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PMC6267596
Multiple cell cycle kinase inhibitors are able to induce polyploidy [7–12] as do DNA-targeted (e.g. anthracyclins, etoposide) and microtubule-targeted (e.g. vinca alkaloids, taxanes) anti B-NHL chemotherapies .
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PMC8875242
The measured [H]-digoxin concentrations were normalized against the protein content.
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PMC11656657
To ensure accurate comparison and data normalization across samples, counting beads were utilized. *
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PMC7762347
MEM, methanol ethanol, DMSO, trypsin and PMS (phenazine methosulfate) were provided from Sigma, St. Louis, MO, USA.
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PMC9429973
IRAEs are mild, low-grade.
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PMC10203589
suggesting that FGF18 may affect lung cancer progression through the FGFR1 pathway.
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PMC11706776
Dark blue: G0/G1 phase, Light blue: S phase, Purple: G2/M phase.
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PMC9622879
Figure 6 depicts the energy cost of our proposed community with three CEMSs for a day, whereas the indoor temperature during this day, which is the same at every home, is illustrated in Fig. 7.
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PMC9429973
Interestingly, cells with higher Myc-levels were especially sensitive to this flavonoid.
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PMC11764090
These strategies included changes in cellular membranes and chloroplast structure, regulating cold signals related to phytohormones and plant growth regulators (ABA, JA, GA, IAA, SA, BR, ET, CTK, and MET), reactive oxygen species (ROS), protein kinases, and inorganic ions.
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PMC9429973
Vascular accesses were successfully insered in all patients.
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PMC11610461
The cells were washed twice with calcium-free PBS, fixed with 4% paraformaldehyde for 20 min, and stained with 0.1% crystal violet for 10 min.
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PMC11469524
These three modeling steps were iteratively repeated for every network change until no further alteration was supported by the data [Final Network].
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PMC11269933
Pairwise interactions were tested using GAL4 Yeast Two-Hybrid Media Kit (Coolaber, China).
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PMC9429973
Results: Trial in progress.
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PMC10988555
The excitations reported in Table S2 are highlighted (*).
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PMC11343332
Here, the breast cancer cells were significantly reduced after treatment with pycnogenol for 24 hours, and the cells exhibited indications of cytotoxicity by shrinking and blebbing of the cytoplasmic membrane.
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PMC11721277
ESI-HRMS m/z calculated for C49H60N10O12 [C49H60N10O12+H]: 1013.4191.
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PMC11700340
Shows the Impact of Linagliptin on the Growth Suppression of the Hela Cancer Cell Line at 24- and 72-hour Intervals. ,
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PMC5363531
Cell viability assays demonstrated that pretreatment with dasatinib significantly decreased PEM IC50, being the reduction higher in mD and co-administration conditions.
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PMC9429973
Twenty-four immune-related adverse events were documented (4 gastrointestinal, 4 hepatic, 6 fever, 4 hematological, 3 dermatological, 3 allergic rhinitis).
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PMC11790971
Although many studies indicated relationship between optical biomarkers and metabolic status of cells, the interpretation of the top-ranking features and their biological significance to biopharmaceutical cell line characterization remains a subject for future research, necessitating in-depth molecular and cellular investigations.
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PMC11049548
The A2780 cell line is derived from an ovarian endometrioid adenocarcinoma of an untreated patient.
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PMC9019892
The phosphorylation of FRS2α was increased after treatment with imatinib for 4 days, a finding not found with nintedanib treatment and was consistent with the imatinib‐induced activation of the FGF signalling pathway (Fig. 5A).
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PMC6024716
The increase in luciferase activity of the knockout cell lines is accompanied by an increase in both mRNA transcription and protein expression.
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PMC10994876
Simultaneously, a separate group of cells was transfected with the PB513B-1 vector, which solely consists of the vector backbone without the transgene (blank construct).
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PMC11615218
By contrast, IL-2 drives terminal differentiation of CD8 T cells through the high-affinity IL-2 receptor .
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PMC9429973
For graft-versus-host disease (GVHD) prophylaxis 22 (20,3%) patients received anti-thymocyte globulin (ATG), 52 (48,2%) – posttransplant cyclophosphamide (PT-Cy), 12 (11,1%) – ATG + PT-Cy, 13 (12%) – T-cell depletion protocol and 9 (8,4%) patients received other immunosuppressive regimens.
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PMC9429973
As population aging and life-expectancy continues to increase worldwide, ITP in the elderly is a growing concern in everyday clinical practice.
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PMC10955424
Two FDA-approved JAK inhibitors: ruxolitinib (JAK1/2 inhibitor) and tofacitinib (JAK1/3 inhibitor) were used.
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PMC7917457
The numbers of mice in each group were 11−12.
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PMC10452486
Interestingly, in the CEM cell lines, there were low levels of HLA-B27 dimers in the cell lysates in the absence of oxidative stress, whereas the Jesthome cell line, which expresses a higher level of HLA-B27 than the CEM cell lines, displayed dimers under normal conditions.
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PMC11766174
The application of CA-ICC to evaluate the activity of small-molecule targeted activator of cell-kill (TACK) in clinical specimens is presented.
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PMC11350568
To gain insights into why the TMPDS composed of AptG-1 and TfR1 possesses a much greater endocytosis rate, we next turned our attention to carry out mechanistic studies, including the comparison of the binding ability of AptG-1, AptG-2, HG1–9, and XQ-2d with Sgc8c, as well as identifying the endocytosis pathways of AptG-1, AptG-2, and Sgc8c ∼ lib.
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PMC11676674
CellProfiler uses the concept of a ‘pipeline’ of individual modules; each module processes images in several ways, and the modules are placed in sequential order to create a pipeline.
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PMC11015054
In addition, 10% FBS was added to DMEM medium to culture the remaining cells.
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PMC11607638
The abscissa in panels (A–I) are time in min. (
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PMC11678448
This study employed transcriptome sequencing technology to examine alterations in cytokine levels in cell supernatant and lymphocyte gene expression following exposure to goat-derived P. multocida type D in PBLs and to explore the genes associated with P. multocida type D infection.
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PMC9429973
Additionally, our data highlight serum sclerostin and RANKL:OPG ratio as potential biomarkers to assess and monitor bone loss.
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PMC7171147
Transduced cells were selected by puromycin (5 µg/ml) treatment for 72 h and gene knockdown in these cells was confirmed by Western blotting.
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PMC9429973
Screening for Cryptococcus neoformans in selected individuals might reduce the risk of disseminated infection and death.
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PMC11574271
Subsequently, the cells were stimulated with the RON-specific ligand MSP for 30 min, and western blot analysis was performed to assess the phosphorylation levels of ERK and JNK.
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PMC10606998
In our work, the increase in reactive oxygen species was only 10% for A-172 and Gl-Tr cells after cultivation in the presence of nanoparticles and photon irradiation (Figure 6).
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PMC11767793
However, cationic charged NPs had a propensity to adhere to the cell and/or well plastic surface and were not fully removed after several PBS rinses.
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PMC11747949
Dot and violin plots depicting MFI of CAIX, PD‐L1, CCR2, VEGFR and CD44 surface protein staining on tumor cells from mice treated with vehicle control (pink with red circles) or CCR2 antagonist (yellow with brown circles).
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PMC11782508
Agarose gel electrophoresis for detection of the azurin gene.
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PMC11770199
Briefly, the Caspase-3/7 reagent was diluted in PBS with 5% FBS and incubated with cells at 37 °C for 30 min.
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PMC11012012
No human anti-mouse antibody responses were documented .
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PMC9429973
The duration of symptoms before presentation was 8 (2-192) weeks.
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PMC9429973
Interim analysis results are presented.
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PMC10237474
To establish the PB stable expression platform, we co-transfected PB transposase with PB expression vector(s) encoding our GOI.
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PMC11438317
Although LYP dephosphorylates LCK in vitro , LCK Y394 peptide is a weaker substrate than the SKAP2 Tyr75 peptide .
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PMC11122631
All nine compounds might be P-glycoprotein substrates (Table S16).
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PMC6835428
Because of its pro-proliferative effects, EGFR has also been considered as a drug target .
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PMC11064533
Deletion of yggT had a statistically significant (P < 0.05) increase in adhesion up to 184% that of the wild-type strain (Fig. 4A).
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PMC10362265
We have analyzed all known IL18-IL18BP complexes in the PDB by all-atom MD simulations.
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PMC11388384
We localized SHH-Halo particles in frames captured every 6 ms and calculated the maximum likelihood diffusion rate for each molecule in 18 ms intervals: SHH-Halo diffused in four discrete populations with rates of ~20 µm/s, ~1 µm/s, ~0.2 µm/s, and <0.1 µm/s (Fig. 2E).
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PMC11612626
Animals were acclimated for 2 days before experimental procedures.
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PMC11001582
Source data We next turned our attention to neuropathological analysis of the ventral horn of the lumbar spinal cord as this is where the large alpha motor neurons reside that undergo degeneration in ALS.
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PMC11352877
Despite existing knowledge of the importance of angiogenesis in the pathogenesis of uterine diseases, the precise role of angiogenic factors remains a subject of ongoing scientific research.
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PMC11683240
TcdB was detected as expected in the supernatant and after incubation with α-defensin-6 in the pellet due to aggregation.
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PMC10734950
Fold changes were determined using densitometry.
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PMC11098378
The protein was dialyzed using a 10,000 MWCO Slide-A-Lyzer G3 dialysis cassette (Thermo S4 Table) in 1 L of buffer containing 25 mM HEPES, 100 mM NaCl, 100 mM KCl, 10% glycerol, 10 mM MgCl2, 0.5 mM EDTA, 1 mM DTT.
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PMC11755519
Loss of E-cadherin expression facilitates β-catenin release, associated with reduced anchoring to the actin cytoskeleton and poor cell mechanical stability.
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PMC11026382
Considering the pattern of epistasis to TYMS Q33S, positions with negative epistasis were closest to the active site, surrounded by positions with insignificant epistasis, and finally positions in the positive epistasis cluster form an outer shell (Fig. 7a, b).
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PMC10772747
In previous studies, there has been no reported evaluation of the molecular mechanisms, gene targets, and biological process pathway mechanisms of EBE phytochemicals using a network pharmacology approach integrated with in vitro validation.
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PMC9429973
We investigated the efficacy and mechanism of OR21 in combination with VEN or TKIs for myeloid malignancies, AML, and CML.
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PMC11402217
∗p < 0.05; ∗∗ <0.01; ∗∗∗p < 0.001.
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PMC11787651
A similar trend for an increase in acetylation levels of histone H3 and H4, specifically H3K23ac, H3K14ac, H4K12acK16ac, and H2AZ K7acK11ac, was observed across both methods.
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PMC2196094
Accordingly, this organ showed expression of both MMC and CTMC proteases (Fig. 9 B).
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PMC11489351
D, representative confocal images of MCF10A cells treated as in (B).
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PMC11472569
Several potential mechanisms underlying MDR have been identified in cancer cells, including reduced drug uptake, increased drug efflux by the ABC transporter family, regulation by cancer stem cells, altered DNA damage response and repair, induction of hypoxia, altered drug targets and sequestration of anticancer drugs in intracellular organelles.
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PMC11680049
In callus and suspension cultures of Sequoia, secondary metabolites were localized in cell walls and vacuoles.
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PMC10440586
CD99 is expressed in specific cell states of gliomas.
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PMC11707577
Relative luminescence was measured using EnSpire® multimode plate reader (PerkinElmer).
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PMC10253973
Letrozole binds to Ru(II) ions through the nitrogen atom located in the triazole ring.
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PMC9429973
Median (95% CI) PFS was 9.1 (5.1-15.0) mos.
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PMC7823217
Authors declare that there is no financial/personal interest or belief that could affect the results, discussions or conclusions which are reported in this work.
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PMC11721587
We next asked how FuR phosphorylation mediates allosteric regulation of Ci.
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PMC11656380
In contrast, a human T-ALL cell line TALL-1 and normal PBMC were unaffected by Tat-Ram13.
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PMC11686380
Cells were harvested and subjected to western blotting using an anti-Myc antibody and an anti-SEPT11 antibody as a loading control.
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PMC10196713
The present study showed that Fdx1 was expressed at remarkably higher levels in the two cisplatin-resistant OC cell lines, A2789cis and OVK18cis, than in the cisplatin-sensitive parental cell lines, that is, A2780 and OVK18.
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PMC10502403
The median basal OCR/basal ECAR ratios were 0.92 and 2.33, respectively.
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PMC11707832
The transmembrane protein GManII, encoded by MAN2A1, catalyses the initial step in complex N-glycan biosynthesis.
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PMC11536589
Each group had four mice.
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PMC9386809
The aforementioned results are indicative of the efficiency of our catalyst system and provide an important supplemental method for the synthesis of important heterocyclic compounds.
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PMC11670954
.
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PMC10852540
It is of great importance to be able to explain apoptosis and cell cycle-related complex mechanisms in terms of new potential agents that have few side effects and can increase their potency together with existing drugs.
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PMC10891340
Duck-derived apoptotic transcription gene sequences were constructed.
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PMC10898159
All epigenetic changes and regulation are mediated through epigenetic enzymes (EEs), the functions of which can be divided into three categories: writers (responsible for modifications); erasers (remove modifications); and readers (identify and direct these modifications to the correct location) .
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PMC9429973
Strikingly, TLX3(F18E) in combination with FLT3-ITD led to a proliferative advantage in pro-T cells after the omission of Il7 compared to wild-type TLX3.
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PMC10938377
The phosphorus peak is almost unchanged at 33.00 ppm in the P NMR spectrum and the [M + Na] ion was observed at m/z 1448.4567 in the electrospray ionization (ESI) mass spectrum.
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PMC9368503
The resulting dataset was processed by samR using a delta score threshold of 0.77 to reach 1% FDR.
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PMC11665584
The R package MultiNicheNet can predict intercellular communication in scRNA-Seq of ligands in “sender” cells and receptors in “receiver” cells (44).
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PMC11723947
Peaks detected for each sample were merged together with BEDTools 2 v.2.29.0 and consensus peaks were quantified for each sample using featureCounts from subread v.2.0.3 with parameters -F SAF -O –fracOverlap 0.2 -p –donotsort.
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PMC11757230
Li et al. reported that MSCs inhibit metastasis in a hepatocellular carcinoma model by downregulating TGF-β expression in tumor cells.
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PMC10589262
E Western blotting analysis of KIT and BLZF1 in GIST cells with or without BLZF1 shRNA treatment.
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PMC11799620
Data were expressed as the mean ± standard deviation and analyzed by one-way ANOVA according to SPSS software (version 20).
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PMC11420784
Combined with the result that PldA accumulates cytosolic NDP52 granules and reduces the colocalization of intracellular UPEC with NDP52, these results indicate that PldA stalls preautophagosomal formation.
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PMC11365427
When ROS was eliminated, phenylalanine deprivation could not cause ROS production (Fig. 7F, Supporting Information Fig. S9A and S9B), ERS and activation of the apoptosis pathway (Fig. 7G).
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