Datasets:
OTAR3088
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BioData-CellLine_annotated

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PMC11473750
p < 0.001 and ****p < 0.0001.
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PMC9822769
The final fold activity was calculated with respect to the control wells and normalized with respect to the residual viability.
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PMC10965315
MTT powder was purchased from Sigma‐Aldrich (St. Louis, MO, USA).
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PMC11626627
However, simultaneous overexpression of TWIST1 reversed the attenuation of these abilities caused by ERβ knockdown.
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PMC11201245
Chromosomal changes in the genome of solid tumor cells lead to genomic imbalances.
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PMC11694109
As the study requires viable tumor cell suspensions, the number of cases that could be studied was quite limited but the study was nevertheless informative.
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PMC9910796
The infectious particle has a multilayered architecture that is articulated upon an endoplasmic reticulum (ER)-derived inner envelope.
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PMC9509578
In one study, phosphatidylethanolamine (PE) conjugated with PEG (PEG-PE/vitamin E)-based nanomicelles were synthesized to co-encapsulate paclitaxel and curcumin for delivery to human ovarian adenocarcinoma SK-OV-3TR paclitaxel-resistant cells.
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PMC10213199
Afterwards, A-Tailing Mix and RNA Index Adapters were added by incubating for end repair.
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PMC11190238
However, context is critical as cell-type specific EMT regulation needs to be considered.
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PMC9429973
Summary/Conclusion: The data obtained on 48 patients with MDS demonstrate a high frequency of somatic mutations (70.8%), including those detected in cases with normal karyotype (72.2%).
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PMC10606998
Each sample was diluted to a concentration of 2.2 µg/mL with Milli-Q water.
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PMC11591052
For the accurate quantification of glycolysis and respiration, the Seahorse XFe24 machine (Agilent, Santa Clara, CA, USA) and the Seahorse XF Real-Time ATP Rate Assay Kit (Agilent, Santa Clara, CA, USA) were used in accordance with the manufacturer’s instructions.
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PMC7724160
Two separate supernatant aliquots of 50 µL transferred to 96 well plates for reversed phase LC/MS analysis and HILIC LC/MS analysis respectively.
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PMC8382973
The antiviral activity of PrEP is dependent on the antiretroviral regimen.
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PMC11672881
These pathways are crucial for cell survival, proliferation, and energy production, and their disruption aligns with the gene expression changes observed.
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PMC11615828
Individual data points (velocities in anterograde and retrograde directions are shown in red and green, respectively) and the mean ± SD (black) are shown.
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PMC8343815
Spherical and rod-shaped gold nanoparticles were provided by Nanobon Company (Tehran, Iran).
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PMC11535726
Subsequently, Boonmee et al. (2012) supported the connection between the sexual morph of Kirschsteiniothelia and the asexual dendryphiopsis-like morph, based on morphological and phylogenetic analyses.
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PMC11544122
Binding was normalized to GST.
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PMC11766350
To address this problem, a transgene-specific shRNA cassette was inserted into the backbone of the rAAV genome-encoding plasmid.
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PMC11361748
Scale bars: 50 μm. (
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PMC7553912
From this point of view, the prevention of stone formation in addition to stone disintegration is important in the treatment of kidney stone disease.
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PMC11216402
The Mes-like transcriptional state was often associated with GATA4 DNA deletion and MAPK9 amplification (Fig. 8B).
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PMC6600253
Thus, PLK1 inhibition by various agents can cause postmitotic DNA damage and senescence in several cancer cell lines .
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PMC11352746
With respect to other disease areas, developing new therapeutics for CNS disorders poses distinctive difficulties due to the intricate interactions of the brain’s molecular and cellular components .
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PMC7039683
In such assays, safe harbor chromatin integration is clearly desired, although such safe harbors may be more permissive for expression in some tissues than others, and enhancer-promoter compatibility may additionally affect efficiency of in vivo reporter assays (Quillien et al., 2017).
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PMC11763764
Antibody information is listed in Supplemental Table S2.
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PMC11766309
As shown in Figure 11A, consistent with previous results, YKT6 expression levels were higher in the cervical cancer cell lines than in the normal HEK cell lines.
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PMC9927933
Here we report that UBE2C was indeed essential for growth and survival of lung cancer cells harboring Kras mutations, and UBE2C was required for Kras-induced lung tumorigenesis, since Ube2c deletion significantly inhibited tumor formation and extended the lifespan of mice.
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PMC11767793
Alternatively, assays with absorbance readouts in the gold transparency range that are based on light emission or non-optical sensing (e.g., electrochemical impedance) should be free of this issue.
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PMC8010066
The error bars indicate the standard errors of the means from a representative triplicate time. '*:
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PMC11206251
Compounds were identified by correlating the molecular ion peaks with MS fragmentation to that reported by previous researchers or online software programs, which are represented in Table 1, that displays the retention time (tR), m/z found in both modes (ESI/ESI), and a fragmentation pattern, along with the actual m/z of the identified compounds.
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PMC9100622
The objective of this project was to search for new dependencies in Ewing sarcoma, a deadly disease for which new therapeutic approaches are urgently needed.
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PMC11806182
F Leave-one-out sensitivity analysis for UCEC To investigate the cellular composition differences between UCEC groups stratified by tissue miR-330 expression, we applied the state-of-the-art deconvolution algorithm Ecotyper to the TCGA UCEC samples.
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PMC11295144
In all immunoblotting experiments, the binding of primary antibodies was visualized using alkaline phosphatase-conjugated secondary antibody and NBT/BCIP color substrate reaction.
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PMC11634794
Following a 14-day cell culture period, both 786-O and A498 cells demonstrated significantly reduced colony formation capability within the LAMP1 overexpression group as opposed to controls.
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PMC11697189
Patients were randomized into training cohorts and testing cohorts for risk signature construction and verification.
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PMC11627133
Normalized fluorescence intensity profiles of epifluorescence (dashed lines) and super‐resolved (solid line) images along the dashed line shown in E).
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PMC10968586
As regards invasiveness of ER-positive cells, experimental evidence obtained in MCF-7 and T47D cells confirmed that 50 μM HT elicited effects similar to those recorded for OLE on HGF- and 3-MA-induced cell migration .
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PMC8984067
The solution was irradiated using a 980 nm laser (power density = 1.0 W/cm) and sampled every 5 minutes.
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PMC9436459
In addition, there were only eight type A of MDAAs (50–57) with the diene moiety on A ring (C-5) of 2-arylbenzofuran (Fig. 4).Fig.
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PMC11513571
Asterisks denote p-value (*p< 0.05, **p< 0.01, ***p< 0.001).
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PMC11407042
Add 3 mL Trypsin-EDTA (0.05%) and incubate 2 min at room temperature.d.
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PMC11407042
Timing: 20 min 4.Prepare LB agar plates.5.Take the bacterial strain stored at −80°C from the freezer and place it on ice or in liquid nitrogen.6.Using a sterilized inoculation loop to streak bacterial cells onto LB agar plates containing 50 μg/mL Gentamicin Sulfate from the stored vial.7.Incubate the plates at 37°C overnight.
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PMC11267036
The Mx3000P Real-Time PCR System (Stratagene, CA, USA) was utilized in the experimental procedures, with the following conditions: 95°C, 3 min; 95°C, 12 s (40 cycles); 62°C, 40 s. Gene expression levels were determined using the 2 method, with GAPDH serving as the internal reference.
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PMC11449273
Further supporting the necessity of performing functional comparative analysis of different mutants in the same genetic background.
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PMC11593031
The two derivatives of the cell line Neuro-2a, Neuro-2a TR-alpha, and Neuro-2a TR-beta were also studied here, first described in 1994 .
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PMC11495567
Here we determine the effects of PCAIs on the viability, G-protein levels, downstream mediators, and apoptosis-related proteins on the KRAS-mutated, Black American-derived lung adenocarcinoma cell line, NCI-H23.
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PMC11686380
COS7 cells were transfected with pCAG vector (-), pCAG-Myc-GAP43 (WT), or pCAG-GAP43-E111K (E111K).
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PMC11587606
Eight-µm pore size transwell plates were purchased from Corning (catalog #3422; State of New York, USA) covered with Matrigel (BD Biosciences).
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PMC9429973
No difference between the two groups regarding the degree of anemia, platelets counts and disease complications.
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PMC11371747
l-LV completely protects against the cytotoxicity of these antifolates including RTX and PLX which are excellent transport substrates for RFC, but also for PMX, which is a transport substrate for both RFC and PCFT.
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PMC9429973
Furthermore, after HSCT patients can suffer from non-GvHD related complications, such as cataracts, leading to compound presentations.
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PMC6442998
Single plane images were displayed using Zen2010 software (Zeiss) and exported as 8 bits uncompressed TIF images.
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PMC9243326
ncRNAs were classified according to their secondary structures and sequence conservation.
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PMC8348645
It is native to China and South East Asia .
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PMC11703992
Using the “Cellchat” package, we calculated and presented major intercellular communications between various T cell clusters and other cell clusters in GCA and elderly samples (Fig. 3F, S2B).
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PMC9429973
B-ALL was 58.7% (27 patients), T-ALL - 34.8% (16 patients), biphenotypic - 4.3% (2 patients), not defined - 2.2% (1 patient), Ph-positive ALL - 17.4% (8 patients).
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PMC6835428
Notably, its siRNA-mediated down-regulation not only reduced cell migration, it also promoted cell anoikis .
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PMC9429973
Higher CD20 expression at therapy start seems to be correlated to strong MRD response solely in the CLL2-BIO trial (p=0.036, Fig. 1).
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PMC8345486
In the control experiments, solvent (DMF) was added to the cell culture instead of the compound.
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PMC9341513
Gene size and expression measurements. (
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PMC9027909
Comparison between LPS and B3STA was statistically significant only in mir-16, mir-29a, and mir-874. *
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PMC11549612
The expression patterns, prognostic implications, and immune properties of the BOLA family in KIRC are areas that have not been explored in the existing literature.
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PMC10154881
To test the infectivity on mouse immune cells, splenocytes were inoculated with rMV‐EGFP‐SLAMblind at an MOI of 10, and then EGFP expression of immune cell populations was analyzed (Figure S4).
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PMC10874773
The results showed that tashironin exhibited significant anti-inflammatory activity with IC50 values of (2.10 ± 0.40) μmol/L and (1.93 ± 0.57) μmol/L (Bai et al., 2012).
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PMC11763111
Flow cytometry was conducted once a week to identify HuCD45 CAR cells within the peripheral blood of mice (n = 5).
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PMC11412721
RT-qPCR analysis of candidate DEGs from spleens of Trp53 (p53) Eμ-Myc males and Trp53 (p53) Eμ-Myc males.
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PMC2777936
Graphs depict a representative experiment performed in triplicate.
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PMC11799978
Sustained pH regulation using a higher concentration of NaHCO3 or longer duration has more profound effects on limiting the transition of fibroblasts to CAFs.
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PMC9429973
A total of 1,781 (72%) patients received first-line (1L), 518 (29%) patients received second-line (2L) and 239 (13%) patients received third-line (3L) therapies.
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PMC5810978
We tested further serial passages using the first passage of cell supernatants (approx.
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PMC2614415
However, at higher concentrations, we found no evidence that paclitaxel and VE-465 synergized to induce apoptosis in PTX10 cells.
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PMC5925824
While one physiological role of PD-L1 is believed to involve the suppression of T-cell activation to minimize damage to normal tissues by activated T cells , more recent evidence suggests that PD-L1 might also play important roles to modulate innate immunity by sensing hypoxic and metabolic stress.
[ { "tags": [ "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", "O", ...
PMC9429973
M. Lucijanic, I. Krecak, E. Soric, D. Galusic, H. Holik, V. Perisa, M. Moric Peric, I. Zekanovic, R. Kusec Hematology Department, University hospital Dubrava, Zagreb; Internal medicine Department, General hospital Sibenik-Knin county, Sibenik; Hematology Department, University hospital center Split, Split; Internal medicine Department, General hospital Slavonski Brod, Slavonski Brod; Hematology Department, University hospital center Osijek, Osijek; Internal medicine Department, General hospital Zadar, Zadar, Croatia Background: Blood plasma experiences substantial changes in both volume and composition in patients with chronic myeloproliferative neoplasms (MPN) and represents large reservoir of cytokines and other mediators of inflammation.
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PMC4360730
The ENCODE DCC has provided a similar interface, providing the ability to search using metadata terms (https://www.encodeproject.org/help/rest-api).
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PMC11574271
C Validation of candidate genes positively correlated with RON expression in 5637-shRON, 5637-NC, J82-oeRON, and J82-NC groups was conducted using qRT-PCR.
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PMC11607764
When the tumors grew to about 100 mm in size, the tumor volume and the body weight of normal mice were detected, and the body weight and tumor formation were in the supplemental data (Figures S6-S8).
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PMC9065483
EGFR pathway inhibitors such as gefitinib negated vanadate-associated changes in the phosphorylation and localization of STAT1/2 as well as NF-κB signaling.
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PMC11127909
Thus, EFHD1 might play a protective role in Ca-induced cell death.
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PMC8382973
RL and CVL samples were collected on September 10, 2019, and daily from September 17 to 30, 2019.
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PMC11704834
The exact mechanisms underlying the apoptosis function of E-cadherin however remain to be determined but may involve alteration of signaling pathways downstream of and regulated by E-cadherin.
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PMC11411004
In particular, small molecule epigenetic modulators are key elements that can effectively influence gene expression by precisely regulating the epigenetic state of cells.
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PMC10440586
RLZ contributed to the bioinformatics analysis and interpretation and helped refine the data visualization.
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PMC11742231
By identifying unexpected sensitivities, the model can propose existing drugs as candidates for new therapeutic applications, accelerating the development of effective cancer treatments.
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PMC11723947
Experiments were performed in agreement with the guidelines of the Declaration of Helsinki.
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PMC11782780
Hou et al. reported that miR-30d inhibits aerobic glycolysis and pancreatic tumor formation by directly targeting RUNX1, which binds to SLC2A1 and HK1 promoters and manipulates their expression.
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PMC9219615
Therefore, to further validate that apoptosis is the cell death mechanism of Tpz-1, caspase-3/7 activation (NucView 488 Caspase-3/7 Substrate Assay Kit, Biotium) was measured in compound-treated HL-60 acute myeloid leukemia and CCRF-CEM T cell leukemia cells .
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PMC11740207
Their diminutive size and capacity to fuse with other cells might explain why they have historically been overlooked in research.
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PMC9429973
Out of 4 patients, two died (median OS 9 months) and two patients are alive (4 and 1 year after allogenic bone marrow transplantation).
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PMC11666785
5corrSMLM reconstructed super-resolved images of mEos-Tom20 transfected NIH3T3 cells (targeted to mitochondrial network).The super-resolved images for SMLM and corrSMLM with correlation values (χ = 0.7 to 0.9) considering all (2-4) frames.
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PMC9436459
In light of the structural types of dehydroprenylphenol dienes, classic MDAAs (Fig. 1) can be further classified into dehydroprenyl-2-arylbenzofuran type (Type A), dehydroprenylstilbene type (Type B), dehydroprenylchalcone type (Type C), dehydroprenylflavone type (Type D), dehydroprenyldihydroflavone type (Type E), dehydroprenylsanggenonflavone type (Type F), dehydroprenylcoumarin type (Type G), and simple or other dehydroprenylphenol type (Type H).
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PMC10142392
Under these conditions, PEG chains extend, thus increasing the thickness of the outer PEG layer.
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PMC11291490
A total of 100 mg/spleen or 100 mg/brain was added to 1 mL DMEM with 1% penicillin and 1 μg/mL streptomycin for homogenization.
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PMC11767817
Next, 70% ethanol was added to the cells, and samples were incubated for 30 min at 4 °C.
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PMC11087055
In this study, our loss-of-function technique, introducing ΔDEP to PS cells, demonstrated that the polonaise movements were preserved along the deformed PS (Figure 1, and Video 1).
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PMC11634027
Deleting the D-II or D-III motifs did not significantly alter Ds protein levels as assayed by western blotting (Fig. 3J,K).
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PMC11791264
SETD7 is a significant modifier of multiple non-histone proteins and exerts either tumor-suppressive or oncogenic functions in various cancer types (16).
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PMC8633974
Transmission electron micrographs of single- or dual-tat mutants are illustrated, confirming viral particle formation similar to wild-type viruses.
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