OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC11695546	The outcomes were tabulated as means ± SD); The MBC/MIC of the specimens ≤ 4 proposed their bactericidal impact towards H. pylori *Standard drug (0.05 mg/ml clarithromycin), Index > 4 showed their bacteriostatic action Anti-biofilm impact activity (%) of cured and ozonized coconut oil towards H. pylori were examined using (25, 50 and 75%) of MBC.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11721064	For example, Sakurai et al. reported colonies containing p63- and CK14-positive cells after five weeks of transdifferentiation .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "example", ",", "Sakurai", "et",...
PMC10568263	For grafting NHS molecules, Au@MnO2/MoO3/SPEs were first functionalized by the introduction of l-cysteine (LC).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "grafting", "NHS", "molecules", ",", ...
PMC9918897	In another flask, 0.3123 g TPTZ (2,4,6-tripyridyl-S-triazine) was dissolved in a diluted hydrochloric acid solution of 40 mmol/L, then this was also adjusted to 100 mL. The two solutions were mixed and diluted to 1 L with pH 3.6 (300 mM Na-acetate) buffer (FRAP stock solution).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11314247	This alternating process was carried out for 3 h, which was followed by cooling at −5 °C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "This", "alternating", "process", ...
PMC11451940	ESI mass spectra (m/z, corresponding species (theor.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ESI", "mass", "spectra", "(", "m/z", ",", "corresponding", "species", "(", "theor", "." ...
PMC11462673	D Knockout of the identified enhancer sequence resulted in diminished c-Myb protein expression levels.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "D", "Knockout", "of", "the", "identified", "enhancer", "sequence", ...
PMC11706491	Arrows in merged image indicate cells in G1 (cyan), S (magenta), G2 (salmon), or mitosis (green).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8873393	Cells were washed once with PBS then Alexa Fluor 488 Azide fluorophores were covalently attached to EU-containing RNA by click reaction for 1 h at room temperature.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10840195	Then, CCK-8 assays were performed to confirm the sunitinib sensitivities of the regular A498 cell line and SR-A498 cell line.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "Then", ...
PMC11772585	To prepare the homogenate solution for subsequent experiments, 0.3 mL of PBS was added for homogenization, followed by sonication in an ice water bath.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC10887351	β-AR phosphorylation is involved in the rapid desensitization and downregulation of the receptor .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "β-AR", "phosphorylation", "is", "involved", "in", "the", "rapid", "desensit...
PMC11653533	But it broadly conveyed to the regions with a maximum elevation up to 2000 m above sea level and mean yearly rainfall ranging from 500 to 1800 mm per year but a maximum of 2200 mm per year, including Zambia, Zimbabwe, Syrian Arab Republic, Cote d'Ivoire, Uganda, Swaziland, Djibouti, Tanzania, Nigeria, Angola, Sudan, Benin, Botswana, Burundi, Cameroon, Congo, Equitable Republic of Congo, Eritrea, Ethiopia, Gambia, Ghana, Guinea, Lesotho, Madagascar, Mozambique, Rwanda, Saudi Arabia, Senegal and Somalia (Kassa et al., 2015, Erhirhie et al., 2018).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11612315	Licking time was recorded for 5 min after CAP injection in each group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Licking", "time", "was", "recorded", "for", "5", "min", "after", "CAP...
PMC11495567	The complete media were removed and replaced with treatment media containing 0 μM, 0.1 μM, 0.25 μM and 0.5 μM of NSL-YHJ-2-27 or NSL-YHJ-2-46 followed by 24 h incubation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "I-CellLine", "...
PMC11451940	m/z)): 499.29 m/z [Zn(Lap)(mphen)] (499.10); 693.39 m/z [Zn(Lap)(mphen)2] (693.18).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "m/z", ")", "):", ...
PMC5854676	The use of chelating agents to improve the biodistribution of Gd towards specific target sites can lead to toxicity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "use", "of", "chelating", ...
PMC11013014	The aim is to ensure that the compounds comply with these filters and meet the necessary criteria for drug-like molecules.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "aim", "is", "to...
PMC9388315	LDHA protein expression was significantly reduced in three used concentrations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "LDHA", "protein", "expression", "was", "significantly", "reduced", "in", "three", "used", "conce...
PMC9368503	Collectively, our studies show that the ICR-SS-1 cell line model may be a valuable preclinical tool for studying the biology of anthracycline-resistant synovial sarcoma and identifying new salvage therapies following failure of doxorubicin.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11026382	Together, our simulations showed that the sign and magnitude of DHFR epistasis are strongly tuned by TYMS background, and provided quantitative predictions of the catalytic regimes where epistasis is most apparent.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4395774	For IFN-γ assay, 1 × 10 CD8 lymphoblasts labeled with 1 μg/ml anti-CD3, and 5 × 10 P815 target cells were mixed in 96-well round bottom plates and incubated for 4 hours at 37 °C.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", ...
PMC6684588	CMT mice were given unilateral injections of ACE-083 (100 µg) in the TA muscle twice weekly for 4 weeks.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CMT", "mice", "we...
PMC11679033	Obtained results indicate negligible genotoxic potential of CBD, and agree with previous observations obtained with comet assay in vitro .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Obtained", "results", "indic...
PMC11129910	Cells were washed with PBS and incubated with RIPA (Cell Signaling Technology) lysis buffer on ice.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "were", "washed", "with", "PBS...
PMC11740508	Combination treatment reduced colonies to ~ 60% of controls, while in their SUM149PT controls, colonies were reduced to about 30% of controls Colony formation attenuated by treatment with talazoparib + decitabine.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11543853	Selected tips of membrane warping are indicated by yellow arrowheads.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Selected", "tips", "of", "membrane", "warping", "are", "indicated", "by", "yellow", "arrowheads"...
PMC11087766	The phage nucleus is a viral organelle produced by phages in the Chimalliviridae family and the first DNA-enclosing viral replication compartment discovered in a prokaryotic cell (1–6).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9024365	The primary goal of this study is to further elucidate the role of SD4 in regulating GluA1- and GluA2-containing AMPARs using a structure-function approach.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11055510	The tumor weight was also determined.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "tumor", "weight", "was", "also", "determined", "." ] } ]
PMC10329074	Finally, images were captured at 0, 24 and 48 h. Bar graphs are the mean ± SD of three separate experiments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Finally...
PMC8409415	To determine the platinum sensitivity of tumors derived from A2780, A2780cisR, SKOV3, and SKOV3cisR cells, xenograft models were established for each cell line (Figure 5A‐D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", ...
PMC11224020	g, Transcription factor analysis of the different conditions.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "g", ",", "Transcription", "factor", "analysis", "of", "the", "different", "conditions", "." ] } ]
PMC11394730	The mechanism of action was mediated by necroptosis rather than the stimulation of apoptosis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "mechanism", "of", "action", "was", "mediated", "by", "nec...
PMC9429973	To our knowledge, both novel variants have not been reported in the literature.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "To", "our", "knowledge", ",", "both", "novel", "variants", "have...
PMC11696576	After treatment, the cells were washed once with PBS and stained with 1.4 μg/mL propidium iodide (PI) for 5 min before quantification of PI negative and positive cells using a CytoFLEX flow cytometer (California, United States).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	However, 4 patients developed therapy-related (t-) AML at 10.5-22 months from treatment initiation, while in 1 remission, and one Hodgkin lymphoma, for a 2-year event-free survival of 83%, if considered as events.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11411131	pTre and pCMV-Tet3G were purchased from Promega.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "pTre", "and", "pCMV-Tet3", "G", "were", "purchased", "from", "Promega", "." ] } ]
PMC11467964	Expression distributions of BMRGs between normal and STS tissues. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Expression", "distributions", "of", "BMRGs", "between", "normal", "and", "STS", "tissues", ".", ...
PMC9429973	The following data were collected: Baseline demographic variables, WBC, hemoglobin, platelet count on admission, coagulation parameters, presence/absence of disseminated intravascular coagulation, bone marrow or peripheral blood molecular analysis, immunohistochemistry, cytogenetics, Sanz score and risk stratification, timing of initiation of all trans retinoid acid (ATRA), complete response (CR) rate, major adverse events during induction, and ED rate.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	When MiBS vs SBD were compared 4 miRNA were downregulated and 5 increased on the SBD group.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "When", "MiBS", "vs", "SBD", "were", "compar...
PMC11785489	As in previous analyses, we chose one cell at random to represent each expanded clone.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "As", "in", "previous", "analyses", ",", "we", "c...
PMC11585254	Cells expressing CXCR5, Nluc-EPAC-VV, and either empty vector (pcDNA) or β-arrestin1 and β-arrestin2 were pretreated with either vehicle or 10 nM CXCL13 for 1 hour at 37°C and, after acid washing, were challenged with varying concentrations of CXCL13 in the presence of FSK (Fig. 8, A and B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11467964	Similarly, gene cluster A had higher risk scores (Figure 5C).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Similarly", ",", "gene", "cluster", "A", "had", "higher", "risk", "sc...
PMC10055960	The sigmoidal dose–response curves (Supplementary Materials, Figures S11–S13) depicting the relationship between the survival rate and the concentration of the compounds yielded half maximal inhibitory concentrations or IC50 values (95% confidence interval).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11638255	Approximately 50,000 single cells of each subset (CD3NK1.1CD11b tumor cells, CD3/NK1.1 lymphocytes and NK cells, and CD11b myeloid cells) were sorted into a single tube containing fetal bovine serum (Gibco, USA; #10100-147) using the BD FACSAria III (BD Biosciences, USA).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10969097	Gou et al. , when analysing the effects of the combination of polysaccharides from Trametes robiniophila Murr with the drug oxaliplatin in HepG2 and Bel-7404 cells, were able to demonstrate that polysaccharides from Trametes robiniophila Murr had a strong ability to reduce the viability and growth rate of these cancer cells, and the combination of polysaccharides from Trametes robiniophila Murr with oxaliplatin had a more pronounced inhibitory effect than using oxaliplatin alone.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "...
PMC11721587	Data are means ± SD. *	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "means", "±", "SD", ".", "*" ] } ]
PMC10761571	Cell apoptosis occurs through two main pathways, including the extrinsic or cytoplasmic pathway and the intrinsic or mitochondrial pathway.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", "apoptosis", "occurs"...
PMC11640555	GBM sections were incubated overnight (O/N) using the following primary antibodies: anti-Ki67 (Cat #MA5-14520; 1:100 in PBS, v/v; Invitrogen; Waltham, MA, USA) as proliferation activity marker and TGF-β as an oncogenic marker.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC2777936	Transfection of siRNAs was accomplished with OligofectAMINE (Invitrogen, CA), as previously described .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Transfection", "of", "siRNAs", "was", "accomplished", ...
PMC11761919	Phthalyl inulin nanoparticles (PINs) are self-assembled and synthesized during dialysis in cold distilled water.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Phthalyl", "inulin", "nanoparticles", "(", "PINs", ")"...
PMC7582629	Thanks to its label-free and non-destructive nature, Raman imaging can be successfully applied to non-invasively image living human cancer cells and to study the internalization kinetics and localization of drug nanovectors .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7841067	The average band intensities of Shh, Smo, Ptc, and Gli-1 normalized to GAPDH.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "average", "band", "intensities", "of", "Shh", ...
PMC11277157	For the PCA (Figure 2B), we have included all 18k identified transcripts from the RNA-seq results (Supplementary Table S2).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC10502403	NY-ESO-1-specific response and persistence of NE1-GMCs and comparison of the effects of metabolic inhibition on IFN-γ secretion between NGMCs and NE1-GMCs (A) Frequencies of IFN-γ-secreting cells in NGMC Vδ2 cells and NE1-GMC Vδ2CD8 cells in media with different 2-DG concentrations.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11695623	LINC00880 can act as a protein scaffold between CDK1 and PRDX1, forming a ternary complex, which leads to the activation of PI3K/AKT and promotes the occurrence of malignant tumor.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11574271	In contrast, inhibition of RON in J82-oeRON cells led to a reduction of HIF-2α expression, which is associated with decreased JNK activity and downregulation of MMP12 expression.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5916734	This method of FIX production requires neither using specialized perfusion bioreactors nor elaborating methods to maintain cell culture viability for a long time, making industrial production of recombinant human factor IX much simpler and cheaper.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11806818	The methods for identifying CTCs mainly include immunofluorescence , fluorescence in situ hybridization , reverse transcription polymerase chain reaction (RT-PCR) , Real-time PCR (RT-PCR) , and flow cytometry .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11544122	Binding was quantified by densitometric analysis of FLAG (c) or HIS Immunoblots (d) using Image J software and normalized to GST or GST-CT.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Fedratinib (FEDR), approved in August 2019, is active against wild-type and mutationally activated JAK2 and receptor tyrosine kinase FLT3, but its real-world effectiveness in patients discontinuing RUX has not been evaluated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11342785	We noted that the number of TPPP clusters generated using the OptoDroplets system was high and potentially too finely dispersed to coalesce into higher-order architectures on the timescales accessible to light-stimulation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11422497	A significance level of P < 0.05 was considered statistically significant.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "significance", "level", "of", "P", "<", "0.05", "was", "considered", "statistica...
PMC11706776	The increase in intracellular calcium concentration in turn promotes proliferation through calcium signaling.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "increase", "in", "intracellular", "calcium", "concentration", "in", ...
PMC11144382	In contrast, the NFIX DupG mutation caused a 2.5-fold reduction (n = 4, P <0 .0001) in luciferase activity compared with WT NFIX (Figure 1E), confirming a partial loss of function of NFIX transactivation activity at the GFAP locus, and consistent with results obtained in the MSS NFIX c.1090dupG patient fibroblasts.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Chronic lymphocytic leukemia (CLL) is a prototype disease in which BCR-BCR self-interactions induce autonomous signaling.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Chronic", "lymphocytic", "leukemia", "(", "CLL", ...
PMC8358006	The Hi-C maps of regions were visualized using Juicebox v1.11.08.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "Hi-C", "maps", "of", "regions", "were", "visualized", "using", "Juicebox", "v1.11.08", ...
PMC11155445	In silico study indicated good pharmacokinetic properties and drug-like characteristics for these derivatives.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "silico", "study", "indicated", "good", "pharmacokinetic", "properties", ...
PMC5417661	At the 10 µM concentration NOV202 was sufficient to block the polymerization almost completely while at 1.0 µM concentration the compound slowed down the rate of the polymerization, but could not suppress it.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11699042	f Ranking plots depicting the linear distribution of five EwS cell lines based on their evolution across different datasets after continuous culturing for 12 months.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11792090	Statistical significance was determined by one-way ANOVA (D, E) and Student’s t-test (G, H). ***	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC11388384	SCUBE is known to promote SHH secretion (13, 14), and under the topology-limited model, secretion of SHH is similar to SHH diffusion, in that both processes can be mechanistically controlled by increasing the rate at which SHH transitions from the membrane-confined population to the free population that can jump between cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11742290	In the presence of R-spondin (RSPO), LGR5 binds to RSPO, RNF43/ZNRF3 is neutralized, and intracellular β-catenin is accumulated and increased, leading to enhanced activation of the WNT signaling pathway.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	In comparison with outpatients, hospitalized cases had a significantly lower median values of hemoglobin (12.1 vs. 13.3 g/dL, p<.001), platelets (250 vs. 390 x10/L, p<.001), absolute lymphocytes (0.8 vs. 1.4 x10/L, p<.001) and higher neutrophil counts (5.1 vs. 4.5 x10/L, p=0.022), leading to a significant increase of neutrophil to lymphocyte ratio (NLR) (6.6 vs. 3.2, p<.001).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11406030	More importantly, we designed LMTK3 binding peptides that specifically target LMTK3.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "More", "importantly", ",", "we", "designed", "LMTK3", "binding", "peptides", "th...
PMC10955424	Hazem Khamaisi: Methodology.	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "Hazem", "Khamaisi", ":", "Methodology", "." ] } ]
PMC9429973	Image: Summary/Conclusion: Carriers of TERT variants with CADD score of >20 were more likely to be associated with a diagnosis of MDS and with somatic TP53 mutations in comparison to those with CADD score <20, findings that we plan to validate functionally and prospectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	The number of α genes plays a very important role in the thalassemia phenotype.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "number", "of", "α", "genes", "plays", "a", "very", ...
PMC11612626	Cells (30,000/well) were seeded into 96-well, black-walled clear bottom plates in a final volume of 100 μL/well.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cells", "(", "30,000/well", ...
PMC9812014	Although most HPIV illnesses are minor and self-limiting, serious infections that require hospitalisation can also happen, especially in newborns, youngsters, and people with impaired immune systems .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11746942	Regarding the association between S1PR3 and STAT3, we found Src was the major intermediate of S1PR3-mediated STAT3 activation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Regarding", "the", "association", ...
PMC7090062	Besides, confocal laser scanning microscopy and electron microscopy showed that the numbers of LC3 puncta and autophagic vacuoles were significantly reduced in cells overexpressing miR-30a, while the LC3 puncta formation and autophagic vacuoles were increased in GST cells following the introduction of the miR-30a inhibitor (Fig. 3e, f).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11635519	Overview of the screening platform developed to discover agonist or antagonist peptides of human GPCRs.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Overview", "of", "the", "screening", "platform", "developed", ...
PMC9429973	Methods: We retrospectively analyzed immunohistochemistry (IHC) results of biopted tumor tissue of 537 pts with DLBCL NOS.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Methods", ":", "We", "...
PMC6627640	We also considered whether there was a common set of genes upregulated in the resistant cell lines as compared with each matching parental cell lines.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11783017	The encapsulation of cisplatin in Cis/Mn@Lipo-IL11 and its release in the tumor microenvironment in the presence of GSH were further validated using UV spectrum (Fig. S4).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11442172	Although diminished, mitochondrial-dependent metabolism did remain active at hypoxia (31, 33).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Although", "diminished", ",", "mitochondrial-dependent", "metabolism", ...
PMC11204465	Compound 20 showed moderate bacteriostatic activity against Staphylococcus aureus ATCC25923 and Vibrio parahaemolyticus ATCC17802 .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Compound", "20", "showed", "moderate", "bacteriostatic", "activity", "...
PMC11699178	A PPI network of genes interacting with HIF-1α among significant DEGs; B Correlation heatmap of genes interacting with HIF-1α; C Boxplots of expression levels of VEGF-B, PROX1, SOD2 (control-OVCAR3, n = 3, GEM-OVCAR3, n = 3); D–F Boxplots of expression levels of VEGF-B (D), PROX1 (E), SOD2 (F) in TCGA_GTEx-OV dataset, where * indicates P < 0.05, indicates P < 0.01, * indicates P < 0.001 (TCGA_GTEx-OV dataset: Normal: n = 88, Tumor: n = 427); (G) PPI network of genes interacting with VEGF-B among significantly DEGs; (H) Boxplots of expression levels of FGF2 and FGFR1 (control-OVCAR3, n = 3, GEM-OVCAR3, n = 3) Additionally, further analysis revealed an interaction between VEGFB and 9 DEGs (Fig. 3G).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9985266	P < 0.05, P < 0.01, *P < 0.001; values are expressed as the mean ± standard deviation (n = 3) MEG3 attenuates TGF-β1-induced fibrosis by activating autophagy through inhibition of the ERK/p38 pathway in MRC-5 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8382973	Data are expressed as means ± standard deviations (SD).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Data", "are", "expressed", "as", "means", "±", "standard", "deviations", "(", "SD", ...
PMC2196094	Six of these proteases have not been isolated previously.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Six", "of", "these", "proteases", "have", "not", "been", "isolated", "previously", "." ] } ]
PMC9275501	The bioadhesion between FA and its receptors significantly increased the uptake of FA-LB-MSNs by NB4 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O" ], "tokens": [ "The", "bioadhesion", "between", "FA", "and", ...
PMC11473843	Contrary, expression of a loss-of-function point mutant of FAK at position 397 (FAK), a phosphorylation site which is essential for FAK activity, only partially rescued cell proliferation and triggered a similar suppression of colony forming capacity compared to the empty vector control in presence of mutKRAS (Fig. EV1C–E).Figure 1ERK5 and CDK5 are key regulators of FAK function in mutant KRAS NSCLC.(A) Scheme depicting the critical dependency of KRAS mutant cancer cells on FAK. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7189327	Meanwhile, they were focused on 54 GO-CC terms such as intracellular part, intracellular, and cytoplasm.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Meanwhile", ",", "they", "were", "focu...
PMC5854676	Control HeLa cells. (	[ { "tags": [ "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "Control", "HeLa", "cells", ".", "(" ] } ]
PMC9429973	Mice were given intraperitoneal injection of BTZ (1 mg/kg on days 1, 4, 8 and 11) to establish a BIPN model.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11543935	The histological section presented in Fig. 5A has a calculated value of COVd = 0.49.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "histological", "section", "presented", "in", "Fig.", ...
PMC10565698	G. Construction of WT and MUT sequences of TCF12 with an miR-211-5p binding site.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "G.", "Construction", "of", "WT", "and", "MUT", "...

PMC11695546

The outcomes were tabulated as means ± SD); The MBC/MIC of the specimens ≤ 4 proposed their bactericidal impact towards H. pylori *Standard drug (0.05 mg/ml clarithromycin), Index > 4 showed their bacteriostatic action Anti-biofilm impact activity (%) of cured and ozonized coconut oil towards H. pylori were examined using (25, 50 and 75%) of MBC.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11721064

For example, Sakurai et al. reported colonies containing p63- and CK14-positive cells after five weeks of transdifferentiation .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "example", ",", "Sakurai", "et",...

PMC10568263

For grafting NHS molecules, Au@MnO2/MoO3/SPEs were first functionalized by the introduction of l-cysteine (LC).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "For", "grafting", "NHS", "molecules", ",", ...

PMC9918897

In another flask, 0.3123 g TPTZ (2,4,6-tripyridyl-S-triazine) was dissolved in a diluted hydrochloric acid solution of 40 mmol/L, then this was also adjusted to 100 mL. The two solutions were mixed and diluted to 1 L with pH 3.6 (300 mM Na-acetate) buffer (FRAP stock solution).

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PMC11314247

This alternating process was carried out for 3 h, which was followed by cooling at −5 °C.

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PMC11451940

ESI mass spectra (m/z, corresponding species (theor.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "ESI", "mass", "spectra", "(", "m/z", ",", "corresponding", "species", "(", "theor", "." ...

PMC11462673

D Knockout of the identified enhancer sequence resulted in diminished c-Myb protein expression levels.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "D", "Knockout", "of", "the", "identified", "enhancer", "sequence", ...

PMC11706491

Arrows in merged image indicate cells in G1 (cyan), S (magenta), G2 (salmon), or mitosis (green).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8873393

Cells were washed once with PBS then Alexa Fluor 488 Azide fluorophores were covalently attached to EU-containing RNA by click reaction for 1 h at room temperature.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10840195

Then, CCK-8 assays were performed to confirm the sunitinib sensitivities of the regular A498 cell line and SR-A498 cell line.

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PMC11772585

To prepare the homogenate solution for subsequent experiments, 0.3 mL of PBS was added for homogenization, followed by sonication in an ice water bath.

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PMC10887351

β-AR phosphorylation is involved in the rapid desensitization and downregulation of the receptor .

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PMC11653533

But it broadly conveyed to the regions with a maximum elevation up to 2000 m above sea level and mean yearly rainfall ranging from 500 to 1800 mm per year but a maximum of 2200 mm per year, including Zambia, Zimbabwe, Syrian Arab Republic, Cote d'Ivoire, Uganda, Swaziland, Djibouti, Tanzania, Nigeria, Angola, Sudan, Benin, Botswana, Burundi, Cameroon, Congo, Equitable Republic of Congo, Eritrea, Ethiopia, Gambia, Ghana, Guinea, Lesotho, Madagascar, Mozambique, Rwanda, Saudi Arabia, Senegal and Somalia (Kassa et al., 2015, Erhirhie et al., 2018).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11612315

Licking time was recorded for 5 min after CAP injection in each group.

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PMC11495567

The complete media were removed and replaced with treatment media containing 0 μM, 0.1 μM, 0.25 μM and 0.5 μM of NSL-YHJ-2-27 or NSL-YHJ-2-46 followed by 24 h incubation.

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PMC11451940

m/z)): 499.29 m/z [Zn(Lap)(mphen)] (499.10); 693.39 m/z [Zn(Lap)(mphen)2] (693.18).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "m/z", ")", "):", ...

PMC5854676

The use of chelating agents to improve the biodistribution of Gd towards specific target sites can lead to toxicity.

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PMC11013014

The aim is to ensure that the compounds comply with these filters and meet the necessary criteria for drug-like molecules.

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PMC9388315

LDHA protein expression was significantly reduced in three used concentrations.

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PMC9368503

Collectively, our studies show that the ICR-SS-1 cell line model may be a valuable preclinical tool for studying the biology of anthracycline-resistant synovial sarcoma and identifying new salvage therapies following failure of doxorubicin.

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PMC11026382

Together, our simulations showed that the sign and magnitude of DHFR epistasis are strongly tuned by TYMS background, and provided quantitative predictions of the catalytic regimes where epistasis is most apparent.

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PMC4395774

For IFN-γ assay, 1 × 10 CD8 lymphoblasts labeled with 1 μg/ml anti-CD3, and 5 × 10 P815 target cells were mixed in 96-well round bottom plates and incubated for 4 hours at 37 °C.

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PMC6684588

CMT mice were given unilateral injections of ACE-083 (100 µg) in the TA muscle twice weekly for 4 weeks.

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PMC11679033

Obtained results indicate negligible genotoxic potential of CBD, and agree with previous observations obtained with comet assay in vitro .

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PMC11129910

Cells were washed with PBS and incubated with RIPA (Cell Signaling Technology) lysis buffer on ice.

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PMC11740508

Combination treatment reduced colonies to ~ 60% of controls, while in their SUM149PT controls, colonies were reduced to about 30% of controls Colony formation attenuated by treatment with talazoparib + decitabine.

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PMC11543853

Selected tips of membrane warping are indicated by yellow arrowheads.

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PMC11087766

The phage nucleus is a viral organelle produced by phages in the Chimalliviridae family and the first DNA-enclosing viral replication compartment discovered in a prokaryotic cell (1–6).

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PMC9024365

The primary goal of this study is to further elucidate the role of SD4 in regulating GluA1- and GluA2-containing AMPARs using a structure-function approach.

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PMC11055510

The tumor weight was also determined.

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PMC10329074

Finally, images were captured at 0, 24 and 48 h. Bar graphs are the mean ± SD of three separate experiments.

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PMC8409415

To determine the platinum sensitivity of tumors derived from A2780, A2780cisR, SKOV3, and SKOV3cisR cells, xenograft models were established for each cell line (Figure 5A‐D).

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PMC11224020

g, Transcription factor analysis of the different conditions.

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PMC11394730

The mechanism of action was mediated by necroptosis rather than the stimulation of apoptosis.

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PMC9429973

To our knowledge, both novel variants have not been reported in the literature.

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PMC11696576

After treatment, the cells were washed once with PBS and stained with 1.4 μg/mL propidium iodide (PI) for 5 min before quantification of PI negative and positive cells using a CytoFLEX flow cytometer (California, United States).

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PMC9429973

However, 4 patients developed therapy-related (t-) AML at 10.5-22 months from treatment initiation, while in 1 remission, and one Hodgkin lymphoma, for a 2-year event-free survival of 83%, if considered as events.

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PMC11411131

pTre and pCMV-Tet3G were purchased from Promega.

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PMC11467964

Expression distributions of BMRGs between normal and STS tissues. (

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PMC9429973

The following data were collected: Baseline demographic variables, WBC, hemoglobin, platelet count on admission, coagulation parameters, presence/absence of disseminated intravascular coagulation, bone marrow or peripheral blood molecular analysis, immunohistochemistry, cytogenetics, Sanz score and risk stratification, timing of initiation of all trans retinoid acid (ATRA), complete response (CR) rate, major adverse events during induction, and ED rate.

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PMC9429973

When MiBS vs SBD were compared 4 miRNA were downregulated and 5 increased on the SBD group.

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PMC11785489

As in previous analyses, we chose one cell at random to represent each expanded clone.

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PMC11585254

Cells expressing CXCR5, Nluc-EPAC-VV, and either empty vector (pcDNA) or β-arrestin1 and β-arrestin2 were pretreated with either vehicle or 10 nM CXCL13 for 1 hour at 37°C and, after acid washing, were challenged with varying concentrations of CXCL13 in the presence of FSK (Fig. 8, A and B).

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PMC11467964

Similarly, gene cluster A had higher risk scores (Figure 5C).

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PMC10055960

The sigmoidal dose–response curves (Supplementary Materials, Figures S11–S13) depicting the relationship between the survival rate and the concentration of the compounds yielded half maximal inhibitory concentrations or IC50 values (95% confidence interval).

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PMC11638255

Approximately 50,000 single cells of each subset (CD3NK1.1CD11b tumor cells, CD3/NK1.1 lymphocytes and NK cells, and CD11b myeloid cells) were sorted into a single tube containing fetal bovine serum (Gibco, USA; #10100-147) using the BD FACSAria III (BD Biosciences, USA).

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PMC10969097

Gou et al. , when analysing the effects of the combination of polysaccharides from Trametes robiniophila Murr with the drug oxaliplatin in HepG2 and Bel-7404 cells, were able to demonstrate that polysaccharides from Trametes robiniophila Murr had a strong ability to reduce the viability and growth rate of these cancer cells, and the combination of polysaccharides from Trametes robiniophila Murr with oxaliplatin had a more pronounced inhibitory effect than using oxaliplatin alone.

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PMC11721587

Data are means ± SD. *

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PMC10761571

Cell apoptosis occurs through two main pathways, including the extrinsic or cytoplasmic pathway and the intrinsic or mitochondrial pathway.

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PMC11640555

GBM sections were incubated overnight (O/N) using the following primary antibodies: anti-Ki67 (Cat #MA5-14520; 1:100 in PBS, v/v; Invitrogen; Waltham, MA, USA) as proliferation activity marker and TGF-β as an oncogenic marker.

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PMC2777936

Transfection of siRNAs was accomplished with OligofectAMINE (Invitrogen, CA), as previously described .

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PMC11761919

Phthalyl inulin nanoparticles (PINs) are self-assembled and synthesized during dialysis in cold distilled water.

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PMC7582629

Thanks to its label-free and non-destructive nature, Raman imaging can be successfully applied to non-invasively image living human cancer cells and to study the internalization kinetics and localization of drug nanovectors .

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PMC7841067

The average band intensities of Shh, Smo, Ptc, and Gli-1 normalized to GAPDH.

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PMC11277157

For the PCA (Figure 2B), we have included all 18k identified transcripts from the RNA-seq results (Supplementary Table S2).

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PMC10502403

NY-ESO-1-specific response and persistence of NE1-GMCs and comparison of the effects of metabolic inhibition on IFN-γ secretion between NGMCs and NE1-GMCs (A) Frequencies of IFN-γ-secreting cells in NGMC Vδ2 cells and NE1-GMC Vδ2CD8 cells in media with different 2-DG concentrations.

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PMC11695623

LINC00880 can act as a protein scaffold between CDK1 and PRDX1, forming a ternary complex, which leads to the activation of PI3K/AKT and promotes the occurrence of malignant tumor.

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PMC11574271

In contrast, inhibition of RON in J82-oeRON cells led to a reduction of HIF-2α expression, which is associated with decreased JNK activity and downregulation of MMP12 expression.

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PMC5916734

This method of FIX production requires neither using specialized perfusion bioreactors nor elaborating methods to maintain cell culture viability for a long time, making industrial production of recombinant human factor IX much simpler and cheaper.

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PMC11806818

The methods for identifying CTCs mainly include immunofluorescence , fluorescence in situ hybridization , reverse transcription polymerase chain reaction (RT-PCR) , Real-time PCR (RT-PCR) , and flow cytometry .

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PMC11544122

Binding was quantified by densitometric analysis of FLAG (c) or HIS Immunoblots (d) using Image J software and normalized to GST or GST-CT.

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PMC9429973

Fedratinib (FEDR), approved in August 2019, is active against wild-type and mutationally activated JAK2 and receptor tyrosine kinase FLT3, but its real-world effectiveness in patients discontinuing RUX has not been evaluated.

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PMC11342785

We noted that the number of TPPP clusters generated using the OptoDroplets system was high and potentially too finely dispersed to coalesce into higher-order architectures on the timescales accessible to light-stimulation.

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PMC11422497

A significance level of P < 0.05 was considered statistically significant.

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PMC11706776

The increase in intracellular calcium concentration in turn promotes proliferation through calcium signaling.

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PMC11144382

In contrast, the NFIX DupG mutation caused a 2.5-fold reduction (n = 4, P <0 .0001) in luciferase activity compared with WT NFIX (Figure 1E), confirming a partial loss of function of NFIX transactivation activity at the GFAP locus, and consistent with results obtained in the MSS NFIX c.1090dupG patient fibroblasts.

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PMC9429973

Chronic lymphocytic leukemia (CLL) is a prototype disease in which BCR-BCR self-interactions induce autonomous signaling.

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PMC8358006

The Hi-C maps of regions were visualized using Juicebox v1.11.08.

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PMC11155445

In silico study indicated good pharmacokinetic properties and drug-like characteristics for these derivatives.

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PMC5417661

At the 10 µM concentration NOV202 was sufficient to block the polymerization almost completely while at 1.0 µM concentration the compound slowed down the rate of the polymerization, but could not suppress it.

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PMC11699042

f Ranking plots depicting the linear distribution of five EwS cell lines based on their evolution across different datasets after continuous culturing for 12 months.

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PMC11792090

Statistical significance was determined by one-way ANOVA (D, E) and Student’s t-test (G, H). ***

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PMC11388384

SCUBE is known to promote SHH secretion (13, 14), and under the topology-limited model, secretion of SHH is similar to SHH diffusion, in that both processes can be mechanistically controlled by increasing the rate at which SHH transitions from the membrane-confined population to the free population that can jump between cells.

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PMC11742290

In the presence of R-spondin (RSPO), LGR5 binds to RSPO, RNF43/ZNRF3 is neutralized, and intracellular β-catenin is accumulated and increased, leading to enhanced activation of the WNT signaling pathway.

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PMC9429973

In comparison with outpatients, hospitalized cases had a significantly lower median values of hemoglobin (12.1 vs. 13.3 g/dL, p<.001), platelets (250 vs. 390 x10/L, p<.001), absolute lymphocytes (0.8 vs. 1.4 x10/L, p<.001) and higher neutrophil counts (5.1 vs. 4.5 x10/L, p=0.022), leading to a significant increase of neutrophil to lymphocyte ratio (NLR) (6.6 vs. 3.2, p<.001).

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PMC11406030

More importantly, we designed LMTK3 binding peptides that specifically target LMTK3.

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PMC10955424

Hazem Khamaisi: Methodology.

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PMC9429973

Image: Summary/Conclusion: Carriers of TERT variants with CADD score of >20 were more likely to be associated with a diagnosis of MDS and with somatic TP53 mutations in comparison to those with CADD score <20, findings that we plan to validate functionally and prospectively.

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PMC9429973

The number of α genes plays a very important role in the thalassemia phenotype.

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PMC11612626

Cells (30,000/well) were seeded into 96-well, black-walled clear bottom plates in a final volume of 100 μL/well.

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PMC9812014

Although most HPIV illnesses are minor and self-limiting, serious infections that require hospitalisation can also happen, especially in newborns, youngsters, and people with impaired immune systems .

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PMC11746942

Regarding the association between S1PR3 and STAT3, we found Src was the major intermediate of S1PR3-mediated STAT3 activation.

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PMC7090062

Besides, confocal laser scanning microscopy and electron microscopy showed that the numbers of LC3 puncta and autophagic vacuoles were significantly reduced in cells overexpressing miR-30a, while the LC3 puncta formation and autophagic vacuoles were increased in GST cells following the introduction of the miR-30a inhibitor (Fig. 3e, f).

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PMC11635519

Overview of the screening platform developed to discover agonist or antagonist peptides of human GPCRs.

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PMC9429973

Methods: We retrospectively analyzed immunohistochemistry (IHC) results of biopted tumor tissue of 537 pts with DLBCL NOS.

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PMC6627640

We also considered whether there was a common set of genes upregulated in the resistant cell lines as compared with each matching parental cell lines.

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PMC11783017

The encapsulation of cisplatin in Cis/Mn@Lipo-IL11 and its release in the tumor microenvironment in the presence of GSH were further validated using UV spectrum (Fig. S4).

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PMC11442172

Although diminished, mitochondrial-dependent metabolism did remain active at hypoxia (31, 33).

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PMC11204465

Compound 20 showed moderate bacteriostatic activity against Staphylococcus aureus ATCC25923 and Vibrio parahaemolyticus ATCC17802 .

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PMC11699178

A PPI network of genes interacting with HIF-1α among significant DEGs; B Correlation heatmap of genes interacting with HIF-1α; C Boxplots of expression levels of VEGF-B, PROX1, SOD2 (control-OVCAR3, n = 3, GEM-OVCAR3, n = 3); D–F Boxplots of expression levels of VEGF-B (D), PROX1 (E), SOD2 (F) in TCGA_GTEx-OV dataset, where * indicates P < 0.05, ** indicates P < 0.01, *** indicates P < 0.001 (TCGA_GTEx-OV dataset: Normal: n = 88, Tumor: n = 427); (G) PPI network of genes interacting with VEGF-B among significantly DEGs; (H) Boxplots of expression levels of FGF2 and FGFR1 (control-OVCAR3, n = 3, GEM-OVCAR3, n = 3) Additionally, further analysis revealed an interaction between VEGFB and 9 DEGs (Fig. 3G).

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PMC9985266

P < 0.05, **P < 0.01, ***P < 0.001; values are expressed as the mean ± standard deviation (n = 3) MEG3 attenuates TGF-β1-induced fibrosis by activating autophagy through inhibition of the ERK/p38 pathway in MRC-5 cells.

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PMC8382973

Data are expressed as means ± standard deviations (SD).

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PMC2196094

Six of these proteases have not been isolated previously.

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PMC9275501

The bioadhesion between FA and its receptors significantly increased the uptake of FA-LB-MSNs by NB4 cells.

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PMC11473843

Contrary, expression of a loss-of-function point mutant of FAK at position 397 (FAK), a phosphorylation site which is essential for FAK activity, only partially rescued cell proliferation and triggered a similar suppression of colony forming capacity compared to the empty vector control in presence of mutKRAS (Fig. EV1C–E).Figure 1ERK5 and CDK5 are key regulators of FAK function in mutant KRAS NSCLC.(A) Scheme depicting the critical dependency of KRAS mutant cancer cells on FAK. (

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PMC7189327

Meanwhile, they were focused on 54 GO-CC terms such as intracellular part, intracellular, and cytoplasm.

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PMC5854676

Control HeLa cells. (

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PMC9429973

Mice were given intraperitoneal injection of BTZ (1 mg/kg on days 1, 4, 8 and 11) to establish a BIPN model.

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PMC11543935

The histological section presented in Fig. 5A has a calculated value of COVd = 0.49.

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PMC10565698

G. Construction of WT and MUT sequences of TCF12 with an miR-211-5p binding site.

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