functions of p38α and p38γ may be different, which is also one of the innovations of this study.

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PMC9917080

The zeta potential was measured using Malvern Zetasizer Ultra Red Label 10.

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PMC11790971

While in passage 1 and passage 2, cell line B exhibited unique morphological characteristics, including larger cell size and higher FAD and NAD(P)H intensities compared to other cell lines.

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PMC11665555

To identify key TFs, we performed a master regulator analysis.

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PMC11543853

In some cases, the tips of the membrane cones were attached to actin filaments that may serve as scaffolds for putative complexes, which bind to and pull on the vesicle membranes (Supplementary Fig. 1c).

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PMC3931643

All three cell lines had detectable 4EBP2 mRNA expression (Fig. S3).

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PMC10170482

We summarized all chemicals, fluorescent probes, antibodies, and TaqMan probes used in this study in Tables S1–S4 (Supporting Information), including dilutions, manufacturers’ names, and catalogue numbers.

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PMC9429973

Interestingly, we find the cohort who attended after 2007 got obvious longer PFS than those who received treatment in 2000-2006(20.6 vs 10.0 months, P=0.017), which showed a similar result in OS (31.6 vs 16.0 months, P=0.034).

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PMC10560648

In short, immediately after capture, the tentacles were manually separated from the specimens and placed directly into small glass containers filled with seawater.

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PMC11564322

Indeed, previous studies revealed that EDPs increase the proliferation of lymphocytes; however, Péterszegi et al. and Szychowski et al. have also shown that κ-elastin can stimulate the proliferation or death of lymphocytes in a concentration-dependent manner as well as the amount of FBS used in the experiments [23–25].

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PMC11394730

Piperine has a diverse mechanism of action, which gives it two unique properties as a chemopreventive agent: it can block the initiation of tumors and suppress the transformation of initiated cells into neoplastic cells .

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PMC9429973

Results: Two hundred and one consecutive MM patients, experiencing SPM ≥ 6 months since initiation of first line therapy were included in the analysis.

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PMC9429973

However, outcomes of pts after failure of both INO and Blina are not well-established, and effective treatment options for these pts are limited.

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PMC4360730

We then selected three ontologies to cover these categories: Uber anatomy ontology (Uberon), Cell Ontology (CL) and Experimental Factor Ontology (EFO) (Figure 2).

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PMC10530622

Furthermore, not only can the gut microbiota predispose, initiate, or promote the stone formation process, but the urinary microbiota has also been thought to have a role in this process, although the specific mechanisms are not completely understood .

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PMC9429973

Logistic problems at our centre with arranging central venous access, monitoring counts and timely admissions result in delays in administration.

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PMC11700340

This approach has been demonstrated to be an effective method for developing novel anti-tumor medications , An example of a medication with a prospective anticancer effect is aspirin.

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PMC11743975

Schematic diagram depicting the optogenetic-based mitochondrial aggregation system (Opto-MitoA) in cells.

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PMC11319300

These four upstream AUG sequences located in MYEOV’s 5′ untranslated region (UTR) would prevent ribosomal binding via regulation of the ribosomal entry site (Barbosa et al., 2013), abrogating the translation of the MYEOV transcript (de Almeida et al., 2006).

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PMC11734514

A similar gene expression alteration was observed in STAT-3 (100bp) (Figure 2D and E).

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PMC11461833

The sequences of STXBP5 g1, STXBP5 g2 and STXBP5 g3 are listed in Table S1.

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PMC11791264

The kinase STK4 phosphorylates LC3B at T50 to regulate the interaction of LC3B with FYCO1 and facilitate autophagosome–lysosome fusion (6, 21, 22).

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PMC11638255

A tissue microarray (TMA) was prepared using 20 Th-MYCN tumor samples (10 control, 10 TEPA-treated) in duplicate, cored at 1 mm.

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PMC9429973

Interestingly, they preferentially rely on glycolysis rather than OXPHOS for their energy demands, as shown by the positive enrichment of glycolytic genes and by the 1.4-fold higher glucose uptake of th3 HSCs.

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PMC11572213

The membranes visualized with an enhanced chemiluminescence substrate (SuperSignal, Thermo Fisher, USA) using the Azure C300 gel imaging system.

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PMC10810426

Experiments were performed 3 times.

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PMC9412887

Since most anticancer drugs are hydrophobic, if injected directly into the circulation, they not only have low bioavailability, but also have great toxicity.

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PMC11726183

N-Benzylation of isatin was carried out via a reaction of isatin with benzyl bromide in the solvent acetonitrile in the presence of potassium carbonate and potassium iodide to yield 3.

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PMC11463018

1 3 8 ∼ 139 °C.

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PMC11052306

Unfortunately, the trifluoroacetic acid used for the deprotection of the amine at the core induced a partial cleavage of the imine bonds on the surface of the dendrons and precluded the use of these dendrons for grafting to GO.

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