OTAR3088/BioData-CellLine_annotated · Datasets at Hugging Face

PMCID string	Sentences string	ner list
PMC9429973	Therefore, patients with relapsed/refractory (R/R) disease represent a high unmet need, and new targets and treatment modalities are needed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Therefo...
PMC9985266	Each experiment was repeated 3 times independently.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Each", "experiment", "was", "repeated", "3", "times", "independently", "." ] } ]
PMC11240571	In 143B cells, exosome markers CD9, CD63, and CD81 were detected (Supplemental Figure S2B).	[ { "tags": [ "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "143B", "cells", ",...
PMC11411004	This indicates that I-4 can effectively inhibit the expression of HDAC and LSD1 in cells, thereby increasing the methylation and acetylation levels of histone H3.Fig.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...
PMC11794588	There are around 300 species of the genus Cestrum (Family Solanaceae), which is extensively spread in tropical and subtropical regions of the world, including Bangladesh, India, the United States, Australia, South America, and southern China.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11767725	Moreover, IGF-1 suppresses the nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR-γ), disrupting sebocyte differentiation and lipid homeostasis, which further contributes to sebaceous gland dysfunction .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8494202	Finally, we obtained the 2D and 3D structures and molecular formulas of these drugs from PubChem, as shown in Figure 10.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Finally...
PMC11629192	Jie Hong: Resources, Project administration, Methodology, Formal analysis, Data curation, Conceptualization.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Jie", "Hong", ":", "Resources", ",", "Proje...
PMC11638255	A two-way ANOVA with Sidak’s multiple comparisons test was used to identify differences between two models with two treatments.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "two-way", "ANOVA", ...
PMC9429973	Blood tests showed bicytopenia (hemoglobin 10.8 g/dL normocytic/normochromic and leukocyte 2.1x10^9/L), an elevated C-reactive protein (14 mg/dl) and an elevated erythrocyte sedimentation rate (85 mm/h); lactate dehydrogenase (LDH), kidney function and liver function analysis were unremarkable.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Results: At diagnosis, microbial diversity index of the patient group was lower than that of their siblings.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "At", "diagnosis",...
PMC9429973	Day 30 and day 60 mortality rates were 13% (2/15) and 20% (3/15), respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Day", "30", "and"...
PMC10999934	Data was processed based on specific quality control standards: 1) cells were screened for at least 100 genes detected, with genes expressed in less than 3 cells being excluded; 2) cells with nuclear gene counts below 200 or above 6000 and at least 50% mitochondrial genes were eliminated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10198699	The same applies to HBM.	[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "same", "applies", "to", "HBM", "." ] } ]
PMC9386809	327 mg (93% yield); white solid mp 189–191 °C; H NMR (400 MHz, DMSO-d6): δ 3.71 (s, 3H, OCH3), 5.78 (s, 1H, CH), 6.81–6.89 (m, 6H, Ar and CH=C), 7.02–7.04 (m, 2H, Ar), 7.05–7.37 (m, 6H, Ar), 10.81 (d, 1H, J = 1.76 Hz NH); C NMR (100 MHz, DMSO-d6): δ 55.4, 111.9, 113.8, 118.6, 118.9, 119.6, 121.3, 123.9, 127.1, 129.7, 137.1, 137.4, 157.7.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11680391	The increase in the production level may also increase the incidence of production-related diseases (Gröhn et al. (1995)) , and dairy veterinarians today therefore need an economic mindset to allow them to focus on the costliest production diseases in dairy cows .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC5810978	We tested six cell lines (HIEC, HT29-Cl.16E, Caco-2, JVM-2, IPEC-J2, and Vero cells) and four HuNoV strains (one GII.2, two GII.4, and one GII.6).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", ...
PMC11543885	Hemagglutinin (HA) epitope should be avoided because biotin-phenoxyl radicals are highly reactive towards the tyrosine present in the HA sequence.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hemagglutinin", ...
PMC11049548	In line with this, the decrement of UDP-NAcGlc and NAcGal are considered markers for cancer aggressiveness .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "line", "with", "this", ",", "the", ...
PMC9429973	Cohorts composed by fulfilling inclusion and exclusion criteria in clinical trials were excluded.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cohorts", "composed", "by", "fulfilling", "inclusion", "and", "exclusion", ...
PMC11629192	The worst mRS was 5 and worst CASE was 24.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "worst", "mRS", "was", "5", "and", "worst", "CASE", "was", "24", "." ] } ]
PMC11666785	Although the number of molecules for reconstructed image with χ > 0.9 is less than χ > 0.7 and χ > 0.8, key features are well preserved.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC4659567	Calcd.	[ { "tags": [ "O", "O" ], "tokens": [ "Calcd", "." ] } ]
PMC11569208	FC Fold-change.	[ { "tags": [ "O", "O", "O" ], "tokens": [ "FC", "Fold-change", "." ] } ]
PMC10877303	Different binding modes for the selected compounds within the MERS-CoV 3CL protein's active and catalytic sites; (A) Kihadanin B, (B) Robustaflavone, (C) 3-beta-O-(trans-p-Coumaroyl)maslinic acid.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11367939	Scale bars, A 5 μm (left) or 2 μm (right).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Scale", "bars", ",", "A", "5", "μm", "(", "left", ...
PMC11495567	Consequently, earlier efforts to develop anti-RAS drugs centered on the synthesis of farnesylation inhibitors as it was observed that the C-terminal farnesyl cysteine is essential for RAS membrane localization and function .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	Among patients with HGBCL, 19 achieved a complete response (CR), 3 manifested resistant disease (RD) and for 3 patients response assessment was not possible due to disease related early death.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11762280	The relative protein levels of the interested proteins were compared with ACTB as quantification (n = 3).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "relative", "protein", "lev...
PMC9429973	Identifying disrupted gene pathways specific for each SLA should therefore form the basis for targeted therapies aimed at inducing AML differentiation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Identifying", "disrupte...
PMC10831439	For the generation of CD19-CAR-iNKT cells, the original protocol for T cells had to be adapted considering several unique properties of iNKT cells.32 The protocol, which was established for this work, consisted of upfront iNKT-cell isolation and activation using α-GalCer-loaded autologous feeder cells, IL-2 and α-GalCer (online supplemental data 1A).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC8316344	Ferroptosis and iron metabolism are intimately associated.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Ferroptosis", "and", "iron", "metabolism", "are", "intimately", "associated", "." ] } ]
PMC9429973	Image: Summary/Conclusion: Our primary data of the phase I trial have proved the primary efficacy and safety of CD33 CAR NK cells for patients with R/R AML.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11489175	USP8 removes K48 and K63 linked poly-Ub chains from substrates thereby participating in refilling of the ubiquitin cell pool and has been implicated in EGFR regulation and endosomal sorting and in protection from degradation 13, 14.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11678130	CM is a heterogeneous tumor characterized by genetically divergent subpopulations, including CSCs .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "CM", "is", "a", "heterogeneous", "tumor", "characterized", "by", "genetical...
PMC10213199	Rich factor is the ratio of the differentially expressed number of genes in the pathway and the total number of genes in the pathway.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	Only one patient treated with carfilzomib-based therapies achieved a clinical response.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Only", "one", "patient", "treated", "with", "carfilzomib-based", "therapies", "achieved", "...
PMC11306019	These SMILES notations were then input into the online tool ChemGPS-NPWeb (http://chemgps.bmc.uu.se) to obtain the ChemGPS-NP scores, as described previously (Larsson et al., 2007; Rosén et al., 2009; Korinek et al., 2017).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11637276	p < 0.0001; Kruskal–Wallis test. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "p", "<", "0.0001", ";", "Kruskal", "–", "Wallis", "test", ".", "(" ] } ]
PMC11657744	Data are presented as the mean ± SD, with statistical significance determined by two-sided unpaired Student’s t tests in GraphPad Prism. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ ...
PMC9429973	These were: 1) hematoma – in 121 cases (4.0%), 2) puncture of an artery – in 83 (2.7%), and one case of catheterization the right subclavian arteria, 3) bleeding from the catheter passage area – in 82 (2.7%), 4) clinically significant lymphorrhea – in 42 cases (1.4%).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11350568	FAM fluorescent channel. (	[ { "tags": [ "O", "O", "O", "O", "O" ], "tokens": [ "FAM", "fluorescent", "channel", ".", "(" ] } ]
PMC11792090	Representative flow cytometric profiles illustrating fluorescence expression on cells, where dual fluorescent signals indicate phagocytosis by M1 macrophages. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Representative", "flow", "cy...
PMC11653533	Moreover, aqueous extract of Ficus religiosa has possessed an anti-diabetic effect against type 2 diabetic rats induced by streptozotocin, where fasting glucose levels for 100 and 200 mg extract were 124.7 ± 3.6 and 110.4 ± 3.2 mg/dl respectively, following that, postprandial blood glucose level was found to be 155.2 ± 4.1 and 137.0 ± 3.5 mg/dl respectively (Kirana et al., 2011).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10470467	Finally, in order to further explore the function of these genes in pan-cancer, we utilized the GSCALite database (17) to perform genome-wide and pathway activity analysis.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11723947	To ensure that assays could be properly interpreted, and to avoid confounding factors such as poor cryopreservation of the PBMC, we quantified cell viability after thawing and a 20 ± 4 h recovery period and ran the same quality controls on all PBMC included in this study.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11593713	The homogeneity of variance was assessed using Levene’s test.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "homogeneity", "of", "variance", "was", "assessed", "using", "Levene", "’s", "test", ...
PMC11286266	Histograms of the signal in each channel are displayed on the axes.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Histograms", "of", "the", "signal", "in", "each", "channel", "are", "displayed",...
PMC8009078	The GBSA approach is used to get the enthalpy term.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "GBSA", "approach", "is", "used", "to", "get", "the", "enthalpy", "term", "." ] ...
PMC11438317	The cells were left untreated or stimulated with CD3/CD28 antibodies for for 6 h. The insert shows the IB of the SLP76 and LYP proteins expressed. *	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11457557	However, it depicts a diverse collection of disorders that are perpetuated by different processes and could even coexist in various combinations, especially in people with T2DM.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11592008	UVB strongly induces NLRP1 inflammasome activation in human keratinocytes .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "UVB", "strongly", "induces", "NLRP1", "inflammasome", "activation", "in", "human", "keratinocytes", "." ...
PMC10747139	A molecular docking study also supported the obtained results, thus showing that Ru complex 1 is located in the IA pocket (Trp134) with a binding affinity (−7.27 kcal/mol) that is slightly lower than the ligand (−8.05 kcal/mol), and the results were in agreement with the binding constants.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11756937	Approximately at passage 10, several cryovials for a MB were cryopreserved followed by expansion and cryopreservation of vials for DB (Figure 1).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC8494202	In addition to the above clinical and molecular characteristics of glioma patients, the status of radiotherapy and chemotherapy in our univariate analysis tends to be a risk factor, but the multivariate analysis is actually a protective factor for the prognosis of patients.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973	There was no significant difference in demographic data, clinical presentation, type of mutant gene, and overall or reactivation free survival according to liver involvement.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11519077	Moreover, since there is a growing body of evidence that transplanted MSCs' therapeutic and immune-regulatory effects are mostly dependent on the paracrine rather than cellular mechanisms , and also due to variable secretions of MSCs based on the tissue of origin , the effect of all the MSCs' corresponding conditioned media was also assessed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7759933	In our study, the expression of cyclin protein coding gene CCND1 was downregulated and a decrease in the first seven days was noticed from a −4.76-fold change after 3 days of cultivation to −8.33-fold change after 7 days of cultivation (Figure 3B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11806818	In order to improve the prognosis of cervical cancer patients and achieve effective diagnosis of early cervical cancer, Zhu et al. proposed a novel single aptamer-dependent sandwich-type biosensor for the colorimetric analysis of cancer cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11742431	Both KVN and K14N were effective in inhibiting the proliferation of 5637 and UMUC‐3 cells by clonogenic assays.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O" ], "tokens": [ "Both", "KVN", "and", "K14N...
PMC11591038	The total expenses for AD healthcare in 2023 were around USD 345 billion and are predicted to escalate to more than USD 1 trillion by 2050 due to the aging population .	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11612626	Treatment of tumor cells with allogeneic T cells also generated only ∼5% apoptotic in myeloma cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Treatment", "of", "tumor", "cells", "with", ...
PMC11478724	It controls the metabolic cross-talk between the mitochondria and the rest of the cell by mediating the flux of ions, nucleotides, Ca (2+), and other metabolites across the membrane.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11537649	The expression of NEAT1 in A375 was significantly higher than that of Hacat (Fig. 1B).	[ { "tags": [ "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O" ], "tokens": [ "The", "expression", "of", "NEAT1", ...
PMC11679892	A similar protocol was applied for all other ELISA tests.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "similar", "protocol", "was", "applied", "for", "all", "other", "ELISA", "tests", "." ...
PMC11190538	C-PC encapsulated yoghurt showed a high capacity to scavenge the DPPH and ABTS radicals due to the remains of C-PC in yoghurt.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "C-PC", "enca...
PMC5874706	Other solvents were of chemical grade and were used as received.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Other", "solvents", "were", "of", "chemical", "grade", "and", "were", "used", "as", ...
PMC9429973	T. Devos, V. Havelange, K. Theunissen, S. Meers, F. S. Benghiat, A. Gadisseur, G. Vanstraelen, H. Vellemans, B. Bailly, N. Granacher, P. Lewalle, A. De Becker, K. Van Eygen, M. Lejeune, M. Janssen, A. Triffet, I. Vrelust, D. Deeren, D. Mazure, M. Beck, H. Sebti, D. Selleslag Department of Hematology, University Hospitals Leuven; Department of Microbiology and Immunology, Laboratory of Molecular Immunology (Rega Institute), Leuven; UCL Saint-Luc, Woluwe-Saint-Lambert; Jessa Ziekenhuis, Hasselt; Algemeen Ziekenhuis Klina, Brasschaat; Hôpital Erasme, Bruxelles; Universitair Ziekenhuis Antwerpen, Edegem; CHR Verviers, Verviers; CHU UCL Namur, Site Godinne, Yvoir; Hôpital de Jolimont, Haine-Saint-Paul; Ziekenhuis Netwerk Antwerpen Stuivenberg, Antwerpen; Institut Jules Bordet, Université Libre de Bruxelles, Bruxelles; Universitair Ziekenhuis Brussel, Jette; Algemeen Ziekenhuis Groeninge, Kortrijk; Centre Hospitalier Universitaire de Liège (Sart-Tilman), Liège; Ziekenhuis Oost-Limburg, Genk; Centre Hospitalier Universitaire Charleroi Vésale, Charleroi; Algemeen Ziekenhuis Sint-Elisabeth, Turnhout; Algemeen Ziekenhuis Delta, Roeselare; Universitair Ziekenhuis Gent, Gent, Belgium; Incyte Biosciences Benelux B.V., Amsterdam, Netherlands; Algemeen Ziekenhuis Sint-Jan Brugge, Brugge, Belgium Background: Ponatinib is a third-generation tyrosine kinase inhibitor (TKI) indicated for adult patients with chronic, accelerated or blast phase CML resistant or intolerant to nilotinib or dasatinib or with Ph+ALL resistant or intolerant to dasatinib or for patients with the T315I mutation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11144200	Figure 1 shows how MAL-PEG2000-DSPE linked Nb36 to the surface of liposomes, which enhances its antigen-binding ability due to the high concentration while preventing the CTLA-4/B7 signaling process for T cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10891340	Viral DNA was extracted by Magen HiPure Viral DNA Kit (Magen, Guangzhou, China).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Viral", "DNA", "was", "extracted", "by", "M...
PMC9429973	There have been no treatment-related deaths.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "There", "have", "been", "no", "treatment-related", "deaths", "." ] } ]
PMC10024132	These data provided a strong rationale for developing blinatumomab-secreting γ9δ2 T cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "data", "provided", "a", "strong", "rationale", "for", "developing", "bl...
PMC8270637	After gentle mixing, the samples were incubated in the dark for 30 min at 4°C and analyzed using flow cytometry.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After",...
PMC11389534	It has been demonstrated that UFBP1 distinctly promotes the development and function of plasma cells by modulating different branches of the UPR pathways.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "It", ...
PMC11746948	Overall, our findings uncover the intricate network regulating GPX4 palmitoylation, highlighting its pivotal role in modulating ferroptosis sensitivity.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Overall", ",", "our", ...
PMC7841189	Cell proliferation was assessed with a cell counting kit-8 (CCK-8) assay (Dojindo, Kumamoto, Japan).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cell", "proliferation", "was...
PMC11574271	These findings suggest that aberrant RON expression and activation are the pathogenic factors contributing significantly to bladder cancer malignancy.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "These", "findings", "suggest", "t...
PMC10142392	Although this reduces the thermal character of the PCL, it was observed that molecular weights are controlled with low polydispersity (weight-average molecular weight/number-average molecular weight ratio of 1.23) thanks to the ROP-ATRP sequence.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11684297	24 h after treatment, morphological observations were done under an inverted microscope followed by an MTT assay.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "24", "h", "after", "treatment", ",", ...
PMC11794588	Solanum villosum leaves and fruits are eaten or made into decoctions to cure stomach problems like dysentery and diarrhea.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Solanum", "villosum", "leaves", "...
PMC11799978	As expected, CAFs significantly promoted the 4T1 tumor cell proliferation after coculture for 48 h as compared to 4T1 culture alone (Figure 3B).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "...
PMC11463018	Antiproliferative screening against 59 cell lines of 19 (GI50, μM).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Antiproliferative", "screening", "against", "59", "cell", "lines", "of", "1...
PMC11522251	p < 0.05, p < 0.01, * p < 0.001, **** p < 0.0001, siHOXB8-1 or siHOXB8-2 relative to si-NCFig.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC10380508	However, RCC poses significant challenges in terms of treatment efficacy, as tumor metastasis and recurrence are frequently observed.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "RCC", ...
PMC9516447	GRP78 is traditionally regarded as a luminal endoplasmic reticulum (ER) chaperone with major functions in protein folding and maintenance of ER homeostasis as a key regulator of the unfolded protein response (UPR).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11748335	One exception was noted in Normal vs TN-Basal, where HCC1937 displayed an overall higher DNA methylation signal; however, even in this case, we observed that the difference between HCC1937 and MCF10A in tumor-gain LOCKs was smaller than in tumor-loss LOCKs (Fig. S3D).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11638288	Overall, the study indicates that in the absence of NKp46/NCR1, tumors formed in vivo exhibit higher levels of NKp46/NCR1 ligands, and a direct correlation was observed between the expression of NKp46/NCR1 ligands, the secretion of IFN-γ, and the in vivo growth of tumors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11367146	Volcano plot distribution for GEO datasets (D) GSE55457 (E) GSE12021 (F) GSE55235.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Volcano", "plot", "distribution", "for", ...
PMC9386809	Physical and spectral data of known compounds are in good agreement with those reported in the literature.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Physical", "and", "spectral", "data", "of", ...
PMC11697189	However, there are few studies on the mechanism of HSPA7 affecting the progression of malignant tumors.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "However", ",", "there", "are", "few", "stud...
PMC9684669	After incubation for the indicated times from the protocols, the luminescence signal in assays plates were detected in a ViewLux plate reader.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "After",...
PMC10178190	Therefore, we examined 2HE2′s ability to restore platinum sensitivity to OC cells, as mediated by secreted soluble factors from MS-5 or TA HS-5 cells.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "B-CellLine", "...
PMC11543935	Medical devices and technologies must undergo extensive testing and validation before being certified for public healthcare use, especially in oncology where a high research focus is on new advancements.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11539788	Thus, our findings showed that RNF19A inhibited bladder cancer progression by regulating ILK ubiquitination and inactivating the AKT/mTOR signalling pathway, indicating its potential as a therapeutic target for BCa treatment.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC7602170	In the same study, upon treatment with 1μM imatinib, residual KIT activation rates of GIST430 and GIST48 cell lines were 6- and 2.8-fold higher than the GIST882 cell line, respectively.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "...
PMC9261184	From consultation with the ship operators, venting from the masts was expected to occur rarely, if at all, during the ship operation.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tok...
PMC11740399	A and B) CCK8 analysis proved that 3025@ML significantly inhibited the cell viability of T24 cells and 5637 cells. (	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O" ], "tokens": [ "A", "...
PMC9429973	Overall LS mean changes through Day 545 showed significant improvements in EORTC QLQ-C30 fatigue, pain, and appetite loss, FACT-LymS, and EQ-VAS (Table).	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC11481779	The visualisation of those results can be seen in Fig. 3, and detailed per-chromosome statistics can be found in Supplementary Figs. 1–3.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", ...
PMC10523483	Mice were handled according to the Guidelines of the China Animal Welfare Legislation, as approved by the Committee on Ethics in the Care and Use of Laboratory Animals of College of Life Sciences, Wuhan University.	[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Therefore, patients with relapsed/refractory (R/R) disease represent a high unmet need, and new targets and treatment modalities are needed.

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PMC9985266

Each experiment was repeated 3 times independently.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Each", "experiment", "was", "repeated", "3", "times", "independently", "." ] } ]

PMC11240571

In 143B cells, exosome markers CD9, CD63, and CD81 were detected (Supplemental Figure S2B).

[ { "tags": [ "O", "B-CellLine", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "143B", "cells", ",...

PMC11411004

This indicates that I-4 can effectively inhibit the expression of HDAC and LSD1 in cells, thereby increasing the methylation and acetylation levels of histone H3.Fig.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ...

PMC11794588

There are around 300 species of the genus Cestrum (Family Solanaceae), which is extensively spread in tropical and subtropical regions of the world, including Bangladesh, India, the United States, Australia, South America, and southern China.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11767725

Moreover, IGF-1 suppresses the nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR-γ), disrupting sebocyte differentiation and lipid homeostasis, which further contributes to sebaceous gland dysfunction .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC8494202

Finally, we obtained the 2D and 3D structures and molecular formulas of these drugs from PubChem, as shown in Figure 10.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Finally...

PMC11629192

Jie Hong: Resources, Project administration, Methodology, Formal analysis, Data curation, Conceptualization.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Jie", "Hong", ":", "Resources", ",", "Proje...

PMC11638255

A two-way ANOVA with Sidak’s multiple comparisons test was used to identify differences between two models with two treatments.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "A", "two-way", "ANOVA", ...

PMC9429973

Blood tests showed bicytopenia (hemoglobin 10.8 g/dL normocytic/normochromic and leukocyte 2.1x10^9/L), an elevated C-reactive protein (14 mg/dl) and an elevated erythrocyte sedimentation rate (85 mm/h); lactate dehydrogenase (LDH), kidney function and liver function analysis were unremarkable.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC9429973

Results: At diagnosis, microbial diversity index of the patient group was lower than that of their siblings.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Results", ":", "At", "diagnosis",...

PMC9429973

Day 30 and day 60 mortality rates were 13% (2/15) and 20% (3/15), respectively.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Day", "30", "and"...

PMC10999934

Data was processed based on specific quality control standards: 1) cells were screened for at least 100 genes detected, with genes expressed in less than 3 cells being excluded; 2) cells with nuclear gene counts below 200 or above 6000 and at least 50% mitochondrial genes were eliminated.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC10198699

The same applies to HBM.

[ { "tags": [ "O", "O", "O", "O", "O", "O" ], "tokens": [ "The", "same", "applies", "to", "HBM", "." ] } ]

PMC9386809

327 mg (93% yield); white solid mp 189–191 °C; H NMR (400 MHz, DMSO-d6): δ 3.71 (s, 3H, OCH3), 5.78 (s, 1H, CH), 6.81–6.89 (m, 6H, Ar and CH=C), 7.02–7.04 (m, 2H, Ar), 7.05–7.37 (m, 6H, Ar), 10.81 (d, 1H, J = 1.76 Hz NH); C NMR (100 MHz, DMSO-d6): δ 55.4, 111.9, 113.8, 118.6, 118.9, 119.6, 121.3, 123.9, 127.1, 129.7, 137.1, 137.4, 157.7.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC11680391

The increase in the production level may also increase the incidence of production-related diseases (Gröhn et al. (1995)) , and dairy veterinarians today therefore need an economic mindset to allow them to focus on the costliest production diseases in dairy cows .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...

PMC5810978

We tested six cell lines (HIEC, HT29-Cl.16E, Caco-2, JVM-2, IPEC-J2, and Vero cells) and four HuNoV strains (one GII.2, two GII.4, and one GII.6).

[ { "tags": [ "O", "O", "O", "O", "O", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "B-CellLine", "O", "O", "B-CellLine", "O", "O", "O", "O", ...

PMC11543885

Hemagglutinin (HA) epitope should be avoided because biotin-phenoxyl radicals are highly reactive towards the tyrosine present in the HA sequence.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Hemagglutinin", ...

PMC11049548

In line with this, the decrement of UDP-NAcGlc and NAcGal are considered markers for cancer aggressiveness .

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "In", "line", "with", "this", ",", "the", ...

PMC9429973

Cohorts composed by fulfilling inclusion and exclusion criteria in clinical trials were excluded.

[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O" ], "tokens": [ "Cohorts", "composed", "by", "fulfilling", "inclusion", "and", "exclusion", ...

PMC11629192

The worst mRS was 5 and worst CASE was 24.

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PMC11666785

Although the number of molecules for reconstructed image with χ > 0.9 is less than χ > 0.7 and χ > 0.8, key features are well preserved.

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PMC4659567

Calcd.

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PMC11569208

FC Fold-change.

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PMC10877303

Different binding modes for the selected compounds within the MERS-CoV 3CL protein's active and catalytic sites; (A) Kihadanin B, (B) Robustaflavone, (C) 3-beta-O-(trans-p-Coumaroyl)maslinic acid.

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PMC11367939

Scale bars, A 5 μm (left) or 2 μm (right).

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PMC11495567

Consequently, earlier efforts to develop anti-RAS drugs centered on the synthesis of farnesylation inhibitors as it was observed that the C-terminal farnesyl cysteine is essential for RAS membrane localization and function .

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PMC9429973

Among patients with HGBCL, 19 achieved a complete response (CR), 3 manifested resistant disease (RD) and for 3 patients response assessment was not possible due to disease related early death.

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PMC11762280

The relative protein levels of the interested proteins were compared with ACTB as quantification (n = 3).

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PMC9429973

Identifying disrupted gene pathways specific for each SLA should therefore form the basis for targeted therapies aimed at inducing AML differentiation.

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PMC10831439

For the generation of CD19-CAR-iNKT cells, the original protocol for T cells had to be adapted considering several unique properties of iNKT cells.32 The protocol, which was established for this work, consisted of upfront iNKT-cell isolation and activation using α-GalCer-loaded autologous feeder cells, IL-2 and α-GalCer (online supplemental data 1A).

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PMC8316344

Ferroptosis and iron metabolism are intimately associated.

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PMC9429973

Image: Summary/Conclusion: Our primary data of the phase I trial have proved the primary efficacy and safety of CD33 CAR NK cells for patients with R/R AML.

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PMC11489175

USP8 removes K48 and K63 linked poly-Ub chains from substrates thereby participating in refilling of the ubiquitin cell pool and has been implicated in EGFR regulation and endosomal sorting and in protection from degradation 13, 14.

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PMC11678130

CM is a heterogeneous tumor characterized by genetically divergent subpopulations, including CSCs .

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PMC10213199

Rich factor is the ratio of the differentially expressed number of genes in the pathway and the total number of genes in the pathway.

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PMC9429973

Only one patient treated with carfilzomib-based therapies achieved a clinical response.

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PMC11306019

These SMILES notations were then input into the online tool ChemGPS-NPWeb (http://chemgps.bmc.uu.se) to obtain the ChemGPS-NP scores, as described previously (Larsson et al., 2007; Rosén et al., 2009; Korinek et al., 2017).

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PMC11637276

p < 0.0001; Kruskal–Wallis test. (

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PMC11657744

Data are presented as the mean ± SD, with statistical significance determined by two-sided unpaired Student’s t tests in GraphPad Prism. (

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PMC9429973

These were: 1) hematoma – in 121 cases (4.0%), 2) puncture of an artery – in 83 (2.7%), and one case of catheterization the right subclavian arteria, 3) bleeding from the catheter passage area – in 82 (2.7%), 4) clinically significant lymphorrhea – in 42 cases (1.4%).

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PMC11350568

FAM fluorescent channel. (

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PMC11792090

Representative flow cytometric profiles illustrating fluorescence expression on cells, where dual fluorescent signals indicate phagocytosis by M1 macrophages. (

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PMC11653533

Moreover, aqueous extract of Ficus religiosa has possessed an anti-diabetic effect against type 2 diabetic rats induced by streptozotocin, where fasting glucose levels for 100 and 200 mg extract were 124.7 ± 3.6 and 110.4 ± 3.2 mg/dl respectively, following that, postprandial blood glucose level was found to be 155.2 ± 4.1 and 137.0 ± 3.5 mg/dl respectively (Kirana et al., 2011).

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PMC10470467

Finally, in order to further explore the function of these genes in pan-cancer, we utilized the GSCALite database (17) to perform genome-wide and pathway activity analysis.

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PMC11723947

To ensure that assays could be properly interpreted, and to avoid confounding factors such as poor cryopreservation of the PBMC, we quantified cell viability after thawing and a 20 ± 4 h recovery period and ran the same quality controls on all PBMC included in this study.

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PMC11593713

The homogeneity of variance was assessed using Levene’s test.

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PMC11286266

Histograms of the signal in each channel are displayed on the axes.

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PMC8009078

The GBSA approach is used to get the enthalpy term.

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PMC11438317

The cells were left untreated or stimulated with CD3/CD28 antibodies for for 6 h. The insert shows the IB of the SLP76 and LYP proteins expressed. *

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PMC11457557

However, it depicts a diverse collection of disorders that are perpetuated by different processes and could even coexist in various combinations, especially in people with T2DM.

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PMC11592008

UVB strongly induces NLRP1 inflammasome activation in human keratinocytes .

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PMC10747139

A molecular docking study also supported the obtained results, thus showing that Ru complex 1 is located in the IA pocket (Trp134) with a binding affinity (−7.27 kcal/mol) that is slightly lower than the ligand (−8.05 kcal/mol), and the results were in agreement with the binding constants.

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PMC11756937

Approximately at passage 10, several cryovials for a MB were cryopreserved followed by expansion and cryopreservation of vials for DB (Figure 1).

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PMC8494202

In addition to the above clinical and molecular characteristics of glioma patients, the status of radiotherapy and chemotherapy in our univariate analysis tends to be a risk factor, but the multivariate analysis is actually a protective factor for the prognosis of patients.

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PMC9429973

There was no significant difference in demographic data, clinical presentation, type of mutant gene, and overall or reactivation free survival according to liver involvement.

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PMC11519077

Moreover, since there is a growing body of evidence that transplanted MSCs' therapeutic and immune-regulatory effects are mostly dependent on the paracrine rather than cellular mechanisms , and also due to variable secretions of MSCs based on the tissue of origin , the effect of all the MSCs' corresponding conditioned media was also assessed.

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PMC7759933

In our study, the expression of cyclin protein coding gene CCND1 was downregulated and a decrease in the first seven days was noticed from a −4.76-fold change after 3 days of cultivation to −8.33-fold change after 7 days of cultivation (Figure 3B).

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PMC11806818

In order to improve the prognosis of cervical cancer patients and achieve effective diagnosis of early cervical cancer, Zhu et al. proposed a novel single aptamer-dependent sandwich-type biosensor for the colorimetric analysis of cancer cells.

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PMC11742431

Both KVN and K14N were effective in inhibiting the proliferation of 5637 and UMUC‐3 cells by clonogenic assays.

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PMC11591038

The total expenses for AD healthcare in 2023 were around USD 345 billion and are predicted to escalate to more than USD 1 trillion by 2050 due to the aging population .

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PMC11612626

Treatment of tumor cells with allogeneic T cells also generated only ∼5% apoptotic in myeloma cells.

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PMC11478724

It controls the metabolic cross-talk between the mitochondria and the rest of the cell by mediating the flux of ions, nucleotides, Ca (2+), and other metabolites across the membrane.

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PMC11537649

The expression of NEAT1 in A375 was significantly higher than that of Hacat (Fig. 1B).

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PMC11679892

A similar protocol was applied for all other ELISA tests.

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PMC11190538

C-PC encapsulated yoghurt showed a high capacity to scavenge the DPPH and ABTS radicals due to the remains of C-PC in yoghurt.

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PMC5874706

Other solvents were of chemical grade and were used as received.

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PMC9429973

T. Devos, V. Havelange, K. Theunissen, S. Meers, F. S. Benghiat, A. Gadisseur, G. Vanstraelen, H. Vellemans, B. Bailly, N. Granacher, P. Lewalle, A. De Becker, K. Van Eygen, M. Lejeune, M. Janssen, A. Triffet, I. Vrelust, D. Deeren, D. Mazure, M. Beck, H. Sebti, D. Selleslag Department of Hematology, University Hospitals Leuven; Department of Microbiology and Immunology, Laboratory of Molecular Immunology (Rega Institute), Leuven; UCL Saint-Luc, Woluwe-Saint-Lambert; Jessa Ziekenhuis, Hasselt; Algemeen Ziekenhuis Klina, Brasschaat; Hôpital Erasme, Bruxelles; Universitair Ziekenhuis Antwerpen, Edegem; CHR Verviers, Verviers; CHU UCL Namur, Site Godinne, Yvoir; Hôpital de Jolimont, Haine-Saint-Paul; Ziekenhuis Netwerk Antwerpen Stuivenberg, Antwerpen; Institut Jules Bordet, Université Libre de Bruxelles, Bruxelles; Universitair Ziekenhuis Brussel, Jette; Algemeen Ziekenhuis Groeninge, Kortrijk; Centre Hospitalier Universitaire de Liège (Sart-Tilman), Liège; Ziekenhuis Oost-Limburg, Genk; Centre Hospitalier Universitaire Charleroi Vésale, Charleroi; Algemeen Ziekenhuis Sint-Elisabeth, Turnhout; Algemeen Ziekenhuis Delta, Roeselare; Universitair Ziekenhuis Gent, Gent, Belgium; Incyte Biosciences Benelux B.V., Amsterdam, Netherlands; Algemeen Ziekenhuis Sint-Jan Brugge, Brugge, Belgium Background: Ponatinib is a third-generation tyrosine kinase inhibitor (TKI) indicated for adult patients with chronic, accelerated or blast phase CML resistant or intolerant to nilotinib or dasatinib or with Ph+ALL resistant or intolerant to dasatinib or for patients with the T315I mutation.

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PMC11144200

Figure 1 shows how MAL-PEG2000-DSPE linked Nb36 to the surface of liposomes, which enhances its antigen-binding ability due to the high concentration while preventing the CTLA-4/B7 signaling process for T cells.

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PMC10891340

Viral DNA was extracted by Magen HiPure Viral DNA Kit (Magen, Guangzhou, China).

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PMC9429973

There have been no treatment-related deaths.

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PMC10024132

These data provided a strong rationale for developing blinatumomab-secreting γ9δ2 T cells.

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PMC8270637

After gentle mixing, the samples were incubated in the dark for 30 min at 4°C and analyzed using flow cytometry.

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PMC11389534

It has been demonstrated that UFBP1 distinctly promotes the development and function of plasma cells by modulating different branches of the UPR pathways.

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PMC11746948

Overall, our findings uncover the intricate network regulating GPX4 palmitoylation, highlighting its pivotal role in modulating ferroptosis sensitivity.

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PMC7841189

Cell proliferation was assessed with a cell counting kit-8 (CCK-8) assay (Dojindo, Kumamoto, Japan).

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PMC11574271

These findings suggest that aberrant RON expression and activation are the pathogenic factors contributing significantly to bladder cancer malignancy.

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PMC10142392

Although this reduces the thermal character of the PCL, it was observed that molecular weights are controlled with low polydispersity (weight-average molecular weight/number-average molecular weight ratio of 1.23) thanks to the ROP-ATRP sequence.

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PMC11684297

24 h after treatment, morphological observations were done under an inverted microscope followed by an MTT assay.

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PMC11794588

Solanum villosum leaves and fruits are eaten or made into decoctions to cure stomach problems like dysentery and diarrhea.

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PMC11799978

As expected, CAFs significantly promoted the 4T1 tumor cell proliferation after coculture for 48 h as compared to 4T1 culture alone (Figure 3B).

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PMC11463018

Antiproliferative screening against 59 cell lines of 19 (GI50, μM).

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PMC11522251

p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001, siHOXB8-1 or siHOXB8-2 relative to si-NCFig.

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PMC10380508

However, RCC poses significant challenges in terms of treatment efficacy, as tumor metastasis and recurrence are frequently observed.

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PMC9516447

GRP78 is traditionally regarded as a luminal endoplasmic reticulum (ER) chaperone with major functions in protein folding and maintenance of ER homeostasis as a key regulator of the unfolded protein response (UPR).

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PMC11748335

One exception was noted in Normal vs TN-Basal, where HCC1937 displayed an overall higher DNA methylation signal; however, even in this case, we observed that the difference between HCC1937 and MCF10A in tumor-gain LOCKs was smaller than in tumor-loss LOCKs (Fig. S3D).

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PMC11638288

Overall, the study indicates that in the absence of NKp46/NCR1, tumors formed in vivo exhibit higher levels of NKp46/NCR1 ligands, and a direct correlation was observed between the expression of NKp46/NCR1 ligands, the secretion of IFN-γ, and the in vivo growth of tumors.

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PMC11367146

Volcano plot distribution for GEO datasets (D) GSE55457 (E) GSE12021 (F) GSE55235.

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PMC9386809

Physical and spectral data of known compounds are in good agreement with those reported in the literature.

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PMC11697189

However, there are few studies on the mechanism of HSPA7 affecting the progression of malignant tumors.

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PMC9684669

After incubation for the indicated times from the protocols, the luminescence signal in assays plates were detected in a ViewLux plate reader.

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PMC10178190

Therefore, we examined 2HE2′s ability to restore platinum sensitivity to OC cells, as mediated by secreted soluble factors from MS-5 or TA HS-5 cells.

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PMC11543935

Medical devices and technologies must undergo extensive testing and validation before being certified for public healthcare use, especially in oncology where a high research focus is on new advancements.

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PMC11539788

Thus, our findings showed that RNF19A inhibited bladder cancer progression by regulating ILK ubiquitination and inactivating the AKT/mTOR signalling pathway, indicating its potential as a therapeutic target for BCa treatment.

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PMC7602170

In the same study, upon treatment with 1μM imatinib, residual KIT activation rates of GIST430 and GIST48 cell lines were 6- and 2.8-fold higher than the GIST882 cell line, respectively.

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PMC9261184

From consultation with the ship operators, venting from the masts was expected to occur rarely, if at all, during the ship operation.

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PMC11740399

A and B) CCK8 analysis proved that 3025@ML significantly inhibited the cell viability of T24 cells and 5637 cells. (

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PMC9429973

Overall LS mean changes through Day 545 showed significant improvements in EORTC QLQ-C30 fatigue, pain, and appetite loss, FACT-LymS, and EQ-VAS (Table).

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PMC11481779

The visualisation of those results can be seen in Fig. 3, and detailed per-chromosome statistics can be found in Supplementary Figs. 1–3.

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PMC10523483

Mice were handled according to the Guidelines of the China Animal Welfare Legislation, as approved by the Committee on Ethics in the Care and Use of Laboratory Animals of College of Life Sciences, Wuhan University.

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