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OTAR3088
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BioData-CellLine_annotated

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PMC9813422
Our knowledge of the tethering sites of viral episomes is limited to the mean score for the cell population.
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PMC11738017
∗∗∗∗P ≤ .0001. (
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PMC10523483
H1.2 deficiency decreased the enrichment of NRF2 in nucleus and in ARE regions within GCLC promoter and down-regulated GCLC transcription and GSH levels; while NRF2 transcriptionally up-regulated H1.2.
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PMC3681794
Inhibition of PI3K, COX-2, NFκB, STAT-3 and AP-1 can reverse resistance to cytotoxic drugs in hypoxia, implying a role for these pathways in hypoxia-induced drug resistance. , , –
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PMC11507371
The broad separation of the clusters of all plasma treatment groups reflects the adaptive potential of these cells.
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PMC8873393
Color key represents relative expression on a log 2 scale.
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PMC11449273
This increases nuclear NPM that promotes its tumor suppressive activity.
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PMC11705901
Firefly and Renilla luciferase signals were measured by the Dual-Luciferase Reporter Assay System according to manufacturer’s instruction (Promega).
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PMC11723947
Their importance in immune system homeostasis is best exemplified by the severe systemic autoimmunity and lymphoproliferative disorders observed in Treg-deficient Scurfy mice and in human IPEX patients carrying non-functional or hypomorphic alleles of the Foxp3 gene.
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PMC9429973
The median follow-up is 11 months (range, 1-46+).
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PMC8343815
Moreover, it was found that AuNRs could enhance the radiosensitivity of HeLa cells more than spherical-shaped AuNPs.
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PMC10506676
Total RNA that had been subjected to DNase was used as the negative control.
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PMC11391695
More importantly, pcDNA/PEI/NPs@M demonstrated favorable therapeutic effects in both subcutaneous graft tumor models and orthotopic mouse models by effectively inhibiting tumor growth in nude mice, resulting in a significant reduction in both tumor weight and quantity.
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PMC11011837
Specific pathway shows enhanced activity in one cell line more than the others.
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PMC11496728
Comparison of gene copy number of stably expressed SEAP in CHO-WT and CHO-KO cells.
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PMC11092418
After removal of any condensation on the lid, the plate was returned to the IncuCyte Zoom instrument with a 10 × objective using the IncuCyte™ chemotaxis system.
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PMC11544771
The percentages of cells undergoing apoptosis were analyzed using FACS Diva software (Version 8.0) (BD Bioscience, San Jose, CA, USA).
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PMC11591052
A total of 20,000 cells were seeded in each well of a 96-well plate, and the cells were exposed to varying doses of 20E for 24 h. The Glucose Uptake Assay Kit (Abcam, ab136955, Waltham, Boston, MA, USA) was used in accordance with the manufacturer’s instructions on the day of analysis.
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PMC11755519
Both normoxic and hypoxic exosomes increased the viability, motility, and migratory ability of low-grade cells.
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PMC9429973
Accordingly, cell cycle, homologous recombination, DNA replication, and Fanconi anemia pathways, were significantly deregulated in T-ALL with del(17q), and a significant association with deletions of RB1 (37%)(p<0.001) and TP53 (20%)(p=0.017) emerged.
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PMC11695623
Pentobarbital sodium and cervical dislocation euthanasia were performed to decrease animal suffering in the course of the experiment.
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PMC11185260
It was recently reported that small-molecule inhibitors targeting AURKA could enhance the radiation sensitivity of ATRT cells36 and cisplatin-induced cell death in esophageal adenocarcinoma cells,58 suggesting that attenuation of AURKA expression by exogenous SMARCB1 restored by scL-SMARCB1 treatment could improve the efficacy of either radiotherapy or chemotherapy against SMARCB1-deficient ATRT.
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PMC7039683
All trimmed, paired reads were aligned to human genome assembly 19 (hg19) using Bowtie 2 (Johns Hopkins University, Baltimore, MD, default parameters; Langmead and Salzberg, 2012).
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PMC11782780
Four members make up the highly conserved family of DNA-binding transcription factors known as early B-cell factors (EBFs).
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PMC11011837
These results, at the level of polar metabolites, highlight potential biomarkers and distinct behaviors for some cell line.
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PMC9429973
Data from the 3-assay comparison suggested that we established a successful assay calibration methodology with IVT-RNA in PBS lysate background as control material and the NPM1/ABL % value reported by the NPM1 Mutation Prototype Assay was compatible with other comparator assays.
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PMC10994876
Specific productivity was determined by calculating the EPO concentration in the supernatant and normalizing it to control cells.
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PMC10335954
Apoptosis assessment was performed using an Annexin-V/FITC Apoptosis Detection kit (Invitrogen; Thermo Fisher Scientific, Inc.) according to the manufacturer’s protocols.
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PMC10761571
At first, lung adenocarcinoma cells (5✕10) were treated with the NPs (at IC50) for 24 h and then, their RNA content was extracted (TriZol, Sigma-Aldrich, USA).
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PMC11036064
Besides exerting anti-tumoral effects on the cell viability, migration, cell cycle, apoptosis, and clonogenicity of A172 cells, its combination with temozolomide enhanced temozolomide anti-tumoral effect.
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PMC11680982
After fixation with 4% paraformaldehyde for 20 min, the plates were stained with crystal violet (Beyotime, Jiangsu, China) for 15 min.
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PMC11258145
Thus, the level of extracellular LDH was measured as an indicator of cytotoxicity. (
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PMC11047729
In the regulatory region of target genes, the RAR/RXR heterodimer binds to retinoic acid response elements (RAREs), which results in a conformational change by triggering the release of corepressors and the engagement of co-activator complexes .
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PMC10154881
Thus, the models of immunocompetent mice with these mouse cancer cells enabled us to investigate the immune responses induced by rMV‐SLAMblind therapy.
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PMC3164356
The epidermal growth factor receptor (EGFR) also plays a role in the entry of HSV-1 into CHO-K1 cells.
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PMC9351137
DAPI staining is shown in blue, α-tubulin in green.
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PMC11687663
An estimated 50% of medications were obtained through the use of herbal products.
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PMC10993311
As pregnancy progresses, the placenta grows and uteroplacental blood flow increases, requiring a larger number of vessels (Kazma et al., 2020).
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PMC11357960
Together, these results indicated that dysregulated gene expression of SUMO machinery components may be a potential underlying cause of developing resistance to anti-PD-1 immunotherapy, and effective circulating biomarkers for predicting the efficacy of this treatment.
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PMC11762280
I Proteins of GSDMD-FL, N-GSDMD, cleaved PARP, cleaved caspase-3, and p-MLKL in the epidermis of DSF or vehicle treated mice were detected by western blotting assay.
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PMC11721277
Based on the biodistribution data, tumor-to-organ ratios were calculated and are presented in Figure 3 and Table S2.
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PMC7338939
In the third group, cells were treated for 6 days, representing a long-term treatment.
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PMC11721096
The ositive cells of CHO-S-hTYR express human tyrosinase in the form of membrane proteins on the CHO-S cell.
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PMC11476222
GD1a, GD1b, GD2, GM1, and GD3 standards were run on the LC-MS to determine ganglioside retention times.
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PMC6684588
Platinum needle electrodes (model F-E2M-48, Grass Technologies) were inserted superficially onto the TA muscle for muscle stimulation via a biphasic muscle stimulator (model 701 A, Aurora Scientific).
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PMC11128598
Colon, breast, glioblastoma and head and neck cells carrying the HR cassette were pretreated with LBH for 24 h and then transfected with an I-SceI endonuclease-expressing plasmid together with the pDsRed-N1 plasmid (red), to normalize for transfection efficiency, then incubated again for an additional 48 h. Mirin, an inhibitor of MRN complex (Mre11-Rad51-Nsb1) required for HR, was used as a control (50).
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PMC11737091
In this study, it was confirmed that after DBF4 knockdown, the growth of ccRCC cells was inhibited both in vitro and in vivo, the migration of ccRCC cells was attenuated, and the cell cycle was arrested at the G1 phase in ccRCC cells.
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PMC11661024
Programmed cell death generally occurs as a homeostatic mechanism for keeping up the cell population in the body [25–27].
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PMC10440586
Representative IHC staining images of CD99 and immune cell marker CD45.
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PMC11705862
For the Western blot, the antibodies used for IRIS-1 was Capra, custom made #614.610 or #613.610, 1:1000 in Quench, with the goat-anti-rabbit Abcam/Dako 1:5000.
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PMC11772585
We therefore explored the specific genes that undergo direct m7G modification, as well as the potential direct involvement of m7G in the regulation of glycolysis.
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PMC11267830
Therefore, we verified that THOC1 is an important downstream gene.
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PMC11612315
Blood was drawn before (0 min) and after the intraperitoneal administration of glucose (2.0 g/kg body weight) at intervals of 2, 6, 10, 30, 60, and 120 min (n = 3–4 per time point).
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PMC9429973
AMLOS, the integral risk stratification system developed by integrating AELN and the clinical prognostic factors, is a widely applicable prognostic model for treatment guidance in adult patients with AML.
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PMC9429973
All the pts in the FU analysis were in complete remission.
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PMC11551844
After 24 h, wine red solutions were obtained with contignasterol and ansellone whereas no colour change was observed with motuporamine A and MN100 as they precipitated in the solutions.
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PMC9919300
Curcuma, also termed turmeric, is a member of the Zingiberaceae family and is well known for its biological activities.
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PMC11754432
4 µm sections were processed routinely.
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PMC8469018
Separation of the analytes was performed on reverse-phased Phenomenex Kinetex C18 analytical column (5 µm spherical particles, pore size 100 Å, 250 × 4.6 mm) and C18 precolumn insert.
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PMC11699465
Science and Technology Innovation Plan from Weifang Medical University (041011).
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PMC10728535
Cisplatin targets cancerous cells by forming adducts/crosslinks with DNA purine bases, preferably with guanine.
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PMC11543853
Therefore, the infected cells probably only contained a small fraction of activated particles, which indicates that they are short-lived and rapidly release their genomes to become empty capsids.
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PMC11286266
Contour plots as in ‘A’ using parental cells and a single FURIN∆ clone (#2.2.G).
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PMC5854676
Malignancy is considered to be the leading cause of long term injury, morbidity, and mortality worldwide.
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PMC10823017
Treatment with BYL719 (10 µM) resulted in a decreased number of live cells (82.4%) compared to the control group, and this resulted in an increased number of cells undergoing early (8.37%) (P<0.01) and late apoptosis (4.07%) (P<0.05).
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PMC9712534
Values of DMSO-treated samples were arbitrarily set 1, and average values of relative intensities of western blot bands were calculated (n = 3; bar, SD).
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PMC11290772
Afterward, the pellet was divided into two parts.
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PMC10976516
NCT05886075NCT05860374 Clinical applications of systemic OV therapy for lung cancer According to GLOBOCAN 2020, lung cancer has worldwide an expected 2.2 million new cases (11.4%) and is the major cause of cancer mortality, with an estimated 1.8 million deaths (18%).
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PMC9429973
DDX41 variants were significantly more common in higher risk MDS (7.1%) and secondary AML (9.7%), compared with other myeloid neoplasms (1.9%).
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PMC11748618
The variant rs73004025 is located downstream of CHD1L and was associated with altered methylation states in K562 and CD8 + T cells.
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PMC9429973
RNAseq was used to investigate the molecular mechanisms underlying the improved self-renewal of CDK4/CDK6 HSCs.
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PMC9429973
Dephosphorylation of GSK-3β results in activation of this kinase, leading to phosphorylation of MCL1, promoting degradation of this antiapoptotic protein.
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PMC11194678
Fig. S1 shows the distribution and expression level of endogenous STAU1, mTOR, and autophagy factors in different cell lines, in vitro phase separation of STAU1, and identification of mutations to disturb phase separation.
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PMC11711871
Primary rat embryonic fibroblasts from control (+ / + , wild-type), GR (− / − , knockout ) and GR (mutant) grown as described in DMEM (Gibco BRL) supplemented with 5% heat-inactivated fetal bovine serum.
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PMC9429973
Immune populations were categorized using the mean percentage value of healthy controls as cut-off.
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PMC11765879
Statistical significance was considered when the p-value was less than 0.05.
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PMC9429973
In Singapore, hypomethylating agents (HMA), particularly azacitidine, is the most used treatment in this cohort of patients.
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PMC11711063
The administration of vehicle or Bex + Carv started in randomized groups of four mice when the tumors reached 100 mm, and continued to 1000 mm in size.
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PMC10092581
A similar behavior was also observed with the Se(SIMes)‐based Au(I) complex.
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PMC10094712
According to the available data, it becomes clear that SELENOM is important for normal brain development, and its expression in various brain cancer cells is quite high.
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PMC9429973
The analysis of metabolites released by the gut bacteria was performed by the quantification of SCFAs acetate, butyrate and propionate on serum samples by MRM (LC-QQQ-MS).
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PMC11711345
The NCI-60 screening is initially performed at a single concentration of 10 µM and, when toxicity is confirmed, the compound is tested in 5 of 10-fold dilutions up to 100 µM. Considering the reported absence of the p-cymene-induced toxicity (Table 1) in HCCLs, the single dose of 100 µM was primarily selected for all compounds in the present work and, considering the low toxic potential observed, the dilutions were extended to higher doses, to establish the IC50 values (successfully for Calu-3 but not for MDA-MB-231).
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PMC11344246
Our findings demonstrate the utility of our pipeline for identifying new targets and highlight potential new therapeutic options for MOC patients.
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PMC10938336
The most prevalent technique for determining a substance’s ability to inhibit cell proliferation in cultured cells is the MTT tetrazolium assay.
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PMC11763533
Alterations in the intracellular pH (ΔpHi) within cells and their organelles can result in the disruption of cell proliferation, ion transport, cellular homeostasis, and potentially cell death .
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PMC11694625
Fig. 7a and b showed the number of MCF-7 cells and the intracellular ROS intensity in MCF-7 cells increased with the concentration increase of 3b and 3c (3.5 μM and 7 μM).
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PMC5034105
ZIKV research has so far been mainly focused on the pathogenesis of ZIKV-associated neurological complications.
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PMC11469524
This successful transfer strongly supports the view of the similarity of BCR signaling in both BL cell lines.
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PMC11194678
Protein levels of mCherry-HTT Q72 in the above U251/COS7 HD cells were analyzed by Western blot.
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PMC7504302
Functional consequences of deregulations in ZEB1, ERβ, SP1, and WT1 zinc-finger transcription factors are well studied in breast cancer, lung cancer, pancreatic cancer, and prostate cancer .
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PMC11638255
Fig. 7a,b).
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PMC11457557
Several important organ systems, such as the eyes, kidneys, and cardiovascular system, are affected by either DVC, which are typically categorized as microvascular complications, such as diabetic nephropathy (DN) and diabetic retinopathy (DR), or macrovascular complications, such as diabetic cardiovascular complications (DCC) [8–11].
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PMC10955424
Interestingly, addition of 2HE2 significantly restored platinum sensitivity as evident by increasing levels of cPARP (Fig. 5A).
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PMC9429973
It can be explained by the initial severity of patient’s condition, which required heparin therapy (30 pts - 81% had an initially high degree of lung damage - CT 3-4 st.)
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PMC11607638
SK2 triggered persistent cytosolic calcium spikes in SKR‐CHO‐K1 cells Fura‐2‐loaded CHO‐K1 (A, B) or SKR‐CHO‐K1 cells (C–I) were perifused, SK2 of 0 (A, C), 100 pM (D), 300 pM (E), 1 nM (F), 3 nM (G), 10 nM (H), 30 nM (B, I) was added as indicated. (
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PMC8494202
Cell migration into the wound was measured after incubation for 24 h, and the distance was calculated using ImageJ software (National Institutes of Health, Bethesda, MD, USA).
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PMC9429973
Presently, there is no diagnostic test available nor a single ‘gold standard’ sign or symptom for the disease.
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PMC9429973
ORR was defined as CR+ partial response (PR).
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PMC11098378
Interestingly, HopT1-2 lacks clear homology to known enzymes, but has been previously implicated in anti-bacterial immunity in plants.
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PMC10213199
HL60 and Jurkat cell lines were seeded into 6-well-plates and allowed to adhere in DMEM culture media with 10% fetal bovine serum (Invitrogen, Carlsbad, CA, USA).
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